Rebecca Nagy

Rebecca Nagy

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Rebecca Nagy

Rebecca Nagy

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Circulating Tumor DNA Sequencing Analysis of Gastroesophageal Adenocarcinoma.

Authors:
Steven B Maron Leah M Chase Samantha Lomnicki Sara Kochanny Kelly L Moore Smita S Joshi Stacie Landron Julie Johnson Lesli A Kiedrowski Rebecca J Nagy Richard B Lanman Seung Tae Kim Jeeyun Lee Daniel V T Catenacci

Clin Cancer Res 2019 Dec 19;25(23):7098-7112. Epub 2019 Aug 19.

The University of Chicago Medical Center, Chicago, Illinois.

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http://dx.doi.org/10.1158/1078-0432.CCR-19-1704DOI Listing
December 2019

Treatment with Next-Generation ALK Inhibitors Fuels Plasma Mutation Diversity.

Authors:
Ibiayi Dagogo-Jack Marguerite Rooney Jessica J Lin Rebecca J Nagy Beow Y Yeap Harper Hubbeling Emily Chin Jennifer Ackil Anna F Farago Aaron N Hata Jochen K Lennerz Justin F Gainor Richard B Lanman Alice T Shaw

Clin Cancer Res 2019 Nov 29;25(22):6662-6670. Epub 2019 Jul 29.

Massachusetts General Hospital Cancer Center and Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts.

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http://dx.doi.org/10.1158/1078-0432.CCR-19-1436DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6858956PMC
November 2019

Comprehensive Analysis of Alterations in Circulating Tumor DNA from Patients with Advanced Prostate Cancer.

Authors:
Elisa M Ledet Michael B Lilly Guru Sonpavde Edwin Lin Roberto H Nussenzveig Pedro C Barata Mark Yandell Rebecca J Nagy Lesli Kiedrowski Neeraj Agarwal Oliver Sartor

Oncologist 2019 Nov 11. Epub 2019 Nov 11.

Tulane Cancer Center, New Orleans, Louisiana, USA

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http://dx.doi.org/10.1634/theoncologist.2019-0115DOI Listing
November 2019

Safety and Efficacy of T-DM1 Plus Neratinib in Patients With Metastatic HER2-Positive Breast Cancer: NSABP Foundation Trial FB-10.

Authors:
Jame Abraham Albert J Montero Rachel C Jankowitz Mohamad Adham Salkeni Jan H Beumer Brian F Kiesel Fanny Piette Laura M Adamson Rebecca J Nagy Richard B Lanman Jeff Sperinde Weidong Huang Carmen J Allegra Ashok Srinivasan Ying Wang Katherine L Pogue-Geile Peter C Lucas Samuel A Jacobs

J Clin Oncol 2019 Oct 23;37(29):2601-2609. Epub 2019 Aug 23.

NSABP Foundation, Pittsburgh, PA.

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http://dx.doi.org/10.1200/JCO.19.00858DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6784849PMC
October 2019

Identification of osimertinib-resistant L792 mutations by cfDNA sequencing: oncogenic activity assessment and prevalence in large cfDNA cohort.

Authors:
Stephen R Fairclough Lesli A Kiedrowski Jessica J Lin Ori Zelichov Gabi Tarcic Thomas E Stinchcombe Justin I Odegaard Richard B Lanman Alice T Shaw Rebecca J Nagy

Exp Hematol Oncol 2019 11;8:24. Epub 2019 Oct 11.

Guardant Health, Inc., 505 Penobscot Dr, Redwood City, CA 94063 USA.

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http://dx.doi.org/10.1186/s40164-019-0148-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6788107PMC
October 2019

Resistance to TRK inhibition mediated by convergent MAPK pathway activation.

Authors:
Emiliano Cocco Alison M Schram Amanda Kulick Sandra Misale Helen H Won Rona Yaeger Pedram Razavi Ryan Ptashkin Jaclyn F Hechtman Eneda Toska James Cownie Romel Somwar Sophie Shifman Marissa Mattar S Duygu Selçuklu Aliaksandra Samoila Sean Guzman Brian B Tuch Kevin Ebata Elisa de Stanchina Rebecca J Nagy Richard B Lanman Brian Houck-Loomis Juber A Patel Michael F Berger Marc Ladanyi David M Hyman Alexander Drilon Maurizio Scaltriti

Nat Med 2019 09 12;25(9):1422-1427. Epub 2019 Aug 12.

Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA.

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http://dx.doi.org/10.1038/s41591-019-0542-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6736691PMC
September 2019

Mutations Classes I, II, and III in NSCLC Patients Included in the SLLIP Trial: The Need for a New Pre-Clinical Treatment Rationale.

Authors:
Jillian Wilhelmina Paulina Bracht Niki Karachaliou Trever Bivona Richard B Lanman Iris Faull Rebecca J Nagy Ana Drozdowskyj Jordi Berenguer Manuel Fernandez-Bruno Miguel Angel Molina-Vila Rafael Rosell

Cancers (Basel) 2019 Sep 17;11(9). Epub 2019 Sep 17.

Pangaea Oncology, Laboratory of Molecular Biology, Quirón-Dexeus University Institute, 08028 Barcelona, Spain.

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http://dx.doi.org/10.3390/cancers11091381DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6770188PMC
September 2019

Feasibility of circulating tumor DNA testing in hepatocellular carcinoma.

Authors:
Kabir Mody Pashtoon Murtaza Kasi Ju Dong Yang Phani Keerthi Surapaneni Ashton Ritter Ali Roberts Rebecca Nagy Mitesh J Borad

J Gastrointest Oncol 2019 Aug;10(4):745-750

Division of Hematology/Oncology, Mayo Clinic Cancer Center, Mayo Clinic, Scottsdale, AZ, USA.

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http://dx.doi.org/10.21037/jgo.2019.02.10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6657310PMC
August 2019

Therapeutic outcomes in non-small cell lung cancer with mutations: a single institution, retrospective cohort study.

Authors:
Irena Tan Thomas E Stinchcombe Neal E Ready Jeffrey Crawford Michael B Datto Rebecca J Nagy Richard B Lanman Lin Gu Jeffrey M Clarke

Transl Lung Cancer Res 2019 Jun;8(3):258-267

Duke Cancer Institute, Duke University Medical Center, Durham, NC, USA.

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http://dx.doi.org/10.21037/tlcr.2019.04.03DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6626861PMC
June 2019

Circulating tumor DNA alterations in patients with metastatic castration-resistant prostate cancer.

Authors:
Guru Sonpavde Neeraj Agarwal Gregory Russell Pond Rebecca J Nagy Roberto H Nussenzveig Andrew W Hahn Oliver Sartor Theodore Stewart Gourdin Lakshminarayanan Nandagopal Elisa M Ledet Gurudatta Naik Andrew J Armstrong Jue Wang Mehmet Asim Bilen Shilpa Gupta Petros Grivas Sumanta K Pal Richard B Lanman AmirAli Talasaz Michael B Lilly

Cancer 2019 May 8;125(9):1459-1469. Epub 2019 Jan 8.

Hollings Cancer Center, Medical University of South Carolina, Charleston, South Carolina.

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http://dx.doi.org/10.1002/cncr.31959DOI Listing
May 2019

Molecular Analysis of Plasma From Patients With ROS1-Positive NSCLC.

Authors:
Ibiayi Dagogo-Jack Marguerite Rooney Rebecca J Nagy Jessica J Lin Emily Chin Lorin A Ferris Jennifer Ackil Jochen K Lennerz Richard B Lanman Justin F Gainor Alice T Shaw

J Thorac Oncol 2019 May 18;14(5):816-824. Epub 2019 Jan 18.

Massachusetts General Hospital Cancer Center and Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts. Electronic address:

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http://dx.doi.org/10.1016/j.jtho.2019.01.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6486857PMC
May 2019

Plasma HER2 () Copy Number Predicts Response to HER2-targeted Therapy in Metastatic Colorectal Cancer.

Authors:
Giulia Siravegna Andrea Sartore-Bianchi Rebecca J Nagy Kanwal Raghav Justin I Odegaard Richard B Lanman Livio Trusolino Silvia Marsoni Salvatore Siena Alberto Bardelli

Clin Cancer Res 2019 May 26;25(10):3046-3053. Epub 2019 Feb 26.

Candiolo Cancer Institute, FPO-IRCCS, Candiolo, Torino, Italy.

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http://dx.doi.org/10.1158/1078-0432.CCR-18-3389DOI Listing
May 2019

Aberrant FGFR signaling mediates resistance to CDK4/6 inhibitors in ER+ breast cancer.

Authors:
Luigi Formisano Yao Lu Alberto Servetto Ariella B Hanker Valerie M Jansen Joshua A Bauer Dhivya R Sudhan Angel L Guerrero-Zotano Sarah Croessmann Yan Guo Paula Gonzalez Ericsson Kyung-Min Lee Mellissa J Nixon Luis J Schwarz Melinda E Sanders Teresa C Dugger Marcelo Rocha Cruz Amir Behdad Massimo Cristofanilli Aditya Bardia Joyce O'Shaughnessy Rebecca J Nagy Richard B Lanman Nadia Solovieff Wei He Michelle Miller Fei Su Yu Shyr Ingrid A Mayer Justin M Balko Carlos L Arteaga

Nat Commun 2019 03 26;10(1):1373. Epub 2019 Mar 26.

Departments of Medicine, Vanderbilt University Medical Center, Nashville, 37232-6307, TN, USA.

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http://www.nature.com/articles/s41467-019-09068-2
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http://dx.doi.org/10.1038/s41467-019-09068-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6435685PMC
March 2019

Circulating Tumor DNA Alterations in Advanced Urothelial Carcinoma and Association with Clinical Outcomes: A Pilot Study.

Authors:
Petros Grivas Aly-Khan A Lalani Gregory R Pond Rebecca J Nagy Bishoy Faltas Neeraj Agarwal Sumati V Gupta Alexandra Drakaki Ulka N Vaishampayan Jue Wang Pedro C Barata Dharmesh Gopalakrishnan Gurudatta Naik Bradley A McGregor Lesli A Kiedrowski Richard B Lanman Guru P Sonpavde

Eur Urol Oncol 2019 Mar 9. Epub 2019 Mar 9.

Lank Center for Genitourinary Oncology, Dana-Farber Cancer Institute, Boston, MA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.euo.2019.02.004DOI Listing
March 2019

Fine mapping of 14q13 reveals novel variants associated with different histological subtypes of papillary thyroid carcinoma.

Authors:
Jarosław Jendrzejewski Sandya Liyanarachchi Andrew Eiterman Andrew Thomas Huiling He Rebecca Nagy Leigha Senter Krzysztof Sworczak Albert de la Chapelle

Int J Cancer 2019 02 3;144(3):503-512. Epub 2018 Dec 3.

Human Cancer Genetics Program and Department of Cancer Biology and Genetics, Comprehensive Cancer Center, The Ohio State University, Columbus, OH.

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http://doi.wiley.com/10.1002/ijc.31933
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http://dx.doi.org/10.1002/ijc.31933DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294684PMC
February 2019

and Amplifications Determine Response to HER2 Inhibition in -Amplified Esophagogastric Cancer.

Authors:
Francisco Sanchez-Vega Jaclyn F Hechtman Pau Castel Geoffrey Y Ku Yaelle Tuvy Helen Won Christopher J Fong Nancy Bouvier Gouri J Nanjangud Joanne Soong Efsevia Vakiani Mark Schattner David P Kelsen Robert A Lefkowitz Karen Brown Mario E Lacouture Marinela Capanu Marissa Mattar Besnik Qeriqi Fabiola Cecchi Yuan Tian Todd Hembrough Rebecca J Nagy Richard B Lanman Steven M Larson Neeta Pandit-Taskar Heiko Schöder Christine A Iacobuzio-Donahue David H Ilson Wolfgang A Weber Michael F Berger Elisa de Stanchina Barry S Taylor Jason S Lewis David B Solit Jorge A Carrasquillo Maurizio Scaltriti Nikolaus Schultz Yelena Y Janjigian

Cancer Discov 2019 02 21;9(2):199-209. Epub 2018 Nov 21.

Department of Medicine, Memorial Sloan Kettering Cancer Center and Weill Cornell Medical College, New York, New York.

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http://dx.doi.org/10.1158/2159-8290.CD-18-0598DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368868PMC
February 2019

Correction: An Acquired Gatekeeper Mutation Induces Resistance to Neratinib in a Patient with HER2 Mutant-Driven Breast Cancer.

Authors:
Ariella B Hanker Monica Red Brewer Jonathan H Sheehan James P Koch Gregory R Sliwoski Rebecca Nagy Richard Lanman Michael F Berger David M Hyman David B Solit Jie He Vincent Miller Richard E Cutler Alshad S Lalani Darren Cross Christine M Lovly Jens Meiler Carlos L Arteaga

Cancer Discov 2019 Feb;9(2):303

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http://cancerdiscovery.aacrjournals.org/lookup/doi/10.1158/2
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http://dx.doi.org/10.1158/2159-8290.CD-18-1515DOI Listing
February 2019

Correction: C2 Domain Deletions Hyperactivate Phosphoinositide 3-kinase (PI3K), Generate Oncogene Dependence, and Are Exquisitely Sensitive to PI3Kα Inhibitors.

Authors:
Sarah Croessmann Jonathan H Sheehan Kyung-Min Lee Gregory Sliwoski Jie He Rebecca Nagy David Riddle Ingrid A Mayer Justin M Balko Richard Lanman Vincent A Miller Lewis C Cantley Jens Meiler Carlos L Arteaga

Clin Cancer Res 2019 Feb;25(4):1432

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http://dx.doi.org/10.1158/1078-0432.CCR-18-4269DOI Listing
February 2019

Combined Blockade of Activating Mutations and ER Results in Synthetic Lethality of ER+/HER2 Mutant Breast Cancer.

Authors:
Sarah Croessmann Luigi Formisano Lisa N Kinch Paula I Gonzalez-Ericsson Dhivya R Sudhan Rebecca J Nagy Aju Mathew Eric H Bernicker Massimo Cristofanilli Jie He Richard E Cutler Alshad S Lalani Vincent A Miller Richard B Lanman Nick V Grishin Carlos L Arteaga

Clin Cancer Res 2019 01 12;25(1):277-289. Epub 2018 Oct 12.

Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee.

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http://clincancerres.aacrjournals.org/lookup/doi/10.1158/107
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http://dx.doi.org/10.1158/1078-0432.CCR-18-1544DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6320312PMC
January 2019

Amplification of Wild-type Imparts Resistance to Crizotinib in Exon 14 Mutant Non-Small Cell Lung Cancer.

Authors:
Magda Bahcall Mark M Awad Lynette M Sholl Frederick H Wilson Man Xu Stephen Wang Sangeetha Palakurthi Jihyun Choi Elena V Ivanova Giulia C Leonardi Bryan C Ulrich Cloud P Paweletz Paul T Kirschmeier Masayuki Watanabe Hideo Baba Mizuki Nishino Rebecca J Nagy Richard B Lanman Marzia Capelletti Emily S Chambers Amanda J Redig Paul A VanderLaan Daniel B Costa Yu Imamura Pasi A Jänne

Clin Cancer Res 2018 12 2;24(23):5963-5976. Epub 2018 Aug 2.

Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts.

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http://clincancerres.aacrjournals.org/lookup/doi/10.1158/107
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http://dx.doi.org/10.1158/1078-0432.CCR-18-0876DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6279568PMC
December 2018

Landscape of Acquired Resistance to Osimertinib in -Mutant NSCLC and Clinical Validation of Combined EGFR and RET Inhibition with Osimertinib and BLU-667 for Acquired Fusion.

Authors:
Zofia Piotrowska Hideko Isozaki Jochen K Lennerz Justin F Gainor Inga T Lennes Viola W Zhu Nicolas Marcoux Mandeep K Banwait Subba R Digumarthy Wenjia Su Satoshi Yoda Amanda K Riley Varuna Nangia Jessica J Lin Rebecca J Nagy Richard B Lanman Dora Dias-Santagata Mari Mino-Kenudson A John Iafrate Rebecca S Heist Alice T Shaw Erica K Evans Corinne Clifford Sai-Hong I Ou Beni Wolf Aaron N Hata Lecia V Sequist

Cancer Discov 2018 12 26;8(12):1529-1539. Epub 2018 Sep 26.

Massachusetts General Hospital Cancer Center, Boston, Massachusetts.

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http://cancerdiscovery.aacrjournals.org/lookup/doi/10.1158/2
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http://dx.doi.org/10.1158/2159-8290.CD-18-1022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6279502PMC
December 2018

Emergence of a RET V804M Gatekeeper Mutation During Treatment With Vandetanib in RET-Rearranged NSCLC.

Authors:
Ibiayi Dagogo-Jack Sara E Stevens Jessica J Lin Rebecca Nagy Lorin Ferris Alice T Shaw Justin F Gainor

J Thorac Oncol 2018 11;13(11):e226-e227

Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S15560864183077
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http://dx.doi.org/10.1016/j.jtho.2018.06.021DOI Listing
November 2018

Identification of Incidental Germline Mutations in Patients With Advanced Solid Tumors Who Underwent Cell-Free Circulating Tumor DNA Sequencing.

Authors:
Thomas P Slavin Kimberly C Banks Darya Chudova Geoffrey R Oxnard Justin I Odegaard Rebecca J Nagy Kar Wing Kevin Tsang Susan L Neuhausen Stacy W Gray Massimo Cristofanilli Angel A Rodriguez Aditya Bardia Brian Leyland-Jones Mike F Janicek Michael Lilly Guru Sonpavde Christine E Lee Richard B Lanman Funda Meric-Bernstam Razelle Kurzrock Jeffrey N Weitzel

J Clin Oncol 2018 Oct 19:JCO1800328. Epub 2018 Oct 19.

Thomas P. Slavin, Kar Wing Kevin Tsang, Susan L. Neuhausen, Stacy W. Gray, and Jeffrey N. Weitzel, City of Hope, Duarte; Kimberly C. Banks, Darya Chudova, Justin I. Odegaard, Rebecca J. Nagy, Christine E. Lee, and Richard B. Lanman, Guardant Health, Redwood City; Razelle Kurzrock, University of California, San Diego, Moores Cancer Center, San Diego, CA; Geoffrey R. Oxnard, Dana-Farber Cancer Institute; Aditya Bardia, Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston, MA; Massimo Cristofanilli, Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, IL; Angel A. Rodriguez, Houston Methodist Hospital; Funda Meric-Bernstam, The University of Texas MD Anderson Cancer Center, Houston, TX; Brian Leyland-Jones, Avera Cancer Institute, Sioux Falls, SD; Mike F. Janicek, Arizona Oncology Associates Gynecology Oncology, Scottsdale, AZ; Michael Lilly, Medical University of South Carolina, Charleston, SC; and Guru Sonpavde, The University of Alabama at Birmingham Comprehensive Cancer Center, Birmingham, AL.

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http://ascopubs.org/doi/10.1200/JCO.18.00328
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http://dx.doi.org/10.1200/JCO.18.00328DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6286162PMC
October 2018

Real-time Genomic Characterization of Advanced Pancreatic Cancer to Enable Precision Medicine.

Authors:
Andrew J Aguirre Jonathan A Nowak Nicholas D Camarda Richard A Moffitt Arezou A Ghazani Mehlika Hazar-Rethinam Srivatsan Raghavan Jaegil Kim Lauren K Brais Dorisanne Ragon Marisa W Welch Emma Reilly Devin McCabe Lori Marini Kristin Anderka Karla Helvie Nelly Oliver Ana Babic Annacarolina Da Silva Brandon Nadres Emily E Van Seventer Heather A Shahzade Joseph P St Pierre Kelly P Burke Thomas Clancy James M Cleary Leona A Doyle Kunal Jajoo Nadine J McCleary Jeffrey A Meyerhardt Janet E Murphy Kimmie Ng Anuj K Patel Kimberly Perez Michael H Rosenthal Douglas A Rubinson Marvin Ryou Geoffrey I Shapiro Ewa Sicinska Stuart G Silverman Rebecca J Nagy Richard B Lanman Deborah Knoerzer Dean J Welsch Matthew B Yurgelun Charles S Fuchs Levi A Garraway Gad Getz Jason L Hornick Bruce E Johnson Matthew H Kulke Robert J Mayer Jeffrey W Miller Paul B Shyn David A Tuveson Nikhil Wagle Jen Jen Yeh William C Hahn Ryan B Corcoran Scott L Carter Brian M Wolpin

Cancer Discov 2018 09 14;8(9):1096-1111. Epub 2018 Jun 14.

Dana-Farber Cancer Institute, Boston, Massachusetts.

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http://cancerdiscovery.aacrjournals.org/lookup/doi/10.1158/2
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http://dx.doi.org/10.1158/2159-8290.CD-18-0275DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6192263PMC
September 2018

Validation of a Plasma-Based Comprehensive Cancer Genotyping Assay Utilizing Orthogonal Tissue- and Plasma-Based Methodologies.

Authors:
Justin I Odegaard John J Vincent Stefanie Mortimer James V Vowles Bryan C Ulrich Kimberly C Banks Stephen R Fairclough Oliver A Zill Marcin Sikora Reza Mokhtari Diana Abdueva Rebecca J Nagy Christine E Lee Lesli A Kiedrowski Cloud P Paweletz Helmy Eltoukhy Richard B Lanman Darya I Chudova AmirAli Talasaz

Clin Cancer Res 2018 08 24;24(15):3539-3549. Epub 2018 Apr 24.

Guardant Health, Redwood City, California.

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http://clincancerres.aacrjournals.org/lookup/doi/10.1158/107
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http://dx.doi.org/10.1158/1078-0432.CCR-17-3831DOI Listing
August 2018

The Landscape of Actionable Genomic Alterations in Cell-Free Circulating Tumor DNA from 21,807 Advanced Cancer Patients.

Authors:
Oliver A Zill Kimberly C Banks Stephen R Fairclough Stefanie A Mortimer James V Vowles Reza Mokhtari David R Gandara Philip C Mack Justin I Odegaard Rebecca J Nagy Arthur M Baca Helmy Eltoukhy Darya I Chudova Richard B Lanman AmirAli Talasaz

Clin Cancer Res 2018 08 18;24(15):3528-3538. Epub 2018 May 18.

Guardant Health, Inc., Redwood City, California.

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http://dx.doi.org/10.1158/1078-0432.CCR-17-3837DOI Listing
August 2018

Cell-Free DNA Profiling to Discover Mechanisms of Exceptional Response to Cabozantinib Plus Panitumumab in a Patient With Treatment Refractory Metastatic Colorectal Cancer.

Authors:
Jingquan Jia Michael A Morse Rebecca J Nagy Richard B Lanman John H Strickler

Front Oncol 2018 28;8:305. Epub 2018 Aug 28.

Department of Medicine, Duke University Medical Center, Durham, NC, United States.

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https://www.frontiersin.org/article/10.3389/fonc.2018.00305/
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http://dx.doi.org/10.3389/fonc.2018.00305DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6121109PMC
August 2018

Penetrance of a rare familial mutation predisposing to papillary thyroid cancer.

Authors:
Donika Saporito Pamela Brock Heather Hampel Jennifer Sipos Soledad Fernandez Sandya Liyanarachchi Albert de la Chapelle Rebecca Nagy

Fam Cancer 2018 07;17(3):431-434

Senior Medical Science Liaison, Guardant Health, Redwood City, CA, USA.

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http://dx.doi.org/10.1007/s10689-017-0048-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5897192PMC
July 2018

Radiologic and Genomic Evolution of Individual Metastases during HER2 Blockade in Colorectal Cancer.

Authors:
Giulia Siravegna Luca Lazzari Giovanni Crisafulli Andrea Sartore-Bianchi Benedetta Mussolin Andrea Cassingena Cosimo Martino Richard B Lanman Rebecca J Nagy Stephen Fairclough Giuseppe Rospo Giorgio Corti Alice Bartolini Pamela Arcella Monica Montone Francesca Lodi Annalisa Lorenzato Alice Vanzati Emanuele Valtorta Giovanni Cappello Andrea Bertotti Sara Lonardi Vittorina Zagonel Francesco Leone Mariangela Russo Antonella Balsamo Mauro Truini Federica Di Nicolantonio Alessio Amatu Erica Bonazzina Silvia Ghezzi Daniele Regge Angelo Vanzulli Livio Trusolino Salvatore Siena Silvia Marsoni Alberto Bardelli

Cancer Cell 2018 07;34(1):148-162.e7

Candiolo Cancer Institute-FPO, IRCCS, Candiolo, TO, Italy; Department of Oncology, University of Torino, Candiolo, TO 10060, Italy. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2018.06.004DOI Listing
July 2018

Heterogeneity and Coexistence of T790M and T790 Wild-Type Resistant Subclones Drive Mixed Response to Third-Generation Epidermal Growth Factor Receptor Inhibitors in Lung Cancer.

Authors:
Zofia Piotrowska Mehlika Hazar-Rethinam Coleen Rizzo Brandon Nadres Emily E Van Seventer Heather A Shahzade Inga T Lennes Anthony J Iafrate Dora Dias-Santagata Ignaty Leshchiner Nicholas A Jessop Haichuan Hu Subba R Digumarthy Rebecca J Nagy Richard B Lanman Susan Moody Matthew J Niederst Jeffrey A Engelman Aaron N Hata Ryan B Corcoran Lecia V Sequist

JCO Precis Oncol 2018 16;2018. Epub 2018 Jul 16.

Massachusetts General Hospital, Boston.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6097183PMC
http://dx.doi.org/10.1200/PO.17.00263DOI Listing
July 2018

Targeted Therapies for Targeted Populations: Anti-EGFR Treatment for -Amplified Gastroesophageal Adenocarcinoma.

Authors:
Steven B Maron Lindsay Alpert Heewon A Kwak Samantha Lomnicki Leah Chase David Xu Emily O'Day Rebecca J Nagy Richard B Lanman Fabiola Cecchi Todd Hembrough Alexa Schrock John Hart Shu-Yuan Xiao Namrata Setia Daniel V T Catenacci

Cancer Discov 2018 06 15;8(6):696-713. Epub 2018 Feb 15.

Department of Medicine, University of Chicago, Chicago, Illinois.

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http://dx.doi.org/10.1158/2159-8290.CD-17-1260DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5984701PMC
June 2018

Anaplastic Lymphoma Kinase Mutation ( F1174C) in Small Cell Carcinoma of the Prostate and Molecular Response to Alectinib.

Authors:
Benedito A Carneiro Sahithi Pamarthy Ami N Shah Vinay Sagar Kenji Unno HuiYing Han Ximing J Yang Rubens B Costa Rebecca J Nagy Richard B Lanman Timothy M Kuzel Jeffrey S Ross Laurie Gay Julia A Elvin Siraj M Ali Massimo Cristofanilli Young K Chae Francis J Giles Sarki A Abdulkadir

Clin Cancer Res 2018 06 20;24(12):2732-2739. Epub 2018 Mar 20.

The Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois.

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http://clincancerres.aacrjournals.org/lookup/doi/10.1158/107
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http://dx.doi.org/10.1158/1078-0432.CCR-18-0332DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6715284PMC
June 2018

Characterization of metastatic urothelial carcinoma via comprehensive genomic profiling of circulating tumor DNA.

Authors:
Neeraj Agarwal Sumanta K Pal Andrew W Hahn Roberto H Nussenzveig Gregory R Pond Sumati V Gupta Jue Wang Mehmet A Bilen Gurudatta Naik Pooja Ghatalia Christopher J Hoimes Dharmesh Gopalakrishnan Pedro C Barata Alexandra Drakaki Bishoy M Faltas Lesli A Kiedrowski Richard B Lanman Rebecca J Nagy Nicholas J Vogelzang Kenneth M Boucher Ulka N Vaishampayan Guru Sonpavde Petros Grivas

Cancer 2018 05 8;124(10):2115-2124. Epub 2018 Mar 8.

Division of Oncology, Department of Medicine, University of Washington, Fred Hutchinson Cancer Research Center, Seattle, Washington.

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http://dx.doi.org/10.1002/cncr.31314DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6857169PMC
May 2018

C2 Domain Deletions Hyperactivate Phosphoinositide 3-kinase (PI3K), Generate Oncogene Dependence, and Are Exquisitely Sensitive to PI3K Inhibitors.

Authors:
Sarah Croessmann Jonathan H Sheehan Kyung-Min Lee Gregory Sliwoski Jie He Rebecca Nagy David Riddle Ingrid A Mayer Justin M Balko Richard Lanman Vincent A Miller Lewis C Cantley Jens Meiler Carlos L Arteaga

Clin Cancer Res 2018 03 28;24(6):1426-1435. Epub 2017 Dec 28.

Department of Medicine, Vanderbilt University, Nashville, Tennessee.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5856622PMC
March 2018

Cell-Free DNA and Circulating Tumor Cells: Comprehensive Liquid Biopsy Analysis in Advanced Breast Cancer.

Authors:
Giovanna Rossi Zhaomei Mu Alfred W Rademaker Laura K Austin Kimberly S Strickland Ricardo Lima Barros Costa Rebecca J Nagy Vittorina Zagonel Timothy J Taxter Amir Behdad Firas H Wehbe Leonidas C Platanias William J Gradishar Massimo Cristofanilli

Clin Cancer Res 2018 02 27;24(3):560-568. Epub 2017 Nov 27.

Department of Medicine-Hematology and Oncology, Robert H. Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, Illinois.

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http://dx.doi.org/10.1158/1078-0432.CCR-17-2092DOI Listing
February 2018

Genomic Landscape of Cell-Free DNA in Patients with Colorectal Cancer.

Authors:
John H Strickler Jonathan M Loree Leanne G Ahronian Aparna R Parikh Donna Niedzwiecki Allan Andresson Lima Pereira Matthew McKinney W Michael Korn Chloe E Atreya Kimberly C Banks Rebecca J Nagy Funda Meric-Bernstam Richard B Lanman AmirAli Talasaz Igor F Tsigelny Ryan B Corcoran Scott Kopetz

Cancer Discov 2018 02 1;8(2):164-173. Epub 2017 Dec 1.

The University of Texas MD Anderson Cancer Center, Houston, Texas.

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http://dx.doi.org/10.1158/2159-8290.CD-17-1009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5809260PMC
February 2018

Genomic Heterogeneity as a Barrier to Precision Medicine in Gastroesophageal Adenocarcinoma.

Authors:
Eirini Pectasides Matthew D Stachler Sarah Derks Yang Liu Steven Maron Mirazul Islam Lindsay Alpert Heewon Kwak Hedy Kindler Blase Polite Manish R Sharma Kenisha Allen Emily O'Day Samantha Lomnicki Melissa Maranto Rajani Kanteti Carrie Fitzpatrick Christopher Weber Namrata Setia Shu-Yuan Xiao John Hart Rebecca J Nagy Kyoung-Mee Kim Min-Gew Choi Byung-Hoon Min Katie S Nason Lea O'Keefe Masayuki Watanabe Hideo Baba Rick Lanman Agoston T Agoston David J Oh Andrew Dunford Aaron R Thorner Matthew D Ducar Bruce M Wollison Haley A Coleman Yuan Ji Mitchell C Posner Kevin Roggin Kiran Turaga Paul Chang Kyle Hogarth Uzma Siddiqui Andres Gelrud Gavin Ha Samuel S Freeman Justin Rhoades Sarah Reed Greg Gydush Denisse Rotem Jon Davison Yu Imamura Viktor Adalsteinsson Jeeyun Lee Adam J Bass Daniel V Catenacci

Cancer Discov 2018 01 4;8(1):37-48. Epub 2017 Oct 4.

Department of Medicine, Section of Hematology/Oncology, University of Chicago Medical Center and Biological Sciences, Chicago, Illinois.

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http://dx.doi.org/10.1158/2159-8290.CD-17-0395DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5894850PMC
January 2018

Cancer Genetic Counseling and Testing in an Era of Rapid Change.

Authors:
Gillian W Hooker Keelia Rhoads Clemens John Quillin Kristen J Vogel Postula Pia Summerour Rebecca Nagy Adam H Buchanan

J Genet Couns 2017 Dec 22;26(6):1244-1253. Epub 2017 Apr 22.

Geisinger Health System, Danville, PA, USA.

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http://dx.doi.org/10.1007/s10897-017-0099-2DOI Listing
December 2017

Discrimination of Germline T790M Mutations in Plasma Cell-Free DNA Allows Study of Prevalence Across 31,414 Cancer Patients.

Authors:
Yuebi Hu Ryan S Alden Justin I Odegaard Stephen R Fairclough Ruthia Chen Jennifer Heng Nora Feeney Rebecca J Nagy Jayshree Shah Bryan Ulrich Martin Gutierrez Richard B Lanman Judy E Garber Cloud P Paweletz Geoffrey R Oxnard

Clin Cancer Res 2017 Dec 25;23(23):7351-7359. Epub 2017 Sep 25.

Lowe Center for Thoracic Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.

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http://dx.doi.org/10.1158/1078-0432.CCR-17-1745DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5712272PMC
December 2017

Clonal Evolution and the Role of Serial Liquid Biopsies in a Case of Small-Cell Lung Cancer-Transformed Mutant Non-Small-Cell Lung Cancer.

Authors:
Meghan J Mooradian Zofia Piotrowska Benjamin J Drapkin Dora Dias-Santagata Nicolas Marcoux Konstantinos Arnaoutakis Rebecca J Nagy Richard Lanman Anthony J Iafrate Anna F Farago Mari Mino-Kenudson Aaron N Hata Lecia V Sequist

JCO Precis Oncol 2017 7;1. Epub 2017 Nov 7.

Massachusetts General Hospital, Boston, MA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6483387PMC
November 2017

An Acquired Gatekeeper Mutation Induces Resistance to Neratinib in a Patient with HER2 Mutant-Driven Breast Cancer.

Authors:
Ariella B Hanker Monica Red Brewer Jonathan H Sheehan James P Koch Gregory R Sliwoski Rebecca Nagy Richard Lanman Michael F Berger David M Hyman David B Solit Jie He Vincent Miller Richard E Cutler Alshad S Lalani Darren Cross Christine M Lovly Jens Meiler Carlos L Arteaga

Cancer Discov 2017 06 8;7(6):575-585. Epub 2017 Mar 8.

Department of Medicine, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee.

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http://dx.doi.org/10.1158/2159-8290.CD-16-1431DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5457707PMC
June 2017

Costs of Diagnostic Assessment for Lung Cancer: A Medicare Claims Analysis.

Authors:
Tasneem Lokhandwala Marisa A Bittoni Robert A Dann Anna O D'Souza Meridith Johnson Rebecca J Nagy Richard B Lanman Robert E Merritt David P Carbone

Clin Lung Cancer 2017 01 21;18(1):e27-e34. Epub 2016 Jul 21.

Division of Thoracic Oncology, Department of Internal Medicine, Ohio State University, Columbus, OH.

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http://dx.doi.org/10.1016/j.cllc.2016.07.006DOI Listing
January 2017

Risk Factors of I-Induced Salivary Gland Damage in Thyroid Cancer Patients.

Authors:
Brynn Hollingsworth Leigha Senter Xiaoli Zhang Guy N Brock Wael Jarjour Rebecca Nagy Pamela Brock Kevin R Coombes Richard T Kloos Matthew D Ringel Jennifer Sipos Ilene Lattimer Ricardo Carrau Sissy M Jhiang

J Clin Endocrinol Metab 2016 11 17;101(11):4085-4093. Epub 2016 Aug 17.

Department of Physiology and Cell Biology (B.H., S.M.J.), Human Cancer Genetics Program, Comprehensive Cancer Center (L.S., R.N., P.B., I.L.), Center for Biostatistics (X.Z., G.N.B.), Department of Internal Medicine, Division of Rheumatology and Immunology (W.J.), Department of Biomedical Informatics (X.Z., G.N.B., K.R.C.), Department of Internal Medicine, Division of Endocrinology, Diabetes, and Metabolism (R.K., M.D.R., J.S.), Department of Internal Medicine, Division of Oncology (M.D.R.), and Department of Otolaryngology-Head & Neck Surgery (R.C.), The Ohio State University, Columbus, Ohio 43210.

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http://dx.doi.org/10.1210/jc.2016-1605DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5095242PMC
November 2016

Genetic variants in thyroid cancer distant metastases.

Authors:
Steven E Justiniano Joseph P McElroy Lianbo Yu Ayse Selen Yilmaz Kevin R Coombes Leigha Senter Rebecca Nagy Paul Wakely Stefano Volinia Michelle Vinco Thomas J Giordano Carlo M Croce Motoyasu Saji Matthew D Ringel

Endocr Relat Cancer 2016 10 19;23(10):L33-6. Epub 2016 Aug 19.

Division of EndocrinologyDiabetes, and Metabolism, The Ohio State University, Columbus, OH, USA Department of Molecular VirologyImmunology, and Genetics, The Ohio State University Wexner Medical Center and Arthur G. James Comprehensive Cancer Center, Columbus, Ohio, USA

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http://dx.doi.org/10.1530/ERC-16-0351DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5026957PMC
October 2016

Biopsy-free circulating tumor DNA assay identifies actionable mutations in lung cancer.

Authors:
Victoria Villaflor Brian Won Rebecca Nagy Kimberly Banks Richard B Lanman AmirAli Talasaz Ravi Salgia

Oncotarget 2016 Oct;7(41):66880-66891

City of Hope, Duarte, CA 91010, USA.

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http://dx.doi.org/10.18632/oncotarget.11801DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5341844PMC
October 2016

Papillary Thyroid Carcinoma: Association Between Germline DNA Variant Markers and Clinical Parameters.

Authors:
Jaroslaw Jendrzejewski Sandya Liyanarachchi Rebecca Nagy Leigha Senter Paul E Wakely Andrew Thomas Fadi Nabhan Huiling He Wei Li Krzysztof Sworczak Matthew D Ringel Lawrence S Kirschner Albert de la Chapelle

Thyroid 2016 09 22;26(9):1276-84. Epub 2016 Jul 22.

1 Human Cancer Genetics Program, Comprehensive Cancer Center, The Ohio State University , Columbus, Ohio.

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http://dx.doi.org/10.1089/thy.2015.0665DOI Listing
September 2016

Plasma T790M Result Alters Treatment Options in a Previously T790 Wild-Type EGFR-Mutant Lung Cancer.

Authors:
Zofia Piotrowska Benjamin Drapkin Jeffrey A Engelman Rebecca J Nagy Richard B Lanman Lecia V Sequist

J Thorac Oncol 2016 08 12;11(8):e95-e97. Epub 2016 Apr 12.

Massachusetts General Hospital Cancer Center, Boston, Massachusetts; Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1016/j.jtho.2016.03.020DOI Listing
August 2016

The current state of cancer genetic counseling access and availability.

Authors:
Sara Knapke Joy Larsen Haidle Rebecca Nagy Sara Pirzadeh-Miller

Genet Med 2016 Apr 6;18(4):410-2. Epub 2015 Aug 6.

Simmons Cancer Center, University of Texas South Western Medical Center, Dallas, Texas, USA.

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http://www.nature.com/articles/gim201598
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April 2016

PTCSC3 Is Involved in Papillary Thyroid Carcinoma Development by Modulating S100A4 Gene Expression.

Authors:
Jaroslaw Jendrzejewski Andrew Thomas Sandya Liyanarachchi Andrew Eiterman Jerneja Tomsic Huiling He Hanna S Radomska Wei Li Rebecca Nagy Krzysztof Sworczak Albert de la Chapelle

J Clin Endocrinol Metab 2015 Oct 14;100(10):E1370-7. Epub 2015 Aug 14.

Human Cancer Genetics Program, Comprehensive Cancer Center (J.J., A.T., S.L., A.E., J.T., H.H., H.S.R., W.L., R.N., A.d.l.C.), The Ohio State University, Columbus, Ohio, 43210; and Department of Endocrinology and Internal Medicine (J.J., K.S.), Medical University of Gdansk, Poland.

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http://dx.doi.org/10.1210/jc.2015-2247DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4596031PMC
October 2015

Genetic Counselors' and Genetic Counseling Students' Attitudes Around the Clinical Doctorate and Other Advanced Educational Options for Genetic Counselors: A Report from the Genetic Counseling Advanced Degree Task Force.

Authors:
Rebecca Nagy Holly Peay Melissa Hicks Jacqueline Kloos Rachel Westman Laura Conway Brenda Finucane Jennifer Fitzpatrick Erynn Gordon Erica Ramos Jaspreet Sekhon-Warren Josh Silver Carol Walton Catherine Reiser

J Genet Couns 2015 Aug 30;24(4):626-34. Epub 2014 Oct 30.

Division of Human Genetics, Ohio State University Wexner Medical Center/James Cancer Hospital Columbus, 2001 Polaris Parkway, Columbus, OH, 43240, USA,

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http://dx.doi.org/10.1007/s10897-014-9785-5DOI Listing
August 2015

The genetics of endocrine neoplasia.

Authors:
Rebecca Nagy

Curr Probl Cancer 2014 Nov-Dec;38(6):262-73. Epub 2014 Oct 31.

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http://dx.doi.org/10.1016/j.currproblcancer.2014.10.006DOI Listing
July 2015

A germline mutation in SRRM2, a splicing factor gene, is implicated in papillary thyroid carcinoma predisposition.

Authors:
Jerneja Tomsic Huiling He Keiko Akagi Sandya Liyanarachchi Qun Pan Blake Bertani Rebecca Nagy David E Symer Benjamin J Blencowe Albert de la Chapelle

Sci Rep 2015 Jul 2;5:10566. Epub 2015 Jul 2.

Department of Molecular Virology, Immunology and Medical Genetics, Ohio State University Wexner Medical Center and Comprehensive Cancer Center, Ohio State University, Columbus, Ohio, United States of America.

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http://dx.doi.org/10.1038/srep10566DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4488885PMC
July 2015

Multiple functional variants in long-range enhancer elements contribute to the risk of SNP rs965513 in thyroid cancer.

Authors:
Huiling He Wei Li Sandya Liyanarachchi Mukund Srinivas Yanqiang Wang Keiko Akagi Yao Wang Dayong Wu Qianben Wang Victor Jin David E Symer Rulong Shen John Phay Rebecca Nagy Albert de la Chapelle

Proc Natl Acad Sci U S A 2015 May 27;112(19):6128-33. Epub 2015 Apr 27.

Human Cancer Genetics Program and Department of Molecular Virology, Immunology, and Medical Genetics,

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http://dx.doi.org/10.1073/pnas.1506255112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4434723PMC
May 2015

Germline and somatic SDHx alterations in apparently sporadic differentiated thyroid cancer.

Authors:
Ying Ni Spencer Seballos Shireen Ganapathi Danielle Gurin Benjamin Fletcher Joanne Ngeow Rebecca Nagy Richard T Kloos Matthew D Ringel Thomas LaFramboise Charis Eng

Endocr Relat Cancer 2015 Apr;22(2):121-30

Genomic Medicine InstituteLerner Research InstituteTaussig Cancer InstituteStanley Shalom Zielony Nursing InstituteCleveland Clinic, 9500 Euclid Avenue, NE-50, Cleveland, Ohio 44195, USADivision of Medical OncologyNational Cancer Center, Singapore 169610, SingaporeDivisions of Human GeneticsEndocrinology and MetabolismDepartment of MedicineComprehensive Cancer CenterArthur G. James Cancer Hospital and Richard G. Solove Research Institute, The Ohio State University, Columbus, Ohio 43210, USADepartments of Genetics and Genome SciencesEpidemiology and BiostatisticsCASE Comprehensive Cancer CenterCase Western Reserve University, Cleveland, Ohio 44116, USA Genomic Medicine InstituteLerner Research InstituteTaussig Cancer InstituteStanley Shalom Zielony Nursing InstituteCleveland Clinic, 9500 Euclid Avenue, NE-50, Cleveland, Ohio 44195, USADivision of Medical OncologyNational Cancer Center, Singapore 169610, SingaporeDivisions of Human GeneticsEndocrinology and MetabolismDepartment of MedicineComprehensive Cancer CenterArthur G. James Cancer Hospital and Richard G. Solove Research Institute, The Ohio State University, Columbus, Ohio 43210, USADepartments of Genetics and Genome SciencesEpidemiology and BiostatisticsCASE Comprehensive Cancer CenterCase Western Reserve University, Cleveland, Ohio 44116, USA Genomic Medicine InstituteLerner Research InstituteTaussig Cancer InstituteStanley Shalom Zielony Nursing InstituteCleveland Clinic, 9500 Euclid Avenue, NE-50, Cleveland, Ohio 44195, USADivision of Medical OncologyNational Cancer Center, Singapore 169610, SingaporeDivisions of Human GeneticsEndocrinology and MetabolismDepartment of MedicineComprehensive Cancer CenterArthur G. James Cancer Hospital and Richard G. Solove Research Institute, The Ohio State University, Columbus, Ohio 43210, USADepartments of Genetics and Genome SciencesEpidemiology and BiostatisticsCASE Comprehensive Cancer CenterCase Western Reserve University, Cleveland, Ohio 44116, USA Genomic Medicine Ins

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http://dx.doi.org/10.1530/ERC-14-0537DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4335266PMC
April 2015

Genetic predisposition for nonmedullary thyroid cancer.

Authors:
Rebecca Nagy Matthew D Ringel

Horm Cancer 2015 Feb 22;6(1):13-20. Epub 2014 Oct 22.

Divison of Human Genetics, The Ohio State University College of Medicine and Arthur G. James Comprehensive Cancer Center and Richard G. Solove Research Institute, Columbus, OH, 43210, USA,

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http://dx.doi.org/10.1007/s12672-014-0205-yDOI Listing
February 2015

Genetic predisposition to papillary thyroid carcinoma: involvement of FOXE1, TSHR, and a novel lincRNA gene, PTCSC2.

Authors:
Huiling He Wei Li Sandya Liyanarachchi Jaroslaw Jendrzejewski Mukund Srinivas Ramana V Davuluri Rebecca Nagy Albert de la Chapelle

J Clin Endocrinol Metab 2015 Jan;100(1):E164-72

Human Cancer Genetics Program and Department of Molecular Virology, Immunology, and Medical Genetics (H.H., W.L., S.L., J.J., M.S., R.N., A.d.l.C), and Department of Internal Medicine (R.N.), Ohio State University Comprehensive Cancer Center, the Ohio State University, Columbus, Ohio 43210; and Division of Health and Biomedical Informatics, Department of Preventive Medicine, Robert H. Lurie Comprehensive Cancer Center (R.V.D.), Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611.

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http://dx.doi.org/10.1210/jc.2014-2147DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4283026PMC
January 2015

Salivary gland cancer in BRCA-positive families: a retrospective review.

Authors:
Tim K Shen Theodoros N Teknos Amanda E Toland Leigha Senter Rebecca Nagy

JAMA Otolaryngol Head Neck Surg 2014 Dec;140(12):1213-7

Division of Human Genetics, Department of Internal Medicine, The Ohio State University Wexner Medical Center, Columbus.

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http://dx.doi.org/10.1001/jamaoto.2014.1998DOI Listing
December 2014

Germline loss-of-function mutations in LZTR1 predispose to an inherited disorder of multiple schwannomas.

Authors:
Arkadiusz Piotrowski Jing Xie Ying F Liu Andrzej B Poplawski Alicia R Gomes Piotr Madanecki Chuanhua Fu Michael R Crowley David K Crossman Linlea Armstrong Dusica Babovic-Vuksanovic Amanda Bergner Jaishri O Blakeley Andrea L Blumenthal Molly S Daniels Howard Feit Kathy Gardner Stephanie Hurst Christine Kobelka Chung Lee Rebecca Nagy Katherine A Rauen John M Slopis Pim Suwannarat Judith A Westman Andrea Zanko Bruce R Korf Ludwine M Messiaen

Nat Genet 2014 Feb 22;46(2):182-7. Epub 2013 Dec 22.

Medical Genomics Laboratory, Department of Genetics, University of Alabama at Birmingham, Birmingham, Alabama, USA.

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http://dx.doi.org/10.1038/ng.2855DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4352302PMC
February 2014

Identification of novel genetic Loci associated with thyroid peroxidase antibodies and clinical thyroid disease.

Authors:
Marco Medici Eleonora Porcu Giorgio Pistis Alexander Teumer Suzanne J Brown Richard A Jensen Rajesh Rawal Greet L Roef Theo S Plantinga Sita H Vermeulen Jari Lahti Matthew J Simmonds Lise Lotte N Husemoen Rachel M Freathy Beverley M Shields Diana Pietzner Rebecca Nagy Linda Broer Layal Chaker Tim I M Korevaar Maria Grazia Plia Cinzia Sala Uwe Völker J Brent Richards Fred C Sweep Christian Gieger Tanguy Corre Eero Kajantie Betina Thuesen Youri E Taes W Edward Visser Andrew T Hattersley Jürgen Kratzsch Alexander Hamilton Wei Li Georg Homuth Monia Lobina Stefano Mariotti Nicole Soranzo Massimiliano Cocca Matthias Nauck Christin Spielhagen Alec Ross Alice Arnold Martijn van de Bunt Sandya Liyanarachchi Margit Heier Hans Jörgen Grabe Corrado Masciullo Tessel E Galesloot Ee M Lim Eva Reischl Peter J Leedman Sandra Lai Alessandro Delitala Alexandra P Bremner David I W Philips John P Beilby Antonella Mulas Matteo Vocale Goncalo Abecasis Tom Forsen Alan James Elisabeth Widen Jennie Hui Holger Prokisch Ernst E Rietzschel Aarno Palotie Peter Feddema Stephen J Fletcher Katharina Schramm Jerome I Rotter Alexander Kluttig Dörte Radke Michela Traglia Gabriela L Surdulescu Huiling He Jayne A Franklyn Daniel Tiller Bijay Vaidya Tim de Meyer Torben Jørgensen Johan G Eriksson Peter C O'Leary Eric Wichmann Ad R Hermus Bruce M Psaty Till Ittermann Albert Hofman Emanuele Bosi David Schlessinger Henri Wallaschofski Nicola Pirastu Yurii S Aulchenko Albert de la Chapelle Romana T Netea-Maier Stephen C L Gough Henriette Meyer Zu Schwabedissen Timothy M Frayling Jean-Marc Kaufman Allan Linneberg Katri Räikkönen Johannes W A Smit Lambertus A Kiemeney Fernando Rivadeneira André G Uitterlinden John P Walsh Christa Meisinger Martin den Heijer Theo J Visser Timothy D Spector Scott G Wilson Henry Völzke Anne Cappola Daniela Toniolo Serena Sanna Silvia Naitza Robin P Peeters

PLoS Genet 2014 Feb 27;10(2):e1004123. Epub 2014 Feb 27.

Department of Internal Medicine, Erasmus Medical Center Rotterdam, Rotterdam, The Netherlands.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3937134PMC
February 2014

Cumulative risk impact of five genetic variants associated with papillary thyroid carcinoma.

Authors:
Sandya Liyanarachchi Anna Wojcicka Wei Li Malgorzata Czetwertynska Elzbieta Stachlewska Rebecca Nagy Kevin Hoag Bernard Wen Rafal Ploski Matthew D Ringel Izabella Kozłowicz-Gudzinska Wojciech Gierlikowski Krystian Jazdzewski Huiling He Albert de la Chapelle

Thyroid 2013 Dec 29;23(12):1532-40. Epub 2013 Aug 29.

1 Human Cancer Genetics Program and Department of Molecular Virology, Immunology, and Medical Genetics, Ohio State University Comprehensive Cancer Center, The Ohio State University , Columbus, Ohio.

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http://dx.doi.org/10.1089/thy.2013.0102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3868253PMC
December 2013

Ultra-rare mutation in long-range enhancer predisposes to thyroid carcinoma with high penetrance.

Authors:
Huiling He Wei Li Dayong Wu Rebecca Nagy Sandya Liyanarachchi Keiko Akagi Jaroslaw Jendrzejewski Hong Jiao Kevin Hoag Bernard Wen Mukund Srinivas Gavisha Waidyaratne Rui Wang Anna Wojcicka Ilene R Lattimer Elzbieta Stachlewska Malgorzata Czetwertynska Joanna Dlugosinska Wojciech Gierlikowski Rafal Ploski Marek Krawczyk Krystian Jazdzewski Juha Kere David E Symer Victor Jin Qianben Wang Albert de la Chapelle

PLoS One 2013 14;8(5):e61920. Epub 2013 May 14.

Department of Molecular Virology, Immunology and Medical Genetics, Ohio State University, Wexner Medical Center and Comprehensive Cancer Center, the Ohio State University, Columbus, Ohio, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3653903PMC
December 2013

Modulation of sodium/iodide symporter expression in the salivary gland.

Authors:
Krista M D La Perle Dong Chul Kim Nathan C Hall Adam Bobbey Daniel H Shen Rebecca S Nagy Paul E Wakely Amy Lehman David Jarjoura Sissy M Jhiang

Thyroid 2013 Aug 17;23(8):1029-36. Epub 2013 Jul 17.

Department of Veterinary Biosciences, The Ohio State University, Columbus, Ohio, USA.

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http://dx.doi.org/10.1089/thy.2012.0571DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3752512PMC
August 2013

SRGAP1 is a candidate gene for papillary thyroid carcinoma susceptibility.

Authors:
Huiling He Agnieszka Bronisz Sandya Liyanarachchi Rebecca Nagy Wei Li Yungui Huang Keiko Akagi Motoyasu Saji Dorota Kula Anna Wojcicka Nikhil Sebastian Bernard Wen Zbigniew Puch Michal Kalemba Elzbieta Stachlewska Malgorzata Czetwertynska Joanna Dlugosinska Kinga Dymecka Rafal Ploski Marek Krawczyk Patrick J Morrison Matthew D Ringel Richard T Kloos Krystian Jazdzewski David E Symer Veronica J Vieland Michael Ostrowski Barbara Jarząb Albert de la Chapelle

J Clin Endocrinol Metab 2013 May 28;98(5):E973-80. Epub 2013 Mar 28.

Human Cancer Genetics Program and Department of Molecular Virology, Immunology, and Medical Genetics, Ohio State University Comprehensive Cancer Center, the Ohio State University, Columbus, Ohio 43210, USA.

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http://dx.doi.org/10.1210/jc.2012-3823DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3644596PMC
May 2013

Introduction.

Authors:
Rebecca Nagy

J Genet Couns 2013 Feb;22(1):1-3

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February 2013

Genetic testing by cancer site: endocrine system.

Authors:
Robert Pilarski Rebecca Nagy

Cancer J 2012 Jul-Aug;18(4):364-71

Clinical Cancer Genetics Program, The Ohio State University, Columbus, OH 43240, USA.

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January 2013

The polymorphism rs944289 predisposes to papillary thyroid carcinoma through a large intergenic noncoding RNA gene of tumor suppressor type.

Authors:
Jaroslaw Jendrzejewski Huiling He Hanna S Radomska Wei Li Jerneja Tomsic Sandya Liyanarachchi Ramana V Davuluri Rebecca Nagy Albert de la Chapelle

Proc Natl Acad Sci U S A 2012 May 14;109(22):8646-51. Epub 2012 May 14.

Human Cancer Genetics Program, Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA.

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http://dx.doi.org/10.1073/pnas.1205654109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3365219PMC
May 2012

Essential elements of genetic cancer risk assessment, counseling, and testing: updated recommendations of the National Society of Genetic Counselors.

Authors:
Bronson D Riley Julie O Culver Cécile Skrzynia Leigha A Senter June A Peters Josephine W Costalas Faith Callif-Daley Sherry C Grumet Katherine S Hunt Rebecca S Nagy Wendy C McKinnon Nancie M Petrucelli Robin L Bennett Angela M Trepanier

J Genet Couns 2012 Apr 2;21(2):151-61. Epub 2011 Dec 2.

Southeast Nebraska Cancer Center, Lincoln, NE, USA.

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http://dx.doi.org/10.1007/s10897-011-9462-xDOI Listing
April 2012

MicroRNA signature in thyroid fine needle aspiration cytology applied to "atypia of undetermined significance" cases.

Authors:
Rulong Shen Sandya Liyanarachchi Wei Li Paul E Wakely Motoyasu Saji Jie Huang Rebecca Nagy Tisha Farrell Matthew D Ringel Albert de la Chapelle Richard T Kloos Huiling He

Thyroid 2012 Jan 2;22(1):9-16. Epub 2011 Dec 2.

Department of Pathology, Arthur G. James Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio 43210, USA.

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http://dx.doi.org/10.1089/thy.2011.0081DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3247703PMC
January 2012

Discovery of common variants associated with low TSH levels and thyroid cancer risk.

Authors:
Julius Gudmundsson Patrick Sulem Daniel F Gudbjartsson Jon G Jonasson Gisli Masson Huiling He Aslaug Jonasdottir Asgeir Sigurdsson Simon N Stacey Hrefna Johannsdottir Hafdis Th Helgadottir Wei Li Rebecca Nagy Matthew D Ringel Richard T Kloos Marieke C H de Visser Theo S Plantinga Martin den Heijer Esperanza Aguillo Angeles Panadero Enrique Prats Almudena Garcia-Castaño Ana De Juan Fernando Rivera G Bragi Walters Hjordis Bjarnason Laufey Tryggvadottir Gudmundur I Eyjolfsson Unnur S Bjornsdottir Hilma Holm Isleifur Olafsson Kristleifur Kristjansson Hoskuldur Kristvinsson Olafur T Magnusson Gudmar Thorleifsson Jeffrey R Gulcher Augustine Kong Lambertus A L M Kiemeney Thorvaldur Jonsson Hannes Hjartarson Jose I Mayordomo Romana T Netea-Maier Albert de la Chapelle Jon Hrafnkelsson Unnur Thorsteinsdottir Thorunn Rafnar Kari Stefansson

Nat Genet 2012 Jan 22;44(3):319-22. Epub 2012 Jan 22.

deCODE Genetics, Reykjavik, Iceland.

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http://dx.doi.org/10.1038/ng.1046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3655412PMC
January 2012

Telomere length and telomerase reverse transcriptase gene copy number in patients with papillary thyroid carcinoma.

Authors:
Jaroslaw Jendrzejewski Jerneja Tomsic Gerard Lozanski Jadwiga Labanowska Huiling He Sandya Liyanarachchi Rebecca Nagy Matthew D Ringel Richard T Kloos Nyla A Heerema Albert de la Chapelle

J Clin Endocrinol Metab 2011 Nov 7;96(11):E1876-80. Epub 2011 Sep 7.

Human Cancer Genetics Program, Comprehensive Cancer Center, The Ohio State University, 804 Biomedical Research Tower 460 West 12th Avenue Columbus, Ohio 43210, USA.

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http://dx.doi.org/10.1210/jc.2011-1643DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3205886PMC
November 2011

Frequency of germline PTEN mutations in differentiated thyroid cancer.

Authors:
Rebecca Nagy Shireen Ganapathi Ilene Comeras Charissa Peterson Mohammed Orloff Kyle Porter Charis Eng Matthew D Ringel Richard T Kloos

Thyroid 2011 May 21;21(5):505-10. Epub 2011 Mar 21.

Division of Human Genetics, The Ohio State University Medical Center and Comprehensive Cancer Center, Columbus, Ohio 43240, USA.

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https://www.liebertpub.com/doi/10.1089/thy.2010.0365
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http://dx.doi.org/10.1089/thy.2010.0365DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3092722PMC
May 2011

Mutations in U4atac snRNA, a component of the minor spliceosome, in the developmental disorder MOPD I.

Authors:
Huiling He Sandya Liyanarachchi Keiko Akagi Rebecca Nagy Jingfeng Li Rosemary C Dietrich Wei Li Nikhil Sebastian Bernard Wen Baozhong Xin Jarnail Singh Pearlly Yan Hansjuerg Alder Eric Haan Dagmar Wieczorek Beate Albrecht Erik Puffenberger Heng Wang Judith A Westman Richard A Padgett David E Symer Albert de la Chapelle

Science 2011 Apr;332(6026):238-40

Human Cancer Genetics Program, Ohio State University, Columbus, OH 43210, USA.

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http://dx.doi.org/10.1126/science.1200587DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3380448PMC
April 2011

Role of PTPRJ genotype in papillary thyroid carcinoma risk.

Authors:
Rodolfo Iuliano Dario Palmieri Huiling He Angela Iervolino Eleonora Borbone Pierlorenzo Pallante Alessandra Cianflone Rebecca Nagy Hansjuerg Alder George A Calin Francesco Trapasso Carla Giordano Carlo M Croce Albert de la Chapelle Alfredo Fusco

Endocr Relat Cancer 2010 Dec 29;17(4):1001-6. Epub 2010 Oct 29.

Dipartimento di Medicina Sperimentale e Clinica, Facoltà di Medicina e Chirurgia, Università degli Studi Magna Græcia di Catanzaro, Campus Salvatore Venuta, Viale Europa, località Germaneto, Catanzaro, Italy.

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https://erc.bioscientifica.com/view/journals/erc/17/4/1001.x
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http://dx.doi.org/10.1677/ERC-10-0143DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3915780PMC
December 2010

The relationship between body mass index and thyroid cancer pathology features and outcomes: a clinicopathological cohort study.

Authors:
John E Paes Keding Hua Rebecca Nagy Richard T Kloos David Jarjoura Matthew D Ringel

J Clin Endocrinol Metab 2010 Sep 2;95(9):4244-50. Epub 2010 Jun 2.

Divisions of Endocrinology, Diabetes, and Metabolism, The Ohio State University College of Medicine and Arthur G. James Comprehensive Cancer Center, Columbus, Ohio 43235, USA.

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http://dx.doi.org/10.1210/jc.2010-0440DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2936072PMC
September 2010

Low cancer incidence rates in Ohio Amish.

Authors:
Judith A Westman Amy K Ferketich Ross M Kauffman Steven N MacEachern J R Wilkins Patricia P Wilcox Robert T Pilarski Rebecca Nagy Stanley Lemeshow Albert de la Chapelle Clara D Bloomfield

Cancer Causes Control 2010 Jan 25;21(1):69-75. Epub 2009 Sep 25.

Division of Human Genetics, The Ohio State University, Columbus, OH, USA.

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http://dx.doi.org/10.1007/s10552-009-9435-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4308689PMC
January 2010

Common variants on 9q22.33 and 14q13.3 predispose to thyroid cancer in European populations.

Authors:
Julius Gudmundsson Patrick Sulem Daniel F Gudbjartsson Jon G Jonasson Asgeir Sigurdsson Jon T Bergthorsson Huiling He Thorarinn Blondal Frank Geller Margret Jakobsdottir Droplaug N Magnusdottir Sigurborg Matthiasdottir Simon N Stacey Oskar B Skarphedinsson Hafdis Helgadottir Wei Li Rebecca Nagy Esperanza Aguillo Eduardo Faure Enrique Prats Berta Saez Mariano Martinez Gudmundur I Eyjolfsson Unnur S Bjornsdottir Hilma Holm Kristleifur Kristjansson Michael L Frigge Hoskuldur Kristvinsson Jeffrey R Gulcher Thorvaldur Jonsson Thorunn Rafnar Hannes Hjartarsson Jose I Mayordomo Albert de la Chapelle Jon Hrafnkelsson Unnur Thorsteinsdottir Augustine Kong Kari Stefansson

Nat Genet 2009 Apr 6;41(4):460-4. Epub 2009 Feb 6.

deCODE Genetics, Sturlugata 8, Reykjavik, Iceland.

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http://www.nature.com/articles/ng.339
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http://dx.doi.org/10.1038/ng.339DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3664837PMC
April 2009

A susceptibility locus for papillary thyroid carcinoma on chromosome 8q24.

Authors:
Huiling He Rebecca Nagy Sandya Liyanarachchi Hong Jiao Wei Li Saul Suster Juha Kere Albert de la Chapelle

Cancer Res 2009 Jan;69(2):625-31

Human Cancer Genetics Program, Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio 43210, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-08-1071DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2634601PMC
January 2009

Taxpayer identification numbers and identity theft.

Authors:
Rebecca Nagy Kristine Tuma

J Mich Dent Assoc 2008 May;90(5):34, 36

Delta Dental of Michigan, MI, USA.

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May 2008

Identification of a novel noncoding RNA gene, NAMA, that is downregulated in papillary thyroid carcinoma with BRAF mutation and associated with growth arrest.

Authors:
Heejei Yoon Huiling He Rebecca Nagy Ramana Davuluri Saul Suster Daniel Schoenberg Natalia Pellegata Albert de la Chapelle

Int J Cancer 2007 Aug;121(4):767-75

Human Cancer Genetics Program, Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA.

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http://dx.doi.org/10.1002/ijc.22701DOI Listing
August 2007

The role of microRNA genes in papillary thyroid carcinoma.

Authors:
Huiling He Krystian Jazdzewski Wei Li Sandya Liyanarachchi Rebecca Nagy Stefano Volinia George A Calin Chang-Gong Liu Kaarle Franssila Saul Suster Richard T Kloos Carlo M Croce Albert de la Chapelle

Proc Natl Acad Sci U S A 2005 Dec 19;102(52):19075-80. Epub 2005 Dec 19.

Human Cancer Genetics Program, Department of Pathology, Ohio State University, Columbus, OH 43210, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.0509603102
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http://dx.doi.org/10.1073/pnas.0509603102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1323209PMC
December 2005

Allelic variation in gene expression in thyroid tissue.

Authors:
Huiling He Katie Olesnanik Rebecca Nagy Sandya Liyanarachchi Manju L Prasad Constantine A Stratakis Richard T Kloos Albert de la Chapelle

Thyroid 2005 Jul;15(7):660-7

Human Cancer Genetics Program, The Ohio State University, Columbus, Ohio 43210, USA.

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http://dx.doi.org/10.1089/thy.2005.15.660DOI Listing
July 2005

Highly penetrant hereditary cancer syndromes.

Authors:
Rebecca Nagy Kevin Sweet Charis Eng

Oncogene 2004 Aug;23(38):6445-70

Clinical Cancer Genetics Program, Comprehensive Cancer Center, Division of Human Genetics, Department of Internal Medicine, The Ohio State University, Columbus 43221, USA.

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http://www.nature.com/articles/1207714
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http://dx.doi.org/10.1038/sj.onc.1207714DOI Listing
August 2004