Reinhard Hohlfeld

Reinhard Hohlfeld

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Reinhard Hohlfeld

Reinhard Hohlfeld

Publications by authors named "Reinhard Hohlfeld"

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An expanded parenchymal CD8+ T cell clone in GABA receptor encephalitis.

Ann Clin Transl Neurol 2020 Jan 14. Epub 2020 Jan 14.

Institute of Clinical Neuroimmunology, Biomedical Center and Hospital of the Ludwig-Maximilians Universität München, Munich, Germany.

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http://dx.doi.org/10.1002/acn3.50974DOI Listing
January 2020

Identification of circulating MOG-specific B cells in patients with MOG antibodies.

Neurol Neuroimmunol Neuroinflamm 2019 Nov 14;6(6):625. Epub 2019 Oct 14.

From the Institute of Clinical Neuroimmunology (S.W., M. Schlüter, M. Spadaro, F.S.T., A.V., R.G., C.M., S.M., R.H., T.K., E.M.), Biomedical Center and University Hospitals, Ludwig Maximilian University Munich, Germany; Research Center for Translational Medicine (A.V.), Koç University School of Medicine, Istanbul, Turkey; Department of Neurology, (A.K., B.I., R.K.), Hacettepe University Faculty of Medicine, Ankara, Turkey; Department of Basic Oncology (F.G.Ö., G.E.), Hacettepe University Cancer Institute, Ankara Turkey; and Munich Cluster for Systems Neurology (SyNergy) (R.H.), Germany.

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http://dx.doi.org/10.1212/NXI.0000000000000625DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6857907PMC
November 2019

Immune checkpoint blockade for treating progressive multifocal leukoencephalopathy.

Lancet Neurol 2019 Jul 16;18(7):623-624. Epub 2019 May 16.

Institute of Clinical Neuroimmunology, Ludwig Maximilians University, D-81377 Munich, Germany; Munich Cluster for Systems Neurology, Munich, Germany. Electronic address:

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http://dx.doi.org/10.1016/S1474-4422(19)30183-8DOI Listing
July 2019

Communication of CD8 T cells with mononuclear phagocytes in multiple sclerosis.

Ann Clin Transl Neurol 2019 07 14;6(7):1151-1164. Epub 2019 Jun 14.

Institute of Clinical Neuroimmunology, Biomedical Center and Hospital of the Ludwig-Maximilians-University Munich, D-82152, Munich, Germany.

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http://dx.doi.org/10.1002/acn3.783DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6649540PMC
July 2019

Managing Risks with Immune Therapies in Multiple Sclerosis.

Drug Saf 2019 05;42(5):633-647

Department of Neurology, Medical Faculty, Heinrich-Heine-University, Moorenstrasse 5, 40225, Düsseldorf, Germany.

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http://dx.doi.org/10.1007/s40264-018-0782-8DOI Listing
May 2019

Risks and risk management in modern multiple sclerosis immunotherapeutic treatment.

Ther Adv Neurol Disord 2019 1;12:1756286419836571. Epub 2019 Apr 1.

Department of Neurology with Institute of Translational Neurology, University of Münster, Building A1, Albert Schweitzer Campus 1, 48149 Münster, Germany.

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http://dx.doi.org/10.1177/1756286419836571DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6444778PMC
April 2019

Abundant glutamic acid decarboxylase (GAD)-reactive B cells in gad-antibody-associated neurological disorders.

Ann Neurol 2019 03 28;85(3):448-454. Epub 2019 Jan 28.

Institute of Clinical Neuroimmunology, University Hospital and Biomedical Center, Ludwig-Maximilians University Munich, Munich, Germany.

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http://dx.doi.org/10.1002/ana.25414DOI Listing
March 2019

Immune dysbalance in childhood multiple sclerosis: a 'chicken or the egg' conundrum.

Brain 2019 03;142(3):490-492

Institute of Clinical Neuroimmunology, Biomedical Center, Ludwig Maxilimians University of Munich, Germany.

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http://dx.doi.org/10.1093/brain/awz008DOI Listing
March 2019

Recurrence of disease activity during pregnancy after cessation of fingolimod in multiple sclerosis.

Mult Scler 2018 06 18;24(7):991-994. Epub 2017 Sep 18.

Institute of Clinical Neuroimmunology, Biomedical Center and University Hospital, Ludwig-Maximilians-Universität München, Munich, Germany.

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http://dx.doi.org/10.1177/1352458517731913DOI Listing
June 2018

B-cells as therapeutic targets in neuro-inflammatory diseases.

Clin Immunol 2018 01 21;186:51-53. Epub 2017 Jul 21.

Institute of Clinical Neuroimmunology, Biomedical Center and University Hospital, Ludwig Maximilians University Munich, Munich Cluster of Systems Neurology (SyNergy), Munich, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.clim.2017.07.013DOI Listing
January 2018

Inflammatory CNS disease caused by immune checkpoint inhibitors: status and perspectives.

Nat Rev Neurol 2017 Dec 6;13(12):755-763. Epub 2017 Nov 6.

INSERM U1043 - CNRS UMR 5282, Centre de Physiopathologie Toulouse-Purpan, Purpan Hospital, Place du Docteur Baylac TSA 40031, 31059 Toulouse Cedex 9, France, and the Department of Immunology, Hôpital Rangueil, 1, Avenue du Professeur Jean Poulhès - TSA 50032 - 31059 Toulouse Cedex 9, France.

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http://www.nature.com/doifinder/10.1038/nrneurol.2017.144
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http://dx.doi.org/10.1038/nrneurol.2017.144DOI Listing
December 2017

Patient-to-patient transmission of natalizumab-associated PML?

Mult Scler 2017 10 20;23(11):1564-1565. Epub 2017 Mar 20.

Institute of Clinical Neuroimmunology, Biomedical Center and University Hospital, Ludwig Maximilians University, Munich, Germany; Munich Cluster for Systems Neurology (SyNergy), Ludwig Maximilians University, Munich, Germany.

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http://dx.doi.org/10.1177/1352458517701316DOI Listing
October 2017

Stop inflammation and you stop neurodegeneration in MS - Commentary.

Mult Scler 2017 09 2;23(10):1323-1324. Epub 2017 May 2.

Institute of Clinical Neuroimmunology, Biomedical Center and University Hospital, Ludwig-Maximilians-University Munich, Munich, Germany/ Munich Cluster of Systems Neurology (SyNergy), Ludwig-Maximilians-University Munich, Munich, Germany.

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http://dx.doi.org/10.1177/1352458517707587DOI Listing
September 2017

Visualizing context-dependent calcium signaling in encephalitogenic T cells in vivo by two-photon microscopy.

Proc Natl Acad Sci U S A 2017 08 17;114(31):E6381-E6389. Epub 2017 Jul 17.

Institute of Clinical Neuroimmunology, University Hospital and Biomedical Center, Ludwig-Maximilians University Munich, 81377 Munich, Germany;

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http://dx.doi.org/10.1073/pnas.1701806114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5547602PMC
August 2017

T Cell-Transfer Experimental Autoimmune Encephalomyelitis: Pillar of Multiple Sclerosis and Autoimmunity.

J Immunol 2017 05;198(9):3381-3383

Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA 94305.

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http://dx.doi.org/10.4049/jimmunol.1700346DOI Listing
May 2017

Human Plasmacytoid Dendritic Cells Display and Shed B Cell Maturation Antigen upon TLR Engagement.

J Immunol 2017 04 10;198(8):3081-3088. Epub 2017 Mar 10.

Institute of Clinical Neuroimmunology, Biomedical Center and University Hospitals, LMU Munich, 82152 Planegg-Martinsried, Germany;

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http://dx.doi.org/10.4049/jimmunol.1601746DOI Listing
April 2017

Ocrelizumab in multiple sclerosis: markers and mechanisms.

Lancet Neurol 2017 04;16(4):259-261

Institute of Clinical Neuroimmunology, University Hospitals and Biomedical Center, Ludwig Maximilians University, Munich, Germany; Munich Cluster of Systems Neurology (SyNergy), Munich, Germany.

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http://dx.doi.org/10.1016/S1474-4422(17)30048-0DOI Listing
April 2017

Dynamic Contrast-Enhanced Magnetic Resonance Imaging Suggests Normal Perfusion in Normal-Appearing White Matter in Multiple Sclerosis.

Invest Radiol 2017 03;52(3):135-141

From the *Josef Lissner Laboratory for Biomedical Imaging, Institute for Clinical Radiology, Ludwig-Maximilians-University Hospital Munich, Munich, Germany; †Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, Leeds, United Kingdom; ‡Institute for Clinical Radiology, and §Institute of Clinical Neuroimmunology, Ludwig-Maximilians-University Hospital; and ∥Munich Cluster for Systems Neurology (SyNergy), Munich, Germany.

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http://dx.doi.org/10.1097/RLI.0000000000000320DOI Listing
March 2017

Interdisciplinary Risk Management in the Treatment of Multiple Sclerosis.

Dtsch Arztebl Int 2016 Dec;113(51-52):879-886

Institute for Clinical Neuroimmunology, Biomedical Center and Hospital, Ludwig-Maximilians Universität München, Munich; Department of Neurology, Faculty of Medicine, Heinrich Heine University Düsseldorf; Department of Neurology, University Hospital Basel; Munich Cluster for Systems Neurology (SyNergy).

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http://dx.doi.org/10.3238/arztebl.2016.0879DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5282476PMC
December 2016

Autoantibodies to MOG in a distinct subgroup of adult multiple sclerosis.

Neurol Neuroimmunol Neuroinflamm 2016 Oct 30;3(5):e257. Epub 2016 Jun 30.

Institute of Clinical Neuroimmunology (M.S., L.A.G., M.K., F.S.T., E.S., R.H., E.M., T.K.), Department of Radiology (B.E.-W.), and Laboratory for Immunogenetics (A.D.), Medical Campus Großhadern, Ludwig-Maximilians-Universität München; Department of Neurology (M.K.), Hertie Institut für klinische Hirnforschung, Universitätsklinikum Tübingen; Department of Neuropathology (I.M., W.B.), University Medical Center, Georg August University, Göttingen; Department of Paediatric Neurology and Developmental Medicine (A.B.), Dr. von Hauner Children's Hospital, Ludwig-Maximilians-Universität München; and Munich Cluster for Systems Neurology (SyNergy) (R.H.), Munich, Germany.

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http://dx.doi.org/10.1212/NXI.0000000000000257DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4949775PMC
October 2016

Antiglutamatergic therapy for multiple sclerosis?

Lancet Neurol 2016 09 8;15(10):1003-4. Epub 2016 Aug 8.

Institute of Clinical Neuroimmunology, Biomedical Centre and University Hospital, Ludwig Maximilians University, Munich D-81377, Germany; Munich Cluster of Systems Neurology (SyNergy), Munich, Germany.

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http://dx.doi.org/10.1016/S1474-4422(16)30163-6DOI Listing
September 2016

Mitochondrial DNA Variation and Heteroplasmy in Monozygotic Twins Clinically Discordant for Multiple Sclerosis.

Hum Mutat 2016 08 13;37(8):765-75. Epub 2016 May 13.

Department of Genetics/Epigenetics, Saarland University, Saarbrücken, Germany.

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http://dx.doi.org/10.1002/humu.23003DOI Listing
August 2016

Multiple sclerosis: Molecular mimicry of an antimyelin HLA class I restricted T-cell receptor.

Neurol Neuroimmunol Neuroinflamm 2016 Aug 17;3(4):e241. Epub 2016 May 17.

Institute of Clinical Neuroimmunology (G.R., A.G.N., K.S., R.H., K.D.) and Munich Cluster for Systems Neurology (SyNergy) (R.H., K.D.), Ludwig-Maximilian-University, Munich; Department of Life Sciences (A.P., M.K., I.A.), Technical University Munich, Freising; Max Planck Institute of Biochemistry (S.P.), Martinsried; Institute of Neuroimmunology and Multiple Sclerosis (M.A.F.), University Medical Centre, Hamburg-Eppendorf, Hamburg, Germany; MRC Human Immunology Unit (K.E.A.), Radcliffe Department of Medicine, Weatherall, Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, UK; and Center for Integrated Protein Science Munich (CIPSM) (I.A.), Germany.

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http://dx.doi.org/10.1212/NXI.0000000000000241DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4871805PMC
August 2016

CTLA4 as Immunological Checkpoint in the Development of Multiple Sclerosis.

Ann Neurol 2016 Aug 15;80(2):294-300. Epub 2016 Jul 15.

Institute of Clinical Neuroimmunology, Biomedical Center and University Hospital, Grosshadern-Martinsried Campus, Ludwig Maximilian University, Munich.

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http://dx.doi.org/10.1002/ana.24715DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5129566PMC
August 2016

Features of Human CD3+CD20+ T Cells.

J Immunol 2016 08 13;197(4):1111-7. Epub 2016 Jul 13.

Institute of Clinical Neuroimmunology, Biomedical Center and University Hospital, Ludwig Maximilian University, 82152 Martinsried, Germany;

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http://dx.doi.org/10.4049/jimmunol.1600089DOI Listing
August 2016

Distinct oligoclonal band antibodies in multiple sclerosis recognize ubiquitous self-proteins.

Proc Natl Acad Sci U S A 2016 07 20;113(28):7864-9. Epub 2016 Jun 20.

Institute of Clinical Neuroimmunology, Ludwig-Maximilians-University, 81377 Munich, Germany; Munich Cluster for Systems Neurology (SyNergy), Ludwig-Maximilians-University, 81377 Munich, Germany

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http://www.pnas.org/content/early/2016/06/15/1522730113.full
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http://www.pnas.org/lookup/doi/10.1073/pnas.1522730113
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http://dx.doi.org/10.1073/pnas.1522730113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4948369PMC
July 2016

Alemtuzumab and Multiple Sclerosis: Another Note of Caution.

JAMA Neurol 2016 06;73(6):637-8

Institute of Clinical Neuroimmunology, Biomedical Center and Klinikum Grosshadern, Munich, Germany.

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http://dx.doi.org/10.1001/jamaneurol.2016.0259DOI Listing
June 2016

Impaired NK-mediated regulation of T-cell activity in multiple sclerosis is reconstituted by IL-2 receptor modulation.

Proc Natl Acad Sci U S A 2016 May 9;113(21):E2973-82. Epub 2016 May 9.

Department of Neurology, University Hospital Münster, Muenster D-48149, Germany; Cluster of Excellence EXC 1003, Cells in Motion, Westfälische Wilhelms-University, 48149 Muenster, Germany

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http://dx.doi.org/10.1073/pnas.1524924113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4889377PMC
May 2016

Cytotoxic T cells go awry in inclusion body myositis.

Brain 2016 05;139(Pt 5):1312-4

Division of Rheumatology and Clinical Immunology, Department of Internal Medicine IV, Campus Innenstadt, Ludwig Maximilians University, Munich, Germany.

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http://brain.oxfordjournals.org/content/brain/139/5/1312.ful
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http://www.brain.oxfordjournals.org/lookup/doi/10.1093/brain
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http://dx.doi.org/10.1093/brain/aww053DOI Listing
May 2016

The search for the target antigens of multiple sclerosis, part 2: CD8+ T cells, B cells, and antibodies in the focus of reverse-translational research.

Lancet Neurol 2016 Mar 24;15(3):317-31. Epub 2015 Dec 24.

HERTIE Senior Professor Group Neuroimmunology, Max Planck Institute of Neurobiology, Martinsried, Germany.

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http://dx.doi.org/10.1016/S1474-4422(15)00313-0DOI Listing
March 2016

The search for the target antigens of multiple sclerosis, part 1: autoreactive CD4+ T lymphocytes as pathogenic effectors and therapeutic targets.

Lancet Neurol 2016 02 24;15(2):198-209. Epub 2015 Dec 24.

HERTIE Senior Professor Group Neuroimmunology, Max Planck Institute of Neurobiology, Martinsried, Germany.

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http://dx.doi.org/10.1016/S1474-4422(15)00334-8DOI Listing
February 2016

Pro-inflammatory pattern of IgG1 Fc glycosylation in multiple sclerosis cerebrospinal fluid.

J Neuroinflammation 2015 Dec 18;12:235. Epub 2015 Dec 18.

Institute of Clinical Neuroimmunology, Biomedical Center (BMC) and University Hospital, Campus Martinsried-Grosshadern, LMU Munich, Munich, Germany.

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http://dx.doi.org/10.1186/s12974-015-0450-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4683913PMC
December 2015

T-cell receptor repertoire of human peripheral CD161hiTRAV1-2+ MAIT cells revealed by next generation sequencing and single cell analysis.

Hum Immunol 2015 Sep 14;76(9):607-14. Epub 2015 Sep 14.

Institute of Clinical Neuroimmunology, Klinikum der Universität Muenchen, Munich, Germany; Munich Cluster for Systems Neurology (SyNergy), Ludwig-Maximilian-University, Munich, Germany.

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http://dx.doi.org/10.1016/j.humimm.2015.09.002DOI Listing
September 2015

Fingolimod induces neuroprotective factors in human astrocytes.

J Neuroinflammation 2015 Sep 30;12:184. Epub 2015 Sep 30.

Institute of Clinical Neuroimmunology, Ludwig Maximilian University, 81377, Munich, Germany.

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http://dx.doi.org/10.1186/s12974-015-0393-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4589103PMC
September 2015

αβ T-cell receptors from multiple sclerosis brain lesions show MAIT cell-related features.

Neurol Neuroimmunol Neuroinflamm 2015 Aug 7;2(4):e107. Epub 2015 May 7.

Institute of Clinical Neuroimmunology (K.H., L.B.-D., K.S., W.S., E.B., G.R., J.K.M.N., R.H., K.D.), Ludwig-Maximilians University, Munich, Germany; Neurologische Gemeinschaftspraxis (S.S.), Gesundheitszentrum St. Johannes Hospital, Bonn, Germany; Institute of Neuronal Cell Biology (P.E., T.M.), TU Munich, Munich, Germany; Department for Molecular Medicine (M.M.), Max-Planck-Institute of Biochemistry, Martinsried, Germany; Department for Neuroimmunology (W.E.F.K., H.W.), Max-Planck-Institute of Neurobiology, Martinsried, Germany; Department of Genetics (H.B.), Harvard Medical School, Boston, MA; Munich Cluster for Systems Neurology (SyNergy) (T.M., H.W., R.H., K.D.), Munich, Germany; German Center for Neurodegenerative Diseases (DZNE) and Center for Integrated Protein Science (CIPSM) (T.M.), Munich, Germany; and INSERM, UMR 1064 (D.A.L.), Nantes, France.

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http://dx.doi.org/10.1212/NXI.0000000000000107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4426681PMC
August 2015

Expanding spectrum of neurologic manifestations in patients with NLRP3 low-penetrance mutations.

Neurol Neuroimmunol Neuroinflamm 2015 Aug 14;2(4):e109. Epub 2015 May 14.

Institute of Clinical Neuroimmunology (E.S., M.K., L.-A.G., R.H., T.K.), Institute of Clinical Radiology (B.E.-W.), and Department of Rheumatology (M.W.), Ludwig-Maximillians University, Munich, Germany; Department of Neuroimmunology (E.S.), Center of Brain Research, Vienna, Austria; Institute of Laboratory Medicine and Human Genetics (P.L.), Singen, Germany; Comprehensive Pneumology Center (M.F.) (Ludwig-Maximilians University Munich, Asklepios Kliniken Gauting, Helmholtz Zentrum München, Germany); and Munich Cluster for Systems Neurology (SyNergy) (R.H.), Munich, Germany.

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http://dx.doi.org/10.1212/NXI.0000000000000109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4436598PMC
August 2015

Long-term effects of fingolimod in multiple sclerosis: the randomized FREEDOMS extension trial.

Neurology 2015 Apr 20;84(15):1582-91. Epub 2015 Mar 20.

From the Department of Neurology (L.K.), University Hospital, Basel, Switzerland; St. Michael's Hospital (P.O.'C.), Toronto, Canada; Medical Image Analysis Centre (E.-W.R.), University Hospital, University of Basel, Switzerland; Department of Neurology (C.P.), VU University Medical Center, Amsterdam, Netherlands; Ludwig-Maximilians University of Munich and Munich Cluster for Systems Neurology (SyNergy) (R.H.), Germany; Department of Neurology (K.S.), Medical University of Lodz, Poland; Novartis Pharmaceuticals Corporation (S.R., G.F.), East Hanover, NJ; and Novartis Pharma AG (R.S., P.v.R., L.Z.-A.), Basel, Switzerland.

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http://dx.doi.org/10.1212/WNL.0000000000001462DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4408283PMC
April 2015

Histopathology and clinical course of MOG-antibody-associated encephalomyelitis.

Ann Clin Transl Neurol 2015 Mar 14;2(3):295-301. Epub 2015 Jan 14.

Institute of Clinical Neuroimmunology, Medical Campus Grosshadern, Ludwig Maximilian University Munich, Germany.

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http://dx.doi.org/10.1002/acn3.164DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4369279PMC
March 2015

Multiple sclerosis-like lesions and type I interferon signature in a patient with RVCL.

Neurol Neuroimmunol Neuroinflamm 2015 Feb 23;2(1):e55. Epub 2014 Dec 23.

Institute of Clinical Neuroimmunology (E.S., R.H., T.K.) and Institute of Clinical Radiology (B.E.-W.), Ludwig-Maximilians University, Munich, Germany; Department of Neuroimmunology (E.S.), Center of Brain Research, Vienna, Austria; Institute of Laboratory Medicine and Human Genetics (P.L.), Singen, Germany; Department of Ophthalmology (W.W.), Outpatient Clinic Neuhann, Munich, Germany; Department of Nephrology (J.F.M.), Clinical Centre Schwabing, Munich, Germany; Department of Pediatrics (M.A.L.-K.), Technische Universität Dresden, Germany; and Munich Cluster for Systems Neurology (SyNergy) (R.H.), Munich, Germany.

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http://dx.doi.org/10.1212/NXI.0000000000000055DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4277301PMC
February 2015

From classic to spontaneous and humanized models of multiple sclerosis: impact on understanding pathogenesis and drug development.

J Autoimmun 2014 Nov 28;54:33-50. Epub 2014 Aug 28.

Department of Neuroimmunology, Max Planck Institute of Neurobiology, Martinsried 82152, Germany. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S08968411140010
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http://dx.doi.org/10.1016/j.jaut.2014.06.004DOI Listing
November 2014

Intrathecal somatic hypermutation of IgM in multiple sclerosis and neuroinflammation.

Brain 2014 Oct 23;137(Pt 10):2703-14. Epub 2014 Jul 23.

1 Institute of Clinical Neuroimmunology, University Hospital Grosshadern, LMU Munich, D-81377 Munich, Germany 7 Munich Cluster for Systems Neurology (SyNergy), Adolf-Butenandt-Institut, Ludwig-Maximilians-Universität München, 80336 München, Germany

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http://dx.doi.org/10.1093/brain/awu205DOI Listing
October 2014

Unusual natalizumab-associated progressive multifocal leukoencephalopathy starting in the brainstem.

J Neurol 2014 Jan 26;261(1):232-4. Epub 2013 Nov 26.

Institute of Clinical Neuroimmunology, Ludwig-Maximilians-University, Medical Campus Grosshadern, Marchioninistr. 15, 81377, Munich, Germany,

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http://dx.doi.org/10.1007/s00415-013-7191-9DOI Listing
January 2014

[New approaches for the treatment of neurological diseases].

Drug Res (Stuttg) 2013 Nov 15;63 Suppl 1:S1-2. Epub 2013 Nov 15.

Ludwig-Maximilians-Universität München.

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http://dx.doi.org/10.1055/s-0033-1346719DOI Listing
November 2013

TNFRSF1A in multiple sclerosis: a tale of soluble receptors and signaling cascades.

Neurology 2013 Nov 30;81(22):1886-8. Epub 2013 Oct 30.

From the Department of Neurology (P.J.T.), Biomedicum, Research Programs Unit, Molecular Neurology, Helsinki University Central Hospital and University of Helsinki, Finland; and the Institute of Clinical Neuroimmunology (R.H.), Ludwig Maximilians University, Munich, and Munich Cluster for Systems Neurology (SyNergy) (R.H.), Munich, Germany.

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http://dx.doi.org/10.1212/01.wnl.0000436624.56026.ebDOI Listing
November 2013

Natalizumab-induced PML: can the beast be tamed?

J Neurol Neurosurg Psychiatry 2013 Oct 9;84(10):1065. Epub 2013 Mar 9.

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http://dx.doi.org/10.1136/jnnp-2013-305077DOI Listing
October 2013

A bird's-eye view of T cells during natalizumab therapy.

Neurology 2013 Oct 18;81(16):1372-3. Epub 2013 Sep 18.

From the Institute of Clinical Neuroimmunology (R.H.), Ludwig Maximilians University, Munich; Munich Cluster for Systems Neurology (SyNergy) (R.H.), Germany; and University of Texas Southwestern Medical Center and Neurology Section (O.S.), VA North Texas Health Care Systems, Dallas.

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http://dx.doi.org/10.1212/WNL.0b013e3182a84207DOI Listing
October 2013

Fingolimod reduces recurrence of disease activity after natalizumab withdrawal in multiple sclerosis.

J Neurol 2013 May 25;260(5):1382-7. Epub 2012 Dec 25.

Institute of Clinical Neuroimmunology, Medical Campus Grosshadern, Ludwig-Maximilians-University, Marchioninistr. 15, 81377 Munich, Germany.

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http://dx.doi.org/10.1007/s00415-012-6808-8DOI Listing
May 2013

Therapies for multiple sclerosis: translational achievements and outstanding needs.

Trends Mol Med 2013 May 10;19(5):309-19. Epub 2013 Apr 10.

Nuffield Department of Clinical Neurosciences and MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford, UK.

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http://dx.doi.org/10.1016/j.molmed.2013.03.004DOI Listing
May 2013

Symptoms related to tumor necrosis factor receptor 1-associated periodic syndrome, multiple sclerosis, and severe rheumatoid arthritis in patients carrying the TNF receptor superfamily 1A D12E/p.Asp41Glu mutation.

J Rheumatol 2013 Mar 15;40(3):261-4. Epub 2013 Jan 15.

Institute of Clinical Neuroimmunology and the Department of Clinical Chemistry, Ludwig-Maximilians University, Munich, Germany.

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http://dx.doi.org/10.3899/jrheum.120729DOI Listing
March 2013

Ion channels boost axonal injury in multiple sclerosis.

Nat Med 2012 Dec;18(12):1743-5

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http://dx.doi.org/10.1038/nm.3021DOI Listing
December 2012

B cells and antibodies in multiple sclerosis pathogenesis and therapy.

Nat Rev Neurol 2012 Nov 9;8(11):613-23. Epub 2012 Oct 9.

Institute of Clinical Neuroimmunology, Ludwig Maximilian University Munich, Germany.

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http://dx.doi.org/10.1038/nrneurol.2012.203DOI Listing
November 2012

Prospects of transcript profiling for mRNAs and MicroRNAs using formalin-fixed and paraffin-embedded dissected autoptic multiple sclerosis lesions.

Brain Pathol 2012 Sep 13;22(5):607-18. Epub 2012 Feb 13.

Institute of Clinical Neuroimmunology, University Hospital Großhadern, Ludwig-Maximilians-University, Munich, Germany.

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http://dx.doi.org/10.1111/j.1750-3639.2012.00564.xDOI Listing
September 2012

Viability of autoantibody-targets: how to tackle pathogenetic heterogeneity as an obstacle for treatment of multiple sclerosis.

J Neurol Sci 2012 Aug 28;319(1-2):2-7. Epub 2012 May 28.

Max Planck Institute of Neurobiology, Department of Neuroimmunology, Martinsried, Germany.

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http://linkinghub.elsevier.com/retrieve/pii/S0022510X1200229
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http://dx.doi.org/10.1016/j.jns.2012.05.018DOI Listing
August 2012

β-Amyloid: enemy or remedy?

Sci Transl Med 2012 Aug;4(145):145fs24

Institute of Clinical Neuroimmunology, Ludwig Maximilians University, Munich D-81377, Germany.

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http://dx.doi.org/10.1126/scitranslmed.3004586DOI Listing
August 2012

Non-specific alterations of craniocervical venous drainage in multiple sclerosis revealed by cardiac-gated phase-contrast MRI.

Mult Scler 2012 Jul 22;18(7):1000-7. Epub 2011 Dec 22.

Institute of Clinical Radiology, University of Munich - Grosshadern Campus, Ludwig-Maximilians-University Munich, Germany.

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http://dx.doi.org/10.1177/1352458511432742DOI Listing
July 2012

Target specificity of an autoreactive pathogenic human γδ-T cell receptor in myositis.

J Biol Chem 2012 Jun 1;287(25):20986-95. Epub 2012 May 1.

Institute of Clinical Neuroimmunology, Ludwig Maximilians University, D-81377 Munich, Germany.

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http://dx.doi.org/10.1074/jbc.M112.356709DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3375522PMC
June 2012

Unbiased identification of target antigens of CD8+ T cells with combinatorial libraries coding for short peptides.

Nat Med 2012 May;18(5):824-8

Institute of Clinical Neuroimmunology, Ludwig-Maximilians-University, Munich, Germany.

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http://dx.doi.org/10.1038/nm.2720DOI Listing
May 2012

Quantification of perfusion and permeability in multiple sclerosis: dynamic contrast-enhanced MRI in 3D at 3T.

Invest Radiol 2012 Apr;47(4):252-8

Josef Lissner Laboratory for Biomedical Imaging, Department of Clinical Radiology, University Hospitals Munich-Grosshadern, Ludwig Maximilian University of Munich, Germany.

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http://dx.doi.org/10.1097/RLI.0b013e31823bfc97DOI Listing
April 2012

What T-cell receptors can tell us about neurologic disease.

Neurology 2012 Feb 11;78(6):376-7. Epub 2012 Jan 11.

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http://dx.doi.org/10.1212/WNL.0b013e318245d2f5DOI Listing
February 2012

Rebound of disease activity after withdrawal of fingolimod (FTY720) treatment.

Arch Neurol 2012 Feb;69(2):262-4

Institute of Clinical Neuroimmunology, Ludwig-Maximilians-University, Marchioninistr 15, 81377 Munich, Germany.

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http://dx.doi.org/10.1001/archneurol.2011.1057DOI Listing
February 2012

Update on sporadic inclusion body myositis.

Brain 2011 Nov 29;134(Pt 11):3141-5. Epub 2011 Sep 29.

Institute of Clinical Neuroimmunology, Ludwig Maximilians University of Munich, Campus Grosshadern, Munich, Germany.

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http://dx.doi.org/10.1093/brain/awr258DOI Listing
November 2011

De-escalation from natalizumab in multiple sclerosis: recurrence of disease activity despite switching to glatiramer acetate.

J Neurol 2011 Sep 23;258(9):1665-9. Epub 2011 Mar 23.

Institute of Clinical Neuroimmunology, Medical Campus Grosshadern, Ludwig-Maximilians-University, Marchioninistr. 15, 81377 Munich, Germany.

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http://link.springer.com/10.1007/s00415-011-5996-y
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September 2011

Humoral autoimmunity in multiple sclerosis.

J Neurol Sci 2011 Jul 3;306(1-2):180-2. Epub 2010 Sep 3.

Department of Neuroimmunology, Max Planck Institute of Neurobiology, Am Klopferspitz 18, 82152 Martinsried, Germany.

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http://dx.doi.org/10.1016/j.jns.2010.08.009DOI Listing
July 2011

Multiple sclerosis: Cladribine--a contentious therapeutic contender for MS.

Nat Rev Neurol 2011 Jul 12;7(8):425-7. Epub 2011 Jul 12.

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http://www.nature.com/articles/nrneurol.2011.105
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July 2011

[Multiple sclerosis: can therapy delay ongoing disability?].

MMW Fortschr Med 2011 Apr;153(14):63-6

Institut für Klinische Neuroimmunologie, Klinikum der Universität München, Grosshadern, Ludwig-Maximilians-Universität München.

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April 2011

Future clinical challenges in multiple sclerosis: Relevance to sphingosine 1-phosphate receptor modulator therapy.

Neurology 2011 Feb;76(8 Suppl 3):S28-37

Institute for Clinical Neuroimmunology, Munich, Germany.

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http://dx.doi.org/10.1212/WNL.0b013e31820db40fDOI Listing
February 2011

Modulation of sphingosine 1-phosphate signaling in neurologic disease.

Neurology 2011 Feb;76(8 Suppl 3):S1-2

Montreal Neurological Institute, McGill University, Quebec, Canada.

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http://dx.doi.org/10.1212/wnl.0b013e31820d5e55DOI Listing
February 2011

The emerging role of microRNAs in multiple sclerosis.

Nat Rev Neurol 2011 Jan 14;7(1):56-9. Epub 2010 Dec 14.

Department of Neuropathology, University Medical Center, Georg August University, Robert-Koch-Strasse 40, 37075 Göttingen, Germany.

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http://dx.doi.org/10.1038/nrneurol.2010.179DOI Listing
January 2011

Axo-glial antigens as targets in multiple sclerosis: implications for axonal and grey matter injury.

J Mol Med (Berl) 2010 Aug 6;88(8):753-61. Epub 2010 May 6.

Department of Neurology, Friedrich-Alexander-University, Schwabachanlage 6, 91054, Erlangen, Germany.

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http://dx.doi.org/10.1007/s00109-010-0632-3DOI Listing
August 2010

Beneficial brain autoimmunity?

Brain 2010 Aug;133(Pt 8):2182-4

Max Planck Institute for Neurobiologie, Martinsried, Germany.

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http://dx.doi.org/10.1093/brain/awq206DOI Listing
August 2010