Raul Urrutia

Raul Urrutia

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Raul Urrutia

Raul Urrutia

Publications by authors named "Raul Urrutia"

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100Publications

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Combined Targeting of G9a and Checkpoint kinase 1 Synergistically Inhibits Pancreatic Cancer Cell Growth by Replication Fork Collapse.

Authors:
Guillermo Urrutia Ann Salmonson Jorge A Toro-Zapata Thiago M de Assuncao Angela Mathison Nelson Dusetti Juan Iovanna Raul Urrutia Gwen Lomberk

Mol Cancer Res 2019 Dec 10. Epub 2019 Dec 10.

Surgery, Medical College of Wisconsin

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http://dx.doi.org/10.1158/1541-7786.MCR-19-0490DOI Listing
December 2019

Modeling post-translational modifications and cancer-associated mutations that impact the heterochromatin protein 1α-importin α heterodimers.

Authors:
Michael T Zimmermann Monique M Williams Eric W Klee Gwen A Lomberk Raul Urrutia

Proteins 2019 Nov 14;87(11):904-916. Epub 2019 Jun 14.

Division of Research, Department of Surgery, Medical College of Wisconsin, Milwaukee, Wisconsin.

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http://dx.doi.org/10.1002/prot.25752DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6790107PMC
November 2019

SOD2 acetylation on lysine 68 promotes stem cell reprogramming in breast cancer.

Authors:
Chenxia He Jeanne M Danes Peter C Hart Yueming Zhu Yunping Huang Andre Luelsdorf de Abreu Joseph O'Brien Angela J Mathison Binwu Tang Jonna M Frasor Lalage M Wakefield Douglas Ganini Erich Stauder Jacek Zielonka Benjamin N Gantner Raul A Urrutia David Gius Marcelo G Bonini

Proc Natl Acad Sci U S A 2019 Nov 7;116(47):23534-23541. Epub 2019 Oct 7.

Department of Medicine, Division of Endocrinology, Medical College of Wisconsin, Milwaukee, WI 53226;

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http://dx.doi.org/10.1073/pnas.1902308116DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6876149PMC
November 2019

Targeting the Stress-Induced Protein NUPR1 to Treat Pancreatic Adenocarcinoma.

Authors:
Patricia Santofimia-Castaño Yi Xia Ling Peng Adrián Velázquez-Campoy Olga Abián Wenjun Lan Gwen Lomberk Raul Urrutia Bruno Rizzuti Philippe Soubeyran José Luis Neira Juan Iovanna

Cells 2019 Nov 17;8(11). Epub 2019 Nov 17.

Centre de Recherche en Cancérologie de Marseille (CRCM), INSERM U1068, CNRS UMR 7258, Aix-Marseille Université, CEDEX, Marseille 13288, France.

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http://dx.doi.org/10.3390/cells8111453DOI Listing
November 2019

Genetic variants in DGAT1 cause diverse clinical presentations of malnutrition through a specific molecular mechanism.

Authors:
Aditi Gupta Nikita R Dsouza Yuri A Zarate Rachel Lombardo Robert Hopkin Allison R Linehan Jamela Simpson Julie McCarrier Katherine E Agre Ralitza H Gavrilova Michael C Stephens Rayna M Grothe Kristin G Monaghan Yili Xie Donald Basel Raul A Urrutia Conrad R Cole Eric W Klee Michael T Zimmermann

Eur J Med Genet 2019 Nov 25:103817. Epub 2019 Nov 25.

Bioinformatics Research and Development Laboratory, Genomic Sciences and Precision Medicine Center, Medical College of Wisconsin, Milwaukee, WI, 53226, USA; Clinical and Translational Sciences Institute, Medical College of Wisconsin, Milwaukee, WI, 53226, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ejmg.2019.103817DOI Listing
November 2019

Molecular characterization of known and novel ACVR1 variants in phenotypes of aberrant ossification.

Authors:
Aditi Gupta Michael T Zimmermann Haitao Wang Stephen M Broski Ashley N Sigafoos Sarah K Macklin Raul A Urrutia Karl J Clark Paldeep S Atwal Robert J Pignolo Eric W Klee

Am J Med Genet A 2019 Sep 26;179(9):1764-1777. Epub 2019 Jun 26.

Center for Individualized Medicine, Mayo Clinic, Rochester, Minnesota.

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http://dx.doi.org/10.1002/ajmg.a.61274DOI Listing
September 2019

ErbB3-binding protein 1 (EBP1) represses HNF4α-mediated transcription and insulin secretion in pancreatic β-cells.

Authors:
Eun Hee Han Puja Singh In-Kyu Lee Raul Urrutia Young-In Chi

J Biol Chem 2019 Sep 30;294(38):13983-13994. Epub 2019 Jul 30.

Section of Structural Biology, Hormel Institute, University of Minnesota, Austin, Minnesota 55912

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http://dx.doi.org/10.1074/jbc.RA119.009558DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6755798PMC
September 2019

Precision Medicine and Precision Public Health: Academic Education and Community Engagement.

Authors:
John R Meurer Jeffrey C Whittle Kelsey M Lamb Matthew A Kosasih Melinda R Dwinell Raul A Urrutia

Am J Prev Med 2019 Aug;57(2):286-289

Department of Surgery, Medical College of Wisconsin, Milwaukee, Wisconsin; Genomic Science and Precision Medicine Center, Medical College of Wisconsin, Milwaukee, Wisconsin.

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http://dx.doi.org/10.1016/j.amepre.2019.03.010DOI Listing
August 2019

Emerging epigenomic landscapes of pancreatic cancer in the era of precision medicine.

Authors:
Gwen Lomberk Nelson Dusetti Juan Iovanna Raul Urrutia

Nat Commun 2019 08 28;10(1):3875. Epub 2019 Aug 28.

Division of Research, Department of Surgery and the Genomic Sciences and Precision Medicine Center (GSPMC), Medical College of Wisconsin, Milwaukee, WI, USA.

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http://dx.doi.org/10.1038/s41467-019-11812-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6713756PMC
August 2019

Aurora kinase B-phosphorylated HP1α functions in chromosomal instability.

Authors:
Monique M Williams Angela J Mathison Trent Christensen Patricia T Greipp Darlene L Knutson Eric W Klee Michael T Zimmermann Juan Iovanna Gwen A Lomberk Raul A Urrutia

Cell Cycle 2019 Jun 26;18(12):1407-1421. Epub 2019 May 26.

b Genomics and Precision Medicine Center (GSPMC), Medical College of Wisconsin , Milwaukee , WI , USA.

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http://dx.doi.org/10.1080/15384101.2019.1618126DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6592258PMC
June 2019

CBX5/G9a/H3K9me-mediated gene repression is essential to fibroblast activation during lung fibrosis.

Authors:
Giovanni Ligresti Nunzia Caporarello Jeffrey A Meridew Dakota L Jones Qi Tan Kyoung Moo Choi Andrew J Haak Aja Aravamudhan Anja C Roden Y S Prakash Gwen Lomberk Raul A Urrutia Daniel J Tschumperlin

JCI Insight 2019 May 16;5. Epub 2019 May 16.

Department of Physiology and Biomedical Engineering.

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http://dx.doi.org/10.1172/jci.insight.127111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6629126PMC
May 2019

Disruption of FOXP3-EZH2 Interaction Represents a Pathobiological Mechanism in Intestinal Inflammation.

Authors:
Adebowale O Bamidele Phyllis A Svingen Mary R Sagstetter Olga F Sarmento Michelle Gonzalez Manuel B Braga Neto Subra Kugathasan Gwen Lomberk Raul A Urrutia William A Faubion

Cell Mol Gastroenterol Hepatol 2019 14;7(1):55-71. Epub 2018 Sep 14.

Epigenetics and Chromatin Dynamics Laboratory, Division of Gastroenterology and Hepatology and Translational Epigenomic Program, Center for Individualized Medicine, Mayo Clinic, Rochester, Minnesota. Electronic address:

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http://dx.doi.org/10.1016/j.jcmgh.2018.08.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6260395PMC
April 2019

Enhancer of Zeste Homologue 2 Inhibition Attenuates TGF-β Dependent Hepatic Stellate Cell Activation and Liver Fibrosis.

Authors:
Rosa Martin-Mateos Thiago M De Assuncao Juan Pablo Arab Nidhi Jalan-Sakrikar Usman Yaqoob Thomas Greuter Vikas K Verma Angela J Mathison Sheng Cao Gwen Lomberk Philippe Mathurin Raul Urrutia Robert C Huebert Vijay H Shah

Cell Mol Gastroenterol Hepatol 2019 15;7(1):197-209. Epub 2018 Sep 15.

Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota. Electronic address:

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http://dx.doi.org/10.1016/j.jcmgh.2018.09.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6282644PMC
April 2019

Epigenetics of gastrointestinal diseases: notes from a workshop.

Authors:
David L Marks Rachel L Olson Raul Urrutia Daniel D Billadeau Nilotpal Roy George A Calin Muller Fabbri Marina Koutsioumpa Dimitrios Iliopoulos Tamas Ordog Robert Huebert Olga Sarmento Adebowale O Bamidele William Faubion Gwen L Lomberk Jens Siveke Nita Ahuja Juan Iovanna Ryan A Hlady Keith Robertson John Kisiel Christopher L Pin Martin E Fernandez-Zapico

Epigenetics 2018 30;13(4):449-457. Epub 2018 Jul 30.

a Schulze Center for Novel Therapeutics, Division of Oncology Research , Mayo Clinic , Rochester , MN , USA.

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http://dx.doi.org/10.1080/15592294.2018.1464351DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6140811PMC
February 2019

Inactivation of NUPR1 promotes cell death by coupling ER-stress responses with necrosis.

Authors:
Patricia Santofimia-Castaño Wenjun Lan Jennifer Bintz Odile Gayet Alice Carrier Gwen Lomberk José Luis Neira Antonio González Raul Urrutia Philippe Soubeyran Juan Iovanna

Sci Rep 2018 11 19;8(1):16999. Epub 2018 Nov 19.

Centre de Recherche en Cancérologie de Marseille (CRCM), INSERM U1068, CNRS UMR 7258, Aix-Marseille Université and Institut Paoli-Calmettes, Parc Scientifique et Technologique de Luminy, Marseille, France.

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http://dx.doi.org/10.1038/s41598-018-35020-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6242935PMC
November 2018

Mechanisms Underlying the Regulation of HP1γ by the NGF-PKA Signaling Pathway.

Authors:
Seungmae Seo Angela Mathison Adrienne Grzenda Jewel Podratz Ezequiel Calvo Stephen Brimijoin Anthony Windebank Juan Iovanna Gwen Lomberk Raul Urrutia

Sci Rep 2018 10 10;8(1):15077. Epub 2018 Oct 10.

Genomic Sciences and Precision Medicine Center (GSPMC), Medical College of Wisconsin, Milwaukee, WI, USA.

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http://dx.doi.org/10.1038/s41598-018-33475-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6180112PMC
October 2018

Interplay between interferon regulatory factor 1 and BRD4 in the regulation of PD-L1 in pancreatic stellate cells.

Authors:
Kazumi Ebine Krishan Kumar Thao N Pham Mario A Shields Katharine A Collier Meng Shang Brian T DeCant Raul Urrutia Rosa F Hwang Sam Grimaldo Daniel R Principe Paul J Grippo David J Bentrem Hidayatullah G Munshi

Sci Rep 2018 09 5;8(1):13225. Epub 2018 Sep 5.

Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA.

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http://dx.doi.org/10.1038/s41598-018-31658-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6125340PMC
September 2018

Effects of histone methyltransferase inhibition in endometriosis.

Authors:
Mariano Colón-Caraballo Annelyn Torres-Reverón John Lee Soto-Vargas Steven L Young Bruce Lessey Adalberto Mendoza Raúl Urrutia Idhaliz Flores

Biol Reprod 2018 08;99(2):293-307

Department of Basic Sciences-Microbiology Division, Ponce Health Sciences University, Ponce, Puerto Rico, USA.

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http://dx.doi.org/10.1093/biolre/ioy030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6373837PMC
August 2018

Co-occurrence of a maternally inherited duplication and a paternally inherited pathogenic variant in in a child with growth retardation and severe short stature: atypical Weaver syndrome or evidence of a dosage effect?

Authors:
Katarzyna Polonis Patrick R Blackburn Raul A Urrutia Gwen A Lomberk Teresa Kruisselbrink Margot A Cousin Nicole J Boczek Nicole L Hoppman Dusica Babovic-Vuksanovic Eric W Klee Pavel N Pichurin

Cold Spring Harb Mol Case Stud 2018 08 1;4(4). Epub 2018 Aug 1.

Center for Individualized Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA.

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http://dx.doi.org/10.1101/mcs.a002899DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6071565PMC
August 2018

Assessing Human Genetic Variations in Glucose Transporter SLC2A10 and Their Role in Altering Structural and Functional Properties.

Authors:
Michael T Zimmermann Raul Urrutia Margot A Cousin Gavin R Oliver Eric W Klee

Front Genet 2018 25;9:276. Epub 2018 Jul 25.

Department of Health Science Research, Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN, United States.

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http://dx.doi.org/10.3389/fgene.2018.00276DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6068234PMC
July 2018

P300 Acetyltransferase Mediates Stiffness-Induced Activation of Hepatic Stellate Cells Into Tumor-Promoting Myofibroblasts.

Authors:
Changwei Dou Zhikui Liu Kangsheng Tu Hongbin Zhang Chen Chen Usman Yaqoob Yuanguo Wang Jialing Wen Jan van Deursen Delphine Sicard Daniel Tschumperlin Hongzhi Zou Wei-Chien Huang Raul Urrutia Vijay H Shah Ningling Kang

Gastroenterology 2018 06 15;154(8):2209-2221.e14. Epub 2018 Feb 15.

Tumor Microenvironment and Metastasis, Hormel Institute, University of Minnesota, Minneapolis, Minnesota. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2018.02.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6039101PMC
June 2018

Distinct epigenetic landscapes underlie the pathobiology of pancreatic cancer subtypes.

Authors:
Gwen Lomberk Yuna Blum Rémy Nicolle Asha Nair Krutika Satish Gaonkar Laetitia Marisa Angela Mathison Zhifu Sun Huihuang Yan Nabila Elarouci Lucile Armenoult Mira Ayadi Tamas Ordog Jeong-Heon Lee Gavin Oliver Eric Klee Vincent Moutardier Odile Gayet Benjamin Bian Pauline Duconseil Marine Gilabert Martin Bigonnet Stephane Garcia Olivier Turrini Jean-Robert Delpero Marc Giovannini Philippe Grandval Mohamed Gasmi Veronique Secq Aurélien De Reyniès Nelson Dusetti Juan Iovanna Raul Urrutia

Nat Commun 2018 05 17;9(1):1978. Epub 2018 May 17.

Division of Research, Department of Surgery, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, Wisconsin, 53226, USA.

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http://dx.doi.org/10.1038/s41467-018-04383-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5958058PMC
May 2018

Vasodilator-stimulated phosphoprotein promotes liver metastasis of gastrointestinal cancer by activating a β1-integrin-FAK-YAP1/TAZ signaling pathway.

Authors:
Xiaoyu Xiang Yuanguo Wang Hongbin Zhang Jinhua Piao Selvaraj Muthusamy Lei Wang Yibin Deng Wei Zhang Rui Kuang Daniel D Billadeau Shengbing Huang Jinping Lai Raul Urrutia Ningling Kang

NPJ Precis Oncol 2018 23;2(1). Epub 2018 Jan 23.

1Tumor Microenvironment and Metastasis, The Hormel Institute, University of Minnesota, Austin, MN 55912 USA.

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http://dx.doi.org/10.1038/s41698-017-0045-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5871906PMC
January 2018

Synectin promotes fibrogenesis by regulating PDGFR isoforms through distinct mechanisms.

Authors:
Mary C Drinane Usman Yaqoob Haibin Yu Fanghong Luo Thomas Greuter Juan P Arab Enis Kostallari Vikas K Verma Jessica Maiers Thiago Milech De Assuncao Michael Simons Debabrata Mukhopadhyay Tatiana Kisseleva David A Brenner Raul Urrutia Gwen Lomberk Yandong Gao Giovanni Ligresti Daniel J Tschumperlin Alexander Revzin Sheng Cao Vijay H Shah

JCI Insight 2017 12 21;2(24). Epub 2017 Dec 21.

Gastroenterology Research Unit, Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, USA.

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http://dx.doi.org/10.1172/jci.insight.92821DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5752303PMC
December 2017

Novel variants likely disrupt DNA binding: molecular modeling in two cases, review of published cases, genotype-phenotype correlation, and phenotypic expansion of the Bosch-Boonstra-Schaaf optic atrophy syndrome.

Authors:
Charu Kaiwar Michael T Zimmermann Matthew J Ferber Zhiyv Niu Raul A Urrutia Eric W Klee Dusica Babovic-Vuksanovic

Cold Spring Harb Mol Case Stud 2017 Nov 21;3(6). Epub 2017 Nov 21.

Department of Clinical Genomics, Mayo Clinic, Rochester, Minnesota 55905, USA.

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http://dx.doi.org/10.1101/mcs.a002162DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5701304PMC
November 2017

Pancreatic Adenocarcinoma Therapeutic Targets Revealed by Tumor-Stroma Cross-Talk Analyses in Patient-Derived Xenografts.

Authors:
Rémy Nicolle Yuna Blum Laetitia Marisa Celine Loncle Odile Gayet Vincent Moutardier Olivier Turrini Marc Giovannini Benjamin Bian Martin Bigonnet Marion Rubis Nabila Elarouci Lucile Armenoult Mira Ayadi Pauline Duconseil Mohamed Gasmi Mehdi Ouaissi Aurélie Maignan Gwen Lomberk Jean-Marie Boher Jacques Ewald Erwan Bories Jonathan Garnier Anthony Goncalves Flora Poizat Jean-Luc Raoul Veronique Secq Stephane Garcia Philippe Grandval Marine Barraud-Blanc Emmanuelle Norguet Marine Gilabert Jean-Robert Delpero Julie Roques Ezequiel Calvo Fabienne Guillaumond Sophie Vasseur Raul Urrutia Aurélien de Reyniès Nelson Dusetti Juan Iovanna

Cell Rep 2017 Nov;21(9):2458-2470

Centre de Recherche en Cancérologie de Marseille (CRCM), INSERM U1068, CNRS UMR 7258, Institut Paoli-Calmettes, Aix Marseille Université, Marseille, France. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.11.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6082139PMC
November 2017

Asymmetric Cancer Hallmarks in Breast Tumors on Different Sides of the Body.

Authors:
Emanuel M Campoy Sergio R Laurito María T Branham Guillermo Urrutia Angela Mathison Francisco Gago Javier Orozco Raul Urrutia Luis S Mayorga María Roqué

PLoS One 2016 6;11(7):e0157416. Epub 2016 Jul 6.

IHEM-CONICET, Mendoza, Argentina.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0157416PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4934783PMC
August 2017

Molecular modeling and molecular dynamic simulation of the effects of variants in the TGFBR2 kinase domain as a paradigm for interpretation of variants obtained by next generation sequencing.

Authors:
Michael T Zimmermann Raul Urrutia Gavin R Oliver Patrick R Blackburn Margot A Cousin Nicole J Bozeck Eric W Klee

PLoS One 2017 9;12(2):e0170822. Epub 2017 Feb 9.

Department of Health Science Research, Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0170822PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5300139PMC
August 2017

Intrinsically disordered chromatin protein NUPR1 binds to the C-terminal region of Polycomb RING1B.

Authors:
Patricia Santofimia-Castaño Bruno Rizzuti Ángel L Pey Philippe Soubeyran Miguel Vidal Raúl Urrutia Juan L Iovanna José L Neira

Proc Natl Acad Sci U S A 2017 Aug 18;114(31):E6332-E6341. Epub 2017 Jul 18.

Instituto de Biología Molecular y Celular, Universidad Miguel Hernández, 03202 Elche, Alicante, Spain;

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http://dx.doi.org/10.1073/pnas.1619932114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5547589PMC
August 2017

Hedgehog Signaling Overcomes an EZH2-Dependent Epigenetic Barrier to Promote Cholangiocyte Expansion.

Authors:
Nidhi Jalan-Sakrikar Thiago M De Assuncao Jie Lu Luciana L Almada Gwen Lomberk Martin E Fernandez-Zapico Raul Urrutia Robert C Huebert

PLoS One 2016 9;11(12):e0168266. Epub 2016 Dec 9.

Division of Gastroenterology and Hepatology, Mayo Clinic and Foundation, Rochester, MN, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0168266PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5148157PMC
July 2017

Functional validation reveals the novel missense V419L variant in associated with Loeys-Dietz syndrome (LDS) impairs canonical TGF-β signaling.

Authors:
Margot A Cousin Michael T Zimmermann Angela J Mathison Patrick R Blackburn Nicole J Boczek Gavin R Oliver Gwen A Lomberk Raul A Urrutia David R Deyle Eric W Klee

Cold Spring Harb Mol Case Stud 2017 07 5;3(4). Epub 2017 Jul 5.

Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota 55905, USA.

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http://dx.doi.org/10.1101/mcs.a001727DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5495030PMC
July 2017

Resolution of Cochlear Inflammation: Novel Target for Preventing or Ameliorating Drug-, Noise- and Age-related Hearing Loss.

Authors:
Gilda M Kalinec Gwen Lomberk Raul A Urrutia Federico Kalinec

Front Cell Neurosci 2017 7;11:192. Epub 2017 Jul 7.

Laboratory of Auditory Cell Biology, Department of Head and Neck Surgery, David Geffen School of Medicine, University of CaliforniaLos Angeles, Los Angeles, CA, United States.

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http://dx.doi.org/10.3389/fncel.2017.00192DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5500902PMC
July 2017

Novel de novo variant in is likely to impact DNA binding in a patient with a neurodevelopmental disorder and expanded phenotypes: patient report, in silico functional assessment, and review of published cases.

Authors:
Patrick R Blackburn Sarah S Barnett Michael T Zimmermann Margot A Cousin Charu Kaiwar Filippo Pinto E Vairo Zhiyv Niu Matthew J Ferber Raul A Urrutia Duygu Selcen Eric W Klee Pavel N Pichurin

Cold Spring Harb Mol Case Stud 2017 05;3(3):a001743

Department of Clinical Genomics, Mayo Clinic, Rochester, Minnesota 55905, USA.

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http://molecularcasestudies.cshlp.org/lookup/doi/10.1101/mcs
Publisher Site
http://dx.doi.org/10.1101/mcs.a001743DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5411688PMC
May 2017

Gene expression profiling of patient-derived pancreatic cancer xenografts predicts sensitivity to the BET bromodomain inhibitor JQ1: implications for individualized medicine efforts.

Authors:
Benjamin Bian Martin Bigonnet Odile Gayet Celine Loncle Aurélie Maignan Marine Gilabert Vincent Moutardier Stephane Garcia Olivier Turrini Jean-Robert Delpero Marc Giovannini Philippe Grandval Mohamed Gasmi Mehdi Ouaissi Veronique Secq Flora Poizat Rémy Nicolle Yuna Blum Laetitia Marisa Marion Rubis Jean-Luc Raoul James E Bradner Jun Qi Gwen Lomberk Raul Urrutia Andres Saul Nelson Dusetti Juan Iovanna

EMBO Mol Med 2017 04;9(4):482-497

Centre de Recherche en Cancérologie de Marseille (CRCM), INSERM U1068, CNRS UMR 7258, Parc Scientifique et Technologique de Luminy, Aix-Marseille Université and Institut Paoli-Calmettes, Marseille, France

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http://dx.doi.org/10.15252/emmm.201606975DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5376755PMC
April 2017

A Novel Kleefstra Syndrome-associated Variant That Affects the Conserved TPL Motif within the Ankyrin Repeat of EHMT1 Leads to Abnormal Protein Folding.

Authors:
Patrick R Blackburn Alexander Tischer Michael T Zimmermann Jennifer L Kemppainen Sujatha Sastry Amy E Knight Johnson Margot A Cousin Nicole J Boczek Gavin Oliver Vinod K Misra Ralitza H Gavrilova Gwen Lomberk Matthew Auton Raul Urrutia Eric W Klee

J Biol Chem 2017 03 5;292(9):3866-3876. Epub 2017 Jan 5.

the Department of Clinical Genomics,

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http://dx.doi.org/10.1074/jbc.M116.770545DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5339767PMC
March 2017

Elucidation of -mediated Noonan syndrome with cardiac hypertrophy.

Authors:
Erin M Higgins J Martijn Bos Heather Mason-Suares David J Tester Jaeger P Ackerman Calum A MacRae Katia Sol-Church Karen W Gripp Raul Urrutia Michael J Ackerman

JCI Insight 2017 03 9;2(5):e91225. Epub 2017 Mar 9.

Department of Molecular Pharmacology and Experimental Therapeutics and Windland Smith Rice Sudden Death Genomics Laboratory.

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http://dx.doi.org/10.1172/jci.insight.91225DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5333962PMC
March 2017

A novel frameshift deletion in in a patient with Kleefstra Syndrome results in decreased H3K9 dimethylation.

Authors:
Patrick R Blackburn Monique Williams Margot A Cousin Nicole J Boczek Geoffrey J Beek Gwen A Lomberk Raul A Urrutia Dusica Babovic-Vuksanovic Eric W Klee

Mol Genet Genomic Med 2017 Mar 26;5(2):141-146. Epub 2017 Jan 26.

Center for Individualized MedicineMayo ClinicRochesterMinnesota55901; Department of Health Science ResearchMayo ClinicRochesterMinnesota55901; Department of Clinical GenomicsMayo ClinicRochesterMinnesota55901; Department of Laboratory Medicine and PathologyMayo ClinicRochesterMinnesota55901.

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http://doi.wiley.com/10.1002/mgg3.268
Publisher Site
http://dx.doi.org/10.1002/mgg3.268DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5370226PMC
March 2017

The Role of the Histone Methyltransferase Enhancer of Zeste Homolog 2 (EZH2) in the Pathobiological Mechanisms Underlying Inflammatory Bowel Disease (IBD).

Authors:
Olga F Sarmento Phyllis A Svingen Yuning Xiong Zhifu Sun Adebowale O Bamidele Angela J Mathison Thomas C Smyrk Asha A Nair Michelle M Gonzalez Mary R Sagstetter Saurabh Baheti Dermot P B McGovern Jessica J Friton Konstantinos A Papadakis Goel Gautam Ramnik J Xavier Raul A Urrutia William A Faubion

J Biol Chem 2017 Jan 1;292(2):706-722. Epub 2016 Dec 1.

From the Epigenetics and Chromatin Dynamics Laboratory, Division of Gastroenterology and Hepatology and Translational Epigenomic Program, Center for Individualized Medicine,

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http://dx.doi.org/10.1074/jbc.M116.749663DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5241744PMC
January 2017

Novel Pathogenic Variant in TGFBR2 Confirmed by Molecular Modeling Is a Rare Cause of Loeys-Dietz Syndrome.

Authors:
Michael T Zimmermann Raul A Urrutia Patrick R Blackburn Margot A Cousin Nicole J Boczek Eric W Klee Colleen Macmurdo Paldeep S Atwal

Case Rep Genet 2017 9;2017:7263780. Epub 2017 Jan 9.

Department of Clinical Genomics, Center for Individualized Medicine, Mayo Clinic, Jacksonville, FL, USA; Division of Medical Genetics, Department of Pediatrics, Stanford University, Stanford, CA, USA.

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http://dx.doi.org/10.1155/2017/7263780DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5253504PMC
January 2017

Gold Nanoparticle Reprograms Pancreatic Tumor Microenvironment and Inhibits Tumor Growth.

Authors:
Sounik Saha Xunhao Xiong Prabir K Chakraborty Khader Shameer Rochelle R Arvizo Rachel A Kudgus Shailendra Kumar Dhar Dwivedi Md Nazir Hossen Elizabeth M Gillies J David Robertson Joel T Dudley Raul A Urrutia Russell G Postier Resham Bhattacharya Priyabrata Mukherjee

ACS Nano 2016 12 19;10(12):10636-10651. Epub 2016 Oct 19.

Institute of Next Generation Healthcare, Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, Mount Sinai Health System , New York, New York 10029, United States.

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http://dx.doi.org/10.1021/acsnano.6b02231DOI Listing
December 2016

Novel roles and mechanism for Krüppel-like factor 16 (KLF16) regulation of neurite outgrowth and ephrin receptor A5 (EphA5) expression in retinal ganglion cells.

Authors:
Jianbo Wang Joana Galvao Krista M Beach Weijia Luo Raul A Urrutia Jeffrey L Goldberg Deborah C Otteson

J Biol Chem 2016 10;291(41):21422

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http://dx.doi.org/10.1074/jbc.A116.732339DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5076813PMC
October 2016

Functional characterization of a GFAP variant of uncertain significance in an Alexander disease case within the setting of an individualized medicine clinic.

Authors:
Nicole J Boczek Ashley N Sigafoos Michael T Zimmermann Rachel L Maus Margot A Cousin Patrick R Blackburn Raul Urrutia Karl J Clark Marc C Patterson Myra J Wick Eric W Klee

Clin Case Rep 2016 09 15;4(9):885-95. Epub 2016 Aug 15.

Center for Individualized Medicine Mayo Clinic Rochester Minnesota USA; Department of Biomedical Informatics Mayo Clinic Rochester Minnesota USA; Department of Clinical Genomics Mayo Clinic Rochester Minnesota USA.

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http://dx.doi.org/10.1002/ccr3.655DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5018595PMC
September 2016

Novel Roles and Mechanism for Krüppel-like Factor 16 (KLF16) Regulation of Neurite Outgrowth and Ephrin Receptor A5 (EphA5) Expression in Retinal Ganglion Cells.

Authors:
Jianbo Wang Joana Galvao Krista M Beach Weijia Luo Raul A Urrutia Jeffrey L Goldberg Deborah C Otteson

J Biol Chem 2016 08 11;291(35):18084-95. Epub 2016 Jul 11.

From the Departments of Physiological Optics and Vision Science and Biology and Biochemistry, University of Houston, Houston, Texas 77204,

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http://dx.doi.org/10.1074/jbc.M116.732339DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5000058PMC
August 2016

"The molecule's the thing:" the promise of molecular modeling and dynamic simulations in aiding the prioritization and interpretation of genomic testing results.

Authors:
Gavin R Oliver Michael T Zimmermann Eric W Klee Raul A Urrutia

F1000Res 2016 27;5:766. Epub 2016 Apr 27.

Center for Individualized Medicine, Mayo Clinic, Rochester, MN, 55905, USA; Laboratory of Epigenetics and Chromatin Dynamics, Epigenomics Translational Program, Gastroenterology Research Unit, Departments of Biochemistry and Molecular Biology, Biophysics, and Medicine, Mayo Clinic, Rochester, MN, 55905, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4920209PMC
http://dx.doi.org/10.12688/f1000research.8600.3DOI Listing
August 2016

Pancreatitis promotes oncogenic Kras(G12D)-induced pancreatic transformation through activation of Nupr1.

Authors:
Daniel Grasso Maria Noé Garcia Tewfik Hamidi Carla Cano Ezequiel Calvo Gwen Lomberk Raul Urrutia Juan L Iovanna

Mol Cell Oncol 2014 28;1(1):e29913. Epub 2014 Jul 28.

Centre de Recherche en Cancérologie de Marseille (CRCM); Aix-Marseille Université and Institut Paoli-Calmettes; Parc Scientifique et Technologique de Luminy; Marseille, France.

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http://dx.doi.org/10.4161/mco.29913DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905183PMC
June 2016

The promise of epigenomic therapeutics in pancreatic cancer.

Authors:
Gwen A Lomberk Juan Iovanna Raul Urrutia

Epigenomics 2016 06 23;8(6):831-42. Epub 2016 Jun 23.

Laboratory of Epigenetics & Chromatin Dynamics, Gastroenterology Research Unit, Departments of Biochemistry & Molecular Biology, Biophysics, & Medicine, Mayo Clinic, Rochester, MN, USA.

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http://dx.doi.org/10.2217/epi-2015-0016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5066125PMC
June 2016

REG3β Plays a Key Role in IL17RA Protumoral Effect-Response.

Authors:
Celine Loncle Laia Bonjoch Emma Folch-Puy Maria Belen Lopez-Millan Sophie Lac Maria Inés Molejon Eduardo Chuluyan Pierre Cordelier Pierre Dubus Gwen Lomberk Raul Urrutia Daniel Closa Juan L Iovanna

Cancer Res 2016 04 18;76(7):2051. Epub 2016 Mar 18.

Centre de Recherche en Cancérologie de Marseille (CRCM), INSERM U1068, CNRS UMR 7258, Aix-Marseille Université and Institut Paoli-Calmettes, Parc Scientifique et Technologique de Luminy, Marseille, France.

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http://dx.doi.org/10.1158/0008-5472.CAN-15-3355DOI Listing
April 2016

Evidence supporting a critical contribution of intrinsically disordered regions to the biochemical behavior of full-length human HP1γ.

Authors:
Gabriel Velez Marisa Lin Trace Christensen William A Faubion Gwen Lomberk Raul Urrutia

J Mol Model 2016 Jan 17;22(1):12. Epub 2015 Dec 17.

Laboratory of Epigenetics and Chromatin Dynamics, Gastroenterology Research Unit, Department of Biochemistry and Molecular Biology, Mayo Clinic, 200 First Street SW, Guggenheim 10, Rochester, MN, 55905, USA.

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http://dx.doi.org/10.1007/s00894-015-2874-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4683166PMC
January 2016

Functional Characterization of Nupr1L, A Novel p53-Regulated Isoform of the High-Mobility Group (HMG)-Related Protumoral Protein Nupr1.

Authors:
Maria Belen Lopez Maria Noé Garcia Daniel Grasso Jennifer Bintz Maria Inés Molejon Gabriel Velez Gwen Lomberk Jose Luis Neira Raul Urrutia Juan Iovanna

J Cell Physiol 2015 Dec;230(12):2936-50

Centre de Recherche en Cancérologie de Marseille (CRCM), INSERM U1068, CNRS UMR 7258, Aix-Marseille Université and Institut Paoli-Calmettes, Parc Scientifique et Technologique de Luminy, Marseille, France.

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http://dx.doi.org/10.1002/jcp.25022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4778741PMC
December 2015

Biology and pathobiology of lipid droplets and their potential role in the protection of the organ of Corti.

Authors:
Raul A Urrutia Federico Kalinec

Hear Res 2015 Dec 15;330(Pt A):26-38. Epub 2015 May 15.

Laboratory of Auditory Cell Biology, Department of Head & Neck Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA. Electronic address:

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http://dx.doi.org/10.1016/j.heares.2015.04.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5391798PMC
December 2015

Krüppel-like factor KLF10 deficiency predisposes to colitis through colonic macrophage dysregulation.

Authors:
Konstantinos A Papadakis James Krempski Phyllis Svingen Yuning Xiong Olga F Sarmento Gwen A Lomberk Raul A Urrutia William A Faubion

Am J Physiol Gastrointest Liver Physiol 2015 Dec 15;309(11):G900-9. Epub 2015 Oct 15.

Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota; and.

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http://dx.doi.org/10.1152/ajpgi.00309.2015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4669350PMC
December 2015

IL17 Functions through the Novel REG3β-JAK2-STAT3 Inflammatory Pathway to Promote the Transition from Chronic Pancreatitis to Pancreatic Cancer.

Authors:
Celine Loncle Laia Bonjoch Emma Folch-Puy Maria Belen Lopez-Millan Sophie Lac Maria Inés Molejon Eduardo Chuluyan Pierre Cordelier Pierre Dubus Gwen Lomberk Raul Urrutia Daniel Closa Juan L Iovanna

Cancer Res 2015 Nov 24;75(22):4852-62. Epub 2015 Sep 24.

Centre de Recherche en Cancérologie de Marseille (CRCM), INSERM U1068, CNRS UMR 7258, Aix-Marseille Université and Institut Paoli-Calmettes, Parc Scientifique et Technologique de Luminy, Marseille, France.

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http://dx.doi.org/10.1158/0008-5472.CAN-15-0896DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4651828PMC
November 2015

Pivotal Role of the Chromatin Protein Nupr1 in Kras-Induced Senescence and Transformation.

Authors:
Daniel Grasso Jennifer Bintz Gwen Lomberk Maria Ines Molejon Celine Loncle Maria Noé Garcia Maria Belen Lopez Raul Urrutia Juan L Iovanna

Sci Rep 2015 Nov 30;5:17549. Epub 2015 Nov 30.

Centre de Recherche en Cancérologie de Marseille (CRCM), INSERM U1068, CNRS UMR 7258, Aix-Marseille Université and Institut Paoli-Calmettes, Parc Scientifique et Technologique de Luminy, Marseille, France.

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http://dx.doi.org/10.1038/srep17549DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4663475PMC
November 2015

Phenotypic Characterization of Mice Carrying Homozygous Deletion of KLF11, a Gene in Which Mutations Cause Human Neonatal and MODY VII Diabetes.

Authors:
Angela Mathison Carlos Escande Ezequiel Calvo Seungmae Seo Thomas White Ann Salmonson William A Faubion Navtej Buttar Juan Iovanna Gwen Lomberk Eduardo N Chini Raul Urrutia

Endocrinology 2015 Oct 6;156(10):3581-95. Epub 2015 Aug 6.

Laboratory of Epigenetics and Chromatin Dynamics (A.M., A.S., W.A.F., N.B., G.L., R.U.), Gastroenterology Research Unit, Departments of Biochemistry and Molecular Biology, Biophysics, Medicine, Epigenomics Translation Program Center for Individualized Medicine, Mayo Clinic, Rochester, Minnesota 55905; Metabolic Diseases and Aging Laboratory (C.E.), Institut Pasteur Montevideo, Montevideo 11400, Uruguay; Department of Anesthesia and Robert and Arlene Kogod Center on Aging (C.E., T.W., E.N.C.), Mayo Clinic, Rochester, Minnesota 55905; Endocrinology and Nephrology (E.C.), Centre Hospitalier Universitaire de Québec Research Center and Laval University, Québec, Québec, G1V 4G2, Canada; Lieber Institute for Brain Development (S.S.), Baltimore, Maryland 21205; and Centre de Recherche en Cancérologie de Marseille (J.I.), INSERM U1068, Centre Nationale de la Recherche Scientifique Unité Mixte de Recherche 7258, Aix-Marseille Université and Institut Paoli-Calmettes, Parc Scientifique et Technologique de Luminy, Marseille, 13288, France.

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http://dx.doi.org/10.1210/en.2015-1145DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4588811PMC
October 2015

The Triple-Code Model for Pancreatic Cancer: Cross Talk Among Genetics, Epigenetics, and Nuclear Structure.

Authors:
Gwen A Lomberk Raul Urrutia

Surg Clin North Am 2015 Oct 23;95(5):935-52. Epub 2015 Jul 23.

Laboratory of Epigenetics and Chromatin Dynamics, Gastroenterology Research Unit, Department of Biochemistry and Molecular Biology, Mayo Clinic, Guggenheim 10-42C, Rochester, MN 55905, USA; Laboratory of Epigenetics and Chromatin Dynamics, Gastroenterology Research Unit, Department of Biophysics, Mayo Clinic, Guggenheim 10-42C, Rochester, MN 55905, USA; Laboratory of Epigenetics and Chromatin Dynamics, Gastroenterology Research Unit, Department of Medicine, Mayo Clinic, Guggenheim 10-42C, Rochester, MN 55905, USA. Electronic address:

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http://dx.doi.org/10.1016/j.suc.2015.05.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4556141PMC
October 2015

Perhexiline activates KLF14 and reduces atherosclerosis by modulating ApoA-I production.

Authors:
Yanhong Guo Yanbo Fan Jifeng Zhang Gwen A Lomberk Zhou Zhou Lijie Sun Angela J Mathison Minerva T Garcia-Barrio Ji Zhang Lixia Zeng Lei Li Subramaniam Pennathur Cristen J Willer Daniel J Rader Raul Urrutia Y Eugene Chen

J Clin Invest 2015 Oct 14;125(10):3819-30. Epub 2015 Sep 14.

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http://dx.doi.org/10.1172/JCI79048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4607137PMC
October 2015

Development and characterization of human-induced pluripotent stem cell-derived cholangiocytes.

Authors:
Thiago M De Assuncao Yan Sun Nidhi Jalan-Sakrikar Mary C Drinane Bing Q Huang Ying Li Jaime I Davila Ruisi Wang Steven P O'Hara Gwen A Lomberk Raul A Urrutia Yasuhiro Ikeda Robert C Huebert

Lab Invest 2015 Oct;95(10):1218

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http://dx.doi.org/10.1038/labinvest.2015.99DOI Listing
October 2015

Development and characterization of human-induced pluripotent stem cell-derived cholangiocytes.

Authors:
Thiago M De Assuncao Yan Sun Nidhi Jalan-Sakrikar Mary C Drinane Bing Q Huang Ying Li Jaime I Davila Ruisi Wang Steven P O'Hara Gwen A Lomberk Raul A Urrutia Yasuhiro Ikeda Robert C Huebert

Lab Invest 2015 Jun 13;95(6):684-96. Epub 2015 Apr 13.

1] Division of Gastroenterology and Hepatology, Mayo Clinic and Foundation, Rochester, MN, USA [2] Gastroenterology Research Unit, Mayo Clinic and Foundation, Rochester, MN, USA [3] Center for Cell Signaling in Gastroenterology, Mayo Clinic and Foundation, Rochester, MN, USA.

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http://dx.doi.org/10.1038/labinvest.2015.51DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4447567PMC
June 2015

Evidence revealing deregulation of the KLF11-MAO A pathway in association with chronic stress and depressive disorders.

Authors:
Sharonda Harris Shakevia Johnson Jeremy W Duncan Chinelo Udemgba Jeffrey H Meyer Paul R Albert Gwen Lomberk Raul Urrutia Xiao-Ming Ou Craig A Stockmeier Jun Ming Wang

Neuropsychopharmacology 2015 May 15;40(6):1373-82. Epub 2014 Dec 15.

1] Department of Psychiatry and Human Behavior, Jackson, MS, USA [2] Program in Neuroscience, Jackson, MS, USA [3] Department of Pathology, University of Mississippi Medical Center, Jackson, MS, USA.

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http://dx.doi.org/10.1038/npp.2014.321DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4397395PMC
May 2015

The Aurora A-HP1γ pathway regulates gene expression and mitosis in cells from the sperm lineage.

Authors:
Phoebe H Leonard Adrienne Grzenda Angela Mathison Dean E Morbeck Jolene R Fredrickson Thiago M de Assuncao Trace Christensen Jeffrey Salisbury Ezequiel Calvo Juan Iovanna Charles C Coddington Raul Urrutia Gwen Lomberk

BMC Dev Biol 2015 May 29;15:23. Epub 2015 May 29.

Department of Medicine, Mayo Clinic, Laboratory of Epigenetics and Chromatin Dynamics, Gastroenterology Research Unit, Guggenheim 10, 200 First Street SW, Rochester, MN, 55905, USA.

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http://dx.doi.org/10.1186/s12861-015-0073-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4448908PMC
May 2015

Membrane-to-Nucleus Signals and Epigenetic Mechanisms for Myofibroblastic Activation and Desmoplastic Stroma: Potential Therapeutic Targets for Liver Metastasis?

Authors:
Ningling Kang Vijay H Shah Raul Urrutia

Mol Cancer Res 2015 Apr 29;13(4):604-12. Epub 2014 Dec 29.

GI Research Unit, Division of Gastroenterology and Hepatology, Epigenomics Translational Program, Center for Individualized Medicine, Mayo Clinic, Rochester, Minnesota.

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http://dx.doi.org/10.1158/1541-7786.MCR-14-0542DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4398610PMC
April 2015

Krüppel-like factor KLF10 regulates transforming growth factor receptor II expression and TGF-β signaling in CD8+ T lymphocytes.

Authors:
Konstantinos A Papadakis James Krempski Jesse Reiter Phyllis Svingen Yuning Xiong Olga F Sarmento April Huseby Aaron J Johnson Gwen A Lomberk Raul A Urrutia William A Faubion

Am J Physiol Cell Physiol 2015 Mar 3;308(5):C362-71. Epub 2014 Dec 3.

Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota;

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http://dx.doi.org/10.1152/ajpcell.00262.2014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346734PMC
March 2015

Gestational diabetes mellitus impairs fetal endothelial cell functions through a mechanism involving microRNA-101 and histone methyltransferase enhancer of zester homolog-2.

Authors:
Ilaria Floris Betty Descamps Antonella Vardeu Tijana Mitić Anna Maria Posadino Saran Shantikumar Graciela Sala-Newby Gianpiero Capobianco Giuseppe Mangialardi Lynsey Howard Salvatore Dessole Raul Urrutia Gianfranco Pintus Costanza Emanueli

Arterioscler Thromb Vasc Biol 2015 Mar 22;35(3):664-74. Epub 2015 Jan 22.

From the Bristol Heart Institute, School of Clinical Sciences, University of Bristol, Bristol, United Kingdom (I.F., B.D., A.V., T.M., S.S., G.S.-N., G.M., L.H., C.E.); Laboratory of Vascular Biology, Department of Biomedical Science (I.F., A.V., M.P., G.P.) and Department of Obstetrics and Gynecology Unit (G.C., S.D.), University of Sassari, Sassari, Italy; Laboratory of Epigenetics and Chromatin Dynamics, Mayo Clinic, Rochester, MN (R.U.); and National Heart and Lung Institute, Imperial College London, London, United Kingdom (C.E.).

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http://dx.doi.org/10.1161/ATVBAHA.114.304730DOI Listing
March 2015

A novel role for KLF14 in T regulatory cell differentiation.

Authors:
Olga F Sarmento Phyllis A Svingen Yuning Xiong Ramnik J Xavier Dermot McGovern Thomas C Smyrk Konstantinos A Papadakis Raul A Urrutia William A Faubion

Cell Mol Gastroenterol Hepatol 2015 Mar;1(2):188-202.e4

Epigenetics and Chromatin Dynamics Laboratory, Division of Gastroenterology and Hepatology and Translational Epigenomic Program, Center for Individualized Medicine (CIM), Mayo Clinic Rochester.

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http://dx.doi.org/10.1016/j.jcmgh.2014.12.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4349492PMC
March 2015

EZH2 modulates angiogenesis in vitro and in a mouse model of limb ischemia.

Authors:
Tijana Mitić Andrea Caporali Ilaria Floris Marco Meloni Micol Marchetti Raul Urrutia Gianni D Angelini Costanza Emanueli

Mol Ther 2015 Jan 5;23(1):32-42. Epub 2014 Sep 5.

1] Bristol Heart Institute, School of Clinical Sciences, University of Bristol, England, UK [2] National Heart and Lung Institute, Hammersmith Campus, Imperial College of London, London, England, UK.

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http://dx.doi.org/10.1038/mt.2014.163DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4426795PMC
January 2015

Browning of human adipocytes requires KLF11 and reprogramming of PPARγ superenhancers.

Authors:
Anne Loft Isabel Forss Majken Storm Siersbæk Søren Fisker Schmidt Ann-Sofie Bøgh Larsen Jesper Grud Skat Madsen Didier F Pisani Ronni Nielsen Mads Malik Aagaard Angela Mathison Matt J Neville Raul Urrutia Fredrik Karpe Ez-Zoubir Amri Susanne Mandrup

Genes Dev 2015 Jan 12;29(1):7-22. Epub 2014 Dec 12.

Department of Biochemistry and Molecular Biology, University of Southern Denmark, DK-5230 Odense M, Denmark;

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http://dx.doi.org/10.1101/gad.250829.114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4281566PMC
January 2015

Krüppel-like factor 9 promotes hepatic cytochrome P450 2D6 expression during pregnancy in CYP2D6-humanized mice.

Authors:
Kwi Hye Koh Xian Pan Wei Zhang Alan McLachlan Raul Urrutia Hyunyoung Jeong

Mol Pharmacol 2014 Dec 12;86(6):727-35. Epub 2014 Sep 12.

Department of Pharmacy Practice (K.H.K., H.J.), Department of Biopharmaceutical Sciences (X.P., H.J.), College of Pharmacy, and Department of Pediatrics (W.Z.) and Department of Microbiology and Immunology (A.M.), College of Medicine, University of Illinois at Chicago, Chicago, Illinois; and Laboratory of Epigenetics and Chromatin Dynamics, and Departments of Biology and Molecular Biology, Epigenomics Translational Program, Mayo Clinic Center for Individualized Medicine, Mayo Clinic, Rochester, Minnesota (R.U.)

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http://dx.doi.org/10.1124/mol.114.093666DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4244597PMC
December 2014

IER3 supports KRASG12D-dependent pancreatic cancer development by sustaining ERK1/2 phosphorylation.

Authors:
Maria Noé Garcia Daniel Grasso Maria Belen Lopez-Millan Tewfik Hamidi Celine Loncle Richard Tomasini Gwen Lomberk Françoise Porteu Raul Urrutia Juan L Iovanna

J Clin Invest 2014 Nov 24;124(11):4709-22. Epub 2014 Sep 24.

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http://www.jci.org/articles/view/76037
Publisher Site
http://dx.doi.org/10.1172/JCI76037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4347237PMC
November 2014

Deleted in Breast Cancer 1 regulates cellular senescence during obesity.

Authors:
Carlos Escande Veronica Nin Tamar Pirtskhalava Claudia C Chini Maria Thereza Barbosa Angela Mathison Raul Urrutia Tamar Tchkonia James L Kirkland Eduardo N Chini

Aging Cell 2014 Oct 3;13(5):951-3. Epub 2014 Jul 3.

Department of Anesthesia, Mayo Clinic, Rochester, MN, USA; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA; Institut Pasteur Montevideo, Montevideo, Uruguay.

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http://doi.wiley.com/10.1111/acel.12235
Publisher Site
http://dx.doi.org/10.1111/acel.12235DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4172532PMC
October 2014

Differential coupling of KLF10 to Sin3-HDAC and PCAF regulates the inducibility of the FOXP3 gene.

Authors:
Yuning Xiong Phyllis A Svingen Olga O Sarmento Thomas C Smyrk Maneesh Dave Sahil Khanna Gwen A Lomberk Raul A Urrutia William A Faubion

Am J Physiol Regul Integr Comp Physiol 2014 Sep 18;307(6):R608-20. Epub 2014 Jun 18.

Epigenetics and Chromatin Dynamics Laboratory, Mayo Clinic, Rochester, Minnesota; Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota; Translational Epigenomic Program, Center for Individualized Medicine, Mayo Clinic, Rochester, Minnesota; and

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http://dx.doi.org/10.1152/ajpregu.00085.2014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4166759PMC
September 2014

Membrane-to-nucleus signaling links insulin-like growth factor-1- and stem cell factor-activated pathways.

Authors:
Yujiro Hayashi David T Asuzu Simon J Gibbons Kirsten H Aarsvold Michael R Bardsley Gwen A Lomberk Angela J Mathison Michael L Kendrick K Robert Shen Takahiro Taguchi Anu Gupta Brian P Rubin Jonathan A Fletcher Gianrico Farrugia Raul A Urrutia Tamas Ordog

PLoS One 2013 7;8(10):e76822. Epub 2013 Oct 7.

Enteric Neuroscience Program, Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, United States of America ; Gastroenterology Research Unit, Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0076822PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3792098PMC
August 2014

Evidence supporting the existence of a NUPR1-like family of helix-loop-helix chromatin proteins related to, yet distinct from, AT hook-containing HMG proteins.

Authors:
Raul Urrutia Gabriel Velez Marisa Lin Gwen Lomberk Jose Luis Neira Juan Iovanna

J Mol Model 2014 Aug 24;20(8):2357. Epub 2014 Jul 24.

Laboratory of Epigenetics and Chromatin Dynamics, Departments of Biochemistry and Molecular Biology, Biophysics, and Medicine, Epigenomics Translational Program, Center for Individualized Medicine., Mayo Clinic, 200 First Street SW, Guggenheim 10, Rochester, MN, 55905, USA,

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http://dx.doi.org/10.1007/s00894-014-2357-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4139591PMC
August 2014

Acetaminophen and NAPQI are toxic to auditory cells via oxidative and endoplasmic reticulum stress-dependent pathways.

Authors:
Gilda M Kalinec Pru Thein Arya Parsa Joshua Yorgason William Luxford Raul Urrutia Federico Kalinec

Hear Res 2014 Jul 30;313:26-37. Epub 2014 Apr 30.

Department of Head & Neck Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA. Electronic address:

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http://dx.doi.org/10.1016/j.heares.2014.04.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4084927PMC
July 2014

Genetic inactivation of Nupr1 acts as a dominant suppressor event in a two-hit model of pancreatic carcinogenesis.

Authors:
Carla E Cano Tewfik Hamidi Maria Noé Garcia Daniel Grasso Céline Loncle Stéphane Garcia Ezequiel Calvo Gwen Lomberk Nelson Dusetti Laurent Bartholin Raul Urrutia Juan L Iovanna

Gut 2014 Jun 11;63(6):984-95. Epub 2013 Sep 11.

Centre de Recherche en Carcérologie de Marseille (CRCM), INSERM UMR 1068, CNRS UMR 7258, Aix-Marseille University and Institut Paoli-Calmettes, Parc Scientifique et Technologique de Luminy, , Marseille, France.

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June 2014

Role for Krüppel-like transcription factor 11 in mesenchymal cell function and fibrosis.

Authors:
Angela Mathison Adrienne Grzenda Gwen Lomberk Gabriel Velez Navtej Buttar Pamela Tietz Helen Hendrickson Ann Liebl Yuning Y Xiong Gregory Gores Martin Fernandez-Zapico Nicholas F Larusso William Faubion Vijay H Shah Raul Urrutia

PLoS One 2013 17;8(9):e75311. Epub 2013 Sep 17.

Laboratory of Epigenetics and Chromatin Dynamics, Mayo Clinic, Rochester, Minnesota, United States of America ; Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, United States of America.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3775729PMC
June 2014

Inflammation-induced NFATc1-STAT3 transcription complex promotes pancreatic cancer initiation by KrasG12D.

Authors:
Sandra Baumgart Nai-Ming Chen Jens T Siveke Alexander König Jin-San Zhang Shiv K Singh Elmar Wolf Marek Bartkuhn Irene Esposito Elisabeth Heßmann Johanna Reinecke Julius Nikorowitsch Marius Brunner Garima Singh Martin E Fernandez-Zapico Thomas Smyrk William R Bamlet Martin Eilers Albrecht Neesse Thomas M Gress Daniel D Billadeau David Tuveson Raul Urrutia Volker Ellenrieder

Cancer Discov 2014 Jun 2;4(6):688-701. Epub 2014 Apr 2.

Authors' Affiliations:Signaling and Transcription Laboratory, Department of Gastroenterology, Philipps University, Marburg; Department of Gastroenterology and Gastrointestinal Oncology, University Medical Center Göttingen, Göttingen; II. Medizinische Klinik, Klinikum rechts der Isar, Technische Universität; Institute of Pathology, Helmholtz Zentrum, Munich; Theodor Boveri Institute, University of Würzburg, Würzburg; Institute for Genetics, Justus-Liebig-University, Giessen, Germany; Schulze Center for Novel Therapeutics, Division of Oncology Research; Divisions of Anatomic Pathology and Biostatistics, College of Medicine; Laboratory of Epigenetics and Chromatin Dynamics, Department of Medicine, Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota; Barrow Brain Tumor Research Center, St. Joseph's Hospital and Medical Center, Phoenix, Arizona; and Cold Spring Harbor Laboratory, Cold Spring Harbor, New York

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http://dx.doi.org/10.1158/2159-8290.CD-13-0593DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4069603PMC
June 2014

New role for Kruppel-like factor 14 as a transcriptional activator involved in the generation of signaling lipids.

Authors:
Thiago M de Assuncao Gwen Lomberk Sheng Cao Usman Yaqoob Angela Mathison Douglas A Simonetto Robert C Huebert Raul A Urrutia Vijay H Shah

J Biol Chem 2014 May 23;289(22):15798-809. Epub 2014 Apr 23.

From the Gastroenterology Research Unit, Departments of Biochemistry and Molecular Biology, Physiology and Biophysics, and Medicine and

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http://dx.doi.org/10.1074/jbc.M113.544346DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4140934PMC
May 2014

Single and combinatorial chromatin coupling events underlies the function of transcript factor Krüppel-like factor 11 in the regulation of gene networks.

Authors:
Ezequiel Calvo Adrienne Grzenda Gwen Lomberk Angela Mathison Juan Iovanna Raul Urrutia

BMC Mol Biol 2014 May 25;15:10. Epub 2014 May 25.

Laboratory of Epigenetics and Chromatin Dynamics, Mayo Clinic, Rochester, MN 55905, USA.

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http://dx.doi.org/10.1186/1471-2199-15-10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4049485PMC
May 2014

Diabetes-causing gene, kruppel-like factor 11, modulates the antinociceptive response of chronic ethanol intake.

Authors:
Xiao-Ming Ou Chinelo Udemgba Niping Wang Xiaoli Dai Gwen Lomberk Seungmae Seo Raul Urrutia Junming Wang Jeremy Duncan Sharonda Harris Carolyn A Fairbanks Xiao Zhang

Alcohol Clin Exp Res 2014 Feb 15;38(2):401-8. Epub 2014 Jan 15.

Department of Psychiatry and Human Behavior , University of Mississippi Medical Center, Jackson, Mississippi.

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http://dx.doi.org/10.1111/acer.12258DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5567722PMC
February 2014

Novel role of VMP1 as modifier of the pancreatic tumor cell response to chemotherapeutic drugs.

Authors:
Marine Gilabert Maria Inés Vaccaro Martin E Fernandez-Zapico Ezequiel L Calvo Olivier Turrini Véronique Secq Stéphane Garcia Vincent Moutardier Gwen Lomberk Nelson Dusetti Raul Urrutia Juan L Iovanna

J Cell Physiol 2013 Sep;228(9):1834-43

Cancer Research Center of Marseille, INSERM U624, Marseille, France.

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http://dx.doi.org/10.1002/jcp.24343DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4048029PMC
September 2013

A novel role of the Sp/KLF transcription factor KLF11 in arresting progression of endometriosis.

Authors:
Gaurang S Daftary Ye Zheng Zaid M Tabbaa John K Schoolmeester Ravi P Gada Adrienne L Grzenda Angela J Mathison Gary L Keeney Gwen A Lomberk Raul Urrutia

PLoS One 2013 28;8(3):e60165. Epub 2013 Mar 28.

Laboratory of Translational Epigenetics in Reproduction, Department of Obstetrics and Gynecology, Mayo Clinic, Rochester, MN, USA.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0060165PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3610699PMC
September 2013

Functional impact of Aurora A-mediated phosphorylation of HP1γ at serine 83 during cell cycle progression.

Authors:
Adrienne Grzenda Phoebe Leonard Seungmae Seo Angela J Mathison Guillermo Urrutia Ezequiel Calvo Juan Iovanna Raul Urrutia Gwen Lomberk

Epigenetics Chromatin 2013 Jul 5;6(1):21. Epub 2013 Jul 5.

Laboratory of Epigenetics and Chromatin Dynamics, GIH Division, Department of Medicine, Biochemistry and Molecular Biology, Guggenheim 10, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.

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http://dx.doi.org/10.1186/1756-8935-6-21DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3707784PMC
July 2013

Krüppel-like factor 11 regulates the expression of metabolic genes via an evolutionarily conserved protein interaction domain functionally disrupted in maturity onset diabetes of the young.

Authors:
Gwen Lomberk Adrienne Grzenda Angela Mathison Carlos Escande Jin-San Zhang Ezequiel Calvo Laurence J Miller Juan Iovanna Eduardo N Chini Martin E Fernandez-Zapico Raul Urrutia

J Biol Chem 2013 Jun 15;288(24):17745-58. Epub 2013 Apr 15.

Laboratory of Epigenetics and Chromatin Dynamics, Epigenomics Translational Program, Mayo Clinic Center for Individualized Medicine, Division of Gastroenterology and Hepatology, and Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota 55905, USA.

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http://dx.doi.org/10.1074/jbc.M112.434670DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3682574PMC
June 2013

Epigenetics: a promising paradigm for better understanding and managing pain.

Authors:
Seungmae Seo Adrienne Grzenda Gwen Lomberk Xiao-Ming Ou Ricardo A Cruciani Raul Urrutia

J Pain 2013 Jun 19;14(6):549-57. Epub 2013 Apr 19.

Laboratory of Epigenetics and Chromatin Dynamics, Translational Epigenomic Program, Center for Individualized Medicine, GIH Division, Department of Medicine, Physiology, Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota, USA.

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http://dx.doi.org/10.1016/j.jpain.2013.01.772DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3672350PMC
June 2013

Cross-species analysis of nicotine-induced proteomic alterations in pancreatic cells.

Authors:
Joao A Paulo Raul Urrutia Vivek Kadiyala Peter Banks Darwin L Conwell Hanno Steen

Proteomics 2013 May;13(9):1499-1512

Department of Pathology, Children's Hospital Boston and Harvard Medical School, Boston, MA Proteomics Center at Children's Hospital Boston, Boston, MA.

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http://dx.doi.org/10.1002/pmic.201200492DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4036444PMC
May 2013

Mechanistic insights into self-reinforcing processes driving abnormal histogenesis during the development of pancreatic cancer.

Authors:
Juan L Iovanna David L Marks Martin E Fernandez-Zapico Raul Urrutia

Am J Pathol 2013 Apr 31;182(4):1078-86. Epub 2013 Jan 31.

Cancer Research Center of Marseille, Inserm U1068, CNRS, UMR7258, Institute Paoli-Calmettes, Aix-Marseille University, Marseille, France.

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http://dx.doi.org/10.1016/j.ajpath.2012.12.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3969507PMC
April 2013

KLF11 mediates PPARγ cerebrovascular protection in ischaemic stroke.

Authors:
Ke-Jie Yin Yanbo Fan Milton Hamblin Jifeng Zhang Tainqing Zhu Siming Li John R Hawse Malayannan Subramaniam Chao-Zhong Song Raul Urrutia Jiandie D Lin Y Eugene Chen

Brain 2013 Apr 12;136(Pt 4):1274-87. Epub 2013 Feb 12.

Cardiovascular Centre, Department of Internal Medicine, University of Michigan Medical Centre, NCRC Bld 26, Rm 361S, 2800 Plymouth Rd, Ann Arbor, MI 48109, USA.

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https://academic.oup.com/brain/article-lookup/doi/10.1093/br
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http://dx.doi.org/10.1093/brain/awt002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3613710PMC
April 2013

Functional characterization of EZH2β reveals the increased complexity of EZH2 isoforms involved in the regulation of mammalian gene expression.

Authors:
Adrienne Grzenda Gwen Lomberk Phyllis Svingen Angela Mathison Ezequiel Calvo Juan Iovanna Yuning Xiong William Faubion Raul Urrutia

Epigenetics Chromatin 2013 Feb 28;6(1). Epub 2013 Feb 28.

Laboratory of Epigenetics and Chromatin Dynamics, Mayo Clinic, Rochester, MN, 55905, USA.

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http://dx.doi.org/10.1186/1756-8935-6-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3606351PMC
February 2013

NUPR1 works against the metabolic stress-induced autophagy-associated cell death in pancreatic cancer cells.

Authors:
Tewfik Hamidi Carla E Cano Daniel Grasso Maria Noé Garcia Maria José Sandi Ezequiel L Calvo Jean-Charles Dagorn Gwen Lomberk Sandro Goruppi Raul Urrutia Arkaitz Carracedo Guillermo Velasco Juan L Iovanna

Autophagy 2013 Jan 9;9(1):95-7. Epub 2012 Oct 9.

Cancer Research Center of Marseille, INSERM U1068, Marseille, France.

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http://dx.doi.org/10.4161/auto.22258DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3542222PMC
January 2013

Insights into the epigenetic mechanisms controlling pancreatic carcinogenesis.

Authors:
Angela L McCleary-Wheeler Gwen A Lomberk Frank U Weiss Günter Schneider Muller Fabbri Tara L Poshusta Nelson J Dusetti Sandra Baumgart Juan L Iovanna Volker Ellenrieder Raul Urrutia Martin E Fernandez-Zapico

Cancer Lett 2013 Jan 13;328(2):212-21. Epub 2012 Oct 13.

Schulze Center for Novel Therapeutics, Division of Oncology Research, Department of Oncology, Rochester, MN, USA.

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http://dx.doi.org/10.1016/j.canlet.2012.10.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3513548PMC
January 2013

Krüppel-like factor-11, a transcription factor involved in diabetes mellitus, suppresses endothelial cell activation via the nuclear factor-κB signaling pathway.

Authors:
Yanbo Fan Yanhong Guo Jifeng Zhang Malayannan Subramaniam Chao-Zhong Song Raul Urrutia Y Eugene Chen

Arterioscler Thromb Vasc Biol 2012 Dec 4;32(12):2981-8. Epub 2012 Oct 4.

Cardiovascular Center, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, MI 48109, USA.

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http://dx.doi.org/10.1161/ATVBAHA.112.300349DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3556387PMC
December 2012

Polycomb antagonizes p300/CREB-binding protein-associated factor to silence FOXP3 in a Kruppel-like factor-dependent manner.

Authors:
Yuning Xiong Sahil Khanna Adrienne L Grzenda Olga F Sarmento Phyllis A Svingen Gwen A Lomberk Raul A Urrutia William A Faubion

J Biol Chem 2012 Oct 15;287(41):34372-85. Epub 2012 Aug 15.

Chromatin Dynamics and Epigenetics Laboratory, Mayo Clinic, Rochester, Minnesota 55905, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M111.325332
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http://dx.doi.org/10.1074/jbc.M111.325332DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3464543PMC
October 2012

Nupr1-aurora kinase A pathway provides protection against metabolic stress-mediated autophagic-associated cell death.

Authors:
Tewfik Hamidi Carla E Cano Daniel Grasso Maria Noé Garcia Maria José Sandi Ezequiel L Calvo Jean-Charles Dagorn Gwen Lomberk Raul Urrutia Sandro Goruppi Arkaitz Carracedo Guillermo Velasco Juan L Iovanna

Clin Cancer Res 2012 Oct 16;18(19):5234-46. Epub 2012 Aug 16.

Stress Cellulaire, Parc Scientifique et Technologique de Luminy, Marseille, France.

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http://dx.doi.org/10.1158/1078-0432.CCR-12-0026DOI Listing
October 2012

Homotypic cell cannibalism, a cell-death process regulated by the nuclear protein 1, opposes to metastasis in pancreatic cancer.

Authors:
Carla E Cano María José Sandí Tewfik Hamidi Ezequiel L Calvo Olivier Turrini Laurent Bartholin Céline Loncle Véronique Secq Stéphane Garcia Gwen Lomberk Guido Kroemer Raul Urrutia Juan L Iovanna

EMBO Mol Med 2012 Sep 23;4(9):964-79. Epub 2012 Jul 23.

INSERM U, CRCM, Cell Stress, Marseille, France.

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http://embomolmed.embopress.org/cgi/doi/10.1002/emmm.2012012
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http://dx.doi.org/10.1002/emmm.201201255DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3491828PMC
September 2012

Inhibition of histone deacetylation potentiates the evolution of acquired temozolomide resistance linked to MGMT upregulation in glioblastoma xenografts.

Authors:
Gaspar J Kitange Ann C Mladek Brett L Carlson Mark A Schroeder Jenny L Pokorny Ling Cen Paul A Decker Wenting Wu Gwen A Lomberk Shiv K Gupta Raul A Urrutia Jann N Sarkaria

Clin Cancer Res 2012 Aug 6;18(15):4070-9. Epub 2012 Jun 6.

Department of Radiation Oncology, Mayo Clinic, Rochester, Minnesota 55905, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-12-0560DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3716364PMC
August 2012

Mechanistic role for a novel glucocorticoid-KLF11 (TIEG2) protein pathway in stress-induced monoamine oxidase A expression.

Authors:
Matthew Grunewald Shakevia Johnson Deyin Lu Zhe Wang Gwen Lomberk Paul R Albert Craig A Stockmeier Jeffrey H Meyer Raul Urrutia Klaus A Miczek Mark C Austin Junming Wang Ian A Paul William L Woolverton Seungmae Seo Donald B Sittman Xiao-Ming Ou

J Biol Chem 2012 Jul 24;287(29):24195-206. Epub 2012 May 24.

Department of Psychiatry and Human Behavior, University of Mississippi Medical Center, Jackson, Mississippi 39216, USA.

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http://dx.doi.org/10.1074/jbc.M112.373936DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3397846PMC
July 2012

Nuclear protein 1 promotes pancreatic cancer development and protects cells from stress by inhibiting apoptosis.

Authors:
Tewfik Hamidi Hana Algül Carla Eliana Cano Maria José Sandi Maria Inés Molejon Marc Riemann Ezequiel Luis Calvo Gwen Lomberk Jean-Charles Dagorn Falk Weih Raul Urrutia Roland Michael Schmid Juan Lucio Iovanna

J Clin Invest 2012 Jun 8;122(6):2092-103. Epub 2012 May 8.

Centre de Recherche en Cancérologie de Marseille (CRCM), INSERM UMR 1068, CNRS UMR 7258, Aix-Marseille Université and Institut Paoli-Calmettes, Marseille, France.

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http://dx.doi.org/10.1172/JCI60144DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3366404PMC
June 2012

Sequence-specific recruitment of heterochromatin protein 1 via interaction with Krüppel-like factor 11, a human transcription factor involved in tumor suppression and metabolic diseases.

Authors:
Gwen Lomberk Angela J Mathison Adrienne Grzenda Seungmae Seo Cathrine J DeMars Sumera Rizvi Juliana Bonilla-Velez Ezequiel Calvo Martin E Fernandez-Zapico Juan Iovanna Navtej S Buttar Raul Urrutia

J Biol Chem 2012 Apr 8;287(16):13026-39. Epub 2012 Feb 8.

Department of Biochemistry and Molecular Biology, Laboratory of Epigenetics and Chromatin Dynamics, GIH Division, Mayo Clinic, Rochester, Minnesota 55905, USA.

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http://dx.doi.org/10.1074/jbc.M112.342634DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3339955PMC
April 2012

Krüppel-like factor 11 differentially couples to histone acetyltransferase and histone methyltransferase chromatin remodeling pathways to transcriptionally regulate dopamine D2 receptor in neuronal cells.

Authors:
Seungmae Seo Gwen Lomberk Angela Mathison Navtej Buttar Jewel Podratz Ezequiel Calvo Juan Iovanna Stephen Brimijoin Anthony Windebank Raul Urrutia

J Biol Chem 2012 Apr 28;287(16):12723-35. Epub 2012 Feb 28.

Mayo Graduate School, Mayo Clinic, Rochester, Minnesota 55905, USA.

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http://dx.doi.org/10.1074/jbc.M112.351395DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3339994PMC
April 2012

Detailed structural-functional analysis of the Krüppel-like factor 16 (KLF16) transcription factor reveals novel mechanisms for silencing Sp/KLF sites involved in metabolism and endocrinology.

Authors:
Gaurang S Daftary Gwen A Lomberk Navtej S Buttar Thomas W Allen Adrienne Grzenda Jinsan Zhang Ye Zheng Angela J Mathison Ravi P Gada Ezequiel Calvo Juan L Iovanna Daniel D Billadeau Franklyn G Prendergast Raul Urrutia

J Biol Chem 2012 Mar 27;287(10):7010-25. Epub 2011 Dec 27.

Department of Obstetrics and Gynecology, Mayo Clinic, Rochester, Minnesota 55905, USA.

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http://dx.doi.org/10.1074/jbc.M111.266007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3293586PMC
March 2012