Ravinder K Mittal

Ravinder K Mittal

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Ravinder K Mittal

Ravinder K Mittal

Publications by authors named "Ravinder K Mittal"

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78Publications

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Endoflip vs high-definition manometry in the assessment of fecal incontinence: A data-driven unsupervised comparison.

Neurogastroenterol Motil 2018 Sep 14:e13462. Epub 2018 Sep 14.

Department of Medicine, Division of Gastroenterology, University of California, LA Jolla, California.

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September 2018

Genesis of Esophageal Pressurization and Bolus Flow Patterns in Patients With Achalasia Esophagus.

Gastroenterology 2018 08 5;155(2):327-336. Epub 2018 May 5.

Department of Medicine, Division of Gastroenterology, University of California, San Diego, California. Electronic address:

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August 2018

Measuring Length Tension Function of the Anal Sphincters and Puborectalis Muscle using Functional Luminal Imaging Probe.

Am J Physiol Gastrointest Liver Physiol 2018 Aug 30. Epub 2018 Aug 30.

Medicine, University of California, San Diego, United States.

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August 2018

Cholecystokinin Induces esophageal longitudinal muscle contraction and transient lower esophageal sphincter relaxation in healthy humans.

Am J Physiol Gastrointest Liver Physiol 2018 06 14. Epub 2018 Jun 14.

Medicine, University of California, San Diego, United States.

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June 2018

Is the Lower Esophageal Sphincter Tone Related to a Gas?

Cell Mol Gastroenterol Hepatol 2018 Mar 29;5(3):239-240. Epub 2017 Dec 29.

Department of Medicine, Division of Gastroenterology, San Diego VA Health Care System, University of California, San Diego, California.

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March 2018

Age-related external anal sphincter muscle dysfunction and fibrosis: possible role of Wnt/β-catenin signaling pathways.

Am J Physiol Gastrointest Liver Physiol 2017 Dec 24;313(6):G581-G588. Epub 2017 Aug 24.

Division of Gastroenterology, Department of Medicine, Veterans Affairs San Diego Healthcare System and University of California, San Diego, California.

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December 2017

Three-Dimensional Myoarchitecture of the Lower Esophageal Sphincter and Esophageal Hiatus Using Optical Sectioning Microscopy.

Sci Rep 2017 Oct 13;7(1):13188. Epub 2017 Oct 13.

Department of Medicine, Division of Gastroenterology, University of California, La Jolla, CA, USA.

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October 2017

Functional morphology of the lower esophageal sphincter and crural diaphragm determined by three-dimensional high-resolution esophago-gastric junction pressure profile and CT imaging.

Am J Physiol Gastrointest Liver Physiol 2017 Sep 1;313(3):G212-G219. Epub 2017 Jun 1.

Department of Medicine, University of California, San Diego, California; and.

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September 2017

Visualizing the enteric nervous system using genetically engineered double reporter mice: Comparison with immunofluorescence.

PLoS One 2017 3;12(2):e0171239. Epub 2017 Feb 3.

Division of Gastroenterology, Department of Medicine, School of Medicine, University of California, San Diego, California.

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August 2017

Wnt-β Catenin Signaling Pathway: A Major Player in the Injury Induced Fibrosis and Dysfunction of the External Anal Sphincter.

Sci Rep 2017 04 19;7(1):963. Epub 2017 Apr 19.

Department of Medicine, Division of Gastroenterology, San Diego VA Health Care System & University of California, San Diego, CA, USA.

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April 2017

A Predictive Model to Identify Patients With Fecal Incontinence Based on High-Definition Anorectal Manometry.

Clin Gastroenterol Hepatol 2016 Dec 25;14(12):1788-1796.e2. Epub 2016 Jul 25.

Division of Gastroenterology, Department of Medicine, University of California, San Diego, San Diego, California. Electronic address:

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December 2016

Regulation and dysregulation of esophageal peristalsis by the integrated function of circular and longitudinal muscle layers in health and disease.

Am J Physiol Gastrointest Liver Physiol 2016 09 21;311(3):G431-43. Epub 2016 Jul 21.

Department of Medicine, Division of Gastroenterology, San Diego VA Health Care System, San Diego, California and University of California, San Diego, California

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September 2016

Esophageal Submucosal Injection of Capsaicin but Not Acid Induces Symptoms in Normal Subjects.

J Neurogastroenterol Motil 2016 Jul;22(3):436-43

Division of Gastroenterology, University of California, San Diego, San Diego, CA, USA.

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July 2016

Esophageal contractions in type 3 achalasia esophagus: simultaneous or peristaltic?

Am J Physiol Gastrointest Liver Physiol 2016 05 25;310(9):G689-95. Epub 2016 Feb 25.

Department of Medicine, Division of Gastroenterology, San Diego VA Health Care System & University of California, San Diego, California; and

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May 2016

Low esophageal mucosal blood flow in patients with nutcracker esophagus.

Am J Physiol Gastrointest Liver Physiol 2016 Mar 23;310(6):G410-6. Epub 2015 Dec 23.

Department of Medicine, Division of Gastroenterology, San Diego Veterans Affairs Health Care System, and University of California, San Diego, California

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March 2016

Circular and longitudinal muscles shortening indicates sliding patterns during peristalsis and transient lower esophageal sphincter relaxation.

Am J Physiol Gastrointest Liver Physiol 2015 Sep 4;309(5):G360-7. Epub 2015 Jun 4.

Department of Medicine, University of California San Diego, San Diego, California; and San Diego Veterans Affairs Healthcare System, San Diego, California

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September 2015

Inhibitory motor neurons of the esophageal myenteric plexus are mechanosensitive.

Am J Physiol Cell Physiol 2015 Mar 24;308(5):C405-13. Epub 2014 Dec 24.

Division of Gastroenterology, Department of Medicine, School of Medicine, University of California, San Diego, La Jolla, California; and Veterans Affairs San Diego Healthcare System, San Diego, California.

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March 2015

Esophageal function testing: beyond manometry and impedance.

Gastrointest Endosc Clin N Am 2014 Oct 1;24(4):667-85. Epub 2014 Aug 1.

Division of Gastroenterology, Department of Medicine, San Diego VA Health Care System, University of California, Gastroenterology (111D), 3350, La Jolla Village Drive, San Diego, CA 92161, USA. Electronic address:

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October 2014

Length tension function of puborectalis muscle: implications for the treatment of fecal incontinence and pelvic floor disorders.

J Neurogastroenterol Motil 2014 Oct;20(4):539-46

Pelvic Floor Function and Diseases Group, Division of Gastroenterology, University of California, San Diego, CA, USA.

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October 2014

Myoarchitectural and functional alterations in rabbit external anal sphincter muscle following experimental surgical trauma.

Am J Physiol Gastrointest Liver Physiol 2014 Aug 3;307(4):G445-51. Epub 2014 Jul 3.

Division of Gastroenterology, Department of Medicine, San Diego Veterans Affairs Health Care System; and

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August 2014

Purse-string morphology of external anal sphincter revealed by novel imaging techniques.

Am J Physiol Gastrointest Liver Physiol 2014 Mar 23;306(6):G505-14. Epub 2014 Jan 23.

Division of Gastroenterology, Department of Medicine, University of California San Diego, San Diego, California;

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March 2014

Architecture of vagal motor units controlling striated muscle of esophagus: peripheral elements patterning peristalsis?

Auton Neurosci 2013 Dec 30;179(1-2):90-8. Epub 2013 Aug 30.

Purdue University, Dept. of Psychological Sciences, West Lafayette, IN 47907-2081, United States. Electronic address:

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December 2013

Anatomical disruption and length-tension dysfunction of anal sphincter complex muscles in women with fecal incontinence.

Dis Colon Rectum 2013 Nov;56(11):1282-9

1 Department of Medicine, Division of Gastroenterology, San Diego VA Health Care System & University of California, San Diego, California 2 Department of Internal Medicine, Seoul National University Hospital Healthcare System Gangnam Center, Seoul, South Korea.

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November 2013

Esophageal sphincter device/antireflux surgery: who needs it?

Gastroenterology 2013 Sep 25;145(3):679-81. Epub 2013 Jul 25.

Department of Medicine, University of California, San Diego, CA, USA.

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September 2013

Morphological, immunocytochemical, and functional characterization of esophageal enteric neurons in primary culture.

Am J Physiol Gastrointest Liver Physiol 2013 Jul 9;305(2):G129-38. Epub 2013 May 9.

Division of Gastroenterology, Department of Medicine, School of Medicine, University of California, San Diego, CA, USA.

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July 2013

Longitudinal muscle of the esophagus: its role in esophageal health and disease.

Curr Opin Gastroenterol 2013 Jul;29(4):421-30

Department of Medicine, Division of Gastroenterology, San Diego VA Healthcare System & University of California, San Diego, California 92161, USA.

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July 2013

Longitudinal muscle dysfunction in achalasia esophagus and its relevance.

J Neurogastroenterol Motil 2013 Apr 16;19(2):126-36. Epub 2013 Apr 16.

Division of Gastroenterology, Department of Medicine, San Diego VA Health Care System and University of California, San Diego, CA, USA.

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April 2013

Role of puborectalis muscle in the genesis of urethral pressure.

J Urol 2012 Oct 17;188(4):1382-8. Epub 2012 Aug 17.

Division of Gastroenterology, Department of Medicine, University of California-San Diego and San Diego Veterans Affairs Healthcare System, San Diego, California 92161, USA.

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October 2012

Esophageal wall blood perfusion during contraction and transient lower esophageal sphincter relaxation in humans.

Am J Physiol Gastrointest Liver Physiol 2012 Sep 12;303(5):G529-35. Epub 2012 Jul 12.

Department of Medicine, Division of Gastroenterology, San Diego Veterans Affairs Health Care System and University of California, USA.

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September 2012

A novel pattern of longitudinal muscle contraction with subthreshold pharyngeal stimulus: a possible mechanism of lower esophageal sphincter relaxation.

Am J Physiol Gastrointest Liver Physiol 2012 Mar 15;302(5):G542-7. Epub 2011 Dec 15.

Division of Gastroenterology, San Diego VA Healthcare System, CA, USA.

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March 2012

Variability in the muscle composition of rat esophagus and neural pathway of lower esophageal sphincter relaxation.

Am J Physiol Gastrointest Liver Physiol 2011 Dec 1;301(6):G1014-9. Epub 2011 Sep 1.

Division of Gastroenterology, Department of Medicine, San Diego Veterans Affairs Health Care System & University of California, San Diego, California 92161, USA.

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December 2011

Effect of esophageal contraction on esophageal wall blood perfusion.

Am J Physiol Gastrointest Liver Physiol 2011 Dec 8;301(6):G1093-8. Epub 2011 Sep 8.

Department of Medicine, Division of Gastroenterology, San Diego Veterans Affairs Health Care System and University of California, San Diego, California 92161, USA.

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December 2011

Sustained improvement in the anal sphincter function following surgical plication of rabbit external anal sphincter muscle.

Dis Colon Rectum 2011 Nov;54(11):1373-80

Department of Medicine, Division of Gastroenterology, University of California, San Diego, and San Diego VA Healthcare System, San Diego, California 92161, USA.

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November 2011

Anal sphincter complex muscles defects and dysfunction in asymptomatic parous women.

Int Urogynecol J 2011 Sep 21;22(9):1143-50. Epub 2011 May 21.

The Pelvic Floor Function and Disorder Group, University of California, San Diego, CA, USA.

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September 2011

Antireflux action of Nissen fundoplication and stretch-sensitive mechanism of lower esophageal sphincter relaxation.

Gastroenterology 2011 Feb 16;140(2):442-9. Epub 2010 Oct 16.

Department of Medicine and Surgery, San Diego VA Health Care System, California 92161, USA.

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February 2011

Granulocytic sarcoma of the colon.

Clin Gastroenterol Hepatol 2011 Jan 6;9(1):A26. Epub 2010 Aug 6.

Division of Gastroenterology, University of California, San Diego, CA, USA.

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January 2011

Dynamic assessment of the vaginal high-pressure zone using high-definition manometery, 3-dimensional ultrasound, and magnetic resonance imaging of the pelvic floor muscles.

Am J Obstet Gynecol 2010 Aug 11;203(2):172.e1-8. Epub 2010 May 11.

Pelvic Floor Function and Disease Group, Division of Gastroenterology, University of California, San Diego, San Diego, CA, USA.

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August 2010

A unique esophageal motor pattern that involves longitudinal muscles is responsible for emptying in achalasia esophagus.

Gastroenterology 2010 Jul 8;139(1):102-11. Epub 2010 Apr 8.

Department of Internal Medicine, Soonchunhyang University School of Medicine, Bucheon, South Korea.

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July 2010

Genesis of multipeaked waves of the esophagus: repetitive contractions or motion artifact?

Am J Physiol Gastrointest Liver Physiol 2010 Jun 1;298(6):G927-33. Epub 2010 Apr 1.

Gastroenterology (111A San Diego VA Health Care System, 3350 La Jolla Village Dr., San Diego, CA 92161, USA.

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June 2010

Upper esophageal sphincter during transient lower esophageal sphincter relaxation: effects of reflux content and posture.

Am J Physiol Gastrointest Liver Physiol 2010 May 18;298(5):G601-7. Epub 2010 Feb 18.

University of California, San Diego, USA.

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May 2010

Mechanism of stretch-activated excitatory and inhibitory responses in the lower esophageal sphincter.

Am J Physiol Gastrointest Liver Physiol 2009 Aug 11;297(2):G397-405. Epub 2009 Jun 11.

Division of Gastroenterology, San Diego Veterans Affairs HealthCare System and University of California, San Diego, San Diego, California 92161, USA.

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August 2009

Transperineal three-dimensional ultrasound imaging for detection of anatomic defects in the anal sphincter complex muscles.

Clin Gastroenterol Hepatol 2009 Feb 16;7(2):205-11. Epub 2008 Aug 16.

The Pelvic Floor Function and Disorder Group, University of California, San Diego, California, USA.

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February 2009

Reversal of asynchrony between circular and longitudinal muscle contraction in nutcracker esophagus by atropine.

Gastroenterology 2008 Sep 12;135(3):796-802. Epub 2008 Jun 12.

Division of Gastroenterology, San Diego VA Health Care System, San Diego, California 92161, USA.

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September 2008

Pelvic floor anatomy and applied physiology.

Gastroenterol Clin North Am 2008 Sep;37(3):493-509, vii

Pelvic Floor Function and Disorder Group, Division of Gastroenterology, University of California, GI-111D, San Diego VA Health Care Center, 3350 La Jolla Village Drive, San Diego, CA 92161, USA.

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September 2008

Length-tension relationship of the external anal sphincter muscle: implications for the anal canal function.

Am J Physiol Gastrointest Liver Physiol 2008 Aug 3;295(2):G367-73. Epub 2008 Jul 3.

Department of Medicine, Division of Gastroenterology, University of California, San Diego and San Diego Veterans Affairs Healthcare System, San Diego, California 92161, USA.

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August 2008

Closure mechanism of the anal canal in women: assessed by three-dimensional ultrasound imaging.

Dis Colon Rectum 2008 Jun 11;51(6):932-9. Epub 2008 Mar 11.

Division of Gastroenterology, Pelvic Floor Function and Diseases Group, University of California, San Diego, California 92161, USA.

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June 2008

A unique longitudinal muscle contraction pattern associated with transient lower esophageal sphincter relaxation.

Gastroenterology 2008 May 17;134(5):1322-31. Epub 2008 Feb 17.

Division of Gastroenterology, San Diego VA Health Care System and University of California, San Diego, California.

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May 2008

Cholinergic stimulation induces asynchrony between the circular and longitudinal muscle contraction during esophageal peristalsis.

Am J Physiol Gastrointest Liver Physiol 2008 Mar 10;294(3):G694-8. Epub 2008 Jan 10.

Division of Gastroenterology, VA Medical Center, San Diego, CA 92161, USA.

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March 2008

Distension during gastroesophageal reflux: effects of acid inhibition and correlation with symptoms.

Am J Physiol Gastrointest Liver Physiol 2007 Aug 7;293(2):G469-74. Epub 2007 Jun 7.

Division of Gastroenterology, San Diego Veterans Affairs Health Care System and University of California, San Diego, California 92161, USA.

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August 2007

Vaginal high-pressure zone assessed by dynamic 3-dimensional ultrasound images of the pelvic floor.

Am J Obstet Gynecol 2007 Jul;197(1):52.e1-7

Pelvic Floor Function and Disorder Group, University of California, San Diego, School of Medicine, San Diego, CA, USA.

View Article
July 2007

The reliability of puborectalis muscle measurements with 3-dimensional ultrasound imaging.

Am J Obstet Gynecol 2007 Jul;197(1):68.e1-6

Pelvic Floor Function and Disorder Group, University of California, San Diego, School of Medicine, San Diego, CA, USA.

View Article
July 2007

Effects of pelvic floor muscle contraction on anal canal pressure.

Am J Physiol Gastrointest Liver Physiol 2007 Feb 5;292(2):G565-71. Epub 2006 Oct 5.

Univ of California San Diego, La Jolla, CA 92161, USA.

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February 2007

Axial stretch: A novel mechanism of the lower esophageal sphincter relaxation.

Am J Physiol Gastrointest Liver Physiol 2007 Jan 5;292(1):G329-34. Epub 2006 Oct 5.

Division of Gastroenterology, San Diego VA HealthCare System, 3350 La Jolla Village Dr., San Diego, CA 92161, USA.

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January 2007

Prevalence of increased esophageal muscle thickness in patients with esophageal symptoms.

Am J Gastroenterol 2007 Jan;102(1):137-45

Division of Gastroenterology, University of California, San Diego, San Diego VA HealthCare System, San Diego, California 92161, USA.

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January 2007

Esophageal motor disorders: recent advances.

Curr Opin Gastroenterol 2006 Jul;22(4):417-22

Division of Gastroenterology, San Diego VA Medical Center and University of California San Diego, San Diego, California, USA.

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July 2006

Common cavity pressure during gastroesophageal reflux: reassessment using simultaneous pressure, impedance, and ultrasound imaging.

Am J Physiol Gastrointest Liver Physiol 2006 Jun 26;290(6):G1149-56. Epub 2006 Jan 26.

Division of Gastroenterology, University of California, San Diego, 92161, USA.

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June 2006

Functional correlates of anal canal anatomy: puborectalis muscle and anal canal pressure.

Am J Gastroenterol 2006 May;101(5):1092-7

The Pelvic Floor Function and Disease Group, University of California, San Diego, La Jolla 92161, USA.

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May 2006

Synchrony between circular and longitudinal muscle contractions during peristalsis in normal subjects.

Am J Physiol Gastrointest Liver Physiol 2006 Mar 6;290(3):G431-8. Epub 2005 Oct 6.

Division of Gastroenterology, University of California, and San Diego Veterans Affairs Medical Center, San Diego, CA 92161, USA.

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March 2006

Evidence for the innervation of pelvic floor muscles by the pudendal nerve.

Obstet Gynecol 2005 Oct;106(4):774-81

Departments of Reproductive Medicine, Internal Medicine, Radiology, and Neurology, The Pelvic Floor Function and Disorder Group, University of California, San Diego, San Diego, California 92161, USA.

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October 2005

The vaginal pressure profile.

Neurourol Urodyn 2005 ;24(3):243-7

Department of Reproductive Medicine, Internal Medicine and Radiology, Division of Female Pelvic Medicine and Reconstructive Surgery, The Pelvic Floor Function and Disorder Group, University of California, San Diego, California 92037, USA.

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June 2005

Ultrasound system to measure esophageal varix pressure: an in vitro validation study.

Am J Physiol Gastrointest Liver Physiol 2005 May 30;288(5):G914-9. Epub 2004 Dec 30.

Division of Gastroenterology 111D, Veterans Affairs Medical Center, University of California, San Diego, 3350 La Jolla Village Drive, San Diego, California 92161, USA.

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May 2005

Crural diaphragm inhibition during esophageal distension correlates with contraction of the esophageal longitudinal muscle in cats.

Am J Physiol Gastrointest Liver Physiol 2005 May 30;288(5):G927-32. Epub 2004 Dec 30.

Department of Gastroenterology, University of California San Diego, 3350 La Jolla Village Dr., La Jolla, California 92161, USA.

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May 2005

Motor and sensory function of the esophagus: revelations through ultrasound imaging.

J Clin Gastroenterol 2005 Apr;39(4 Suppl 2):S42-8

Department of Medicine University of California, San Diego and San Diego VA Medical Center, San Diego, CA 92161, USA.

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April 2005

Sensory and motor function of the esophagus: lessons from ultrasound imaging.

Gastroenterology 2005 Feb;128(2):487-97

Department of Medicine, University of California, San Diego, CA 92161, USA.

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February 2005

Symptom hypersensitivity to acid infusion is associated with hypersensitivity of esophageal contractility.

Am J Physiol Gastrointest Liver Physiol 2004 Jul 19;287(1):G65-71. Epub 2004 Feb 19.

Section of Gastroenterology 111D, University of California-San Diego, 3350 La Jolla Village Drive, San Diego, CA 92161, USA.

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July 2004

Hypertrophy of the muscularis propria of the lower esophageal sphincter and the body of the esophagus in patients with primary motility disorders of the esophagus.

Am J Gastroenterol 2003 Aug;98(8):1705-12

Division of Gastroenterology, San Diego Veterans Affairs Medical Center, San Diego, California 92161, USA.

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August 2003

Measuring esophageal distention by high-frequency intraluminal ultrasound probe.

Am J Med 2003 Aug;115 Suppl 3A:130S-136S

Division of Gastroenterology, San Diego VA Medical Center, University of California-San Diego, 92161, USA.

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August 2003

Effect of atropine on the biomechanical properties of the oesophageal wall in humans.

J Physiol 2003 Mar 10;547(Pt 2):621-8. Epub 2003 Jan 10.

Division of Gastroenterology, VA Medical Center, University of California, San Diego, CA 92161, USA.

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March 2003

Pathophysiology of gastroesophageal reflux: motility factors.

J Gastroenterol 2003 Mar;38 Suppl 15:7-12

Division of Gastroenterology, 111D, Veterans Affairs Medical Center, San Diego, 3350 La Jolla Village Drive, San Diego, CA 92161, USA.

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March 2003

Baclofen blocks LES relaxation and crural diaphragm inhibition by esophageal and gastric distension in cats.

Am J Physiol Gastrointest Liver Physiol 2002 Dec 1;283(6):G1276-81. Epub 2002 May 1.

Division of Gastroenterology, San Diego Veterans Affairs Medical Center and University of California San Diego, San Diego, California 92161, USA.

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December 2002

Assessment of relationship between acid reflux and heartburn using receiver operating characteristic curves.

Gastroenterol Clin North Am 2002 Dec;31(4 Suppl):S45-58

University of California San Diego and San Diego Veterans Affairs Medical Center, San Diego, CA 92161, USA.

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December 2002

Measuring esophageal distension by high-frequency intraluminal ultrasound probe.

Am J Physiol Gastrointest Liver Physiol 2002 Oct;283(4):G886-92

Division of Gastroenterology, Veterans Affairs Medical Center, University of California, San Diego, San Diego, California 92161, USA.

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October 2002

Relationship between esophageal muscle thickness and intraluminal pressure in patients with esophageal spasm.

Am J Physiol Gastrointest Liver Physiol 2002 Jun;282(6):G1016-23

Division of Gastroenterology, University of California San Diego, San Diego Veterans Affairs Medical Center, San Diego 92161, USA.

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June 2002

A novel ultrasound technique to study the biomechanics of the human esophagus in vivo.

Am J Physiol Gastrointest Liver Physiol 2002 May;282(5):G785-93

Division of Gastroenterology, Veterans Affairs Medical Center, University of California, San Diego, California 92161, USA.

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May 2002