Ravindran Kumaran

Ravindran Kumaran

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Ravindran Kumaran

Ravindran Kumaran

Publications by authors named "Ravindran Kumaran"

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16Publications

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LRRK2 phosphorylates membrane-bound Rabs and is activated by GTP-bound Rab7L1 to promote recruitment to the trans-Golgi network.

Hum Mol Genet 2018 01;27(2):385-395

Department of Neurology, Center for Neurodegeneration and Experimental Therapeutics, University of Alabama at Birmingham, Birmingham, AL 35233 USA.

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http://dx.doi.org/10.1093/hmg/ddx410DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5886198PMC
January 2018

Hexokinases link DJ-1 to the PINK1/parkin pathway.

Mol Neurodegener 2017 09 29;12(1):70. Epub 2017 Sep 29.

Cell Biology and Gene Expression Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Building 35, Room 1A116, 35 Convent Drive, MSC 3707, Bethesda, MD, 20892-3707, USA.

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http://dx.doi.org/10.1186/s13024-017-0212-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5622528PMC
September 2017

The DYT6 Dystonia Protein THAP1 Regulates Myelination within the Oligodendrocyte Lineage.

Dev Cell 2017 07;42(1):52-67.e4

Department of Neurology, University of Michigan Medical School, 109 Zina Pitcher Place, Ann Arbor, MI 48109, USA; Department of Cell and Developmental Biology, University of Michigan Medical School, 109 Zina Pitcher Place, Ann Arbor, MI 48109, USA; VAAAHS, University of Michigan Medical School, University of Michigan, 109 Zina Pitcher Place, Ann Arbor, MI 48109, USA. Electronic address:

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http://dx.doi.org/10.1016/j.devcel.2017.06.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5847273PMC
July 2017

The G2385R risk factor for Parkinson's disease enhances CHIP-dependent intracellular degradation of LRRK2.

Biochem J 2017 04 24;474(9):1547-1558. Epub 2017 Apr 24.

Cell Biology and Gene Expression Section, Laboratory of Neurogenetics, National Institute on Aging, NIH, 35 Convent Drive, Room 1A-116, Bethesda, MD 20892-3707, U.S.A.

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http://dx.doi.org/10.1042/BCJ20160909DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6178381PMC
April 2017

Characterization of B-Cells in tonsils of patients diagnosed with pediatric autoimmune neuropsychiatric disorder associated streptococcus.

Int J Pediatr Otorhinolaryngol 2016 Jan 24;80:49-52. Epub 2015 Nov 24.

Department of Otolaryngology-Head & Neck Surgery Georgetown University Hospital, Washington, DC 20007, United States; Georgetown University School of Medicine, Washington, DC 20007, United States.

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http://dx.doi.org/10.1016/j.ijporl.2015.11.020DOI Listing
January 2016

Pathways to Parkinsonism Redux: convergent pathobiological mechanisms in genetics of Parkinson's disease.

Hum Mol Genet 2015 Oct 22;24(R1):R32-44. Epub 2015 Jun 22.

Cell Biology and Gene Expression Section, Laboratory of Neurogenetics, National Institute on Aging, 35 Convent Drive, Bethesda, MD 20892-3707, USA

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http://dx.doi.org/10.1093/hmg/ddv236DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4571999PMC
October 2015

The Polg Mutator Phenotype Does Not Cause Dopaminergic Neurodegeneration in DJ-1-Deficient Mice.

eNeuro 2015 Jan-Feb;2(1). Epub 2015 Mar 23.

Cell Biology and Gene Expression Section, Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health , Bethesda, Maryland 20892.

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http://dx.doi.org/10.1523/ENEURO.0075-14.2015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4586922PMC
October 2015

Phosphorylation of LRRK2 by casein kinase 1α regulates trans-Golgi clustering via differential interaction with ARHGEF7.

Nat Commun 2014 Dec 15;5:5827. Epub 2014 Dec 15.

Cell Biology and Gene Expression Section, Laboratory of Neurogenetics, National Institute on Aging, 35 Convent Drive, Bethesda, Maryland 20892-3707, USA.

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http://dx.doi.org/10.1038/ncomms6827DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4268884PMC
December 2014

Unbiased screen for interactors of leucine-rich repeat kinase 2 supports a common pathway for sporadic and familial Parkinson disease.

Proc Natl Acad Sci U S A 2014 Feb 7;111(7):2626-31. Epub 2014 Feb 7.

Cell Biology and Gene Expression Section, Computational Biology Core, Laboratory of Neurogenetics, and Molecular Genetics Section, National Institute on Aging/National Institutes of Health, Bethesda, MD 20892.

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http://dx.doi.org/10.1073/pnas.1318306111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3932908PMC
February 2014

Age-associated changes in gene expression in human brain and isolated neurons.

Neurobiol Aging 2013 Apr 21;34(4):1199-209. Epub 2012 Nov 21.

Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892-3707, USA.

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http://dx.doi.org/10.1016/j.neurobiolaging.2012.10.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3545059PMC
April 2013

Differential DJ-1 gene expression in Parkinson's disease.

Neurobiol Dis 2009 Nov 28;36(2):393-400. Epub 2009 Aug 28.

Reta Lila Weston Institute of Neurological Disease, Institute of Neurology, University College London, 1, Wakefield Street, WC1N 1PJ, UK.

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http://dx.doi.org/10.1016/j.nbd.2009.08.011DOI Listing
November 2009

TDP-43 in ubiquitinated inclusions in the inferior olives in frontotemporal lobar degeneration and in other neurodegenerative diseases: a degenerative process distinct from normal ageing.

Acta Neuropathol 2009 Sep 28;118(3):359-69. Epub 2009 Mar 28.

Clinical Neuroscience Research Group, Faculty of Medical and Human Sciences, Greater Manchester Neurosciences Centre, School of Translational Medicine, Hope Hospital, University of Manchester, Salford, M6 8HD, UK.

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http://dx.doi.org/10.1007/s00401-009-0526-zDOI Listing
September 2009

Post-transcriptional regulation of mRNA associated with DJ-1 in sporadic Parkinson disease.

Neurosci Lett 2009 Mar 6;452(1):8-11. Epub 2009 Jan 6.

Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD 20892, United States.

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http://dx.doi.org/10.1016/j.neulet.2008.12.053DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2640439PMC
March 2009

DJ-1 (PARK7) is associated with 3R and 4R tau neuronal and glial inclusions in neurodegenerative disorders.

Neurobiol Dis 2007 Oct 18;28(1):122-32. Epub 2007 Jul 18.

Reta Lila Weston Institute of Neurological Studies, Institute of Neurology, 1, Wakefield Street, WC1N 1PJ, UK.

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http://dx.doi.org/10.1016/j.nbd.2007.07.012DOI Listing
October 2007