Raymond J Monnat

Raymond J Monnat

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Raymond J Monnat

Raymond J Monnat

Publications by authors named "Raymond J Monnat"

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New Human Chromosomal Sites with "Safe Harbor" Potential for Targeted Transgene Insertion.

Hum Gene Ther 2019 Jul 28;30(7):814-828. Epub 2019 Mar 28.

1Department of Pathology, University of Washington, Seattle, Washington.

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http://dx.doi.org/10.1089/hum.2018.169DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6648220PMC
July 2019

An RNAi screen in human cell lines reveals conserved DNA damage repair pathways that mitigate formaldehyde sensitivity.

DNA Repair (Amst) 2018 12 9;72:1-9. Epub 2018 Oct 9.

Department of Molecular and Medical Genetics, Oregon Health & Science University, Portland, OR, 97239, United States; Oregon Institute of Occupational Health Sciences, Oregon Health & Science University, Portland, OR, 97239, United States. Electronic address:

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http://dx.doi.org/10.1016/j.dnarep.2018.10.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6652219PMC
December 2018

Werner syndrome (WRN) gene variants and their association with altered function and age-associated diseases.

Ageing Res Rev 2018 Jan 14;41:82-97. Epub 2017 Nov 14.

Departments of Pathology and Genome Sciences, University of Washington, Seattle, WA 98195, USA.

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http://dx.doi.org/10.1016/j.arr.2017.11.003DOI Listing
January 2018

Human RECQ Helicase Pathogenic Variants, Population Variation and "Missing" Diseases.

Hum Mutat 2017 02 9;38(2):193-203. Epub 2016 Dec 9.

Department of Genome Sciences, University of Washington, Seattle, Washington.

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http://dx.doi.org/10.1002/humu.23148DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5518694PMC
February 2017

Werner syndrome: Clinical features, pathogenesis and potential therapeutic interventions.

Ageing Res Rev 2017 Jan 15;33:105-114. Epub 2016 Mar 15.

Department of Pathology, University of Washington, Seattle, WA 98195, USA; Department of Genome Sciences, University of Washington, Seattle, WA 98195, USA.

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http://dx.doi.org/10.1016/j.arr.2016.03.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5025328PMC
January 2017

Metformin improves defective hematopoiesis and delays tumor formation in Fanconi anemia mice.

Blood 2016 12 18;128(24):2774-2784. Epub 2016 Oct 18.

Oregon Stem Cell Center, Department of Pediatrics, Oregon Health & Science University, Portland, OR.

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http://dx.doi.org/10.1182/blood-2015-11-683490DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5159699PMC
December 2016

The Werner syndrome RECQ helicase targets G4 DNA in human cells to modulate transcription.

Hum Mol Genet 2016 05 16;25(10):2060-2069. Epub 2016 Mar 16.

Department of Pathology, Department of Genome Sciences, University of Washington, Seattle, WA, USA,

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http://dx.doi.org/10.1093/hmg/ddw079DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5062591PMC
May 2016

Development of a Whole Blood Paper-Based Device for Phenylalanine Detection in the Context of PKU Therapy Monitoring.

Micromachines (Basel) 2016 Feb 15;7(2). Epub 2016 Feb 15.

School of Chemical, Biological, and Environmental Engineering, Oregon State University, Corvallis, OR 97331, USA.

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http://dx.doi.org/10.3390/mi7020028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6190008PMC
February 2016

Microwell arrays reveal cellular heterogeneity during the clonal expansion of transformed human cells.

Technology (Singap World Sci) 2015 Dec;3(4):163-171

Departments of Bioengineering, University of Washington, Seattle, WA 98195, USA.

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http://dx.doi.org/10.1142/S2339547815200046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4854201PMC
December 2015

MRE11-deficiency associated with improved long-term disease free survival and overall survival in a subset of stage III colon cancer patients in randomized CALGB 89803 trial.

PLoS One 2014 13;9(10):e108483. Epub 2014 Oct 13.

Department of Immunology, University of Washington, Seattle, Washington, United States of America; Molecular and Cellular Biology Graduate Program, University of Washington, Seattle, Washington, United States of America; Department of Pathology, University of Washington Medical School, Seattle, Washington, United States of America; Department of Biochemistry, University of Washington, Seattle, Washington, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0108483PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4195600PMC
June 2015

"...Rewritten in the skin": clues to skin biology and aging from inherited disease.

Authors:
Raymond J Monnat

J Invest Dermatol 2015 Jun 26;135(6):1484-1490. Epub 2015 Mar 26.

Department of Pathology and Genome Sciences, University of Washington, Seattle, Washington, USA. Electronic address:

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http://dx.doi.org/10.1038/jid.2015.88DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4526269PMC
June 2015

Global and disease-associated genetic variation in the human Fanconi anemia gene family.

Hum Mol Genet 2014 Dec 7;23(25):6815-25. Epub 2014 Aug 7.

Department of Genome Sciences and Department of Pathology, University of Washington, Seattle, WA 98195, USA

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http://dx.doi.org/10.1093/hmg/ddu400DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4245043PMC
December 2014

Parallel microfluidic chemosensitivity testing on individual slice cultures.

Lab Chip 2014 Dec 2;14(23):4540-51. Epub 2014 Oct 2.

Department of Bioengineering, University of Washington, Seattle, WA, USA.

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http://dx.doi.org/10.1039/c4lc00642aDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4217250PMC
December 2014

Quantifying the information content of homing endonuclease target sites by single base pair profiling.

Methods Mol Biol 2014 ;1123:135-49

Departments of Biochemistry and Pathology, University of Washington, Seattle, WA, USA.

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http://dx.doi.org/10.1007/978-1-62703-968-0_11DOI Listing
October 2014

Homing endonuclease target site specificity defined by sequential enrichment and next-generation sequencing of highly complex target site libraries.

Methods Mol Biol 2014 ;1123:151-63

Department of Pathology, University of Washington, Seattle, WA, USA.

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http://dx.doi.org/10.1007/978-1-62703-968-0_12DOI Listing
October 2014

Identification and analysis of genomic homing endonuclease target sites.

Methods Mol Biol 2014 ;1123:245-64

Department of Pathology, University of Washington, Seattle, WA, USA.

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http://dx.doi.org/10.1007/978-1-62703-968-0_16DOI Listing
October 2014

Diabetes mellitus and cancer in Werner syndrome.

Acta Diabetol 2014 Feb 6;51(1):159-61. Epub 2013 Feb 6.

Department of Epidemiology, University of Washington, Seattle, WA, 98195-7705, USA.

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http://depts.washington.edu/monnatws/pdf/2014_Lauper.pdf
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http://link.springer.com/10.1007/s00592-013-0456-z
Publisher Site
http://dx.doi.org/10.1007/s00592-013-0456-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3669637PMC
February 2014

Altered RECQ Helicase Expression in Sporadic Primary Colorectal Cancers.

Transl Oncol 2013 Aug 1;6(4):458-69. Epub 2013 Aug 1.

Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA ; Department of Surgery, University of Washington Medical School, Seattle, WA ; Department of Surgery, University of Nebraska Medical School, Omaha, NE.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3730021PMC
http://dx.doi.org/10.1593/tlo.13238DOI Listing
August 2013

PARP-mediated repair, homologous recombination, and back-up non-homologous end joining-like repair of single-strand nicks.

DNA Repair (Amst) 2013 Jul 16;12(7):529-34. Epub 2013 May 16.

Division of Basic Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave. N., Seattle, WA 98109, USA.

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http://dx.doi.org/10.1016/j.dnarep.2013.04.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3683368PMC
July 2013

Rapid assessment of RNAi-mediated protein depletion by selected reaction monitoring mass spectrometry.

J Proteome Res 2013 Jul 10;12(7):3246-54. Epub 2013 Jun 10.

Departments of Genome Sciences and Pathology, University of Washington, Seattle, Washington 98195, USA.

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http://dx.doi.org/10.1021/pr400067kDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3767422PMC
July 2013

Essential role for Cdk2 inhibitory phosphorylation during replication stress revealed by a human Cdk2 knockin mutation.

Proc Natl Acad Sci U S A 2013 May 13;110(22):8954-9. Epub 2013 May 13.

Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.

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http://dx.doi.org/10.1073/pnas.1302927110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3670391PMC
May 2013

Comprehensive homing endonuclease target site specificity profiling reveals evolutionary constraints and enables genome engineering applications.

Nucleic Acids Res 2012 Mar 25;40(6):2587-98. Epub 2011 Nov 25.

Department of Pathology, University of Washington, Box 357705, Seattle, WA 98195, USA.

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http://dx.doi.org/10.1093/nar/gkr1072DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3315327PMC
March 2012

Comprehensive computational design of mCreI homing endonuclease cleavage specificity for genome engineering.

Nucleic Acids Res 2011 May 1;39(10):4330-9. Epub 2011 Feb 1.

Department of Biochemistry, Howard Hughes Medical InstituteUniversity of Washington, Box 357705, Seattle, WA 98195, USA.

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http://dx.doi.org/10.1093/nar/gkr022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3105429PMC
May 2011

Human RECQ helicases: roles in DNA metabolism, mutagenesis and cancer biology.

Authors:
Raymond J Monnat

Semin Cancer Biol 2010 Oct 8;20(5):329-39. Epub 2010 Oct 8.

Department of Pathology, University of Washington, Seattle, WA 98195-7705, USA.

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http://dx.doi.org/10.1016/j.semcancer.2010.10.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3040982PMC
October 2010

The human WRN and BLM RecQ helicases differentially regulate cell proliferation and survival after chemotherapeutic DNA damage.

Cancer Res 2010 Aug 27;70(16):6548-55. Epub 2010 Jul 27.

Department of Pathology, University of Washington, Seattle, Washington 98195-7705, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-10-0475DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2941797PMC
August 2010

Human RECQ1 and RECQ4 helicases play distinct roles in DNA replication initiation.

Mol Cell Biol 2010 Mar 11;30(6):1382-96. Epub 2010 Jan 11.

International Centre for Genetic Engineering and Biotechnology, Padriciano 99, 34149 Trieste, Italy.

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http://dx.doi.org/10.1128/MCB.01290-09DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2832491PMC
March 2010

Microfluidic-assisted analysis of replicating DNA molecules.

Nat Protoc 2009 14;4(6):849-61. Epub 2009 May 14.

Department of Pathology, University of Washington, Seattle, Washington, USA.

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http://dx.doi.org/10.1038/nprot.2009.54DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2762429PMC
September 2009

Human DNA polymerase eta is required for common fragile site stability during unperturbed DNA replication.

Mol Cell Biol 2009 Jun 20;29(12):3344-54. Epub 2009 Apr 20.

CNRS, IPBS (Institute of Pharmacology and Structural Biology), 205 Route de Narbonne, F-31077 Toulouse, France.

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http://dx.doi.org/10.1128/MCB.00115-09DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2698728PMC
June 2009

Generation of single-chain LAGLIDADG homing endonucleases from native homodimeric precursor proteins.

Nucleic Acids Res 2009 Apr 19;37(5):1650-62. Epub 2009 Jan 19.

Department of Pathology, University of Washington, Box 357705, Seattle, WA 98195, USA.

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https://academic.oup.com/nar/article-lookup/doi/10.1093/nar/
Publisher Site
http://dx.doi.org/10.1093/nar/gkp004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2655683PMC
April 2009

Generation of a nicking enzyme that stimulates site-specific gene conversion from the I-AniI LAGLIDADG homing endonuclease.

Proc Natl Acad Sci U S A 2009 Mar 10;106(13):5099-104. Epub 2009 Mar 10.

Division of Basic Sciences, Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue, North Seattle, WA 98109, USA.

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http://dx.doi.org/10.1073/pnas.0810588106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2664052PMC
March 2009

Assessment of protein dynamics and DNA repair following generation of DNA double-strand breaks at defined genomic sites.

Nat Protoc 2008 ;3(5):915-22

Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel.

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http://dx.doi.org/10.1038/nprot.2008.54DOI Listing
August 2008

DNA polymerases and human disease.

Nat Rev Genet 2008 Aug;9(8):594-604

Department of Pathology University of Washington, K-072 HSB, BOX 357705, Seattle, Washington 98195-7705, USA.

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http://dx.doi.org/10.1038/nrg2345DOI Listing
August 2008

The RecQ helicase WRN is required for normal replication fork progression after DNA damage or replication fork arrest.

Cell Cycle 2008 Mar 4;7(6):796-807. Epub 2008 Jan 4.

Department of Pathology, University of Washington, Seattle, Washington 98195-7705, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4362724PMC
http://dx.doi.org/10.4161/cc.7.6.5566DOI Listing
March 2008

Altered target site specificity variants of the I-PpoI His-Cys box homing endonuclease.

Nucleic Acids Res 2007 24;35(17):5839-50. Epub 2007 Aug 24.

Department of Genome Sciences, University of Washington, Seattle, WA, USA.

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http://dx.doi.org/10.1093/nar/gkm624DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2034468PMC
November 2007

From broken to old: DNA damage, IGF1 endocrine suppression and aging.

Authors:
Raymond J Monnat

DNA Repair (Amst) 2007 Sep 3;6(9):1386-90. Epub 2007 May 3.

Department of Pathology, University of Washington, Box 357705 Seattle, WA 98195-7705, United States.

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http://dx.doi.org/10.1016/j.dnarep.2007.03.018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2704237PMC
September 2007

Roles of ATM and NBS1 in chromatin structure modulation and DNA double-strand break repair.

Nat Cell Biol 2007 Jun 7;9(6):683-90. Epub 2007 May 7.

Department of Oncology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.

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http://dx.doi.org/10.1038/ncb1599DOI Listing
June 2007

Werner and Hutchinson-Gilford progeria syndromes: mechanistic basis of human progeroid diseases.

Nat Rev Mol Cell Biol 2007 May;8(5):394-404

Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.

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http://www.nature.com/articles/nrm2161
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http://dx.doi.org/10.1038/nrm2161DOI Listing
May 2007

Functional role of the Werner syndrome RecQ helicase in human fibroblasts.

Aging Cell 2007 Feb;6(1):53-61

Department of Pathology, University of Washington, Seattle, WA 98195-7705, USA.

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http://dx.doi.org/10.1111/j.1474-9726.2006.00260.xDOI Listing
February 2007

Computational redesign of endonuclease DNA binding and cleavage specificity.

Nature 2006 Jun;441(7093):656-9

Howard Hughes Medical Institute and Department of Biochemistry, University of Washington, Seattle, Washington 98195, USA.

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http://dx.doi.org/10.1038/nature04818DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2999987PMC
June 2006

Metal-dependent DNA cleavage mechanism of the I-CreI LAGLIDADG homing endonuclease.

Biochemistry 2004 Nov;43(44):14015-26

Graduate Program in Molecular and Cellular Biology, University of Washington and Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North A3-025, Seattle, Washington 98109, USA.

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https://pubs.acs.org/doi/10.1021/bi048970c
Publisher Site
http://dx.doi.org/10.1021/bi048970cDOI Listing
November 2004

The Werner syndrome protein has separable recombination and survival functions.

DNA Repair (Amst) 2004 May;3(5):475-82

Department of Pathology, University of Washington, Box 357705, Seattle, WA 98195-7705, USA.

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http://dx.doi.org/10.1016/j.dnarep.2004.01.002DOI Listing
May 2004

Werner syndrome protein--unwinding function to explain disease.

Sci Aging Knowledge Environ 2004 Mar 31;2004(13):re3. Epub 2004 Mar 31.

Department of Pathology, University of Washington, Seattle, WA 98195, USA.

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http://dx.doi.org/10.1126/sageke.2004.13.re3DOI Listing
March 2004

Flexible DNA target site recognition by divergent homing endonuclease isoschizomers I-CreI and I-MsoI.

J Mol Biol 2003 May;329(2):253-69

Division of Basic Sciences, Graduate Program in Molecular and Cellular Biology, University of Washington and the Fred Hutchinson Cancer Research Center, Seattle 98109, USA.

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http://dx.doi.org/10.1016/s0022-2836(03)00447-9DOI Listing
May 2003

Homologous recombination resolution defect in werner syndrome.

Mol Cell Biol 2002 Oct;22(20):6971-8

Departments of Pathology. Biostatistics. Genome Sciences, University of Washington, Seattle, Washington 98195-7705, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC139822PMC
http://dx.doi.org/10.1128/mcb.22.20.6971-6978.2002DOI Listing
October 2002

Design, activity, and structure of a highly specific artificial endonuclease.

Mol Cell 2002 Oct;10(4):895-905

Fred Hutchinson Cancer Research Center and Graduate Program in Molecular and Cell Biology, University of Washington, 1100 Fairview Avenue N. A3-023, Seattle, WA 98109, USA.

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http://dx.doi.org/10.1016/s1097-2765(02)00690-1DOI Listing
October 2002

The unexpected landscape of in vivo somatic mutation in a human epithelial cell lineage.

Proc Natl Acad Sci U S A 2002 Feb 29;99(3):1437-42. Epub 2002 Jan 29.

Department of Pathology, University of Washington, Box 357705, Seattle, WA 98195-7705, USA.

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http://dx.doi.org/10.1073/pnas.032655699DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC122209PMC
February 2002