Raymond R Tice

Raymond R Tice

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Raymond R Tice

Raymond R Tice

Publications by authors named "Raymond R Tice"

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Identifying Compounds with Genotoxicity Potential Using Tox21 High-Throughput Screening Assays.

Chem Res Toxicol 2019 Jul 18;32(7):1384-1401. Epub 2019 Jun 18.

Division of the National Toxicology Program , National Institute of Environmental Health Sciences , Research Triangle Park , North Carolina 27709 , United States.

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http://dx.doi.org/10.1021/acs.chemrestox.9b00053DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6740247PMC
July 2019

A high-throughput approach to identify specific neurotoxicants/ developmental toxicants in human neuronal cell function assays.

ALTEX 2018 21;35(2):235-253. Epub 2018 Jan 21.

In vitro Toxicology and Biomedicine, Dept inaugurated by the Doerenkamp-Zbinden foundation, University of Konstanz, Konstanz, Germany.

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http://dx.doi.org/10.14573/altex.1712182DOI Listing
January 2019

Real-time cell toxicity profiling of Tox21 10K compounds reveals cytotoxicity dependent toxicity pathway linkage.

PLoS One 2017 22;12(5):e0177902. Epub 2017 May 22.

Division of the National Toxicology Program, National Institute of Environmental Health Sciences, National Institutes of Health, Durham, North Carolina, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0177902PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5439695PMC
September 2017

Assessment of the DNA damaging potential of environmental chemicals using a quantitative high-throughput screening approach to measure p53 activation.

Environ Mol Mutagen 2017 08 17;58(7):494-507. Epub 2017 Jul 17.

Division of the National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina.

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http://dx.doi.org/10.1002/em.22112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5555817PMC
August 2017

Comparison of Points of Departure for Health Risk Assessment Based on High-Throughput Screening Data.

Environ Health Perspect 2017 04 6;125(4):623-633. Epub 2016 Jul 6.

Department of Risk Benefit Assessment, National Food Agency, Uppsala, Sweden.

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http://dx.doi.org/10.1289/EHP408DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5381992PMC
April 2017

Use of alternative assays to identify and prioritize organophosphorus flame retardants for potential developmental and neurotoxicity.

Neurotoxicol Teratol 2015 Nov-Dec;52(Pt B):181-93. Epub 2015 Sep 18.

Division of the National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA.

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http://dx.doi.org/10.1016/j.ntt.2015.09.003DOI Listing
October 2016

Comparative neurotoxicity screening in human iPSC-derived neural stem cells, neurons and astrocytes.

Brain Res 2016 May 5;1638(Pt A):57-73. Epub 2015 Aug 5.

XCell Science Inc., Novato, CA, USA; Buck Institute for Research on Aging, Novato, CA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.brainres.2015.07.048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5032144PMC
May 2016

Neurite outgrowth in human induced pluripotent stem cell-derived neurons as a high-throughput screen for developmental neurotoxicity or neurotoxicity.

Neurotoxicology 2016 Mar 4;53:271-281. Epub 2016 Feb 4.

Division of the National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA. Electronic address:

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http://dx.doi.org/10.1016/j.neuro.2016.02.003DOI Listing
March 2016

Identification of genotoxic compounds using isogenic DNA repair deficient DT40 cell lines on a quantitative high throughput screening platform.

Mutagenesis 2016 Jan 4;31(1):69-81. Epub 2015 Aug 4.

National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, MSC: 3375 Bethesda, MD 20892, USA and

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http://dx.doi.org/10.1093/mutage/gev055DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4723671PMC
January 2016

A Data Analysis Pipeline Accounting for Artifacts in Tox21 Quantitative High-Throughput Screening Assays.

J Biomol Screen 2015 Aug 22;20(7):887-97. Epub 2015 Apr 22.

Division of the National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA.

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http://dx.doi.org/10.1177/1087057115581317DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4568956PMC
August 2015

RNA-Seq-based toxicogenomic assessment of fresh frozen and formalin-fixed tissues yields similar mechanistic insights.

J Appl Toxicol 2015 Jul 6;35(7):766-80. Epub 2014 Nov 6.

Biomolecular Screening Branch, Division of the National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, NC, 27709, USA.

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http://dx.doi.org/10.1002/jat.3068DOI Listing
July 2015

The JaCVAM international validation study on the in vivo comet assay: Selection of test chemicals.

Mutat Res Genet Toxicol Environ Mutagen 2015 Jul 7;786-788:14-44. Epub 2015 Mar 7.

Innovative Toxicology Consulting, LLC, Lake Worth, FL 33467, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S13835718150004
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http://dx.doi.org/10.1016/j.mrgentox.2015.03.004DOI Listing
July 2015

Estrogenic and anti-estrogenic activity of off-the-shelf hair and skin care products.

J Expo Sci Environ Epidemiol 2015 May 21;25(3):271-7. Epub 2014 May 21.

Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA.

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http://dx.doi.org/10.1038/jes.2014.32DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4318791PMC
May 2015

FutureTox II: in vitro data and in silico models for predictive toxicology.

Toxicol Sci 2015 Feb;143(2):256-67

United States Environmental Protection Agency, Research Triangle Park, North Carolina 27711, Sanofi, Bridgewater, New Jersey 08807, Page One Editorial Services, Boulder, Colorado 80304, Dow Chemical Company, Midland, Michigan 48674, Health and Environmental Sciences Institute, Washington, District of Columbia 20005, University of Washington, Seattle, Washington 98105, United States Food and Drug Administration, Silver Spring, Maryland 20993, Sanofi, Bethesda, Maryland 20814, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, University of North Carolina, Chapel Hill, North Carolina 27599, The Hamner Institutes, Research Triangle Park, North Carolina 27709, and European Commission Joint Research Centre, I-21027 Ispra, Italy.

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https://academic.oup.com/toxsci/article-lookup/doi/10.1093/t
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http://dx.doi.org/10.1093/toxsci/kfu234DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4318934PMC
February 2015

Intersection of toxicogenomics and high throughput screening in the Tox21 program: an NIEHS perspective.

Int J Biotechnol 2015;14(1):7-27

Biomolecular Screening Branch, Division of the National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, USA.

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http://dx.doi.org/10.1504/IJBT.2015.074797DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4844067PMC
January 2015

Mitochondria, energetics, epigenetics, and cellular responses to stress.

Environ Health Perspect 2014 Dec 15;122(12):1271-8. Epub 2014 Aug 15.

Division of Extramural Research and Training, National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health (NIH), Department of Health and Human Services (DHHS), Research Triangle Park, North Carolina, USA.

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http://dx.doi.org/10.1289/ehp.1408418DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4256704PMC
December 2014

RNA-Seq profiling reveals novel hepatic gene expression pattern in aflatoxin B1 treated rats.

PLoS One 2013 22;8(4):e61768. Epub 2013 Apr 22.

Division of the National Toxicology Program, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0061768PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3632591PMC
November 2013

Systematic study of mitochondrial toxicity of environmental chemicals using quantitative high throughput screening.

Chem Res Toxicol 2013 Sep 15;26(9):1323-32. Epub 2013 Aug 15.

National Center for Advancing Translational Sciences, National Institutes of Health , Bethesda, Maryland 20892, United States.

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http://dx.doi.org/10.1021/tx4001754DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4154066PMC
September 2013

The Tox21 robotic platform for the assessment of environmental chemicals--from vision to reality.

Drug Discov Today 2013 Aug 31;18(15-16):716-23. Epub 2013 May 31.

NIH Chemical Genomics Center, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, MD 20850, USA.

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http://dx.doi.org/10.1016/j.drudis.2013.05.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3771082PMC
August 2013

Improving the human hazard characterization of chemicals: a Tox21 update.

Environ Health Perspect 2013 Jul 19;121(7):756-65. Epub 2013 Apr 19.

Division of the National Toxicology Program, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina, USA.

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http://dx.doi.org/10.1289/ehp.1205784DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3701992PMC
July 2013

Bisphenol A affects androgen receptor function via multiple mechanisms.

Chem Biol Interact 2013 May 4;203(3):556-64. Epub 2013 Apr 4.

DNTP Biomolecular Screening Branch, National Institute of Environmental Health Sciences, National Institutes of Health (NIH), Research Triangle Park, NC, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S00092797130007
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http://dx.doi.org/10.1016/j.cbi.2013.03.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3722857PMC
May 2013

Endocrine-Disrupting Chemicals (EDCs): In Vitro Mechanism of Estrogenic Activation and Differential Effects on ER Target Genes.

Environ Health Perspect 2013 Apr 5;121(4):459-66. Epub 2013 Feb 5.

Receptor Biology Section, Laboratory of Reproductive and Developmental Toxicology, Division of Intramural Research, National Institute of Environmental Health Sciences (NIEHS), National Institutes of Health (NIH), Department of Health and Human Services (DHHS), Research Triangle Park, North Carolina 27709, USA.

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https://ehp.niehs.nih.gov/doi/10.1289/ehp.1205951
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http://dx.doi.org/10.1289/ehp.1205951DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3620735PMC
April 2013

Prediction of Cytochrome P450 Profiles of Environmental Chemicals with QSAR Models Built from Drug-like Molecules.

Mol Inform 2012 Nov 11;31(11-12):783-792. Epub 2012 Oct 11.

National Center for Advancing Translational Sciences, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, USA.

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http://dx.doi.org/10.1002/minf.201200065DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3583379PMC
November 2012

Profiling environmental chemicals for activity in the antioxidant response element signaling pathway using a high throughput screening approach.

Environ Health Perspect 2012 Aug 2;120(8):1150-6. Epub 2012 May 2.

NIH Chemical Genomics Center, National Institutes of Health, Department of Health and Human Services, Rockville, Maryland, USA.

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http://dx.doi.org/10.1289/ehp.1104709DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3440086PMC
August 2012

Application of a homogenous membrane potential assay to assess mitochondrial function.

Physiol Genomics 2012 May 20;44(9):495-503. Epub 2012 Mar 20.

NIH Chemical Genomics Center, National Institutes of Health, Bethesda, Maryland 20892-3370, USA.

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http://dx.doi.org/10.1152/physiolgenomics.00161.2011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3426425PMC
May 2012

Testing an aflatoxin B1 gene signature in rat archival tissues.

Chem Res Toxicol 2012 May 4;25(5):1132-44. Epub 2012 May 4.

Biomolecular Screening Branch, Division of the National Toxicology Program, National Institute of Environmental Health Sciences , Research Triangle Park, NC 27709, United States.

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http://dx.doi.org/10.1021/tx3000945DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3358548PMC
May 2012

High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.

Proc Natl Acad Sci U S A 2012 Apr 19;109(14):5423-8. Epub 2012 Mar 19.

Genome Instability Section, Genetics and Molecular Biology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1073/pnas.1114278109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3325711PMC
April 2012

Chemical genomics profiling of environmental chemical modulation of human nuclear receptors.

Environ Health Perspect 2011 Aug 4;119(8):1142-8. Epub 2011 May 4.

National Institutes of Health Chemical Genomics Center, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892-3370, USA.

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https://ehp.niehs.nih.gov/doi/10.1289/ehp.1002952
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http://dx.doi.org/10.1289/ehp.1002952DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3237348PMC
August 2011

Genetic toxicology in the 21st century: reflections and future directions.

Environ Mol Mutagen 2011 Jun 28;52(5):339-54. Epub 2011 Apr 28.

Merck Research Laboratories, Genetic Toxicology, Mechanistic and Predictive Toxicology, Summit, New Jersey, USA.

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http://dx.doi.org/10.1002/em.20653DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3160238PMC
June 2011

Identification of quaternary ammonium compounds as potent inhibitors of hERG potassium channels.

Toxicol Appl Pharmacol 2011 May 26;252(3):250-8. Epub 2011 Feb 26.

NIH Chemical Genomics Center, National Institutes of Health, Bethesda, MD 20892-3370, USA.

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http://dx.doi.org/10.1016/j.taap.2011.02.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3079779PMC
May 2011

Identification of chemical compounds that induce HIF-1alpha activity.

Toxicol Sci 2009 Nov 5;112(1):153-63. Epub 2009 Jun 5.

NIH Chemical Genomics Center, National Institutes of Health, Bethesda, Maryland 20892, USA.

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https://academic.oup.com/toxsci/article-lookup/doi/10.1093/t
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http://dx.doi.org/10.1093/toxsci/kfp123DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2910898PMC
November 2009

Toxicity testing in the 21st century: implications for human health risk assessment.

Risk Anal 2009 Apr 9;29(4):485-7; discussion 492-7. Epub 2008 Dec 9.

National Center for Computational Toxicology, Office of Research and Development, U.S. Environmental Protection Agency, Research Triangle Park, NC 27711, USA.

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http://doi.wiley.com/10.1111/j.1539-6924.2008.01168.x
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http://dx.doi.org/10.1111/j.1539-6924.2008.01168.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3202604PMC
April 2009

Compound cytotoxicity profiling using quantitative high-throughput screening.

Environ Health Perspect 2008 Mar;116(3):284-91

NIH Chemical Genomics Center, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892-3370, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/2265061/
Publisher Site
http://dx.doi.org/10.1289/ehp.10727DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2265061PMC
March 2008

Comparison of flow cytometry- and microscopy-based methods for measuring micronucleated reticulocyte frequencies in rodents treated with nongenotoxic and genotoxic chemicals.

Mutat Res 2008 Jan 11;649(1-2):101-13. Epub 2007 Aug 11.

Environmental Toxicology Program, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA.

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http://dx.doi.org/10.1016/j.mrgentox.2007.08.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2234598PMC
January 2008

Genetic damage detected in CD-1 mouse pups exposed perinatally to 3'-azido-3'-deoxythymidine or dideoxyinosine via maternal dosing, nursing, and direct gavage: II. Effects of the individual agents compared to combination treatment.

Environ Mol Mutagen 2004 ;44(4):321-8

National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA.

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http://dx.doi.org/10.1002/em.20048DOI Listing
December 2004

Genetic damage detected in CD-1 mouse pups exposed perinatally to 3'-azido-3'-deoxythymidine and dideoxyinosine via maternal dosing, nursing, and direct gavage.

Environ Mol Mutagen 2004 ;43(1):3-9

National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA.

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http://dx.doi.org/10.1002/em.10210DOI Listing
March 2004

Genotoxicity of radiofrequency signals. I. Investigation of DNA damage and micronuclei induction in cultured human blood cells.

Bioelectromagnetics 2002 Feb;23(2):113-26

ILS, Inc., Research Triangle Park, North Carolina 27709, USA.

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February 2002