Ravinder Abrol

Ravinder Abrol

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Ravinder Abrol

Ravinder Abrol

Publications by authors named "Ravinder Abrol"

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Understanding G Protein Selectivity of Muscarinic Acetylcholine Receptors Using Computational Methods.

Int J Mol Sci 2019 Oct 24;20(21). Epub 2019 Oct 24.

Department of Chemistry and Biochemistry, California State University, Northridge, CA 91330, USA.

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http://dx.doi.org/10.3390/ijms20215290DOI Listing
October 2019

A beetle antifreeze protein protects lactate dehydrogenase under freeze-thawing.

Int J Biol Macromol 2019 Sep 19;136:1153-1160. Epub 2019 Jun 19.

Department of Chemistry and Biochemistry, California State University Los Angeles, Los Angeles, CA 90032, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ijbiomac.2019.06.067DOI Listing
September 2019

Chiral Graphs: Reduced Representations of Ligand Scaffolds for Stereoselective Biomolecular Recognition, Drug Design, and Enhanced Exploration of Chemical Structure Space.

ChemMedChem 2019 Apr 21;14(8):798-809. Epub 2019 Mar 21.

Department of Chemistry and Biochemistry, College of Science and Mathematics, California State University, Northridge, CA, 91330, USA.

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http://dx.doi.org/10.1002/cmdc.201800761DOI Listing
April 2019

Identifying multiple active conformations in the G protein-coupled receptor activation landscape using computational methods.

Methods Cell Biol 2017 11;142:173-186. Epub 2017 Sep 11.

California State University, Northridge, CA, United States. Electronic address:

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http://dx.doi.org/10.1016/bs.mcb.2017.07.009DOI Listing
May 2018

The 3D Structure of Human DP Prostaglandin G-Protein-Coupled Receptor Bound to Cyclopentanoindole Antagonist, Predicted Using the DuplexBiHelix Modification of the GEnSeMBLE Method.

J Chem Theory Comput 2018 Mar 20;14(3):1624-1642. Epub 2018 Feb 20.

Materials and Process Simulation Center (139-74) , California Institute of Technology , 1200 E. California Blvd. , Pasadena , California 91125 , United States.

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http://dx.doi.org/10.1021/acs.jctc.7b00842DOI Listing
March 2018

Predicting glycosaminoglycan surface protein interactions and implications for studying axonal growth.

Proc Natl Acad Sci U S A 2017 12 11;114(52):13697-13702. Epub 2017 Dec 11.

Materials and Process Simulation Center, California Institute of Technology, Pasadena, CA 91125;

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http://dx.doi.org/10.1073/pnas.1715093115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5748211PMC
December 2017

Activation mechanism of the G protein-coupled sweet receptor heterodimer with sweeteners and allosteric agonists.

Proc Natl Acad Sci U S A 2017 03 22;114(10):2568-2573. Epub 2017 Feb 22.

Cargill Global Food Research, Wayzata, MN 55391.

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http://dx.doi.org/10.1073/pnas.1700001114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5347580PMC
March 2017

A bitter pill for type 2 diabetes? The activation of bitter taste receptor TAS2R38 can stimulate GLP-1 release from enteroendocrine L-cells.

Biochem Biophys Res Commun 2016 07 18;475(3):295-300. Epub 2016 May 18.

Departments of Biomedical Sciences and Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA; David Geffen School of Medicine, University of California, Los Angeles, CA, USA; Materials and Process Simulation Center, California Institute of Technology, Pasadena, CA, USA; GIRx Metabolics Inc., Los Angeles, CA, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bbrc.2016.04.149DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4918516PMC
July 2016

Conformational and Thermodynamic Landscape of GPCR Activation from Theory and Computation.

Biophys J 2016 Jun;110(12):2618-2629

Materials and Process Simulation Center, California Institute of Technology, Pasadena, California; Department of Biomedical Sciences and Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California. Electronic address:

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http://dx.doi.org/10.1016/j.bpj.2016.04.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4919603PMC
June 2016

Structure-Based Sequence Alignment of the Transmembrane Domains of All Human GPCRs: Phylogenetic, Structural and Functional Implications.

PLoS Comput Biol 2016 Mar 30;12(3):e1004805. Epub 2016 Mar 30.

Materials and Process Simulation Center, California Institute of Technology, Pasadena, California, United States of America.

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http://dx.doi.org/10.1371/journal.pcbi.1004805DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4814114PMC
March 2016

Computational Prediction and Biochemical Analyses of New Inverse Agonists for the CB1 Receptor.

J Chem Inf Model 2016 Jan 5;56(1):201-12. Epub 2016 Jan 5.

Materials and Process Simulation Center, Division of Chemistry and Chemical Engineering, California Institute of Technology , Pasadena, California 91125, United States.

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http://dx.doi.org/10.1021/acs.jcim.5b00581DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4863456PMC
January 2016

The predicted ensemble of low-energy conformations of human somatostatin receptor subtype 5 and the binding of antagonists.

ChemMedChem 2015 Apr 13;10(4):650-61. Epub 2015 Mar 13.

Materials & Process Simulation Center (MC 139-74), California Institute of Technology, Pasadena, CA 91125 (USA).

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http://dx.doi.org/10.1002/cmdc.201500023DOI Listing
April 2015

Low-frequency and rare exome chip variants associate with fasting glucose and type 2 diabetes susceptibility.

Authors:
Jennifer Wessel Audrey Y Chu Sara M Willems Shuai Wang Hanieh Yaghootkar Jennifer A Brody Marco Dauriz Marie-France Hivert Sridharan Raghavan Leonard Lipovich Bertha Hidalgo Keolu Fox Jennifer E Huffman Ping An Yingchang Lu Laura J Rasmussen-Torvik Niels Grarup Margaret G Ehm Li Li Abigail S Baldridge Alena Stančáková Ravinder Abrol Céline Besse Anne Boland Jette Bork-Jensen Myriam Fornage Daniel F Freitag Melissa E Garcia Xiuqing Guo Kazuo Hara Aaron Isaacs Johanna Jakobsdottir Leslie A Lange Jill C Layton Man Li Jing Hua Zhao Karina Meidtner Alanna C Morrison Mike A Nalls Marjolein J Peters Maria Sabater-Lleal Claudia Schurmann Angela Silveira Albert V Smith Lorraine Southam Marcus H Stoiber Rona J Strawbridge Kent D Taylor Tibor V Varga Kristine H Allin Najaf Amin Jennifer L Aponte Tin Aung Caterina Barbieri Nathan A Bihlmeyer Michael Boehnke Cristina Bombieri Donald W Bowden Sean M Burns Yuning Chen Yii-DerI Chen Ching-Yu Cheng Adolfo Correa Jacek Czajkowski Abbas Dehghan Georg B Ehret Gudny Eiriksdottir Stefan A Escher Aliki-Eleni Farmaki Mattias Frånberg Giovanni Gambaro Franco Giulianini William A Goddard Anuj Goel Omri Gottesman Megan L Grove Stefan Gustafsson Yang Hai Göran Hallmans Jiyoung Heo Per Hoffmann Mohammad K Ikram Richard A Jensen Marit E Jørgensen Torben Jørgensen Maria Karaleftheri Chiea C Khor Andrea Kirkpatrick Aldi T Kraja Johanna Kuusisto Ethan M Lange I T Lee Wen-Jane Lee Aaron Leong Jiemin Liao Chunyu Liu Yongmei Liu Cecilia M Lindgren Allan Linneberg Giovanni Malerba Vasiliki Mamakou Eirini Marouli Nisa M Maruthur Angela Matchan Roberta McKean-Cowdin Olga McLeod Ginger A Metcalf Karen L Mohlke Donna M Muzny Ioanna Ntalla Nicholette D Palmer Dorota Pasko Andreas Peter Nigel W Rayner Frida Renström Ken Rice Cinzia F Sala Bengt Sennblad Ioannis Serafetinidis Jennifer A Smith Nicole Soranzo Elizabeth K Speliotes Eli A Stahl Kathleen Stirrups Nikos Tentolouris Anastasia Thanopoulou Mina Torres Michela Traglia Emmanouil Tsafantakis Sundas Javad Lisa R Yanek Eleni Zengini Diane M Becker Joshua C Bis James B Brown L Adrienne Cupples Torben Hansen Erik Ingelsson Andrew J Karter Carlos Lorenzo Rasika A Mathias Jill M Norris Gina M Peloso Wayne H-H Sheu Daniela Toniolo Dhananjay Vaidya Rohit Varma Lynne E Wagenknecht Heiner Boeing Erwin P Bottinger George Dedoussis Panos Deloukas Ele Ferrannini Oscar H Franco Paul W Franks Richard A Gibbs Vilmundur Gudnason Anders Hamsten Tamara B Harris Andrew T Hattersley Caroline Hayward Albert Hofman Jan-Håkan Jansson Claudia Langenberg Lenore J Launer Daniel Levy Ben A Oostra Christopher J O'Donnell Stephen O'Rahilly Sandosh Padmanabhan James S Pankow Ozren Polasek Michael A Province Stephen S Rich Paul M Ridker Igor Rudan Matthias B Schulze Blair H Smith André G Uitterlinden Mark Walker Hugh Watkins Tien Y Wong Eleftheria Zeggini Markku Laakso Ingrid B Borecki Daniel I Chasman Oluf Pedersen Bruce M Psaty E Shyong Tai Cornelia M van Duijn Nicholas J Wareham Dawn M Waterworth Eric Boerwinkle W H Linda Kao Jose C Florez Ruth J F Loos James G Wilson Timothy M Frayling David S Siscovick Josée Dupuis Jerome I Rotter James B Meigs Robert A Scott Mark O Goodarzi

Nat Commun 2015 Jan 29;6:5897. Epub 2015 Jan 29.

1] Department of Medicine and Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California 90048, USA [2] Division of Endocrinology, Diabetes and Metabolism, Cedars-Sinai Medical Center, Los Angeles, California 90048, USA.

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http://dx.doi.org/10.1038/ncomms6897DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4311266PMC
January 2015

The interaction of N-glycans in Fcγ receptor I α-chain with Escherichia coli K1 outer membrane protein A for entry into macrophages: experimental and computational analysis.

J Biol Chem 2014 Nov 17;289(45):30937-49. Epub 2014 Sep 17.

From the Division of Infectious Diseases and the Department of Pediatrics and the Department of Surgery, Children's Hospital Los Angeles, University of Southern California, Los Angeles, California 90027,

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http://dx.doi.org/10.1074/jbc.M114.599407DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4223301PMC
November 2014

Down-regulation of pancreatic and duodenal homeobox-1 by somatostatin receptor subtype 5: a novel mechanism for inhibition of cellular proliferation and insulin secretion by somatostatin.

Front Physiol 2014 25;5:226. Epub 2014 Jun 25.

Division of General Surgery, Department of Surgery, David Geffen School of Medicine at University of California Los Angeles, CA, USA ; CURE: Digestive Disease Research Center, David Geffen School of Medicine at University of California Los Angeles, CA, USA.

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http://dx.doi.org/10.3389/fphys.2014.00226DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4069483PMC
July 2014

SuperBiHelix method for predicting the pleiotropic ensemble of G-protein-coupled receptor conformations.

Proc Natl Acad Sci U S A 2014 Jan 16;111(1):E72-8. Epub 2013 Dec 16.

Materials and Process Simulation Center, California Institute of Technology, Pasadena, CA 91125.

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http://dx.doi.org/10.1073/pnas.1321233111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3890820PMC
January 2014

Conformational ensemble view of G protein-coupled receptors and the effect of mutations and ligand binding.

Methods Enzymol 2013 ;520:31-48

Materials and Process Simulation Center, California Institute of Technology, Pasadena, California, USA.

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http://dx.doi.org/10.1016/B978-0-12-391861-1.00002-2DOI Listing
June 2013

The glove-like structure of the conserved membrane protein TatC provides insight into signal sequence recognition in twin-arginine translocation.

Structure 2013 May 11;21(5):777-88. Epub 2013 Apr 11.

Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, USA.

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http://dx.doi.org/10.1016/j.str.2013.03.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3653977PMC
May 2013

Structure prediction of G protein-coupled receptors and their ensemble of functionally important conformations.

Methods Mol Biol 2012 ;914:237-54

Materials and Process Simulation Center, MC, California Institute of Technology, Pasadena, CA, USA.

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http://dx.doi.org/10.1007/978-1-62703-023-6_14DOI Listing
January 2013

Molecular basis for dramatic changes in cannabinoid CB1 G protein-coupled receptor activation upon single and double point mutations.

Protein Sci 2013 Jan;22(1):101-13

Division of Chemistry and Chemical Engineering, Materials and Process Simulation Center, MC 139-74, California Institute of Technology, Pasadena, California 91125, USA.

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http://dx.doi.org/10.1002/pro.2192DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3575865PMC
January 2013

Predicted structure of agonist-bound glucagon-like peptide 1 receptor, a class B G protein-coupled receptor.

Proc Natl Acad Sci U S A 2012 Dec 19;109(49):19988-93. Epub 2012 Nov 19.

Materials and Process Simulation Center 139-74, California Institute of Technology, Pasadena, CA 91125, USA.

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http://dx.doi.org/10.1073/pnas.1218051109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3523846PMC
December 2012

Identification and characterization of an activating F229V substitution in the V2 vasopressin receptor in an infant with NSIAD.

J Am Soc Nephrol 2012 Oct 6;23(10):1635-40. Epub 2012 Sep 6.

Institute for Research in Immunology and Cancer, Université de Montréal, C.P. 6128 Succursale Centre-Ville, Montréal, Québec, Canada.

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http://www.jasn.org/cgi/doi/10.1681/ASN.2012010077
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http://dx.doi.org/10.1681/ASN.2012010077DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3458462PMC
October 2012

3D structure prediction of TAS2R38 bitter receptors bound to agonists phenylthiocarbamide (PTC) and 6-n-propylthiouracil (PROP).

J Chem Inf Model 2012 Jul 13;52(7):1875-85. Epub 2012 Jul 13.

Materials and Process Simulation Center (MC-139-74), California Institute of Technology, 1200 E. California Boulevard, Pasadena, California 91125, United States.

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http://dx.doi.org/10.1021/ci300133aDOI Listing
July 2012

Molecular basis for the interplay of apoptosis and proliferation mediated by Bcl-xL:Bim interactions in pancreatic cancer cells.

Biochem Biophys Res Commun 2012 Jun 16;422(4):596-601. Epub 2012 May 16.

Materials and Process Simulation Center, Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, CA 91125, USA.

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http://dx.doi.org/10.1016/j.bbrc.2012.05.032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4620986PMC
June 2012

Bihelix: Towards de novo structure prediction of an ensemble of G-protein coupled receptor conformations.

Proteins 2012 Feb 15;80(2):505-18. Epub 2011 Dec 15.

Materials and Process Simulation Center (MC 139-74), Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125.

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http://doi.wiley.com/10.1002/prot.23216
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http://dx.doi.org/10.1002/prot.23216DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3310341PMC
February 2012

Structure-based prediction of subtype selectivity of histamine H3 receptor selective antagonists in clinical trials.

J Chem Inf Model 2011 Dec 16;51(12):3262-74. Epub 2011 Nov 16.

Materials and Process Simulation Center (MC139-74), California Institute of Technology, 1200 E. California Blvd., Pasadena, California 91125, USA.

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http://dx.doi.org/10.1021/ci200435bDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3246544PMC
December 2011

Characterizing and predicting the functional and conformational diversity of seven-transmembrane proteins.

Methods 2011 Dec 17;55(4):405-14. Epub 2011 Dec 17.

Materials and Process Simulation Center (MC 139-74), California Institute of Technology, 1200 E California Blvd, Pasadena, CA 91125, United States.

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http://dx.doi.org/10.1016/j.ymeth.2011.12.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3286597PMC
December 2011

Novel purine-based fluoroaryl-1,2,3-triazoles as neuroprotecting agents: synthesis, neuronal cell culture investigations, and CDK5 docking studies.

Bioorg Med Chem Lett 2011 Jul 14;21(13):3957-61. Epub 2011 May 14.

Department of Chemistry, Missouri University of Science and Technology, Rolla, MO 65409, United States.

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http://dx.doi.org/10.1016/j.bmcl.2011.05.019DOI Listing
July 2011

Predicted structures of agonist and antagonist bound complexes of adenosine A3 receptor.

Proteins 2011 Jun 12;79(6):1878-97. Epub 2011 Apr 12.

Division of Chemistry and Chemical Engineering, Materials and Process Simulation Center MC139-74, California Institute of Technology, Pasadena, California 91125, USA.

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http://dx.doi.org/10.1002/prot.23012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3092833PMC
June 2011

Elucidating glycosaminoglycan-protein-protein interactions using carbohydrate microarray and computational approaches.

Proc Natl Acad Sci U S A 2011 Jun 31;108(24):9747-52. Epub 2011 May 31.

Division of Chemistry and Chemical Engineering, California Institute of Technology and Howard Hughes Medical Institute, 1200 East California Boulevard, Pasadena, CA 91125, USA.

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http://dx.doi.org/10.1073/pnas.1102962108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3116396PMC
June 2011

Predicted structures and dynamics for agonists and antagonists bound to serotonin 5-HT2B and 5-HT2C receptors.

J Chem Inf Model 2011 Feb 7;51(2):420-33. Epub 2011 Feb 7.

Materials and Process Simulation Center, California Institute of Technology, Pasadena, California 91125, USA.

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http://dx.doi.org/10.1021/ci100375bDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3070210PMC
February 2011

Predicted 3D structures for adenosine receptors bound to ligands: comparison to the crystal structure.

J Struct Biol 2010 Apr 15;170(1):10-20. Epub 2010 Jan 15.

Materials and Process Simulation Center (MC139-74), California Institute of Technology, 1200 E. California Blvd., Pasadena, CA 91125, USA.

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http://dx.doi.org/10.1016/j.jsb.2010.01.001DOI Listing
April 2010

Rottlerin stimulates apoptosis in pancreatic cancer cells through interactions with proteins of the Bcl-2 family.

Am J Physiol Gastrointest Liver Physiol 2010 Jan 17;298(1):G63-73. Epub 2009 Sep 17.

Veterans Affairs Greater Los Angeles Healthcare System, Departments of Medicine, David Geffen School of Medicine, University of California, Los Angeles, California, USA.

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http://dx.doi.org/10.1152/ajpgi.00257.2009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2806098PMC
January 2010

Nonadiabatic effects in the H + H2 exchange reaction: accurate quantum dynamics calculations at a state-to-state level.

J Chem Phys 2009 Apr;130(14):144301

State Key Laboratory of Molecular Reaction Dynamics, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China.

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http://dx.doi.org/10.1063/1.3089724DOI Listing
April 2009

3-Dimensional structures of G protein-coupled receptors and binding sites of agonists and antagonists.

J Nutr 2007 06;137(6 Suppl 1):1528S-1538S; discussion 1548S

Materials and Process Simulation Center, Beckman Institute, California Institute of Technology, Pasadena, CA 91125, USA.

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http://dx.doi.org/10.1093/jn/137.6.1528SDOI Listing
June 2007

Biological chiral recognition: the substrate's perspective.

Chirality 2005 ;17 Suppl:S30-9

Department of Molecular Biology, The Scripps Research Institute, La Jolla, California 92037, USA.

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http://dx.doi.org/10.1002/chir.20108DOI Listing
September 2005

Towards a general model for protein-substrate stereoselectivity.

Protein Sci 2002 Jun;11(6):1330-9

Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, USA.

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http://doi.wiley.com/10.1110/ps.3280102
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2373627PMC
http://dx.doi.org/10.1110/ps.3280102DOI Listing
June 2002