Ray Truant

Ray Truant

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Ray Truant

Ray Truant

Publications by authors named "Ray Truant"

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High-mobility group box 1 links sensing of reactive oxygen species by huntingtin to its nuclear entry.

J Biol Chem 2019 02 11;294(6):1915-1923. Epub 2018 Dec 11.

From the Department of Biochemistry and Biomedical Research, McMaster University, Hamilton, Ontario L8S 4L8, Canada

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http://dx.doi.org/10.1074/jbc.RA117.001440DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6369305PMC
February 2019

DNA Repair Signaling of Huntingtin: The Next Link Between Late-Onset Neurodegenerative Disease and Oxidative DNA Damage.

DNA Cell Biol 2019 Jan 27;38(1):1-6. Epub 2018 Nov 27.

Department of Biochemistry and Biomedical Sciences, McMaster University , Hamilton, Canada .

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http://dx.doi.org/10.1089/dna.2018.4476DOI Listing
January 2019

Bacteria Getting into Shape: Genetic Determinants of Morphology.

MBio 2017 03 7;8(2). Epub 2017 Mar 7.

Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada

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http://dx.doi.org/10.1128/mBio.01977-16DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5340871PMC
March 2017

DNA repair: A unifying mechanism in neurodegeneration.

Nature 2017 01 21;541(7635):34-35. Epub 2016 Dec 21.

Departments of Psychiatry, Neurology, Neuroscience and Pharmacology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA.

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http://www.nature.com/articles/nature21107
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http://dx.doi.org/10.1038/nature21107DOI Listing
January 2017

Huntingtin is a scaffolding protein in the ATM oxidative DNA damage response complex.

Hum Mol Genet 2017 01;26(2):395-406

Department of Biochemistry and Biomedical Research, McMaster University, HSC 4N54, 1200 Main Street West, Hamilton, Canada L8N3Z5.

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http://dx.doi.org/10.1093/hmg/ddw395DOI Listing
January 2017

DIXDC1 Phosphorylation and Control of Dendritic Morphology Are Impaired by Rare Genetic Variants.

Cell Rep 2016 11;17(7):1892-1904

Stem Cell and Cancer Research Institute, Faculty of Health Sciences, McMaster University, Hamilton, ON L8N 3Z5, Canada; Department of Biochemistry and Biomedical Sciences, Michael G. DeGroote School of Medicine, Faculty of Health Sciences, McMaster University, Hamilton, ON L8N 3Z5, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.10.047DOI Listing
November 2016

Huntingtin N17 domain is a reactive oxygen species sensor regulating huntingtin phosphorylation and localization.

Hum Mol Genet 2016 09 27;25(18):3937-3945. Epub 2016 Jul 27.

Department of Biochemistry and Biomedical Research, McMaster University, Hamilton, ON L8N3Z5, Canada

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http://dx.doi.org/10.1093/hmg/ddw234DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5291230PMC
September 2016

A huntingtin-mediated fast stress response halting endosomal trafficking is defective in Huntington's disease.

Hum Mol Genet 2015 Jan 8;24(2):450-62. Epub 2014 Sep 8.

Department of Biochemistry and Biomedical Sciences, Michael G. DeGroote School of Medicine, Faculty of Health Sciences, McMaster University, Hamilton, ON, Canada L8N 3Z5 and

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http://hmg.oxfordjournals.org/content/24/2/450.full.pdf
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http://www.hmg.oxfordjournals.org/cgi/doi/10.1093/hmg/ddu460
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http://dx.doi.org/10.1093/hmg/ddu460DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4275073PMC
January 2015

Live cell imaging and biophotonic methods reveal two types of mutant huntingtin inclusions.

Hum Mol Genet 2014 May 11;23(9):2324-38. Epub 2013 Dec 11.

Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON, Canada L8N 3Z5.

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http://dx.doi.org/10.1093/hmg/ddt625DOI Listing
May 2014

The role of the cofilin-actin rod stress response in neurodegenerative diseases uncovers potential new drug targets.

Bioarchitecture 2012 Nov-Dec;2(6):204-8

McMaster University, Department of Biochemistry and Biomedical Sciences, Hamilton, Canada.

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http://dx.doi.org/10.4161/bioa.22549DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3527314PMC
January 2014

Polyglutamine domain flexibility mediates the proximity between flanking sequences in huntingtin.

Proc Natl Acad Sci U S A 2013 Sep 29;110(36):14610-5. Epub 2013 Jul 29.

Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON, Canada L8N 3Z5.

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http://dx.doi.org/10.1073/pnas.1301342110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3767516PMC
September 2013

A multifunctional, multi-pathway intracellular localization signal in Huntingtin.

Commun Integr Biol 2013 Mar;6(2):e23318

Department of Biochemistry and Biomedical Sciences; McMaster University; Hamilton, ON Canada.

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http://dx.doi.org/10.4161/cib.23318DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3609847PMC
March 2013

Using FLIM-FRET to measure conformational changes of transglutaminase type 2 in live cells.

PLoS One 2012 31;7(8):e44159. Epub 2012 Aug 31.

Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0044159PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3432096PMC
February 2013

Identification of a karyopherin β1/β2 proline-tyrosine nuclear localization signal in huntingtin protein.

J Biol Chem 2012 Nov 25;287(47):39626-33. Epub 2012 Sep 25.

Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada L8N3Z5.

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http://dx.doi.org/10.1074/jbc.M112.412379DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3501053PMC
November 2012

Cofilin nuclear-cytoplasmic shuttling affects cofilin-actin rod formation during stress.

J Cell Sci 2012 Sep 23;125(Pt 17):3977-88. Epub 2012 May 23.

Department of Biochemistry and Biomedical Sciences, McMaster University, 1200 Main Street West, Hamilton, Ontario, Canada, L8N 3Z5.

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http://jcs.biologists.org/lookup/doi/10.1242/jcs.097667
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http://dx.doi.org/10.1242/jcs.097667DOI Listing
September 2012

Mutant huntingtin causes defective actin remodeling during stress: defining a new role for transglutaminase 2 in neurodegenerative disease.

Hum Mol Genet 2011 May 25;20(10):1937-51. Epub 2011 Feb 25.

Department of Biochemistry and Biomedical Sciences, McMaster University, 1200 Main Street West, Hamilton, Ontario, Canada L8N3Z5.

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http://dx.doi.org/10.1093/hmg/ddr075DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3080606PMC
May 2011

Kinase inhibitors modulate huntingtin cell localization and toxicity.

Nat Chem Biol 2011 May 29;7(7):453-60. Epub 2011 May 29.

Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada.

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http://dx.doi.org/10.1038/nchembio.582DOI Listing
May 2011

In vivo formation of protein based aqueous microcompartments.

J Am Chem Soc 2009 Jul;131(25):9094-9

Department of Chemical Engineering, McMaster University, Hamilton, ON L8S 4L7 Canada.

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http://dx.doi.org/10.1021/ja902890rDOI Listing
July 2009

Determination of the topology of the hydrophobic segment of mammalian diacylglycerol kinase epsilon in a cell membrane and its relationship to predictions from modeling.

J Mol Biol 2008 Nov 6;383(4):797-809. Epub 2008 Sep 6.

Faculté Universitaire des Sciences Agronomiques de Gembloux, Centre de Biophysique Moléculaire Numérique, Passage des Déportés, 2, 5030 Gembloux, Belgium.

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http://dx.doi.org/10.1016/j.jmb.2008.08.076DOI Listing
November 2008

Huntington's disease: revisiting the aggregation hypothesis in polyglutamine neurodegenerative diseases.

FEBS J 2008 Sep 15;275(17):4252-62. Epub 2008 Jul 15.

Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Canada.

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http://dx.doi.org/10.1111/j.1742-4658.2008.06561.xDOI Listing
September 2008

Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes.

Authors:
Daniel J Klionsky Hagai Abeliovich Patrizia Agostinis Devendra K Agrawal Gjumrakch Aliev David S Askew Misuzu Baba Eric H Baehrecke Ben A Bahr Andrea Ballabio Bruce A Bamber Diane C Bassham Ettore Bergamini Xiaoning Bi Martine Biard-Piechaczyk Janice S Blum Dale E Bredesen Jeffrey L Brodsky John H Brumell Ulf T Brunk Wilfried Bursch Nadine Camougrand Eduardo Cebollero Francesco Cecconi Yingyu Chen Lih-Shen Chin Augustine Choi Charleen T Chu Jongkyeong Chung Peter G H Clarke Robert S B Clark Steven G Clarke Corinne Clavé John L Cleveland Patrice Codogno María I Colombo Ana Coto-Montes James M Cregg Ana Maria Cuervo Jayanta Debnath Francesca Demarchi Patrick B Dennis Phillip A Dennis Vojo Deretic Rodney J Devenish Federica Di Sano J Fred Dice Marian Difiglia Savithramma Dinesh-Kumar Clark W Distelhorst Mojgan Djavaheri-Mergny Frank C Dorsey Wulf Dröge Michel Dron William A Dunn Michael Duszenko N Tony Eissa Zvulun Elazar Audrey Esclatine Eeva-Liisa Eskelinen László Fésüs Kim D Finley José M Fuentes Juan Fueyo Kozo Fujisaki Brigitte Galliot Fen-Biao Gao David A Gewirtz Spencer B Gibson Antje Gohla Alfred L Goldberg Ramon Gonzalez Cristina González-Estévez Sharon Gorski Roberta A Gottlieb Dieter Häussinger You-Wen He Kim Heidenreich Joseph A Hill Maria Høyer-Hansen Xun Hu Wei-Pang Huang Akiko Iwasaki Marja Jäättelä William T Jackson Xuejun Jiang Shengkan Jin Terje Johansen Jae U Jung Motoni Kadowaki Chanhee Kang Ameeta Kelekar David H Kessel Jan A K W Kiel Hong Pyo Kim Adi Kimchi Timothy J Kinsella Kirill Kiselyov Katsuhiko Kitamoto Erwin Knecht Masaaki Komatsu Eiki Kominami Seiji Kondo Attila L Kovács Guido Kroemer Chia-Yi Kuan Rakesh Kumar Mondira Kundu Jacques Landry Marianne Laporte Weidong Le Huan-Yao Lei Michael J Lenardo Beth Levine Andrew Lieberman Kah-Leong Lim Fu-Cheng Lin Willisa Liou Leroy F Liu Gabriel Lopez-Berestein Carlos López-Otín Bo Lu Kay F Macleod Walter Malorni Wim Martinet Ken Matsuoka Josef Mautner Alfred J Meijer Alicia Meléndez Paul Michels Giovanni Miotto Wilhelm P Mistiaen Noboru Mizushima Baharia Mograbi Iryna Monastyrska Michael N Moore Paula I Moreira Yuji Moriyasu Tomasz Motyl Christian Münz Leon O Murphy Naweed I Naqvi Thomas P Neufeld Ichizo Nishino Ralph A Nixon Takeshi Noda Bernd Nürnberg Michinaga Ogawa Nancy L Oleinick Laura J Olsen Bulent Ozpolat Shoshana Paglin Glen E Palmer Issidora Papassideri Miles Parkes David H Perlmutter George Perry Mauro Piacentini Ronit Pinkas-Kramarski Mark Prescott Tassula Proikas-Cezanne Nina Raben Abdelhaq Rami Fulvio Reggiori Bärbel Rohrer David C Rubinsztein Kevin M Ryan Junichi Sadoshima Hiroshi Sakagami Yasuyoshi Sakai Marco Sandri Chihiro Sasakawa Miklós Sass Claudio Schneider Per O Seglen Oleksandr Seleverstov Jeffrey Settleman John J Shacka Irving M Shapiro Andrei Sibirny Elaine C M Silva-Zacarin Hans-Uwe Simon Cristiano Simone Anne Simonsen Mark A Smith Katharina Spanel-Borowski Vickram Srinivas Meredith Steeves Harald Stenmark Per E Stromhaug Carlos S Subauste Seiichiro Sugimoto David Sulzer Toshihiko Suzuki Michele S Swanson Ira Tabas Fumihiko Takeshita Nicholas J Talbot Zsolt Tallóczy Keiji Tanaka Kozo Tanaka Isei Tanida Graham S Taylor J Paul Taylor Alexei Terman Gianluca Tettamanti Craig B Thompson Michael Thumm Aviva M Tolkovsky Sharon A Tooze Ray Truant Lesya V Tumanovska Yasuo Uchiyama Takashi Ueno Néstor L Uzcátegui Ida van der Klei Eva C Vaquero Tibor Vellai Michael W Vogel Hong-Gang Wang Paul Webster John W Wiley Zhijun Xi Gutian Xiao Joachim Yahalom Jin-Ming Yang George Yap Xiao-Ming Yin Tamotsu Yoshimori Li Yu Zhenyu Yue Michisuke Yuzaki Olga Zabirnyk Xiaoxiang Zheng Xiongwei Zhu Russell L Deter

Autophagy 2008 Feb 21;4(2):151-75. Epub 2007 Nov 21.

Life Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109-2216, USA.

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http://www.dwalab.ca/common/pdf/cdd200944a.pdf
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2654259PMC
http://dx.doi.org/10.4161/auto.5338DOI Listing
February 2008

A stress sensitive ER membrane-association domain in Huntingtin protein defines a potential role for Huntingtin in the regulation of autophagy.

Autophagy 2008 Jan 22;4(1):91-3. Epub 2007 Oct 22.

McMaster University, Department of Biochemistry and Biomedical Sciences, Hamilton, Ontario, Canada.

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http://dx.doi.org/10.4161/auto.5201DOI Listing
January 2008

Nucleocytoplasmic trafficking and transcription effects of huntingtin in Huntington's disease.

Prog Neurobiol 2007 Nov 22;83(4):211-27. Epub 2007 Jan 22.

McMaster University, Department of Biochemistry and Biomedical Sciences, HSC4H24A, 1200 Main Street West, Hamilton, Ontario, Canada L8N3Z5.

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http://dx.doi.org/10.1016/j.pneurobio.2006.11.004DOI Listing
November 2007

Huntingtin has a membrane association signal that can modulate huntingtin aggregation, nuclear entry and toxicity.

Hum Mol Genet 2007 Nov 18;16(21):2600-15. Epub 2007 Aug 18.

Department of Biochemistry and Biomedical Sciences, McMaster University, HSC 4H24A, 1200 Main Street West, Hamilton, Ontario, Canada.

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http://dx.doi.org/10.1093/hmg/ddm217DOI Listing
November 2007

Practical three color live cell imaging by widefield microscopy.

Biol Proced Online 2006 21;8:63-8. Epub 2006 Jul 21.

Department of Biochemistry and Biomedical Sciences, McMaster University, HSC 4H24A 1200 Main Street West, Hamilton, Ontario, L8N 3Z5, Canada.

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http://dx.doi.org/10.1251/bpo119DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1523422PMC
July 2007

Regulation of SR-BI-mediated selective lipid uptake in Chinese hamster ovary-derived cells by protein kinase signaling pathways.

J Lipid Res 2007 Feb 1;48(2):405-16. Epub 2006 Nov 1.

Departments of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada.

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http://dx.doi.org/10.1194/jlr.M600326-JLR200DOI Listing
February 2007

Hypothesis: Huntingtin may function in membrane association and vesicular trafficking.

Biochem Cell Biol 2006 Dec;84(6):912-7

McMaster University. Department of Biochemistry and Biomedical Sciences. HSC4H24A, 1200 Main Street West, Hamilton, ON L8N 3Z5, Canada.

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http://dx.doi.org/10.1139/o06-181DOI Listing
December 2006

Canadian Association of Neurosciences Review: polyglutamine expansion neurodegenerative diseases.

Can J Neurol Sci 2006 Aug;33(3):278-91

Department of Biochemistry and Biomedical Sciences McMaster University, Hamilton, ON, Canada.

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http://dx.doi.org/10.1017/s031716710000514xDOI Listing
August 2006

Ataxin-7 can export from the nucleus via a conserved exportin-dependent signal.

J Biol Chem 2006 Feb 28;281(5):2730-9. Epub 2005 Nov 28.

Department of Biochemistry and Biomedical Sciences, McMaster University, HSC4H45 Hamilton, Ontario L8N3Z5 Canada.

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http://dx.doi.org/10.1074/jbc.M506751200DOI Listing
February 2006

The TagB protein in Bacillus subtilis 168 is an intracellular peripheral membrane protein that can incorporate glycerol phosphate onto a membrane-bound acceptor in vitro.

J Biol Chem 2005 Nov 2;280(44):36691-700. Epub 2005 Sep 2.

Antimicrobial Research Centre and Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario L8N 3Z5, Canada.

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http://dx.doi.org/10.1074/jbc.M507154200DOI Listing
November 2005

Inhibition of metabotropic glutamate receptor signaling by the huntingtin-binding protein optineurin.

J Biol Chem 2005 Oct 9;280(41):34840-8. Epub 2005 Aug 9.

Cell Biology Research Group, Robarts Research Institute and Department of Physiology and Pharmacology, The University of Western Ontario, London, Ontario N6A 5K8, Canada.

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http://dx.doi.org/10.1074/jbc.M504508200DOI Listing
October 2005

RNA association and nucleocytoplasmic shuttling by ataxin-1.

J Cell Sci 2005 Jan;118(Pt 1):233-42

McMaster University, HSC 4H45, Department of Biochemistry, Hamilton, Ontario, L8N 3Z5, Canada.

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http://dx.doi.org/10.1242/jcs.01611DOI Listing
January 2005

Re-expression of TSLC1 in a non-small-cell lung cancer cell line induces apoptosis and inhibits tumor growth.

Oncogene 2004 Jul;23(33):5632-42

Department of Biochemistry, McMaster University, 1200 Main Street West, Hamilton, ON, Canada L8N 3Z5.

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http://dx.doi.org/10.1038/sj.onc.1207756DOI Listing
July 2004

Huntingtin contains a highly conserved nuclear export signal.

Hum Mol Genet 2003 Jun;12(12):1393-403

Department of Biochemistry, McMaster University, Health Sciences Centre Rm 4H45, 1200 Main Street West, Hamilton, Ontario, Canada L8N 3Z5.

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http://dx.doi.org/10.1093/hmg/ddg156DOI Listing
June 2003

Live-cell nucleocytoplasmic protein shuttle assay utilizing laser confocal microscopy and FRAP.

Biotechniques 2002 Jan;32(1):80-2, 84, 86-7

McMaster University, Hamilton, ON, Canada.

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http://dx.doi.org/10.2144/02321st04DOI Listing
January 2002