Rebecca J Dearman

Rebecca J Dearman

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Rebecca J Dearman

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The impact of thioredoxin reduction of allosteric disulfide bonds on the therapeutic potential of monoclonal antibodies.

J Biol Chem 2019 Dec 14;294(51):19616-19634. Epub 2019 Nov 14.

Division of Biotherapeutics, The National Institute for Biological Standards and Control, Blanche Lane, South Mimms, Potters Bar, Hertfordshire EN6 3QG, United Kingdom

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http://dx.doi.org/10.1074/jbc.RA119.010637DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6926469PMC
December 2019

T lymphocyte phenotype of contact-allergic patients: experience with nickel and p-phenylenediamine.

Contact Dermatitis 2019 Jul 8;81(1):43-53. Epub 2019 Apr 8.

Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1111/cod.13246DOI Listing
July 2019

Impact of a Heat Shock Protein Impurity on the Immunogenicity of Biotherapeutic Monoclonal Antibodies.

Pharm Res 2019 Feb 15;36(4):51. Epub 2019 Feb 15.

School of Biological Sciences, Faculty of Biology Medicine and Health Manchester Academic Health Science Centre, The University of Manchester, Michael Smith Building Oxford Road, Manchester, M13 9PT, UK.

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http://link.springer.com/10.1007/s11095-019-2586-7
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http://dx.doi.org/10.1007/s11095-019-2586-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6394513PMC
February 2019

Identification of B cell epitopes enhanced by protein unfolding and aggregation.

Mol Immunol 2019 01 11;105:181-189. Epub 2018 Dec 11.

Lydia Becker Institute of Immunology and Inflammation, School of Biological Sciences, Faculty of Biology, Medicine and Health, Manchester Academic Health Science Centre, The University of Manchester, Oxford Road, Manchester, UK. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01615890183051
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http://dx.doi.org/10.1016/j.molimm.2018.11.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6344229PMC
January 2019

Lower levels of interleukin-1β gene expression are associated with impaired Langerhans' cell migration in aged human skin.

Immunology 2018 01 31;153(1):60-70. Epub 2017 Aug 31.

The Dermatology Centre, Division of Musculoskeletal and Dermatological Sciences, Faculty of Biology Medicine and Health, School of Biological Sciences, Manchester Academic Health Science Centre, The University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1111/imm.12810DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5721243PMC
January 2018

Surrogate CD16-expressing effector cell lines for determining the bioactivity of therapeutic monoclonal antibodies.

J Pharm Biomed Anal 2017 Sep 9;143:188-198. Epub 2017 Jun 9.

Cytokines and Growth Factors Section, Biotherapeutics Group, NIBSC, Blanche Ln, South Mimms, Potters Bar EN6 3QG, UK.

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http://dx.doi.org/10.1016/j.jpba.2017.06.004DOI Listing
September 2017

Investigating Liquid-Liquid Phase Separation of a Monoclonal Antibody Using Solution-State NMR Spectroscopy: Effect of Arg·Glu and Arg·HCl.

Mol Pharm 2017 08 28;14(8):2852-2860. Epub 2017 Jun 28.

Manchester Institute of Biotechnology and School of Chemistry, The University of Manchester , Manchester, M1 7DN, U.K.

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http://dx.doi.org/10.1021/acs.molpharmaceut.7b00418DOI Listing
August 2017

Influence of Escherichia coli chaperone DnaK on protein immunogenicity.

Immunology 2017 03 7;150(3):343-355. Epub 2016 Dec 7.

Faculty of Biology, Medicine and Health, School of Biological Sciences, The University of Manchester, Manchester, UK.

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http://doi.wiley.com/10.1111/imm.12689
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http://dx.doi.org/10.1111/imm.12689DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5290234PMC
March 2017

Editor's Highlight: Subvisible Aggregates of Immunogenic Proteins Promote a Th1-Type Response.

Toxicol Sci 2016 10 30;153(2):258-70. Epub 2016 Jun 30.

*Faculty of Life Sciences, The University of Manchester, C1256, Michael Smith Building, Dover St, Manchester M13 9PT, UK;

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http://dx.doi.org/10.1093/toxsci/kfw121DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5036615PMC
October 2016

Respiratory allergenic potential of plant-derived proteins: Understanding the relationship between exposure and potency for risk assessments.

Crit Rev Toxicol 2015 13;45(9):799-811. Epub 2015 Nov 13.

a The Procter & Gamble Company, Central Product Safety, Mason Business Center , Mason , OH , USA.

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http://dx.doi.org/10.3109/10408444.2015.1067876DOI Listing
September 2016

The lymphocyte transformation test in allergic contact dermatitis: New opportunities.

J Immunotoxicol 2016 6;13(1):84-91. Epub 2015 Feb 6.

a Faculty of Life Sciences , University of Manchester , Manchester , UK .

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http://dx.doi.org/10.3109/1547691X.2015.1008656DOI Listing
August 2016

T lymphocyte dynamics in methylisothiazolinone-allergic patients.

Contact Dermatitis 2016 Jul 3;75(1):1-13. Epub 2016 May 3.

Faculty of Life Sciences, University of Manchester, M13 9PT, Manchester, UK.

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http://dx.doi.org/10.1111/cod.12600DOI Listing
July 2016

Anti-hapten antibodies in response to skin sensitization.

Contact Dermatitis 2016 Apr 11;74(4):197-204. Epub 2015 Nov 11.

Department of Toxicology, Faculty of Life Sciences, University of Manchester, Manchester, M13 9PT, UK.

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http://dx.doi.org/10.1111/cod.12486DOI Listing
April 2016

Evaluation of 5-methylcytosine and 5-hydroxymethylcytosine as potential biomarkers for characterisation of chemical allergens.

Toxicology 2016 Jan 28;340:17-26. Epub 2015 Dec 28.

Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, UK.

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http://dx.doi.org/10.1016/j.tox.2015.12.003DOI Listing
January 2016

Interleukin-1β Processing Is Dependent on a Calcium-mediated Interaction with Calmodulin.

J Biol Chem 2015 Dec 11;290(52):31151-61. Epub 2015 Nov 11.

From the Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, United Kingdom and.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M115.680694
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http://dx.doi.org/10.1074/jbc.M115.680694DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4692238PMC
December 2015

P2X7R activation drives distinct IL-1 responses in dendritic cells compared to macrophages.

Cytokine 2015 Aug 9;74(2):293-304. Epub 2015 Jun 9.

Faculty of Life Sciences, Smith Building, The University of Manchester, UK. Electronic address:

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http://dx.doi.org/10.1016/j.cyto.2015.05.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4504032PMC
August 2015

Chemical allergy in humans: fresh perspectives.

J Immunotoxicol 2014 Jul-Sep;11(3):203-4. Epub 2013 Sep 25.

Faculty of Life Sciences, University of Manchester , Manchester , UK .

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http://dx.doi.org/10.3109/1547691X.2013.833661DOI Listing
April 2015

Immunogenicity of therapeutic proteins: influence of aggregation.

J Immunotoxicol 2014 Apr-Jun;11(2):99-109. Epub 2013 Aug 6.

Faculty of Life Sciences, University of Manchester , Manchester , UK.

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http://www.tandfonline.com/doi/full/10.3109/1547691X.2013.82
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http://dx.doi.org/10.3109/1547691X.2013.821564DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4002659PMC
December 2014

The XS106 cell: a Langerhans' cell surrogate with a selective type 2 phenotype.

Cutan Ocul Toxicol 2014 Dec 18;33(4):303-12. Epub 2014 Mar 18.

The Faculty of Life Sciences, The University of Manchester , Manchester , UK.

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http://dx.doi.org/10.3109/15569527.2013.873046DOI Listing
December 2014

Dendritic cell IL-1α and IL-1β are polyubiquitinated and degraded by the proteasome.

J Biol Chem 2014 Dec 4;289(51):35582-92. Epub 2014 Nov 4.

From the Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, United Kingdom and.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M114.595686
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http://dx.doi.org/10.1074/jbc.M114.595686DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4271241PMC
December 2014

The effect of arginine glutamate on the stability of monoclonal antibodies in solution.

Int J Pharm 2014 Oct 30;473(1-2):126-33. Epub 2014 Jun 30.

Manchester Institute of Biotechnology, University of Manchester, Manchester M1 7DN, UK; Faculty of Life Sciences, University of Manchester, Manchester M13 9PL, UK. Electronic address:

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http://dx.doi.org/10.1016/j.ijpharm.2014.06.053DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4162492PMC
October 2014

Diisocyanates, occupational asthma and IgE antibody: implications for hazard characterization.

J Appl Toxicol 2014 Oct 25;34(10):1073-7. Epub 2014 Jul 25.

Faculty of Life Sciences, University of Manchester, Michael Smith Building, Oxford Road, Manchester, M13 9PT, UK.

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http://doi.wiley.com/10.1002/jat.3041
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http://dx.doi.org/10.1002/jat.3041DOI Listing
October 2014

Characterization of the allergenic potential of proteins: an assessment of the kiwifruit allergen actinidin.

J Appl Toxicol 2014 May 10;34(5):489-97. Epub 2013 Jun 10.

Faculty of Life Sciences, The University of Manchester, Michael Smith Building, Oxford Road, Manchester, M13 9PT, UK.

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http://dx.doi.org/10.1002/jat.2897DOI Listing
May 2014

Chemical respiratory allergy: reverse engineering an adverse outcome pathway.

Toxicology 2014 Apr 15;318:32-9. Epub 2014 Feb 15.

Toxicology and Environmental Research & Consulting, The Dow Chemical Company, Midland, MI, USA.

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http://dx.doi.org/10.1016/j.tox.2014.02.001DOI Listing
April 2014

Treatment-related restoration of Langerhans cell migration in psoriasis.

J Invest Dermatol 2014 Jan 28;134(1):268-271. Epub 2013 Jun 28.

Dermatology Research Centre, University of Manchester, Manchester Academic Health Science Centre, Manchester, UK.

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http://dx.doi.org/10.1038/jid.2013.289DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3898345PMC
January 2014

Danger, intracellular signaling, and the orchestration of dendritic cell function in skin sensitization.

J Immunotoxicol 2013 Jul-Sep;10(3):223-34. Epub 2012 Sep 7.

Faculty of Life Sciences, University of Manchester, Manchester, UK.

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http://dx.doi.org/10.3109/1547691X.2012.711782DOI Listing
November 2013

The selective peptide reactivity of chemical respiratory allergens under competitive and non-competitive conditions.

J Immunotoxicol 2013 Jul-Sep;10(3):292-301. Epub 2012 Oct 10.

Research Institute for Fragrance Materials Inc., Woodcliff Lake, NJ 07677, USA.

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http://dx.doi.org/10.3109/1547691X.2012.725784DOI Listing
November 2013

Relationship between protein digestibility and allergenicity: comparisons of pepsin and cathepsin.

Toxicology 2013 Jul 23;309:30-8. Epub 2013 Apr 23.

Faculty of Life Sciences, The University of Manchester, Michael Smith Building, Oxford Road, Manchester M13 9PT, UK.

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http://dx.doi.org/10.1016/j.tox.2013.04.011DOI Listing
July 2013

Dendritic cells and the assessment in vitro of skin sensitizing potential.

Cutan Ocul Toxicol 2013 Mar 6;32(1):54-9. Epub 2012 Jun 6.

Faculty of Life Sciences, University of Manchester, Manchester, UK.

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http://dx.doi.org/10.3109/15569527.2012.692135DOI Listing
March 2013

Local lymph node assays.

Curr Protoc Toxicol 2004 ;Chapter 18:Unit18.2

Syngenta Central Toxicology Laboratory, Alderley Park, Macclesfield, Cheshire, United Kingdom.

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http://dx.doi.org/10.1002/0471140856.tx1802s20DOI Listing
February 2013

Differential immunogenicity and allergenicity of native and recombinant human lactoferrins: role of glycosylation.

Eur J Immunol 2013 Jan 7;43(1):170-81. Epub 2012 Nov 7.

Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom.

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http://dx.doi.org/10.1002/eji.201142345DOI Listing
January 2013

Regulation of allergic responses to chemicals and drugs: possible roles of epigenetic mechanisms.

Toxicol Sci 2012 Nov 15;130(1):60-9. Epub 2012 Jun 15.

Discovery and Investigative Safety, Novartis Institutes for Biomedical Research, Basel CH-4057, Switzerland.

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http://toxsci.oxfordjournals.org/content/130/1/60.full.pdf
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http://www.toxsci.oxfordjournals.org/cgi/doi/10.1093/toxsci/
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http://dx.doi.org/10.1093/toxsci/kfs207DOI Listing
November 2012

Influence of protein expression system on elicitation of IgE antibody responses: experience with lactoferrin.

Toxicology 2012 Nov 17;301(1-3):50-7. Epub 2012 Jul 17.

The University of Manchester, Manchester M13 9PT, UK.

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http://dx.doi.org/10.1016/j.tox.2012.06.018DOI Listing
November 2012

"Omics" Technologies and the Immune System (a) , (b).

Toxicol Mech Methods 2006 ;16(2-3):101-19

Worldwide Safety Sciences, Pfizer Global Research and Development, San Diego, CA, 92121, USA.

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http://dx.doi.org/10.1080/15376520600558424DOI Listing
October 2012

The direct peptide reactivity assay: selectivity of chemical respiratory allergens.

Toxicol Sci 2012 Oct 19;129(2):421-31. Epub 2012 Jun 19.

The University of Manchester, Manchester M13 9PT, UK.

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http://dx.doi.org/10.1093/toxsci/kfs205DOI Listing
October 2012

Immunoregulation of skin sensitization and regulatory T cells.

Contact Dermatitis 2012 Oct 14;67(4):179-83. Epub 2012 Jul 14.

Faculty of Life Sciences, Toxicology Group, University of Manchester, Manchester M13 9PT, UK.

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http://dx.doi.org/10.1111/j.1600-0536.2012.02148.xDOI Listing
October 2012

Allergic contact dermatitis: a commentary on the relationship between T lymphocytes and skin sensitising potency.

Toxicology 2012 Jan 22;291(1-3):18-24. Epub 2011 Nov 22.

Faculty of Life Sciences, University of Manchester, Michael Smith Building, Oxford Road, Manchester M13 9PT, UK.

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http://dx.doi.org/10.1016/j.tox.2011.11.007DOI Listing
January 2012

Extra domain A-positive fibronectin-positive feedback loops and their association with cutaneous inflammatory disease.

Clin Dermatol 2011 May-Jun;29(3):257-65

Department of Cutaneous Allergy, St John's Institute of Dermatology, St Thomas' Hospital, SE1 7EH London, UK.

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http://dx.doi.org/10.1016/j.clindermatol.2010.11.003DOI Listing
July 2011

Chemical reactivity measurements: potential for characterization of respiratory chemical allergens.

Toxicol In Vitro 2011 Mar 17;25(2):433-45. Epub 2010 Nov 17.

Faculty of Life Sciences, The University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1016/j.tiv.2010.11.007DOI Listing
March 2011

Chemical allergy: translating biology into hazard characterization.

Toxicol Sci 2011 Mar 22;120 Suppl 1:S238-68. Epub 2010 Nov 22.

Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, UK.

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http://toxsci.oxfordjournals.org/content/early/2010/11/21/to
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http://www.toxsci.oxfordjournals.org/cgi/doi/10.1093/toxsci/
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http://dx.doi.org/10.1093/toxsci/kfq346DOI Listing
March 2011

Peanut sensitisation and allergy: influence of early life exposure to peanuts.

Br J Nutr 2010 May 26;103(9):1278-86. Epub 2010 Jan 26.

British Nutrition Foundation, London WC1V 6RQ, UK.

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http://dx.doi.org/10.1017/S000711450999376XDOI Listing
May 2010

An assessment of the ability of phthalates to influence immune and allergic responses.

Toxicology 2010 May 3;271(3):73-82. Epub 2010 Apr 3.

Faculty of Life Sciences, University of Manchester, Michael Smith Building, Oxford Road, Manchester, M13 9PT, UK.

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http://dx.doi.org/10.1016/j.tox.2010.03.020DOI Listing
May 2010

Chemical allergens--what are the issues?

Toxicology 2010 Feb 29;268(3):139-42. Epub 2009 Jul 29.

Faculty of Life Sciences, University of Manchester, Faculty of Life Sciences, Michael Smith Building, Oxford Road, Manchester M13 9PT, UK.

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http://dx.doi.org/10.1016/j.tox.2009.07.015DOI Listing
February 2010

The local lymph node assay and skin sensitization testing.

Methods Mol Biol 2010 ;598:221-31

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http://dx.doi.org/10.1007/978-1-60761-401-2_16DOI Listing
February 2010

The cutaneous biochemical redox barrier: a component of the innate immune defenses against sensitization by highly reactive environmental xenobiotics.

J Immunol 2009 Dec 4;183(11):7576-84. Epub 2009 Nov 4.

Dermatopharmacology Unit, School of Medicine, Level F South Block (825), Southampton General Hospital, Tremona Road, Southampton SO16 6YD, UK.

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http://dx.doi.org/10.4049/jimmunol.0901064DOI Listing
December 2009

Langerhans cell migration: not necessarily always at the center of the skin sensitization universe.

J Invest Dermatol 2009 Aug;129(8):1852-3

Faculty of Life Sciences, University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1038/jid.2009.54DOI Listing
August 2009

Toll-like receptor ligand activation of murine bone marrow-derived dendritic cells.

Immunology 2009 Apr 4;126(4):475-84. Epub 2008 Sep 4.

Faculty of Life Sciences, University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1111/j.1365-2567.2008.02922.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2673360PMC
April 2009

Synergistic effects of chemical insult and toll-like receptor ligands on dendritic cell activation.

Toxicol In Vitro 2008 Dec 23;22(8):1927-34. Epub 2008 Sep 23.

Faculty of Life Sciences, University of Manchester, Michael Smith Building, Oxford Road, Manchester M13 9PT, UK.

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http://dx.doi.org/10.1016/j.tiv.2008.09.012DOI Listing
December 2008

The reduced local lymph node assay: the impact of group size.

J Appl Toxicol 2008 May;28(4):518-23

The Procter & Gamble Company, Cincinnati, OH 45253-8707, USA.

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http://dx.doi.org/10.1002/jat.1303DOI Listing
May 2008

IL-18 is a key proximal mediator of contact hypersensitivity and allergen-induced Langerhans cell migration in murine epidermis.

J Leukoc Biol 2008 Feb 5;83(2):361-7. Epub 2007 Nov 5.

St. John's Institute of Dermatology, King's College London, London, United Kingdom.

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http://dx.doi.org/10.1189/jlb.0604352DOI Listing
February 2008

B220 analysis with the local lymph node assay: proposal for a more flexible prediction model.

J Appl Toxicol 2007 Sep-Oct;27(5):506-10

Syngenta Central Toxicology Laboratory, Alderley Park, Macclesfield, Cheshire SK10 4TJ, UK.

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http://dx.doi.org/10.1002/jat.1269DOI Listing
October 2007

Extrapolating local lymph node assay EC3 values to estimate relative sensitizing potency.

Cutan Ocul Toxicol 2007 ;26(2):135-45

The Procter & Gamble Company. Cincinnati, Ohio, USA.

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http://dx.doi.org/10.1080/15569520701212258DOI Listing
August 2007

Mechanistic applicability domain classification of a local lymph node assay dataset for skin sensitization.

Chem Res Toxicol 2007 Jul 8;20(7):1019-30. Epub 2007 Jun 8.

School of Pharmacy and Chemistry, Liverpool John Moores University, Liverpool, UK.

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http://dx.doi.org/10.1021/tx700024wDOI Listing
July 2007

Local lymph node assay (LLNA) for detection of sensitization capacity of chemicals.

Methods 2007 Jan;41(1):54-60

The Procter & Gamble Company, Central Product Safety Department, Miami Valley Innovation Center, P.O. Box 538707, Cincinnati, OH 45253, USA.

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http://dx.doi.org/10.1016/j.ymeth.2006.07.006DOI Listing
January 2007

A mouse model for food allergy using intraperitoneal sensitization.

Methods 2007 Jan;41(1):91-8

Syngenta Central Toxicology Laboratory, Alderley Park, Macclesfield, Cheshire SK10 4TJ, UK.

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http://dx.doi.org/10.1016/j.ymeth.2006.07.008DOI Listing
January 2007

The IgE-facilitated allergen binding (FAB) assay: validation of a novel flow-cytometric based method for the detection of inhibitory antibody responses.

J Immunol Methods 2006 Dec 5;317(1-2):71-9. Epub 2006 Oct 5.

Upper Respiratory Medicine, Allergy and Clinical Immunology, National Heart and Lung Institute, Faculty of Medicine, Imperial College, Dovehouse Street, London, SW3 6LY, UK.

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http://dx.doi.org/10.1016/j.jim.2006.09.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1934503PMC
December 2006

Skin sensitization potency of methyl methacrylate in the local lymph node assay: comparisons with guinea-pig data and human experience.

Contact Dermatitis 2006 Sep;55(3):140-7

Syngenta Central Toxicology Laboratory, Alderley Park, Macclesfield, Cheshire SK1 4TJ, UK.

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http://doi.wiley.com/10.1111/j.1600-0536.2006.00898.x
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http://dx.doi.org/10.1111/j.1600-0536.2006.00898.xDOI Listing
September 2006

Identification of gene expression changes induced by chemical allergens in dendritic cells: opportunities for skin sensitization testing.

J Invest Dermatol 2006 Aug 27;126(8):1813-22. Epub 2006 Apr 27.

Central Product Safety Department, Miami Valley Innovation Center, The Procter & Gamble Company, Cincinnati, Ohio 45253-8707, USA.

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http://dx.doi.org/10.1038/sj.jid.5700319DOI Listing
August 2006

Impaired Langerhans cell migration in psoriasis.

J Exp Med 2006 Apr 27;203(4):953-60. Epub 2006 Mar 27.

Syngenta Central Toxicology Laboratory, Macclesfield, Cheshire, SK10 4TJ, England, UK.

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http://dx.doi.org/10.1084/jem.20052367DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2118293PMC
April 2006

The local lymph node assay and skin sensitization: a cut-down screen to reduce animal requirements?

Contact Dermatitis 2006 Apr;54(4):181-5

Syngenta Central Toxicology Laboratory, Alderley Park, Macclesfield, Cheshire, UK.

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http://dx.doi.org/10.1111/j.0105-1873.2006.00827.xDOI Listing
April 2006

Compilation of historical local lymph node data for evaluation of skin sensitization alternative methods.

Dermatitis 2005 Dec;16(4):157-202

The Procter & Gamble Company, Miami Valley Innovation Center, P.O. Box 538707, Cincinnati, OH 45253-8707, USA.

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December 2005

Interactions of contact allergens with dendritic cells: opportunities and challenges for the development of novel approaches to hazard assessment.

Toxicol Sci 2005 Nov 13;88(1):4-11. Epub 2005 Jul 13.

Miami Valley Innovation Center, Central Product Safety Department, The Procter & Gamble Company, Cincinnati, Ohio 45253-8707, USA.

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http://dx.doi.org/10.1093/toxsci/kfi245DOI Listing
November 2005

Predictive identification of human skin sensitization thresholds.

Contact Dermatitis 2005 Nov;53(5):260-7

Unilever, Colworth House, Sharnbrook, Bedfordshire, UK.

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http://dx.doi.org/10.1111/j.0105-1873.2005.00707.xDOI Listing
November 2005

Characterisation of immune responses to food allergens in mice.

Proc Nutr Soc 2005 Nov;64(4):426-33

Syngenta Central Toxicology Laboratory, Macclesfield, Cheshire, UK.

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http://dx.doi.org/10.1079/pns2005456DOI Listing
November 2005

Impact of cutaneous IL-10 on resident epidermal Langerhans' cells and the development of polarized immune responses.

J Immunol 2005 Jul;175(1):43-50

Syngenta Central Toxicology Laboratory, Alderley Park, Macclesfield, Cheshire, United Kingdom.

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http://dx.doi.org/10.4049/jimmunol.175.1.43DOI Listing
July 2005

Detection of Allergen-Specific IgE Antibody Responses.

J Immunotoxicol 2005 Jul;1(3):189-99

Syngenta Central Toxicology Laboratory, Cheshire, United Kingdom.

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http://dx.doi.org/10.1080/15476910490919140DOI Listing
July 2005

Potency and risk assessment of a skin-sensitizing disperse dye using the local lymph node assay.

Contact Dermatitis 2005 May;52(5):268-72

Syngenta Central Toxicology Laboratory, Alderley Park, Macclesfield, Cheshire SK1 4TJ, UK.

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http://dx.doi.org/10.1111/j.0105-1873.2005.00578.xDOI Listing
May 2005

What makes a chemical a respiratory sensitizer?

Curr Opin Allergy Clin Immunol 2005 Apr;5(2):119-24

Syngenta Central Toxicology Laboratory, Alderley Park, Macclesfield, Cheshire SK10 4TJ, UK.

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http://dx.doi.org/10.1097/01.all.0000162302.82233.93DOI Listing
April 2005

Selective haptenation of cellular or extracellular protein by chemical allergens: association with cytokine polarization.

Chem Res Toxicol 2005 Feb;18(2):375-81

Department of Pharmacology and Therapeutics, The University of Liverpool, P. O. Box 147, Liverpool L69 3GE, England.

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http://dx.doi.org/10.1021/tx049688+DOI Listing
February 2005

Exposure of mice to the nitroso metabolite of sulfamethoxazole stimulates interleukin 5 production by CD4+ T-cells.

Toxicology 2005 Jan;206(2):221-31

Department of Pharmacology and Therapeutics, The University of Liverpool, Sherrington Building, Ashton Street, P.O. Box 147, Liverpool L69 3BX, UK.

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http://linkinghub.elsevier.com/retrieve/pii/S0300483X0400471
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http://dx.doi.org/10.1016/j.tox.2004.08.010DOI Listing
January 2005

Intradermal exposure of BALB/c strain mice to peanut protein elicits a type 2 cytokine response.

Food Chem Toxicol 2004 Oct;42(10):1589-99

Syngenta Central Toxicology Laboratory, Alderley Park, Macclesfield, Cheshire SK10 4TJ, UK.

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http://dx.doi.org/10.1016/j.fct.2004.05.004DOI Listing
October 2004

Gene expression changes in peripheral blood-derived dendritic cells following exposure to a contact allergen.

Toxicol Lett 2004 May;150(3):301-16

Miami Valley Laboratories, Central Product Safety Department, The Procter & Gamble Company, P.O. Box 538707, Cincinnati, OH 45253, USA.

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http://dx.doi.org/10.1016/j.toxlet.2004.02.002DOI Listing
May 2004

A chemical dataset for evaluation of alternative approaches to skin-sensitization testing.

Contact Dermatitis 2004 May;50(5):274-88

The Procter & Gamble Company, Miami Valley Laboratories, Cincinnati, OH 45253-8707, USA.

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http://dx.doi.org/10.1111/j.0105-1873.2004.00290.xDOI Listing
May 2004

Factors influencing the induction phase of skin sensitization.

Am J Contact Dermat 2003 Dec;14(4):188-94

Syngenta Central Toxicology Laboratory, Alderley Park, Macclesfield, Cheshire SK10 4TJ, UK.

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December 2003

Epidermal Langerhans cell migration and sensitisation to chemical allergens.

APMIS 2003 Jul-Aug;111(7-8):797-804

Syngenta Central Toxicology Laboratory, Alderley Park, Macclesfield, Cheshire and The Dermatology Centre, University of Manchester, Hope Hospital, Salford, Manchester, UK.

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http://dx.doi.org/10.1034/j.1600-0463.2003.11107811.xDOI Listing
October 2003

Assessment of protein allergenicity on the basis of immune reactivity: animal models.

Environ Health Perspect 2003 Jun;111(8):1125-30

Syngenta Central Toxicology Laboratory, Alderley Park, Macclesfield, Cheshire, United Kingdom.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1241562PMC
http://dx.doi.org/10.1289/ehp.5813DOI Listing
June 2003

Assessment of cumulative allergen-activated lymph node cell proliferation using flow cytometry.

Toxicol Sci 2003 May 15;73(1):80-9. Epub 2003 Apr 15.

Syngenta Central Toxicology Laboratory, Alderley Park, Macclesfield, Cheshire, SK10 4TJ, United Kingdom.

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http://dx.doi.org/10.1093/toxsci/kfg056DOI Listing
May 2003

What makes a chemical an allergen?

Ann Allergy Asthma Immunol 2003 May;90(5 Suppl 2):28-31

Syngenta Central Toxicology Laboratory, Alderley Park, Macclesfield, Cheshire, England.

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http://dx.doi.org/10.1016/s1081-1206(10)61645-6DOI Listing
May 2003

Assessment of the allergenic potential of proteins.

Toxicol Lett 2003 Apr;140-141:297-302

Syngenta Central Toxicology Laboratory, Alderley Park, Cheshire SK10 4TJ, Macclesfield, UK.

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http://dx.doi.org/10.1016/s0378-4274(03)00025-0DOI Listing
April 2003

Chemical allergy: considerations for the practical application of cytokine profiling.

Toxicol Sci 2003 Feb;71(2):137-45

Syngenta Central Toxicology Laboratory, Alderley Park, Macclesfield, Cheshire SK10 4TJ, United Kingdom.

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http://dx.doi.org/10.1093/toxsci/71.2.137DOI Listing
February 2003

Assessment of the inherent allergenic potential of proteins in mice.

Environ Health Perspect 2003 Feb;111(2):227-31

Syngenta Central Toxicology Laboratory, Macclesfield, Cheshire, United Kingdom.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1241356PMC
http://dx.doi.org/10.1289/ehp.5703DOI Listing
February 2003

Factors affecting the development of food allergy.

Proc Nutr Soc 2002 Nov;61(4):435-9

Syngenta Central Toxicology Laboratory, Alderley Park, Macclesfield, Cheshire SK10 4TJ, UK.

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http://dx.doi.org/10.1079/pns2002184DOI Listing
November 2002