Reiner Siebert

Reiner Siebert

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Reiner Siebert

Reiner Siebert

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How I approach hereditary cancer predisposition in a child with cancer.

Pediatr Blood Cancer 2019 Nov 24;66(11):e27916. Epub 2019 Jul 24.

University Children's Hospital Augsburg, Swabian Children's Cancer Center, Augsburg, Germany.

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http://dx.doi.org/10.1002/pbc.27916DOI Listing
November 2019

Further evidence that full gene deletions of DICER1 predispose to DICER1 syndrome.

Genes Chromosomes Cancer 2019 08 28;58(8):602-604. Epub 2019 Jan 28.

Department of Human Genetics, McGill University, Montréal, Québec, Canada.

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http://dx.doi.org/10.1002/gcc.22728DOI Listing
August 2019

FISH and FICTION in Lymphoma Research.

Methods Mol Biol 2019 ;1956:249-267

Institute of Human Genetics, Ulm University and Ulm University Medical Center, Ulm, Germany.

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http://dx.doi.org/10.1007/978-1-4939-9151-8_11DOI Listing
July 2019

Non-leukemic pediatric mixed phenotype acute leukemia/lymphoma: Genomic characterization and clinical outcome in a prospective trial for pediatric lymphoblastic lymphoma.

Genes Chromosomes Cancer 2019 06 21;58(6):365-372. Epub 2019 Jan 21.

Department of Pathology, Hematopathology Section and Lymph Node Registry, University Hospital Schleswig-Holstein, Campus Kiel/Christian-Albrechts University, Kiel, Germany.

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http://dx.doi.org/10.1002/gcc.22726DOI Listing
June 2019

Mesenchymal Hamartoma of the Liver and DICER1 Syndrome.

N Engl J Med 2019 05;380(19):1834-1842

From the Departments of Human Genetics (M.A.-R., M.K.W., W.D.F.), Pharmacology (D.P.), Oncology (M.R.F., W.D.F.), and Biochemistry (M.R.F.), and the Lady Davis Institute, Segal Cancer Centre, Jewish General Hospital (M.A.-R., D.P., N.S., M.K.W., M.R.F., W.D.F.), McGill University, the Department of Pathology, Montreal Children's Hospital (V.-H.N.), the Department of Radiology (K.M.), and the Cancer Research Program, Research Institute (W.D.F.), McGill University Health Centre, and the Department of Pathology, Centre Hospitalier Universitaire Sainte-Justine (D.B.-D.S.) - all in Montreal; the Department of Pediatrics, Endocrinology Unit, Sapienza University, Rome (M.S.), and Centro Diagnostico Italiano, Milan (S.Z.) - both in Italy; the Department of Pediatrics and Adolescent Medicine, Faculty of Medicine (M.K.), and the Institute for Diagnostic and Interventional Radiology, Faculty of Medicine (J.M.), Georg-August University, Göttingen, the Department of Pediatric Surgery, St. Bernward Krankenhaus Hildesheim, Hildesheim (S.G.), and the Institute of Human Genetics, Ulm University and Ulm University Medical Center, Ulm (R.W., C.L., R.S.) - all in Germany; and Minneapolis (J.R.P.).

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http://www.nejm.org/doi/10.1056/NEJMoa1812169
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http://dx.doi.org/10.1056/NEJMoa1812169DOI Listing
May 2019

Points-to-consider on the return of results in epigenetic research.

Genome Med 2019 05 23;11(1):31. Epub 2019 May 23.

Centre of Genomics and Policy, Faculty of Medicine, McGill University, Montreal, Quebec, H3A 0G1, Canada.

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http://dx.doi.org/10.1186/s13073-019-0646-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6533659PMC
May 2019

Family-based germline sequencing in children with cancer.

Oncogene 2019 02 10;38(9):1367-1380. Epub 2018 Oct 10.

Department of Pediatric Oncology, Hematology and Clinical Immunology, University Children's Hospital, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany.

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http://dx.doi.org/10.1038/s41388-018-0520-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6755997PMC
February 2019

gene mutations are frequently detected in in situ follicular neoplasia.

Blood 2018 12 6;132(25):2687-2690. Epub 2018 Nov 6.

Institute of Pathology and Neuropathology, Eberhard Karls University of Tübingen and Comprehensive Cancer Center, University Hospital Tübingen, Tübingen, Germany.

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http://www.bloodjournal.org/lookup/doi/10.1182/blood-2018-03
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http://dx.doi.org/10.1182/blood-2018-03-837039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6302496PMC
December 2018

RBFOX2 and alternative splicing in B-cell lymphoma.

Blood Cancer J 2018 08 10;8(8):77. Epub 2018 Aug 10.

Department of Human and Animal Cell Lines, Leibniz-Institute DSMZ-German Collection of Microorganisms and Cell Cultures, Braunschweig, Germany.

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http://dx.doi.org/10.1038/s41408-018-0114-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6086906PMC
August 2018

Author Correction: The landscape of genomic alterations across childhood cancers.

Nature 2018 07;559(7714):E10

Hopp-Children's Cancer Center at the NCT Heidelberg (KiTZ), Heidelberg, Germany.

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http://dx.doi.org/10.1038/s41586-018-0167-2DOI Listing
July 2018

Mosaic genome-wide maternal isodiploidy: an extreme form of imprinting disorder presenting as prenatal diagnostic challenge.

Clin Epigenetics 2017 13;9:111. Epub 2017 Oct 13.

Institute of Human Genetics, University of Ulm & Ulm University Hospital, Albert-Einstein-Allee 11, D-89081 Ulm, Germany.

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http://dx.doi.org/10.1186/s13148-017-0410-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5640928PMC
May 2018

The landscape of genomic alterations across childhood cancers.

Nature 2018 03 28;555(7696):321-327. Epub 2018 Feb 28.

Hopp-Children's Cancer Center at the NCT Heidelberg (KiTZ), Heidelberg, Germany.

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http://dx.doi.org/10.1038/nature25480DOI Listing
March 2018

Opposing Effects of CREBBP Mutations Govern the Phenotype of Rubinstein-Taybi Syndrome and Adult SHH Medulloblastoma.

Dev Cell 2018 03 15;44(6):709-724.e6. Epub 2018 Mar 15.

Center for Neuropathology, Ludwig-Maximilians-University, 81377 Munich, Germany; Research Institute Children's Cancer Center Hamburg, Martinistrasse 52, N63 (HPI), Hamburg 20251, Germany; Institute of Neuropathology, University Medical Center, Hamburg-Eppendorf, 20246 Hamburg, Germany; Department of Pediatric Hematology and Oncology, University Medical Center, Hamburg-Eppendorf, 20246 Hamburg, Germany. Electronic address:

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http://dx.doi.org/10.1016/j.devcel.2018.02.012DOI Listing
March 2018

MYC expression and translocation analyses in low-grade and transformed follicular lymphoma.

Histopathology 2017 Dec 17;71(6):960-971. Epub 2017 Oct 17.

Department of Haematology, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands.

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http://doi.wiley.com/10.1111/his.13316
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http://dx.doi.org/10.1111/his.13316DOI Listing
December 2017

Cell-of-origin classification by gene expression and MYC-rearrangements in diffuse large B-cell lymphoma of children and adolescents.

Br J Haematol 2017 10 23;179(1):116-119. Epub 2017 Jun 23.

Department of Pathology, Haematopathology Section and Lymph Node Registry, University Hospital Schleswig-Holstein, Campus Kiel/Christian-Albrecht University, Kiel, Germany.

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http://dx.doi.org/10.1111/bjh.14812DOI Listing
October 2017

Abstracts of the 52nd Workshop for Pediatric Research : Frankfurt, Germany. 27-28 October 2016.

Authors:
Rhea van den Bruck Patrick P Weil Thomas Ziegenhals Philipp Schreiner Stefan Juranek Daniel Gödde Silvia Vogel Frauke Schuster Valerie Orth Johannes Dörner Daniel Pembaur Meike Röper Stefan Störkel Hubert Zirngibl Stefan Wirth Andreas C W Jenke Jan Postberg Nikolas Boy Jana Heringer Gisela Haege Esther M Glahn Georg F Hoffmann Sven F Garbade Peter Burgard Stefan Kölker Cho-Ming Chao Faady Yahya Alena Moiseenko Amit Shrestha Negah Ahmadvand Jennifer Quantius Jochen Wilhelm Elie El-Agha Klaus-Peter Zimmer Saverio Bellusci Christian Staufner Stefan Kölker Holger Prokisch Georg F Hoffmann Stephan Seeliger Matthias Müller Andreas Hippe Henrik Steinkraus Roland Wauer Burkhard Lachmann Sigrun R Hofmann Christian M Hedrich Jakob Zierk Farhad Arzideh Rainer Haeckel Wolfgang Rascher Manfred Rauh Markus Metzler Sebastian Thieme Joanna Bandoła Cornelia Richter Martin Ryser Arshad Jamal Michelle P Ashton Malte von Bonin Matthias Kuhn Christian M Hedrich Ezio Bonifacio Reinhard Berner Sebastian Brenner Johanna Hammersen Cristina Has Nora Naumann-Bartsch Daniel Stachel Dimitra Kiritsi Stephan Söder Mathilde Tardieu Markus Metzler Leena Bruckner-Tuderman Holm Schneider F Bohne D Langer R Cencic T Eggermann U Zechner J Pelletier F Zepp T Enklaar D Prawitt Martin Pech Markus Weckmann Femke-Anouska Heinsen Andre Franke Christine Happle Anna-Maria Dittrich Gesine Hansen Oliver Fuchs Erika von Mutius Brian G Oliver Matthias V Kopp Claudia Paret Alexandra Russo Johanna Theruvath Bettina Keller Khalifa El Malki Nadine Lehmann Arthur Wingerter Marie A Neu Gerhold-Ay Aslihan Wolfgang Wagner Clemens Sommer Torsten Pietsch Larissa Seidmann Jörg Faber Felix Schreiner Merle Ackermann Michael Michalik Eva Rother Andras Bilkei-Gorzo Ildiko Racz Laura Bindila Beat Lutz Jörg Dötsch Andreas Zimmer Joachim Woelfle Hendrik S Fischer Tim L Ullrich Christoph Bührer Christoph Czernik Gerd Schmalisch Robert Stein Sigrun R Hofmann Judith Hagenbuchner Ursula Kiechl-Kohlendorfer Petra Obexer Michael J Ausserlechner Niki T Loges Adrien Tobias Frommer Julia Wallmeier Heymut Omran Soner Öner-Sieben Martina Gimpfl Jan Rozman Martin Irmler Johannes Beckers Martin Hrabe De Angelis Adelbert Roscher Eckhard Wolf Regina Ensenauer Karolina Nemes Michael Frühwald Martin Hasselblatt Reiner Siebert Uwe Kordes Marcel Kool Haicui Wang Holly Hardy Osama Refai Katy E S Barwick Holly H Zimmerman Joachim Weis Emma L Baple Andrew H Crosby Sebahattin Cirak C Hellmuth O Uhl M Standl J Heinrich E Thiering B Koletzko Lena Blümel Kornelius Kerl Daniel Picard Michael C Frühwald Max C Liebau Guido Reifenberger Arndt Borkhardt Martin Hasselblatt Marc Remke D Tews M Wabitsch P Fischer-Posovszky Mike-Andrew Westhoff Lisa Nonnenmacher Julia Langhans Lukas Schneele Nancy Trenkler Klaus-Michael Debatin

Mol Cell Pediatr 2017 May;4(Suppl 1)

Department of Pediatrics and Adolescent Medicine, University Medical Center Ulm, Ulm, Germany.

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http://dx.doi.org/10.1186/s40348-017-0071-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5435609PMC
May 2017

DNA methylation profiling of pediatric B-cell lymphoblastic leukemia with KMT2A rearrangement identifies hypomethylation at enhancer sites.

Pediatr Blood Cancer 2017 03 27;64(3). Epub 2016 Oct 27.

Institute of Human Genetics, Christian-Albrechts-University Kiel & University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany.

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http://dx.doi.org/10.1002/pbc.26251DOI Listing
March 2017

Atypical teratoid/rhabdoid tumor arising in a malignant glioma.

Pediatr Blood Cancer 2017 01 29;64(1):96-99. Epub 2016 Jul 29.

2nd Department of Pediatrics, Semmelweis University, Budapest, Hungary.

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http://dx.doi.org/10.1002/pbc.26173DOI Listing
January 2017

Epigenome-wide association study of body mass index, and the adverse outcomes of adiposity.

Authors:
Simone Wahl Alexander Drong Benjamin Lehne Marie Loh William R Scott Sonja Kunze Pei-Chien Tsai Janina S Ried Weihua Zhang Youwen Yang Sili Tan Giovanni Fiorito Lude Franke Simonetta Guarrera Silva Kasela Jennifer Kriebel Rebecca C Richmond Marco Adamo Uzma Afzal Mika Ala-Korpela Benedetta Albetti Ole Ammerpohl Jane F Apperley Marian Beekman Pier Alberto Bertazzi S Lucas Black Christine Blancher Marc-Jan Bonder Mario Brosch Maren Carstensen-Kirberg Anton J M de Craen Simon de Lusignan Abbas Dehghan Mohamed Elkalaawy Krista Fischer Oscar H Franco Tom R Gaunt Jochen Hampe Majid Hashemi Aaron Isaacs Andrew Jenkinson Sujeet Jha Norihiro Kato Vittorio Krogh Michael Laffan Christa Meisinger Thomas Meitinger Zuan Yu Mok Valeria Motta Hong Kiat Ng Zacharoula Nikolakopoulou Georgios Nteliopoulos Salvatore Panico Natalia Pervjakova Holger Prokisch Wolfgang Rathmann Michael Roden Federica Rota Michelle Ann Rozario Johanna K Sandling Clemens Schafmayer Katharina Schramm Reiner Siebert P Eline Slagboom Pasi Soininen Lisette Stolk Konstantin Strauch E-Shyong Tai Letizia Tarantini Barbara Thorand Ettje F Tigchelaar Rosario Tumino Andre G Uitterlinden Cornelia van Duijn Joyce B J van Meurs Paolo Vineis Ananda Rajitha Wickremasinghe Cisca Wijmenga Tsun-Po Yang Wei Yuan Alexandra Zhernakova Rachel L Batterham George Davey Smith Panos Deloukas Bastiaan T Heijmans Christian Herder Albert Hofman Cecilia M Lindgren Lili Milani Pim van der Harst Annette Peters Thomas Illig Caroline L Relton Melanie Waldenberger Marjo-Riitta Järvelin Valentina Bollati Richie Soong Tim D Spector James Scott Mark I McCarthy Paul Elliott Jordana T Bell Giuseppe Matullo Christian Gieger Jaspal S Kooner Harald Grallert John C Chambers

Nature 2017 01 21;541(7635):81-86. Epub 2016 Dec 21.

Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London W2 1PG, UK.

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http://dx.doi.org/10.1038/nature20784DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5570525PMC
January 2017

Novel IGH and MYC Translocation Partners in Diffuse Large B-Cell Lymphomas.

Genes Chromosomes Cancer 2016 12 12;55(12):932-943. Epub 2016 Jul 12.

Institute of Cell Biology (Cancer Research), University of Duisburg-Essen, Medical School, Essen, Germany.

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http://dx.doi.org/10.1002/gcc.22391DOI Listing
December 2016

Transient spontaneous remission in congenital MLL-AF10 rearranged acute myeloid leukemia presenting with cardiorespiratory failure and meconium ileus.

Mol Cell Pediatr 2016 Dec 29;3(1):30. Epub 2016 Aug 29.

Department of Pediatric Oncology, Hematology and Clinical Immunology, University Children's Hospital, Medical Faculty, Heinrich Heine University, Moorenstr. 5, 40225, Duesseldorf, Germany.

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http://dx.doi.org/10.1186/s40348-016-0061-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5002396PMC
December 2016

The t(11;14)(q13;q32)/CCND1-IGH translocation is a recurrent secondary genetic aberration in relapsed chronic lymphocytic leukemia.

Leuk Lymphoma 2016 11 25;57(11):2672-6. Epub 2016 Feb 25.

a Pathology/Cytology , F46 Karolinska University Hospital Huddinge , Stockholm , SE , Sweden ;

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http://dx.doi.org/10.3109/10428194.2016.1153085DOI Listing
November 2016

Quantitative DNA Methylation Profiling in Cancer.

Methods Mol Biol 2016 ;1381:75-92

Institute of Human Genetics, University of Kiel and University Hospital Schleswig-Holstein, Campus Kiel, Schwanenweg 24, Kiel, 24105, Germany.

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http://dx.doi.org/10.1007/978-1-4939-3204-7_5DOI Listing
October 2016

Identification of ZCCHC8 as fusion partner of ROS1 in a case of congenital glioblastoma multiforme with a t(6;12)(q21;q24.3).

Genes Chromosomes Cancer 2016 09 23;55(9):677-87. Epub 2016 Jun 23.

Cytogenetics Laboratory, Genetics Department, Garrahan Pediatrics Hospital, Buenos Aires, Argentina.

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http://dx.doi.org/10.1002/gcc.22369DOI Listing
September 2016

PLAGL1 epimutation and bladder exstrophy: Coincidence or concurrent etiology?

Birth Defects Res A Clin Mol Teratol 2016 Aug 25;106(8):724-8. Epub 2016 May 25.

Institute of Human Genetics, Christian-Albrechts-University Kiel, Kiel, Germany.

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http://dx.doi.org/10.1002/bdra.23521DOI Listing
August 2016

Downregulation of the TGFβ Pseudoreceptor BAMBI in Non-Small Cell Lung Cancer Enhances TGFβ Signaling and Invasion.

Cancer Res 2016 07 17;76(13):3785-801. Epub 2016 May 17.

Systems Biology of Signal Transduction, German Cancer Research Center, Heidelberg, Germany. BIOQUANT, University of Heidelberg, Heidelberg, Germany. Translational Lung Research Center Heidelberg (TLRC), German Center for Lung Research (DZL), Heidelberg, Germany.

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http://dx.doi.org/10.1158/0008-5472.CAN-15-1326DOI Listing
July 2016

Immunohistochemical detection of inhibitor of DNA binding 3 mutational variants in mature aggressive B-cell lymphoma.

Haematologica 2016 06 18;101(6):e259-61. Epub 2016 Mar 18.

Institute of Pathology, Hematopathology Section and Lymph Node Registry, University Hospital Schleswig-Holstein Campus Kiel, Christian-Albrechts University Kiel, Germany

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http://dx.doi.org/10.3324/haematol.2015.138701DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5013970PMC
June 2016

B-cell-specific conditional expression of Myd88p.L252P leads to the development of diffuse large B-cell lymphoma in mice.

Blood 2016 06 5;127(22):2732-41. Epub 2016 Apr 5.

Department I of Internal Medicine, University Hospital of Cologne, Cologne, Germany; Cologne Excellence Cluster on Cellular Stress Response in Aging-Associated Diseases, University of Cologne, Cologne, Germany; Center of Integrated Oncology, University Hospital of Cologne, Cologne, Germany; and Center of Molecular Medicine, University of Cologne, Cologne, Germany.

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http://dx.doi.org/10.1182/blood-2015-11-684183DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4891954PMC
June 2016

Absence of Lymphatic Vessels in PCNSL May Contribute to Confinement of Tumor Cells to the Central Nervous System.

J Neuropathol Exp Neurol 2016 06 3;75(6):499-502. Epub 2016 May 3.

From the Department of Neuropathology, University Hospital of Cologne, Cologne, Germany (MD, AB, MMR); and Institute of Human Genetics, Christian-Albrechts-University Kiel, Kiel, Germany (RS).

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http://dx.doi.org/10.1093/jnen/nlw027DOI Listing
June 2016

Genome-wide methylation analysis of retrocopy-associated CpG islands and their genomic environment.

Epigenetics 2016 03 18;11(3):216-26. Epub 2016 Feb 18.

a Institut für Humangenetik, Universitätsklinikum Essen, Universität Duisburg-Essen , Essen , Germany.

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http://dx.doi.org/10.1080/15592294.2016.1145330DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4854546PMC
March 2016

Genomic Alterations in CIITA Are Frequent in Primary Mediastinal Large B Cell Lymphoma and Are Associated with Diminished MHC Class II Expression.

Cell Rep 2015 Nov 5;13(7):1418-1431. Epub 2015 Nov 5.

Centre for Lymphoid Cancer, Department of Lymphoid Cancer Research, BC Cancer Agency, Vancouver, BC V5Z 1L3, Canada; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC V6T 2B5, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2015.10.008DOI Listing
November 2015

The differentially methylated region of MEG8 is hypermethylated in patients with Temple syndrome.

Epigenomics 2015 Oct 6;7(7):1089-97. Epub 2015 Nov 6.

Institute of Human Genetics, Christian-Albrechts-University Kiel & University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany.

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http://dx.doi.org/10.2217/epi.15.73DOI Listing
October 2015