Rashmin C Savani

Rashmin C Savani

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Rashmin C Savani

Rashmin C Savani

Publications by authors named "Rashmin C Savani"

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Early predictors of continuous positive airway pressure failure in preterm neonates.

J Perinatol 2019 Aug 14;39(8):1081-1088. Epub 2019 May 14.

Division of Neonatal-Perinatal Medicine, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX, USA.

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http://www.nature.com/articles/s41372-019-0392-z
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http://dx.doi.org/10.1038/s41372-019-0392-zDOI Listing
August 2019

The Receptor for Hyaluronan-Mediated Motility (CD168) promotes inflammation and fibrosis after acute lung injury.

Matrix Biol 2019 05 8;78-79:255-271. Epub 2018 Aug 8.

Division of Neonatology, Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA, USA; Center for Pulmonary & Vascular Biology, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX, USA; Division of Neonatal-Perinatal Medicine, Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S0945053X183002
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http://dx.doi.org/10.1016/j.matbio.2018.08.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368477PMC
May 2019

Hyaluronan biology: A complex balancing act of structure, function, location and context.

Matrix Biol 2019 05 23;78-79:1-10. Epub 2019 Feb 23.

Division of Intramural Research, National Institute of Environmental Health Sciences, Research Triangle Park, NC, USA; Center for Pulmonary & Vascular Biology, Division of Neonatal-Perinatal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA. Electronic address:

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http://dx.doi.org/10.1016/j.matbio.2019.02.002DOI Listing
May 2019

Ceramides, Autophagy, and Apoptosis Mechanisms of Ventilator-induced Lung Injury and Potential Therapeutic Targets.

Am J Respir Crit Care Med 2019 Mar;199(6):687-689

2 Department of Pediatrics University of Texas Southwestern Medical Center Dallas, Texas.

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https://www.atsjournals.org/doi/10.1164/rccm.201810-1857ED
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http://dx.doi.org/10.1164/rccm.201810-1857EDDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6423105PMC
March 2019

The receptor for hyaluronan-mediated motility (RHAMM) expression in neonatal bronchiolar epithelium correlates negatively with lung air content.

Early Hum Dev 2018 12 10;127:58-68. Epub 2018 Oct 10.

Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden.

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https://linkinghub.elsevier.com/retrieve/pii/S03783782183019
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http://dx.doi.org/10.1016/j.earlhumdev.2018.10.002DOI Listing
December 2018

Modulators of inflammation in Bronchopulmonary Dysplasia.

Authors:
Rashmin C Savani

Semin Perinatol 2018 11 2;42(7):459-470. Epub 2018 Oct 2.

Center for Pulmonary & Vascular Biology, Division of Neonatal-Perinatal Medicine, The Department of Pediatrics, The University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390-9063, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S01460005183008
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http://dx.doi.org/10.1053/j.semperi.2018.09.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6368974PMC
November 2018

Fetal-placental crosstalk occurs through fetal cytokine synthesis and placental clearance.

Placenta 2018 09 10;69:1-8. Epub 2018 Jul 10.

Division of Neonatal-Perinatal Medicine, University of Texas Southwestern Medical Center, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S01434004183066
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http://dx.doi.org/10.1016/j.placenta.2018.07.006DOI Listing
September 2018

Deletion of Hyaluronan Synthase 3 Inhibits Neointimal Hyperplasia in Mice.

Arterioscler Thromb Vasc Biol 2016 Feb 19;36(2):e9-16. Epub 2015 Nov 19.

Institut für Pharmakologie und Klinische Pharmakologie, Universitätsklinikum der Heinrich-Heine-Universität Düsseldorf, Düsseldorf, Germany.

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http://dx.doi.org/10.1161/ATVBAHA.115.306607DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5222548PMC
February 2016

The NLRP3 inflammasome is critically involved in the development of bronchopulmonary dysplasia.

Nat Commun 2015 Nov 27;6:8977. Epub 2015 Nov 27.

Department of Pediatrics, Center for Pulmonary &Vascular Biology, University of Texas Southwestern Medical Center 5323 Harry Hines Boulevard, Dallas Texas 75390-9063, USA.

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http://dx.doi.org/10.1038/ncomms9977DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6215764PMC
November 2015

Maternal high-fat diet is associated with impaired fetal lung development.

Am J Physiol Lung Cell Mol Physiol 2015 Aug 19;309(4):L360-8. Epub 2015 Jun 19.

Touchstone Diabetes Center, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas; and

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http://dx.doi.org/10.1152/ajplung.00105.2015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4538234PMC
August 2015

Proteobacteria-specific IgA regulates maturation of the intestinal microbiota.

Gut Microbes 2014 Jan-Feb;5(1):28-39. Epub 2013 Sep 25.

Department of Immunology; University of Texas Southwestern Medical Center; Dallas, TX USA.

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http://www.tandfonline.com/doi/abs/10.4161/gmic.26489
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http://dx.doi.org/10.4161/gmic.26489DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4049932PMC
January 2015

Resuscitation of preterm neonates with limited versus high oxygen strategy.

Pediatrics 2013 Dec 11;132(6):e1488-96. Epub 2013 Nov 11.

The University of Texas Southwestern Medical Center at Dallas, Department of Pediatrics, Division of Neonatal-Perinatal Medicine, 5323 Harry Hines Blvd, Dallas, TX 75390-9063.

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http://dx.doi.org/10.1542/peds.2013-0978DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3838529PMC
December 2013

Neonatal effects of magnesium sulfate given to the mother.

Am J Perinatol 2012 Nov 6;29(10):795-9. Epub 2012 Jul 6.

Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9032, USA.

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http://dx.doi.org/10.1055/s-0032-1316440DOI Listing
November 2012

Toll-like receptor 2 (TLR2), transforming growth factor-β, hyaluronan (HA), and receptor for HA-mediated motility (RHAMM) are required for surfactant protein A-stimulated macrophage chemotaxis.

J Biol Chem 2012 Oct 4;287(44):37406-19. Epub 2012 Sep 4.

Division of Pharmacology and Toxicology, Department of Pharmaceutical Sciences, University of the Sciences in Philadelphia, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1074/jbc.M112.360982DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3481337PMC
October 2012

Toll-like receptors, the NLRP3 inflammasome, and interleukin-1β in the development and progression of type 1 diabetes.

Pediatr Res 2012 Jun 15;71(6):626-32. Epub 2012 Feb 15.

Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, Texas, USA.

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http://www.nature.com/articles/pr201224
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http://dx.doi.org/10.1038/pr.2012.24DOI Listing
June 2012

Inhibition of oesophageal squamous cell carcinoma progression by in vivo targeting of hyaluronan synthesis.

Mol Cancer 2011 Mar 23;10:30. Epub 2011 Mar 23.

Institut für Pharmakologie und Klinische Pharmakologie, Universitätsklinikum Düsseldorf, Heinrich-Heine Universität Düsseldorf, Düsseldorf, Germany.

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http://dx.doi.org/10.1186/1476-4598-10-30DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3078897PMC
March 2011

Hyaluronan stabilizes focal adhesions, filopodia, and the proliferative phenotype in esophageal squamous carcinoma cells.

J Biol Chem 2010 Jul 12;285(30):23276-84. Epub 2010 May 12.

Institut für Pharmakologie, Universitätsklinikum Essen, Universität Duisburg-Essen, 45147 Essen, Germany.

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http://dx.doi.org/10.1074/jbc.M109.093146DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2906320PMC
July 2010

The angiogenic factor midkine is regulated by dexamethasone and retinoic acid during alveolarization and in alveolar epithelial cells.

Respir Res 2009 Aug 21;10:77. Epub 2009 Aug 21.

Division of Neonatology, Department of Pediatrics, Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.

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http://respiratory-research.biomedcentral.com/articles/10.11
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http://dx.doi.org/10.1186/1465-9921-10-77DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2739515PMC
August 2009

Hyaluronan mediates ozone-induced airway hyperresponsiveness in mice.

J Biol Chem 2009 Apr 21;284(17):11309-17. Epub 2009 Jan 21.

NIEHS, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA.

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http://dx.doi.org/10.1074/jbc.M802400200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2670136PMC
April 2009

S-nitrosylation of surfactant protein-D controls inflammatory function.

PLoS Biol 2008 Nov;6(11):e266

Department of Pharmacology and Toxicology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, New Jersey, USA.

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http://dx.doi.org/10.1371/journal.pbio.0060266DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2581630PMC
November 2008

Interaction of CD44 and hyaluronan is the dominant mechanism for neutrophil sequestration in inflamed liver sinusoids.

J Exp Med 2008 Apr 24;205(4):915-27. Epub 2008 Mar 24.

Immunology Research Group, Department of Physiology and Biophysics, Institute of Infection, Immunity and Inflammation, University of Calgary, Alberta T2N 4N1, Canada.

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http://dx.doi.org/10.1084/jem.20071765DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2292228PMC
April 2008

Apical oxidative hyaluronan degradation stimulates airway ciliary beating via RHAMM and RON.

Am J Respir Cell Mol Biol 2007 Aug 29;37(2):160-8. Epub 2007 Mar 29.

Division of Pulmonary and Critical Care Medicine, University of Miami Miller School of Medicine, 1600 NW 10th Ave., RMSB 7063A (R-47), Miami, FL 33136, USA.

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http://dx.doi.org/10.1165/rcmb.2006-0413OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1976543PMC
August 2007

CD44 regulates macrophage recruitment to the lung in lipopolysaccharide-induced airway disease.

Am J Respir Cell Mol Biol 2007 Aug 19;37(2):248-53. Epub 2007 Apr 19.

Division of Pulmonary, Allergy, and Critical Care Medicine, DUMC 3136, Duke University Medical Center, Durham, NC 27710, USA.

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http://dx.doi.org/10.1165/rcmb.2006-0363OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1976546PMC
August 2007

ABCA3 is critical for lamellar body biogenesis in vivo.

J Biol Chem 2007 Aug 31;282(33):23811-7. Epub 2007 May 31.

Department of Physiology, University of Pennsylvania School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.

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http://dx.doi.org/10.1074/jbc.M703927200DOI Listing
August 2007

SP-D-deficient mice are resistant to hyperoxia.

Am J Physiol Lung Cell Mol Physiol 2007 Apr 8;292(4):L861-71. Epub 2006 Dec 8.

Pulmonary and Critical Care Division, University of Pennsylvania School of Medicine, Room H410F, Hill Pavilion, 380 South University Ave., Philadelphia, PA 19107, USA.

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http://dx.doi.org/10.1152/ajplung.00145.2006DOI Listing
April 2007

Inflammatory markers and mediators in tracheal fluid of premature infants treated with inhaled nitric oxide.

Pediatrics 2007 Apr;119(4):670-8

Department of Pediatrics, Section of Neonatology, Children's Mercy Hospitals and Clinics, University of Missouri-Kansas City School of Medicine, 2401 Gillham Rd, Kansas City, MO 64108, USA.

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http://dx.doi.org/10.1542/peds.2006-2683DOI Listing
April 2007

Role of endogenous TGF-beta in glucocorticoid-induced lung type II cell differentiation.

Am J Physiol Lung Cell Mol Physiol 2007 Jan 22;292(1):L249-57. Epub 2006 Sep 22.

Division of Neonatology, Department of Pediatrics, University of California-San Francisco, 3333 California St., Suite 150, San Francisco, CA 94118-1981, USA.

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http://dx.doi.org/10.1152/ajplung.00088.2006DOI Listing
January 2007

Hyaluronan-mediated angiogenesis in vascular disease: uncovering RHAMM and CD44 receptor signaling pathways.

Matrix Biol 2007 Jan 19;26(1):58-68. Epub 2006 Sep 19.

School of Biology, Chemistry and Health Science, Manchester Metropolitan University, Manchester, UK.

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http://dx.doi.org/10.1016/j.matbio.2006.08.261DOI Listing
January 2007

Involvement of endothelial CD44 during in vivo angiogenesis.

Am J Pathol 2006 Jul;169(1):325-36

Pulmonary, Allergy and Critical Care Division, Department of Medicine, Division of Neonatology, Children's Hospital of Philadelphia, Philadelphia, PA, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1698758PMC
http://dx.doi.org/10.2353/ajpath.2006.060206DOI Listing
July 2006

Loss of PECAM-1 function impairs alveolarization.

J Biol Chem 2006 Mar 23;281(13):8724-31. Epub 2005 Dec 23.

Pulmonary, Allergy and Critical Care Division, Department of Medicine, Institute for Medicine and Engineering, University of Pennsylvania School of Medicine, Philadelphia, PA 19104-4318, USA.

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http://www.jbc.org/content/281/13/8724.full.pdf
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http://www.jbc.org/content/early/2005/12/23/jbc.M511798200.f
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http://www.jbc.org/cgi/doi/10.1074/jbc.M511798200
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http://dx.doi.org/10.1074/jbc.M511798200DOI Listing
March 2006

Hormonal regulation of alveolarization: structure-function correlation.

Respir Res 2006 Mar 27;7:47. Epub 2006 Mar 27.

Division of Neonatology, Department of Pediatrics, Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.

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http://dx.doi.org/10.1186/1465-9921-7-47DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1448204PMC
March 2006

Surfactant composition and function in a primate model of infant chronic lung disease: effects of inhaled nitric oxide.

Pediatr Res 2006 Jan 2;59(1):157-62. Epub 2005 Dec 2.

Department of Pediatrics, Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, 19104, USA.

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http://dx.doi.org/10.1203/01.pdr.0000190664.69081.f1DOI Listing
January 2006

Expression and role of the hyaluronan receptor RHAMM in inflammation after bleomycin injury.

Am J Respir Cell Mol Biol 2005 Nov 21;33(5):447-54. Epub 2005 Jul 21.

Division of Neonatology, Department of Pediatrics, Children's Hospital of Philadelphia, PA 19104-4318, USA.

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http://dx.doi.org/10.1165/rcmb.2004-0333OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2715352PMC
November 2005

Alveolar surfactant protein D content modulates bleomycin-induced lung injury.

Am J Respir Crit Care Med 2005 Oct 30;172(7):869-77. Epub 2005 Jun 30.

Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, University of Pennsylvania School of Medicine, and Division of Neonatology, Children's Hospital of Philadelphia 19104, USA.

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http://dx.doi.org/10.1164/rccm.200505-767OCDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2718404PMC
October 2005

Comfort care of neonates at the end of life.

Neonatal Netw 2004 Sep-Oct;23(5):41-6

University of Pennsylvania, School of Nursing, Philadelphia 19124-6096, USA.

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http://dx.doi.org/10.1891/0730-0832.23.5.41DOI Listing
December 2004

Morphine enhances HIV infection of neonatal macrophages.

Pediatr Res 2003 Aug 7;54(2):282-8. Epub 2003 May 7.

Division of Immunologic and Infectious Diseases, The Children's Hospital of Philadelphia, 34th Street & Civic Center Boulevard, Philadelphia, PA 19104, U.S.A.

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http://dx.doi.org/10.1203/01.PDR.0000074973.83826.4CDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4035124PMC
August 2003

Heterogeneity of claudin expression by alveolar epithelial cells.

Am J Respir Cell Mol Biol 2003 Jul 23;29(1):62-70. Epub 2003 Jan 23.

Department of Physiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104-6085, USA.

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http://www.atsjournals.org/doi/abs/10.1165/rcmb.2002-0180OC
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http://dx.doi.org/10.1165/rcmb.2002-0180OCDOI Listing
July 2003

Midkine: a potential bridge between glucocorticoid and retinoid effects on lung vascular development.

Am J Respir Cell Mol Biol 2003 Jan;28(1):5-8

Division of Cardiology, Department of Medicine, Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA.

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http://www.atsjournals.org/doi/abs/10.1165/rcmb.F255
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http://dx.doi.org/10.1165/rcmb.F255DOI Listing
January 2003

Human surfactant protein B promoter in transgenic mice: temporal, spatial, and stimulus-responsive regulation.

Am J Physiol Lung Cell Mol Physiol 2002 Mar;282(3):L394-404

Division of Neonatology, Department of Pediatrics, The Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA.

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http://www.physiology.org/doi/10.1152/ajplung.00188.2001
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http://dx.doi.org/10.1152/ajplung.00188.2001DOI Listing
March 2002