Publications

Benefits of Direct-Acting Antivirals for Hepatitis C.
Ann Intern Med 2017 Dec 17;167(11):812-813. Epub 2017 Oct 17.
From University of Michigan, Ann Arbor, Michigan; Massachusetts General Hospital, Boston, Massachusetts; Mayo Clinic, Phoenix, Arizona; Duke University School of Medicine, Durham, North Carolina; and Washington University School of Medicine, St. Louis, Missouri.



Coffee consumption is not associated with prevalent subclinical cardiovascular disease (CVD) or the risk of CVD events, in nonalcoholic fatty liver disease: results from the multi-ethnic study of atherosclerosis.
Metabolism 2017 Oct 24;75:1-5. Epub 2017 Jun 24.
Los Angeles Biomedical Research Institute, Division of Cardiology, Harbor-UCLA Medical Center, Los Angeles, CA, United States. Electronic address:


Cost Effectiveness of Pre- vs Post-Liver Transplant Hepatitis C Treatment With Direct-Acting Antivirals.
Clin Gastroenterol Hepatol 2017 Jun 17. Epub 2017 Jun 17.
Institute for Technology Assessment, Massachusetts General Hospital, Boston, Massachusetts; Harvard Medical School, Boston, Massachusetts; Liver Center and Gastrointestinal Division, Massachusetts General Hospital, Boston, Massachusetts. Electronic address:

Cost-Effectiveness of Risk Score-Stratified Hepatocellular Carcinoma Screening in Patients with Cirrhosis.
Clin Transl Gastroenterol 2017 Jun 22;8(6):e101. Epub 2017 Jun 22.
Division of Liver Diseases, Department of Medicine, Liver Cancer Program, Tisch Cancer Institute, Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.

Relations of Liver Fat With Prevalent and Incident Atrial Fibrillation in the Framingham Heart Study.
J Am Heart Assoc 2017 May 2;6(5). Epub 2017 May 2.
National Heart, Lung, and Blood Institute's and Boston University's Framingham Heart Study, Framingham, MA.





Apolipoprotein B100 is required for hepatitis C infectivity and Mipomersen inhibits hepatitis C.
World J Gastroenterol 2016 Dec;22(45):9954-9965
Esperance AK Schaefer, James Meixiong, Christina Mark, Daniel L Motola, Dahlene Fusco, Andrew Yang, Cynthia Brisac, Shadi Salloum, Wenyu Lin, Lee F Peng, Raymond T Chung, Gastrointestinal Unit, Massachusetts General Hospital, Boston, MA 02114, United States.

Hepatocyte TAZ/WWTR1 Promotes Inflammation and Fibrosis in Nonalcoholic Steatohepatitis.
Cell Metab 2016 Dec 27;24(6):848-862. Epub 2016 Oct 27.
Department of Medicine, Columbia University, New York, NY 10032, USA; Department of Pathology and Cell Biology, Columbia University, New York, NY 10032, USA; Department of Physiology and Cellular Biophysics, Columbia University, New York, NY 10032, USA. Electronic address:


IQGAP2 is a novel interferon-alpha antiviral effector gene acting non-conventionally through the NF-κB pathway.
J Hepatol 2016 Nov 9;65(5):972-979. Epub 2016 Jul 9.
Liver Center and Gastrointestinal Division, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA. Electronic address:




New perspectives for preventing hepatitis C virus liver graft infection.
Lancet Infect Dis 2016 Jun;16(6):735-745
Inserm, U1110, Institut de Recherche sur les Maladies Virales et Hépatiques, Strasbourg, France; Université de Strasbourg, Strasbourg, France; Gastrointestinal Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA; Institut Hospitalo-Universitaire, Pôle Hépato-digestif, Hôpitaux Universitaires de Strasbourg, Strasbourg, France. Electronic address:


Metformin prevents hepatocellular carcinoma development by suppressing hepatic progenitor cell activation in a rat model of cirrhosis.
Cancer 2016 Apr 23;122(8):1216-27. Epub 2016 Feb 23.
Division of Surgical Oncology, Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston, Massachusetts.

T2 relaxation time is related to liver fibrosis severity.
Quant Imaging Med Surg 2016 Apr;6(2):103-14
1 Division of Abdominal Imaging and Interventional Radiology, Department of Radiology, Massachusetts General Hospital, Boston, MA 02114, USA ; 2 Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA 02129, USA ; 3 Section for Body Imaging, Department of Radiology, Oregon Health & Sciences University, Portland, OR 97239, USA ; 4 Division of Surgical Oncology, Department of Surgery, 5 Division of Hepatology, Department of Medicine, 6 Department of Pathology, 7 Department of Biostatistics, Massachusetts General Hospital, Boston, MA 02114, USA.

HCV induces transforming growth factor β1 through activation of endoplasmic reticulum stress and the unfolded protein response.
Sci Rep 2016 Mar 1;6:22487. Epub 2016 Mar 1.
Liver Center and Gastrointestinal Division, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.





Current guidelines and prioritizing treatment of hepatitis C virus in HIV-infected patients.
Curr Opin HIV AIDS 2015 Sep;10(5):323-9
aHIV Molecular Research Group, University College Dublin, Dublin, Ireland bDivision of Gastroenterology, Massachusetts General Hospital, Boston, Massachusetts, USA cService de maladies Infectieuses et tropicales, Hôpital Bichat Claude Bernard dInserm UMR 1137, IAME eUniv Paris Diderot, Sorbonne Paris Cité, Paris, France.

EFTUD2 Is a Novel Innate Immune Regulator Restricting Hepatitis C Virus Infection through the RIG-I/MDA5 Pathway.
J Virol 2015 Jul 15;89(13):6608-18. Epub 2015 Apr 15.
Liver Center and Gastrointestinal Division, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA

Viral immunology. Comprehensive serological profiling of human populations using a synthetic human virome.
Science 2015 Jun;348(6239):aaa0698
Division of Genetics, Department of Medicine, Howard Hughes Medical Institute, Brigham and Women's Hospital, Boston, MA 02115, USA. Department of Genetics, Harvard University Medical School, Boston, MA 02115, USA. Solve ME/CFS Initiative, Los Angeles, CA 90036, USA.

Hepatic Injury in Nonalcoholic Steatohepatitis Contributes to Altered Intestinal Permeability.
Cell Mol Gastroenterol Hepatol 2015 Mar;1(2):222-232
Center for Engineering in Medicine, Department of Surgery, Massachusetts General Hospital, and the Shriners Burns Hospital, Boston, Massachusetts.


Efficacy and Safety of Direct Acting Antivirals in Kidney Transplant Recipients with Chronic Hepatitis C Virus Infection.
PLoS One 2016 14;11(7):e0158431. Epub 2016 Jul 14.
Transplantation Research Center, Renal Division, Brigham & Women's Hospital, Harvard Medical School, Boston, MA, United States of America.



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