♣ . Pediatric Allergy, Immunology and Pulmonology. 2011; 24(4): 225).
Pediatric Allergy, Immunology and Pulmonology
Congenital tuberculosis is rare inspite of tuberculosis being a common infection world wide.
Because of the nonspecific nature of the presenting signs and symptoms and fatal outcome in
absence of early therapy, the importance of early diagnosis is underscored. Young infants with
tuberculosis become infected after birth through exposure to family or household members with
contagious pulmonary disease. Routes of infection of the fetus before or during birth are
dissemination to fetus via the placenta, aspiration of infected amniotic fluid, and direct contact
with tuberculous cervicitis or endometritis.
We report a case from India of congenital tuberculosis in a 3 month old male infant who
presented with respiratory failure, hepatomegaly and diffuse infiltrates in the chest radiograph
that persisted despite empiric antibacterial therapy. No known exposure to tuberculosis by
history. Bronchoalveolar lavage culture yielded Mycobacterium tuberculosis. He was
successfully treated with quadruple anti-tuberculous medications reinforcing the potential good
outcomes with the correct diagnosis.
Indian Pediatrics. Vol 69, August 1998, 786 - 788.
Fibrodysplasia ossificans progressiva (FOP) also known as myositis ossificans progressiva is a rare inherited connective tissue disorder characterized by the heterotopic development of bone in areas of body where bone is not usually present such as ligaments, tendons and muscles(1).
The disease is extremely rare and fewer than hundred adult cases have been re- ported in USA and UK(2). We came across a typical case of FOP in a 21/2 years old child with extensive involvement. To the best of our knowledge, a case of full fledged "FOP" at 21/2 years of age has not been reported.
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