Reinhard Wetzker

Reinhard Wetzker

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Reinhard Wetzker

Reinhard Wetzker

Publications by authors named "Reinhard Wetzker"

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Role of adipose tissue in facial aging.

Clin Interv Aging 2017 6;12:2069-2076. Epub 2017 Dec 6.

Wellcomet GmbH, Karlsruhe, Germany.

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http://dx.doi.org/10.2147/CIA.S151599DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5723114PMC
June 2018

Remembering Pathogen Dose: Long-Term Adaptation in Innate Immunity.

Trends Immunol 2018 06 30;39(6):438-445. Epub 2018 Apr 30.

Department of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Jena, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.it.2018.04.001DOI Listing
June 2018

Deterioration of Organ Function As a Hallmark in Sepsis: The Cellular Perspective.

Front Immunol 2018 26;9:1460. Epub 2018 Jun 26.

Department of Anesthesiology and Intensive Care Medicine, Jena University Hospital, Jena, Germany.

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http://dx.doi.org/10.3389/fimmu.2018.01460DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6028602PMC
June 2018

The protein-tyrosine phosphatase DEP-1 promotes migration and phagocytic activity of microglial cells in part through negative regulation of fyn tyrosine kinase.

Glia 2017 02 17;65(2):416-428. Epub 2016 Nov 17.

Institute of Molecular Cell Biology, Center for Molecular Biomedicine (CMB), Jena University Hospital, Hans-Knöll-Straße 2, Jena, Germany.

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http://dx.doi.org/10.1002/glia.23100DOI Listing
February 2017

Phosphoinositide 3-kinase γ ties chemoattractant- and adrenergic control of microglial motility.

Mol Cell Neurosci 2017 01 5;78:1-8. Epub 2016 Nov 5.

Institute of Molecular Cell Biology, Center for Molecular Biomedicine (CMB), University Hospital of Jena, Hans -Knöll -Straße 2, 07745 Jena, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.mcn.2016.11.002DOI Listing
January 2017

Phagocytosis of bone marrow derived macrophages is controlled by phosphoinositide 3-kinase γ.

Immunol Lett 2016 12 5;180:9-16. Epub 2016 Oct 5.

Institute of Molecular Cell Biology, Center for Molecular Biomedicine (CMB), Jena University Hospital, Hans-Knöll-Straße 2, Jena, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.imlet.2016.09.014DOI Listing
December 2016

Phosphoinositide 3-Kinase γ Restrains Neurotoxic Effects of Microglia After Focal Brain Ischemia.

Mol Neurobiol 2016 10 9;53(8):5468-79. Epub 2015 Oct 9.

Institute of Molecular Cell Biology, Center for Molecular Biomedicine, Jena University Hospital, Friedrich Schiller University, Hans-Knöll-Strasse 2, D-07745, Jena, Germany.

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http://dx.doi.org/10.1007/s12035-015-9472-zDOI Listing
October 2016

Phosphoinositide 3-kinase gamma controls inflammation-induced myocardial depression via sequential cAMP and iNOS signalling.

Cardiovasc Res 2015 Nov 2;108(2):243-53. Epub 2015 Sep 2.

Institute of Molecular Cell Biology, Jena University Hospital, Friedrich Schiller University, Hans-Knöll-Straße 2, D-07745 Jena, Germany Integrated Research and Treatment Center, Center for Sepsis Control and Care, Jena University Hospital, Jena, Germany

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http://dx.doi.org/10.1093/cvr/cvv217DOI Listing
November 2015

Different inhibition of Gβγ-stimulated class IB phosphoinositide 3-kinase (PI3K) variants by a monoclonal antibody. Specific function of p101 as a Gβγ-dependent regulator of PI3Kγ enzymatic activity.

Biochem J 2015 Jul;469(1):59-69

Department of Pharmacology and Experimental Therapy, Institute of Experimental and Clinical Pharmacology and Toxicology, Eberhard Karls University Hospitals and Clinics, and Interfaculty Centre of Pharmacogenomics and Pharmaceutical Research, University of Tübingen, 72074 Tübingen, Germany

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http://biochemj.org/lookup/doi/10.1042/BJ20150099
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http://dx.doi.org/10.1042/BJ20150099DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4655608PMC
July 2015

Phosphoinositide 3-kinase γ affects LPS-induced disturbance of blood-brain barrier via lipid kinase-independent control of cAMP in microglial cells.

Neuromolecular Med 2014 Dec 18;16(4):704-13. Epub 2014 Jul 18.

Institute of Molecular Cell Biology, Jena University Hospital, Friedrich Schiller University, 07745, Jena, Germany.

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http://dx.doi.org/10.1007/s12017-014-8320-zDOI Listing
December 2014

PI3K-dependent multiple myeloma cell survival is mediated by the PIK3CA isoform.

Br J Haematol 2014 Aug 26;166(4):529-39. Epub 2014 Apr 26.

Division of Haematology and Oncology, Department of Internal Medicine II, University Hospital of Würzburg, Würzburg, Germany.

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http://dx.doi.org/10.1111/bjh.12920DOI Listing
August 2014

PI3Kγ integrates cAMP and Akt signalling of the μ-opioid receptor.

Br J Pharmacol 2014 Jul;171(13):3328-37

Institute of Molecular Cell Biology, Center for Molecular Biomedicine, Jena University Hospital, Jena, Germany.

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http://dx.doi.org/10.1111/bph.12698DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4080984PMC
July 2014

Hormetic signaling patterns.

Dose Response 2012 14;10(1):83-90. Epub 2011 Oct 14.

Institute of Molecular Cell Biology, CMB-Center for Molecular Biomedicine, Jena University Hospital, Germany.

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http://journals.sagepub.com/doi/10.2203/dose-response.11-012
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http://dx.doi.org/10.2203/dose-response.11-012.WetzkerDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3299530PMC
October 2012

The p101 subunit of PI3Kγ restores activation by Gβ mutants deficient in stimulating p110γ.

Biochem J 2012 Feb;441(3):851-8

Department of Pharmacology and Experimental Therapy, Institute of Experimental and Clinical Pharmacology and Toxicology, Eberhard Karls University Hospitals and Clinics, and Interfaculty Centre of Pharmacogenomics and Pharmaceutical Research, University of Tübingen, 72074 Tübingen, Germany.

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http://dx.doi.org/10.1042/BJ20111664DOI Listing
February 2012

VEGF-mediated PI3K class IA and PKC signaling in cardiomyogenesis and vasculogenesis of mouse embryonic stem cells.

J Cell Sci 2011 Jun 3;124(Pt 11):1819-30. Epub 2011 May 3.

Department of Internal Medicine I, Cardiology Division, Friedrich Schiller University, 07743 Jena, Germany.

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http://jcs.biologists.org/cgi/doi/10.1242/jcs.077594
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http://dx.doi.org/10.1242/jcs.077594DOI Listing
June 2011

PI3Kγ mediates kaposi's sarcoma-associated herpesvirus vGPCR-induced sarcomagenesis.

Cancer Cell 2011 Jun;19(6):805-13

Oral and Pharyngeal Cancer Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1016/j.ccr.2011.05.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3170773PMC
June 2011

PI3Kγ deficiency delays the onset of experimental autoimmune encephalomyelitis and ameliorates its clinical outcome.

Eur J Immunol 2011 Mar 1;41(3):833-44. Epub 2011 Feb 1.

Institute for Immunology, University Hospital Jena, Friedrich-Schiller-University Jena, Jena, Germany.

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http://doi.wiley.com/10.1002/eji.201040504
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http://dx.doi.org/10.1002/eji.201040504DOI Listing
March 2011

Targeting PI3K in neuroblastoma.

J Cancer Res Clin Oncol 2010 Dec 12;136(12):1881-90. Epub 2010 Mar 12.

Department of Molecular Cell Biology, Center for Molecular Biomedicine, Jena University Hospital, Hans-Knöll-Strasse 2, Jena 07745, Germany.

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http://link.springer.com/10.1007/s00432-010-0847-2
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http://dx.doi.org/10.1007/s00432-010-0847-2DOI Listing
December 2010

PI3Kgamma controls oxidative bursts in neutrophils via interactions with PKCalpha and p47phox.

Biochem J 2009 May;419(3):603-10

Department of Dermatology, Friedrich Schiller University, Jena, Germany.

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http://dx.doi.org/10.1042/BJ20081268DOI Listing
May 2009

Reassessment of the role of FKBP38 in the Rheb/mTORC1 pathway.

FEBS Lett 2009 Mar 15;583(6):965-70. Epub 2009 Feb 15.

Department of Structural Biology, Max Planck Institute for Molecular Physiology, Dortmund, Germany.

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http://dx.doi.org/10.1016/j.febslet.2009.02.015DOI Listing
March 2009

Overlapping and distinct roles for PI3Kbeta and gamma isoforms in S1P-induced migration of human and mouse endothelial cells.

Cardiovasc Res 2008 Oct 16;80(1):96-105. Epub 2008 Jun 16.

Center for Molecular Biomedicine, Institute of Molecular Cell Biology, Friedrich Schiller University, Jena, Am Leutragraben 3, 07743 Jena, Germany.

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http://dx.doi.org/10.1093/cvr/cvn159DOI Listing
October 2008

Additive effects of PI3-kinase and MAPK activities on NB4 cell granulocyte differentiation: potential role of phosphatidylinositol 3-kinase gamma.

J Cancer Res Clin Oncol 2008 Aug 21;134(8):861-72. Epub 2008 Feb 21.

Department of Internal Medicine II, Medical Faculty at Friedrich Schiller University, Erlanger Allee 101, 07740, Jena, Germany.

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http://dx.doi.org/10.1007/s00432-008-0356-8DOI Listing
August 2008

Continuous signaling via PI3K isoforms beta and gamma is required for platelet ADP receptor function in dynamic thrombus stabilization.

Blood 2006 Nov 13;108(9):3045-52. Epub 2006 Jul 13.

Department of Biochemistry and Human Biology, Cardiovascular Research Institute Maastricht (CARIM), University of Maastricht, PO Box 616, 6200 MD Maastricht, the Netherlands.

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http://dx.doi.org/10.1182/blood-2006-03-006338DOI Listing
November 2006

Ras activation in response to phorbol ester proceeds independently of the EGFR via an unconventional nucleotide-exchange factor system in COS-7 cells.

Biochem J 2006 Sep;398(2):243-56

Institute of Molecular Cell Biology, Medical Faculty, Friedrich-Schiller-University Jena, Drackendorfer Str. 1, 07747 Jena, Germany.

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http://dx.doi.org/10.1042/BJ20060160DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1550314PMC
September 2006

Phosphoinositide 3-kinase gamma mediates Jun kinase activation via its lipid-kinase activity.

Adv Enzyme Regul 2004 ;44:299-308

Institute for Molecular Cell Biology, University of Jena, Drackendorfer Strasse 1, D-07747 Jena, Germany.

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http://dx.doi.org/10.1016/j.advenzreg.2003.11.015DOI Listing
March 2005

Regulation of vascular L-type Ca2+ channels by phosphatidylinositol 3,4,5-trisphosphate.

Circ Res 2004 Aug 8;95(3):300-7. Epub 2004 Jul 8.

Laboratoire de Signalisation et Interactions Cellulaires, Université de Bordeaux II, Bordeaux, France.

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http://dx.doi.org/10.1161/01.RES.0000138017.76125.8bDOI Listing
August 2004

Phosphoinositide 3-kinases as targets for therapeutic intervention.

Curr Pharm Des 2004 ;10(16):1915-22

Molecular Cell Biology, Friedrich-Schiller-University Jena, Drackendorfer Str.1, D-07747 Jena, Germany.

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July 2004

Quantification of absolute Ras-GDP/GTP levels by HPLC separation of Ras-bound [(32)P]-labelled nucleotides.

J Biochem Biophys Methods 2004 Feb;58(2):111-7

Research Unit Molecular Cell Biology, Medical Faculty, Friedrich-Schiller-University, Drackendorfer Str. 1, 07747 Jena, Germany.

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http://linkinghub.elsevier.com/retrieve/pii/S0165022X0300200
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http://dx.doi.org/10.1016/j.jbbm.2003.07.001DOI Listing
February 2004

Ras activation in response to lysophosphatidic acid requires a permissive input from the epidermal growth factor receptor.

Biochem J 2003 Dec;376(Pt 3):571-6

Institute of Molecular Cell Biology, Medical Faculty, Friedrich-Schiller-University, Drackendorfer Strasse 1, 07747 Jena, Germany.

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http://dx.doi.org/10.1042/BJ20031410DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1223827PMC
December 2003

Sequence-specific binding of prePhoD to soluble TatAd indicates protein-mediated targeting of the Tat export in Bacillus subtilis.

J Biol Chem 2003 Oct 16;278(40):38428-36. Epub 2003 Jul 16.

Institut für Molekularbiologie, Friedrich-Schiller-Universität Jena, Hans-Knöll-Strasse 2, Jena D-07745, Germany.

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http://dx.doi.org/10.1074/jbc.M306516200DOI Listing
October 2003

Transactivation joins multiple tracks to the ERK/MAPK cascade.

Nat Rev Mol Cell Biol 2003 08;4(8):651-7

Institute for Molecular Cell Biology, Jena University Hospital, Drackendorfer Strasse 1, D-07747 JENA, Germany.

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http://dx.doi.org/10.1038/nrm1173DOI Listing
August 2003

Serine 338 phosphorylation is dispensable for activation of c-Raf1.

J Biol Chem 2003 May 7;278(20):17819-26. Epub 2003 Mar 7.

Institute for Molecular Cell Biology, University of Jena, 07747 Jena, Germany.

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http://dx.doi.org/10.1074/jbc.M209951200DOI Listing
May 2003

German Cancer Society--12th International AEK Cancer Congress. 25-28 March 2003, Würzburg, Germany.

Authors:
Reinhard Wetzker

IDrugs 2003 May;6(5):446-8

University of Jena, Research Unit, Molecular Cell Biology, Jena, Germany.

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May 2003

Co-operation of phosphatidylinositol transfer protein with phosphoinositide 3-kinase gamma in vitro.

Adv Enzyme Regul 2002 ;42:53-61

Research Unit Molecular Cell Biology, University of Jena, Germany.

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December 2002