Publications by authors named "Rashid Ahmed"

201 Publications

Spontaneous dissection of bilateral internal carotid and vertebral arteries.

BMJ Case Rep 2021 Mar 29;14(3). Epub 2021 Mar 29.

Neurology, SUNY Upstate Medical University, Syracuse, New York, USA.

Spontaneous dissection of the major arteries of the neck is known to increase the risk of stroke or transient ischaemic attack in young and middle-aged adults. Most of the reported cases of arterial dissections in the neck involve one or both paired extracranial carotid or vertebral arteries. Spontaneous dissection of the bilateral internal carotid and vertebral arteries is extremely rare. We report a case of spontaneous bilateral internal carotid artery and vertebral artery dissection while using a prescribed pill for weight loss which contained amphetamine derivative. A review of literature is also provided.
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http://dx.doi.org/10.1136/bcr-2020-241173DOI Listing
March 2021

Yonder: Social distancing, point-of-care ultrasound, Irish GPs' educational needs, and retirement.

Authors:
Ahmed Rashid

Br J Gen Pract 2021 Apr 26;71(705):177. Epub 2021 Mar 26.

UCL Medical School, UCL, London. Email:

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http://dx.doi.org/10.3399/bjgp21X715517DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8007277PMC
April 2021

Stem cells based in vitro models: trends and prospects in biomaterials cytotoxicity studies.

Biomed Mater 2021 Mar 9;16(4):042003. Epub 2021 Mar 9.

Department of Bioinformatics and Biotechnology, Government College University Faisalabad, Faisalabad 38000 Punjab, Pakistan.

Advanced biomaterials are increasingly used for numerous medical applications from the delivery of cancer-targeted therapeutics to the treatment of cardiovascular diseases. The issues of foreign body reactions induced by biomaterials must be controlled for preventing treatment failure. Therefore, it is important to assess the biocompatibility and cytotoxicity of biomaterials on cell culture systems before proceeding to in vivo studies in animal models and subsequent clinical trials. Direct use of biomaterials on animals create technical challenges and ethical issues and therefore, the use of non-animal models such as stem cell cultures could be useful for determination of their safety. However, failure to recapitulate the complex in vivo microenvironment have largely restricted stem cell cultures for testing the cytotoxicity of biomaterials. Nevertheless, properties of stem cells such as their self-renewal and ability to differentiate into various cell lineages make them an ideal candidate for in vitro screening studies. Furthermore, the application of stem cells in biomaterials screening studies may overcome the challenges associated with the inability to develop a complex heterogeneous tissue using primary cells. Currently, embryonic stem cells, adult stem cells, and induced pluripotent stem cells are being used as in vitro preliminary biomaterials testing models with demonstrated advantages over mature primary cell or cell line based in vitro models. This review discusses the status and future directions of in vitro stem cell-based cultures and their derivatives such as spheroids and organoids for the screening of their safety before their application to animal models and human in translational research.
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http://dx.doi.org/10.1088/1748-605X/abe6d8DOI Listing
March 2021

Mitochondrial Myopathy, Encephalopathy, Lactic acidosis and Stroke-Like Episodes Syndrome Presenting With Anton-Babinski Syndrome and Concurrent Occipital Lobe Seizures.

Cureus 2021 Jan 25;13(1):e12908. Epub 2021 Jan 25.

Neurology, Upstate University Hospital, Syracuse, USA.

Mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes (MELAS) is a complex group of disorders with multisystem involvement that have a wide range of biochemical and genetic defects. The earliest symptoms of MELAS typically include easy fatigability, muscle weakness, encephalopathy with stroke-like episodes, recurrent headaches and seizures. The pathogenesis of stroke-like episodes manifesting as focal deficits like acute cortical blindness is not fully understood. We present an eight-year-old, right-handed boy with MELAS confirmed by the presence of pathogenic missense variant mutation (mt.3243A>G) presenting with acute intermittent reversible episodes of cortical blindness and Anton-Babinski Syndrome secondary to concurrent occipital lobe seizures captured during video electroencephalography (V-EEG) monitoring, in addition to the neuro-imaging which was not consistent with acute ischemic stroke. This case highlights the importance of the V-EEG monitoring besides clinical testing and radiographic correlation during acute cortical blindness episodes in MELAS as occipital lobe seizures could be a part of the symptomatology.
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http://dx.doi.org/10.7759/cureus.12908DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7904536PMC
January 2021

Rare PTA variant (Saltzman type IIIa) associated with multiple cerebral aneurysms.

BMJ Case Rep 2021 Mar 2;14(3). Epub 2021 Mar 2.

Neurosurgery, SUNY Upstate Medical University, Syracuse, New York, USA.

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http://dx.doi.org/10.1136/bcr-2020-241258DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7929836PMC
March 2021

Rare PTA variant (Saltzman type IIIa) associated with multiple cerebral aneurysms.

BMJ Case Rep 2021 Mar 2;14(3). Epub 2021 Mar 2.

Neurosurgery, SUNY Upstate Medical University, Syracuse, New York, USA.

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http://dx.doi.org/10.1136/bcr-2020-241258DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7929836PMC
March 2021

Stem cells basedmodels: Trends and prospects in biomaterials cytotoxicity studies.

Biomed Mater 2021 Feb 16. Epub 2021 Feb 16.

Department of Mechanical and Industrial Engineering, Qatar University, Qatar University, Doha, Ad Dawhah, 2713, QATAR.

Advanced biomaterials have produced a significant impact on healthcare by improving the quality of life of people with disabilities. Biomaterials are immensely used in tissue engineering, wound healing applications, and delivery of cancer targeted therapeutics. Biocompatibility and cytotoxicity screening of biomaterials on cell culture systems is the first step before their in vivo testing in animal models and subsequent clinical trials. Direct use of biomaterials on animals may create technical challenges as well as ethical concerns. In order to avoid the ethical concerns of animal use, many non-animal models such as stem cell cultures are being developed and utilized for testing their safety. However, due to several limitations including the inability to recapitulate the complex in vivo microenvironment, the application of stem cell cultures is limited. However, properties of stem cells such as their self-renewal and ability to differentiate into various cell lineages like hepatocytes, cardiomyocytes, and neural cells make them an ideal candidates for in vitro screening studies. Furthermore, the application of stem cells may overcome the challenges associated with the inability to develop a complex heterogeneous tissue using primary cells. Currently, Embryonic Stem Cells (ESCs), Adult Stem Cells (ASCs), and Induced Pluripotent Stem Cells (iPSCs) are being used as in vitro preliminary biomaterials testing models with demonstrated advantages over mature primary cell or cell line based in vitro models. This review discusses the current status and future directions of in vitro stem cell-based cultures and their derivatives such as spheroids and organoids for the screening of their safety before their application to animal models and human in translational research.
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http://dx.doi.org/10.1088/1748-605X/abe6d8DOI Listing
February 2021

Changing professional behaviours: mixed methods study utilising psychological theories to evaluate an educational programme for UK medical doctors.

BMC Med Educ 2021 Feb 5;21(1):92. Epub 2021 Feb 5.

Research Department of Medical Education, UCL Medical School, Royal Free Hospital, Room GF/664, London, NW3 2PF, UK.

Background: The Theory of Planned Behaviour (TPB) has been proposed as a useful framework to investigate professional behaviour, however, was not yet applied to the evaluation of an educational intervention. This study will address this gap by utilising the TPB to evaluate the effectiveness of an education programme delivered by the professional regulator for UK doctors in enhancing three professional behaviours: raising concerns, engaging in reflective practice, and use of regulator confidentiality guidance.

Methods: This is a comprehensive mixed methods study combining qualitative (interviews) and quantitative (quasi-experiment) data. Intervention participants were asked to complete a survey measuring the variables in the TPB (attitudes, subjective norms, perceived behavioural control, and intention) for the three professional behaviours before, immediately post, and 3-months later following the education programme. Ninety-four doctors completed the survey pre/post intervention and 38 at all three times. One hundred and eleven doctors from the same hospital trust who did not take part in the intervention completed the survey at two time points and formed the control group. Forty-two interviews were conducted with intervention participants.

Results: The quantitative study revealed that the educational intervention significantly improved attitudes (raising concerns, using confidentiality guidance), subjective norms (raising concerns, reflective practice, using confidentiality guidance), perceived control (raising concerns, using confidentiality guidance), and intentions (using confidentiality guidance) (Group and Time interaction; Fs ≥ 3.996, ps ≤ .047, ηp ≥ .020). Non-UK graduate doctors' subjective norms towards raising concerns and confidentiality guidance increased significantly after the intervention (Fs ≤ 6.602, ps ≥ .011, ηp = .032 F = 6.602, p = .011, ηp = .032), but not UK graduates (p > .05). Interviews revealed that doctors had positive views about professional behaviours but also mentioned numerous barriers to actually engage in more complex, context dependent behaviours.

Conclusions: This study demonstrates that an educational intervention was successful in improving the TPB variables of three professional behaviours. It also revealed that teaching professionalism does not happen in isolation and, therefore, personal and contextual factors are crucial to consider. To change complex professional behaviours, barriers at all levels i.e., personal, organisational and system, should be addressed.
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http://dx.doi.org/10.1186/s12909-021-02510-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7866444PMC
February 2021

Yonder: COVID non-compliance, antidepressant withdrawal, probiotics, and GPs in China.

Authors:
Ahmed Rashid

Br J Gen Pract 2021 28;71(703):76. Epub 2021 Jan 28.

UCL Medical School, UCL, London. Email:

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http://dx.doi.org/10.3399/bjgp21X714785DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7846372PMC
January 2021

Dural arteriovenous fistula and arteriovenous malformation presenting as trigeminal neuralgia.

BMJ Case Rep 2021 Jan 7;14(1). Epub 2021 Jan 7.

Neurosurgery, SUNY Upstate Medical University, Syracuse, New York, USA.

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http://dx.doi.org/10.1136/bcr-2020-240483DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7797261PMC
January 2021

Yonder: Locum doctors, testicular pain, chaplaincy services, and mumsnet.

Authors:
Ahmed Rashid

Br J Gen Pract 2021 01 28;71(702):31. Epub 2020 Dec 28.

GP and Clinical Associate Professor, UCL Medical School, UCL, London. Email:

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http://dx.doi.org/10.3399/bjgp21X714521DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7759359PMC
January 2021

Accreditation drives teaching: evidence-based medicine and medical education standards.

BMJ Evid Based Med 2020 Dec 24. Epub 2020 Dec 24.

Johns Hopkins Bayview Medical Center, Baltimore, Maryland, USA.

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http://dx.doi.org/10.1136/bmjebm-2020-111491DOI Listing
December 2020

Bone marrow mesenchymal stem cells preconditioned with nitric oxide releasing chitosan/PVA hydrogel attenuate diabetic wound healing in rabbits.

Biomed Mater 2020 Oct 19. Epub 2020 Oct 19.

Department of Mechanical and Industrial Engineering, Qatar University, Doha, Doha, QATAR.

Impaired diabetic wounds are one of the major pathophysiological complications caused by persistent microbial infections, prolonged inflammation, and insufficient angiogenic responses. Here, we report the development of nitric oxide (NO) releasing S-nitroso-N-acetyl-pencillamine (SNAP) loaded chitosan/polyvinyl alcohol hydrogel and its efficacy in enhancing wound healing potential of bone marrow mesenchymal stem cells in diabetic wounds. NO-releasing hydrogels significantly increased the cell viability and cell proliferation of hydrogen peroxide (H2O2) pretreated bone marrow stem cells (BMSCs) depicting its cytoprotective activity which was further confirmed by a manifold increase in the gene expression of B-cell lymphoma 2 (Bcl-2), stromal cell-derived factor 1alpha (SDF-1α), proliferating cell nuclear antigen (PCNA) and vascular endothelial growth factor (VEGF). Furthermore, the SNAP loaded hydrogel showed continuous cell proliferating activity for six days due to the slow release of NO from hydrogel. Wound healing studies on diabetes-induced rabbits showed that the application of SNAP preconditioned BMSCs and NO-releasing hydrogels significantly speed up the healing process compared to the control group. The wound healing potential of BMSCs plus NO-releasing hydrogel was further validated by improved collagen deposition and epithelial layer formation by histopathological examinations as well as upregulation of VEGF and SDF-1α biomarkers through gene expression analysis. These results exhibited that the application of BMSCs and NO-releasing hydrogel can help in faster regeneration of damaged tissues. Therefore, BMSCs plus NO-releasing hydrogels can be very useful for the treatment of diabetic wounds.
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http://dx.doi.org/10.1088/1748-605X/abc28bDOI Listing
October 2020

Yonder: Rheumatoid feet, paternal mental health, sciatica, and good family nurses.

Authors:
Ahmed Rashid

Br J Gen Pract 2020 10 1;70(699):505. Epub 2020 Oct 1.

GP and Principal Clinical Teaching Fellow, UCL Medical School, UCL, London. Email:

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http://dx.doi.org/10.3399/bjgp20X712889DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7518910PMC
October 2020

United States County-level COVID-19 Death Rates and Case Fatality Rates Vary by Region and Urban Status.

Healthcare (Basel) 2020 Sep 9;8(3). Epub 2020 Sep 9.

Southend Medical and Walk-in Clinic, Winnipeg, MB R2M 5G8, Canada.

COVID-19 is a global pandemic with uncertain death rates. We examined county-level population morality rates (per 100,000) and case fatality rates by US region and rural-urban classification, while controlling for demographic, socioeconomic, and hospital variables. We found that population mortality rates and case fatality rates were significantly different across region, rural-urban classification, and their interaction. All significant comparisons had < 0.001. Northeast counties had the highest population mortality rates (27.4) but had similar case fatality rates (5.9%) compared to other regions except the Southeast, which had significantly lower rates (4.1%). Population mortality rates were highest in urban counties but conversely, case fatality rates were highest in rural counties. Death rates in the Northeast were driven by urban areas (e.g., small, East Coast states), while case fatality rates tended to be highest in the most rural counties for all regions, especially the Southwest. However, on further inspection, high case fatality rate percentages in the Southwest, as well as in overall US counties, were driven by a low case number. This makes it hard to distinguish genuinely higher mortality or an artifact of a small sample size. In summary, coronavirus deaths are not homogenous across the United States but instead vary by region and population and highlight the importance of fine-scale analysis.
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http://dx.doi.org/10.3390/healthcare8030330DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7551952PMC
September 2020

Enhanced Thermostability and Enzymatic Activity of Cel6A Variants from by Empirical Domain Engineering (Short Title: Domain Engineering of Cel6A).

Biology (Basel) 2020 Aug 7;9(8). Epub 2020 Aug 7.

Department of Pharmaceutical and Pharmacological Sciences, Rega Institute for Medical Research, Medicinal Chemistry, University of Leuven, B-3000 Leuven, Belgium.

Cellulases are a set of lignocellulolytic enzymes, capable of producing eco-friendly low-cost renewable bioethanol. However, low stability and hydrolytic activity limit their wide-scale applicability at the industrial scale. In this work, we report the domain engineering of endoglucanase (Cel6A) of to improve their catalytic activity and thermal stability. Later, enzymatic activity and thermostability of the most efficient variant named as Cel6A.CBC was analyzed by molecular dynamics simulations. This variant demonstrated profound activity against soluble and insoluble cellulosic substrates like filter paper, alkali-treated bagasse, regenerated amorphous cellulose (RAC), and bacterial microcrystalline cellulose. The variant Cel6A.CBC showed the highest catalysis of carboxymethyl cellulose (CMC) and other related insoluble substrates at a pH of 6.0 and a temperature of 60 °C. Furthermore, a sound rationale was observed between experimental findings and molecular modeling of Cel6A.CBC which revealed thermostability of Cel6A.CBC at 26.85, 60.85, and 74.85 °C as well as structural flexibility at 126.85 °C. Therefore, a thermostable derivative of Cel6A engineered in the present work has enhanced biological performance and can be a useful construct for the mass production of bioethanol from plant biomass.
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http://dx.doi.org/10.3390/biology9080214DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7464639PMC
August 2020

Loop-Mediated Isothermal Amplification (LAMP): A Rapid, Sensitive, Specific, and Cost-Effective Point-of-Care Test for Coronaviruses in the Context of COVID-19 Pandemic.

Biology (Basel) 2020 07 22;9(8). Epub 2020 Jul 22.

Interventional Regenerative Medicine and Imaging Laboratory, Department of Radiology, School of Medicine, Stanford University, Palo Alto, CA 94304, USA.

The rampant spread of COVID-19 and the worldwide prevalence of infected cases demand a rapid, simple, and cost-effective Point of Care Test (PoCT) for the accurate diagnosis of this pandemic. The most common molecular tests approved by regulatory bodies across the world for COVID-19 diagnosis are based on Polymerase Chain Reaction (PCR). While PCR-based tests are highly sensitive, specific, and remarkably reliable, they have many limitations ranging from the requirement of sophisticated laboratories, need of skilled personnel, use of complex protocol, long wait times for results, and an overall high cost per test. These limitations have inspired researchers to search for alternative diagnostic methods that are fast, economical, and executable in low-resource laboratory settings. The discovery of Loop-mediated isothermal Amplification (LAMP) has provided a reliable substitute platform for the accurate detection of low copy number nucleic acids in the diagnosis of several viral diseases, including epidemics like Severe Acute Respiratory Syndrome (SARS) and Middle East Respiratory Syndrome (MERS). At present, a cocktail of LAMP assay reagents along with reverse transcriptase enzyme (Reverse Transcription LAMP, RT-LAMP) can be a robust solution for the rapid and cost-effective diagnosis for COVID-19, particularly in developing, and low-income countries. In summary, the development of RT-LAMP based diagnostic tools in a paper/strip format or the integration of this method into a microfluidic platform such as a Lab-on-a-chip may revolutionize the concept of PoCT for COVID-19 diagnosis. This review discusses the principle, technology and past research underpinning the success for using this method for diagnosing MERS and SARS, in addition to ongoing research, and the prominent prospect of RT-LAMP in the context of COVID-19 diagnosis.
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http://dx.doi.org/10.3390/biology9080182DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7464797PMC
July 2020

Yonder: Vitamin D screening, startups, social distancing, and world leaders on Twitter.

Authors:
Ahmed Rashid

Br J Gen Pract 2020 07 25;70(696):348. Epub 2020 Jun 25.

UCL Medical School, UCL, London. Email:

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http://dx.doi.org/10.3399/bjgp20X710573DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7319693PMC
July 2020

Yonder: Domestic violence, norovirus, palliative care referrals, and quarantine adherence.

Authors:
Ahmed Rashid

Br J Gen Pract 2020 Jun 28;70(695):298. Epub 2020 May 28.

UCL Medical School, UCL, London. Email:

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http://dx.doi.org/10.3399/bjgp20X710249DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7241916PMC
June 2020

Yonder: Oncogeriatrics, binge eating in black women, dissection, and podcasts.

Authors:
Ahmed Rashid

Br J Gen Pract 2020 05 30;70(694):246. Epub 2020 Apr 30.

UCL Medical School, UCL, London. Email:

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http://dx.doi.org/10.3399/bjgp20X709697DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7194755PMC
May 2020

The first clusters of Middle East respiratory syndrome coronavirus in Oman: Time to act.

J Infect Public Health 2020 May 16;13(5):679-686. Epub 2020 Apr 16.

Royal Hospital, Ministry of Health, Oman. Electronic address:

Introduction: Middle East respiratory syndrome coronavirus (MERS-CoV), is an emerging infectious disease of growing global importance. This review describes the latest MERS-CoV clusters and the first cases of nosocomial transmission within health care facilities in Oman. We have highlighted lessons learned and proposed steps to prevent healthcare-associated infections.

Methods: A descriptive analysis of MERS-CoV cases was conducted between January 23 and February 16, 2019. The data from officials and other published sources used.

Results: Thirteen laboratory-confirmed cases of MERS-CoV were reported from three simultaneous clusters from two governorates without an epidemiological link between the clusters. Two clusters were reported from North Al Batinah Governorate, with nine cases (69%) and 1 cluster from South Ash Sharqiyah Governorate with four cases (31%). In total, four deaths were reported (case fatality rate 31%). Four cases (31%) reported were household contacts from the first cluster, 3 (23%) were nosocomial transmission in health care facilities (two for first and one from the second cluster) and 7 (54%) were community-acquired cases.

Conclusions: The first local clusters of MERS-CoV reported with evidence suggestive of healthcare and household-associated transmission. Early diagnosis and strict implementation of infection control measures remain fundamental in preventing and managing MERS-CoV infection.
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http://dx.doi.org/10.1016/j.jiph.2020.03.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7162632PMC
May 2020

Electrospun chitosan membranes containing bioactive and therapeutic agents for enhanced wound healing.

Int J Biol Macromol 2020 Aug 27;156:153-170. Epub 2020 Mar 27.

Department of Mechanical and Industrial Engineering, College of Engineering, Qatar University, Doha 2713, Qatar; Biomedical Research Centre, Qatar University, Doha 2713, Qatar. Electronic address:

Electrospinning is one of the most promising techniques for generating porous, nonwoven, and submicron fiber-based membranes for various applications such as catalysis, sensing, tissue engineering and wound healing. Wide range of biopolymers including chitosan can be used to generate submicron fibrous membranes. Owing to the extra cellular matrix (ECM) mimicking property, exudate uptake capacity, biocompatibility, antibacterial activity and biodegradability, electrospun membranes based on chitosan loaded with biologically active agents can play important role in wound healing applications. In order to improve the mechanical stability, degradation, antimicrobial property, vascularization potential and wound healing capacity, various active components such as other polymers, therapeutic agents, nanoparticles and biomolecules were introduced. Approaches such as coaxial electrospinning with other polymers have also been tried to improve the properties of chitosan membranes. To improve the mechanical stability under in vivo conditions, various crosslinking strategies ranging from physical, chemical and biological approaches were also tried by researchers. Electrospun chitosan meshes have also been designed in a highly specialized manner with specific functionalities to deal with the challenging wound environment of diabetic and burn wounds. This review provides a detailed overview of electrospun chitosan-based membranes containing various bioactive and therapeutic agents in the perspective of wound healing and skin regeneration.
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http://dx.doi.org/10.1016/j.ijbiomac.2020.03.207DOI Listing
August 2020

Yonder: Gestational diabetes, older drinkers, spirituality, and dance therapy.

Authors:
Ahmed Rashid

Br J Gen Pract 2020 04 26;70(693):188. Epub 2020 Mar 26.

UCL Medical School, UCL, London. Email:

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http://dx.doi.org/10.3399/bjgp20X709133DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7098494PMC
April 2020

A High-Performing Plasma Metabolite Panel for Early-Stage Lung Cancer Detection.

Cancers (Basel) 2020 Mar 7;12(3). Epub 2020 Mar 7.

Department of Biological Sciences, University of Alberta, Edmonton, AB T6G 2E8, Canada.

The objective of this research is to use metabolomic techniques to discover and validate plasma metabolite biomarkers for the diagnosis of early-stage non-small cell lung cancer (NSCLC). The study included plasma samples from 156 patients with biopsy-confirmed NSCLC along with age and gender-matched plasma samples from 60 healthy controls. A fully quantitative targeted mass spectrometry (MS) analysis (targeting 138 metabolites) was performed on all samples. The sample set was split into a discovery set and validation set. Metabolite concentration data, clinical data, and smoking history were used to determine optimal sets of biomarkers and optimal regression models for identifying different stages of NSCLC using the discovery sets. The same biomarkers and regression models were used and assessed on the validation models. Univariate and multivariate statistical analysis identified β-hydroxybutyric acid, LysoPC 20:3, PC ae C40:6, citric acid, and fumaric acid as being significantly different between healthy controls and stage I/II NSCLC. Robust predictive models with areas under the curve (AUC) > 0.9 were developed and validated using these metabolites and other, easily measured clinical data for detecting different stages of NSCLC. This study successfully identified and validated a simple, high-performing, metabolite-based test for detecting early stage (I/II) NSCLC patients in plasma. While promising, further validation on larger and more diverse cohorts is still required.
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http://dx.doi.org/10.3390/cancers12030622DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7139410PMC
March 2020

Yonder: Colonoscopy, bone health, risk communication, and task shifting.

Authors:
Ahmed Rashid

Br J Gen Pract 2020 Mar 27;70(692):126. Epub 2020 Feb 27.

UCL Medical School, UCL, London. Email:

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http://dx.doi.org/10.3399/bjgp20X708581DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7038851PMC
March 2020