Reinald Pamplona

Reinald Pamplona

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Reinald Pamplona

Publications by authors named "Reinald Pamplona"

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Deficient Endoplasmic Reticulum-Mitochondrial Phosphatidylserine Transfer Causes Liver Disease.

Cell 2019 May;177(4):881-895.e17

Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology, Barcelona, Spain; Departament de Bioquímica i Biomedicina Molecular, Facultat de Biología, Barcelona, Spain; CIBER de Diabetes y Enfermedades Metabólicas Asociadas (CIBERDEM), Instituto de Salud Carlos III, Madrid, Spain. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00928674193039
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http://dx.doi.org/10.1016/j.cell.2019.04.010DOI Listing
May 2019

Mediterranean diet, physical activity and subcutaneous advanced glycation end-products' accumulation: a cross-sectional analysis in the ILERVAS project.

Eur J Nutr 2019 May 7. Epub 2019 May 7.

Endocrinology and Nutrition Department, University Hospital Arnau de Vilanova, Obesity, Diabetes and Metabolism (ODIM) Research Group, IRBLleida, University of Lleida, Avda. Rovira Roure 80, 25198, Lleida, Catalonia, Spain.

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http://dx.doi.org/10.1007/s00394-019-01983-wDOI Listing
May 2019

Biomarker Identification, Safety, and Efficacy of High-Dose Antioxidants for Adrenomyeloneuropathy: a Phase II Pilot Study.

Neurotherapeutics 2019 May 10. Epub 2019 May 10.

Neurometabolic Diseases Laboratory, Bellvitge Biomedical Research Institute, Hospital Duran i Reynals, Gran Via de l'Hospitalet 199, 08908, L'Hospitalet de Llobregat, Barcelona, Spain.

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http://dx.doi.org/10.1007/s13311-019-00735-2DOI Listing
May 2019

Location-dependent effects of trauma on oxidative stress in humans.

PLoS One 2018 11;13(10):e0205519. Epub 2018 Oct 11.

Department of Critical Care Unit, University Hospital Arnau de Vilanova, University of Lleida-IRBLleida, Lleida, Spain.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0205519PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6181391PMC
April 2019

Lung function measurements in the prediabetes stage: data from the ILERVAS Project.

Acta Diabetol 2019 Apr 15. Epub 2019 Apr 15.

Endocrinology and Nutrition Department, Hospital Universitari Vall d'Hebron, Diabetes and Metabolism Research Unit, Vall d'Hebron Institut de Recerca (VHIR), Universitat Autònoma de Barcelona, Barcelona, Catalonia, Spain.

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http://link.springer.com/10.1007/s00592-019-01333-6
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http://dx.doi.org/10.1007/s00592-019-01333-6DOI Listing
April 2019

Redox lipidomics to better understand brain aging and function.

Free Radic Biol Med 2019 Mar 18. Epub 2019 Mar 18.

Freshage Research Group-Department of Physiology, Faculty of Medicine, University of Valencia, CIBERFES, INCLIVA, Spain.

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http://dx.doi.org/10.1016/j.freeradbiomed.2019.03.016DOI Listing
March 2019

Effects of Mediterranean Diet and Physical Activity on Pulmonary Function: A Cross-Sectional Analysis in the ILERVAS Project.

Nutrients 2019 Feb 3;11(2). Epub 2019 Feb 3.

Endocrinology and Nutrition Department, University Hospital Arnau de Vilanova, Obesity, Diabetes and Metabolism (ODIM) research group, IRBLleida, University of Lleida, 25195 Lleida, Spain.

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http://dx.doi.org/10.3390/nu11020329DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6413220PMC
February 2019

The cirrhotic liver is depleted of docosahexaenoic acid (DHA), a key modulator of NF-κB and TGFβ pathways in hepatic stellate cells.

Cell Death Dis 2019 Jan 8;10(1):14. Epub 2019 Jan 8.

Department of Gene Therapy and Hepatology, Center for Applied Medical Research (CIMA), University of Navarra (UNAV), Pamplona, Spain.

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http://www.nature.com/articles/s41419-018-1243-0
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http://dx.doi.org/10.1038/s41419-018-1243-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6325107PMC
January 2019

Lipids and lipoxidation in human brain aging. Mitochondrial ATP-synthase as a key lipoxidation target.

Redox Biol 2018 Dec 19:101082. Epub 2018 Dec 19.

Department of Experimental Medicine, University of Lleida-Institute for Research in Biomedicine of Lleida (UdL-IRBLleida), Lleida, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.redox.2018.101082DOI Listing
December 2018

Regional vulnerability to lipoxidative damage and inflammation in normal human brain aging.

Exp Gerontol 2018 10 2;111:218-228. Epub 2018 Aug 2.

Institute of Neuropathology, Bellvitge University Hospital, Biomedical Research Institute of Bellvitge (IDIBELL), Hospitalet de Llobregat, Spain; Department of Pathology and Experimental Therapeutics, University of Barcelona, Hospitalet de Llobregat, Spain; Biomedical Research Network Center on Neurodegenerative Diseases (CIBERNED), Institute Carlos III, Spanish Ministry of Science and Innovation, Madrid, Spain; Institute of Neurosciences, University of Barcelona, Hospitalet de Llobregat, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.exger.2018.07.023DOI Listing
October 2018

Lipidomics Reveals a Tissue-Specific Fingerprint.

Front Physiol 2018 28;9:1165. Epub 2018 Aug 28.

Department of Experimental Medicine, Institute for Research in Biomedicine of Lleida, University of Lleida, Lleida, Spain.

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http://dx.doi.org/10.3389/fphys.2018.01165DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6121266PMC
August 2018

[De novo biosynthesis of glycerophospholipids and longevity].

Rev Esp Geriatr Gerontol 2019 Mar - Apr;54(2):88-93. Epub 2018 Jul 4.

Departament de Medicina Experimental, Universitat de Lleida-Institut de Recerca Biomèdica de Lleida (UdL-IRBLleida), Lleida, España. Electronic address:

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http://dx.doi.org/10.1016/j.regg.2018.05.006DOI Listing
July 2018

Essential physiological differences characterise short- and long-lived strains of Drosophila melanogaster.

J Gerontol A Biol Sci Med Sci 2018 Jun 26. Epub 2018 Jun 26.

Institute for Cell and Molecular Biosciences, Newcastle University Institute for Ageing, Newcastle University, Newcastle upon Tyne, United Kingdom.

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http://dx.doi.org/10.1093/gerona/gly143DOI Listing
June 2018

Lipid Profile in Human Frontal Cortex Is Sustained Throughout Healthy Adult Life Span to Decay at Advanced Ages.

J Gerontol A Biol Sci Med Sci 2018 05;73(6):703-710

Department of Experimental Medicine, University of Lleida-Institute for Research in Biomedicine of Lleida (UdL-IRBLleida), Spain.

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http://dx.doi.org/10.1093/gerona/glx164DOI Listing
May 2018

Lipidomics reveals altered biosynthetic pathways of glycerophospholipids and cell signaling as biomarkers of the polycystic ovary syndrome.

Oncotarget 2018 Jan 17;9(4):4522-4536. Epub 2017 Dec 17.

Department of Experimental Medicine, Lleida University-Institute for Research in Biomedicine of Lleida (UdL-IRBLleida), 25198 Lleida, Spain.

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http://dx.doi.org/10.18632/oncotarget.23393DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5796992PMC
January 2018

Region-specific vulnerability to lipid peroxidation and evidence of neuronal mechanisms for polyunsaturated fatty acid biosynthesis in the healthy adult human central nervous system.

Biochim Biophys Acta Mol Cell Biol Lipids 2017 May 7;1862(5):485-495. Epub 2017 Feb 7.

Department of Experimental Medicine, University of Lleida-Institute for Research in Biomedicine of Lleida (UdL-IRBLleida), E-25198 Lleida, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.bbalip.2017.02.001DOI Listing
May 2017

Sixty years old is the breakpoint of human frontal cortex aging.

Free Radic Biol Med 2017 02 13;103:14-22. Epub 2016 Dec 13.

Department of Experimental Medicine, University of Lleida-Institute for Research in Biomedicine of Lleida (UdL-IRBLleida), E-25198 Lleida, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.freeradbiomed.2016.12.010DOI Listing
February 2017

Adipocyte lipopolysaccharide binding protein (LBP) is linked to a specific lipidomic signature.

Obesity (Silver Spring) 2017 02 21;25(2):391-400. Epub 2016 Dec 21.

Department of Diabetes, Endocrinology and Nutrition, Institut d'Investigació Biomèdica de Girona (IdIBGi), CIBEROBN (CB06/03/010) and Instituto de Salud Carlos III (ISCIII), Girona, Spain.

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http://dx.doi.org/10.1002/oby.21711DOI Listing
February 2017

A Stress-Resistant Lipidomic Signature Confers Extreme Longevity to Humans.

J Gerontol A Biol Sci Med Sci 2017 01 24;72(1):30-37. Epub 2016 Mar 24.

Department of Experimental Medicine, University of Lleida-Biomedical Research Institute of Lleida (UdL-IRBLleida), Spain.

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http://dx.doi.org/10.1093/gerona/glw048DOI Listing
January 2017

Metabolomics Predicts Neuroimaging Characteristics of Transient Ischemic Attack Patients.

EBioMedicine 2016 Dec 9;14:131-138. Epub 2016 Nov 9.

NUTREN-Nutrigenomics Center, Department of Experimental Medicine, Parc Científic i Tecnològic Agroalimentari de Lleida-Universitat de Lleida-IRBLLEIDA, Lleida, Spain.

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http://dx.doi.org/10.1016/j.ebiom.2016.11.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5161417PMC
December 2016

Target of rapamycin activation predicts lifespan in fruit flies.

Cell Cycle 2015 ;14(18):2949-58

a Institute for Cell and Molecular Biosciences; Newcastle University Institute for Ageing; Newcastle University ; Newcastle-Upon-Tyne , UK.

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https://www.tandfonline.com/doi/full/10.1080/15384101.2015.1
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http://dx.doi.org/10.1080/15384101.2015.1071745DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4630862PMC
August 2016

Metabotyping human endometrioid endometrial adenocarcinoma reveals an implication of endocannabinoid metabolism.

Oncotarget 2016 Aug;7(32):52364-52374

Department of Pathology and Molecular Genetics/Oncologic Pathology Group, Hospital Universitari Arnau de Vilanova, Universitat de Lleida, IRBLleida, E-25198, Lleida, Spain.

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http://dx.doi.org/10.18632/oncotarget.10564DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5239558PMC
August 2016

Lipidomics of human brain aging and Alzheimer's disease pathology.

Int Rev Neurobiol 2015 19;122:133-89. Epub 2015 Jun 19.

Department of Experimental Medicine, University of Lleida-Biomedical Research Institute of Lleida, Lleida, Spain. Electronic address:

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http://dx.doi.org/10.1016/bs.irn.2015.05.008DOI Listing
June 2016

Redox proteomic profiling of neuroketal-adducted proteins in human brain: Regional vulnerability at middle age increases in the elderly.

Free Radic Biol Med 2016 06 8;95:1-15. Epub 2016 Mar 8.

Institute of Neuropathology, University Hospital of Bellvitge, IDIBELL (Biomedical Research Institute of Bellvitge), Carrer Feixa Llarga sn, 08907 Hospitalet de Llobregat, Spain; Department of Pathology and Experimental Therapeutics, University of Barcelona, Carrer Feixa Llarga sn, 08907 Hospitalet de Llobregat, Spain; CIBERNED (Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas), Spain. Electronic address:

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http://dx.doi.org/10.1016/j.freeradbiomed.2016.02.034DOI Listing
June 2016

Human Aging Is a Metabolome-related Matter of Gender.

J Gerontol A Biol Sci Med Sci 2016 May 26;71(5):578-85. Epub 2015 May 26.

Department of Experimental Medicine, University of Lleida-Biomedical Research Institute of Lleida (IRBLleida), Spain.

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http://dx.doi.org/10.1093/gerona/glv074DOI Listing
May 2016

Oral intake of genetically engineered high-carotenoid corn ameliorates hepatomegaly and hepatic steatosis in PTEN haploinsufficient mice.

Biochim Biophys Acta 2016 04 26;1862(4):526-535. Epub 2016 Jan 26.

Department of Experimental Medicine, Faculty of Medicine, University of Lleida-IRBLleida, Av. Rovira Roure 80, 25198 Lleida, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.bbadis.2016.01.018DOI Listing
April 2016

Metabolomics uncovers the role of adipose tissue PDXK in adipogenesis and systemic insulin sensitivity.

Diabetologia 2016 Apr 2;59(4):822-32. Epub 2016 Feb 2.

Department of Diabetes, Endocrinology and Nutrition, Institut d'Investigació Biomèdica de Girona (IdIBGi), Hospital of Girona 'Dr Josep Trueta', Carretera de França s/n, 17007, Girona, Spain.

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http://dx.doi.org/10.1007/s00125-016-3863-1DOI Listing
April 2016

Early and gender-specific differences in spinal cord mitochondrial function and oxidative stress markers in a mouse model of ALS.

Acta Neuropathol Commun 2016 Jan 13;4. Epub 2016 Jan 13.

The Metabolic Pathophysiology Research Group, Deparment Experimental Medicine, University of Lleida-Institute for Research in Biomedicine of Lleida (UdL- IRBLleida), Avda Rovira Roure, 80, E-25198, Lleida, Spain.

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http://dx.doi.org/10.1186/s40478-015-0271-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4711180PMC
January 2016

Altered glycolipid and glycerophospholipid signaling drive inflammatory cascades in adrenomyeloneuropathy.

Hum Mol Genet 2015 Dec 14;24(24):6861-76. Epub 2015 Sep 14.

Neurometabolic Diseases Laboratory, Bellvitge Biomedical Research Institute (IDIBELL), 08908 L'Hospitalet de Llobregat, Barcelona, Spain, Institute of Neuropathology, University of Barcelona, 08908 L'Hospitalet de Llobregat, Barcelona, Spain, Center for Biomedical Research on Rare Diseases (CIBERER), Catalan Institution of Research and Advanced Studies (ICREA), Barcelona, Spain

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http://hmg.oxfordjournals.org/content/early/2015/10/20/hmg.d
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http://www.hmg.oxfordjournals.org/lookup/doi/10.1093/hmg/ddv
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http://dx.doi.org/10.1093/hmg/ddv375DOI Listing
December 2015

Voltage-gated calcium channel blockers deregulate macroautophagy in cardiomyocytes.

Int J Biochem Cell Biol 2015 Nov 30;68:166-75. Epub 2015 Sep 30.

Universitat de Lleida, Institut de Recerca Biomèdica de Lleida (IRBLleida), Spain. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S13572725153002
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http://dx.doi.org/10.1016/j.biocel.2015.09.010DOI Listing
November 2015

Long lifespans have evolved with long and monounsaturated fatty acids in birds.

Evolution 2015 Oct 24;69(10):2776-84. Epub 2015 Sep 24.

Departamento de Medicina Experimental, Universidad de Lleida - Instituto de Investigación Biomédica de Lleida (IRBLleida), 25198, Lleida, Spain.

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http://doi.wiley.com/10.1111/evo.12754
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http://dx.doi.org/10.1111/evo.12754DOI Listing
October 2015

Neuroinflammatory Gene Regulation, Mitochondrial Function, Oxidative Stress, and Brain Lipid Modifications With Disease Progression in Tau P301S Transgenic Mice as a Model of Frontotemporal Lobar Degeneration-Tau.

J Neuropathol Exp Neurol 2015 Oct;74(10):975-99

From the Institut de Neuropatologia, IDIBELL-Hospital Universitari de Bellvitge (ILG, EA, MC, MAU, RB, IF); and Universitat de Barcelona (IF), Hospitalet de Llobregat, Barcelona; and CIBERNED (Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas) (IF); and Department of Experimental Medicine, University of Lleida-Biomedical Research Institute of Lleida (AN, RC, MPO, RP), Lleida, Spain.

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http://jnen.oxfordjournals.org/content/jnen/74/10/975.full.p
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http://jnen.oxfordjournals.org/cgi/doi/10.1097/NEN.000000000
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http://dx.doi.org/10.1097/NEN.0000000000000241DOI Listing
October 2015

Obesity changes the human gut mycobiome.

Sci Rep 2015 Oct 12;5:14600. Epub 2015 Oct 12.

Department of Diabetes, Endocrinology and Nutrition, Institut d'Investigacio´ Biomèdica de Girona (IdIBGi), CIBEROBN (CB06/03/010) and Instituto de Salud Carlos III (ISCIII), Girona, Spain.

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http://www.nature.com/articles/srep14600
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http://dx.doi.org/10.1038/srep14600DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4600977PMC
October 2015

Nutridynamics: mechanism(s) of action of bioactive compounds and their effects.

Int J Food Sci Nutr 2015 Jul;66 Suppl 1:S22-30

Departament de Medicina Experimental, NUTREN-Nutrigenomics, Metabolic Pathophysiology Research Group, PCiTAL-IRBLleida-Universitat de Lleida , Spain.

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July 2015

Muscle mitohormesis promotes cellular survival via serine/glycine pathway flux.

FASEB J 2015 Apr 9;29(4):1314-28. Epub 2014 Dec 9.

*German Institute of Human Nutrition, Potsdam-Rehbruecke, Germany; Human and Animal Physiology, Wageningen University, Wageningen, The Netherlands; and Biomedical Research Institute, University of Lleida, Lleida, Spain

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http://www.fasebj.org/doi/10.1096/fj.14-261503
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http://dx.doi.org/10.1096/fj.14-261503DOI Listing
April 2015

Neuroinflammatory signals in Alzheimer disease and APP/PS1 transgenic mice: correlations with plaques, tangles, and oligomeric species.

J Neuropathol Exp Neurol 2015 Apr;74(4):319-44

From the Institut de Neuropatologia, Institut d'Investigació Biomèdica de Bellvitge-Hospital Universitari de Bellvitge (IL-G, EA, PG-E, BA, FL, MC, JM, AP, IF); Universitat de Barcelona (IF); and Neurometabolic Diseases Laboratory, Institut d'Investigació Biomèdica de Bellvitge (AS, AP), Hospitalet de Llobregat; Catalan Institution for Research and Advanced Studies (AP), Barcelona; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (IF) and Center for Biomedical Research on Rare Diseases (AS, AP), Madrid; and Department of Experimental Medicine, University of Lleida-Biomedical Research Institute of Lleida, Lleida (MP-O, RP), Spain; and Section Neuroscience, Department of Psychology, Sapienza University of Rome (AF); and European Center for Brain Research/IRCCS Santa Lucia Foundation (AF), Rome, Italy.

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http://dx.doi.org/10.1097/NEN.0000000000000176DOI Listing
April 2015

Deregulation of purine metabolism in Alzheimer's disease.

Neurobiol Aging 2015 Jan 8;36(1):68-80. Epub 2014 Aug 8.

Institute of Neuropathology, Bellvitge University Hospital-Bellvitge Biomedical Research Institute (IDIBELL), L'Hospitalet de Llobregat, Spain; University of Barcelona, Bellvitge Campus, L'Hospitalet de Llobregat, Spain; Centre for Networked Biomedical Research in Neurodegenerative Diseases (CIBERNED), Institute Carlos III, Madrid, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.neurobiolaging.2014.08.004DOI Listing
January 2015

Metabolomics predicts stroke recurrence after transient ischemic attack.

Neurology 2015 Jan 3;84(1):36-45. Epub 2014 Dec 3.

From NUTREN-Nutrigenomics Center (M.J., M.P.-O.), Department of Experimental Medicine (R.P.), Parc Científic i Tecnològic Agroalimentari de Lleida-Universitat de Lleida-IRBLleida, Lleida; Stroke Unit (G.M.-C., I.S., S.C., J.S., A.Q., I.B., F.P.), Department of Neurology, Universitat de Lleida, Hospital Universitari Arnau de Vilanova de Lleida, IRBLleida; and Laboratori Clinic (J.F.), Universitari Arnau de Vilanova de Lleida, IRBLleida, Spain.

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http://dx.doi.org/10.1212/WNL.0000000000001093DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4336096PMC
January 2015

Plasma lipidomics discloses metabolic syndrome with a specific HDL phenotype.

FASEB J 2014 Dec 28;28(12):5163-71. Epub 2014 Aug 28.

Department of Experimental Medicine, University of Lleida-Biomedical Research Institute of Lleida, Lleida, Spain;

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http://www.fasebj.org/doi/10.1096/fj.14-253187
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http://dx.doi.org/10.1096/fj.14-253187DOI Listing
December 2014

[A study of selective neuronal vulnerability in the human central nervous system].

Rev Esp Geriatr Gerontol 2013 Sep-Oct;48(5):216-23. Epub 2013 Sep 5.

Departament de Medicina Experimental, Universitat de Lleida-IRBLleida, Lleida, Catalunya, España. Electronic address:

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http://dx.doi.org/10.1016/j.regg.2013.04.005DOI Listing
October 2014

Caloric restriction reveals a metabolomic and lipidomic signature in liver of male mice.

Aging Cell 2014 Oct 23;13(5):828-37. Epub 2014 Jul 23.

Department of Experimental Medicine, University of Lleida-Biomedical Research Institute of Lleida, Lleida, 25198, Spain.

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http://dx.doi.org/10.1111/acel.12241DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4331741PMC
October 2014

A salmon peptide diet alleviates experimental colitis as compared with fish oil.

J Nutr Sci 2013 10;2:e2. Epub 2013 Jan 10.

Institute of Medicine, University of Bergen , Bergen , Norway ; Division of Gastroenterology, Department of Medicine , Haukeland University Hospital , Bergen , Norway.

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http://dx.doi.org/10.1017/jns.2012.23DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4153328PMC
September 2014

Hydroxytyrosol ameliorates oxidative stress and mitochondrial dysfunction in doxorubicin-induced cardiotoxicity in rats with breast cancer.

Biochem Pharmacol 2014 Jul 12;90(1):25-33. Epub 2014 Apr 12.

Department of Biochemistry and Molecular Biology II, Biomedical Research Center, Granada, Spain; "José Mataix" Institute of Nutrition and Food Technology, Biomedical Research Center, Granada, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.bcp.2014.04.001DOI Listing
July 2014

Metabolomics of human brain aging and age-related neurodegenerative diseases.

J Neuropathol Exp Neurol 2014 Jul;73(7):640-57

From the Department of Experimental Medicine, University of Lleida-Biomedical Research Institute of Lleida, Lleida (MJ, MP-O, AN, RP); Institute of Neuropathology, Bellvitge University Hospital, University of Barcelona, Biomedical Research Institute of Bellvitge, L'Hospitalet de Llobregat, Barcelona (IF); and Center for Biomedical Research on Neurodegenerative Diseases, Spanish Institute for Health Carlos III, Madrid (IF), Spain.

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https://academic.oup.com/jnen/article-lookup/doi/10.1097/NEN
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http://dx.doi.org/10.1097/NEN.0000000000000091DOI Listing
July 2014

Independent and additive effects of atenolol and methionine restriction on lowering rat heart mitochondria oxidative stress.

J Bioenerg Biomembr 2014 Jun 8;46(3):159-72. Epub 2013 Dec 8.

Department of Animal Physiology-II, Faculty of Biological Sciences, Complutense University of Madrid (UCM), Madrid, Spain.

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http://dx.doi.org/10.1007/s10863-013-9535-7DOI Listing
June 2014

Human omental and subcutaneous adipose tissue exhibit specific lipidomic signatures.

FASEB J 2014 Mar 21;28(3):1071-81. Epub 2013 Nov 21.

1Section of Diabetes, Endocrinology and Nutrition, Hospital of Girona "Dr Josep Trueta," Carretera de França s/n, 17007, Girona, Spain.

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http://dx.doi.org/10.1096/fj.13-234419DOI Listing
March 2014

Membrane lipid unsaturation as physiological adaptation to animal longevity.

Front Physiol 2013 Dec 17;4:372. Epub 2013 Dec 17.

Department of Experimental Medicine, University of Lleida-Biomedical Research Institute of Lleida (UdL-IRBLleida) Lleida, Spain.

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http://journal.frontiersin.org/article/10.3389/fphys.2013.00
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http://dx.doi.org/10.3389/fphys.2013.00372DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3865700PMC
December 2013

Plasma long-chain free fatty acids predict mammalian longevity.

Sci Rep 2013 Nov 28;3:3346. Epub 2013 Nov 28.

Department of Experimental Medicine, University of Lleida-Biomedical Research Institute of Lleida (IRBLleida), E-25198 Lleida, Spain.

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http://dx.doi.org/10.1038/srep03346DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3842621PMC
November 2013

Exceptionally old mice are highly resistant to lipoxidation-derived molecular damage.

Age (Dordr) 2013 Jun 25;35(3):621-35. Epub 2012 Feb 25.

Department of Physiology (Animal Physiology II), Faculty of Biological Sciences, Complutense University of Madrid, Madrid, 28040, Spain.

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http://dx.doi.org/10.1007/s11357-012-9391-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3636393PMC
June 2013

Specific lipidome signatures in central nervous system from methionine-restricted mice.

J Proteome Res 2013 Jun 30;12(6):2679-89. Epub 2013 Apr 30.

Department of Experimental Medicine, Faculty of Medicine, University of Lleida -IRBLleida, Lleida, Spain.

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http://dx.doi.org/10.1021/pr400064aDOI Listing
June 2013

Lipidomic and metabolomic analyses reveal potential plasma biomarkers of early atheromatous plaque formation in hamsters.

Cardiovasc Res 2013 Mar 12;97(4):642-52. Epub 2012 Dec 12.

Department of Experimental Medicine, Faculty of Medicine, Universitat de Lleida-IRBLleida, Spain.

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http://dx.doi.org/10.1093/cvr/cvs368DOI Listing
March 2013

Formation of S-(carboxymethyl)-cysteine in rat liver mitochondrial proteins: effects of caloric and methionine restriction.

Amino Acids 2013 Feb 22;44(2):361-71. Epub 2012 Jun 22.

Department of Experimental Medicine, Faculty of Medicine, University of Lleida-IRBLleida, Street Montserrat Roig-2, 25008 Lleida, Spain.

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http://link.springer.com/10.1007/s00726-012-1339-2
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February 2013

Non-enzymatic modification of aminophospholipids by carbonyl-amine reactions.

Int J Mol Sci 2013 Feb 5;14(2):3285-313. Epub 2013 Feb 5.

Department of Experimental Medicine, Faculty of Medicine, University of Lleida-Biomedical Research Institute of Lleida (UdL-IRBLleida), Lleida E25198, Catalonia, Spain.

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http://www.mdpi.com/1422-0067/14/2/3285
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http://dx.doi.org/10.3390/ijms14023285DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3588044PMC
February 2013

dj-1β regulates oxidative stress, insulin-like signaling and development in Drosophila melanogaster.

Cell Cycle 2012 Oct 14;11(20):3876-86. Epub 2012 Sep 14.

Institute of Biomedical Technology and Tampere University Hospital, University of Tampere, Tampere, Finland.

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https://www.tandfonline.com/doi/full/10.4161/cc.22073
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http://dx.doi.org/10.4161/cc.22073DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3495829PMC
October 2012

Amyloid generation and dysfunctional immunoproteasome activation with disease progression in animal model of familial Alzheimer's disease.

Brain Pathol 2012 Sep 13;22(5):636-53. Epub 2012 Jan 13.

Institut de Neuropatologia, IDIBELL-Hospital Universitari de Bellvitge, Universitat de Barcelona, Hospitalet de Llobregat; Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Barcelona, Spain.

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http://dx.doi.org/10.1111/j.1750-3639.2011.00560.xDOI Listing
September 2012

Effects of aging and methionine restriction applied at old age on ROS generation and oxidative damage in rat liver mitochondria.

Biogerontology 2012 Aug 13;13(4):399-411. Epub 2012 May 13.

Department of Animal Physiology-II, Faculty of Biological Sciences, Complutense University of Madrid (UCM), c/Jose Antonio Novais 2, Madrid, Spain.

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http://link.springer.com/10.1007/s10522-012-9384-5
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August 2012

Cellular dysfunction in diabetes as maladaptive response to mitochondrial oxidative stress.

Exp Diabetes Res 2012 2;2012:696215. Epub 2012 Jan 2.

Department of Experimental Medicine, Faculty of Medicine, University of Lleida-IRBLleida, Spain.

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http://dx.doi.org/10.1155/2012/696215DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3255456PMC
May 2012

Dietary supplementation of krill oil attenuates inflammation and oxidative stress in experimental ulcerative colitis in rats.

Scand J Gastroenterol 2012 Jan 30;47(1):49-58. Epub 2011 Nov 30.

Department of Medicine, Division of Gastroenterology, Stavanger University Hospital, Stavanger, Norway.

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http://dx.doi.org/10.3109/00365521.2011.634025DOI Listing
January 2012

Forty percent methionine restriction lowers DNA methylation, complex I ROS generation, and oxidative damage to mtDNA and mitochondrial proteins in rat heart.

J Bioenerg Biomembr 2011 Dec 18;43(6):699-708. Epub 2011 Oct 18.

Department of Animal Physiology-II, Faculty of Biological Sciences, Complutense University of Madrid (UCM), Madrid, Spain.

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http://dx.doi.org/10.1007/s10863-011-9389-9DOI Listing
December 2011

Mitochondria and aging.

J Aging Res 2011 25;2011:782946. Epub 2011 Jul 25.

Division of Biology of Aging, Department of Aging and Geriatric Research, College of Medicine, Institute on Aging, University of Florida, Gainesville, FL 32611, USA.

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http://www.hindawi.com/journals/jar/2011/782946/
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3144711PMC
November 2011

An evolutionary comparative scan for longevity-related oxidative stress resistance mechanisms in homeotherms.

Biogerontology 2011 Oct 14;12(5):409-35. Epub 2011 Jul 14.

Department of Experimental Medicine, University of Lleida-IRBLleida, Lleida, 25008, Spain.

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http://link.springer.com/10.1007/s10522-011-9348-1
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October 2011

Molecular and structural antioxidant defenses against oxidative stress in animals.

Am J Physiol Regul Integr Comp Physiol 2011 Oct 20;301(4):R843-63. Epub 2011 Jul 20.

Department of Experimental Medicine, University of Lleida Biomedical Research Institute of Lleida, Lleida, Spain.

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http://www.physiology.org/doi/10.1152/ajpregu.00034.2011
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October 2011

Cell stress induces TDP-43 pathological changes associated with ERK1/2 dysfunction: implications in ALS.

Acta Neuropathol 2011 Sep 25;122(3):259-70. Epub 2011 Jun 25.

Grup de Fisiopatologia Metabòlica, Departament de Medicina Experimental, Universitat de Lleida-IRBLleida, Lleida, Spain.

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http://dx.doi.org/10.1007/s00401-011-0850-yDOI Listing
September 2011

Multicompartmental LC-Q-TOF-based metabonomics as an exploratory tool to identify novel pathways affected by polyphenol-rich diets in mice.

J Proteome Res 2011 Aug 17;10(8):3501-12. Epub 2011 Jun 17.

Institut de Recerca Biomèdica de Lleida-Universitat de Lleida-Parc Científic i Agroalimentari Tecnològic de Lleida (IRBLLEIDA-UdL-PCiTAL), c/Montserrat Roig 2, 25008 Lleida, Spain.

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http://dx.doi.org/10.1021/pr200132sDOI Listing
August 2011

Advanced lipoxidation end-products.

Authors:
Reinald Pamplona

Chem Biol Interact 2011 Jun 14;192(1-2):14-20. Epub 2011 Jan 14.

Department of Experimental Medicine, Faculty of Medicine, University of Lleida-IRBLleida, c/Montserrat Roig-2, E-25008 Lleida, Spain.

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http://dx.doi.org/10.1016/j.cbi.2011.01.007DOI Listing
June 2011

Mitochondrial dysfunction and oxidative and endoplasmic reticulum stress in argyrophilic grain disease.

J Neuropathol Exp Neurol 2011 Apr;70(4):253-63

Department of Experimental Medicine, University of Lleida-Irblleida, Lleida, Spain.

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http://dx.doi.org/10.1097/NEN.0b013e31820f8765DOI Listing
April 2011

Stanozolol treatment decreases the mitochondrial ROS generation and oxidative stress induced by acute exercise in rat skeletal muscle.

J Appl Physiol (1985) 2011 Mar 16;110(3):661-9. Epub 2010 Dec 16.

Departamento de Bioquímica y Biología Molecular I, Facultad de Biología, C/José Antonio Novais-2, Universidad Complutense, 28040 Madrid, Spain.

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http://dx.doi.org/10.1152/japplphysiol.00790.2010DOI Listing
March 2011

Mitochondrial DNA damage and animal longevity: insights from comparative studies.

Authors:
Reinald Pamplona

J Aging Res 2011 Mar 2;2011:807108. Epub 2011 Mar 2.

Department of Experimental Medicine, Faculty of Medicine, University of Lleida, IRB, Lleida, c/Montserrat Roig-2, 5008 Lleida, Spain.

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http://dx.doi.org/10.4061/2011/807108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3056244PMC
March 2011

Prefrontal cortex, caloric restriction and stress during aging: studies on dopamine and acetylcholine release, BDNF and working memory.

Behav Brain Res 2011 Jan 22;216(1):136-45. Epub 2010 Jul 22.

Department of Physiology, Faculty of Medicine, Universidad Complutense, Ciudad Universitaria, s/n, 28040 Madrid, Spain.

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http://linkinghub.elsevier.com/retrieve/pii/S016643281000525
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http://dx.doi.org/10.1016/j.bbr.2010.07.024DOI Listing
January 2011

[Dietary restriction and aging: a matter of calories?].

Authors:
Reinald Pamplona

Rev Esp Geriatr Gerontol 2010 Jul-Aug;45(4):232-8. Epub 2010 May 31.

Departamento de Medicina Experimental, Universidad de Lleida-IRBLleida, Lleida, Spain.

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http://dx.doi.org/10.1016/j.regg.2010.05.001DOI Listing
December 2010