Raymond W Lam

Raymond W Lam

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Raymond W Lam

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Reduced accuracy accompanied by reduced neural activity during the performance of an emotional conflict task by unmedicated patients with major depression: A CAN-BIND fMRI study.

J Affect Disord 2019 Oct 6;257:765-773. Epub 2019 Jul 6.

Neuroscience Graduate Program, McMaster University, Hamilton, ON, Canada; Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, ON, Canada; Department of Psychology Neuroscience & Behaviour, McMaster University, Hamilton, ON, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jad.2019.07.037DOI Listing
October 2019

Early change in reward and punishment sensitivity as a predictor of response to antidepressant treatment for major depressive disorder: a CAN-BIND-1 report.

Psychol Med 2019 Jul 17;49(10):1629-1638. Epub 2018 Sep 17.

Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health,Toronto, ON,Canada.

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http://dx.doi.org/10.1017/S0033291718002441DOI Listing
July 2019

The Canadian Biomarker Integration Network in Depression (CAN-BIND): magnetic resonance imaging protocols

J Psychiatry Neurosci 2019 07;44(4):223-236

From the Department of Psychiatry, Cumming School of Medicine, University of Calgary, Calgary, Alta., Canada (MacQueen, Hassel, Addington, Sharma); the Rotman Research Institute, Baycrest, and Department of Medical Biophysics, University of Toronto, Toronto, Ont., Canada (Arnott, Zamyadi, Strother); the Department of Psychology, Queen’s University, Kingston, Ont., Canada (Bowie, Harkness, Milev); the Department of Radiology, University of Calgary, Calgary, Alta., Canada (Bray, Lebel); the Alberta Children’s Hospital Research Institute, Calgary, Alta., Canada (Bray, Lebel); the Child and Adolescent Imaging Research (CAIR) Program, Calgary, Alta., Canada (Bray, Lebel); the Department of Psychology, Neuroscience and Behaviour, McMaster University, and St. Joseph’s Healthcare Hamilton, Hamilton, Ont., Canada (Hall); the Krembil Research Institute and Centre for Mental Health, University Health Network, Toronto, Ont., Canada (Downar); the Institute of Medical Science, Faculty of Medicine, University of Toronto, Toronto, Ont., Canada (Downar); the Department of Psychiatry, Faculty of Medicine, University of Toronto, Toronto, Ont., Canada (Downar, Müller, Rizvi, Rotzinger, Kennedy); the Department of Psychiatry, Krembil Research Centre, University Health Network, University of Toronto, Toronto, Ont., Canada (Foster, Rotzinger, Kennedy); the Department of Psychiatry and Behavioural Neurosciences, McMaster University, and St. Joseph’s Healthcare Hamilton, Hamilton, Ont., Canada (Foster, Frey); the Centre for Youth Bipolar Disorder, Sunnybrook Health Sciences Centre, Toronto, Ont., Canada (Goldstein); the Departments of Psychiatry and Pharmacology, Faculty of Medicine, University of Toronto, Toronto, Ont., Canada (Goldstein); the Department of Computer Science, University of Alberta, Edmonton, Alta., Canada (Harris); the University of British Columbia and Vancouver Coastal Health Authority, Vancouver, B.C., Canada (Lam, Vila-Rodriguez); the Department of Psychiatry, Queen’s University and Providence Care Hospital, Kingston, Ont., Canada (Milev, Soares); the Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ont., Canada (Müller); the Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA (Parikh); the Arthur Sommer Rotenberg Suicide and Depression Studies Program, Li Ka Shing Knowledge Institute and St. Michael’s Hospital, Toronto, Ont., Canada (Rizvi); the Institute of Medical Science, Faculty of Medicine, University of Toronto, Toronto, Ont., Canada (Rizvi); the Department of Psychiatry, St. Michael’s Hospital, University of Toronto, Toronto, Ont., Canada (Rotzinger, Soares, Yu); McGill University, Montréal, Que., Canada (Turecki); the Douglas Mental Health University Institute, Frank B. Common, Montréal, Que., Canada (Turecki); and the Keenan Research Centre for Biomedical Science, Li Ka Shing Knowledge Institute, St. Michael’s Hospital, Toronto, Ont., Canada (Kennedy).

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http://dx.doi.org/10.1503/jpn.180036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6606427PMC
July 2019

Cognitive Impairment in Major Depressive Disorder: A Case Discussion Illustrating Impact, Assessment, and Management.

J Clin Psychiatry 2018 Jan/Feb;79(1)

University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.4088/JCP.TK16043PD4CDOI Listing
June 2019

Structural network integrity of the central executive network is associated with the therapeutic effect of rTMS in treatment resistant depression.

Prog Neuropsychopharmacol Biol Psychiatry 2019 06 25;92:217-225. Epub 2019 Jan 25.

Non-Invasive Neurostimulation Therapies (NINET) Laboratory, Department of Psychiatry, University of British Columbia, 2255 Wesbrook Mall, Vancouver, BC V6T 2A1, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.pnpbp.2019.01.012DOI Listing
June 2019

Functional disconnectivity of the hippocampal network and neural correlates of memory impairment in treatment-resistant depression.

J Affect Disord 2019 Jun 29;253:248-256. Epub 2019 Apr 29.

Non-Invasive Neurostimulation Therapies (NINET) Laboratory, Department of Psychiatry, University of British Columbia, 2255 Wesbrook Mall, Vancouver, BC V6T 2A1, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jad.2019.04.096DOI Listing
June 2019

White Matter Indices of Medication Response in Major Depression: A Diffusion Tensor Imaging Study.

Biol Psychiatry Cogn Neurosci Neuroimaging 2019 Jun 12. Epub 2019 Jun 12.

Department of Psychology, Neuroscience & Behavior, McMaster University, Hamilton, Ontario, Canada; Imaging Research Center, St. Joseph's Healthcare Hamilton, Hamilton, Ontario, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.bpsc.2019.05.016DOI Listing
June 2019

Structural brain changes in first episode mania with and without psychosis: Data from the Systematic Treatment Optimization Program for Early Mania (STOP-EM).

World J Biol Psychiatry 2018 8;19(sup2):S30-S40. Epub 2016 Dec 8.

a Department of Psychiatry , University of British Columbia , Vancouver , BC , Canada.

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http://dx.doi.org/10.1080/15622975.2016.1249950DOI Listing
May 2019

Trajectories of Response to Dorsolateral Prefrontal rTMS in Major Depression: A THREE-D Study.

Am J Psychiatry 2019 May 15;176(5):367-375. Epub 2019 Feb 15.

The Temerty Centre for Therapeutic Brain Intervention, Centre for Addiction and Mental Health, Toronto (Kaster, Knyahnytska, Daskalakis, Blumberger); the Department of Psychiatry (Kaster, Downar, Giacobbe, Kennedy, Daskalakis, Blumberger), the Institute of Medical Science (Downar, Giacobbe, Kennedy, Daskalakis, Blumberger), and the Dalla Lana School of Public Health (Thorpe), University of Toronto, Toronto; the MRI-Guided rTMS Clinic, Toronto Western Hospital, Toronto (Downar); the Krembil Research Institute, University Health Network, Toronto (Downar, Kennedy); the Department of Psychiatry, University of British Columbia, Vancouver (Vila-Rodriguez, Lam); the Non-Invasive Neurostimulation Therapies Laboratory, University of British Columbia, Vancouver (Vila-Rodriguez); the Shalvata Mental Health Center, Hod-Hasharon, Israel, and the Sackler School of Medicine, Tel Aviv University, Tel Aviv (Feffer); the Department of Neuropsychiatry, School of Medicine, Keio University, Tokyo (Noda); the Harquail Centre for Neuromodulation, Sunnybrook Health Sciences Centre, Toronto (Giacobbe); and the Li Ka Shing Knowledge Institute, Saint Michael's Hospital, Toronto (Kennedy).

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http://ajp.psychiatryonline.org/doi/10.1176/appi.ajp.2018.18
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http://dx.doi.org/10.1176/appi.ajp.2018.18091096DOI Listing
May 2019

Locating the Site of Neuropathic Pain Using MMP-12-Targeted Magnetic Nanoparticles.

Pain Res Manag 2019;2019:9394715. Epub 2019 Mar 6.

Department of Orthopaedic Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228.

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http://dx.doi.org/10.1155/2019/9394715DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6431387PMC
May 2019

Reduced accuracy accompanied by reduced neural activity during the performance of an emotional conflict task by unmedicated patients with major depression: A CAN-BIND fMRI study.

J Affect Disord 2019 Oct 6;257:765-773. Epub 2019 Jul 6.

Neuroscience Graduate Program, McMaster University, Hamilton, ON, Canada; Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, ON, Canada; Department of Psychology Neuroscience & Behaviour, McMaster University, Hamilton, ON, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jad.2019.07.037DOI Listing
October 2019

Cognitive Impairment in Patients With Depression: Awareness, Assessment, and Management.

J Clin Psychiatry 2017 Nov/Dec;78(9):1383-1394

Mood Disorders Psychopharmacology Unit, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.4088/JCP.tk16043ah5cDOI Listing
April 2019

Impact of Cognitive Impairment on Functioning in Patients With Depression.

Authors:
Raymond W Lam

J Clin Psychiatry 2017 Nov/Dec;78(9):e1430

University of British Columbia and Mood Disorders Centre, Djavad Mowafaghian Centre for Brain Health, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.4088/JCP.tk16043tx1cDOI Listing
April 2019

Risperidone adjunctive therapy duration in the maintenance treatment of bipolar I disorder: A post hoc analysis.

J Affect Disord 2019 03 5;246:861-866. Epub 2019 Jan 5.

Department of Psychiatry, University of British Columbia; Mood Disorders Centre of Excellence, University of British Columbia, 2255, Wesbrook Mall, Vancouver, BC V6T 2A1, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jad.2019.01.003DOI Listing
March 2019

Weight gain as a predictor of frontal and temporal lobe volume loss in bipolar disorder: A prospective MRI study.

Bipolar Disord 2019 02 1;21(1):50-60. Epub 2018 Dec 1.

Mood Disorders Centre, University of British Columbia, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1111/bdi.12722DOI Listing
February 2019

Relationship between work functioning and self-reported cognitive complaints in patients with major depressive disorder treated with desvenlafaxine.

Psychiatry Res 2019 02 10;272:144-148. Epub 2018 Dec 10.

Department of Psychiatry, University of British Columbia, Mood Disorders Centre of Excellence, Djavad Mowafaghian Centre for Brain Health, Vancouver, British Columbia, Canada. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01651781183132
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http://dx.doi.org/10.1016/j.psychres.2018.12.062DOI Listing
February 2019

Discrepancy between objective and subjective cognition in major depressive disorder.

Eur Neuropsychopharmacol 2019 01 28;29(1):46-56. Epub 2018 Nov 28.

Mental Health Department, Neuroscience and Mental Health Research Area, Parc Taulí Hospital Universitari, Institut d'Investigació i Innovació Parc Taulí I3PT, Universitat Autònoma de Barcelona, CIBERSAM, Corporació Sanitària Parc Taulí, Sabadell, Barcelona, Spain. Electronic address:

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http://dx.doi.org/10.1016/j.euroneuro.2018.11.1104DOI Listing
January 2019

Inclusion of mental health in global economic development.

BJPsych Int 2018 Nov;15(4):74-76

Department of Psychiatry, University of British Columbia, Vancouver, Canada.

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https://www.cambridge.org/core/product/identifier/S205647401
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http://dx.doi.org/10.1192/bji.2017.23DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6277955PMC
November 2018

The association of duration and severity of disease with executive function: Differences between drug-naïve patients with bipolar and unipolar depression.

J Affect Disord 2018 10 29;238:412-417. Epub 2018 May 29.

Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine Shanghai 200030, PR China.; CAS Center for Excellence in Brain Science and Intelligence Technology, Shanghai 200030, PR China.; Shanghai Key Laboratory of Psychotic disorders, Shanghai 200030, PR China.. Electronic address:

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http://dx.doi.org/10.1016/j.jad.2018.05.051DOI Listing
October 2018

Evidence for the Efficacy of Bright Light Therapy for Bipolar Depression.

Am J Psychiatry 2018 09;175(9):905-906

From the Psychiatry and Clinical Psychobiology Unit, Division of Neuroscience, San Raffaele Scientific Institute, Milan, Italy; Psychiatric Medicine Associates, the Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle; the Department of Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Dresden, Germany; the Department of Psychiatry and Human Behavior, School of Medicine, University of California, Irvine; the Department of Psychiatry, School of Medicine, Trakya University, Edirne, Turkey; the Department of Psychiatry and Psychology, Faculty of Medicine and Surgery, Catholic University of the Sacred Heart, Rome; the Department of Psychiatry, School of Medicine, Vita-Salute San Raffaele University, Milan, Italy; the Section for Psychiatry, Department of Clinical Medicine, University of Bergen, Bergen, and the Division of Mental Health Care, Valen Hospital, Fonna Local Health Authority, Norway; the Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna; the Department of Psychiatry, Shiga University of Medical Science, Otsu, Japan; the Department of Psychiatry, University of British Columbia, Vancouver, Canada; Psychiatric Center Copenhagen, Rigshospitalet, Copenhagen University Hospital, Copenhagen; University Center for Psychiatry, University Medical Center, Groningen, the Netherlands; the Departments of Psychophysiology and of Adult Mental Health, National Institute of Mental Health, National Center of Neurology and Psychiatry, Tokyo; Psychiatrist Team Alkmaar West, Alkmaar, the Netherlands; the Department of Psychiatry, Nihon University School of Medicine, Tokyo; the Department of Affective Disorders, Institute of Psychiatry and Neurology, Warsaw; Maudsley Hospital and the Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London; the Department of Psychiatry, Marmara University Hospital, Istanbul, Turkey; and the Institute of Mental Health, Peking University, Beijing.

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http://dx.doi.org/10.1176/appi.ajp.2018.18020231DOI Listing
September 2018

Monitoring for antidepressant-associated adverse events in the treatment of patients with major depressive disorder: An international consensus statement.

World J Biol Psychiatry 2018 08 6;19(5):330-348. Epub 2017 Oct 6.

a School of Medicine, Barwon Health , Deakin University, IMPACT SRC (Innovation in Mental and Physical Health and Clinical Treatment - Strategic Research Centre) , Geelong , Australia.

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http://dx.doi.org/10.1080/15622975.2017.1379609DOI Listing
August 2018

Appetitive Symptoms Differentially Predict Treatment Response to Fluoxetine, Light, and Placebo in Nonseasonal Major Depression.

J Clin Psychiatry 2018 07 24;79(4). Epub 2018 Jul 24.

Department of Psychiatry, University of British Columbia; Mood Disorders Centre, Djavad Mowafaghian Centre for Brain Health, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.4088/JCP.17m11856DOI Listing
July 2018

Use of Placebo in Clinical Trials of Psychotropic Medication.

Can J Psychiatry 2018 05;63(5):338-341

5 Professor and BC Leadership Chair in Depression Research, Department of Psychiatry, University of British Columbia; Director, Mood Disorders Centre, Djavad Mowafaghian Centre for Brain Health, Vancouver, British Columbia.

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http://dx.doi.org/10.1177/0706743717752917DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5912304PMC
May 2018

Abnormal Functional Connectivity of Frontopolar Subregions in Treatment-Nonresponsive Major Depressive Disorder.

Biol Psychiatry Cogn Neurosci Neuroimaging 2018 04 27;3(4):337-347. Epub 2017 Dec 27.

Krembil Research Institute, University Health Network, Toronto, Canada; MRI-Guided rTMS Clinic, University Health Network, Toronto, Canada; Institute of Medical Science, University of Toronto, Toronto, Canada; Department of Psychiatry, Faculty of Medicine, University of Toronto, Toronto, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.bpsc.2017.12.003DOI Listing
April 2018

Effectiveness of theta burst versus high-frequency repetitive transcranial magnetic stimulation in patients with depression (THREE-D): a randomised non-inferiority trial.

Lancet 2018 04 26;391(10131):1683-1692. Epub 2018 Apr 26.

Department of Psychiatry, University of Toronto, Toronto, ON, Canada; Institute of Medical Science, University of Toronto, Toronto, ON, Canada; Centre for Mental Health, University Health Network, Toronto, ON, Canada; MRI-Guided rTMS Clinic, University Health Network, Toronto, ON, Canada; Krembil Research Institute, University Health Network, Toronto, ON, Canada.

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https://linkinghub.elsevier.com/retrieve/pii/S01406736183029
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http://dx.doi.org/10.1016/S0140-6736(18)30295-2DOI Listing
April 2018

Implications of Cannabis Legalization on Youth and Young Adults.

Can J Psychiatry 2018 01;63(1):65-71

6 Professor, Department of Psychiatry and Adjunct Professor, Department of Medical Genetics, University of Alberta.

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http://dx.doi.org/10.1177/0706743718759031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5788125PMC
January 2018

Subcortical structural volumes in recently remitted first episode mania.

J Affect Disord 2017 11 24;222:23-27. Epub 2017 Jun 24.

Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada.

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http://dx.doi.org/10.1016/j.jad.2017.06.051DOI Listing
November 2017

The impact of fatigue and energy on work functioning and impairment in patients with major depressive disorder treated with desvenlafaxine.

Int Clin Psychopharmacol 2017 11;32(6):343-349

aDepartment of Psychiatry, University of British Columbia bMood Disorders Centre of Excellence, Djavad Mowafaghian Centre for Brain Health, Vancouver, British Columbia, Canada cDepartment of Physical Medicine and Rehabilitation, Harvard Medical School, and Home Base, a Red Sox Foundation and Massachusetts General Hospital Program, Boston, Massachusetts, USA.

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http://Insights.ovid.com/crossref?an=00004850-201711000-0000
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http://dx.doi.org/10.1097/YIC.0000000000000192DOI Listing
November 2017

A sparse representation-based method for parcellation of the resting brain and its application to treatment-resistant major depressive disorder.

J Neurosci Methods 2017 Oct 22;290:57-68. Epub 2017 Jul 22.

Non-Invasive Neurostimulation Therapies (NINET) Laboratory, Department of Psychiatry, University of British Columbia, 2255 Wesbrook Mall, Vancouver, BC V6T 2A1, Canada.

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https://linkinghub.elsevier.com/retrieve/pii/S01650270173026
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http://dx.doi.org/10.1016/j.jneumeth.2017.07.017DOI Listing
October 2017

The Efficacy of Psychostimulants in Major Depressive Episodes: A Systematic Review and Meta-Analysis.

J Clin Psychopharmacol 2017 Aug;37(4):412-418

From the *Mood Disorder Psychopharmacology Unit, University Health Network; †Brain and Cognition Discovery Foundation, ‡Department of Psychiatry, §Department of Pharmacology, and ∥Institute of Medical Science, University of Toronto, Toronto, ON, Canada; ¶Department of Psychiatry, University of Saskatchewan, Saskatoon, SK, Canada; #Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada; and **Department of Neuropsychiatry and Behavioral Science, University of South Carolina School of Medicine, Columbia, SC.

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http://dx.doi.org/10.1097/JCP.0000000000000723DOI Listing
August 2017

Adjunctive ketamine in electroconvulsive therapy: updated systematic review and meta-analysis.

Br J Psychiatry 2017 06 6;210(6):403-407. Epub 2017 Apr 6.

Alexander McGirr, MD, MSc, Department of Psychiatry, University of British Columbia, Vancouver; Marcelo T. Berlim, MD, MSc, Neuromodulation Research Clinic, Depressive Disorders Program, Douglas Mental Health University Institute and McGill University, Montréal, Québec, Canada; David J. Bond, MD, PhD, Department of Psychiatry, University of Minnesota, Minneapolis, USA; Peter Y. Chan, MD, Department of Psychiatry, University of British Columbia, and Neurostimulation Service, Vancouver General Hospital, Vancouver; Lakshmi N. Yatham, MBBS, Raymond W. Lam, MD, Department of Psychiatry and Mood Disorders Centre of Excellence, University of British Columbia, Vancouver, Canada.

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http://dx.doi.org/10.1192/bjp.bp.116.195826DOI Listing
June 2017

A Longitudinal Study of the Relationships Between Mood Symptoms, Body Mass Index, and Serum Adipokines in Bipolar Disorder.

J Clin Psychiatry 2017 Apr;78(4):441-448

Department of Psychiatry, University of British Columbia, Room 2C7-2255 Wesbrook Mall, Vancouver, BC, Canada V6T 2A1.

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http://dx.doi.org/10.4088/JCP.15m10189DOI Listing
April 2017

Lurasidone versus treatment as usual for cognitive impairment in euthymic patients with bipolar I disorder: a randomised, open-label, pilot study.

Lancet Psychiatry 2017 03 7;4(3):208-217. Epub 2017 Feb 7.

Mood Disorders Centre of Excellence, University of British Columbia, Vancouver, BC, Canada.

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http://dx.doi.org/10.1016/S2215-0366(17)30046-9DOI Listing
March 2017

The effect of remission status on work functioning in employed patients treated for major depressive disorder.

Ann Clin Psychiatry 2017 02;29(1):11-16

Department of Psychiatry, University of British Columbia, Vancouver, British Columbia, Canada.

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February 2017

Trajectories of body mass index change in first episode of mania: 3-year data from the Systematic Treatment Optimization Program for Early Mania (STOP-EM).

J Affect Disord 2017 Jan 11;208:291-297. Epub 2016 Oct 11.

Mood Disorders Centre of Excellence, University of British Columbia, 2255, Wesbrook Mall, Vancouver, BC, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jad.2016.08.048DOI Listing
January 2017

Safety and efficacy of adjunctive second-generation antidepressant therapy with a mood stabiliser or an atypical antipsychotic in acute bipolar depression: a systematic review and meta-analysis of randomised placebo-controlled trials.

Lancet Psychiatry 2016 12 26;3(12):1138-1146. Epub 2016 Oct 26.

Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada; Mood Disorders Centre of Excellence, University of British Columbia, Vancouver, BC, Canada. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22150366163026
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http://dx.doi.org/10.1016/S2215-0366(16)30264-4DOI Listing
December 2016

The effects of desvenlafaxine on neurocognitive and work functioning in employed outpatients with major depressive disorder.

J Affect Disord 2016 Oct 31;203:55-61. Epub 2016 May 31.

Department of Psychiatry, University of British Columbia, Mood Disorders Centre of Excellence, Djavad Mowafaghian Centre for Brain Health, Canada.

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http://dx.doi.org/10.1016/j.jad.2016.05.074DOI Listing
October 2016

S-adenosyl methionine (SAMe) for depression in adults.

Cochrane Database Syst Rev 2016 Oct 10;10:CD011286. Epub 2016 Oct 10.

Centre for Affective Disorders, King's College London, Institute of Psychiatry, De Crespigny Park, London, UK, SE5 8AF.

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http://dx.doi.org/10.1002/14651858.CD011286.pub2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6457972PMC
October 2016

The Depression Inventory Development Workgroup: A Collaborative, Empirically Driven Initiative to Develop a New Assessment Tool for Major Depressive Disorder.

Innov Clin Neurosci 2016 Sep-Oct;13(9-10):20-31. Epub 2016 Oct 1.

Dr. Vaccarino is with Indoc Research, Toronto, Ontario, Canada; Dr. Evans is with Indoc Research, Toronto, Ontario, Canada, and Department of Pathology and Molecular Medicine, Queen's University, Kingston, Ontario, Canada; Dr. Kalali is with Quintiles Inc, San Diego, California, USA, and Department of Psychiatry, University of California, San Diego, California, USA; Drs. Kennedy and Placenza are with University Health Network, Toronto, Ontario, Canada; Dr. Engelhardt is with Cronos Clinical Consulting Services, Lambertville, New Jersey, USA; Dr. Frey is with Department of Psychiatry and Behavioural Neurosciences, McMaster University, Hamilton, Ontario, Canada, and Mood Disorders Program and Women's Health Concerns Clinic, St. Joseph's Healthcare, Hamilton, Ontario, Canada; Dr. Greist is with Department of Psychiatry, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA; Dr. Kobak is with Center for Telepsychology, Madison, Wisconsin, USA; Dr. Lam is with Department of Psychiatry, University of British Columbia, Vancouver, British Columbia, Canada; Dr. MacQueen is with Mathison Centre for Mental Health Research and Education, Department of Psychiatry, University of Calgary, Calgary, Alberta, Canada; Dr. Milev is with Department of Psychiatry, Queen's University, Kingston, Ontario, Canada; Dr. Ravindran is with Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada, and Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada; Dr. Sheehan is with Department of Psychiatry and Behavioral Health, University of South Florida College of Medicine, Tampa, Florida, USA; Dr. Sills was with OCBN, Toronto, Ontario, Canada; Dr. Williams is with Columbia University, New York, New York, USA, and Medavante Inc., Trenton, New Jersey, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5141593PMC
October 2016

Heparin-Based Polyelectrolyte Complex Enhances the Therapeutic Efficacy of Bone Morphogenetic Protein-2 for Posterolateral Fusion in a Large Animal Model.

Spine (Phila Pa 1976) 2016 Aug;41(15):1199-207

*Department of Orthopaedic Surgery, Yong Loo Lin School of Medicine, National University of Singapore †Institute of Medical Biology ‡Singapore Bioimaging Consortium §Institute of Materials Research and Engineering, A*STAR ¶Department of Bioengineering, Faculty of Engineering, National University of Singapore.

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http://dx.doi.org/10.1097/BRS.0000000000001543DOI Listing
August 2016

Selection of cognitive tests for trials of therapeutic agents.

Lancet Psychiatry 2016 06;3(6):499

Mood Disorders Psychopharmacology Unit, Toronto Western Hospital, Toronto, ON, Canada.

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http://dx.doi.org/10.1016/S2215-0366(16)30067-0DOI Listing
June 2016

Sinus Tachycardia Induced by Methocarbamol and Repetitive Transcranial Magnetic Stimulation (rTMS).

Brain Stimul 2016 Jan-Feb;9(1):156-8. Epub 2015 Nov 24.

Non-Invasive Neurostimulation Therapies Lab at UBC, Department of Psychiatry, University of British Columbia, Vancouver, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.brs.2015.10.012DOI Listing
May 2016

The Effects of Newer Antidepressants on Occupational Impairment in Major Depressive Disorder: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

CNS Drugs 2016 May;30(5):405-17

Department of Psychiatry, University of British Columbia, 2255 Wesbrook Mall, Vancouver, BC, V6T 2A1, Canada.

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http://dx.doi.org/10.1007/s40263-016-0334-7DOI Listing
May 2016

Ketamine: stimulating antidepressant treatment?

BJPsych Open 2016 May 11;2(3):e5-e9. Epub 2016 May 11.

, MD, Professor and Chairman of the Department of Psychiatry & Behavioural Sciences at the University of New Mexico, Albuquerque, NM, USA.

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http://dx.doi.org/10.1192/bjpo.bp.116.002923DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4995167PMC
May 2016

Association of peripheral inflammation with body mass index and depressive relapse in bipolar disorder.

Psychoneuroendocrinology 2016 Mar 18;65:76-83. Epub 2015 Dec 18.

Mood Disorders Centre, University of British Columbia, 2255 Wesbrook Mall, Vancouver, BC V6T 2A1, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.psyneuen.2015.12.012DOI Listing
March 2016

Relationship between body mass index and hippocampal glutamate/glutamine in bipolar disorder.

Br J Psychiatry 2016 Feb 19;208(2):146-52. Epub 2015 Nov 19.

David J. Bond, MD, PhD, Mood Disorders Centre, University of British Columbia, Vancouver, Canada and Department of Psychiatry, University of Minnesota, Minneapolis, USA; Leonardo Evangelista da Silveira, MD, Mood Disorders Centre, University of British Columbia, Vancouver, Canada, Laboratory of Molecular Psychiatry, Centro de Pesquisas Experimentais, Hospital de Clínicas de Porto Alegre, Porto Alegre and INCT for Translational Medicine, Porto Alegre, Brazil; Erin L. MacMillan, PhD, Department of Medicine (Neurology), University of British Columbia, Vancouver, Canada; Ivan J. Torres, PhD, Mood Disorders Centre, University of British Columbia, Vancouver, Canada; Donna J. Lang, PhD, Wayne Su, MSc, William G. Honer, MD, Centre for Complex Disorders, University of British Columbia, Vancouver, Canada; Raymond W. Lam, MD, Lakshmi N. Yatham, MBBS, Mood Disorders Centre, University of British Columbia, Vancouver, Canada

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http://dx.doi.org/10.1192/bjp.bp.115.163360DOI Listing
February 2016

Efficacy of Bright Light Treatment, Fluoxetine, and the Combination in Patients With Nonseasonal Major Depressive Disorder: A Randomized Clinical Trial.

JAMA Psychiatry 2016 Jan;73(1):56-63

Department of Psychiatry, University of British Columbia, Vancouver, British Columbia, Canada2Mood Disorders Centre, Djavad Mowafaghian Centre for Brain Health, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.1001/jamapsychiatry.2015.2235DOI Listing
January 2016

Enhanced inflammatory and T-helper-1 type responses but suppressed lymphocyte proliferation in patients with seasonal affective disorder and treated by light therapy.

J Affect Disord 2015 Oct 17;185:90-6. Epub 2015 Jun 17.

Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jad.2015.06.003DOI Listing
October 2015

Recovery and recurrence following a first episode of mania: a systematic review and meta-analysis of prospectively characterized cohorts.

J Clin Psychiatry 2015 Sep;76(9):1241-8

Mood Disorders Centre of Excellence, University of British Columbia, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.4088/JCP.14r09245DOI Listing
September 2015

Verbal memory impairment in new onset bipolar disorder: Relationship with frontal and medial temporal morphology.

World J Biol Psychiatry 2015 Jun 24;16(4):249-60. Epub 2015 Feb 24.

Department of Psychiatry, University of British Columbia , Vancouver, BC , Canada.

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http://dx.doi.org/10.3109/15622975.2014.1000373DOI Listing
June 2015

Canadian Network for Mood and Anxiety Treatments (CANMAT) consensus recommendations for functional outcomes in major depressive disorder.

Ann Clin Psychiatry 2015 May;27(2):142-9

Department of Psychiatry, University of British Columbia, Vancouver, British Columbia, Canada. E-mail:

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May 2015

Course and outcome following a first episode of mania: four-year prospective data from the Systematic Treatment Optimization Program (STOP-EM).

J Affect Disord 2015 Apr 22;175:411-7. Epub 2015 Jan 22.

Mood Disorders Centre of Excellence, University of British Columbia, Vancouver, BC, Canada; Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.jad.2015.01.032DOI Listing
April 2015

A systematic review and meta-analysis of randomized controlled trials of adjunctive ketamine in electroconvulsive therapy: efficacy and tolerability.

J Psychiatr Res 2015 Mar 26;62:23-30. Epub 2015 Jan 26.

Department of Psychiatry, University of British Columbia, Vancouver, BC, Canada; Mood Disorders Centre of Excellence, University of British Columbia, Vancouver, BC, Canada.

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March 2015

The relationship between burnout and depressive symptoms in patients with depressive disorders.

J Affect Disord 2015 Feb 22;172:361-6. Epub 2014 Oct 22.

Department of Psychiatry, University of British Columbia, 2255 Wesbrook Mall, Vancouver, BC, Canada V6T 2A1. Electronic address:

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http://dx.doi.org/10.1016/j.jad.2014.10.029DOI Listing
February 2015

STAR*D and Measurement-Based Care for Depression: Don't Toss Out the Baby!

Can J Psychiatry 2015 Jan;60(1):6-8

Professor, Department of Psychiatry, University of Toronto, Toronto, Ontario.

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http://dx.doi.org/10.1177/070674371506000103DOI Listing
January 2015

The relationship between neurocognitive and psychosocial functioning in major depressive disorder: a systematic review.

J Clin Psychiatry 2014 Dec;75(12):1359-70

Mood and Anxiety Disorders Program, Department of Psychiatry, University of British Columbia, Vancouver, British Columbia, Canada.

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http://dx.doi.org/10.4088/JCP.13r08939DOI Listing
December 2014

Predictors of functional improvement in employed adults with major depressive disorder treated with desvenlafaxine.

Int Clin Psychopharmacol 2014 Sep;29(5):239-51

aDepartment of Psychiatry, University of British Columbia, Vancouver, British Columbia bPfizer Canada Inc., Kirkland, Quebec, Canada cDepartment of Psychiatry, Columbia University, New York, New York dPfizer Inc., Groton, Connecticut ePfizer Inc., Collegeville fCGP Strategic Solutions, LLC, Lansdale, Pennsylvania, USA.

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http://dx.doi.org/10.1097/YIC.0000000000000031DOI Listing
September 2014

Body mass index-related regional gray and white matter volume reductions in first-episode mania patients.

Biol Psychiatry 2014 Jul 9;76(2):138-45. Epub 2013 Oct 9.

Mood Disorders Centre (DJB, IJT, RWL, LNY), Department of Psychiatry, University of British Columbia, Vancouver, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.biopsych.2013.08.030DOI Listing
July 2014

Early switching strategies in antidepressant non-responders: current evidence and future research directions.

CNS Drugs 2014 Jul;28(7):601-9

Department of Psychiatry, University of Toronto, Toronto, ON, Canada.

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http://dx.doi.org/10.1007/s40263-014-0171-5DOI Listing
July 2014

Cognitive change in the year after a first manic episode: association between clinical outcome and cognitive performance early in the course of bipolar I disorder.

J Clin Psychiatry 2014 Jun;75(6):e587-93

Department of Psychiatry, University of British Columbia, Room 2C7-2255 Wesbrook Mall, Vancouver, BC, Canada V6T 2A1

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http://dx.doi.org/10.4088/JCP.13m08928DOI Listing
June 2014

Do the symptoms of bipolar disorder really show seasonal variation?

Bipolar Disord 2013 Nov 12;15(7):808-10. Epub 2013 Aug 12.

Psychological Sciences and Statistics, Swinburne University of Technology, Hawthorn, Vic., Australia.

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http://dx.doi.org/10.1111/bdi.12111DOI Listing
November 2013

Effects of combined pharmacotherapy and psychotherapy for improving work functioning in major depressive disorder.

Br J Psychiatry 2013 Nov 12;203(5):358-65. Epub 2013 Sep 12.

Raymond W. Lam, MD, Department of Psychiatry, University of British Columbia, UBC Hospital, Vancouver, British Columbia; Sagar V. Parikh, MD, Department of Psychiatry, University of Toronto, University Health Network, Toronto, Ontario; Rajamannar Ramasubbu, MD, Department of Psychiatry, University of Calgary, Calgary, Alberta; Erin E. Michalak, PhD, Edwin M. Tam, MD, Auby Axler, MD, Lakshmi N. Yatham, MBBS, Department of Psychiatry, University of British Columbia, UBC Hospital, Vancouver, British Columbia; Sidney H. Kennedy, MD, Department of Psychiatry, University of Toronto, University Health Network, Toronto, Ontario; Chinnapalli V. Manjunath, MD, Department of Psychiatry, University of British Columbia, Surrey Memorial Hospital, Surrey, British Columbia, Canada.

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http://dx.doi.org/10.1192/bjp.bp.112.125237DOI Listing
November 2013

Author response.

Authors:
Raymond W Lam

J Psychiatry Neurosci 2013 Jul;38(4):E11-2

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http://dx.doi.org/10.1503/jpn.130055DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3692727PMC
July 2013