Publications by authors named "Reinhold E Schmidt"

100Publications

Dupilumab to treat severe atopic dermatitis in autosomal dominant hyper-IgE syndrome.

Clin Immunol 2020 Jun 29;215:108452. Epub 2020 Apr 29.

Division of Rheumatology and Clinical Immunology, Hannover Medical University, Hannover, Germany.

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June 2020

Characterization of the clinical and immunologic phenotype and management of 157 individuals with 56 distinct heterozygous NFKB1 mutations.

J Allergy Clin Immunol 2020 Oct 9;146(4):901-911. Epub 2020 Apr 9.

Institute for Immunodeficiency, Center for Chronic Immunodeficiency, Medical Center University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany; CIBSS (Centre for Integrative Biological Signalling Studies), University of Freiburg, Freiburg, Germany; RESIST - Cluster of Excellence 2155 to Hanover Medical School, Satellite Center Freiburg, Freiburg, Germany; Institute of Immunology and Transplantation, Royal Free Hospital and University College London, London, United Kingdom; DZIF (German Center for Infection Research) Satellite Center Freiburg, Freiburg, Germany; Rheumatology and Clinical Immunology, Center for Chronic Immunodeficiency, Medical Center University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany. Electronic address:

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October 2020

Targeted Repair of p47-CGD in iPSCs by CRISPR/Cas9: Functional Correction without Cleavage in the Highly Homologous Pseudogenes.

Stem Cell Reports 2019 10 19;13(4):590-598. Epub 2019 Sep 19.

Institute of Experimental Hematology, Hannover Medical School, Carl-Neuberg-Strasse 1, 30625 Hannover, Germany; REBIRTH Cluster of Excellence, Hannover Medical School, 30625 Hannover, Germany; Division of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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October 2019

The German National Registry of Primary Immunodeficiencies (2012-2017).

Authors:
Sabine M El-Helou Anika-Kerstin Biegner Sebastian Bode Stephan R Ehl Maximilian Heeg Maria E Maccari Henrike Ritterbusch Carsten Speckmann Stephan Rusch Raphael Scheible Klaus Warnatz Faranaz Atschekzei Renata Beider Diana Ernst Stev Gerschmann Alexandra Jablonka Gudrun Mielke Reinhold E Schmidt Gesine Schürmann Georgios Sogkas Ulrich H Baumann Christian Klemann Dorothee Viemann Horst von Bernuth Renate Krüger Leif G Hanitsch Carmen M Scheibenbogen Kirsten Wittke Michael H Albert Anna Eichinger Fabian Hauck Christoph Klein Anita Rack-Hoch Franz M Sollinger Anne Avila Michael Borte Stephan Borte Maria Fasshauer Anja Hauenherm Nils Kellner Anna H Müller Anett Ülzen Peter Bader Shahrzad Bakhtiar Jae-Yun Lee Ursula Heß Ralf Schubert Sandra Wölke Stefan Zielen Sujal Ghosh Hans-Juergen Laws Jennifer Neubert Prasad T Oommen Manfred Hönig Ansgar Schulz Sandra Steinmann Klaus Schwarz Gregor Dückers Beate Lamers Vanessa Langemeyer Tim Niehues Sonu Shai Dagmar Graf Carmen Müglich Marc T Schmalzing Eva C Schwaneck Hans-Peter Tony Johannes Dirks Gabriele Haase Johannes G Liese Henner Morbach Dirk Foell Antje Hellige Helmut Wittkowski Katja Masjosthusmann Michael Mohr Linda Geberzahn Christian M Hedrich Christiane Müller Angela Rösen-Wolff Joachim Roesler Antje Zimmermann Uta Behrends Nikolaus Rieber Uwe Schauer Rupert Handgretinger Ursula Holzer Jörg Henes Lothar Kanz Christoph Boesecke Jürgen K Rockstroh Carolynne Schwarze-Zander Jan-Christian Wasmuth Dagmar Dilloo Brigitte Hülsmann Stefan Schönberger Stefan Schreiber Rainald Zeuner Tobias Ankermann Philipp von Bismarck Hans-Iko Huppertz Petra Kaiser-Labusch Johann Greil Donate Jakoby Andreas E Kulozik Markus Metzler Nora Naumann-Bartsch Bettina Sobik Norbert Graf Sabine Heine Robin Kobbe Kai Lehmberg Ingo Müller Friedrich Herrmann Gerd Horneff Ariane Klein Joachim Peitz Nadine Schmidt Stefan Bielack Ute Groß-Wieltsch Carl F Classen Jessica Klasen Peter Deutz Dirk Kamitz Lisa Lassay Klaus Tenbrock Norbert Wagner Benedikt Bernbeck Bastian Brummel Eusebia Lara-Villacanas Esther Münstermann Dominik T Schneider Nadine Tietsch Marco Westkemper Michael Weiß Christof Kramm Ingrid Kühnle Silke Kullmann Hermann Girschick Christof Specker Elisabeth Vinnemeier-Laubenthal Henriette Haenicke Claudia Schulz Lothar Schweigerer Thomas G Müller Martina Stiefel Bernd H Belohradsky Veronika Soetedjo Gerhard Kindle Bodo Grimbacher

Front Immunol 2019 19;10:1272. Epub 2019 Jul 19.

Institute for Immunodeficiency, Center for Chronic Immunodeficiency (CCI), Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany.

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October 2020

Take a second look: it's Kikuchi's disease! A case report and review of literature.

Clin Pract 2018 Oct 12;8(4):1095. Epub 2018 Dec 12.

Department of Immunology and Rheumatology.

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October 2018

Consider Syphilis in Case of Lymphopenia in HIV-Infected Men Who Have Sex with Men (MSM): A Single-center, Retrospective Study.

Infect Dis Ther 2018 Dec 30;7(4):485-494. Epub 2018 Oct 30.

Department for Immunology and Rheumatology, Hannover Medical University Hospital, Hannover, Germany.

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December 2018

Healthcare Utilization in a Large Cohort of Asylum Seekers Entering Western Europe in 2015.

Int J Environ Res Public Health 2018 10 1;15(10). Epub 2018 Oct 1.

German Center for Infection Research (DZIF), Partner Site Hannover-Braunschweig, 38124 Braunschweig, Germany.

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October 2018

Pregnancy Related Health Care Needs in Refugees-A Current Three Center Experience in Europe.

Int J Environ Res Public Health 2018 09 5;15(9). Epub 2018 Sep 5.

Department of Clinical Immunology and Rheumatology, Hannover Medical School, 30625 Hannover, Germany.

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September 2018

Primary immunodeficiency disorder caused by phosphoinositide 3-kinase δ deficiency.

J Allergy Clin Immunol 2018 11 21;142(5):1650-1653.e2. Epub 2018 Jul 21.

Division of Immunology and Rheumatology, Hannover Medical University, Hannover, Germany.

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November 2018

C5aR activation in the absence of C5a: A new disease mechanism of autoimmune hemolytic anemia in mice.

Eur J Immunol 2018 04 15;48(4):696-704. Epub 2018 Jan 15.

Molecular Immunology Research Unit, Division of Clinical Immunology and Rheumatology, Hannover Medical School, Hannover, Germany.

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April 2018

Autoimmunity and primary immunodeficiency: two sides of the same coin?

Nat Rev Rheumatol 2017 Dec;14(1):7-18

Klinik für Immunologie und Rheumatologie, Medizinische Hochschule Hannover (MHH), Carl-Neuberg Straße 1, D-30625 Hannover, Germany.

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December 2017

Detection and quantification of rituximab in the human urine.

J Immunol Methods 2017 12 7;451:118-121. Epub 2017 Sep 7.

Dept. of Hospital Pharmacy, Hannover Medical School, Germany; Dept. of Hypertension and Nephrology, Hannover Medical School, Germany.

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December 2017

Measles, Rubella and Varicella IgG Seroprevalence in a Large Refugee Cohort in Germany in 2015: A Cross-Sectional Study.

Infect Dis Ther 2017 Dec 5;6(4):487-496. Epub 2017 Sep 5.

German Center for Infection Research (DZIF), PARTNER Site Hannover-Braunschweig, Hannover, Germany.

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December 2017

The Pyrazole Derivative BTP2 Attenuates IgG Immune Complex-induced Inflammation.

Inflammation 2018 Feb;41(1):42-49

Division of Immunology and Rheumatology, Hannover Medical School, Hannover, Germany.

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February 2018

Seroprevalence of antibodies and antigens against hepatitis A-E viruses in refugees and asylum seekers in Germany in 2015.

Eur J Gastroenterol Hepatol 2017 Aug;29(8):939-945

aDepartment of Clinical Immunology and Rheumatology bDepartment of Gastroenterology, Hepatology and Endocrinology cDepartment of Medical Microbiology and Hospital Epidemiology, Hannover Medical School dGerman Center for Infection Research, Partner-site Hannover-Braunschweig eHepNet Study-House, German Liver Foundation, Hannover, Germany.

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August 2017

Negative Checkpoint Regulatory Molecule 2B4 (CD244) Upregulation Is Associated with Invariant Natural Killer T Cell Alterations and Human Immunodeficiency Virus Disease Progression.

Front Immunol 2017 27;8:338. Epub 2017 Mar 27.

Centre of Excellence for Research in AIDS (CERiA), University of Malaya, Kuala Lumpur, Malaysia; Department of Medicine, University of Malaya, Kuala Lumpur, Malaysia.

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March 2017

Limited role of interferon-kappa (IFNK) truncating mutations in common variable immunodeficiency.

Cytokine 2017 08 19;96:71-74. Epub 2017 Mar 19.

Department for Clinical Immunology and Rheumatology, Hannover Medical School, Germany.

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August 2017

Harnessing the immunotherapeutic potential of T-lymphocyte co-signaling molecules in transplantation.

Immunol Lett 2017 03 22;183:8-16. Epub 2017 Jan 22.

Organ Transplant Research Section, Department of Comparative Medicine, MBC03, King Faisal Specialist Hospital & Research Centre, Riyadh 11211, Saudi Arabia. Electronic address:

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March 2017

LILRA3 deletion is a genetic risk factor of HIV infection.

AIDS 2017 01;31(1):25-34

aClinic for Immunology and Rheumatology, Hannover Medical School (MHH), Hannover bDepartment of Infectious Diseases cDepartment of Infectious Diseases Epidemiology, Robert Koch-Institute, Berlin dAESKU Diagnostics, Wendelsheim eGerman Center for Infection Research (DZIF), Partner-site Hannover-Braunschweig, Hannover, Germany.

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January 2017

CD4(+) T cells in patients with chronic inflammatory rheumatic disorders show distinct levels of exhaustion.

J Allergy Clin Immunol 2016 08 2;138(2):586-589.e10. Epub 2016 Jun 2.

Institute for Experimental Infection Research, TWINCORE, Centre for Experimental and Clinical Infection Research, a joint venture between the Helmholtz Centre for Infection Research and the Hannover Medical School, Hannover, Germany. Electronic address:

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August 2016

Brief Report: HIV-1 Infection Results in Increased Frequency of Active and Inflammatory SlanDCs that Produce High Level of IL-1β.

J Acquir Immune Defic Syndr 2016 09;73(1):34-8

Department of Clinical Immunology and Rheumatology, Hannover Medical School (MHH), Hannover, Germany.

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September 2016

[Current seroprevalence, vaccination and predictive value of liver enzymes for hepatitis B among refugees in Germany].

Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 2016 May;59(5):578-83

Klinik für Immunologie und Rheumatologie, Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, 30625, Hannover, Deutschland.

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May 2016

Cell Surface Downregulation of NK Cell Ligands by Patient-Derived HIV-1 Vpu and Nef Alleles.

J Acquir Immune Defic Syndr 2016 May;72(1):1-10

*Department of Infectious Diseases, Integrative Virology, University Hospital Heidelberg, Heidelberg, Germany; †German Center for Infection Research, Heidelberg University, Heidelberg, Germany; ‡Department of Clinical Immunology and Rheumatology, Hannover Medical School, Hannover, Germany; and §German Center for Infection Research, Hannover Medical School, Hannover, Germany.

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May 2016

The TLR-2/TLR-6 agonist macrophage-activating lipopeptide-2 augments human NK cell cytotoxicity when PGE2 production by monocytes is inhibited by a COX-2 blocker.

Cancer Immunol Immunother 2015 Sep 3;64(9):1175-84. Epub 2015 Jun 3.

Department of Clinical Immunology and Rheumatology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany.

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September 2015

Natural killer cell heterogeneity: cellular dysfunction and significance in HIV-1 immuno-pathogenesis.

Cell Mol Life Sci 2015 Aug 5;72(16):3037-49. Epub 2015 May 5.

Department of Clinical Immunology and Rheumatology, Hannover Medical School, Carl-Neuberg-Str.1, 30625, Hannover, Germany,

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August 2015

Orai1 controls C5a-induced neutrophil recruitment in inflammation.

Eur J Immunol 2015 Jul 15;45(7):2143-53. Epub 2015 May 15.

Clinical Department of Immunology and Rheumatology, Hannover Medical School, Germany.

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July 2015

Immuno-pathomechanism of liver fibrosis: targeting chemokine CCL2-mediated HIV:HCV nexus.

J Transl Med 2014 Dec 10;12:341. Epub 2014 Dec 10.

Centre of Excellence for Research in AIDS, Faculty of Medicine, University of Malaya, Lambah Pantai 50603, Kuala Lumpur, Malaysia.

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December 2014

A dead-end host: is there a way out? A position piece on the ebola virus outbreak by the international union of immunology societies.

Front Immunol 2014 27;5:562. Epub 2014 Oct 27.

Division of Immunology and Rheumatology, University of Hannover , Hannover , Germany.

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November 2014

CD161+ MAIT cells are severely reduced in peripheral blood and lymph nodes of HIV-infected individuals independently of disease progression.

PLoS One 2014 4;9(11):e111323. Epub 2014 Nov 4.

Infectious Diseases Unit, Department of Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Heinrich Pette Institute - Leibniz Institute for Experimental Virology, Hamburg, Germany; German Center for Infection Research (DZIF), partner site Hamburg and Hannover, Hamburg and Hannover, Germany.

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July 2015

TNFR2 and IL-12 coactivation enables slanDCs to support NK-cell function via membrane-bound TNF-α.

Eur J Immunol 2014 Dec 29;44(12):3717-28. Epub 2014 Oct 29.

Department of Clinical Immunology and Rheumatology, Hannover Medical School, Hannover, Germany.

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December 2014

FcγRIII (CD16)-mediated ADCC by NK cells is regulated by monocytes and FcγRII (CD32).

Eur J Immunol 2014 Nov 19;44(11):3368-79. Epub 2014 Sep 19.

Klinik für Immunologie und Rheumatologie, Medizinische Hochschule Hannover, Hannover, Germany.

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November 2014

Disclosure and Experienced Social Support are not Related to Anxiety or Depression in a German HIV Patient Cohort.

Infect Chemother 2014 Jun 20;46(2):77-83. Epub 2014 Jun 20.

Department of Psychosomatic and Psychotherapy, Hanover Medical School, Hanover, Germany.

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June 2014

The adaptor ASC has extracellular and 'prionoid' activities that propagate inflammation.

Nat Immunol 2014 Aug 22;15(8):727-37. Epub 2014 Jun 22.

1] Institute of Innate Immunity, University Hospitals, University of Bonn, Bonn, Germany. [2] Department of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, Massachusetts, USA. [3] German Center for Neurodegenerative Diseases, Bonn, Germany. [4] Center of Molecular Inflammation Research, Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway.

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August 2014

Optimal gating strategy for determining CD4+ recent thymic emigrants in human immunodeficiency virus-1 infected patients.

Viral Immunol 2014 May 25;27(4):179-84. Epub 2014 Apr 25.

1 Department of Clinical Immunology and Rheumatology, Hannover Medical University , Hannover, Germany .

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May 2014

Multifaceted Impact of Host C-C Chemokine CCL2 in the Immuno-Pathogenesis of HIV-1/M. tuberculosis Co-Infection.

Front Immunol 2013 Oct 4;4:312. Epub 2013 Oct 4.

Faculty of Medicine, Centre of Excellence for Research in AIDS (CERiA), University of Malaya , Kuala Lumpur , Malaysia.

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October 2013

[Immune defect syndrome].

Z Rheumatol 2013 Sep;72(7):632-3

Klinik für Rheumatologie und Klinische Immunologie und Centrum für chronische Immundefizienz, Universitätsklinikum Freiburg, Hugstetter Str. 55, 79108, Freiburg, Deutschland.

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September 2013

Gαi2 is the essential Gαi protein in immune complex-induced lung disease.

J Immunol 2013 Jan 5;190(1):324-33. Epub 2012 Dec 5.

Molecular Immunology Research Unit, Clinical Department of Immunology and Rheumatology, Hannover Medical School, 30625 Hannover, Germany.

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January 2013

Thymidine analogues suppress autophagy and adipogenesis in cultured adipocytes.

Antimicrob Agents Chemother 2013 Jan 12;57(1):543-51. Epub 2012 Nov 12.

Department for Clinical Immunology and Rheumatology, Hannover Medical School, Hanover, Germany.

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January 2013

Unilateral hypertrophic osteoarthropathy in a patient with a vascular graft infection.

J Clin Rheumatol 2012 Sep;18(6):307-9

Clinic for Immunology and Rheumatology, Hannover Medical School, Hannover, Germany.

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September 2012

Selective expansion of pro-inflammatory chemokine CCL2-loaded CD14+CD16+ monocytes subset in HIV-infected therapy naïve individuals.

J Clin Immunol 2013 Jan 8;33(1):302-6. Epub 2012 Sep 8.

Clinic for Immunology and Rheumatology, Hannover Medical School, Carl-Neuberg Str.1, 30625, Hannover, Germany.

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January 2013

Cost-effectiveness of TNF-α inhibition in active ankylosing spondylitis: a systematic appraisal of the literature.

Expert Rev Pharmacoecon Outcomes Res 2012 Jun;12(3):307-17

Working Group Health Economics in Rheumatology, Clinic for Immunology and Rheumatology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625 Hannover, Germany.

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June 2012

Defective macrophage migration in Gαi2- but not Gαi3-deficient mice.

J Immunol 2012 Jul 15;189(2):980-7. Epub 2012 Jun 15.

Clinical Department of Immunology and Rheumatology, Hannover Medical School, Hannover, Germany.

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July 2012

CD20+ T cell numbers are decreased in untreated HIV-1 patients and recover after HAART.

Immunol Lett 2012 Aug 5;146(1-2):74-8. Epub 2012 Jun 5.

Dept. of Clinical Immunology and Rheumatology, Hannover Medical University, Hannover, Germany.

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August 2012

CCL2: a potential prognostic marker and target of anti-inflammatory strategy in HIV/AIDS pathogenesis.

Eur J Immunol 2011 Dec 10;41(12):3412-8. Epub 2011 Nov 10.

Clinic for Immunology and Rheumatology, Hannover Medical School, Hannover, Germany.

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December 2011

NKG2C deletion is a risk factor of HIV infection.

AIDS Res Hum Retroviruses 2012 Aug 3;28(8):844-51. Epub 2012 May 3.

Department of Clinical Immunology and Rheumatology, Hannover Medical University, Hannover, Germany.

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August 2012

Human CD8(+) T cells and NK cells express and secrete S100B upon stimulation.

Brain Behav Immun 2011 Aug 3;25(6):1233-41. Epub 2011 Apr 3.

Department of Psychiatry, University of Magdeburg, Magdeburg, Germany.

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August 2011

Cost of illness in rheumatoid arthritis in Germany in 1997-98 and 2002: cost drivers and cost savings.

Rheumatology (Oxford) 2011 Apr 11;50(4):756-61. Epub 2010 Dec 11.

Division of Clinical Immunology and Rheumatology, Hannover Medical School, Hannover, Germany.

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April 2011

Cytokine-activated NK cells inhibit PMN apoptosis and preserve their functional capacity.

Blood 2010 Aug 25;116(8):1308-16. Epub 2010 May 25.

Clinic for Immunology and Rheumatology, Hannover Medical School, Hannover, Germany.

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August 2010

Essential mixed cryoglobulinemia type III with leukocytoclastic vasculitis: remission by rituximab.

Clin Rheumatol 2013 Mar 7;32 Suppl 1:S19-20. Epub 2010 Mar 7.

Clinic for Immunology and Rheumatology, Medical School of Hanover, Carl-Neuberg-Str., 1 30625 Hanover, Germany.

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March 2013

Murine CXCR3+CD27bright NK cells resemble the human CD56bright NK-cell population.

Eur J Immunol 2010 May;40(5):1428-39

Clinic for Immunology and Rheumatology, Hannover Medical School, Hannover, Germany.

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May 2010

Depletion of functionally active CD20+ T cells by rituximab treatment.

Arthritis Rheum 2009 Dec;60(12):3563-71

Clinic for Immunology and Rheumatology, Hannover Medical School, Hannover, Germany.

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December 2009

Impact of stimulatory pathways on adipogenesis and HIV-therapy associated lipoatrophy.

Exp Biol Med (Maywood) 2009 Dec;234(12):1484-92

Clinic for Immunology and Rheumatology, Hannover Medical School, Carl-Neuberg-Strasse 1, 30625 Hannover, Germany.

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December 2009

HIV infection is associated with a preferential decline in less-differentiated CD56dim CD16+ NK cells.

J Virol 2010 Jan 11;84(2):1183-8. Epub 2009 Nov 11.

Klinik für Immunologie und Rheumatologie, Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, 30625 Hannover, Germany.

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January 2010

Combined effect of C-reactive protein and stavudine on adipogenesis.

Antivir Ther 2009 ;14(6):819-29

Clinic for Immunology and Rheumatology, Hannover Medical School, Hannover, Germany.

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December 2009

Mitochondrial DNA depletion and respiratory chain activity in primary human subcutaneous adipocytes treated with nucleoside analogue reverse transcriptase inhibitors.

Antimicrob Agents Chemother 2010 Jan 5;54(1):280-7. Epub 2009 Oct 5.

Clinic for Immunology and Rheumatology, Hannover Medical School, Carl-Neuberg-Strasse 1, 30625 Hannover, Germany.

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January 2010

Exogenous HIV-1 Vpr disrupts IFN-alpha response by plasmacytoid dendritic cells (pDCs) and subsequent pDC/NK interplay.

Immunol Lett 2009 Aug 25;125(2):100-4. Epub 2009 Jun 25.

Clinic for Immunology und Rheumatology, Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, Hannover, Germany.

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August 2009

Identification of candidate genes for susceptibility to reactive arthritis.

Rheumatol Int 2009 Oct 9;29(12):1519-22. Epub 2009 Jun 9.

Clinic for Immunology and Rheumatology, Hannover Medical School, 30625 Hannover, Germany.

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October 2009

Nerve growth factor and receptor expression in rheumatoid arthritis and spondyloarthritis.

Arthritis Res Ther 2009 2;11(3):R82. Epub 2009 Jun 2.

Clinic for Immunology and Rheumatology, Hannover Medical School (MHH), Carl-Neuberg-Strasse 1, Hannover 30625, Germany.

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March 2010