Dr Ray K Iles, BSc, MSc, PhD,  - MAPDiagnostics Ltd - Founder and Director

Dr Ray K Iles

BSc, MSc, PhD,

MAPDiagnostics Ltd

Founder and Director

Ely, Cambridgeshire | United Kingdom

Main Specialties: Other

Additional Specialties: Clinical Laboratory Medicine

Dr Ray K Iles, BSc, MSc, PhD,  - MAPDiagnostics Ltd - Founder and Director

Dr Ray K Iles

BSc, MSc, PhD,

Introduction

Primary Affiliation: MAPDiagnostics Ltd - Ely, Cambridgeshire , United Kingdom

Specialties:

Additional Specialties:


View Dr Ray K Iles’s Resume / CV

Publications

26Publications

304Reads

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116PubMed Central Citations

Shotgun metabolomic profiles in maternal urine identify potential mass spectral markers of abnormal fetal biochemistry - dihydrouracil and progesterone in the metabolism of Down syndrome.

Biomed Chromatogr 2015 Aug 26;29(8):1173-83. Epub 2014 Dec 26.

Eric Leonard Kruse Foundation for Health Research, UK.

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http://dx.doi.org/10.1002/bmc.3404DOI Listing
August 2015
4 Reads
3 Citations
1.723 Impact Factor

Direct and rapid mass spectral fingerprinting of maternal urine for the detection of Down syndrome pregnancy.

Clin Proteomics 2015 24;12(1). Epub 2015 Mar 24.

MAP Diagnostics Ltd, The BioPark, Broadwater Road, Welwyn Garden City, Hertfordshire, AL7 3AX UK ; Middlesex University, Hendon, London, UK.

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http://dx.doi.org/10.1186/s12014-015-9082-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4389308PMC
April 2015
6 Reads

HILIC-MS-based shotgun metabolomic profiling of maternal urine at 9-23 weeks of gestation - establishing the baseline changes in the maternal metabolome.

Biomed Chromatogr 2015 Feb 5;29(2):240-5. Epub 2014 Jun 5.

Eric Leonard Kruse Foundation for Health Research, UK; Biomedical Sciences, Middlesex University, Hendon, NW4 4BT, UK; Manchester Institute of Biotechnology and School of Chemistry, University of Manchester, M1 7DN, UK.

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http://dx.doi.org/10.1002/bmc.3266DOI Listing
February 2015
3 Reads
2 Citations
1.723 Impact Factor

Do not just do it, do it right: urinary metabolomics--establishing clinically relevant baselines.

Biomed Chromatogr 2014 Nov 2;28(11):1491-501. Epub 2014 May 2.

Eric Leonard Kruse Foundation for Health Research, Manchester, UK; Manchester Institute of Biotechnology and School of Chemistry, University of Manchester, M1 7DN, UK.

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http://dx.doi.org/10.1002/bmc.3219DOI Listing
November 2014
2 Reads
3 Citations
1.723 Impact Factor

Direct analysis of hCGβcf glycosylation in normal and aberrant pregnancy by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry.

Int J Mol Sci 2014 Jun 5;15(6):10067-82. Epub 2014 Jun 5.

Williamson Laboratory for Molecular Oncology, St Bartholomews Hospital, London EC1A 7BE, UK.

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http://dx.doi.org/10.3390/ijms150610067DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4100140PMC
June 2014
10 Reads
1 Citation
2.862 Impact Factor

Novel insights into the expression of CGB1 & 2 genes by epithelial cancer cell lines secreting ectopic free hCGβ.

Anticancer Res 2014 May;34(5):2239-48

4550 Post Oak Place, Suite 224, Houston, TX, U.S.A.

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May 2014
6 Reads
2 Citations
1.872 Impact Factor

Single point biochemical measurement algorithm for early diagnosis of ectopic pregnancy.

Clin Biochem 2013 Sep 3;46(13-14):1257-63. Epub 2013 Jul 3.

School of Science and Technology, Middlesex University, The Burroughs, Hendon, London NW4 4BT, UK.

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http://dx.doi.org/10.1016/j.clinbiochem.2013.06.019DOI Listing
September 2013
12 Reads
1 Citation
2.230 Impact Factor

Human chorionic gonadotropin (hCG) in the secretome of cultured embryos: hyperglycosylated hCG and hCG-free beta subunit are potential markers for infertility management and treatment.

Reprod Sci 2013 Sep 25;20(9):1038-45. Epub 2013 Feb 25.

Centre for Investigative and Diagnostic Oncology, Middlesex University, The Burroughs, Hendon, London, UK.

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http://dx.doi.org/10.1177/1933719112472739DOI Listing
September 2013
27 Reads
4 Citations
2.230 Impact Factor

Stable knockdown of hCGβ mRNA expression in bladder cancer cells results in significant growth inhibition.

Anticancer Res 2013 Sep;33(9):3611-4

ELK Foundation for Health Research, An Scoil Monzaird, Crieff, Scotland, PH7 4JT, U.K.

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September 2013
2 Reads
2 Citations
1.872 Impact Factor

Differential proteolysis of insulin-like growth factor binding protein-1 (IGFBP-1) in pregnancy.

J Perinat Med 2013 May;41(3):241-9

Department of Natural Sciences Middlesex University, The Burroughs London NW4 4BT, UK.

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http://dx.doi.org/10.1515/jpm-2012-0086DOI Listing
May 2013
2 Reads
1 Citation
1.430 Impact Factor

Arsenic trioxide induces cervical cancer apoptosis, but specifically targets human papillomavirus-infected cell populations.

Anticancer Drugs 2012 Mar;23(3):280-7

Centre for Investigative and Diagnostic Oncology, Middlesex University, London, UK.

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http://dx.doi.org/10.1097/CAD.0b013e32834f1fd3DOI Listing
March 2012
4 Reads
6 Citations
1.891 Impact Factor

Gonadotropins and gonadotropin receptors--evolutional genetics, signalling mechanisms, extra gonadal function and roles in oncogenesis.

Mol Cell Endocrinol 2010 Nov 30;329(1-2):1-2. Epub 2010 Jul 30.

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http://dx.doi.org/10.1016/j.mce.2010.07.024DOI Listing
November 2010
4 Reads
4.410 Impact Factor

Estradiol, progesterone, testosterone profiles in human follicular fluid and cultured granulosa cells from luteinized pre-ovulatory follicles.

Reprod Biol Endocrinol 2010 Oct 11;8:117. Epub 2010 Oct 11.

Biomedical Sciences, School of Health and Social Science, Middlesex University, The Burroughs, NW4 4BT, UK.

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http://dx.doi.org/10.1186/1477-7827-8-117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2958979PMC
October 2010
6 Reads
12 Citations
2.410 Impact Factor

High follicular fluid adenosine levels may be pivotal in the metabolism and recycling of adenosine nucleotides in the human follicle.

Metabolism 2010 Aug 4;59(8):1145-55. Epub 2010 Jan 4.

Biomedical Sciences, School of Health and Social Science, Middlesex University, Hendon NW4 4BT, UK.

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http://dx.doi.org/10.1016/j.metabol.2009.09.037DOI Listing
August 2010
5 Reads
5 Citations
3.894 Impact Factor

Bony metastases from breast cancer - a study of foetal antigen 2 as a blood tumour marker.

World J Surg Oncol 2010 May 13;8:38. Epub 2010 May 13.

Division of Breast Surgery, University of Nottingham, Nottingham, UK.

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http://dx.doi.org/10.1186/1477-7819-8-38DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2879255PMC
May 2010
6 Reads
1.200 Impact Factor

Clinical and endocrinological changes after electro-acupuncture treatment in patients with osteoarthritis of the knee.

Pain 2009 Dec 18;147(1-3):60-6. Epub 2009 Sep 18.

Department of Physiology, Army Medical College Rawalpindi, Rawalpindi, Pakistan.

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http://dx.doi.org/10.1016/j.pain.2009.08.004DOI Listing
December 2009
3 Reads
17 Citations
5.213 Impact Factor

Towards the development of an electrochemical biosensor for hCGbeta detection.

Physiol Meas 2008 Jun 10;29(6):S241-54. Epub 2008 Jun 10.

Department of Electronic and Electrical Engineering, University College London, London, UK.

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http://dx.doi.org/10.1088/0967-3334/29/6/S21DOI Listing
June 2008
3 Reads
1.810 Impact Factor

Human granulosa-lutein cell in vitro production of progesterone, inhibin A, inhibin B, and activin A are dependent on follicular size and not the presence of the oocyte.

Fertil Steril 2008 May 6;89(5 Suppl):1406-13. Epub 2007 Aug 6.

Biomedical Sciences, Institute of Health and Social Research, School of Health and Social Science, Middlesex University, Enfield, Middlesex, United Kingdom.

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http://dx.doi.org/10.1016/j.fertnstert.2007.03.086DOI Listing
May 2008
3 Reads
4 Citations
4.590 Impact Factor

An introduction to mass spectrometry based proteomics-detection and characterization of gonadotropins and related molecules.

Mol Cell Endocrinol 2007 Jan 13;260-262:212-27. Epub 2006 Nov 13.

Department of Forensic Science & Drug Monitoring (Drug Control Centre), Kings College London, 150 Stamford Street, London SE1 9NH, UK.

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http://dx.doi.org/10.1016/j.mce.2006.02.022DOI Listing
January 2007
4 Reads
3 Citations
4.410 Impact Factor

Follicular fluid levels of inhibin A, inhibin B, and activin A levels reflect changes in follicle size but are not independent markers of the oocyte's ability to fertilize.

Fertil Steril 2006 Jun 2;85(6):1723-9. Epub 2006 May 2.

Institute of Social and Health Research, School of Health and Social Science, Middlesex University, Enfield, United Kingdom.

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http://dx.doi.org/10.1016/j.fertnstert.2005.11.058DOI Listing
June 2006
3 Reads
10 Citations
4.590 Impact Factor

Identification of placental transforming growth factor-beta and bikunin metabolites as contaminants of pharmaceutical human chorionic gonadotrophin preparations by proteomic techniques.

Mol Cell Proteomics 2005 Jul 25;4(7):984-92. Epub 2005 Apr 25.

Biomedical Sciences, Institute of Social and Health Research, Middlesex University, Enfield EN3 4SA, United Kingdom.

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http://dx.doi.org/10.1074/mcp.M500085-MCP200DOI Listing
July 2005
46 Reads
1 Citation
6.564 Impact Factor

Reduction of bladder cancer cell growth in response to hCGbeta CTP37 vaccinated mouse serum.

Oncol Res 2003 ;14(2):93-100

Williamson Laboratory, Department of Obstetrics and Gynecology, Barts and The London, Queen Mary School of Medicine, St. Bartholomews Hospital, London, UK.

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http://dx.doi.org/10.3727/000000003108748649DOI Listing
July 2004
3 Reads
4 Citations
0.920 Impact Factor

The free monomeric beta subunit of human chorionic gonadotrophin (hCG beta) and the recently identified homodimeric beta-beta subunit (hCG beta beta) both have autocrine growth effects.

Tumour Biol 2004 Jan-Apr;25(1-2):18-23

Williamson Laboratory, Department of Obstetrics and Gynecology, Bart's and the London Queen Mary School of Medicine and Dentistry, Queen Mary University of London, London, UK.

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http://dx.doi.org/10.1159/000077719DOI Listing
July 2004
7 Reads
10 Citations
2.840 Impact Factor

Human chorionic gonadotropin isoforms in the diagnosis of ectopic pregnancy.

Clin Chem 2003 Dec;49(12):2045-9

Williamson Laboratory, Department of Obstetrics and Gynaecology, Barts and The London Queen Mary School of Medicine, London EC1A 7BE, UK.

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http://dx.doi.org/10.1373/clinchem.2003.022095DOI Listing
December 2003
10 Reads
4 Citations
7.911 Impact Factor

Ectopic human chorionic gonadotropin beta secretion by epithelial tumors and human chorionic gonadotropin beta-induced apoptosis in Kaposi's sarcoma: is there a connection?

Clin Cancer Res 2003 Oct;9(13):4666-73

Williamson Laboratory for Molecular Oncology, Department of Obstetrics and Gynecology, St. Bartholomew's and the Royal London School of Medicine and Dentistry, St. Bartholomew's Hospital, West Smithfield, London EC1A 7BE, United Kingdom.

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October 2003
63 Reads
10 Citations
8.722 Impact Factor

Enhanced affinity capture MALDI-TOF MS: orientation of an immunoglobulin G using recombinant protein G.

Anal Chem 2002 Aug;74(15):3677-83

Drug Control Centre and Department of Pharmacy, King's College London, United Kingdom.

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http://dx.doi.org/10.1021/ac025558zDOI Listing
August 2002
60 Reads
11 Citations
5.640 Impact Factor