Raymond T Chung

Raymond T Chung

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Raymond T Chung

Raymond T Chung

Publications by authors named "Raymond T Chung"

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100Publications

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The nonalcoholic fatty liver disease (NAFLD) fibrosis score, cardiovascular risk stratification and a strategy for secondary prevention with ezetimibe.

Int J Cardiol 2018 Nov 26;270:245-252. Epub 2018 May 26.

Harvard Medical School, Boston, MA, United States; TIMI Study Group, Division of Cardiovascular Medicine, Brigham and Women's Hospital, United States. Electronic address:

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November 2018

Parental non-alcoholic fatty liver disease increases risk of non-alcoholic fatty liver disease in offspring.

Liver Int 2018 Sep 4. Epub 2018 Sep 4.

Division of Gastroenterology Department of Medicine and Division of Epidemiology Department of Family and Preventive, University of California at San Diego, La Jolla, CA.

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September 2018

A novel lncRNA regulates HCV infection through IFI6.

Hepatology 2018 Sep 10. Epub 2018 Sep 10.

Liver Center and Gastrointestinal Division, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA.

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September 2018

Reply.

Hepatology 2018 Aug;68(2):793

Harvard Medical School, Boston, MA.

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August 2018

Opioid Use Disorder, Stigma, and Transplantation: A Call to Action.

Ann Intern Med 2018 Aug 10;169(3):188-189. Epub 2018 Jul 10.

Massachusetts General Hospital, Boston, Massachusetts (S.E.W., R.T.C.).

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August 2018

Heat Stroke as a Cause of Liver Failure and Evaluation of Liver Transplant.

Exp Clin Transplant 2018 Aug 17. Epub 2018 Aug 17.

Department of Surgery, Division of Organ Transplantation, UMass Memorial Medical Center, University of Massachusetts, Worcester, Massachusetts, USA.

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August 2018

Cost-effectiveness of Transplanting HCV-Infected Livers into Uninfected Recipients with Preemptive Antiviral Therapy.

Clin Gastroenterol Hepatol 2018 Aug 20. Epub 2018 Aug 20.

Massachusetts General Hospital Institute for Technology Assessment, Boston, MA; Harvard Medical School, Boston, MA; Liver Center and Gastrointestinal Division, Massachusetts General Hospital, Boston, MA. Electronic address:

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August 2018

Circulating Interleukin-6 is a biomarker for coronary atherosclerosis in nonalcoholic fatty liver disease: Results from the Multi-Ethnic Study of Atherosclerosis.

Int J Cardiol 2018 05;259:198-204

Liver Center, Gastrointestinal Division, Massachusetts General Hospital and Harvard Medical School, Boston, MA, United States. Electronic address:

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May 2018

IRGM Gene Variants Modify the Relationship Between Visceral Adipose Tissue and NAFLD in Patients With Crohn's Disease.

Inflamm Bowel Dis 2018 May 18. Epub 2018 May 18.

Division of Gastroenterology, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts.

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May 2018

Patients With Cirrhosis Require More Fecal Microbiota Capsules to Cure Refractory and Recurrent Clostridium difficile Infections.

Clin Gastroenterol Hepatol 2018 May 31. Epub 2018 May 31.

Division of Infectious Diseases, Massachusetts General Hospital, Boston, Massachusetts.

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May 2018

Reply.

Hepatology 2018 Apr 27;67(4):1641-1642. Epub 2018 Feb 27.

Massachusetts General Hospital Institute for Technology Assessment, Boston, MA.

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April 2018

Transplantation of hepatitis C virus infected kidneys into hepatitis C virus uninfected recipients.

Hemodial Int 2018 Apr;22 Suppl 1:S71-S80

Division of Nephrology, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.

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April 2018

Treatment of hepatitis C virus infection in patients with mixed cryoglobulinemic syndrome and cryoglobulinemic glomerulonephritis.

Hemodial Int 2018 Apr;22 Suppl 1:S81-S96

Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.

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April 2018

Should we treat acute hepatitis C? A decision and cost-effectiveness analysis.

Hepatology 2018 Mar 24;67(3):837-846. Epub 2018 Jan 24.

Massachusetts General Hospital Institute for Technology Assessment, Boston, MA.

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March 2018

Direct-acting antiviral therapy for hepatitis C virus infection in the kidney transplant recipient.

Kidney Int 2018 Mar 9;93(3):560-567. Epub 2018 Jan 9.

Department of Medicine, Division of Nephrology, Massachusetts General Hospital, Boston, Massachusetts, USA. Electronic address:

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March 2018

Tenofovir versus Placebo to Prevent Perinatal Transmission of Hepatitis B.

N Engl J Med 2018 Mar;378(10):911-923

From the Institut de Recherche pour le Développement Unité Mixte Internationale 174-Program for Health, Prevention, and Treatment (PHPT) (G.J., N.N.-G.-H., L.D., N.S., T.R.C.), the Faculty of Associated Medical Sciences, Chiang Mai University (G.J., N.N.-G.-H., L.D., W.K., N.S., T.R.C., W.S.), Nakornping Hospital (A.L.), Health Promotion Center Region 1 (S.S.), the Medical Department, Sanpatong Hospital (V.K.), and the Department of Internal Medicine, Faculty of Medicine, Chiang Mai University (S. Thongsawat), Chiang Mai, the Obstetrics and Gynecology Department, Chiangrai Prachanukroh Hospital (J.A.), and Mae Chan Hospital (S.B.), Chiang Rai, Prapokklao Hospital, Chantaburi (P.Y.), Banglamung Hospital (P.K.) and Chonburi Hospital (C.B., N. Chotivanich), Chonburi, Nopparat Rajathanee Hospital (O.P.N.A.), Bhumibol Adulyadej Hospital (S. Prommas), and the Faculty of Medicine, Chulalongkorn University (T.P.), Bangkok, Khon Kaen Hospital, Khon Kaen (T.S.), Samutprakarn Hospital, Samutprakarn (P. Sabsanong), Samutsakhon Hospital, Samutsakorn (S.V.), Chiang Kham Hospital (C.P.) and Phayao Hospital (P. Suriyachai), Phayao, Lampang Hospital, Lampang (P.L.), Lamphun Hospital, Lamphun (W.M.), Maharaj Nakornratchasrima Hospital, Nakornratchasrima (P.P.), and the Department of Disease Control, Ministry of Public Health, Nonthaburi (S. Thanprasertsuk) - all in Thailand; the Department of Immunology and Infectious Diseases (G.J., N.N.-G.-H., T.R.C.) and the Center for Biostatistics in AIDS Research (L.H., C.T.), Harvard T.H. Chan School of Public Health, and the Gastrointestinal Unit, Massachusetts General Hospital (R.T.C.) - both in Boston; the Department of Molecular and Clinical Pharmacology, Institute of Translational Medicine, University of Liverpool, Liverpool, United Kingdom (T.R.C.); the Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD (G.K.S., N. Chakhtoura); the Office of the Global AIDS Coordinator, Department of State, Washington, DC (D.H.W.); the Centers for Disease Control and Prevention, Atlanta (T.V.M., N.P.N.); and Université Paris Descartes, INSERM Unité 1223, Institut Pasteur, the Department of Hepato-Gastroenterology, Cochin University Hospital, Paris (S. Pol).

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March 2018

Tyrosine kinase SYK is a potential therapeutic target for liver fibrosis.

Hepatology 2018 Mar 14. Epub 2018 Mar 14.

Department of Abdominal Surgery, Integrated Hospital of Traditional Chinese Medicine, Southern Medical University, Guangzhou, China.

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March 2018

Direct-Acting Antiviral Therapy for Chronic HCV Infection Results in Liver Stiffness Regression Over 12 Months Post-treatment.

Dig Dis Sci 2018 02 8;63(2):486-492. Epub 2017 Sep 8.

Gastrointestinal Unit, Liver Center, Department of Medicine, Massachusetts General Hospital, 55 Fruit Street, Boston, MA, USA.

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February 2018

Cost Effectiveness of Pre- vs Post-Liver Transplant Hepatitis C Treatment With Direct-Acting Antivirals.

Clin Gastroenterol Hepatol 2018 Jan 17;16(1):115-122.e10. Epub 2017 Jun 17.

Institute for Technology Assessment, Massachusetts General Hospital, Boston, Massachusetts; Harvard Medical School, Boston, Massachusetts; Liver Center and Gastrointestinal Division, Massachusetts General Hospital, Boston, Massachusetts. Electronic address:

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January 2018

When and how can nephrologists treat hepatitis C virus infection in dialysis patients?

Semin Dial 2018 Jan 18;31(1):26-36. Epub 2017 Sep 18.

Division of Nephrology, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.

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January 2018

Live cell imaging of cytosolic NADH/NAD ratio in hepatocytes and liver slices.

Am J Physiol Gastrointest Liver Physiol 2018 01 12;314(1):G97-G108. Epub 2017 Oct 12.

Department of Neurobiology, Harvard Medical School , Boston, Massachusetts.

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January 2018

Reply.

Clin Gastroenterol Hepatol 2017 Dec 31;15(12):1981. Epub 2017 Aug 31.

Institute for Technology Assessment, Liver Center and Gastrointestinal Division, Massachusetts General Hospital, Boston, Massachusetts; Harvard Medical School, Boston, Massachusetts.

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December 2017

Benefits of Direct-Acting Antivirals for Hepatitis C.

Ann Intern Med 2017 Dec 17;167(11):812-813. Epub 2017 Oct 17.

From University of Michigan, Ann Arbor, Michigan; Massachusetts General Hospital, Boston, Massachusetts; Mayo Clinic, Phoenix, Arizona; Duke University School of Medicine, Durham, North Carolina; and Washington University School of Medicine, St. Louis, Missouri.

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December 2017

IDSA/AASLD Response to Cochrane Review on Direct-Acting Antivirals for Hepatitis C.

Clin Infect Dis 2017 Nov;65(11):1773-1775

Division of Gastroenterology and Hepatology, University of Michigan, Ann Arbor.

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November 2017

Comments on cochrane review on direct-acting antivirals for hepatitis C.

Hepatology 2017 10 26;66(4):1016-1019. Epub 2017 Aug 26.

Division of Infectious Diseases, Washington University School of Medicine, St. Louis, MO.

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October 2017

NAM 2017 report: A national plan to eliminate hepatitis B and C in the United States by 2030 and the AASLD's response.

Hepatology 2017 10 30;66(4):1020-1022. Epub 2017 Aug 30.

Division of Gastroenterology, University of Michigan, Ann Arbor, MI.

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October 2017

Hospital readmissions in decompensated cirrhotics: Factors pointing toward a prevention strategy.

World J Gastroenterol 2017 Oct;23(37):6868-6876

Massachusetts General Hospital, Division of Gastroenterology, Boston, MA 02114, United States.

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October 2017

Reply.

Hepatology 2017 09 1;66(3):1005-1006. Epub 2017 Aug 1.

Harvard Medical School, Boston, MA.

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September 2017

Entry Inhibitors: A Perspective for Prevention of Hepatitis C Virus Infection in Organ Transplantation.

ACS Infect Dis 2017 Sep 16;3(9):620-623. Epub 2017 Aug 16.

Inserm, U1110, Institut de Recherche sur les Maladies Virales et Hépatiques, 3 Rue Koeberlé, 67000 Strasbourg, France.

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September 2017

Development of proteinuria and focal segmental glomerulosclerosis during direct-acting antiviral therapy for hepatitis C virus infection.

Hepatology 2017 08 22;66(2):658-660. Epub 2017 Jun 22.

Division of Nephrology, Massachusetts General Hospital, Harvard Medical School, Boston, MA.

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August 2017

Nonalcoholic Steatohepatitis is Associated with Cardiac Remodeling and Dysfunction.

Obesity (Silver Spring) 2017 08;25(8):1313-1316

Liver Center, Gastrointestinal Unit, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts, USA.

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August 2017

Efficacy and Safety of Direct Acting Antivirals in Kidney Transplant Recipients with Chronic Hepatitis C Virus Infection.

PLoS One 2016 14;11(7):e0158431. Epub 2016 Jul 14.

Transplantation Research Center, Renal Division, Brigham & Women's Hospital, Harvard Medical School, Boston, MA, United States of America.

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July 2017

MELD-Na score predicts incident major cardiovascular events, in patients with nonalcoholic fatty liver disease (NAFLD).

Hepatol Commun 2017 Jul 22;1(5):429-438. Epub 2017 May 22.

Liver Center and Gastrointestinal Division, Department of Medicine, Massachusetts General Hospital.

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July 2017

Hepatitis B reactivation during or after direct acting antiviral therapy - implication for susceptible individuals.

Expert Opin Drug Saf 2017 Jun 19;16(6):651-672. Epub 2017 May 19.

a Gastrointestinal Unit , Massachusetts General Hospital , Boston , MA , USA.

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June 2017

Cost-Effectiveness of Risk Score-Stratified Hepatocellular Carcinoma Screening in Patients with Cirrhosis.

Clin Transl Gastroenterol 2017 Jun 22;8(6):e101. Epub 2017 Jun 22.

Division of Liver Diseases, Department of Medicine, Liver Cancer Program, Tisch Cancer Institute, Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, New York, USA.

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June 2017

Bariatric surgery for nonalcoholic steatohepatitis: A clinical and cost-effectiveness analysis.

Hepatology 2017 04 21;65(4):1156-1164. Epub 2017 Feb 21.

Gastrointestinal Unit, Massachusetts General Hospital, Boston, MA.

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April 2017

Most ApoL1 Is Secreted by the Liver.

J Am Soc Nephrol 2017 Apr 8;28(4):1079-1083. Epub 2016 Dec 8.

Harvard Medical School, Boston, Massachusetts.

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April 2017

Heat stroke leading to acute liver injury & failure: A case series from the Acute Liver Failure Study Group.

Liver Int 2017 04 17;37(4):509-513. Epub 2017 Feb 17.

Division of Digestive and Liver Diseases, UT Southwestern Medical Center, Dallas, TX, USA.

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April 2017

Asunaprevir Evokes Hepatocytes Innate Immunity to Restrict the Replication of Hepatitis C and Dengue Virus.

Front Microbiol 2017 20;8:668. Epub 2017 Apr 20.

Gastrointestinal Unit, Department of Medicine, Massachusetts General Hospital, Harvard UniversityBoston, MA, USA.

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April 2017

Optimal timing of hepatitis C treatment for patients on the liver transplant waiting list.

Hepatology 2017 03 6;65(3):777-788. Epub 2017 Jan 6.

Harvard Medical School, Massachusetts General Hospital, Boston, MA.

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March 2017

Perspectives on HCV: Current Therapeutic Regimens and Drug-Drug Interactions.

Clin Pharmacol Drug Dev 2017 Mar;6(2):147-163

Massachusetts General Hospital, Division of Gastroenterology, Boston, MA, USA.

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March 2017

Bi-directional analysis between fatty liver and cardiovascular disease risk factors.

J Hepatol 2017 Feb 10;66(2):390-397. Epub 2016 Oct 10.

Division of Gastroenterology, Evans Department of Medicine, Boston University School of Medicine, Boston, MA, United States. Electronic address:

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February 2017

Siglec-7 as a Novel Biomarker to Predict Mortality in Decompensated Cirrhosis and Acute Kidney Injury.

Dig Dis Sci 2016 12 21;61(12):3609-3620. Epub 2016 Sep 21.

Division of Nephrology, Department of Medicine, Massachusetts General Hospital, 55 Fruit Street, GRB 1008, Boston, MA, 02114, USA.

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December 2016

Cardiovascular Risk Reduction in Patients with Nonalcoholic Fatty Liver Disease: The Potential Role of Ezetimibe.

Dig Dis Sci 2016 12 6;61(12):3425-3435. Epub 2016 Oct 6.

Harvard Medical School, Boston, MA, USA.

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December 2016

Chronic hepatitis C infection-induced liver fibrogenesis is associated with M2 macrophage activation.

Sci Rep 2016 12 21;6:39520. Epub 2016 Dec 21.

Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.

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December 2016

Apolipoprotein B100 is required for hepatitis C infectivity and Mipomersen inhibits hepatitis C.

World J Gastroenterol 2016 Dec;22(45):9954-9965

Esperance AK Schaefer, James Meixiong, Christina Mark, Daniel L Motola, Dahlene Fusco, Andrew Yang, Cynthia Brisac, Shadi Salloum, Wenyu Lin, Lee F Peng, Raymond T Chung, Gastrointestinal Unit, Massachusetts General Hospital, Boston, MA 02114, United States.

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December 2016

Hepatocyte TAZ/WWTR1 Promotes Inflammation and Fibrosis in Nonalcoholic Steatohepatitis.

Cell Metab 2016 Dec 27;24(6):848-862. Epub 2016 Oct 27.

Department of Medicine, Columbia University, New York, NY 10032, USA; Department of Pathology and Cell Biology, Columbia University, New York, NY 10032, USA; Department of Physiology and Cellular Biophysics, Columbia University, New York, NY 10032, USA. Electronic address:

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December 2016

Anti-hepatocellular carcinoma properties of the anti-alcoholism drug disulfiram discovered to enzymatically inhibit the AMPK-related kinase SNARK in vitro.

Oncotarget 2016 Nov;7(46):74987-74999

Liver Center and Gastrointestinal Division, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.

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November 2016

IQGAP2 is a novel interferon-alpha antiviral effector gene acting non-conventionally through the NF-κB pathway.

J Hepatol 2016 Nov 9;65(5):972-979. Epub 2016 Jul 9.

Liver Center and Gastrointestinal Division, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA. Electronic address:

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November 2016

Hepatitis C Disease Burden in the United States in the era of oral direct-acting antivirals.

Hepatology 2016 11 1;64(5):1442-1450. Epub 2016 Jun 1.

Houston Veterans Affairs Health Services Research and Development Center of Excellence, Michael E. DeBakey Veterans Affairs Medical Center.

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November 2016

Treatment adherence and virological response rates in hepatitis C virus infected persons treated with sofosbuvir-based regimens: results from ERCHIVES.

Liver Int 2016 09 24;36(9):1275-83. Epub 2016 Mar 24.

University of Cincinnati College of Medicine/UC Health, Cincinnati, OH, USA.

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September 2016

Racial Disparities in Inhospital Outcomes for Hepatocellular Carcinoma in the United States.

Mayo Clin Proc 2016 Sep 3;91(9):1173-82. Epub 2016 Aug 3.

Gastroenterology Division, Massachusetts General Hospital, Boston, MA; Department of Medicine, Massachusetts General Hospital, Boston, MA; Harvard Medical School, Boston, MA.

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September 2016

Treatment of Hepatitis B: A Concise Review.

Clin Transl Gastroenterol 2016 Sep 15;7(9):e190. Epub 2016 Sep 15.

Gastroenterology Division, Massachusetts General Hospital, Boston, Massachusetts, USA.

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September 2016

Screening for Nonalcoholic Steatohepatitis in Individuals with Type 2 Diabetes: A Cost-Effectiveness Analysis.

Dig Dis Sci 2016 07 29;61(7):2108-17. Epub 2016 Jan 29.

Gastrointestinal Unit, Massachusetts General Hospital, Boston, MA, USA.

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July 2016

New perspectives for preventing hepatitis C virus liver graft infection.

Lancet Infect Dis 2016 06;16(6):735-745

Inserm, U1110, Institut de Recherche sur les Maladies Virales et Hépatiques, Strasbourg, France; Université de Strasbourg, Strasbourg, France; Gastrointestinal Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA; Institut Hospitalo-Universitaire, Pôle Hépato-digestif, Hôpitaux Universitaires de Strasbourg, Strasbourg, France. Electronic address:

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June 2016

Sofosbuvir-based regimens in clinical practice achieve SVR rates closer to clinical trials: results from ERCHIVES.

Liver Int 2016 05 25;36(5):651-8. Epub 2015 Dec 25.

University of Cincinnati College of Medicine/UC Health, Cincinnati, OH, USA.

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May 2016

Viral hepatitis: HCV compartmentalization in HCC: driver, passenger or both?

Nat Rev Gastroenterol Hepatol 2016 05 23;13(5):254-6. Epub 2016 Mar 23.

Gastroenterology Division, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, Massachusetts 02114, USA.

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May 2016

Metformin prevents hepatocellular carcinoma development by suppressing hepatic progenitor cell activation in a rat model of cirrhosis.

Cancer 2016 Apr 23;122(8):1216-27. Epub 2016 Feb 23.

Division of Surgical Oncology, Massachusetts General Hospital Cancer Center and Harvard Medical School, Boston, Massachusetts.

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April 2016

T2 relaxation time is related to liver fibrosis severity.

Quant Imaging Med Surg 2016 Apr;6(2):103-14

1 Division of Abdominal Imaging and Interventional Radiology, Department of Radiology, Massachusetts General Hospital, Boston, MA 02114, USA ; 2 Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA 02129, USA ; 3 Section for Body Imaging, Department of Radiology, Oregon Health & Sciences University, Portland, OR 97239, USA ; 4 Division of Surgical Oncology, Department of Surgery, 5 Division of Hepatology, Department of Medicine, 6 Department of Pathology, 7 Department of Biostatistics, Massachusetts General Hospital, Boston, MA 02114, USA.

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April 2016

HCV induces transforming growth factor β1 through activation of endoplasmic reticulum stress and the unfolded protein response.

Sci Rep 2016 Mar 1;6:22487. Epub 2016 Mar 1.

Liver Center and Gastrointestinal Division, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.

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March 2016

A Novel Resolvin-Based Strategy for Limiting Acetaminophen Hepatotoxicity.

Clin Transl Gastroenterol 2016 Mar 17;7:e153. Epub 2016 Mar 17.

Center for Engineering in Medicine and the Department of Surgery, Massachusetts General Hospital and the Shriners Burns Hospital, Boston, MA, USA.

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March 2016

Long noncoding RNAs expressed in human hepatic stellate cells form networks with extracellular matrix proteins.

Genome Med 2016 Mar 23;8(1):31. Epub 2016 Mar 23.

Gastrointestinal Unit, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, MA, 02114, USA.

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March 2016