Dr Reinaldo B Oriá, DVM, PhD - Universidade Federal do Ceará - Associate professor

Dr Reinaldo B Oriá

DVM, PhD

Universidade Federal do Ceará

Associate professor

Fortaleza, CE | Brazil

Main Specialties: Biology, Infectious Disease, Medical Microbiology, Pediatric Gastroenterology, Pediatric Infectious Diseases, Pediatrics, Pharmacology

Additional Specialties: Neurosciences

ORCID logohttps://orcid.org/0000-0002-6914-5481

Dr Reinaldo B Oriá, DVM, PhD - Universidade Federal do Ceará - Associate professor

Dr Reinaldo B Oriá

DVM, PhD

Introduction

Dr Reinaldo Oriá earned his PhD in Pharmacology by the Federal University of Ceara/Brazil with a research fellowship at the University o Virginia (2002-2004) and after his PhD (2008 and 2017). He is currently Associate Professor at the Federal University of Ceará.

Primary Affiliation: Universidade Federal do Ceará - Fortaleza, CE , Brazil

Specialties:

Additional Specialties:

Research Interests:

Education

Feb 2017 - Dec 2017
University of Virginia
Visiting resarcher
Division of Neuroscience and Center for Global Health
Jan 2008 - May 2008
University of Virginia
Research Fellow
Division of Infectious Diseases
Jul 2002 - Jul 2004
University of Virginia
Research Fellow
Division of Infectious Diseases
Dec 2004
Faculdade de Medicina da Universidade Federal do Ceara
PhD in Pharmacology
Department of Morphology

Experience

Nov 2005
Universidade Federal do Ceará
Associate professor
Department of Morphology

Publications

50Publications

1388Reads

126Profile Views

Effect of Hypoproteic and High-Fat Diets on Hippocampal Blood-Brain Barrier Permeability and Oxidative Stress.

Front Nutr 2018 9;5:131. Epub 2019 Jan 9.

Laboratory of Tissue Healing, Ontogeny and Nutrition, Department of Morphology, School of Medicine, Institute of Biomedicine, Federal University of Ceara, Fortaleza, Brazil.

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http://dx.doi.org/10.3389/fnut.2018.00131DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6333637PMC
January 2019
27 Reads

In the Heart of the Amazon: Noncommunicable Diseases and Apolipoprotein E4 Genotype in the Riverine Population.

Int J Environ Res Public Health 2018 09 7;15(9). Epub 2018 Sep 7.

Laboratório de Farmacologia Molecular, Instituto de Ciências Biológicas, Universidade Federal do Pará, Belém 66075-110, Brazil.

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http://www.mdpi.com/1660-4601/15/9/1957
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http://dx.doi.org/10.3390/ijerph15091957DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6165059PMC
September 2018
15 Reads
2.063 Impact Factor

Revisiting Inbred Mouse Models to Study the Developing Brain: The Potential Role of Intestinal Microbiota.

Front Hum Neurosci 2018 19;12:358. Epub 2018 Sep 19.

Division of Infectious Diseases and International Health, Center for Global Health, University of Virginia, Charlottesville, VA, United States.

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https://www.frontiersin.org/article/10.3389/fnhum.2018.00358
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http://dx.doi.org/10.3389/fnhum.2018.00358DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6156437PMC
September 2018
5 Reads
2.895 Impact Factor

Docosanoids Promote Neurogenesis and Angiogenesis, Blood-Brain Barrier Integrity, Penumbra Protection, and Neurobehavioral Recovery After Experimental Ischemic Stroke.

Mol Neurobiol 2018 Aug 1;55(8):7090-7106. Epub 2018 Jun 1.

Neuroscience Center of Excellence, School of Medicine, Louisiana State University Health New Orleans, 2020 Gravier St,, New Orleans, LA, 70112, USA.

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http://dx.doi.org/10.1007/s12035-018-1136-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6054805PMC
August 2018
7 Reads
5.137 Impact Factor

Modulation of Intestinal Immune and Barrier Functions by Vitamin A: Implications for Current Understanding of Malnutrition and Enteric Infections in Children.

Nutrients 2018 Aug 21;10(9). Epub 2018 Aug 21.

Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia School of Medicine, Charlottesville, VA 22908, USA.

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http://dx.doi.org/10.3390/nu10091128DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6164597PMC
August 2018
46 Reads
3.148 Impact Factor

Early Childhood Diarrhea Predicts Cognitive Delays in Later Childhood Independently of Malnutrition.

Am J Trop Med Hyg 2016 Nov 6;95(5):1004-1010. Epub 2016 Sep 6.

Center for Global Health, Division of Infectious Diseases and International Health, School of Medicine, University of Virginia, Charlottesville, Virginia.

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http://dx.doi.org/10.4269/ajtmh.16-0150DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5094207PMC
November 2016
46 Reads
2.699 Impact Factor

Prolonged maternal separation induces undernutrition and systemic inflammation with disrupted hippocampal development in mice.

Nutrition 2016 Sep 6;32(9):1019-27. Epub 2016 Mar 6.

Laboratory of the Biology of Tissue Healing, Ontogeny and Nutrition, Department of Morphology and Institute of Biomedicine, School of Medicine, Federal University of Ceara, Ceara, Brazil. Electronic address:

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http://dx.doi.org/10.1016/j.nut.2016.02.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4967409PMC
September 2016
47 Reads
2.926 Impact Factor

Early-life enteric infections: relation between chronic systemic inflammation and poor cognition in children.

Nutr Rev 2016 06 3;74(6):374-86. Epub 2016 May 3.

R.B. Oriá is with the Laboratory of Tissue Healing, Ontogeny and Nutrition, Institute of Biomedicine and Department of Morphology, Faculty of Medicine, Federal University of Ceará, Ceará, Fortaleza, Brazil. L.E. Murray-Kolb is with The Pennsylvania State University, University Park, Pennsylvania, USA. R.J. Scharf, G. Kolling, and R.L. Guerrant are with the Center for Global Health, Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia, Charlottesville, Virginia, USA. L.L. Pendergast is with the School Psychology Program, Temple University, Philadelphia, Pennsylvania, USA. D.R. Lang is with the Foundation for the National Institutes of Health, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1093/nutrit/nuw008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4892302PMC
June 2016
66 Reads
6.076 Impact Factor

Developmental aspects of the direct-developing frog Adelophryne maranguapensis.

Genesis 2016 05 2;54(5):257-71. Epub 2016 Apr 2.

Instituto de Ciências Biomédicas, Universidade Federal do Rio de Janeiro, RJ, Brazil.

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http://dx.doi.org/10.1002/dvg.22935DOI Listing
May 2016
14 Reads

Intestinal cell kinase is a novel participant in intestinal cell signaling responses to protein malnutrition.

PLoS One 2014 3;9(9):e106902. Epub 2014 Sep 3.

Department of Medicine, Center for Global Health, Digestive Research Center of Excellence, University of Virginia, Charlottesville, Virginia, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0106902PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4153720PMC
November 2015
40 Reads
3.234 Impact Factor

A global perspective on the influence of environmental exposures on the nervous system.

Nature 2015 Nov;527(7578):S187-92

Department of Morphology and Institute of Biomedicine, Faculty of Medicine, Federal University of Ceara, Fortaleza 60020, Brazil.

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http://dx.doi.org/10.1038/nature16034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4772865PMC
November 2015
15 Reads
42.351 Impact Factor

Gabapentin attenuates neuropathic pain and improves nerve myelination after chronic sciatic constriction in rats.

Neurosci Lett 2015 Oct 25;607:52-58. Epub 2015 Sep 25.

Laboratory of Tissue healing, Ontogeny and Nutrition, Department of Morphology, Faculty of Medicine, Federal University of Ceara, Fortaleza, CE, Brazil. Electronic address:

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http://dx.doi.org/10.1016/j.neulet.2015.09.021DOI Listing
October 2015
63 Reads
2.055 Impact Factor

Group a rotavirus and norovirus genotypes circulating in the northeastern Brazil in the post-monovalent vaccination era.

J Med Virol 2015 Sep 15;87(9):1480-90. Epub 2015 May 15.

Laboratory of Comparative and Environmental Virology, Oswaldo Cruz Institute- Fiocruz, Rio de Janeiro, Brazil.

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http://dx.doi.org/10.1002/jmv.24144DOI Listing
September 2015
36 Reads
2.347 Impact Factor

Glutamine and alanyl-glutamine promote crypt expansion and mTOR signaling in murine enteroids.

Am J Physiol Gastrointest Liver Physiol 2015 May 19;308(10):G831-9. Epub 2015 Mar 19.

Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, Ohio;

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http://dx.doi.org/10.1152/ajpgi.00422.2014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4437023PMC
May 2015
33 Reads
3.798 Impact Factor

Apolipoprotein E plays a key role against cryptosporidial infection in transgenic undernourished mice.

PLoS One 2014 28;9(2):e89562. Epub 2014 Feb 28.

Division of Infectious Diseases and International Medicine, Center for Global Health, School of Medicine, University of Virginia, Charlottesville, Virginia, United States of America ; Laboratory of Infectious Diseases, Clinical Research Unit, Institute of the Brazilian Semi-Arid, School of Medicine, Federal University of Ceara, Fortaleza, Ceará, Brazil.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0089562PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3938486PMC
November 2014
24 Reads
3.234 Impact Factor

Effects of glutamine alone or in combination with zinc and vitamin A on growth, intestinal barrier function, stress and satiety-related hormones in Brazilian shantytown children.

Clinics (Sao Paulo) 2014 ;69(4):225-33

Center for Global Health, Department of Physiology and Pharmacology, Clinical Research Unit & Institute of Biomedicine, School of Medicine, Federal University of Ceará, Fortaleza, CE, Brazil.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3971359PMC
http://dx.doi.org/10.6061/clinics/2014(04)02DOI Listing
November 2014
13 Reads
1.422 Impact Factor

Zinc treatment ameliorates diarrhea and intestinal inflammation in undernourished rats.

BMC Gastroenterol 2014 Aug 5;14:136. Epub 2014 Aug 5.

Laboratory of the Biology of Tissue Healing, Ontogeny and Nutrition, Department of Morphology and Institute of Biomedicine, School of Medicine, Federal University of Ceara, Rua Cel, Nunes de Melo, 1315, Fortaleza, CE, Brazil.

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http://dx.doi.org/10.1186/1471-230X-14-136DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4142448PMC
August 2014
26 Reads
2.365 Impact Factor

Infliximab attenuates inflammatory osteolysis in a model of periodontitis in Wistar rats.

Exp Biol Med (Maywood) 2014 Apr 28;239(4):442-53. Epub 2014 Feb 28.

Laboratory of the Biology of Tissue Healing, Ontogeny and Nutrition, Department of Morphology and Institute of Biomedicine, School of Medicine, Federal University of Ceara, Rua Cel. Nunes de Melo, 1315 Fortaleza, CE, Brazil.

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http://dx.doi.org/10.1177/1535370213520114DOI Listing
April 2014
46 Reads

Zinc, vitamin A, and glutamine supplementation in Brazilian shantytown children at risk for diarrhea results in sex-specific improvements in verbal learning.

Clinics (Sao Paulo) 2013 ;68(3):351-8

Department of Physiology and Pharmacology, Clinical Research Unit and Institute of Biomedicine/Center for Global Health, School of Medicine, Federal University of Ceará, Fortaleza, CE, Brazil.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3611743PMC
http://dx.doi.org/10.6061/clinics/2013(03)oa11DOI Listing
January 2014
51 Reads
1.422 Impact Factor

Oral gabapentin treatment accentuates nerve and peripheral inflammatory responses following experimental nerve constriction in Wistar rats.

Neurosci Lett 2013 Nov 16;556:93-8. Epub 2013 Oct 16.

Laboratory of Experimental Neurophysiology, Department of Physiology and Pharmacology, School of Medicine, Federal University of Ceará, Fortaleza, CE, Brazil; Laboratory of Neurophysiology, School of Veterinary, Federal and Rural University of the SemiArid, Mossoro, RN, Brazil.

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http://dx.doi.org/10.1016/j.neulet.2013.10.010DOI Listing
November 2013
36 Reads
2.055 Impact Factor

Protective mechanisms of simvastatin in experimental periodontal disease.

J Periodontol 2013 Aug 26;84(8):1145-57. Epub 2012 Nov 26.

Department of Physiology and Pharmacology, Federal University of Ceará, Fortaleza, Brazil.

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http://dx.doi.org/10.1902/jop.2012.120114DOI Listing
August 2013
22 Reads
2.706 Impact Factor

Early childhood growth failure and the developmental origins of adult disease: do enteric infections and malnutrition increase risk for the metabolic syndrome?

Nutr Rev 2012 Nov;70(11):642-53

Division of Pediatric Endocrinology, Department of Pediatrics, University of Virginia, Charlottesville, VA, USA.

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http://dx.doi.org/10.1111/j.1753-4887.2012.00543.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3493112PMC
November 2012
19 Reads
6.076 Impact Factor

Arginine decreases Cryptosporidium parvum infection in undernourished suckling mice involving nitric oxide synthase and arginase.

Nutrition 2012 Jun 20;28(6):678-85. Epub 2012 Jan 20.

Center for Global Health, Division of Infectious Diseases and International Health, School of Medicine, University of Virginia, Charlottesville, VA, USA.

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http://dx.doi.org/10.1016/j.nut.2011.09.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3351544PMC
June 2012
29 Reads
2.926 Impact Factor

Involvement of nitric oxide on the pathogenesis of irinotecan-induced intestinal mucositis: role of cytokines on inducible nitric oxide synthase activation.

Cancer Chemother Pharmacol 2012 Apr 20;69(4):931-42. Epub 2011 Nov 20.

Department of Physiology and Pharmacology, Faculty of Medicine, Federal University of Ceará, Rua Cel Nunes de Melo, 1315 Rodolfo Teófilo, Fortaleza, Ceará 60430-270, Brazil.

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http://dx.doi.org/10.1007/s00280-011-1780-zDOI Listing
April 2012
22 Reads
2.769 Impact Factor

Prolonged episodes of acute diarrhea reduce growth and increase risk of persistent diarrhea in children.

Gastroenterology 2010 Oct 2;139(4):1156-64. Epub 2010 Jun 2.

Division of Gastroenterology, Hepatology, and Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.

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http://dx.doi.org/10.1053/j.gastro.2010.05.076DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2949449PMC
October 2010
37 Reads
16.716 Impact Factor

Semantic fluency: a sensitive marker for cognitive impairment in children with heavy diarrhea burdens?

Med Hypotheses 2009 Nov 10;73(5):682-6. Epub 2009 Jun 10.

Center for Global Health, Division of Infectious Diseases and International Health, School of Medicine, University of Virginia, Charlottesville, VA, USA.

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http://dx.doi.org/10.1016/j.mehy.2009.05.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2773658PMC
November 2009
2 Reads
1.152 Impact Factor

Alanyl-glutamine and glutamine supplementation improves 5-fluorouracil-induced intestinal epithelium damage in vitro.

Dig Dis Sci 2008 Oct 6;53(10):2687-96. Epub 2008 Mar 6.

Institute of Biomedicine and Clinical Research Unit-University Hospital, Federal University of Ceará, Fortaleza, Brazil.

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http://dx.doi.org/10.1007/s10620-008-0215-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4003886PMC
October 2008
12 Reads
2.550 Impact Factor

Malnutrition as an enteric infectious disease with long-term effects on child development.

Nutr Rev 2008 Sep;66(9):487-505

Department of Medicine, University of Virginia, Charlottesville 22901, USA.

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http://dx.doi.org/10.1111/j.1753-4887.2008.00082.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2562291PMC
September 2008
25 Reads
6.076 Impact Factor

Role of retinol in protecting epithelial cell damage induced by Clostridium difficile toxin A.

Toxicon 2007 Dec 31;50(8):1027-40. Epub 2007 Jul 31.

Clinical Research Unit & Institute of Biomedicine, School of Medicine, Federal University of Ceará, Brazil.

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http://dx.doi.org/10.1016/j.toxicon.2007.07.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2268866PMC
December 2007
30 Reads
2.492 Impact Factor

Role of apolipoprotein E4 in protecting children against early childhood diarrhea outcomes and implications for later development.

Med Hypotheses 2007 13;68(5):1099-107. Epub 2006 Nov 13.

Center for Global Health, School of Medicine, University of Virginia, United States.

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http://linkinghub.elsevier.com/retrieve/pii/S030698770600698
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http://dx.doi.org/10.1016/j.mehy.2006.09.036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3993898PMC
June 2007
10 Reads
1.152 Impact Factor

Infectious diseases, balanced polymorphisms, and human evolution: a declaration of interdependence.

Curr Infect Dis Rep 2007 Mar;9(2):83-5

Center for Global Health, Division of Infectious Diseases and International Medicine, School of Medicine, University of Virginia, P.O. Box 801379, MR4, 409 Lane Road, Room 3148, Charlottesville, VA 22908, USA.

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http://dx.doi.org/10.1007/s11908-007-0001-8DOI Listing
March 2007
3 Reads

Apolipoprotein E knockout mice have accentuated malnutrition with mucosal disruption and blunted insulin-like growth factor I responses to refeeding.

Nutr Res 2006 Aug;26(8):427-435

Center for Global Health, Division of Infectious Diseases and International Health, University of Virginia, Charlottesville, VA 22908-1379, USA ; Department of Morphology, Federal University of Ceará, Fortaleza, CE 60430-270, Brazil.

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http://dx.doi.org/10.1016/j.nutres.2006.06.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4157828PMC
August 2006
46 Reads
2.585 Impact Factor

Caspase and bid involvement in Clostridium difficile toxin A-induced apoptosis and modulation of toxin A effects by glutamine and alanyl-glutamine in vivo and in vitro.

Infect Immun 2006 Jan;74(1):81-7

Center for Global Health, Division of Infectious Diseases and International Health, University of Virginia, MR4, Lane Road, Room 3148, Charlottesville, VA 22908, USA.

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http://dx.doi.org/10.1128/IAI.74.1.81-87.2006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1346681PMC
January 2006
9 Reads
3.731 Impact Factor

Clostridium difficile toxin A induces intestinal epithelial cell apoptosis and damage: role of Gln and Ala-Gln in toxin A effects.

Dig Dis Sci 2005 Jul;50(7):1271-8

Center for Global Health, Department of Intemal Medicine, School of Medicine, University of Virginia, Charlottesville, Virginia, USA.

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http://dx.doi.org/10.1007/s10620-005-2771-xDOI Listing
July 2005
14 Reads
2.550 Impact Factor

Limitations in verbal fluency following heavy burdens of early childhood diarrhea in Brazilian shantytown children.

Child Neuropsychol 2005 Jun;11(3):233-44

Kluge Children's Rehabilitation Center, Division of Neuropsychology, University of Virginia, USA.

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http://dx.doi.org/10.1080/092970490911252DOI Listing
June 2005
27 Reads
2.181 Impact Factor

APOE4 protects the cognitive development in children with heavy diarrhea burdens in Northeast Brazil.

Pediatr Res 2005 Feb 20;57(2):310-6. Epub 2004 Dec 20.

Center for Global Health, School of Medicine, Kluge's Children Rehabilitation Center, University of Virginia, Charlottesville, VA 22908, USA.

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http://dx.doi.org/10.1203/01.PDR.0000148719.82468.CADOI Listing
February 2005
12 Reads
2.314 Impact Factor

Alanyl-glutamine hastens morphologic recovery from 5-fluorouracil-induced mucositis in mice.

Nutrition 2004 Oct;20(10):934-41

Department of Morphology, Institute of Biomedicine and Clinical Research Unit-University Hospital, Federal University of Ceará, Brazil.

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http://dx.doi.org/10.1016/j.nut.2004.06.016DOI Listing
October 2004
5 Reads
2.926 Impact Factor

Top co-authors

Richard L Guerrant
Richard L Guerrant

University of Virginia

36
Sean R Moore
Sean R Moore

Cincinnati Children's Hospital Medical Center

8
Peter D Patrick
Peter D Patrick

University of Virginia

7
Relana C Pinkerton
Relana C Pinkerton

University of Virginia

6
Cirle A Warren
Cirle A Warren

University of Virginia

6
Ronaldo A Ribeiro
Ronaldo A Ribeiro

Federal University of Ceará

6
Mariana L Vale
Mariana L Vale

Federal University of Ceará

5
David T Bolick
David T Bolick

University of Virginia

5