Dr. Ravikiran S Yedidi, PhD - Institute for Stem Cell Biology and Regenerative Medicine - Team Leader

Dr. Ravikiran S Yedidi

PhD

Institute for Stem Cell Biology and Regenerative Medicine

Team Leader

Bangalore, Karnataka | India

Additional Specialties: Structural Biology

ORCID logohttps://orcid.org/0000-0003-2755-1307

Dr. Ravikiran S Yedidi, PhD - Institute for Stem Cell Biology and Regenerative Medicine - Team Leader

Dr. Ravikiran S Yedidi

PhD

Introduction

Primary Affiliation: Institute for Stem Cell Biology and Regenerative Medicine - Bangalore, Karnataka , India

Additional Specialties:

Research Interests:

Education

May 2009
Wayne State University, Detroit, MI. USA
PhD
Structure-based drug design
Jul 2004 - Mar 2009
Wayne State University School of Medicine
Ph.D.
Biochemistry
May 2003
Wayne State University, Detroit, MI. USA
MS
Molecular Biotechnology
Sep 2000 - Apr 2003
Wayne State University
M.S.
Biological Sciences
Sep 1998 - May 2000
Andhra University College of Science and Technology
M.Sc.
Biotechnology
May 2000
Andhra University, India
MSc
Biotechnology
May 1998
Andhra University, India
BSc
Biology
Jul 1995 - Apr 1998
Andhra University
B.Sc.

Experience

Jan 2016 - Jan 2017
University of Toronto
Research Associate
Biochemistry
Mar 2009 - Mar 2015
National Institutes of Health
Postdoctoral Visiting Fellow
HIV and AIDS Malignancy Branch, NCI
May 2015 - Jan 2015
GSL Medical College and General Hospital
Assistant Professor
Pharmacology
Jul 2004 - Apr 2009
Wayne State University School of Medicine
Research Assistant
Biochemistry and Molecular Biology
Jan 2018
Institute for Stem Cell Biology and Regenerative Medicine
Team Lead
Structural Biology, Centre for Chemical Biology and Therapeutics

Publications

19Publications

388Reads

1Profile Views

127PubMed Central Citations

A Novel Polar Core and Weakly Fixed C-Tail in Squid Arrestin Provide New Insight into Interaction with Rhodopsin.

J Mol Biol 2018 10 16;430(21):4102-4118. Epub 2018 Aug 16.

Department of Biochemistry, University of Toronto, Toronto, Ontario M5S 1A8, Canada; Department of Molecular Genetics, University of Toronto, Toronto, Ontario M5S 1A8, Canada. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00222836183038
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http://dx.doi.org/10.1016/j.jmb.2018.08.009DOI Listing
October 2018
12 Reads
4.333 Impact Factor

Proteasome dynamics between proliferation and quiescence stages of Saccharomyces cerevisiae.

Crit Rev Biochem Mol Biol 2016 Nov/Dec;51(6):497-512. Epub 2016 Sep 28.

a Department of Biochemistry , University of Toronto , Toronto , Canada.

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http://dx.doi.org/10.1080/10409238.2016.1230087DOI Listing
June 2017
36 Reads
4 Citations
7.714 Impact Factor

AAA-ATPases in Protein Degradation.

Front Mol Biosci 2017 20;4:42. Epub 2017 Jun 20.

Department of Biochemistry, University of TorontoToronto, ON, Canada.

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http://dx.doi.org/10.3389/fmolb.2017.00042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5476697PMC
June 2017
40 Reads

C-5-Modified Tetrahydropyrano-Tetrahydofuran-Derived Protease Inhibitors (PIs) Exert Potent Inhibition of the Replication of HIV-1 Variants Highly Resistant to Various PIs, including Darunavir.

J Virol 2015 Nov 18;90(5):2180-94. Epub 2015 Nov 18.

Experimental Retrovirology Section, HIV and AIDS Malignancy Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA Departments of Infectious Diseases and Hematology, Kumamoto University Graduate School of Medical Sciences, Kumamoto, Japan Research Institute and Center for Clinical Sciences, National Center for Global Health and Medicine, Tokyo, Japan

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http://dx.doi.org/10.1128/JVI.01829-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4810716PMC
November 2015
35 Reads
4 Citations
4.440 Impact Factor

A multi-drug resistant HIV-1 protease is resistant to the dimerization inhibitory activity of TLF-PafF.

J Mol Graph Model 2014 Sep 4;53:105-111. Epub 2014 Jul 4.

Queensborough Community College-City University of New York, Bayside, NY 11364, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jmgm.2014.06.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4287366PMC
September 2014
34 Reads
1.722 Impact Factor

A conserved hydrogen-bonding network of P2 bis-tetrahydrofuran-containing HIV-1 protease inhibitors (PIs) with a protease active-site amino acid backbone aids in their activity against PI-resistant HIV.

Antimicrob Agents Chemother 2014 Jul 21;58(7):3679-88. Epub 2014 Apr 21.

Experimental Retrovirology Section, HIV and AIDS Malignancy Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA Departments of Hematology and Infectious Diseases, Kumamoto University Graduate School of Biomedical Sciences, Kumamoto, Japan

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http://dx.doi.org/10.1128/AAC.00107-14DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4068604PMC
July 2014
37 Reads
8 Citations
4.480 Impact Factor

P1 and P1' para-fluoro phenyl groups show enhanced binding and favorable predicted pharmacological properties: structure-based virtual screening of extended lopinavir analogs against multi-drug resistant HIV-1 protease.

J Mol Graph Model 2014 Feb 1;47:18-24. Epub 2013 Nov 1.

Department of Biochemistry and Molecular Biology, School of Medicine, Wayne State University, 540 E. Canfield Avenue, Detroit, MI 48201, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jmgm.2013.10.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4520429PMC
February 2014
9 Reads
1 Citation
1.722 Impact Factor

Design, synthesis and evaluation of a potent substrate analog inhibitor identified by scanning Ala/Phe mutagenesis, mimicking substrate co-evolution, against multidrug-resistant HIV-1 protease.

Biochem Biophys Res Commun 2013 Sep 3;438(4):703-8. Epub 2013 Aug 3.

Department of Biochemistry and Molecular Biology, School of Medicine, Wayne State University, Detroit, MI 48201, USA.

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http://dx.doi.org/10.1016/j.bbrc.2013.07.117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4288442PMC
September 2013
10 Reads
2 Citations
2.300 Impact Factor

Crystallographic study of multi-drug resistant HIV-1 protease lopinavir complex: mechanism of drug recognition and resistance.

Biochem Biophys Res Commun 2013 Jul 18;437(2):199-204. Epub 2013 Jun 18.

Department of Biochemistry and Molecular Biology, Wayne State University School of Medicine, Detroit, MI 48201, United States.

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http://dx.doi.org/10.1016/j.bbrc.2013.06.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4520426PMC
July 2013
10 Reads
1 Citation
2.300 Impact Factor

Insights into the mechanism of drug resistance: X-ray structure analysis of multi-drug resistant HIV-1 protease ritonavir complex.

Biochem Biophys Res Commun 2013 Feb 8;431(2):232-8. Epub 2013 Jan 8.

Department of Biochemistry and Molecular Biology, School of Medicine, Wayne State University, Detroit, MI 48201, USA.

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http://dx.doi.org/10.1016/j.bbrc.2012.12.127DOI Listing
February 2013
6 Reads
1 Citation
2.300 Impact Factor

Conserved hydrogen bonds and water molecules in MDR HIV-1 protease substrate complexes.

Biochem Biophys Res Commun 2013 Jan 19;430(3):1022-7. Epub 2012 Dec 19.

Department of Biochemistry and Molecular Biology, Wayne State University School of Medicine Detroit, MI 48201, USA.

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http://dx.doi.org/10.1016/j.bbrc.2012.12.045DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4520401PMC
January 2013
4 Reads
5 Citations
2.300 Impact Factor

Crystal structures of multidrug-resistant HIV-1 protease in complex with two potent anti-malarial compounds.

Biochem Biophys Res Commun 2012 May 24;421(3):413-7. Epub 2012 Mar 24.

Department of Biochemistry and Molecular Biology, School of Medicine, Wayne State University, 540 E. Canfield Avenue, Detroit, MI 48201, USA.

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http://dx.doi.org/10.1016/j.bbrc.2012.03.096DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3351498PMC
May 2012
13 Reads
6 Citations
2.300 Impact Factor

Crystal structure of the extracellular domain of human myelin protein zero.

Proteins 2012 Jan 4;80(1):307-13. Epub 2011 Oct 4.

Department of Biochemistry and Molecular Biology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA.

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http://dx.doi.org/10.1002/prot.23164DOI Listing
January 2012
5 Reads
4 Citations
2.630 Impact Factor

Contribution of the 80s loop of HIV-1 protease to the multidrug-resistance mechanism: crystallographic study of MDR769 HIV-1 protease variants.

Acta Crystallogr D Biol Crystallogr 2011 Jun 17;67(Pt 6):524-32. Epub 2011 May 17.

Department of Biochemistry and Molecular Biology, School of Medicine, Wayne State University, 540 East Canfield Avenue, Detroit, MI 48201, USA.

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http://journals.iucr.org/d/issues/2011/06/00/mn5004/mn5004.p
Web Search
http://scripts.iucr.org/cgi-bin/paper?S0907444911011541
Publisher Site
http://dx.doi.org/10.1107/S0907444911011541DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3107050PMC
June 2011
4 Reads
13 Citations
7.232 Impact Factor

Novel HIV-1 protease inhibitors (PIs) containing a bicyclic P2 functional moiety, tetrahydropyrano-tetrahydrofuran, that are potent against multi-PI-resistant HIV-1 variants.

Antimicrob Agents Chemother 2011 Apr 31;55(4):1717-27. Epub 2011 Jan 31.

Department of Hematology, Kumamoto University School of Medicine, Kumamoto 860-8556, Japan.

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http://dx.doi.org/10.1128/AAC.01540-10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3067155PMC
April 2011
19 Reads
13 Citations
4.480 Impact Factor

Mechanism-based inhibitors of the aspartyl protease plasmepsin II as potential antimalarial agents.

J Med Chem 2010 May;53(10):4234-47

Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, Michigan 48202, USA.

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http://dx.doi.org/10.1021/jm100233bDOI Listing
May 2010
27 Reads
5 Citations
5.450 Impact Factor

Differential gene expression, GATA1 target genes, and the chemotherapy sensitivity of Down syndrome megakaryocytic leukemia.

Blood 2006 Feb 25;107(4):1570-81. Epub 2005 Oct 25.

Experimental and Clinical Therapeutics Program, Barbara Ann Karmanos Cancer Institute of Environmental Sciences, Wayne State University, Detroit, MI 48201, USA.

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http://dx.doi.org/10.1182/blood-2005-06-2219DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1895418PMC
February 2006
22 Reads
47 Citations
10.452 Impact Factor