Ravi Iyengar

Ravi Iyengar

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Ravi Iyengar

Publications by authors named "Ravi Iyengar"

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Evaluation of a gender-affirming healthcare curriculum for second-year medical students.

Postgrad Med J 2019 Dec 11. Epub 2019 Dec 11.

Department of Psychiatry, Road Home Program, Rush University Medical Center, Chicago, Illinois, USA.

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http://dx.doi.org/10.1136/postgradmedj-2019-136683DOI Listing
December 2019

Genomic signatures defining responsiveness to allopurinol and combination therapy for lung cancer identified by systems therapeutics analyses.

Mol Oncol 2019 08 10;13(8):1725-1743. Epub 2019 Jul 10.

Department of Pharmacological Sciences, Systems Biology Center New York, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

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http://dx.doi.org/10.1002/1878-0261.12521DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6670022PMC
August 2019

Geometric principles of second messenger dynamics in dendritic spines.

Sci Rep 2019 Aug 12;9(1):11676. Epub 2019 Aug 12.

Department of Mechanical and Aerospace Engineering, University of California San Diego, La Jolla, 92093-0411, CA, United States.

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http://dx.doi.org/10.1038/s41598-019-48028-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6691135PMC
August 2019

Wilm's tumor 1 promotes memory flexibility.

Nat Commun 2019 08 21;10(1):3756. Epub 2019 Aug 21.

Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, One Gustave Levy Place, New York, 10029, NY, USA.

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http://dx.doi.org/10.1038/s41467-019-11781-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6704057PMC
August 2019

Dynamic balance between vesicle transport and microtubule growth enables neurite outgrowth.

PLoS Comput Biol 2019 05 1;15(5):e1006877. Epub 2019 May 1.

Department of Pharmacological Sciences and Systems Biology Center New York, Icahn School of Medicine at Mount Sinai, New York, NY, United States of America.

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http://dx.doi.org/10.1371/journal.pcbi.1006877DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6546251PMC
May 2019

OSCI: standardized stem cell ontology representation and use cases for stem cell investigation.

BMC Bioinformatics 2019 Apr 25;20(Suppl 5):180. Epub 2019 Apr 25.

Department of Biomedical Informatics, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY, USA.

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http://dx.doi.org/10.1186/s12859-019-2723-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6509805PMC
April 2019

Systems Pharmacology: Defining the Interactions of Drug Combinations.

Annu Rev Pharmacol Toxicol 2019 01 27;59:21-40. Epub 2018 Sep 27.

Department of Pharmacological Sciences, Systems Biology Center, Mount Sinai Institute for Systems Biomedicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; email:

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http://dx.doi.org/10.1146/annurev-pharmtox-010818-021511DOI Listing
January 2019

Spectrum of immune checkpoint inhibitors-induced endocrinopathies in cancer patients: a scoping review of case reports.

Clin Diabetes Endocrinol 2019 22;5. Epub 2019 Jan 22.

1Division of Metabolism, Endocrinology & Diabetes, Department of Internal Medicine, University of Michigan, 24 Frank Lloyd Wright Drive, Ann Arbor, MI 48106 USA.

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https://clindiabetesendo.biomedcentral.com/articles/10.1186/
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http://dx.doi.org/10.1186/s40842-018-0073-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343255PMC
January 2019

Systems biology primer: the basic methods and approaches.

Essays Biochem 2018 10 26;62(4):487-500. Epub 2018 Oct 26.

Department of Pharmacological Sciences and Systems Biology Center New York, Icahn School of Medicine at Mount Sinai, New York, NY 10029, U.S.A.

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http://dx.doi.org/10.1042/EBC20180003DOI Listing
October 2018

Inpatient Glycemic Management in the Setting of Renal Insufficiency/Failure/Dialysis.

Curr Diab Rep 2018 08 15;18(10):75. Epub 2018 Aug 15.

Department of Metabolism, Endocrinology, and Diabetes, Department of Internal Medicine, University of Michigan, Domino's Farms (Lobby G, Suite 1500) 24 Frank Lloyd Wright Drive, Ann Arbor, MI, 48106, USA.

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http://dx.doi.org/10.1007/s11892-018-1044-yDOI Listing
August 2018

Validating Antibodies for Quantitative Western Blot Measurements with Microwestern Array.

Sci Rep 2018 07 27;8(1):11329. Epub 2018 Jul 27.

Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.

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http://dx.doi.org/10.1038/s41598-018-29436-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6063895PMC
July 2018

Cell Type-Specific Contributions of the Angiotensin II Type 1a Receptor to Aorta Homeostasis and Aneurysmal Disease-Brief Report.

Arterioscler Thromb Vasc Biol 2018 03 25;38(3):588-591. Epub 2018 Jan 25.

From the Department of Pharmacological Sciences and Institute for Systems Biomedicine, Icahn School of Medicine at Mount Sinai, New York.

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http://dx.doi.org/10.1161/ATVBAHA.117.310609DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5823778PMC
March 2018

The Library of Integrated Network-Based Cellular Signatures NIH Program: System-Level Cataloging of Human Cells Response to Perturbations.

Authors:
Alexandra B Keenan Sherry L Jenkins Kathleen M Jagodnik Simon Koplev Edward He Denis Torre Zichen Wang Anders B Dohlman Moshe C Silverstein Alexander Lachmann Maxim V Kuleshov Avi Ma'ayan Vasileios Stathias Raymond Terryn Daniel Cooper Michele Forlin Amar Koleti Dusica Vidovic Caty Chung Stephan C Schürer Jouzas Vasiliauskas Marcin Pilarczyk Behrouz Shamsaei Mehdi Fazel Yan Ren Wen Niu Nicholas A Clark Shana White Naim Mahi Lixia Zhang Michal Kouril John F Reichard Siva Sivaganesan Mario Medvedovic Jaroslaw Meller Rick J Koch Marc R Birtwistle Ravi Iyengar Eric A Sobie Evren U Azeloglu Julia Kaye Jeannette Osterloh Kelly Haston Jaslin Kalra Steve Finkbiener Jonathan Li Pamela Milani Miriam Adam Renan Escalante-Chong Karen Sachs Alex Lenail Divya Ramamoorthy Ernest Fraenkel Gavin Daigle Uzma Hussain Alyssa Coye Jeffrey Rothstein Dhruv Sareen Loren Ornelas Maria Banuelos Berhan Mandefro Ritchie Ho Clive N Svendsen Ryan G Lim Jennifer Stocksdale Malcolm S Casale Terri G Thompson Jie Wu Leslie M Thompson Victoria Dardov Vidya Venkatraman Andrea Matlock Jennifer E Van Eyk Jacob D Jaffe Malvina Papanastasiou Aravind Subramanian Todd R Golub Sean D Erickson Mohammad Fallahi-Sichani Marc Hafner Nathanael S Gray Jia-Ren Lin Caitlin E Mills Jeremy L Muhlich Mario Niepel Caroline E Shamu Elizabeth H Williams David Wrobel Peter K Sorger Laura M Heiser Joe W Gray James E Korkola Gordon B Mills Mark LaBarge Heidi S Feiler Mark A Dane Elmar Bucher Michel Nederlof Damir Sudar Sean Gross David F Kilburn Rebecca Smith Kaylyn Devlin Ron Margolis Leslie Derr Albert Lee Ajay Pillai

Cell Syst 2018 01 29;6(1):13-24. Epub 2017 Nov 29.

NIH, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1016/j.cels.2017.11.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5799026PMC
January 2018

Cell shape information is transduced through tension-independent mechanisms.

Nat Commun 2017 12 15;8(1):2145. Epub 2017 Dec 15.

Department of Pharmacological Sciences and Systems Biology Center New York, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.

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http://dx.doi.org/10.1038/s41467-017-02218-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5732205PMC
December 2017

A flexible ontology for inference of emergent whole cell function from relationships between subcellular processes.

Sci Rep 2017 12 18;7(1):17689. Epub 2017 Dec 18.

Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.

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http://dx.doi.org/10.1038/s41598-017-16627-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5735158PMC
December 2017

Fragility of foot process morphology in kidney podocytes arises from chaotic spatial propagation of cytoskeletal instability.

PLoS Comput Biol 2017 03 16;13(3):e1005433. Epub 2017 Mar 16.

R. D. Berlin Center for Cell Analysis & Modeling, U. Connecticut School of Medicine, Farmington, CT, United States of America.

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http://dx.doi.org/10.1371/journal.pcbi.1005433DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5373631PMC
March 2017

MEDICINE. Personalization in practice.

Science 2015 Oct;350(6258):282-3

Department of Systems Pharmacology and Translational Therapeutics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

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http://dx.doi.org/10.1126/science.aad5204DOI Listing
October 2015

Multiscale modeling of cell shape from the actin cytoskeleton.

Prog Mol Biol Transl Sci 2014 ;123:143-67

Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, USA; Systems Biology Center New York, Mount Sinai School of Medicine, New York, USA.

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http://dx.doi.org/10.1016/B978-0-12-397897-4.00002-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4966540PMC
April 2015

Signaling networks: information flow, computation, and decision making.

Cold Spring Harb Perspect Biol 2015 Apr 1;7(4):a005934. Epub 2015 Apr 1.

Department of Pharmacology and Systems Therapeutics and Systems Biology Center New York, Mount Sinai School of Medicine, New York, New York 10029.

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http://dx.doi.org/10.1101/cshperspect.a005934DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4382748PMC
April 2015

Good practices for building dynamical models in systems biology.

Sci Signal 2015 Apr 7;8(371):fs8. Epub 2015 Apr 7.

Department of Pharmacology and Systems Therapeutics, Systems Biology Center New York, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

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http://dx.doi.org/10.1126/scisignal.aab0880DOI Listing
April 2015

Can intracellular cAMP dynamics enable scalable computation?

Authors:
Ravi Iyengar

Front Cell Neurosci 2015 27;9:112. Epub 2015 Mar 27.

Department of Pharmacology and Systems Therapeutics, Systems Biology Center, Icahn School of Medicine at Mount Sinai New York, NY, USA.

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http://dx.doi.org/10.3389/fncel.2015.00112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4375975PMC
April 2015

Small molecule-mediated directed differentiation of human embryonic stem cells toward ventricular cardiomyocytes.

Stem Cells Transl Med 2014 Jan 9;3(1):18-31. Epub 2013 Dec 9.

Cardiovascular Research Center and Department of Pharmacology and Systems Therapeutics, Systems Biology Center, Icahn School of Medicine at Mount Sinai, New York, New York, USA; Stem Cell and Regenerative Medicine Consortium, Department of Physiology, LKS Faculty of Medicine, University of Hong Kong, Hong Kong.

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http://doi.wiley.com/10.5966/sctm.2013-0110
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http://dx.doi.org/10.5966/sctm.2013-0110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3902291PMC
January 2014

Complex diseases require complex therapies.

Authors:
Ravi Iyengar

EMBO Rep 2013 Dec 15;14(12):1039-42. Epub 2013 Nov 15.

Department of Pharmacology and Systems Therapeutics, Systems Biology Centre New York, Icahn School of Medicine in New York, New York, USA.

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http://dx.doi.org/10.1038/embor.2013.177DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3981088PMC
December 2013

Systems pharmacology of adverse event mitigation by drug combinations.

Sci Transl Med 2013 Oct;5(206):206ra140

Department of Pharmacology and Systems Therapeutics, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

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http://dx.doi.org/10.1126/scitranslmed.3006548DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3963511PMC
October 2013

Decoding information in cell shape.

Cell 2013 Sep;154(6):1356-69

Department of Pharmacology and Systems Therapeutics and Systems Biology Center, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

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http://dx.doi.org/10.1016/j.cell.2013.08.026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3874130PMC
September 2013

A potential peptide therapeutic derived from the juxtamembrane domain of the epidermal growth factor receptor.

PLoS One 2012 15;7(11):e49702. Epub 2012 Nov 15.

Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, New York, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0049702PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3499488PMC
June 2013

Systems pharmacology: network analysis to identify multiscale mechanisms of drug action.

Annu Rev Pharmacol Toxicol 2012 ;52:505-21

Department of Pharmacology and Systems Therapeutics, and Systems Biology Center New York, Mount Sinai School of Medicine, New York, New York 10029, USA.

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http://dx.doi.org/10.1146/annurev-pharmtox-010611-134520DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3619403PMC
May 2012

Merging systems biology with pharmacodynamics.

Sci Transl Med 2012 Mar;4(126):126ps7

Department of Pharmacology and Systems Therapeutics, Systems Biology Center New York, Mount Sinai School of Medicine, New York, NY 10029, USA.

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http://dx.doi.org/10.1126/scitranslmed.3003563DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3405973PMC
March 2012

Systems biology of kidney diseases.

Kidney Int 2012 Jan 31;81(1):22-39. Epub 2011 Aug 31.

Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA.

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http://dx.doi.org/10.1038/ki.2011.314DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3240740PMC
January 2012

Recovering protein-protein and domain-domain interactions from aggregation of IP-MS proteomics of coregulator complexes.

PLoS Comput Biol 2011 Dec 29;7(12):e1002319. Epub 2011 Dec 29.

Department of Pharmacology and Systems Therapeutics, Systems Biology Center New York (SBCNY), Mount Sinai School of Medicine, New York, New York, United States of America.

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http://dx.doi.org/10.1371/journal.pcbi.1002319DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3248428PMC
December 2011

Systems pharmacology of complex diseases.

Ann N Y Acad Sci 2011 Dec;1245:E1-5

Pharmacology and Systems Therapeutics and Systems Biology Center, Mount Sinai School of Medicine, New York, New York 10029, USA.

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http://dx.doi.org/10.1111/j.1749-6632.2011.06382.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3620720PMC
December 2011

Identification of new Gβγ interaction sites in adenylyl cyclase 2.

Cell Signal 2011 Sep 8;23(9):1489-95. Epub 2011 May 8.

Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, NY 10029, USA.

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http://dx.doi.org/10.1016/j.cellsig.2011.05.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3115457PMC
September 2011

Systems biology--biomedical modeling.

Sci Signal 2011 Sep 6;4(190):tr2. Epub 2011 Sep 6.

Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY 10029, USA.

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http://dx.doi.org/10.1126/scisignal.2001989DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3188945PMC
September 2011

Drug discovery in academic settings.

Authors:
Ravi Iyengar

Mt Sinai J Med 2010 Jul-Aug;77(4):325-6

Department of Pharmacology and Systems Therapeutics, Experimental Therapeutics Institute, Mount Sinai School of Medicine, New York, NY, USA.

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http://dx.doi.org/10.1002/msj.20190DOI Listing
June 2011

Systems pharmacology.

Mt Sinai J Med 2010 Jul-Aug;77(4):333-44

Mount Sinai School of Medicine, New York, NY, USA.

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http://dx.doi.org/10.1002/msj.20191DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3113679PMC
June 2011

Role of systems pharmacology in understanding drug adverse events.

Wiley Interdiscip Rev Syst Biol Med 2011 Mar-Apr;3(2):129-35. Epub 2010 Aug 27.

Department of Pharmacology and Systems Biology Center New York, Mount Sinai School of Medicine, New York, NY, USA.

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http://dx.doi.org/10.1002/wsbm.114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3057924PMC
June 2011

Selective release of microRNA species from normal and malignant mammary epithelial cells.

PLoS One 2010 Oct 20;5(10):e13515. Epub 2010 Oct 20.

Department of Pathology, The Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago, Illinois, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0013515PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2958125PMC
October 2010

Systems approaches to polypharmacology and drug discovery.

Curr Opin Drug Discov Devel 2010 May;13(3):297-309

Mount Sinai School of Medicine, Department of Pharmacology and Systems Therapeutics, One Gustave L Levy Place, New York, NY 10029, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3068535PMC
May 2010

Mechanisms controlling cell size and shape during isotropic cell spreading.

Biophys J 2010 May;98(10):2136-46

Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, New York, USA.

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http://dx.doi.org/10.1016/j.bpj.2010.01.059DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2872297PMC
May 2010

Systems pharmacology of arrhythmias.

Sci Signal 2010 Apr 20;3(118):ra30. Epub 2010 Apr 20.

Department of Pharmacology and Systems Therapeutics and Systems Biology Center New York, Mount Sinai School of Medicine, One Gustave L. Levy Place, Box 1215, New York, NY 10029, USA.

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http://stke.sciencemag.org/cgi/doi/10.1126/scisignal.2000723
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http://dx.doi.org/10.1126/scisignal.2000723DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3068558PMC
April 2010

Cannabinoid 1 receptor and interleukin-6 receptor together induce integration of protein kinase and transcription factor signaling to trigger neurite outgrowth.

J Biol Chem 2010 Jan 27;285(2):1358-70. Epub 2009 Oct 27.

Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, New York 10029, USA.

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http://dx.doi.org/10.1074/jbc.M109.049841DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2801262PMC
January 2010

Design of versatile biochemical switches that respond to amplitude, duration, and spatial cues.

Proc Natl Acad Sci U S A 2010 Jan 28;107(3):1247-52. Epub 2009 Dec 28.

Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY 10029, USA.

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http://dx.doi.org/10.1073/pnas.0908647107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2824311PMC
January 2010

Reduction of Stat3 activity attenuates HIV-induced kidney injury.

J Am Soc Nephrol 2009 Oct 16;20(10):2138-46. Epub 2009 Jul 16.

Department of Nephrology, RuiJin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

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http://dx.doi.org/10.1681/ASN.2008080879DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2754106PMC
October 2009

Network analyses in systems pharmacology.

Bioinformatics 2009 Oct 30;25(19):2466-72. Epub 2009 Jul 30.

Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, One Gustave Levy Place, New York, NY 10029, USA.

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https://academic.oup.com/bioinformatics/article-lookup/doi/1
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http://dx.doi.org/10.1093/bioinformatics/btp465DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2752618PMC
October 2009

Systems approach to explore components and interactions in the presynapse.

Proteomics 2009 Jun;9(12):3303-15

Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY 10029, USA.

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http://dx.doi.org/10.1002/pmic.200800767DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2766278PMC
June 2009

Why we need quantitative dynamic models.

Authors:
Ravi Iyengar

Sci Signal 2009 Mar 31;2(64):eg3. Epub 2009 Mar 31.

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http://dx.doi.org/10.1126/scisignal.264eg3DOI Listing
March 2009

Specification of spatial relationships in directed graphs of cell signaling networks.

Ann N Y Acad Sci 2009 Mar;1158:44-56

Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, New York, USA.

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http://dx.doi.org/10.1111/j.1749-6632.2008.03748.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2728682PMC
March 2009

Computational biochemistry: systems biology minireview series.

Authors:
Ravi Iyengar

J Biol Chem 2009 Feb 20;284(9):5425-6. Epub 2008 Oct 20.

Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, New York 10029, USA.

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http://dx.doi.org/10.1074/jbc.R800066200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3837388PMC
February 2009

Models of spatially restricted biochemical reaction systems.

J Biol Chem 2009 Feb 20;284(9):5445-9. Epub 2008 Oct 20.

Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, New York 10029, USA.

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http://dx.doi.org/10.1074/jbc.R800058200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2645809PMC
February 2009

SNAVI: Desktop application for analysis and visualization of large-scale signaling networks.

BMC Syst Biol 2009 Jan 20;3:10. Epub 2009 Jan 20.

Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY 10029, USA.

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http://dx.doi.org/10.1186/1752-0509-3-10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2637233PMC
January 2009

Neuro2A differentiation by Galphai/o pathway.

Sci Signal 2009 Jan 20;2(54):cm1. Epub 2009 Jan 20.

Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY 10029, USA.

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http://dx.doi.org/10.1126/scisignal.254cm1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2649824PMC
January 2009

Systems pharmacology and genome medicine: a future perspective.

Genome Med 2009 Jan 22;1(1):11. Epub 2009 Jan 22.

Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, One Gustave Levy Place, New York, NY 10029, USA.

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http://genomemedicine.biomedcentral.com/articles/10.1186/gm1
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http://dx.doi.org/10.1186/gm11DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2651594PMC
January 2009

Modelling cellular signalling systems.

Essays Biochem 2008 ;45:83-94

Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY 10029, U.S.A.

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http://dx.doi.org/10.1042/BSE0450083DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3270941PMC
December 2008

Ordered cyclic motifs contribute to dynamic stability in biological and engineered networks.

Proc Natl Acad Sci U S A 2008 Dec 25;105(49):19235-40. Epub 2008 Nov 25.

Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, 1 Gustave Levy Place, New York, NY 10029, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.0805344105
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http://dx.doi.org/10.1073/pnas.0805344105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2614745PMC
December 2008

Galphao/i-stimulated proteosomal degradation of RGS20: a mechanism for temporal integration of Gs and Gi pathways.

Cell Signal 2008 Jun 19;20(6):1190-7. Epub 2008 Feb 19.

Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, New York, NY 10029, United States.

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http://dx.doi.org/10.1016/j.cellsig.2008.02.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3107604PMC
June 2008

Design logic of a cannabinoid receptor signaling network that triggers neurite outgrowth.

Science 2008 May;320(5878):903-9

Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY 10029, USA.

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http://dx.doi.org/10.1126/science.1152662DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2776723PMC
May 2008

Regulation of neurite outgrowth by G(i/o) signaling pathways.

Front Biosci 2008 May 1;13:4544-57. Epub 2008 May 1.

Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY 10029, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3068557PMC
http://dx.doi.org/10.2741/3022DOI Listing
May 2008

Functions of bifans in context of multiple regulatory motifs in signaling networks.

Biophys J 2008 Apr 4;94(7):2566-79. Epub 2008 Jan 4.

Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, New York 10029, USA.

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http://dx.doi.org/10.1529/biophysj.107.116673DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2267139PMC
April 2008

Teaching resource. Quantitative models of mammalian cell signaling pathways.

Authors:
Ravi Iyengar

Sci Signal 2008 ;1(7):tr1

Department of Pharmacology and SystemsTherapeutics, Mount Sinai School ofMedicine, New York, NY 10029, USA.

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http://dx.doi.org/10.1126/stke.17tr1DOI Listing
April 2008

Teaching resources. Using web-based discussion forums as a model of the peer-review process and a tool for assessment.

Sci Signal 2008 ;1(9):tr2

Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY 10029, USA.

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http://dx.doi.org/10.1126/stke.19tr2DOI Listing
April 2008

HIV-1 Nef disrupts the podocyte actin cytoskeleton by interacting with diaphanous interacting protein.

J Biol Chem 2008 Mar 30;283(13):8173-82. Epub 2008 Jan 30.

Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA.

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http://dx.doi.org/10.1074/jbc.M708920200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2276381PMC
March 2008

Inquiry learning. Integrating content detail and critical reasoning by peer review.

Science 2008 Feb;319(5867):1189-90

Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, NY 10029, USA.

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http://dx.doi.org/10.1126/science.1149875DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3038128PMC
February 2008

AVIS: AJAX viewer of interactive signaling networks.

Bioinformatics 2007 Oct 12;23(20):2803-5. Epub 2007 Sep 12.

Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, 1425 Madison Avenue, New York 10029, USA.

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https://academic.oup.com/bioinformatics/article-lookup/doi/1
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http://dx.doi.org/10.1093/bioinformatics/btm444DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2724864PMC
October 2007

Functional atlas of the integrin adhesome.

Nat Cell Biol 2007 Aug;9(8):858-67

Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, 76100, Israel.

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http://www.nature.com/articles/ncb0807-858
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http://dx.doi.org/10.1038/ncb0807-858DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2735470PMC
August 2007

An androgen-IL-6-Stat3 autocrine loop re-routes EGF signal in prostate cancer cells.

Mol Cell Endocrinol 2007 May 17;270(1-2):50-6. Epub 2007 Feb 17.

Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, New York, NY, USA.

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http://dx.doi.org/10.1016/j.mce.2007.02.006DOI Listing
May 2007

Network analysis of FDA approved drugs and their targets.

Mt Sinai J Med 2007 Apr;74(1):27-32

Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine, New York, New York 10029, USA.

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http://dx.doi.org/10.1002/msj.20002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2561141PMC
April 2007

Compartment-specific feedback loop and regulated trafficking can result in sustained activation of Ras at the Golgi.

Biophys J 2007 Feb 10;92(3):808-15. Epub 2006 Nov 10.

Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, New York, New York 10029, USA.

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http://dx.doi.org/10.1529/biophysj.106.093104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1779960PMC
February 2007

Retinoic acid inhibits HIV-1-induced podocyte proliferation through the cAMP pathway.

J Am Soc Nephrol 2007 Jan 20;18(1):93-102. Epub 2006 Dec 20.

Department of Medicine, Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, NY 10029, USA.

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http://dx.doi.org/10.1681/ASN.2006070727DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3197239PMC
January 2007

Modelling spatio-temporal interactions within the cell.

J Biosci 2007 Jan;32(1):157-67

Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029, USA.

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http://dx.doi.org/10.1007/s12038-007-0014-3DOI Listing
January 2007

The cognitive phenotype of Down syndrome: insights from intracellular network analysis.

NeuroRx 2006 Jul;3(3):396-406

Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, New York, New York 10029, USA.

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http://dx.doi.org/10.1016/j.nurx.2006.05.036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3032589PMC
July 2006

Role of the Go/i signaling network in the regulation of neurite outgrowth.

Can J Physiol Pharmacol 2006 Jul;84(7):687-94

Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, One Gustave L levy Place, New York, NY 10029, USA.

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http://dx.doi.org/10.1139/y06-025DOI Listing
July 2006

Topology of resultant networks shaped by evolutionary pressure.

Phys Rev E Stat Nonlin Soft Matter Phys 2006 Jun 19;73(6 Pt 1):061912. Epub 2006 Jun 19.

Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, New York, New York 10029, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3032447PMC
http://dx.doi.org/10.1103/PhysRevE.73.061912DOI Listing
June 2006

From components to regulatory motifs in signalling networks.

Brief Funct Genomic Proteomic 2006 Mar 20;5(1):57-61. Epub 2006 Feb 20.

Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, 1 Gustave Levy Place, New York, NY 10029, USA.

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http://dx.doi.org/10.1093/bfgp/ell004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3035204PMC
March 2006

The G alpha(o/i)-coupled cannabinoid receptor-mediated neurite outgrowth involves Rap regulation of Src and Stat3.

J Biol Chem 2005 Sep 26;280(39):33426-34. Epub 2005 Jul 26.

Department of Pharmacology, Mount Sinai School of Medicine, New York, New York 10029, USA.

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http://dx.doi.org/10.1074/jbc.M502812200DOI Listing
September 2005

Toward predictive models of mammalian cells.

Annu Rev Biophys Biomol Struct 2005 ;34:319-49

Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, New York, NY 10029, USA.

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http://www.annualreviews.org/doi/10.1146/annurev.biophys.34.
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http://dx.doi.org/10.1146/annurev.biophys.34.040204.144415DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3035045PMC
July 2005

Cannabinoid receptor-induced neurite outgrowth is mediated by Rap1 activation through G(alpha)o/i-triggered proteasomal degradation of Rap1GAPII.

J Biol Chem 2005 Mar 18;280(12):11413-21. Epub 2005 Jan 18.

Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, New York, New York 10029, USA.

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http://dx.doi.org/10.1074/jbc.M411521200DOI Listing
March 2005

Teaching resources. Structure of G-protein-coupled receptors and G proteins.

Authors:
Ravi Iyengar

Sci STKE 2005 Mar 22;2005(276):tr10. Epub 2005 Mar 22.

Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, New York, NY 10029, USA.

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http://dx.doi.org/10.1126/stke.2762005tr10DOI Listing
March 2005

Teaching resources. Cell signaling systems: a course for graduate students.

Sci STKE 2005 Feb 1;2005(269):tr3. Epub 2005 Feb 1.

Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, New York, NY 10029, USA.

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http://dx.doi.org/10.1126/stke.2692005tr3DOI Listing
February 2005

Teaching resources. Introduction: Overview of pathways and networks and GPCR signaling.

Authors:
Ravi Iyengar

Sci STKE 2005 Feb 8;2005(270):tr4. Epub 2005 Feb 8.

Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, New York, NY 10029, USA.

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http://dx.doi.org/10.1126/stke.2702005tr4DOI Listing
February 2005

Postsynaptic signaling networks: cellular cogwheels underlying long-term plasticity.

Biol Psychiatry 2005 Jan;57(2):113-9

Department of Psychiatry, Mount Sinai School of Medicine, New York, New York 10029, USA.

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http://dx.doi.org/10.1016/j.biopsych.2004.02.031DOI Listing
January 2005

Computational approaches for modeling regulatory cellular networks.

Trends Cell Biol 2004 Dec;14(12):661-9

Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, New York, NY 10029, USA.

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http://dx.doi.org/10.1016/j.tcb.2004.10.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3619405PMC
December 2004

Quantitative information management for the biochemical computation of cellular networks.

Sci STKE 2004 Aug 24;2004(248):pl11. Epub 2004 Aug 24.

Department of Physiology and Biophysics and Institute for Computational Biomedicine, Weill Medical College of Cornell University, New York, NY, 10021, USA.

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http://dx.doi.org/10.1126/stke.2482004pl11DOI Listing
August 2004

Modeling cell signaling networks.

Biol Cell 2004 Jun;96(5):355-62

Department of Pharmacology and Biological Chemistry, Mount Sinai School of Medicine, New York, NY 10029, USA.

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http://dx.doi.org/10.1016/j.biolcel.2004.03.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3620715PMC
June 2004