Ratko Djukanovic

Ratko Djukanovic

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Ratko Djukanovic

Publications by authors named "Ratko Djukanovic"

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Advancing Understanding of Mechanisms of Severe Asthma and Drug Effects Using Transcriptomics.

Am J Respir Crit Care Med 2019 Oct;200(7):795-796

Faculty of MedicineUniversity of SouthamptonSouthampton, United Kingdomand.

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http://dx.doi.org/10.1164/rccm.201905-0953EDDOI Listing
October 2019

Regarding epithelial dysregulation in obese severe asthmatics with gastro-oesophageal reflux.

Eur Respir J 2019 Oct 10;54(4). Epub 2019 Oct 10.

NIHR Southampton Biomedical Research Centre, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK.

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http://dx.doi.org/10.1183/13993003.01805-2019DOI Listing
October 2019

Biomarker-based corticosteroid adjustment in severe asthma: a modified Delphi consensus.

ERJ Open Res 2018 Oct 7;4(4). Epub 2018 Dec 7.

Centre for Experimental Medicine, School of Medicine, Dentistry and Biomedical Sciences, Queen's University, Belfast, UK.

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http://dx.doi.org/10.1183/23120541.00081-2018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6284095PMC
October 2018

Lung Topology Characteristics in patients with Chronic Obstructive Pulmonary Disease.

Sci Rep 2018 03 28;8(1):5341. Epub 2018 Mar 28.

Mathematical Sciences, University of Southampton, Southampton, UK.

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http://dx.doi.org/10.1038/s41598-018-23424-0DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5871819PMC
March 2018

Sputum transcriptomics reveal upregulation of IL-1 receptor family members in patients with severe asthma.

J Allergy Clin Immunol 2018 02 18;141(2):560-570. Epub 2017 May 18.

Airways Disease, National Heart & Lung Institute, Imperial College London, and the Biomedical Research Unit, Royal Brompton & Harefield NHS Trust, London, United Kingdom; Priority Research Centre for Healthy Lungs, Hunter Medical Research Institute, University of Newcastle, Newcastle, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2017.02.045DOI Listing
February 2018

Predicting Asthmatic Responses to Inhaled Allergen Using an Unbiased Transcriptomics Approach.

Am J Respir Crit Care Med 2018 02;197(4):415-416

1 Faculty of Medicine University of Southampton Southampton, United Kingdom and.

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http://dx.doi.org/10.1164/rccm.201711-2237EDDOI Listing
February 2018

Physiotherapy breathing retraining for asthma: a randomised controlled trial.

Lancet Respir Med 2018 01 14;6(1):19-28. Epub 2017 Dec 14.

NIHR Southampton Biomedical Research Centre, Southampton, UK; Primary Care and Population Sciences, Faculty of Medicine, University of Southampton, Southampton, UK; Asthma UK Centre for Applied Research, University of Edinburgh, Edinburgh, UK. Electronic address:

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http://dx.doi.org/10.1016/S2213-2600(17)30474-5DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5757422PMC
January 2018

Care pathways for the selection of a biologic in severe asthma.

Eur Respir J 2017 12 7;50(6). Epub 2017 Dec 7.

Dept of Pulmonary and Critical Care Medicine, National Jewish Health, Denver, CO, USA.

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http://dx.doi.org/10.1183/13993003.01782-2017DOI Listing
December 2017

Squamous Metaplasia Is Increased in the Bronchial Epithelium of Smokers with Chronic Obstructive Pulmonary Disease.

PLoS One 2016 26;11(5):e0156009. Epub 2016 May 26.

Academic Unit of Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0156009PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4881906PMC
July 2017

Susceptibility to influenza virus infection of bronchial biopsies in asthma.

J Allergy Clin Immunol 2017 07 1;140(1):309-312.e4. Epub 2017 Mar 1.

Clinical and Experimental Sciences, University of Southampton Faculty of Medicine, Sir Henry Wellcome Laboratories, Southampton General Hospital, Southampton, United Kingdom; Southampton NIHR Respiratory Biomedical Research Unit and the NIHR Wellcome Trust Clinical Research Facility, Southampton General Hospital, Southampton, United Kingdom.

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http://dx.doi.org/10.1016/j.jaci.2016.12.964DOI Listing
July 2017

Viral Inhibition of Bacterial Phagocytosis by Human Macrophages: Redundant Role of CD36.

PLoS One 2016 4;11(10):e0163889. Epub 2016 Oct 4.

Clinical and Experimental Sciences, University of Southampton Faculty of Medicine, Sir Henry Wellcome Laboratories, Southampton General Hospital, Tremona Road, Southampton, SO16 6YD, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0163889PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5049764PMC
June 2017

Targeting Eosinophils in Eosinophilic Granulomatosis with Polyangiitis.

N Engl J Med 2017 05;376(20):1985-1986

From Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, and National Institute for Health Research Southampton Biomedical Research Centre, Southampton, United Kingdom (R.D.); and Firestone Institute for Respiratory Health, St. Joseph's Healthcare, and the Department of Medicine, Michael G. DeGroote School of Medicine, McMaster University, Hamilton, ON, Canada (P.M.O.).

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http://dx.doi.org/10.1056/NEJMe1704402DOI Listing
May 2017

Metabolomics analysis identifies different metabotypes of asthma severity.

Eur Respir J 2017 03 29;49(3). Epub 2017 Mar 29.

Division of Physiological Chemistry 2, Dept of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm, Sweden

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http://dx.doi.org/10.1183/13993003.01740-2016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5399350PMC
March 2017

The era of research collaborations: new models for working together.

Eur Respir J 2017 01 3;49(1). Epub 2017 Jan 3.

Division of Infection, Immunity and Respiratory Medicine, Faculty of Biology, Medicine and Health, University of Manchester, Manchester, UK.

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http://dx.doi.org/10.1183/13993003.01848-2016DOI Listing
January 2017

Multidimensional endotyping in patients with severe asthma reveals inflammatory heterogeneity in matrix metalloproteinases and chitinase 3-like protein 1.

J Allergy Clin Immunol 2016 07 3;138(1):61-75. Epub 2016 Feb 3.

Clinical and Experimental Sciences, University of Southampton Faculty of Medicine, Sir Henry Wellcome Laboratories, Southampton University Hospital, Southampton, United Kingdom; NIHR Southampton Respiratory Biomedical Research Unit, Southampton University Hospital, Southampton, United Kingdom.

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http://dx.doi.org/10.1016/j.jaci.2015.11.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4929135PMC
July 2016

IgE-mediated asthma: New revelations and future insights.

Respir Med 2016 Mar 30;112:128-9. Epub 2015 Oct 30.

University of Aberdeen, Aberdeen, UK.

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http://dx.doi.org/10.1016/j.rmed.2015.10.013DOI Listing
March 2016

Randomized controlled trial of primary prevention of atopy using house dust mite allergen oral immunotherapy in early childhood.

J Allergy Clin Immunol 2015 Dec 12;136(6):1541-1547.e11. Epub 2015 Jun 12.

NIHR Southampton Respiratory Biomedical Research Unit, University Hospital Southampton NHS Foundation Trust, Southampton, United Kingdom; Clinical and Experimental Sciences Academic Unit, University of Southampton Faculty of Medicine, Southampton, United Kingdom; David Hide Asthma and Allergy Research Centre, St Mary's Hospital, Isle of Wight, United Kingdom; Department of Respiratory Medicine, University Hospital Southampton NHS Foundation Trust, Southampton, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.jaci.2015.04.045DOI Listing
December 2015

Viral infection of human lung macrophages increases PDL1 expression via IFNβ.

PLoS One 2015 16;10(3):e0121527. Epub 2015 Mar 16.

Academic Unit of Clinical and Experimental Sciences, University of Southampton Faculty of Medicine, Sir Henry Wellcome Laboratories, Southampton General Hospital, Southampton, United Kingdom; Southampton NIHR Respiratory Biomedical Research Unit, Southampton General Hospital, Southampton, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0121527PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4361055PMC
October 2015

Innate and adaptive T cells in asthmatic patients: Relationship to severity and disease mechanisms.

J Allergy Clin Immunol 2015 Aug 5;136(2):323-33. Epub 2015 Mar 5.

Clinical and Experimental Sciences, University of Southampton Faculty of Medicine, Sir Henry Wellcome Laboratories, Southampton University Hospital, Southampton, United Kingdom; NIHR Southampton Respiratory Biomedical Research Unit, Southampton University Hospital, Southampton, United Kingdom. Electronic address:

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https://www.researchgate.net/profile/Borislav_D_Dimitrov/pub
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http://linkinghub.elsevier.com/retrieve/pii/S009167491500104
Publisher Site
http://dx.doi.org/10.1016/j.jaci.2015.01.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4534770PMC
August 2015

A novel lung explant model for the ex vivo study of efficacy and mechanisms of anti-influenza drugs.

J Immunol 2015 Jun 1;194(12):6144-54. Epub 2015 May 1.

Clinical and Experimental Sciences, University of Southampton Faculty of Medicine, Sir Henry Wellcome Laboratories, Southampton General Hospital, Southampton SO16 6YD, United Kingdom; Southampton National Institute for Health Research Respiratory Biomedical Research Unit, Southampton General Hospital, Southampton SO16 6YD, United Kingdom;

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http://dx.doi.org/10.4049/jimmunol.1402283DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4456633PMC
June 2015

Multidimensional endotypes of asthma: topological data analysis of cross-sectional clinical, pathological, and immunological data.

Lancet 2015 Feb;385 Suppl 1:S42

Clinical and Experimental Sciences, University of Southampton Faculty of Medicine, Sir Henry Wellcome Laboratories, Southampton University Hospital, Southampton, UK.

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https://linkinghub.elsevier.com/retrieve/pii/S01406736156035
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http://dx.doi.org/10.1016/S0140-6736(15)60357-9DOI Listing
February 2015

Epigenomic analysis of primary human T cells reveals enhancers associated with TH2 memory cell differentiation and asthma susceptibility.

Nat Immunol 2014 Aug 6;15(8):777-88. Epub 2014 Jul 6.

1] La Jolla Institute for Allergy & Immunology, La Jolla, California, USA. [2] Clinical and Experimental Sciences, Southampton National Institute for Health Research Respiratory Biomedical Research Unit, University of Southampton, Faculty of Medicine, Southampton, UK. [3] University of California San Francisco, San Francisco, California, USA.

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http://dx.doi.org/10.1038/ni.2937DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4140783PMC
August 2014

The effect of inhaled IFN-β on worsening of asthma symptoms caused by viral infections. A randomized trial.

Am J Respir Crit Care Med 2014 Jul;190(2):145-54

1 NIHR Southampton Respiratory Biomedical Research Unit, Clinical and Experimental Sciences, University of Southampton Faculty of Medicine, Southampton, United Kingdom.

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http://dx.doi.org/10.1164/rccm.201312-2235OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4226052PMC
July 2014

EGF-induced bronchial epithelial cells drive neutrophil chemotactic and anti-apoptotic activity in asthma.

PLoS One 2013 11;8(9):e72502. Epub 2013 Sep 11.

Academic Unit of Clinical and Experimental Sciences and the NIHR Southampton Respiratory Biomedical Research Unit, Southampton University Faculty of Medicine, Sir Henry Wellcome Laboratories, Southampton University Hospital, Southampton, United Kingdom.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0072502PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3770689PMC
June 2014

Phenotypic characterization of lung macrophages in asthmatic patients: overexpression of CCL17.

J Allergy Clin Immunol 2012 Dec 14;130(6):1404-12.e7. Epub 2012 Sep 14.

Academic Unit of Clinical and Experimental Sciences, University of Southampton Faculty of Medicine, Sir Henry Wellcome Laboratories, Southampton General Hospital, Southampton, United Kingdom.

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http://dx.doi.org/10.1016/j.jaci.2012.07.023DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3805016PMC
December 2012

An integrated nano-scale approach to profile miRNAs in limited clinical samples.

Am J Clin Exp Immunol 2012 Nov;1(2):70-89

Sandler Asthma Basic Research Center, University of California San Francisco, San Francisco, CA, USA ; Division of Infection, Inflammation and Immunity, University of outhampton, School of Medicine, Southampton NIHR Respiratory Biomedical Research Unit, Sir Henry Wellcome Laboratories, Southampton General Hospital, Southampton, UK ; Pulmonary and Critical Care Division, Department of Medicine, University of California San Francisco.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3538381PMC
November 2012

Prosurvival activity for airway neutrophils in severe asthma.

Thorax 2010 Aug;65(8):684-9

Southampton NIHR Respiratory Biomedical Research Unit, Division of Infection, Inflammation and Immunity, University of Southampton School of Medicine, Sir Henry Wellcome Laboratories, South Block, Southampton General Hospital, Southampton, UK.

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http://thorax.bmj.com/cgi/doi/10.1136/thx.2009.120741
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http://dx.doi.org/10.1136/thx.2009.120741DOI Listing
August 2010

An integrative systems biology approach to understanding pulmonary diseases.

Chest 2010 Jun;137(6):1410-6

Functional Genomics and Systems Biology for Health, CNRS Institute of Biological Sciences, 7 rue Guy Moquet-BP8, 94801 Villejuif cedex, France.

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http://dx.doi.org/10.1378/chest.09-1850DOI Listing
June 2010

Identification of lipocalin and apolipoprotein A1 as biomarkers of chronic obstructive pulmonary disease.

Am J Respir Crit Care Med 2010 May 28;181(10):1049-60. Epub 2010 Jan 28.

Inflammatory Cell Biology Group, Division of Infection, Inflammation, and Immunity, Sir Henry Wellcome Laboratories, South Block, Southampton General Hospital, Southampton, UK.

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http://dx.doi.org/10.1164/rccm.200906-0857OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2874448PMC
May 2010

Chemokine receptor 4 plays a key role in T cell recruitment into the airways of asthmatic patients.

J Immunol 2010 Apr 17;184(8):4568-74. Epub 2010 Mar 17.

Division of Infection, Southampton National Institute of Health Research Respiratory Biomedical Research Unit, University of Southampton School of Medicine, Southampton, United Kingdom.

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http://www.jimmunol.org/cgi/doi/10.4049/jimmunol.0901342
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http://dx.doi.org/10.4049/jimmunol.0901342DOI Listing
April 2010

Elevation of sputum matrix metalloproteinase-9 persists up to 6 months after smoking cessation: a research study.

BMC Pulm Med 2010 Mar 14;10:13. Epub 2010 Mar 14.

Department of Medicine, Division of Pulmonary Medicine, University of Helsinki, Helsinki, Finland.

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http://dx.doi.org/10.1186/1471-2466-10-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2841651PMC
March 2010

Induced sputum: a window to lung pathology.

Biochem Soc Trans 2009 Aug;37(Pt 4):868-72

Division of Infection, Inflammation and Immunity, University of Southampton School of Medicine, Southampton SO16 6YD, UK.

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http://dx.doi.org/10.1042/BST0370868DOI Listing
August 2009

From proteomics to prescription-the search for COPD biomarkers.

COPD 2009 Aug;6(4):298-303

Division of Infection, Inflammation and Repair, School of Medicine, Southampton General Hospital, Tremona Road, Southampton, SO16 6YD, UK.

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August 2009

Virus infection, asthma, and chronic obstructive pulmonary disease.

N Engl J Med 2008 Nov;359(19):2062-4

Division of Infection, Inflammation and Repair, Southampton General Hospital, Southampton, United Kingdom.

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http://dx.doi.org/10.1056/NEJMcibr0806978DOI Listing
November 2008

Invariant natural killer T cells in asthma and chronic obstructive pulmonary disease.

N Engl J Med 2007 Apr;356(14):1410-22

Division of Infection, Inflammation, and Repair, University of Southampton, Southampton General Hospital, Southampton, United Kingdom.

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http://dx.doi.org/10.1056/NEJMoa064691DOI Listing
April 2007

Impaired neutrophil chemotaxis in chronic obstructive pulmonary disease.

Am J Respir Crit Care Med 2007 Mar 16;175(5):473-9. Epub 2006 Nov 16.

Allergy & Inflammation Research, Division of Infection, Inflammation, and Repair, Mailpoint 810, Level F, South Block, University of Southampton School of Medicine, Southampton General Hospital, Southampton SO16 6YD, UK.

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http://dx.doi.org/10.1164/rccm.200507-1152OCDOI Listing
March 2007

Shotgun proteomic analysis of human-induced sputum.

Proteomics 2006 Aug;6(15):4390-401

Division of Infection, Inflammation and Repair, School of Medicine, Southampton General Hospital, Southampton, UK.

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http://doi.wiley.com/10.1002/pmic.200600011
Publisher Site
http://dx.doi.org/10.1002/pmic.200600011DOI Listing
August 2006

Effects of treatment with anti-immunoglobulin E antibody omalizumab on airway inflammation in allergic asthma.

Am J Respir Crit Care Med 2004 Sep 1;170(6):583-93. Epub 2004 Jun 1.

Respiratory Cell and Molecular Biology, Division of Infection, Inflammation, and Repair, University of Southampton, Southampton, UK.

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http://dx.doi.org/10.1164/rccm.200312-1651OCDOI Listing
September 2004

Contribution of eotaxin-1 to eosinophil chemotactic activity of moderate and severe asthmatic sputum.

Am J Respir Crit Care Med 2004 May 4;169(10):1110-7. Epub 2004 Mar 4.

Respiratory Cell and Molecular Biology, Division of Infection, Inflammation, and Repair, University of Southampton School of Medicine, Southampton, United Kingdom.

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http://dx.doi.org/10.1164/rccm.200306-855OCDOI Listing
May 2004

Measurement of eotaxin (CCL11) in induced sputum supernatants: validation and detection in asthma.

J Allergy Clin Immunol 2004 Apr;113(4):657-62

Department of Respiratory Cell and Molecular Biology, Division of Infection, Inflammation and Repair, University of Southampton School of Medicine, General Hospital, Tremona Road, Southampton SO16 6YD, United Kingdom.

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http://dx.doi.org/10.1016/j.jaci.2004.01.757DOI Listing
April 2004

Effect of inhaled fluticasone with and without salmeterol on airway inflammation in asthma.

J Allergy Clin Immunol 2003 Jul;112(1):72-8

Department of Respiratory Medicine and Allergy, University Hospital, Umeå.

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http://dx.doi.org/10.1067/mai.2003.1518DOI Listing
July 2003

Increased expression of p21(waf) cyclin-dependent kinase inhibitor in asthmatic bronchial epithelium.

Am J Respir Cell Mol Biol 2003 Jan;28(1):61-8

The Brooke Laboratory, Division of Infection, Inflammation and Repair, School of Medicine, Southampton General Hospital, Southampton, United Kingdom.

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http://dx.doi.org/10.1165/rcmb.4715DOI Listing
January 2003

Differential roles of IL-16 and CD28/B7 costimulation in the generation of T-lymphocyte chemotactic activity in the bronchial mucosa of mild and moderate asthmatic individuals.

J Allergy Clin Immunol 2002 Dec;110(6):906-14

Respiratory Cell & Molecular Biology Section, Division of Infection Inflammation & Repair, University of Southampton School of Medicine, United Kingdom.

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http://dx.doi.org/10.1067/mai.2002.130049DOI Listing
December 2002

Asthmatic bronchial epithelium is more susceptible to oxidant-induced apoptosis.

Am J Respir Cell Mol Biol 2002 Aug;27(2):179-85

School of Medicine, University of Southampton, Southampton General Hospital, Southampton, United Kingdom.

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http://dx.doi.org/10.1165/ajrcmb.27.2.4699DOI Listing
August 2002

Cooperative effects of Th2 cytokines and allergen on normal and asthmatic bronchial epithelial cells.

J Immunol 2002 Jul;169(1):407-14

School of Medicine, Respiratory Cell and Molecular Biology Division, Southampton General Hospital, Southampton, United Kingdom.

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http://dx.doi.org/10.4049/jimmunol.169.1.407DOI Listing
July 2002

Autocrine ligands for the epidermal growth factor receptor mediate interleukin-8 release from bronchial epithelial cells in response to cigarette smoke.

Am J Respir Cell Mol Biol 2002 Jul;27(1):85-90

Respiratory Cell and Molecular Biology Division, School of Medicine, Southampton General Hospital, United Kingdom.

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http://dx.doi.org/10.1165/ajrcmb.27.1.4789DOI Listing
July 2002

Airway inflammation in asthma and its consequences: implications for treatment in children and adults.

Authors:
Ratko Djukanovic

J Allergy Clin Immunol 2002 Jun;109(6 Suppl):S539-48

Southampton University, Southampton, England.

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http://dx.doi.org/10.1067/mai.2002.124568DOI Listing
June 2002