Publications by authors named "Ravindra N Singh"

47Publications

Characteristics of circular RNAs generated by human Survival Motor Neuron genes.

Cell Signal 2020 Sep 15;73:109696. Epub 2020 Jun 15.

Department of Biomedical Sciences, Iowa State University, Ames, IA 50011, United States of America. Electronic address:

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http://dx.doi.org/10.1016/j.cellsig.2020.109696DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7387165PMC
September 2020

RNA in spinal muscular atrophy: therapeutic implications of targeting.

Expert Opin Ther Targets 2020 Aug 25;24(8):731-743. Epub 2020 Jun 25.

Department of Biomedical Sciences, Iowa State University , Ames, IA, USA.

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http://dx.doi.org/10.1080/14728222.2020.1783241DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7529864PMC
August 2020

A survey of transcripts generated by spinal muscular atrophy genes.

Biochim Biophys Acta Gene Regul Mech 2020 08 6;1863(8):194562. Epub 2020 May 6.

Department of Biomedical Science, Iowa State University, Ames, IA, 50011, United States of America. Electronic address:

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http://dx.doi.org/10.1016/j.bbagrm.2020.194562DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7302838PMC
August 2020

RNA structure and splicing regulation.

Biochim Biophys Acta Gene Regul Mech 2019 Nov - Dec;1862(11-12):194448. Epub 2019 Nov 12.

University of Kentucky, Department of Molecular and Cellular Biochemistry, College of Medicine, B159 Biomedical Biological Sciences Research Bldg. 741 South Limestone, Lexington, KY 40536, United States.

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http://dx.doi.org/10.1016/j.bbagrm.2019.194448DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6986375PMC
February 2020

More is needed to complement the available therapies of spinal muscular atrophy.

Authors:
Ravindra N Singh

Future Med Chem 2019 11 31;11(22):2873-2876. Epub 2019 Oct 31.

Department of Biomedical Science, Iowa State University, Ames, IA 50011, USA.

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http://dx.doi.org/10.4155/fmc-2019-0239DOI Listing
November 2019

How RNA structure dictates the usage of a critical exon of spinal muscular atrophy gene.

Biochim Biophys Acta Gene Regul Mech 2019 Nov - Dec;1862(11-12):194403. Epub 2019 Jul 16.

Department of Biomedical Science, Iowa State University, Ames, IA 50011, United States of America. Electronic address:

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http://dx.doi.org/10.1016/j.bbagrm.2019.07.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6875630PMC
February 2020

A novel role of U1 snRNP: Splice site selection from a distance.

Biochim Biophys Acta Gene Regul Mech 2019 06 28;1862(6):634-642. Epub 2019 Apr 28.

Department of Biomedical Sciences, Iowa State University, Ames, IA 50011, United States of America.

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http://dx.doi.org/10.1016/j.bbagrm.2019.04.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6557577PMC
June 2019

Human Survival Motor Neuron genes generate a vast repertoire of circular RNAs.

Nucleic Acids Res 2019 04;47(6):2884-2905

Iowa State University, Biomedical Sciences, Ames, IA 50011, USA.

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http://dx.doi.org/10.1093/nar/gkz034DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6451121PMC
April 2019

Pre-mRNA Splicing Modulation by Antisense Oligonucleotides.

Methods Mol Biol 2018 ;1828:415-437

Department of Biomedical Sciences, College of Veterinary Medicine, Iowa State University, Ames, IA, USA.

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http://link.springer.com/10.1007/978-1-4939-8651-4_26
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http://dx.doi.org/10.1007/978-1-4939-8651-4_26DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6195309PMC
April 2019

Mechanism of Splicing Regulation of Spinal Muscular Atrophy Genes.

Adv Neurobiol 2018 ;20:31-61

Department of Biomedical Sciences, Iowa State University, Ames, IA, USA.

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http://dx.doi.org/10.1007/978-3-319-89689-2_2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6026014PMC
October 2018

A Multilayered Control of the Human Gene Expression by Alu Elements.

Front Microbiol 2017 15;8:2252. Epub 2017 Nov 15.

Department of Biomedical Sciences, Iowa State University, Ames, IA, United States.

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http://journal.frontiersin.org/article/10.3389/fmicb.2017.02
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http://dx.doi.org/10.3389/fmicb.2017.02252DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5694776PMC
November 2017

Gender-Specific Amelioration of SMA Phenotype upon Disruption of a Deep Intronic Structure by an Oligonucleotide.

Mol Ther 2017 06 13;25(6):1328-1341. Epub 2017 Apr 13.

Department of Biomedical Sciences, Iowa State University, Ames, IA 50011, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ymthe.2017.03.036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5475250PMC
June 2017

Diverse role of survival motor neuron protein.

Biochim Biophys Acta Gene Regul Mech 2017 Mar 15;1860(3):299-315. Epub 2017 Jan 15.

Department of Biomedical Sciences, Iowa State University, Ames, IA 50011, United States.

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http://dx.doi.org/10.1016/j.bbagrm.2016.12.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5325804PMC
March 2017

A novel human-specific splice isoform alters the critical C-terminus of Survival Motor Neuron protein.

Sci Rep 2016 08 2;6:30778. Epub 2016 Aug 2.

Department of Biomedical Sciences, Iowa State University, Ames, Iowa 50011, USA.

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http://dx.doi.org/10.1038/srep30778DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4969610PMC
August 2016

Mechanistic principles of antisense targets for the treatment of spinal muscular atrophy.

Future Med Chem 2015 18;7(13):1793-808. Epub 2015 Sep 18.

Department of Biomedical Sciences, College of Veterinary Medicine, Iowa State University, Ames, IA 50011, USA.

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http://dx.doi.org/10.4155/fmc.15.101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4660980PMC
July 2016

Splicing regulation in spinal muscular atrophy by an RNA structure formed by long-distance interactions.

Ann N Y Acad Sci 2015 Apr 27;1341:176-87. Epub 2015 Feb 27.

Department of Biomedical Sciences, Iowa State University, Ames, Iowa.

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http://doi.wiley.com/10.1111/nyas.12727
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http://dx.doi.org/10.1111/nyas.12727DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4651915PMC
April 2015

Advances in therapeutic development for spinal muscular atrophy.

Future Med Chem 2014 Jun;6(9):1081-99

Department of Biomedical Sciences, Iowa State University, Ames, IA 50011, USA.

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http://dx.doi.org/10.4155/fmc.14.63DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4356243PMC
June 2014

A short antisense oligonucleotide ameliorates symptoms of severe mouse models of spinal muscular atrophy.

Mol Ther Nucleic Acids 2014 Jul 8;3:e174. Epub 2014 Jul 8.

1] Department of Pediatrics, Feinberg School of Medicine, Northwestern University, Illinois, Chicago, Illinois, USA [2] Human Molecular Genetics Program, Stanley Manne Children's Research Institute at Ann & Robert H. Lurie Children's Hospital, Chicago, Illinois, USA.

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http://dx.doi.org/10.1038/mtna.2014.23DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4121513PMC
July 2014

Antisense methods to modulate pre-mRNA splicing.

Methods Mol Biol 2014 ;1126:271-83

Department of Biomedical Sciences, College of Veterinary Medicine, Iowa State University, Ames, IA, USA.

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http://dx.doi.org/10.1007/978-1-62703-980-2_20DOI Listing
October 2014

Antisense oligonucleotide mediated therapy of spinal muscular atrophy.

Transl Neurosci 2013 Mar;4(1)

Department of Biomedical Sciences, College of Veterinary Medicine (2034 Vet Med Bld.), Iowa State University, Ames, IA 50011.

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http://dx.doi.org/10.2478/s13380-013-0109-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3832262PMC
March 2013

Spinal muscular atrophy: an update on therapeutic progress.

Biochim Biophys Acta 2013 Dec 27;1832(12):2180-90. Epub 2013 Aug 27.

Department of Biomedical Sciences, Iowa State University, Ames, IA 50011, USA.

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http://dx.doi.org/10.1016/j.bbadis.2013.08.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3825772PMC
December 2013

An intronic structure enabled by a long-distance interaction serves as a novel target for splicing correction in spinal muscular atrophy.

Nucleic Acids Res 2013 Sep 16;41(17):8144-65. Epub 2013 Jul 16.

Department of Biomedical Sciences, Iowa State University, Ames, IA 50011, USA, Department of Biochemistry, Iowa State University, Ames, IA 50011, USA, Molecular Cellular and Developmental Biology Program, Iowa State University, Ames, IA 50011, USA and Biology Program, Iowa State University, Ames, IA 50011, USA.

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http://dx.doi.org/10.1093/nar/gkt609DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3783185PMC
September 2013

A multi-exon-skipping detection assay reveals surprising diversity of splice isoforms of spinal muscular atrophy genes.

PLoS One 2012 19;7(11):e49595. Epub 2012 Nov 19.

Department of Biomedical Sciences, Iowa State University, Ames, Iowa, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0049595PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3501452PMC
May 2013

Desulfurization of dibenzothiophene (DBT) by a novel strain Lysinibacillus sphaericus DMT-7 isolated from diesel contaminated soil.

J Environ Sci (China) 2011 ;23(6):975-82

Department of Biotechnology, Modern Institute of Technology (MIT), Dhalwala, Rishikesh 249201, Uttarakhand, India.

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http://dx.doi.org/10.1016/s1001-0742(10)60504-9DOI Listing
January 2012

Alternative splicing in spinal muscular atrophy underscores the role of an intron definition model.

RNA Biol 2011 Jul-Aug;8(4):600-6. Epub 2011 Jul 1.

Department of Biomedical Sciences Iowa State University, Ames, IA, USA.

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http://dx.doi.org/10.4161/rna.8.4.16224DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3225979PMC
April 2012

TIA1 prevents skipping of a critical exon associated with spinal muscular atrophy.

Mol Cell Biol 2011 Mar 28;31(5):935-54. Epub 2010 Dec 28.

Department of Biomedical Sciences, College of Veterinary Medicine, 2034 Veterinary Medicine Bldg., Iowa State University, Ames, IA 50011, USA.

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http://dx.doi.org/10.1128/MCB.00945-10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3067828PMC
March 2011

An antisense microwalk reveals critical role of an intronic position linked to a unique long-distance interaction in pre-mRNA splicing.

RNA 2010 Jun 22;16(6):1167-81. Epub 2010 Apr 22.

Department of Biomedical Sciences, College of Veterinary Medicine, Iowa State University, Ames, Iowa 50011, USA.

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http://dx.doi.org/10.1261/rna.2154310DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2874169PMC
June 2010

A short antisense oligonucleotide masking a unique intronic motif prevents skipping of a critical exon in spinal muscular atrophy.

RNA Biol 2009 Jul-Aug;6(3):341-50. Epub 2009 Jul 14.

Department of Biomedical Sciences, Iowa State University, Ames, IA 01605, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2734876PMC
http://dx.doi.org/10.4161/rna.6.3.8723DOI Listing
November 2009

Functional characterization of alternatively spliced human SECISBP2 transcript variants.

Nucleic Acids Res 2008 Dec 12;36(22):7192-206. Epub 2008 Nov 12.

Signal Transduction Laboratory, Queensland Institute of Medical Research, Herston, Queensland, Australia.

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http://dx.doi.org/10.1093/nar/gkn829DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2602786PMC
December 2008

Evolving concepts on human SMN pre-mRNA splicing.

Authors:
Ravindra N Singh

RNA Biol 2007 Jan-Mar;4(1):7-10. Epub 2007 Jun 4.

Department of Biomedical Sciences, College of Veterinary Medicine, Iowa State University, Ames, Iowa 50011, USA.

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http://dx.doi.org/10.4161/rna.4.1.4535DOI Listing
July 2007

Unfolding the mystery of alternative splicing through a unique method of in vivo selection.

Authors:
Ravindra N Singh

Front Biosci 2007 May 1;12:3263-72. Epub 2007 May 1.

Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605-2324, USA.

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http://dx.doi.org/10.2741/2310DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7495358PMC
May 2007

Modulating role of RNA structure in alternative splicing of a critical exon in the spinal muscular atrophy genes.

Nucleic Acids Res 2007 14;35(2):371-89. Epub 2006 Dec 14.

Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605-2324, USA.

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http://dx.doi.org/10.1093/nar/gkl1050DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1802598PMC
March 2007

Association of severity of spinal muscular atrophy with the loss of NAIP gene.

Authors:
Ravindra N Singh

Neurol India 2006 Sep;54(3):246

Department of Medicine (LRB 326), University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA.

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September 2006

Splicing of a critical exon of human Survival Motor Neuron is regulated by a unique silencer element located in the last intron.

Mol Cell Biol 2006 Feb;26(4):1333-46

Department of Medicine (LRB 326), University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA.

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http://dx.doi.org/10.1128/MCB.26.4.1333-1346.2006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1367187PMC
February 2006

The regulation and regulatory activities of alternative splicing of the SMN gene.

Crit Rev Eukaryot Gene Expr 2004 ;14(4):271-85

Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605-2324, USA.

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http://dx.doi.org/10.1615/critreveukaryotgeneexpr.v14.i4.30DOI Listing
May 2005

In vivo selection reveals combinatorial controls that define a critical exon in the spinal muscular atrophy genes.

RNA 2004 Aug;10(8):1291-305

Department of Medicine (LRB 326), University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605-2324, USA.

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http://dx.doi.org/10.1261/rna.7580704DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1370618PMC
August 2004

An extended inhibitory context causes skipping of exon 7 of SMN2 in spinal muscular atrophy.

Biochem Biophys Res Commun 2004 Mar;315(2):381-8

Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605-2324, USA.

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http://dx.doi.org/10.1016/j.bbrc.2004.01.067DOI Listing
March 2004

Binding of a group II intron-encoded reverse transcriptase/maturase to its high affinity intron RNA binding site involves sequence-specific recognition and autoregulates translation.

J Mol Biol 2002 Apr;318(2):287-303

Institute for Cellular and Molecular Biology, Department of Chemistry and Biochemistry, and Section of Molecular Genetics and Microbiology, School of Biological Sciences, University of Texas at Austin, 78712, USA.

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http://dx.doi.org/10.1016/S0022-2836(02)00054-2DOI Listing
April 2002