Dr. Raviprakash Tumkur Sitaram, DVM, MVSc, PhD - Umeå University - Researcher

Dr. Raviprakash Tumkur Sitaram

DVM, MVSc, PhD

Umeå University

Researcher

Umeå, Vasterbotten | Sweden

Main Specialties: Oncology

Additional Specialties: Cancer

ORCID logohttps://orcid.org/0000-0002-2391-5903

Dr. Raviprakash Tumkur Sitaram, DVM, MVSc, PhD - Umeå University - Researcher

Dr. Raviprakash Tumkur Sitaram

DVM, MVSc, PhD

Introduction

Primary Affiliation: Umeå University - Umeå, Vasterbotten , Sweden

Specialties:

Additional Specialties:

Research Interests:

Publications

12Publications

641Reads

22Profile Views

71PubMed Central Citations

Sex specific associations in genome wide association analysis of renal cell carcinoma.

Authors:
Ruhina S Laskar David C Muller Peng Li Mitchell J Machiela Yuanqing Ye Valerie Gaborieau Matthieu Foll Jonathan N Hofmann Leandro Colli Joshua N Sampson Zhaoming Wang Delphine Bacq-Daian Anne Boland Behnoush Abedi-Ardekani Geoffroy Durand Florence Le Calvez-Kelm Nivonirina Robinot Helene Blanche Egor Prokhortchouk Konstantin G Skryabin Laurie Burdett Meredith Yeager Sanja Radojevic-Skodric Slavisa Savic Lenka Foretova Ivana Holcatova Vladimir Janout Dana Mates Stefan Rascu Anush Mukeria David Zaridze Vladimir Bencko Cezary Cybulski Eleonora Fabianova Viorel Jinga Jolanta Lissowska Jan Lubinski Marie Navratilova Peter Rudnai Beata Świątkowska Simone Benhamou Geraldine Cancel-Tassin Olivier Cussenot Antonia Trichopoulou Elio Riboli Kim Overvad Salvatore Panico Borje Ljungberg Raviprakash T Sitaram Graham G Giles Roger L Milne Gianluca Severi Fiona Bruinsma Tony Fletcher Kvetoslava Koppova Susanna C Larsson Alicja Wolk Rosamonde E Banks Peter J Selby Douglas F Easton Paul Pharoah Gabriella Andreotti Laura E Beane Freeman Stella Koutros Demetrius Albanes Satu Männistö Stephanie Weinstein Peter E Clark Todd L Edwards Loren Lipworth Hallie Carol Matthew L Freedman Mark M Pomerantz Eunyoung Cho Peter Kraft Mark A Preston Kathryn M Wilson J Michael Gaziano Howard D Sesso Amanda Black Neal D Freedman Wen-Yi Huang John G Anema Richard J Kahnoski Brian R Lane Sabrina L Noyes David Petillo Bin Tean Teh Ulrike Peters Emily White Garnet L Anderson Lisa Johnson Juhua Luo Wong-Ho Chow Lee E Moore Toni K Choueiri Christopher Wood Mattias Johansson James D McKay Kevin M Brown Nathaniel Rothman Mark G Lathrop Jean-Francois Deleuze Xifeng Wu Paul Brennan Stephen J Chanock Mark P Purdue Ghislaine Scelo

Eur J Hum Genet 2019 Oct 23;27(10):1589-1598. Epub 2019 Jun 23.

International Agency for Research on Cancer (IARC), Lyon, France.

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http://dx.doi.org/10.1038/s41431-019-0455-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6777615PMC
October 2019
26 Reads
4.349 Impact Factor

The influence of obesity-related factors in the etiology of renal cell carcinoma-A mendelian randomization study.

Authors:
Mattias Johansson Robert Carreras-Torres Ghislaine Scelo Mark P Purdue Daniela Mariosa David C Muller Nicolas J Timpson Philip C Haycock Kevin M Brown Zhaoming Wang Yuanqing Ye Jonathan N Hofmann Matthieu Foll Valerie Gaborieau Mitchell J Machiela Leandro M Colli Peng Li Jean-Guillaume Garnier Helene Blanche Anne Boland Laurie Burdette Egor Prokhortchouk Konstantin G Skryabin Meredith Yeager Sanja Radojevic-Skodric Simona Ognjanovic Lenka Foretova Ivana Holcatova Vladimir Janout Dana Mates Anush Mukeriya Stefan Rascu David Zaridze Vladimir Bencko Cezary Cybulski Eleonora Fabianova Viorel Jinga Jolanta Lissowska Jan Lubinski Marie Navratilova Peter Rudnai Simone Benhamou Geraldine Cancel-Tassin Olivier Cussenot Elisabete Weiderpass Börje Ljungberg Raviprakash Tumkur Sitaram Christel Häggström Fiona Bruinsma Susan J Jordan Gianluca Severi Ingrid Winship Kristian Hveem Lars J Vatten Tony Fletcher Susanna C Larsson Alicja Wolk Rosamonde E Banks Peter J Selby Douglas F Easton Gabriella Andreotti Laura E Beane Freeman Stella Koutros Satu Männistö Stephanie Weinstein Peter E Clark Todd L Edwards Loren Lipworth Susan M Gapstur Victoria L Stevens Hallie Carol Matthew L Freedman Mark M Pomerantz Eunyoung Cho Kathryn M Wilson J Michael Gaziano Howard D Sesso Neal D Freedman Alexander S Parker Jeanette E Eckel-Passow Wen-Yi Huang Richard J Kahnoski Brian R Lane Sabrina L Noyes David Petillo Bin Tean Teh Ulrike Peters Emily White Garnet L Anderson Lisa Johnson Juhua Luo Julie Buring I-Min Lee Wong-Ho Chow Lee E Moore Timothy Eisen Marc Henrion James Larkin Poulami Barman Bradley C Leibovich Toni K Choueiri G Mark Lathrop Jean-Francois Deleuze Marc Gunter James D McKay Xifeng Wu Richard S Houlston Stephen J Chanock Caroline Relton J Brent Richards Richard M Martin George Davey Smith Paul Brennan

PLoS Med 2019 01 3;16(1):e1002724. Epub 2019 Jan 3.

International Agency for Research on Cancer (IARC), Lyon, France.

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http://dx.doi.org/10.1371/journal.pmed.1002724DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6317776PMC
January 2019
66 Reads

VHL status regulates transforming growth factor-β signaling pathways in renal cell carcinoma

Oncotarget

To evaluate the role of pVHL in the regulation of TGF-β signaling pathways in clear cell renal cell carcinoma (ccRCC) as well as in non-ccRCC; the expression of pVHL, and the TGF-β pathway components and their association with clinicopathological parameters and patient’s survival were explored. Tissue samples from 143 ccRCC and 58 non-ccRCC patients were examined by immunoblot. ccRCC cell lines were utilized for mechanistic in-vitro studies. Expression levels of pVHL were significantly lower in ccRCC compared with non-ccRCC. Non-ccRCC and ccRCC pVHL-High expressed similar levels of pVHL. Expression of the TGF-β type I receptor (ALK5) and intra-cellular domain were significantly higher in ccRCC compared with non-ccRCC. In non-ccRCC,expressions of ALK5-FL, ALK5-ICD, pSMAD2/3, and PAI-1 had no association with clinicopathological parameters and survival. In ccRCC pVHL-Low, ALK5-FL, ALK5-ICD, pSMAD2/3, and PAI-1 were significantly related with tumor stage, size, and survival. In ccRCC pVHL-High, the expression of PAI-1 was associated with stage and survival. In-vitro studies revealed that pVHL interacted with ALK5 to downregulate its expression through K48-linked poly-ubiquitination and proteasomal degradation, thus negatively controlling TGF-β induced cancer cell invasiveness. The pVHL status controls the ALK5 and can thereby regulate the TGF-β pathway, aggressiveness of tumors, and survival of the ccRCC and non-ccRCC patients.

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March 2018
86 Reads

Genetic Variants Related to Longer Telomere Length are Associated with Increased Risk of Renal Cell Carcinoma.

Authors:
Mitchell J Machiela Jonathan N Hofmann Robert Carreras-Torres Kevin M Brown Mattias Johansson Zhaoming Wang Matthieu Foll Peng Li Nathaniel Rothman Sharon A Savage Valerie Gaborieau James D McKay Yuanqing Ye Marc Henrion Fiona Bruinsma Susan Jordan Gianluca Severi Kristian Hveem Lars J Vatten Tony Fletcher Kvetoslava Koppova Susanna C Larsson Alicja Wolk Rosamonde E Banks Peter J Selby Douglas F Easton Paul Pharoah Gabriella Andreotti Laura E Beane Freeman Stella Koutros Demetrius Albanes Satu Mannisto Stephanie Weinstein Peter E Clark Todd E Edwards Loren Lipworth Susan M Gapstur Victoria L Stevens Hallie Carol Matthew L Freedman Mark M Pomerantz Eunyoung Cho Peter Kraft Mark A Preston Kathryn M Wilson J Michael Gaziano Howard S Sesso Amanda Black Neal D Freedman Wen-Yi Huang John G Anema Richard J Kahnoski Brian R Lane Sabrina L Noyes David Petillo Leandro M Colli Joshua N Sampson Celine Besse Helene Blanche Anne Boland Laurie Burdette Egor Prokhortchouk Konstantin G Skryabin Meredith Yeager Mirjana Mijuskovic Miodrag Ognjanovic Lenka Foretova Ivana Holcatova Vladimir Janout Dana Mates Anush Mukeriya Stefan Rascu David Zaridze Vladimir Bencko Cezary Cybulski Eleonora Fabianova Viorel Jinga Jolanta Lissowska Jan Lubinski Marie Navratilova Peter Rudnai Neonila Szeszenia-Dabrowska Simone Benhamou Geraldine Cancel-Tassin Olivier Cussenot H Bas Bueno-de-Mesquita Federico Canzian Eric J Duell Börje Ljungberg Raviprakash T Sitaram Ulrike Peters Emily White Garnet L Anderson Lisa Johnson Juhua Luo Julie Buring I-Min Lee Wong-Ho Chow Lee E Moore Christopher Wood Timothy Eisen James Larkin Toni K Choueiri G Mark Lathrop Bin Tean Teh Jean-Francois Deleuze Xifeng Wu Richard S Houlston Paul Brennan Stephen J Chanock Ghislaine Scelo Mark P Purdue

Eur Urol 2017 11 7;72(5):747-754. Epub 2017 Aug 7.

Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department Health and Human Services, Bethesda, MS, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S03022838173063
Publisher Site
http://dx.doi.org/10.1016/j.eururo.2017.07.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5641242PMC
November 2017
241 Reads
5 Citations
13.940 Impact Factor

Genome-wide association study identifies multiple risk loci for renal cell carcinoma.

Authors:
Ghislaine Scelo Mark P Purdue Kevin M Brown Mattias Johansson Zhaoming Wang Jeanette E Eckel-Passow Yuanqing Ye Jonathan N Hofmann Jiyeon Choi Matthieu Foll Valerie Gaborieau Mitchell J Machiela Leandro M Colli Peng Li Joshua N Sampson Behnoush Abedi-Ardekani Celine Besse Helene Blanche Anne Boland Laurie Burdette Amelie Chabrier Geoffroy Durand Florence Le Calvez-Kelm Egor Prokhortchouk Nivonirina Robinot Konstantin G Skryabin Magdalena B Wozniak Meredith Yeager Gordana Basta-Jovanovic Zoran Dzamic Lenka Foretova Ivana Holcatova Vladimir Janout Dana Mates Anush Mukeriya Stefan Rascu David Zaridze Vladimir Bencko Cezary Cybulski Eleonora Fabianova Viorel Jinga Jolanta Lissowska Jan Lubinski Marie Navratilova Peter Rudnai Neonila Szeszenia-Dabrowska Simone Benhamou Geraldine Cancel-Tassin Olivier Cussenot Laura Baglietto Heiner Boeing Kay-Tee Khaw Elisabete Weiderpass Borje Ljungberg Raviprakash T Sitaram Fiona Bruinsma Susan J Jordan Gianluca Severi Ingrid Winship Kristian Hveem Lars J Vatten Tony Fletcher Kvetoslava Koppova Susanna C Larsson Alicja Wolk Rosamonde E Banks Peter J Selby Douglas F Easton Paul Pharoah Gabriella Andreotti Laura E Beane Freeman Stella Koutros Demetrius Albanes Satu Männistö Stephanie Weinstein Peter E Clark Todd L Edwards Loren Lipworth Susan M Gapstur Victoria L Stevens Hallie Carol Matthew L Freedman Mark M Pomerantz Eunyoung Cho Peter Kraft Mark A Preston Kathryn M Wilson J Michael Gaziano Howard D Sesso Amanda Black Neal D Freedman Wen-Yi Huang John G Anema Richard J Kahnoski Brian R Lane Sabrina L Noyes David Petillo Bin Tean Teh Ulrike Peters Emily White Garnet L Anderson Lisa Johnson Juhua Luo Julie Buring I-Min Lee Wong-Ho Chow Lee E Moore Christopher Wood Timothy Eisen Marc Henrion James Larkin Poulami Barman Bradley C Leibovich Toni K Choueiri G Mark Lathrop Nathaniel Rothman Jean-Francois Deleuze James D McKay Alexander S Parker Xifeng Wu Richard S Houlston Paul Brennan Stephen J Chanock

Nat Commun 2017 06 9;8:15724. Epub 2017 Jun 9.

Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department Health and Human Services, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1038/ncomms15724DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5472706PMC
June 2017
181 Reads
4 Citations
10.742 Impact Factor

Transforming growth factor-β promotes aggressiveness and invasion of clear cell renal cell carcinoma.

Oncotarget 2016 Jun;7(24):35917-35931

Department of Surgical and Perioperative Sciences, Urology and Andrology, Umeå University, Umeå, Sweden.

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http://dx.doi.org/10.18632/oncotarget.9177DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5094972PMC
June 2016
18 Reads
5 Citations
6.360 Impact Factor

The Radiogenomic Risk Score: Construction of a Prognostic Quantitative, Noninvasive Image-based Molecular Assay for Renal Cell Carcinoma.

Radiology 2015 Oct 19;277(1):114-23. Epub 2015 Aug 19.

From the Department of Radiological Sciences, David Geffen School of Medicine at UCLA, Box 951721, CHS 17-135, 10833 LeConte Ave, Los Angeles, CA 90095-1721 (N.J., M.Z., S.B., M.D.K.); Department of Genitourinary Medical Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, Tex (E.J.); Department of Radiology, Hospital of Veterans Affairs, University of California-San Diego, San Diego, Calif (M.Z., L.A.); Scottsdale Medical Imaging, Scottsdale, Ariz (R.K.); Department of Urology, Stanford University School of Medicine, Stanford, Calif (H.Z., J.D.B.); Department of Surgical and Perioperative Sciences, Urology and Andrology, Umea Hospital, Umea, Sweden (R.T.S., B.L.); and Department of Statistics, Stanford University, Stanford, Calif (R.J.T.).

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http://dx.doi.org/10.1148/radiol.2015150800DOI Listing
October 2015
11 Reads
9 Citations
6.870 Impact Factor

TERT promoter mutations in clear cell renal cell carcinoma.

Int J Cancer 2015 May 30;136(10):2448-52. Epub 2014 Oct 30.

Division of Molecular Genetic Epidemiology, German Cancer Research Center, Heidelberg, Germany.

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http://dx.doi.org/10.1002/ijc.29279DOI Listing
May 2015
35 Reads
12 Citations
5.085 Impact Factor

Single nucleotide polymorphisms in the Wilms' tumour gene 1 in clear cell renal cell carcinoma.

PLoS One 2013 6;8(3):e58396. Epub 2013 Mar 6.

Department of Medical Biosciences, Clinical Chemistry, Umeå University, Umeå, Sweden.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0058396PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3590177PMC
September 2013
19 Reads
2 Citations
3.234 Impact Factor

Telomere length in relation to immunological parameters in patients with renal cell carcinoma.

PLoS One 2013 1;8(2):e55543. Epub 2013 Feb 1.

Department of Medical Biosciences, Pathology, Umeå University, Umeå, Sweden.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0055543PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3562315PMC
July 2013
20 Reads
6 Citations
3.234 Impact Factor

Wilms' tumour 1 can suppress hTERT gene expression and telomerase activity in clear cell renal cell carcinoma via multiple pathways.

Br J Cancer 2010 Oct 14;103(8):1255-62. Epub 2010 Sep 14.

Department of Medical Biosciences and Pathology, Umeå University, Umeå, Sweden.

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http://dx.doi.org/10.1038/sj.bjc.6605878DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2967054PMC
October 2010
10 Reads
12 Citations
4.840 Impact Factor

The PTEN regulator DJ-1 is associated with hTERT expression in clear cell renal cell carcinoma.

Int J Cancer 2009 Aug;125(4):783-90

Department of Medical Biosciences, Pathology, Umeå University, Umeå, Sweden.

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http://dx.doi.org/10.1002/ijc.24335DOI Listing
August 2009
14 Reads
16 Citations
5.085 Impact Factor

Top co-authors

Borje Ljungberg
Borje Ljungberg

Umeå University

7
Matthew L Freedman
Matthew L Freedman

Dana-Farber Cancer Institute

4
Hallie Carol
Hallie Carol

Dana-Farber Cancer Institute

4
Peter E Clark
Peter E Clark

Vanderbilt University Medical Center

4
Mark M Pomerantz
Mark M Pomerantz

Dana-Farber Cancer Institute

4
Loren Lipworth
Loren Lipworth

International Epidemiology Institute

4
Eunyoung Cho
Eunyoung Cho

Brigham and Women's Hospital and Harvard Medical School

4
Neal D Freedman
Neal D Freedman

National Cancer Institute

4
Kathryn M Wilson
Kathryn M Wilson

Harvard School of Public Health

4
Stephanie Weinstein
Stephanie Weinstein

National Cancer Institute

4