Raul Urrutia

Raul Urrutia

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Raul Urrutia

Publications by authors named "Raul Urrutia"

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Modeling post-translational modifications and cancer-associated mutations that impact the heterochromatin protein 1α-importin α heterodimers.

Proteins 2019 Nov 14;87(11):904-916. Epub 2019 Jun 14.

Division of Research, Department of Surgery, Medical College of Wisconsin, Milwaukee, Wisconsin.

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http://dx.doi.org/10.1002/prot.25752DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6790107PMC
November 2019

Targeting the Stress-Induced Protein NUPR1 to Treat Pancreatic Adenocarcinoma.

Cells 2019 Nov 17;8(11). Epub 2019 Nov 17.

Centre de Recherche en Cancérologie de Marseille (CRCM), INSERM U1068, CNRS UMR 7258, Aix-Marseille Université, CEDEX, Marseille 13288, France.

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http://dx.doi.org/10.3390/cells8111453DOI Listing
November 2019

Genetic variants in DGAT1 cause diverse clinical presentations of malnutrition through a specific molecular mechanism.

Eur J Med Genet 2019 Nov 25:103817. Epub 2019 Nov 25.

Bioinformatics Research and Development Laboratory, Genomic Sciences and Precision Medicine Center, Medical College of Wisconsin, Milwaukee, WI, 53226, USA; Clinical and Translational Sciences Institute, Medical College of Wisconsin, Milwaukee, WI, 53226, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ejmg.2019.103817DOI Listing
November 2019

Molecular characterization of known and novel ACVR1 variants in phenotypes of aberrant ossification.

Am J Med Genet A 2019 Sep 26;179(9):1764-1777. Epub 2019 Jun 26.

Center for Individualized Medicine, Mayo Clinic, Rochester, Minnesota.

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http://dx.doi.org/10.1002/ajmg.a.61274DOI Listing
September 2019

ErbB3-binding protein 1 (EBP1) represses HNF4α-mediated transcription and insulin secretion in pancreatic β-cells.

J Biol Chem 2019 Sep 30;294(38):13983-13994. Epub 2019 Jul 30.

Section of Structural Biology, Hormel Institute, University of Minnesota, Austin, Minnesota 55912

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http://dx.doi.org/10.1074/jbc.RA119.009558DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6755798PMC
September 2019

Precision Medicine and Precision Public Health: Academic Education and Community Engagement.

Am J Prev Med 2019 Aug;57(2):286-289

Department of Surgery, Medical College of Wisconsin, Milwaukee, Wisconsin; Genomic Science and Precision Medicine Center, Medical College of Wisconsin, Milwaukee, Wisconsin.

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http://dx.doi.org/10.1016/j.amepre.2019.03.010DOI Listing
August 2019

Emerging epigenomic landscapes of pancreatic cancer in the era of precision medicine.

Nat Commun 2019 08 28;10(1):3875. Epub 2019 Aug 28.

Division of Research, Department of Surgery and the Genomic Sciences and Precision Medicine Center (GSPMC), Medical College of Wisconsin, Milwaukee, WI, USA.

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http://dx.doi.org/10.1038/s41467-019-11812-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6713756PMC
August 2019

Aurora kinase B-phosphorylated HP1α functions in chromosomal instability.

Cell Cycle 2019 Jun 26;18(12):1407-1421. Epub 2019 May 26.

b Genomics and Precision Medicine Center (GSPMC), Medical College of Wisconsin , Milwaukee , WI , USA.

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http://dx.doi.org/10.1080/15384101.2019.1618126DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6592258PMC
June 2019

Disruption of FOXP3-EZH2 Interaction Represents a Pathobiological Mechanism in Intestinal Inflammation.

Cell Mol Gastroenterol Hepatol 2019 14;7(1):55-71. Epub 2018 Sep 14.

Epigenetics and Chromatin Dynamics Laboratory, Division of Gastroenterology and Hepatology and Translational Epigenomic Program, Center for Individualized Medicine, Mayo Clinic, Rochester, Minnesota. Electronic address:

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http://dx.doi.org/10.1016/j.jcmgh.2018.08.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6260395PMC
April 2019

Inactivation of NUPR1 promotes cell death by coupling ER-stress responses with necrosis.

Sci Rep 2018 11 19;8(1):16999. Epub 2018 Nov 19.

Centre de Recherche en Cancérologie de Marseille (CRCM), INSERM U1068, CNRS UMR 7258, Aix-Marseille Université and Institut Paoli-Calmettes, Parc Scientifique et Technologique de Luminy, Marseille, France.

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http://dx.doi.org/10.1038/s41598-018-35020-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6242935PMC
November 2018

Mechanisms Underlying the Regulation of HP1γ by the NGF-PKA Signaling Pathway.

Sci Rep 2018 10 10;8(1):15077. Epub 2018 Oct 10.

Genomic Sciences and Precision Medicine Center (GSPMC), Medical College of Wisconsin, Milwaukee, WI, USA.

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http://dx.doi.org/10.1038/s41598-018-33475-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6180112PMC
October 2018

Effects of histone methyltransferase inhibition in endometriosis.

Biol Reprod 2018 08;99(2):293-307

Department of Basic Sciences-Microbiology Division, Ponce Health Sciences University, Ponce, Puerto Rico, USA.

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http://dx.doi.org/10.1093/biolre/ioy030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6373837PMC
August 2018

Assessing Human Genetic Variations in Glucose Transporter SLC2A10 and Their Role in Altering Structural and Functional Properties.

Front Genet 2018 25;9:276. Epub 2018 Jul 25.

Department of Health Science Research, Division of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN, United States.

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http://dx.doi.org/10.3389/fgene.2018.00276DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6068234PMC
July 2018

Intrinsically disordered chromatin protein NUPR1 binds to the C-terminal region of Polycomb RING1B.

Proc Natl Acad Sci U S A 2017 Aug 18;114(31):E6332-E6341. Epub 2017 Jul 18.

Instituto de Biología Molecular y Celular, Universidad Miguel Hernández, 03202 Elche, Alicante, Spain;

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http://dx.doi.org/10.1073/pnas.1619932114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5547589PMC
August 2017

Resolution of Cochlear Inflammation: Novel Target for Preventing or Ameliorating Drug-, Noise- and Age-related Hearing Loss.

Front Cell Neurosci 2017 7;11:192. Epub 2017 Jul 7.

Laboratory of Auditory Cell Biology, Department of Head and Neck Surgery, David Geffen School of Medicine, University of CaliforniaLos Angeles, Los Angeles, CA, United States.

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http://dx.doi.org/10.3389/fncel.2017.00192DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5500902PMC
July 2017

Elucidation of -mediated Noonan syndrome with cardiac hypertrophy.

JCI Insight 2017 03 9;2(5):e91225. Epub 2017 Mar 9.

Department of Molecular Pharmacology and Experimental Therapeutics and Windland Smith Rice Sudden Death Genomics Laboratory.

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http://dx.doi.org/10.1172/jci.insight.91225DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5333962PMC
March 2017

A novel frameshift deletion in in a patient with Kleefstra Syndrome results in decreased H3K9 dimethylation.

Mol Genet Genomic Med 2017 Mar 26;5(2):141-146. Epub 2017 Jan 26.

Center for Individualized MedicineMayo ClinicRochesterMinnesota55901; Department of Health Science ResearchMayo ClinicRochesterMinnesota55901; Department of Clinical GenomicsMayo ClinicRochesterMinnesota55901; Department of Laboratory Medicine and PathologyMayo ClinicRochesterMinnesota55901.

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http://doi.wiley.com/10.1002/mgg3.268
Publisher Site
http://dx.doi.org/10.1002/mgg3.268DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5370226PMC
March 2017

Novel Pathogenic Variant in TGFBR2 Confirmed by Molecular Modeling Is a Rare Cause of Loeys-Dietz Syndrome.

Case Rep Genet 2017 9;2017:7263780. Epub 2017 Jan 9.

Department of Clinical Genomics, Center for Individualized Medicine, Mayo Clinic, Jacksonville, FL, USA; Division of Medical Genetics, Department of Pediatrics, Stanford University, Stanford, CA, USA.

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http://dx.doi.org/10.1155/2017/7263780DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5253504PMC
January 2017

Gold Nanoparticle Reprograms Pancreatic Tumor Microenvironment and Inhibits Tumor Growth.

ACS Nano 2016 12 19;10(12):10636-10651. Epub 2016 Oct 19.

Institute of Next Generation Healthcare, Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, Mount Sinai Health System , New York, New York 10029, United States.

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http://dx.doi.org/10.1021/acsnano.6b02231DOI Listing
December 2016

Functional characterization of a GFAP variant of uncertain significance in an Alexander disease case within the setting of an individualized medicine clinic.

Clin Case Rep 2016 09 15;4(9):885-95. Epub 2016 Aug 15.

Center for Individualized Medicine Mayo Clinic Rochester Minnesota USA; Department of Biomedical Informatics Mayo Clinic Rochester Minnesota USA; Department of Clinical Genomics Mayo Clinic Rochester Minnesota USA.

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http://dx.doi.org/10.1002/ccr3.655DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5018595PMC
September 2016

Novel Roles and Mechanism for Krüppel-like Factor 16 (KLF16) Regulation of Neurite Outgrowth and Ephrin Receptor A5 (EphA5) Expression in Retinal Ganglion Cells.

J Biol Chem 2016 08 11;291(35):18084-95. Epub 2016 Jul 11.

From the Departments of Physiological Optics and Vision Science and Biology and Biochemistry, University of Houston, Houston, Texas 77204,

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http://dx.doi.org/10.1074/jbc.M116.732339DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5000058PMC
August 2016

"The molecule's the thing:" the promise of molecular modeling and dynamic simulations in aiding the prioritization and interpretation of genomic testing results.

F1000Res 2016 27;5:766. Epub 2016 Apr 27.

Center for Individualized Medicine, Mayo Clinic, Rochester, MN, 55905, USA; Laboratory of Epigenetics and Chromatin Dynamics, Epigenomics Translational Program, Gastroenterology Research Unit, Departments of Biochemistry and Molecular Biology, Biophysics, and Medicine, Mayo Clinic, Rochester, MN, 55905, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4920209PMC
http://dx.doi.org/10.12688/f1000research.8600.3DOI Listing
August 2016

Pancreatitis promotes oncogenic Kras(G12D)-induced pancreatic transformation through activation of Nupr1.

Mol Cell Oncol 2014 28;1(1):e29913. Epub 2014 Jul 28.

Centre de Recherche en Cancérologie de Marseille (CRCM); Aix-Marseille Université and Institut Paoli-Calmettes; Parc Scientifique et Technologique de Luminy; Marseille, France.

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http://dx.doi.org/10.4161/mco.29913DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905183PMC
June 2016

The promise of epigenomic therapeutics in pancreatic cancer.

Epigenomics 2016 06 23;8(6):831-42. Epub 2016 Jun 23.

Laboratory of Epigenetics & Chromatin Dynamics, Gastroenterology Research Unit, Departments of Biochemistry & Molecular Biology, Biophysics, & Medicine, Mayo Clinic, Rochester, MN, USA.

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http://dx.doi.org/10.2217/epi-2015-0016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5066125PMC
June 2016

REG3β Plays a Key Role in IL17RA Protumoral Effect-Response.

Cancer Res 2016 04 18;76(7):2051. Epub 2016 Mar 18.

Centre de Recherche en Cancérologie de Marseille (CRCM), INSERM U1068, CNRS UMR 7258, Aix-Marseille Université and Institut Paoli-Calmettes, Parc Scientifique et Technologique de Luminy, Marseille, France.

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http://dx.doi.org/10.1158/0008-5472.CAN-15-3355DOI Listing
April 2016

Evidence supporting a critical contribution of intrinsically disordered regions to the biochemical behavior of full-length human HP1γ.

J Mol Model 2016 Jan 17;22(1):12. Epub 2015 Dec 17.

Laboratory of Epigenetics and Chromatin Dynamics, Gastroenterology Research Unit, Department of Biochemistry and Molecular Biology, Mayo Clinic, 200 First Street SW, Guggenheim 10, Rochester, MN, 55905, USA.

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http://dx.doi.org/10.1007/s00894-015-2874-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4683166PMC
January 2016

Functional Characterization of Nupr1L, A Novel p53-Regulated Isoform of the High-Mobility Group (HMG)-Related Protumoral Protein Nupr1.

J Cell Physiol 2015 Dec;230(12):2936-50

Centre de Recherche en Cancérologie de Marseille (CRCM), INSERM U1068, CNRS UMR 7258, Aix-Marseille Université and Institut Paoli-Calmettes, Parc Scientifique et Technologique de Luminy, Marseille, France.

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http://dx.doi.org/10.1002/jcp.25022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4778741PMC
December 2015

Biology and pathobiology of lipid droplets and their potential role in the protection of the organ of Corti.

Hear Res 2015 Dec 15;330(Pt A):26-38. Epub 2015 May 15.

Laboratory of Auditory Cell Biology, Department of Head & Neck Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA. Electronic address:

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http://dx.doi.org/10.1016/j.heares.2015.04.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5391798PMC
December 2015

Krüppel-like factor KLF10 deficiency predisposes to colitis through colonic macrophage dysregulation.

Am J Physiol Gastrointest Liver Physiol 2015 Dec 15;309(11):G900-9. Epub 2015 Oct 15.

Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota; and.

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http://dx.doi.org/10.1152/ajpgi.00309.2015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4669350PMC
December 2015

IL17 Functions through the Novel REG3β-JAK2-STAT3 Inflammatory Pathway to Promote the Transition from Chronic Pancreatitis to Pancreatic Cancer.

Cancer Res 2015 Nov 24;75(22):4852-62. Epub 2015 Sep 24.

Centre de Recherche en Cancérologie de Marseille (CRCM), INSERM U1068, CNRS UMR 7258, Aix-Marseille Université and Institut Paoli-Calmettes, Parc Scientifique et Technologique de Luminy, Marseille, France.

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http://dx.doi.org/10.1158/0008-5472.CAN-15-0896DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4651828PMC
November 2015

Pivotal Role of the Chromatin Protein Nupr1 in Kras-Induced Senescence and Transformation.

Sci Rep 2015 Nov 30;5:17549. Epub 2015 Nov 30.

Centre de Recherche en Cancérologie de Marseille (CRCM), INSERM U1068, CNRS UMR 7258, Aix-Marseille Université and Institut Paoli-Calmettes, Parc Scientifique et Technologique de Luminy, Marseille, France.

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http://dx.doi.org/10.1038/srep17549DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4663475PMC
November 2015

Phenotypic Characterization of Mice Carrying Homozygous Deletion of KLF11, a Gene in Which Mutations Cause Human Neonatal and MODY VII Diabetes.

Endocrinology 2015 Oct 6;156(10):3581-95. Epub 2015 Aug 6.

Laboratory of Epigenetics and Chromatin Dynamics (A.M., A.S., W.A.F., N.B., G.L., R.U.), Gastroenterology Research Unit, Departments of Biochemistry and Molecular Biology, Biophysics, Medicine, Epigenomics Translation Program Center for Individualized Medicine, Mayo Clinic, Rochester, Minnesota 55905; Metabolic Diseases and Aging Laboratory (C.E.), Institut Pasteur Montevideo, Montevideo 11400, Uruguay; Department of Anesthesia and Robert and Arlene Kogod Center on Aging (C.E., T.W., E.N.C.), Mayo Clinic, Rochester, Minnesota 55905; Endocrinology and Nephrology (E.C.), Centre Hospitalier Universitaire de Québec Research Center and Laval University, Québec, Québec, G1V 4G2, Canada; Lieber Institute for Brain Development (S.S.), Baltimore, Maryland 21205; and Centre de Recherche en Cancérologie de Marseille (J.I.), INSERM U1068, Centre Nationale de la Recherche Scientifique Unité Mixte de Recherche 7258, Aix-Marseille Université and Institut Paoli-Calmettes, Parc Scientifique et Technologique de Luminy, Marseille, 13288, France.

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http://dx.doi.org/10.1210/en.2015-1145DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4588811PMC
October 2015

The Triple-Code Model for Pancreatic Cancer: Cross Talk Among Genetics, Epigenetics, and Nuclear Structure.

Surg Clin North Am 2015 Oct 23;95(5):935-52. Epub 2015 Jul 23.

Laboratory of Epigenetics and Chromatin Dynamics, Gastroenterology Research Unit, Department of Biochemistry and Molecular Biology, Mayo Clinic, Guggenheim 10-42C, Rochester, MN 55905, USA; Laboratory of Epigenetics and Chromatin Dynamics, Gastroenterology Research Unit, Department of Biophysics, Mayo Clinic, Guggenheim 10-42C, Rochester, MN 55905, USA; Laboratory of Epigenetics and Chromatin Dynamics, Gastroenterology Research Unit, Department of Medicine, Mayo Clinic, Guggenheim 10-42C, Rochester, MN 55905, USA. Electronic address:

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http://dx.doi.org/10.1016/j.suc.2015.05.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4556141PMC
October 2015

Development and characterization of human-induced pluripotent stem cell-derived cholangiocytes.

Lab Invest 2015 Jun 13;95(6):684-96. Epub 2015 Apr 13.

1] Division of Gastroenterology and Hepatology, Mayo Clinic and Foundation, Rochester, MN, USA [2] Gastroenterology Research Unit, Mayo Clinic and Foundation, Rochester, MN, USA [3] Center for Cell Signaling in Gastroenterology, Mayo Clinic and Foundation, Rochester, MN, USA.

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http://dx.doi.org/10.1038/labinvest.2015.51DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4447567PMC
June 2015

Evidence revealing deregulation of the KLF11-MAO A pathway in association with chronic stress and depressive disorders.

Neuropsychopharmacology 2015 May 15;40(6):1373-82. Epub 2014 Dec 15.

1] Department of Psychiatry and Human Behavior, Jackson, MS, USA [2] Program in Neuroscience, Jackson, MS, USA [3] Department of Pathology, University of Mississippi Medical Center, Jackson, MS, USA.

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http://dx.doi.org/10.1038/npp.2014.321DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4397395PMC
May 2015

The Aurora A-HP1γ pathway regulates gene expression and mitosis in cells from the sperm lineage.

BMC Dev Biol 2015 May 29;15:23. Epub 2015 May 29.

Department of Medicine, Mayo Clinic, Laboratory of Epigenetics and Chromatin Dynamics, Gastroenterology Research Unit, Guggenheim 10, 200 First Street SW, Rochester, MN, 55905, USA.

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http://dx.doi.org/10.1186/s12861-015-0073-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4448908PMC
May 2015

Membrane-to-Nucleus Signals and Epigenetic Mechanisms for Myofibroblastic Activation and Desmoplastic Stroma: Potential Therapeutic Targets for Liver Metastasis?

Mol Cancer Res 2015 Apr 29;13(4):604-12. Epub 2014 Dec 29.

GI Research Unit, Division of Gastroenterology and Hepatology, Epigenomics Translational Program, Center for Individualized Medicine, Mayo Clinic, Rochester, Minnesota.

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http://dx.doi.org/10.1158/1541-7786.MCR-14-0542DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4398610PMC
April 2015

Gestational diabetes mellitus impairs fetal endothelial cell functions through a mechanism involving microRNA-101 and histone methyltransferase enhancer of zester homolog-2.

Arterioscler Thromb Vasc Biol 2015 Mar 22;35(3):664-74. Epub 2015 Jan 22.

From the Bristol Heart Institute, School of Clinical Sciences, University of Bristol, Bristol, United Kingdom (I.F., B.D., A.V., T.M., S.S., G.S.-N., G.M., L.H., C.E.); Laboratory of Vascular Biology, Department of Biomedical Science (I.F., A.V., M.P., G.P.) and Department of Obstetrics and Gynecology Unit (G.C., S.D.), University of Sassari, Sassari, Italy; Laboratory of Epigenetics and Chromatin Dynamics, Mayo Clinic, Rochester, MN (R.U.); and National Heart and Lung Institute, Imperial College London, London, United Kingdom (C.E.).

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http://dx.doi.org/10.1161/ATVBAHA.114.304730DOI Listing
March 2015

A novel role for KLF14 in T regulatory cell differentiation.

Cell Mol Gastroenterol Hepatol 2015 Mar;1(2):188-202.e4

Epigenetics and Chromatin Dynamics Laboratory, Division of Gastroenterology and Hepatology and Translational Epigenomic Program, Center for Individualized Medicine (CIM), Mayo Clinic Rochester.

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http://dx.doi.org/10.1016/j.jcmgh.2014.12.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4349492PMC
March 2015

EZH2 modulates angiogenesis in vitro and in a mouse model of limb ischemia.

Mol Ther 2015 Jan 5;23(1):32-42. Epub 2014 Sep 5.

1] Bristol Heart Institute, School of Clinical Sciences, University of Bristol, England, UK [2] National Heart and Lung Institute, Hammersmith Campus, Imperial College of London, London, England, UK.

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http://dx.doi.org/10.1038/mt.2014.163DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4426795PMC
January 2015

Krüppel-like factor 9 promotes hepatic cytochrome P450 2D6 expression during pregnancy in CYP2D6-humanized mice.

Mol Pharmacol 2014 Dec 12;86(6):727-35. Epub 2014 Sep 12.

Department of Pharmacy Practice (K.H.K., H.J.), Department of Biopharmaceutical Sciences (X.P., H.J.), College of Pharmacy, and Department of Pediatrics (W.Z.) and Department of Microbiology and Immunology (A.M.), College of Medicine, University of Illinois at Chicago, Chicago, Illinois; and Laboratory of Epigenetics and Chromatin Dynamics, and Departments of Biology and Molecular Biology, Epigenomics Translational Program, Mayo Clinic Center for Individualized Medicine, Mayo Clinic, Rochester, Minnesota (R.U.)

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http://dx.doi.org/10.1124/mol.114.093666DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4244597PMC
December 2014

Deleted in Breast Cancer 1 regulates cellular senescence during obesity.

Aging Cell 2014 Oct 3;13(5):951-3. Epub 2014 Jul 3.

Department of Anesthesia, Mayo Clinic, Rochester, MN, USA; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA; Institut Pasteur Montevideo, Montevideo, Uruguay.

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http://doi.wiley.com/10.1111/acel.12235
Publisher Site
http://dx.doi.org/10.1111/acel.12235DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4172532PMC
October 2014

Differential coupling of KLF10 to Sin3-HDAC and PCAF regulates the inducibility of the FOXP3 gene.

Am J Physiol Regul Integr Comp Physiol 2014 Sep 18;307(6):R608-20. Epub 2014 Jun 18.

Epigenetics and Chromatin Dynamics Laboratory, Mayo Clinic, Rochester, Minnesota; Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota; Translational Epigenomic Program, Center for Individualized Medicine, Mayo Clinic, Rochester, Minnesota; and

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http://dx.doi.org/10.1152/ajpregu.00085.2014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4166759PMC
September 2014

Membrane-to-nucleus signaling links insulin-like growth factor-1- and stem cell factor-activated pathways.

PLoS One 2013 7;8(10):e76822. Epub 2013 Oct 7.

Enteric Neuroscience Program, Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, Minnesota, United States of America ; Gastroenterology Research Unit, Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0076822PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3792098PMC
August 2014

Evidence supporting the existence of a NUPR1-like family of helix-loop-helix chromatin proteins related to, yet distinct from, AT hook-containing HMG proteins.

J Mol Model 2014 Aug 24;20(8):2357. Epub 2014 Jul 24.

Laboratory of Epigenetics and Chromatin Dynamics, Departments of Biochemistry and Molecular Biology, Biophysics, and Medicine, Epigenomics Translational Program, Center for Individualized Medicine., Mayo Clinic, 200 First Street SW, Guggenheim 10, Rochester, MN, 55905, USA,

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http://dx.doi.org/10.1007/s00894-014-2357-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4139591PMC
August 2014

Acetaminophen and NAPQI are toxic to auditory cells via oxidative and endoplasmic reticulum stress-dependent pathways.

Hear Res 2014 Jul 30;313:26-37. Epub 2014 Apr 30.

Department of Head & Neck Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA. Electronic address:

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http://dx.doi.org/10.1016/j.heares.2014.04.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4084927PMC
July 2014

Genetic inactivation of Nupr1 acts as a dominant suppressor event in a two-hit model of pancreatic carcinogenesis.

Gut 2014 Jun 11;63(6):984-95. Epub 2013 Sep 11.

Centre de Recherche en Carcérologie de Marseille (CRCM), INSERM UMR 1068, CNRS UMR 7258, Aix-Marseille University and Institut Paoli-Calmettes, Parc Scientifique et Technologique de Luminy, , Marseille, France.

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http://gut.bmj.com/cgi/doi/10.1136/gutjnl-2013-305221
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June 2014

Role for Krüppel-like transcription factor 11 in mesenchymal cell function and fibrosis.

PLoS One 2013 17;8(9):e75311. Epub 2013 Sep 17.

Laboratory of Epigenetics and Chromatin Dynamics, Mayo Clinic, Rochester, Minnesota, United States of America ; Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, United States of America.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3775729PMC
June 2014

Inflammation-induced NFATc1-STAT3 transcription complex promotes pancreatic cancer initiation by KrasG12D.

Cancer Discov 2014 Jun 2;4(6):688-701. Epub 2014 Apr 2.

Authors' Affiliations:Signaling and Transcription Laboratory, Department of Gastroenterology, Philipps University, Marburg; Department of Gastroenterology and Gastrointestinal Oncology, University Medical Center Göttingen, Göttingen; II. Medizinische Klinik, Klinikum rechts der Isar, Technische Universität; Institute of Pathology, Helmholtz Zentrum, Munich; Theodor Boveri Institute, University of Würzburg, Würzburg; Institute for Genetics, Justus-Liebig-University, Giessen, Germany; Schulze Center for Novel Therapeutics, Division of Oncology Research; Divisions of Anatomic Pathology and Biostatistics, College of Medicine; Laboratory of Epigenetics and Chromatin Dynamics, Department of Medicine, Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota; Barrow Brain Tumor Research Center, St. Joseph's Hospital and Medical Center, Phoenix, Arizona; and Cold Spring Harbor Laboratory, Cold Spring Harbor, New York

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http://dx.doi.org/10.1158/2159-8290.CD-13-0593DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4069603PMC
June 2014

New role for Kruppel-like factor 14 as a transcriptional activator involved in the generation of signaling lipids.

J Biol Chem 2014 May 23;289(22):15798-809. Epub 2014 Apr 23.

From the Gastroenterology Research Unit, Departments of Biochemistry and Molecular Biology, Physiology and Biophysics, and Medicine and

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http://dx.doi.org/10.1074/jbc.M113.544346DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4140934PMC
May 2014

Diabetes-causing gene, kruppel-like factor 11, modulates the antinociceptive response of chronic ethanol intake.

Alcohol Clin Exp Res 2014 Feb 15;38(2):401-8. Epub 2014 Jan 15.

Department of Psychiatry and Human Behavior , University of Mississippi Medical Center, Jackson, Mississippi.

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http://dx.doi.org/10.1111/acer.12258DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5567722PMC
February 2014

A novel role of the Sp/KLF transcription factor KLF11 in arresting progression of endometriosis.

PLoS One 2013 28;8(3):e60165. Epub 2013 Mar 28.

Laboratory of Translational Epigenetics in Reproduction, Department of Obstetrics and Gynecology, Mayo Clinic, Rochester, MN, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3610699PMC
September 2013

Functional impact of Aurora A-mediated phosphorylation of HP1γ at serine 83 during cell cycle progression.

Epigenetics Chromatin 2013 Jul 5;6(1):21. Epub 2013 Jul 5.

Laboratory of Epigenetics and Chromatin Dynamics, GIH Division, Department of Medicine, Biochemistry and Molecular Biology, Guggenheim 10, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.

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http://dx.doi.org/10.1186/1756-8935-6-21DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3707784PMC
July 2013

Krüppel-like factor 11 regulates the expression of metabolic genes via an evolutionarily conserved protein interaction domain functionally disrupted in maturity onset diabetes of the young.

J Biol Chem 2013 Jun 15;288(24):17745-58. Epub 2013 Apr 15.

Laboratory of Epigenetics and Chromatin Dynamics, Epigenomics Translational Program, Mayo Clinic Center for Individualized Medicine, Division of Gastroenterology and Hepatology, and Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota 55905, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3682574PMC
June 2013

Epigenetics: a promising paradigm for better understanding and managing pain.

J Pain 2013 Jun 19;14(6):549-57. Epub 2013 Apr 19.

Laboratory of Epigenetics and Chromatin Dynamics, Translational Epigenomic Program, Center for Individualized Medicine, GIH Division, Department of Medicine, Physiology, Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota, USA.

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http://dx.doi.org/10.1016/j.jpain.2013.01.772DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3672350PMC
June 2013

Cross-species analysis of nicotine-induced proteomic alterations in pancreatic cells.

Proteomics 2013 May;13(9):1499-1512

Department of Pathology, Children's Hospital Boston and Harvard Medical School, Boston, MA Proteomics Center at Children's Hospital Boston, Boston, MA.

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http://dx.doi.org/10.1002/pmic.201200492DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4036444PMC
May 2013

Mechanistic insights into self-reinforcing processes driving abnormal histogenesis during the development of pancreatic cancer.

Am J Pathol 2013 Apr 31;182(4):1078-86. Epub 2013 Jan 31.

Cancer Research Center of Marseille, Inserm U1068, CNRS, UMR7258, Institute Paoli-Calmettes, Aix-Marseille University, Marseille, France.

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http://dx.doi.org/10.1016/j.ajpath.2012.12.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3969507PMC
April 2013

KLF11 mediates PPARγ cerebrovascular protection in ischaemic stroke.

Brain 2013 Apr 12;136(Pt 4):1274-87. Epub 2013 Feb 12.

Cardiovascular Centre, Department of Internal Medicine, University of Michigan Medical Centre, NCRC Bld 26, Rm 361S, 2800 Plymouth Rd, Ann Arbor, MI 48109, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3613710PMC
April 2013

Krüppel-like factor-11, a transcription factor involved in diabetes mellitus, suppresses endothelial cell activation via the nuclear factor-κB signaling pathway.

Arterioscler Thromb Vasc Biol 2012 Dec 4;32(12):2981-8. Epub 2012 Oct 4.

Cardiovascular Center, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, MI 48109, USA.

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http://dx.doi.org/10.1161/ATVBAHA.112.300349DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3556387PMC
December 2012

Nuclear protein 1 promotes pancreatic cancer development and protects cells from stress by inhibiting apoptosis.

J Clin Invest 2012 Jun 8;122(6):2092-103. Epub 2012 May 8.

Centre de Recherche en Cancérologie de Marseille (CRCM), INSERM UMR 1068, CNRS UMR 7258, Aix-Marseille Université and Institut Paoli-Calmettes, Marseille, France.

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http://dx.doi.org/10.1172/JCI60144DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3366404PMC
June 2012