Publications by authors named "Regis Brion"

36Publications

The YAP/TEAD Axis as a New Therapeutic Target in Osteosarcoma: Effect of Verteporfin and CA3 on Primary Tumor Growth.

Authors:
Sarah Morice Mathilde Mullard Regis Brion Maryne Dupuy Sarah Renault Robel Tesfaye Bénédicte Brounais-Le Royer Benjamin Ory Françoise Redini Franck Verrecchia

Cancers (Basel) 2020 Dec 20;12(12). Epub 2020 Dec 20.

INSERM UMR1238 "Bone Sarcomas and Remodeling of Calcified Tissues", Nantes University, F-44035 Nantes, France.

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December 2020

The twin cytokines interleukin-34 and CSF-1: masterful conductors of macrophage homeostasis.

Authors:
Javier Muñoz-Garcia Denis Cochonneau Stéphane Télétchéa Emilie Moranton Didier Lanoe Régis Brion Frédéric Lézot Marie-Françoise Heymann Dominique Heymann

Theranostics 2021 1;11(4):1568-1593. Epub 2021 Jan 1.

Université de Nantes, Institut de Cancérologie de l'Ouest, Saint-Herblain, F-44805, France.

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January 2021

Sonic Hedgehog Signature in Pediatric Primary Bone Tumors: Effects of the GLI Antagonist GANT61 on Ewing's Sarcoma Tumor Growth.

Authors:
Mathilde Mullard Marie Cadé Sarah Morice Maryne Dupuy Geoffroy Danieau Jérome Amiaud Sarah Renault Frédéric Lézot Régis Brion Rose Anne Thepault Benjamin Ory François Lamoureux Isabelle Corre Bénédicte Brounais-LeRoyer Françoise Rédini Franck Verrecchia

Cancers (Basel) 2020 Nov 19;12(11). Epub 2020 Nov 19.

INSERM, UMR1238 "Bone Sarcomas and Remodeling of Calcified Tissues", Nantes University, F44035 Nantes, France.

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November 2020

Hemophilia A and B mice, but not VWFmice, display bone defects in congenital development and remodeling after injury.

Authors:
Sarah Taves Junjiang Sun Eric W Livingston Xin Chen Jerome Amiaud Regis Brion William B Hannah Ted A Bateman Dominique Heymann Paul E Monahan

Sci Rep 2019 10 8;9(1):14428. Epub 2019 Oct 8.

Gene Therapy Center, University of North Carolina, Chapel Hill, NC, USA.

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October 2019

Jaw osteosarcoma models in mice: first description.

Authors:
Hélios Bertin Romain Guilho Régis Brion Jérôme Amiaud Séverine Battaglia Anne Moreau Anne Brouchet-Gomez Julie Longis Benoit Piot Dominique Heymann Pierre Corre Françoise Rédini

J Transl Med 2019 02 27;17(1):56. Epub 2019 Feb 27.

Laboratoire des sarcomes osseux et remodelage des tissus calcifiés (Phy.OS), UMR 1238, Faculté de médecine, 1 rue Gaston Veil, 44035, Nantes Cedex, France.

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February 2019

The Intrinsic and Extrinsic Implications of RANKL/RANK Signaling in Osteosarcoma: From Tumor Initiation to Lung Metastases.

Authors:
Benjamin Navet Kosei Ando Jorge William Vargas-Franco Régis Brion Jérome Amiaud Kanji Mori Hideo Yagita Christopher G Mueller Franck Verrecchia Clotilde Dumars Marie-Françoise Heymann Dominique Heymann Frédéric Lézot

Cancers (Basel) 2018 Oct 24;10(11). Epub 2018 Oct 24.

INSERM, UMR 1238, Faculté de Médecine, Université de Nantes, F-44035 Nantes, France.

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October 2018

In vitro and in vivo discrepancy in inducing apoptosis by mesenchymal stromal cells delivering membrane-bound tumor necrosis factor-related apoptosis inducing ligand in osteosarcoma pre-clinical models.

Authors:
Romain Guiho Kevin Biteau Giulia Grisendi Mathias Chatelais Regis Brion Julien Taurelle Sarah Renault Dominique Heymann Massimo Dominici Françoise Redini

Cytotherapy 2018 08 6;20(8):1037-1045. Epub 2018 Aug 6.

Sarcomes osseux et remodelage des tissus calcifiés, Université Bretagne Loire, INSERM, Nantes, France. Electronic address:

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August 2018

Connexin43 intercellular communication drives the early differentiation of human bone marrow stromal cells into osteoblasts.

Authors:
Julie Talbot Régis Brion Audrey Lamora Mathilde Mullard Sarah Morice Dominique Heymann Franck Verrecchia

J Cell Physiol 2018 Feb 23;233(2):946-957. Epub 2017 May 23.

INSERM, UMR 957, Nantes, France.

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February 2018

IL-38 overexpression induces anti-inflammatory effects in mice arthritis models and in human macrophages in vitro.

Authors:
Marie-Astrid Boutet Aurélie Najm Géraldine Bart Régis Brion Sophie Touchais Valérie Trichet Pierre Layrolle Cem Gabay Gaby Palmer Frédéric Blanchard Benoit Le Goff

Ann Rheum Dis 2017 Jul 13;76(7):1304-1312. Epub 2017 Mar 13.

INSERM, UMR 957, Equipe Labellisée LIGUE 2012, Nantes, France.

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July 2017

Interaction of Cutibacterium ( formerly Propionibacterium) acnes with bone cells: a step toward understanding bone and joint infection development.

Authors:
Guillaume Ghislain Aubin Marc Baud'huin Jean-Philippe Lavigne Régis Brion François Gouin Didier Lepelletier Cédric Jacqueline Dominique Heymann Karim Asehnoune Stéphane Corvec

Sci Rep 2017 02 20;7:42918. Epub 2017 Feb 20.

Bacteriology and Hygiene Unit, CHU NANTES, France.

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February 2017

Bone Morphogenetic Protein 2 and Transforming Growth Factor β1 Inhibit the Expression of the Proinflammatory Cytokine IL-34 in Rheumatoid Arthritis Synovial Fibroblasts.

Authors:
Marguerite Chemel Regis Brion Aude-Isabelle Segaliny Audrey Lamora Celine Charrier Benedicte Brulin Yves Maugars Benoit Le Goff Dominique Heymann Franck Verrecchia

Am J Pathol 2017 Jan 17;187(1):156-162. Epub 2016 Nov 17.

French National Cancer League Team 2012, INSERM, UMR 957, Nantes, France; Pathophysiology of Bone Resorption and Primary Bone Tumors Laboratory, Université de Nantes, Nantes, France. Electronic address:

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January 2017

Low-Dose Pesticide Mixture Induces Senescence in Normal Mesenchymal Stem Cells (MSC) and Promotes Tumorigenic Phenotype in Premalignant MSC.

Authors:
Mazene Hochane Valerie Trichet Claire Pecqueur Pierre Avril Lisa Oliver Jerome Denis Regis Brion Jerome Amiaud Alain Pineau Philippe Naveilhan Dominique Heymann François M Vallette Christophe Olivier

Stem Cells 2017 03 23;35(3):800-811. Epub 2016 Nov 23.

Centre de Recherche en Cancérologie Nantes Angers UMR INSERM 892, CNRS 6299 - Equipe 9, Université de Nantes, Nantes, France.

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March 2017

ΔNp63α Silences a miRNA Program to Aberrantly Initiate a Wound-Healing Program That Promotes TGFβ-Induced Metastasis.

Authors:
Lidia Rodriguez Calleja Camille Jacques François Lamoureux Marc Baud'huin Marta Tellez Gabriel Thibaut Quillard Debashish Sahay Pierre Perrot Jerome Amiaud Celine Charrier Regis Brion Fernando Lecanda Franck Verrecchia Dominique Heymann Leif W Ellisen Benjamin Ory

Cancer Res 2016 06 17;76(11):3236-51. Epub 2016 Mar 17.

INSERM, UMR-S 957, Nantes, Equipe labellisée LIGUE 2012, France. Physiopathologie de la Résorption Osseuse et Thérapie des Tumeurs Osseuses Primitives, Université de Nantes, Nantes Atlantique Universités, Rue Gaston Veil, Nantes, France.

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June 2016

Pathogenic potential of Escherichia coli clinical strains from orthopedic implant infections towards human osteoblastic cells.

Authors:
Lise Crémet Alexis Broquet Bénédicte Brulin Cédric Jacqueline Sandie Dauvergne Régis Brion Karim Asehnoune Stéphane Corvec Dominique Heymann Nathalie Caroff

Pathog Dis 2015 Nov 1;73(8):ftv065. Epub 2015 Sep 1.

UPRES EA3826, Laboratory of Clinical and Experimental Therapeutics of Infections., Medicine Faculty, University of Nantes, 1, rue G. Veil, F-44000 Nantes, France

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November 2015

Human breast cancer cells educate macrophages toward the M2 activation status.

Authors:
Sofia Sousa Régis Brion Minnamaija Lintunen Pauliina Kronqvist Jouko Sandholm Jukka Mönkkönen Pirkko-Liisa Kellokumpu-Lehtinen Susanna Lauttia Olli Tynninen Heikki Joensuu Dominique Heymann Jorma A Määttä

Breast Cancer Res 2015 Aug 5;17:101. Epub 2015 Aug 5.

School of Pharmacy, Faculty of Health Sciences, University of Eastern Finland, Yliopistonranta 1C, P.O. Box 1627, FI-70211, Kuopio, Finland.

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August 2015

IL-34 and M-CSF form a novel heteromeric cytokine and regulate the M-CSF receptor activation and localization.

Authors:
Aude I Ségaliny Régis Brion Bénédicte Brulin Mike Maillasson Céline Charrier Stéphane Téletchéa Dominique Heymann

Cytokine 2015 Dec 19;76(2):170-181. Epub 2015 Jun 19.

INSERM, UMR 957, Equipe Ligue 2012, Nantes F-44035, France; Université de Nantes, Laboratoire de Physiopathologie de la Résorption Osseuse et Thérapie des Tumeurs Osseuses Primitives, France; Centre hospitalier universitaire de Nantes, France. Electronic address:

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December 2015

Anticancer activity of halofuginone in a preclinical model of osteosarcoma: inhibition of tumor growth and lung metastases.

Authors:
Audrey Lamora Mathilde Mullard Jérôme Amiaud Régis Brion Dominique Heymann Françoise Redini Franck Verrecchia

Oncotarget 2015 Jun;6(16):14413-27

INSERM, UMR 957, Equipe Labellisée Ligue contre le Cancer 2012, Nantes, France.

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June 2015

Syndecan-1 regulates the biological activities of interleukin-34.

Authors:
Aude I Segaliny Regis Brion Erwan Mortier Mike Maillasson Michel Cherel Yannick Jacques Benoît Le Goff Dominique Heymann

Biochim Biophys Acta 2015 May 4;1853(5):1010-21. Epub 2015 Feb 4.

INSERM, UMR 957, Equipe Ligue 2012, Nantes F-44035, France; Université de Nantes, Laboratoire de Physiopathologie de la Résorption Osseuse et Thérapie des Tumeurs Osseuses Primitives, France; Centre hospitalier universitaire de Nantes, France. Electronic address:

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May 2015

IL-1β and TNFα promote monocyte viability through the induction of GM-CSF expression by rheumatoid arthritis synovial fibroblasts.

Authors:
Christelle Darrieutort-Laffite Marie-Astrid Boutet Mathias Chatelais Régis Brion Frédéric Blanchard Dominique Heymann Benoit Le Goff

Mediators Inflamm 2014 17;2014:241840. Epub 2014 Nov 17.

INSERM, UMR 957, 44035 Nantes, France ; Rheumatology Unit, Nantes University Hospital, 44093 Nantes, France ; Université de Nantes, Nantes Atlantique Universités, Laboratoire de Physiopathologie de la Résorption Osseuse et Thérapie des Tumeurs Osseuses Primitives, Faculté de Médecine, 44035 Nantes, France.

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July 2015

Interleukin-34 promotes tumor progression and metastatic process in osteosarcoma through induction of angiogenesis and macrophage recruitment.

Authors:
Aude I Ségaliny Amel Mohamadi Blandine Dizier Anna Lokajczyk Régis Brion Rachel Lanel Jérôme Amiaud Céline Charrier Catherine Boisson-Vidal Dominique Heymann

Int J Cancer 2015 Jul 13;137(1):73-85. Epub 2014 Dec 13.

INSERM, UMR 957, Equipe LIGUE Nationale Contre le Cancer 2012, Nantes, 44035, France; Université de Nantes, Nantes atlantique universités, Pathophysiology of Bone Resorption and Therapy of Primary Bone Tumours, Nantes, France.

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July 2015