Raul D Santos

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Screening and management of familial hypercholesterolemia.

Authors:
Raul D Santos

Curr Opin Cardiol 2019 Sep;34(5):526-530

Lipid Clinic Heart Institute (InCor), University of Sao Paulo Medical School Hospital.

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http://dx.doi.org/10.1097/HCO.0000000000000660DOI Listing
September 2019

Baseline LDL-C levels and risk of cardiovascular events: is there any room for questions?

Int J Cardiol 2019 Jul 29;286:166-167. Epub 2019 Mar 29.

Lipid Clinic Heart Institute (InCor)-University of Sao Paulo Medical School Hospital, Sao Paulo, Brazil; Hospital Israelita Albert Einstein, Sao Paulo, Brazil.

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http://dx.doi.org/10.1016/j.ijcard.2019.03.058DOI Listing
July 2019

Real-World Outcomes with Lomitapide Use in Paediatric Patients with Homozygous Familial Hypercholesterolaemia.

Adv Ther 2019 Jul 17;36(7):1786-1811. Epub 2019 May 17.

Lipid Clinic, Heart Institute (InCor), University of Sao Paulo and Hospital Israelita Albert Einstein, São Paulo, Brazil.

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http://link.springer.com/10.1007/s12325-019-00985-8
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http://dx.doi.org/10.1007/s12325-019-00985-8DOI Listing
July 2019

Impact of improved low-density lipoprotein cholesterol assessment on guideline classification in the modern treatment era-Results from a racially diverse Brazilian cross-sectional study.

J Clin Lipidol 2019 Jul 9. Epub 2019 Jul 9.

Ciccarone Center for the Prevention of Cardiovascular Disease, Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA. Electronic address:

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http://dx.doi.org/10.1016/j.jacl.2019.07.002DOI Listing
July 2019

Epicardial adipose tissue thickness and type 2 diabetes risk according to the FINDRISC modified for Latin America.

Clin Investig Arterioscler 2019 Jan - Feb;31(1):15-22. Epub 2018 Aug 27.

Division of Endocrinology, Department of Medicine, University of Miami Miller School of Medicine, Miami, USA.

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http://dx.doi.org/10.1016/j.arteri.2018.06.002DOI Listing
June 2019

The selective peroxisome proliferator-activated receptor alpha modulator (SPPARMα) paradigm: conceptual framework and therapeutic potential : A consensus statement from the International Atherosclerosis Society (IAS) and the Residual Risk Reduction Initiative (R3i) Foundation.

Cardiovasc Diabetol 2019 Jun 4;18(1):71. Epub 2019 Jun 4.

Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1186/s12933-019-0864-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6549355PMC
June 2019

Inadequate control of atherosclerotic cardiovascular disease risk factors in Europe: EUROASPIRE repeats itself.

Authors:
Raul D Santos

Eur J Prev Cardiol 2019 May 20;26(8):820-823. Epub 2019 Feb 20.

1 Lipid Clinic Heart Institute (InCor), University of Sao Paulo Medical School Hospital, Brazil.

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http://dx.doi.org/10.1177/2047487319831476DOI Listing
May 2019

HDL-cholesterol level and mortality occurrence in the elderly: is the good cholesterol always good?

J Clin Endocrinol Metab 2019 May 16. Epub 2019 May 16.

Lipid Clinic Heart Institute (InCor) University of Sao Paulo Medical School Hospital and Hospital Israelita Albert Einstein, Sao Paulo, Brazil.

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http://dx.doi.org/10.1210/jc.2019-00845DOI Listing
May 2019

Low-density lipoprotein cholesterol goal achievement in patients with familial hypercholesterolemia in countries outside Western Europe: The International ChoLesterol management Practice Study.

J Clin Lipidol 2019 May 14. Epub 2019 May 14.

Lipid Clinic, Heart Institute (InCor), University of Sao Paulo Medical School Hospital and Hospital Israelita Albert Einstein, Sao Paulo, Brazil.

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http://dx.doi.org/10.1016/j.jacl.2019.05.004DOI Listing
May 2019

Residual vascular risk in diabetes - Will the SPPARM alpha concept hold the key?

Diabetes Metab Syndr 2019 Jul - Aug;13(4):2723-2725. Epub 2019 May 30.

Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1016/j.dsx.2019.05.034DOI Listing
May 2019

Safety of statin treatment in children with familial hypercholesterolemia: Filling the gaps.

J Clin Lipidol 2018 Jan - Feb;12(1):12-15. Epub 2017 Dec 7.

Lipid Clinic Heart Institute (InCor), University of São Paulo Medical School Hospital, São Paulo, Brazil; Hospital Israelita Albert Einstein, São Paulo, Brazil. Electronic address:

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http://dx.doi.org/10.1016/j.jacl.2017.11.007DOI Listing
April 2019

Does nonalcoholic fatty liver disease cause cardiovascular disease? Current knowledge and gaps.

Atherosclerosis 2019 Mar 30;282:110-120. Epub 2019 Jan 30.

Department of Molecular and Clinical Medicine Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; Clinical Nutrition Unit, Department of Medical and Surgical Sciences, Magna Graecia University, Catanzaro, Italy.

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http://dx.doi.org/10.1016/j.atherosclerosis.2019.01.029DOI Listing
March 2019

Case report: The efficacy and safety of lomitapide in a homozygous familial hypercholesterolemic child.

J Clin Lipidol 2019 May - Jun;13(3):397-401. Epub 2019 Mar 11.

Lipid Clinic Heart Institute (InCor), University of Sao Paulo Medical School Hospital, Sao Paulo, Brazil; Hospital Israelita Albert Einstein, Sao Paulo, Brazil. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S19332874193004
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http://dx.doi.org/10.1016/j.jacl.2019.03.001DOI Listing
March 2019

Simon Broome confirms that the IAS definition of severe familial hypercholesterolemia predicts coronary mortality in patients with FH.

Atherosclerosis 2019 Feb 22;281:145-147. Epub 2018 Dec 22.

School of Medicine, Faculty of Health and Medical Sciences, University of Western Australia, Perth, Western Australia, Australia; Lipid Disorders Clinic, Cardiometabolic Service, Department of Cardiology, Royal Perth Hospital, Perth, Australia.

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http://dx.doi.org/10.1016/j.atherosclerosis.2018.12.013DOI Listing
February 2019

Distinct phospholipid and sphingolipid species are linked to altered HDL function in apolipoprotein A-I deficiency.

J Clin Lipidol 2019 May - Jun;13(3):468-480.e8. Epub 2019 Feb 25.

UMR-ICAN 1166, National Institute for Health and Medical Research (INSERM), Sorbonne University, Paris, France. Electronic address:

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http://dx.doi.org/10.1016/j.jacl.2019.02.004DOI Listing
February 2019

Safety and efficacy of mipomersen in patients with heterozygous familial hypercholesterolemia.

Atherosclerosis 2019 Jan 10;280:109-117. Epub 2018 Nov 10.

Sections of Cardiology and Cardiovascular Research, Baylor College of Medicine, Houston, TX, USA.

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http://dx.doi.org/10.1016/j.atherosclerosis.2018.11.017DOI Listing
January 2019

Comparative aspects of the care of familial hypercholesterolemia in the "Ten Countries Study".

J Clin Lipidol 2019 Mar - Apr;13(2):287-300. Epub 2019 Jan 25.

School of Medicine, Faculty of Health and Medical Sciences, University of Western Australia, Perth, Western Australia, Australia; Department of Cardiology, Lipid Disorders Clinic, Cardiometabolic Services, Royal Perth Hospital, Perth, Western Australia, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.jacl.2019.01.009DOI Listing
January 2019

Mendelian randomization causally link lipoproteins to systemic atherosclerosis and help design clinical trials for the future of lipidology.

Curr Opin Lipidol 2018 12;29(6):482-483

Lipid Clinic Heart Institute (InCor), University of Sao Paulo Medical School Hospital.

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http://dx.doi.org/10.1097/MOL.0000000000000557DOI Listing
December 2018

Coronary Artery Calcium and Cardiovascular Events in Patients With Familial Hypercholesterolemia Receiving Standard Lipid-Lowering Therapy.

JACC Cardiovasc Imaging 2018 Nov 8. Epub 2018 Nov 8.

Heart Institute (InCor), University of São Paulo Medical School Hospital, São Paulo, Brazil; Hospital Israelita Albert Einstein, São Paulo, Brazil. Electronic address:

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http://imaging.onlinejacc.org/content/early/recent
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https://linkinghub.elsevier.com/retrieve/pii/S1936878X183093
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http://dx.doi.org/10.1016/j.jcmg.2018.09.019DOI Listing
November 2018

Predictors of Family Enrollment in a Genetic Cascade Screening Program for Familial Hypercholesterolemia.

Arq Bras Cardiol 2018 Oct 23;111(4):578-584. Epub 2018 Aug 23.

Laboratório de Genética e Cardiologia Molecular do Instituto do Coração (InCor) da Faculdade de Medicina da Universidade de São Paulo, São Paulo, SP - Brazil.

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http://dx.doi.org/10.5935/abc.20180156DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6199512PMC
October 2018

Overview of the current status of familial hypercholesterolaemia care in over 60 countries - The EAS Familial Hypercholesterolaemia Studies Collaboration (FHSC).

Atherosclerosis 2018 10;277:234-255

Imperial Centre for Cardiovascular Disease Prevention (ICCP), Department of Primary Care and Public Health, School of Public Health, Imperial College London, London, United Kingdom.

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http://dx.doi.org/10.1016/j.atherosclerosis.2018.08.051DOI Listing
October 2018

Familial hypercholesterolemia prevalence in an admixed racial society: Sex and race matter. The ELSA-Brasil.

Atherosclerosis 2018 10;277:273-277

Center for Clinical and Epidemiological Research, University Hospital, University of Sao Paulo, 2565 Prof. Lineu Prestes Avenue, Sao Paulo, 05508-000, Brazil. Electronic address:

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http://dx.doi.org/10.1016/j.atherosclerosis.2018.08.021DOI Listing
October 2018

Health related quality of life in individuals at high risk for familial hypercholesterolemia undergoing genetic cascade screening in Brazil.

Atherosclerosis 2018 10;277:464-469

Heart Institute (InCor) University of Sao Paulo Medical School Hospital, Sao Paulo, Brazil; Hospital Israelita Albert Einstein, Sao Paulo, Brazil. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00219150183027
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http://dx.doi.org/10.1016/j.atherosclerosis.2018.05.036DOI Listing
October 2018

Heterozygous familial hypercholesterolaemia in specialist centres in South Africa, Australia and Brazil: Importance of early detection and lifestyle advice.

Atherosclerosis 2018 10;277:470-476

School of Medicine, Faculty of Health and Medical Sciences, University of Western Australia, Perth, Western Australia, Australia; Lipid Disorders Clinic, Cardiometabolic Services, Department of Cardiology, Royal Perth Hospital, Perth, Western Australia, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.atherosclerosis.2018.06.822DOI Listing
October 2018

Effects of medication, treatment, and behavioral beliefs on intentions to take medication in patients with familial hypercholesterolemia.

Atherosclerosis 2018 10;277:493-501

School of Medicine, Faculty of Health and Medical Sciences, University of Western Australia, Perth, Western Australia, Australia; Lipid Disorders Clinic, Cardiometabolic Service, Department of Cardiology, Royal Perth Hospital, Perth, Australia.

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http://dx.doi.org/10.1016/j.atherosclerosis.2018.06.010DOI Listing
October 2018

Beware of early drug intolerance in secondary prevention of cardiovascular disease.

Authors:
Raul D Santos

Eur Heart J Cardiovasc Pharmacother 2018 10;4(4):202-204

Lipid Clinic Heart Institute (InCor), University of Sao Paulo Medical School Hospital, Sao Paulo, Brazil.

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https://academic.oup.com/ehjcvp/article/4/4/202/5059516
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http://dx.doi.org/10.1093/ehjcvp/pvy023DOI Listing
October 2018

Self-initiated physical activity is associated with high sensitivity C-reactive protein: A longitudinal study in 5,030 adults.

Atherosclerosis 2018 06 8;273:131-135. Epub 2018 Feb 8.

Hospital Israelita Albert Einstein, Sao Paulo, Brazil; Faculdade Israelita de Ciências da Saúde Albert Einstein, Sao Paulo, Brazil.

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https://linkinghub.elsevier.com/retrieve/pii/S00219150183007
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http://dx.doi.org/10.1016/j.atherosclerosis.2018.02.011DOI Listing
June 2018

Statin Eligibility in Primary Prevention: From a Risk-Based Strategy to a Personalized Approach Based on the Predicted Benefit.

Am J Cardiol 2018 06 1;121(11):1315-1320. Epub 2018 Mar 1.

Preventive Medicine Center, Hospital Israelita Albert Einstein, São Paulo, São Paulo, Brazil; Division of Internal Medicine, University Hospital, University of São Paulo, São Paulo, São Paulo, Brazil.

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http://dx.doi.org/10.1016/j.amjcard.2018.02.011DOI Listing
June 2018

Cholesterol and inflammation: The lesser the better in atherothrombosis.

Eur J Prev Cardiol 2018 06 14;25(9):944-947. Epub 2018 May 14.

1 Lipid Clinic Heart Institute (InCor), University of Sao Paulo Medical School Hospital, Brazil.

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http://dx.doi.org/10.1177/2047487318772936DOI Listing
June 2018

Estimated costs of hospitalization due to coronary artery disease attributable to familial hypercholesterolemia in the Brazilian public health system.

Arch Endocrinol Metab 2018 Jun 17;62(3):303-308. Epub 2018 May 17.

Departamento de Medicina Interna, Universidade do Estado do Rio de Janeiro (UERJ); Instituto de Avaliação de Tecnologia em Saúde (IATS), Rio de Janeiro, RJ, Brasil.

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http://dx.doi.org/10.20945/2359-3997000000030DOI Listing
June 2018

Association between high-density lipoprotein subfractions and low-grade inflammation, insulin resistance, and metabolic syndrome components: The ELSA-Brasil study.

J Clin Lipidol 2018 Sep - Oct;12(5):1290-1297.e1. Epub 2018 May 26.

Center for Clinical and Epidemiological Research, University Hospital, University of São Paulo, São Paulo, Brazil. Electronic address:

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http://dx.doi.org/10.1016/j.jacl.2018.05.003DOI Listing
May 2018

Expression of LDLRs (Low-Density Lipoprotein Receptors), Dyslipidemia Severity, and Response to PCSK9 (Proprotein Convertase Subtilisin Kexin Type 9) Inhibition in Homozygous Familial Hypercholesterolemia: Connecting the Dots.

Authors:
Raul D Santos

Arterioscler Thromb Vasc Biol 2018 03;38(3):481-483

From the Lipid Clinic Heart Institute (InCor), University of Sao Paulo Medical School Hospital, Brazil; and Preventive Medicine Centre and Cardiology Program, Hospital Israelita Albert Einstein, Sao Paulo, Brazil.

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http://dx.doi.org/10.1161/ATVBAHA.117.310675DOI Listing
March 2018

Prevalence, management, and outcomes of familial hypercholesterolemia in patients with acute coronary syndromes in the Arabian Gulf.

J Clin Lipidol 2018 May - Jun;12(3):685-692.e2. Epub 2018 Feb 14.

Department of Medicine, Faculty of Medicine, Kuwait University, Kuwait city, Kuwait.

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http://dx.doi.org/10.1016/j.jacl.2018.02.003DOI Listing
February 2018

Computed tomography angiography defined vulnerable plaque in a patient with low high-density lipoprotein cholesterol and subsequent myocardial infarction.

Coron Artery Dis 2017 12;28(8):712-714

aDepartment of Cardiology, Heart Institute (InCor), School of Medicine from University of São Paulo bDepartment of Cardiology, Hospital Israelita Albert Einstein, São Paulo, Brazil.

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http://dx.doi.org/10.1097/MCA.0000000000000524DOI Listing
December 2017

Genetics and molecular biology controversies on Mendelian randomization and proprotein convertase subtilisin-kexin type 9 inhibitor clinical trials: more data still necessary.

Authors:
Raul D Santos

Curr Opin Lipidol 2017 12;28(6):522-523

aLipid Clinic Heart Institute (InCor), University of Sao Paulo Medical School Hospital bPreventive Medicine Center, Cardiology Program, Hospital Israelita Albert Einstein, Sao Paulo, Brazil.

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http://dx.doi.org/10.1097/MOL.0000000000000460DOI Listing
December 2017

Familial hypercholesterolaemia.

Nat Rev Dis Primers 2017 Dec 7;3:17093. Epub 2017 Dec 7.

Metabolic Medicine and Chemical Pathology, Guy's and St. Thomas' Hospitals, London, UK.

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http://www.nature.com/articles/nrdp201793
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http://dx.doi.org/10.1038/nrdp.2017.93DOI Listing
December 2017

Better health literacy can make the difference when control of risk factors for cardiovascular disease and quality of life are concerned.

Authors:
Raul D Santos

Eur J Prev Cardiol 2017 11 3;24(17):1878-1879. Epub 2017 Oct 3.

Lipid Clinic Heart Institute (InCor), University of Sao Paulo Medical School Hospital and Preventive Medicine Centre and Cardiology Program, Hospital Israelita Albert Einstein, Sao Paulo, Brazil.

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http://dx.doi.org/10.1177/2047487317735721DOI Listing
November 2017

Prevalence, awareness, treatment, and control of high low-density lipoprotein cholesterol in Brazil: Baseline of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil).

J Clin Lipidol 2016 May-Jun;10(3):568-76. Epub 2016 Jan 14.

Center for Clinical and Epidemiologic Research, Hospital Universitario, University of Sao Paulo, Sao Paulo, Brazil; School of Medicine, Department of Internal Medicine, University of Sao Paulo, Sao Paulo, Brazil.

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http://dx.doi.org/10.1016/j.jacl.2015.12.029DOI Listing
October 2017

Extremely elevated HDL-cholesterol levels are not associated with increased carotid intima-media thickness: data from ELSA Brasil.

J Clin Lipidol 2016 Jul-Aug;10(4):898-904.e1. Epub 2016 Mar 21.

Centro de Pesquisa Clínica e Epidemiológica do Hospital Universitário, University of Sao Paulo Medical School, Sao Paulo, Brazil.

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http://dx.doi.org/10.1016/j.jacl.2016.03.007DOI Listing
October 2017

Long-term mipomersen treatment is associated with a reduction in cardiovascular events in patients with familial hypercholesterolemia.

J Clin Lipidol 2016 Jul-Aug;10(4):1011-1021. Epub 2016 May 9.

London School of Hygiene & Tropical Medicine, London, UK. Electronic address:

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http://dx.doi.org/10.1016/j.jacl.2016.04.013DOI Listing
October 2017

Dyslipidemia according to gender and race: The Brazilian Longitudinal Study of Adult Health (ELSA-Brasil).

J Clin Lipidol 2016 Nov - Dec;10(6):1362-1368. Epub 2016 Aug 23.

Center for Clinical and Epidemiological Research, University of Sao Paulo, Brazil. Electronic address:

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http://dx.doi.org/10.1016/j.jacl.2016.08.008DOI Listing
October 2017

Achilles tendon xanthomas are associated with the presence and burden of subclinical coronary atherosclerosis in heterozygous familial hypercholesterolemia: A pilot study.

Atherosclerosis 2017 08 30;263:393-397. Epub 2017 Apr 30.

Lipid Clinic Heart Institute (InCor), University of Sao Paulo Medical School Hospital, Sao Paulo, SP, Brazil; Preventive Medicine Center and Cardiology Program, Hospital Israelita Albert Einstein, Sao Paulo, Brazil. Electronic address:

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http://dx.doi.org/10.1016/j.atherosclerosis.2017.04.025DOI Listing
August 2017

Increased subclinical atherosclerosis burden in familial hypercholesterolemia phenotype: What do genetic defects tell us and what are the clinical implications?

Atherosclerosis 2017 08 12;263:316-317. Epub 2017 Jun 12.

Lipid Clinic Heart Institute (InCor), University of São Paulo, Medical School Hospital, Sao Paulo, Brazil.

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http://dx.doi.org/10.1016/j.atherosclerosis.2017.06.004DOI Listing
August 2017

Detection of atherosclerotic cardiovascular disease influences the perceived need for aggressive lipid management.

Atherosclerosis 2017 Aug 3;263:112-118. Epub 2017 Jun 3.

Mazankowski Alberta Heart Institute, University of Alberta, Edmonton, Alberta, Canada.

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http://dx.doi.org/10.1016/j.atherosclerosis.2017.06.006DOI Listing
August 2017

Lipoprotein(a) and cardiovascular mortality: mystery still unsolved.

Authors:
Raul D Santos

Lancet Diabetes Endocrinol 2017 07 26;5(7):489-490. Epub 2017 May 26.

Lipid Clinic Heart Institute (InCor), University of Sao Paulo Medical School Hospital, Sao Paulo, Brazil; Preventive Medicine Centre and Cardiology Programme, Hospital Israelita Albert Einstein, Sao Paulo, Brazil. Electronic address:

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http://dx.doi.org/10.1016/S2213-8587(17)30101-8DOI Listing
July 2017

Predicting Cardiovascular Events in Familial Hypercholesterolemia: The SAFEHEART Registry (Spanish Familial Hypercholesterolemia Cohort Study).

Circulation 2017 May 8;135(22):2133-2144. Epub 2017 Mar 8.

From Cardiology Department, Hospital Clínico San Carlos, IDISSC, Universidad Complutense, Madrid, Spain (L.P.d.I.); Fundación Hipercolesterolemia Familiar, Madrid, Spain (L.P.d.I., R. Alonso, N.M., A.S., P.M.); Clínica las Condes, Santiago, Chile (R. Alonso); Department of Epidemiology, Madrid Health Authority, Madrid, Spain (N.M.); Clinical Epidemiology Unit, Servicio de Medicina Preventiva, Instituto de Investigación Sanitaria San Carlos, Universidad Complutense, Madrid, Spain (C.F.-P.); Department of Internal Medicine, Hospital Virgen del Rocío, Sevilla, Spain (O.M.); Department of Internal Medicine, Hospital Abente y Lago, A Coruña, Spain (J.L.D.-D.); Cardiology Department, Hospital del Tajo, Universidad Alfonso X el Sabio, Madrid, Spain (A.S.); Lipids and Atherosclerosis Unit, Instituto Maimónides de Investigación Biomédica de Córdoba/Reina Sofia University Hospital/University of Cordoba, Cordoba, Spain (F.F.-J.); Department of Internal Medicine, Fundación Jiménez Díaz, IIS, Madrid, Spain (R.d.A.); Department of Endocrinology, Hospital Clinic, Barcelona, Spain (D.Z.); Department of Internal Medicine, Hospital Universitario de Elche, Alicante, Spain (M.P.); Department of Internal Medicine, Hospital de Vega Baja, Orihuela, Alicante, Spain (J.M.C.); Department of Internal Medicine, Hospital de Terrassa, Barcelona, Spain (M.M.); Department of Internal Medicine, Hospital de Ciudad Real, Spain (J.G.); Department of Internal Medicine, Hospital de San Pedro, Logroño, Spain (A.B.); Department of Internal Medicine, Hospital San Pedro de Alcántara, Cáceres, Spain (J.F.S.M.-T.); Instituto Catalán Ciencias Cardiovasculares, Instituto de Investigación Biomédica-Sant Pau, Barcelona, Spain (T.P., L.B.); Department of Endocrinology, Hospital Universitario de Lugo, Spain (R. Argueso); Department of Internal Medicine, Hospital Universitariode Salamanca, Spain (J.P.M.-G.); Lipid Clinic Heart Institute (InCor), University of São Paulo Medical School Hospital and Preventive Centre and Cardiology Program, Hospital Israelita Albert Einstein, Brazil (R.D.S.); and Lipid Disorders Clinic, Department of Cardiology, Royal Perth Hospital, School of Medicine and Pharmacology, University of Western Australia (G.F.W.).

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http://dx.doi.org/10.1161/CIRCULATIONAHA.116.024541DOI Listing
May 2017

Relation of Fasting Triglyceride-Rich Lipoprotein Cholesterol to Coronary Artery Calcium Score (from the ELSA-Brasil Study).

Am J Cardiol 2017 05 10;119(9):1352-1358. Epub 2017 Feb 10.

Center for Clinical and Epidemiological Research, University Hospital, University of São Paulo School of Medicine, São Paulo, Brazil; University of São Paulo School of Medicine, São Paulo, Brazil.

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http://dx.doi.org/10.1016/j.amjcard.2017.01.033DOI Listing
May 2017

Phenotype vs. genotype in severe familial hypercholesterolemia: what matters most for the clinician?

Authors:
Raul D Santos

Curr Opin Lipidol 2017 Apr;28(2):130-135

Lipid Clinic Heart Institute (InCor) University of Sao Paulo Medical School Hospital and Preventive Medicine Center and Cardiology Program, Hospital Israelita Albert Einstein, Sao Paulo, Brazil.

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http://dx.doi.org/10.1097/MOL.0000000000000391DOI Listing
April 2017

Lipid-Reduction Variability and Antidrug-Antibody Formation with Bococizumab.

N Engl J Med 2017 04 17;376(16):1517-1526. Epub 2017 Mar 17.

From Brigham and Women's Hospital, Harvard Medical School, Boston (P.M.R., R.J.G., L.M.R.); Montreal Heart Institute, Université de Montréal, Montreal (J.-C.T.); Pierre et Marie Curie University, Paris (P.A.); Pfizer, New York (W.D., A.M.K., J.R., P.F.S., C.L.S., C.Y.); Leiden University Medical Center, Leiden (J.W.J.), and Academic Medical Center of the University of Amsterdam, Amsterdam (J.J.P.K.) - both in the Netherlands; Deutsches Herzzentrum München, Technische Universität München, DZHK (German Center for Cardiovascular Research), Munich Heart Alliance, Munich, Germany (W.K.); Cleveland Clinic Foundation, Cleveland (S.N.); and the Lipid Clinic Heart Institute, University of São Paulo Medical School Hospital, São Paulo (R.D.S.).

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http://dx.doi.org/10.1056/NEJMoa1614062DOI Listing
April 2017

Cardiovascular Efficacy and Safety of Bococizumab in High-Risk Patients.

N Engl J Med 2017 04 17;376(16):1527-1539. Epub 2017 Mar 17.

From Brigham and Women's Hospital and Harvard Medical School, Boston (P.M.R., R.J.G.); Pfizer, New York (J.R., R.B., M.C., U.M., P.F.S., C.Y., C.L.S.); Paris-Diderot, Sorbonne Paris Cité University, Paris (P.A.); Universidad de Zaragoza, IIS Aragon, Zaragoza, Spain (F.C.); University of East Anglia, Norwich (M.F.), and Central Manchester University Hospital, Manchester (H.S.) - both in the United Kingdom; the Montreal Heart Institute, Université de Montréal, Montreal (J.G., J.-C.T.); Leiden University Medical Center, Leiden (J.W.J.), Academic Medical Center of the University of Amsterdam, Amsterdam (J.J.P.K.), and Meander Medical Center, Amersfoort (A.M.) - all in the Netherlands; Russian Cardiology Research and Production Center, Moscow (Y.K.); Deutsches Herzzentrum München, Technische Universität München, Munich Heart Alliance, Munich, Germany (W.K.); Cordoba Hospital, Cordoba, Argentina (A.L.); University of the Witwatersrand, Johannesburg (P.M.); University of Maryland, Baltimore (M.M.); University of Comenius, Bratislava, Slovakia (J.M.); Heart Institute, University of São Paulo Medical School (J.C.N.), and Lipid Clinic Heart Institute, University of São Paulo Medical School Hospital (R.D.S.), São Paulo; Cleveland Clinic Foundation, Cleveland (S.N.); Wroclaw Medical University, Wroclaw, Poland (P.P.); Green Lane Cardiovascular Service, Auckland City Hospital, Auckland, New Zealand (H.W.); Mayo Clinic, Rochester, MN (R.S.W.); and First Faculty of Medicine, Charles University, Prague, Czech Republic (M.V.).

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http://dx.doi.org/10.1056/NEJMoa1701488DOI Listing
April 2017

Subclinical carotid vascular disease and risk factors for atherosclerosis in type 1 and type 2 diabetes.

Arch Endocrinol Metab 2017 04;61(2):105-107

Instituto do Coração (InCor), Faculdade de Medicina da Universidade de São Paulo, (FMUSP), São Paulo, SP, Brasil.

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http://dx.doi.org/10.1590/2359-3997000000264DOI Listing
April 2017

Reduced subclinical carotid vascular disease and arterial stiffness in vegetarian men: The CARVOS Study.

Int J Cardiol 2017 Mar 20;230:562-566. Epub 2016 Dec 20.

Lipid Clinic Heart Institute (InCor), University of São Paulo Medical School Hospital, São Paulo, Brazil. Electronic address:

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http://dx.doi.org/10.1016/j.ijcard.2016.12.058DOI Listing
March 2017

PCSK9 Inhibition With Monoclonal Antibodies: Modern Management of Hypercholesterolemia.

J Clin Pharmacol 2017 01 21;57(1):7-32. Epub 2016 Jun 21.

Lipid Clinic, Heart Institute (InCor), University of Sao Paulo Medical School Hospital, and Preventive Medicine Center and Cardiology Program, Hospital Israelita Albert Einstein, Sao Paulo, Brazil.

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http://dx.doi.org/10.1002/jcph.766DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5215586PMC
January 2017

Pooling and expanding registries of familial hypercholesterolaemia to assess gaps in care and improve disease management and outcomes: Rationale and design of the global EAS Familial Hypercholesterolaemia Studies Collaboration.

Atheroscler Suppl 2016 Dec 7;22:1-32. Epub 2016 Dec 7.

Imperial Centre for Cardiovascular Disease Prevention (ICCP), School of Public Health, Imperial College London, London, UK.

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http://dx.doi.org/10.1016/j.atherosclerosissup.2016.10.001DOI Listing
December 2016

Epicardial fat is associated with severity of subclinical coronary atherosclerosis in familial hypercholesterolemia.

Atherosclerosis 2016 11 9;254:73-77. Epub 2016 Sep 9.

Lipid Clinic Heart Institute (InCor), University of Sao Paulo Medical School Hospital, Sao Paulo, SP, Brazil; Preventive Medicine Centre and Cardiology Program Hospital Israelita Albert Einstein, Sao Paulo, Brazil. Electronic address:

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http://dx.doi.org/10.1016/j.atherosclerosis.2016.09.010DOI Listing
November 2016

Proprotein Convertase Subtilisin Kexin Type 9 Inhibition for Autosomal Recessive Hypercholesterolemia-Brief Report.

Arterioscler Thromb Vasc Biol 2016 08 14;36(8):1647-50. Epub 2016 Apr 14.

From the Inra UMR 1280, Université de Nantes, Faculté de Médecine, Nantes, France (A.T., M.P., S.P.-F., A.G., M.C., G.L.); Department of Vascular Medicine, Academic Medical Centre, Amsterdam, The Netherlands (B.S., G.D.-T., J.P., K.H.); Lipidology Division of Internal Medicine, University of Cape Town, Cape Town, South Africa (D.B.); Dipartimiento di Nefrologia Dialisi e Trapianto, SS Annunziata Hospital, Sassari, Italy (M.C., M.C.); University of Palermo, School of Medicine, Palermo, Italy (A.B.C., M.A.); University of Genoa, Genoa, Italy (L.P.); Lipid Clinic Heart Institute (InCor) University of Sao Paulo Medica School Hospital, Sao Paulo, Brazil (R.D.S.); Faculty of Health Sciences, University of Witwatersrand, Johannesburg, South Africa (F.R.); Dipartimento di Medicina Interna, Brotzu Hospital, Cagliari, Italy (P.P.); Inserm UMR 1188, Sainte Clotilde, France (G.L.); Université de la Réunion, Faculté de Médecine, Saint Denis de la Réunion, France (G.L.); and CHU de la Réunion, Saint-Denis de la Réunion, France (G.L.).

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http://dx.doi.org/10.1161/ATVBAHA.116.307493DOI Listing
August 2016

Familial hypercholesterolaemia: beware of lipoprotein(a).

Authors:
Raul D Santos

Lancet Diabetes Endocrinol 2016 07 13;4(7):553-5. Epub 2016 May 13.

Lipid Clinic Heart Institute (InCor), University of São Paulo Medical School Hospital and Preventive Medicine Centre and Cardiology Program, Hospital Israelita Albert Einstein, São Paulo, SP 05403, Brazil. Electronic address:

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http://dx.doi.org/10.1016/S2213-8587(16)30082-1DOI Listing
July 2016

Predictors of cardiovascular events after one year of molecular screening for Familial hypercholesterolemia.

Atherosclerosis 2016 07 15;250:144-50. Epub 2016 May 15.

Laboratory of Genetics and Molecular Cardiology, Heart Institute (InCor), University of São Paulo Medical School Hospital, São Paulo, Brazil.

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http://dx.doi.org/10.1016/j.atherosclerosis.2016.05.023DOI Listing
July 2016

Homozygous familial hypercholesterolemia: phenotype rules!

Authors:
Raul D Santos

Atherosclerosis 2016 May 14;248:252-4. Epub 2016 Mar 14.

Lipid Clinic Heart Institute (InCor) University of Sao Paulo Medical School Hospital and Preventive Medicine Centre and Cardiology Program Hospital Israelita Albert Einstein, Sao Paulo, Brazil. Electronic address:

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http://dx.doi.org/10.1016/j.atherosclerosis.2016.03.015DOI Listing
May 2016

Elevated gamma-glutamyl transferase is associated with subclinical inflammation independent of cardiometabolic risk factors in an asymptomatic population: a cross-sectional study.

Nutr Metab (Lond) 2016 18;13:37. Epub 2016 May 18.

Center for Healthcare Advancement and Outcomes, Baptist Health Medical Group, 1691 Michigan Avenue Suite 500, Miami, FL 33139 USA ; Johns Hopkins Ciccarone Center for the Prevention of Heart Disease, Johns Hopkins University, Baltimore, MD USA ; Robert Stempel College of Public Health, Florida International University, Miami, FL USA ; Herbert Wertheim College of Medicine, Florida International University, Miami, FL USA.

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http://dx.doi.org/10.1186/s12986-016-0097-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4870806PMC
May 2016

Association between a healthy cardiovascular risk factor profile and coronary artery calcium score: Results from the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil).

Am Heart J 2016 Apr 4;174:51-9. Epub 2016 Jan 4.

Centro de Pesquisa Clínica e Epidemiológica, Hospital Universitário, Universidade de São Paulo, São Paulo, Brazil; Faculdade Medicina da Universidade de São Paulo, São Paulo, Brazil.

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http://dx.doi.org/10.1016/j.ahj.2015.12.018DOI Listing
April 2016