Publications by authors named "Rasha Atlasi"

25 Publications

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Visualization of knowledge flow in interpersonal scientific collaboration network endocrinology and metabolism research institute.

J Diabetes Metab Disord 2021 Jun 1;20(1):815-823. Epub 2020 Oct 1.

Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.

Purpose: Research collaborations can help to increase scientific productivity. The purpose of the present study was to draw up the knowledge flow network of the Endocrinology and Metabolism Research Institute (EMRI) affiliated to Tehran University of Medical Sciences.

Methods: The present study is a descriptive cross-sectional study on the publications of the EMRI. Web of Science Core collection databases were searched for the EMRI publications between 2002 to November 2019. Besides, publications were classified and visualized based on authorships (institutes and country of affiliation), and keywords (co-occurrence and trend). Scientometric methods including VOSviewer and HistCite were used for descriptive statistics and data analysis.

Results: Total citations to the records were 47,528 and papers were published in 916 journals. The annual growth rate of publications and the citation was 14.2% and 18.9%, respectively. A total of 9466 authors from 136 countries collaborated in the publications. The co-authorship patterns showed that the average co-authorship and collaboration coefficient was 3.3 and 0.19.

Conclusion: Knowledge flow between EMRI researchers with international collaborations, engagement with leading countries, and interdisciplinary collaborations have an increasing trend. To develop a full picture of co-authorship, using social network analysis indicators are suggested for future studies.
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http://dx.doi.org/10.1007/s40200-020-00644-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8212232PMC
June 2021

The effects of dietary/herbal supplements and the serum levels of micronutrients on the healing of diabetic foot ulcers in animal and human models: a systematic review.

J Diabetes Metab Disord 2021 Jun 26;20(1):973-988. Epub 2021 May 26.

Diabetes Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.

Purpose: Diabetic Foot Ulcer (DFU) is one of the common and serious complications in patients with Diabetes Mellitus (DM) worldwide. Given the considerable tendency of patients suffering from DFU to use the complementary therapies, the objectives of this study were to: (i) summarize the effects of dietary and herbal supplements on DFU characteristics and metabolic parameters in both animal models and clinical trials, and (ii) evaluate any links between the serum levels of micronutrients and DFU in observational studies.

Methods: A systematic search in five electronic databases including PubMed/Medline, Scopus, Web of Science, Embase, and Cochrane Library was conducted to find relevant English language published from 1990 until 31 December 2018.

Results: Of a total of 8603 studies, 30 eligible papers including animal studies ( = 15), clinical trials ( = 7), and observational works ( = 8) were included in the systematic review. We found that some dietary/herbal supplements and micronutrients had positive effects on the wound healing. However, limited evidence is existed. Also, lower serum levels of vitamin D, C, vitamin E, and selenium in patients with DFU were likely to increase the risk of DFU, leading to impaired wound healing.

Conclusion: Findings suggested that some dietary and herbal supplements such as Vitamin D, Magnesium, Vitamin E, Probiotic, Zinc, and Pycnogenol would be effective on wound healing of DFUs. However, further high-quality randomized controlled clinical trials and prospective cohort studies are needed to clarify the roles of micronutrients and other dietary and herbal supplements on the progress and treatment of DFU.
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http://dx.doi.org/10.1007/s40200-021-00793-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8212333PMC
June 2021

Evidence Gap and Knowledge Map of Physical Activity Research in Diabetes in Iran: A Scoping Review.

Int J Endocrinol Metab 2021 Apr 27;19(2):e110636. Epub 2021 Apr 27.

Diabetes Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.

Context: The important role of physical activity in the prevention and management of diabetes necessitates a review of current research to shed light on gaps in national diabetes guidelines.

Evidence Acquisition: This scoping review was part of the Iran Diabetes Research Roadmap (IDRR) study. A systematic search was used based on the Arksey and O'Malley method consisting of six steps. The descriptive analysis was done with SPSS software. Additionally, VOS veiwer software was used to draw the knowledge map of the included studies.

Results: There were 169 articles included from the beginning of 2015 to the end of 2019 in Iran. Aerobic and resistance exercises were types of physical activity with more number of articles. Most of the included clinical studies were randomized clinical trials and had a level of evidence two. Also, there was more interest in outcomes such as glycemic control and insulin sensitivity, metabolic syndrome, metabolism, and cardiovascular health. The network of co-authorship was drawn, and "controlled study", "male", and "rat" were the most frequent keywords.

Conclusions: The number of Iranian diabetes researchers on physical activity is increasing, and the majority of clinical studies had a high level of evidence. With maintaining previous interests and investigations, there should be more emphasis on research in elderly and children age groups as evidence gap in Iran. Also, longitudinal cohort studies should be highlighted and Iranian researchers should be encouraged to participate in new topics of research worldwide.
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http://dx.doi.org/10.5812/ijem.110636DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8198613PMC
April 2021

Innovative human resource management strategies during the COVID-19 pandemic: A systematic narrative review approach.

Heliyon 2021 Jun 7;7(6):e07233. Epub 2021 Jun 7.

Department of Health Information Management, School of Paramedical Sciences, Ardabil University of Medical Sciences, Ardabil, Iran.

Background: The spread of COVID-19 creates disruption, uncertainty, complexity, and ambiguity in all organizations. People are the primary asset of any organization and help achieve their goals. Accordingly, to manage human resources sustainably, the organizational strategy review is an appropriate retort.

Objective: The purpose of this comprehensive review study is to identify unknown challenges, strategies, and unusual decisions related to human resource management other than clinical organizations during the COVID-19 pandemic.

Methods: The study applied a narrative review approach dissection based on organizations' human resource management strategies to combat the COVID-19 impacts. The review study conducted published literature research through the electronic databases at Web of Science, PubMed, Scopus, PsycINFO, and LISTA. The study extracted 1281 articles from the mentioned databases from November 2021 to the first quarter of 2021. This study reviewed selected papers, included 15 relevant articles, and removed duplicates according to inclusion and exclusion criteria. Finally, the study developed a conceptual framework of human resource management strategies based on the literature findings to fight against the COVID-19 pandemic.

Results: The COVID-19 pandemic posed numerous adverse consequences, such as economic shock, global health crisis, change in social behaviors, and challenges at the organization level to continue business operations. Besides, the strategies included flexibility, strengthening internal efficiency, talent acquisition, and making innovative changes based on organizational assessment and needs for smooth business activities.

Conclusion: The appropriate human resource management strategies implementations would increase employees' mental well-being, satisfaction, productivity, motivation, and health safety at the workplace.
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http://dx.doi.org/10.1016/j.heliyon.2021.e07233DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8183111PMC
June 2021

Co-authorship network analysis of Iranian researchers on osteoporosis.

Arch Osteoporos 2021 04 20;16(1):74. Epub 2021 Apr 20.

Osteoporosis Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, No. 10, Jalale-al-Ahmad Ave., Tehran, Iran.

Our purpose was to investigate the co-authorship network of Iranian researchers in the field of osteoporosis. We used 1328 documents retrieved from databases of PubMed, Scopus, and Web of Science in the analysis. The network had 183 authors in 13 clusters, low cohesion, and slow information flow between its members.

Purpose: This study aims to investigate the pattern and characteristics of cooperation between Iranian researchers in the field of osteoporosis through the co-authorship social network analysis.

Methods: All papers on osteoporosis with at least one Iranian author were retrieved from medical databases of PubMed, Scopus, and Web of Science from 2009 to 2019. After the removal of duplicates, the title and abstract of the papers were reviewed by two independent reviewers, and screening was performed according to the inclusion and exclusion criteria. The data were entered into the BibExecl software, and the different spelling forms in the author names were manually merged. The authors' co-occurrence matrix was then developed and entered into the UCINET software and the cohesion indexes (density, diameter, and average distance) and centrality indexes (degree, betweenness, closeness, and eigenvector) for the co-authorship network were estimated. The institutions and countries of the authors of the entered papers were also used in the network analysis and their socio-graphs were drawn.

Results: We used 1328 documents in the analysis. The co-authorship network was constructed only for authors with at least 5 papers. The network had 183 nodes (authors) in 13 clusters. Its density was 0.063 and its number of components was 2. The large component encompassed 95.6% and the small component 4.4% of authors. The average distance in the main component of the network was 3 and its diameter was 6. Larijani B was ranked first in the network in terms of degree, betweenness, closeness, and eigenvector centrality. In terms of the contribution of organizations in osteoporosis publications, Tehran University of Medical Sciences (with 35.5% of papers published in WoS database), Shahid Beheshti University of Medical Sciences (14.7%), and Shiraz University of Medical Sciences (9.3%) retained in the first to third place, respectively. In papers published on the WoS, most Iranian authors have collaborated with authors from the USA, Belgium, Canada, and the UK respectively.

Conclusion: The co-authorship network had low cohesion with slow information flow between its members. The collaboration with young researchers by the network's active, efficient, and broker authors will lead to the maintenance and development of the network.
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http://dx.doi.org/10.1007/s11657-021-00914-9DOI Listing
April 2021

Research gaps in Ramadan fasting studies in health and disease.

Diabetes Metab Syndr 2021 May-Jun;15(3):831-835. Epub 2021 Apr 15.

Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran. Electronic address:

Background And Aim: Ramadan fasting is a religious fasting of Muslims and has many effects on health and disease. This study aim was to analyze Ramadan fasting research output during the past five years and identify research gaps in this field.

Materials And Methods: A systematic search was performed in Web of Science, pubmed, Scopus, EMBASE and Cochrane databases by appropriate keywords. Documents published between January 2015 and January 2020 with English language were included. After removing duplicates, remained documents were screened and classified.

Results: Finally, after screening, 393 documents remained and were classified. Of these documents, 53 were review article and 338 original articles. More than 96% of studies were clinical study while basic science studies were too limited. Among the study topics, diabetes mellitus with 31% was the most common topic followed by metabolic disorders and nutrition, respectively.

Conclusion: Ramadan fasting is an important religious issue that needs more attention. Research should be directed to clinical and basic studies in different health and disease conditions other than nutrition and metabolic disorders.
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http://dx.doi.org/10.1016/j.dsx.2021.04.009DOI Listing
April 2021

The effectiveness of different types of motorcycle helmets - A scoping review.

Accid Anal Prev 2021 May 6;154:106065. Epub 2021 Mar 6.

Sina Trauma and Surgery Research Center, Tehran University of Medical Sciences, Tehran, Iran; Brain and Spinal Cord Injury Research Center, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran; Department of Neurosurgery, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran; Universal Scientific Education and Research Network (USERN), Tehran, Iran; Institute of Biochemistry and Biophysics, University of Tehran, Tehran, Iran; University of Toronto, Toronto, Canada. Electronic address:

Background: Protective helmets may reduce the risk of death and head injury in motorcycle collisions. However, there remains a large gap in knowledge regarding the effectiveness of different types of helmets in preventing injuries.

Objective: To explore and evaluate the effectiveness of different types of motorcycle helmets; that is the association between different helmet types and the incidence and severity of head, neck, and facial injuries among motorcyclists. Also, to explore the effect of different helmet types on riders.

Methods: A systematic search of different scientific databases was conducted from 1965 to April 2019. A scoping review was performed on the included articles. Eligible articles were included regarding defined criteria. Study characteristics, helmet types, fixation status, retention system, the prevention of injury or reduction of its severity were extracted.

Results: A total of 137 studies were included. There was very limited evidence for the better protection of full-face helmets from head and facial injury compared to open-face and half-coverage helmets. There was however scarce evidence for the superiority of a certain helmet type over others in terms of protection from neck injury. The retention system and the fixation status of helmets were two important factors affecting the risk of head and brain injury in motorcyclists. Helmets could also affect and limit the riders in terms of vision, hearing, and ventilation. Multiple solutions have been discussed to mitigate these effects.

Conclusion: Full-face helmets may protect head and face in motorcycle riders more than open-face and half-coverage helmets, but there is not enough evidence for better neck protection among these three helmet types. Helmets can affect the rider's vision, hearing, and ventilation. When designing a helmet, all of these factors should be taken into account.
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http://dx.doi.org/10.1016/j.aap.2021.106065DOI Listing
May 2021

Scientometric analyzing the output of researchers and organizations on COVID-19 for better conducting the scientific efforts: with a glance to endocrinology.

J Diabetes Metab Disord 2021 Jan 29:1-12. Epub 2021 Jan 29.

Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.

Purpose: As COVID-19 spreads rapidly and could affect the people and also lead to their death, especially individuals with as diabetes, the research community is also active in publishing novel research about it. Analyzing scientific outputs in this topic can represent an overview of publications. For this purpose, this study was conducted to determine status of publishing research works related to COVID-19 and analyzing the all documents published and indexed in Web of Science database and illustrate the co-occurrence and co-authority of hot papers in this documents.

Methodology: Our search strategy was based on using the related key terms including COVID-19, coronavirus, SARS2, etc., to find out all the published scientific works related to coronavirus disease indexed in web of science (WoS) in 2020. We then extracted the all hot papers and especially hot papers in endocrinology category and analyzed them. The data saved and imported in VOSviewer and ScientoPy programs for analysis and illustration of our data. We have shown our analysis in the tables, figures and maps.

Results: Totally, 56,402 records and 309 hot papers were retrieved. 3 of these hot papers were in endocrinology category. The most common type of publication was original papers followed by editorial papers in the second rank. The country with the most published documents was the USA followed by China. The journals of "British Medical Journal" and "Journal of Medical Virology" were ranked as the first and second sources, respectively. The "Harvard University" was the top organization with high proportion of scientific publications and "the Lancet" was the top-ranked journal that published highly-cited papers.

Conclusion: The literature on COVID-19 is increasing with a high and fast growth. In this regard, there is a need to evaluate these publications once in a while and their results should be published to use this information for more effective management of future research works with emphasizes on the gaps of researches and more citable documents and allocation of budgets on more needed research and don't carry out the duplicates research. This would be helpful for prevention, control, and treatment of COVID-19 that is now among the most common topics in the world.
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http://dx.doi.org/10.1007/s40200-020-00718-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7843242PMC
January 2021

Trend of nutrition research in endocrine disorders, gaps, and future plans: a collection of experiences of an endocrinology research institute.

J Diabetes Metab Disord 2021 Jan 22:1-8. Epub 2021 Jan 22.

Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.

Background: Nutrition plays a pivotal role in the prevention and treatment of endocrine disorders. The aim of this study was to provide a window in order to display the 25-year activities of Endocrinology & Metabolism Research Institute (EMRI), and the gaps and future plans in the field of nutrition and endocrine disorders.

Methods: To collect papers affiliated to the EMRI in field of nutrition from the inception to December 1st 2019, the electronic databases including PubMed/Medline, Web of Science, and Scopus were searched. Publications in English and Persian languages were included. Scientific Landscapes (VOS viewer) software version 1.6.13 was used to provide bibliometric maps.

Results: Of 4082 studies identified in the initial search, 319 relevant papers were included. They contributed systematic review and meta-analysis/review ( = 76), clinical trials ( = 58), cross-sectional ( = 171), case-control studies ( = 11), and animal studies ( = 3). Accordingly, most nutrition studies were dedicated to the level of evidence III (cross-sectional studies: 53.60%) followed by systematic review studies (23.82%) with the level of evidence I. There was also an increasing trend in the nutrition studies through years, with a peak in 2019.

Conclusion: An increasing trend in the publications related to nutrition science is observed at EMRI. However, nutrition research and publications can grow further through expanding collaborations with other fields related to endocrine. Given nutritional assessments in national projects and focusing on the identification of preventive nutritional strategies, considering the situations of our society can be helpful to make nutritional findings more practical.
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http://dx.doi.org/10.1007/s40200-020-00707-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7821177PMC
January 2021

Macrophage migration inhibitory factor as a therapeutic target after traumatic spinal cord injury: a systematic review.

Eur Spine J 2021 06 24;30(6):1474-1494. Epub 2021 Jan 24.

Sina Trauma and Surgery Research Center, Sina Hospital, Tehran University of Medical Sciences, Hassan-Abad Square, Imam Khomeini Ave, 11365-3876, Tehran, Iran.

Purpose: Macrophages play an important role in mediating damage after Spinal cord injury (SCI) by secreting macrophage migration inhibitory factor (MMIF) as a secondary injury mediator. We aimed to systematically review the role of MMIF as a therapeutic target after traumatic SCI.

Methods: Our systematic review has been performed according to the PRISMA 2009 Checklist. A systematic search in the scientific databases was carried out for studies published before 20 February 2019 from major databases. Two researchers independently screened titles. The risk of bias of eligible articles was assessed, and data were extracted. Finally, we systematically analyzed and interpreted related data.

Results: 785 papers were selected for the title and abstract screening. 12 papers were included for data extraction. Eight animal studies were of high quality and the remaining two were of medium quality. One of the two human studies was of poor quality and the other was of fair quality. MMIF as a pro-inflammatory mediator can cause increased susceptibility to glutamate-related neurotoxicity, increased nitrite production, increased ERK activation, and increased COX2/PGE2 signaling pathway activation and subsequent stimulation of CCL5-related chemotaxis. Two human studies and six animal studies demonstrated that MMIF level increases after SCI. MMIF inhibition might be a potential therapeutic target in SCI by multiple different mechanisms (6/12 studies).

Conclusion: Most animal studies demonstrate significant neurologic improvement after administration of MMIF inhibitors, but these inhibitors have not been studied in humans yet. Further clinical trials are need to further understand MMIF inhibitor utility in acute or chronic SCI.

Level Of Evidence I: Diagnostic: individual cross-sectional studies with the consistently applied reference standard and blinding.
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http://dx.doi.org/10.1007/s00586-021-06718-2DOI Listing
June 2021

A systematic review on thyroid organoid models: time-trend and its achievements.

Am J Physiol Endocrinol Metab 2021 03 11;320(3):E581-E590. Epub 2021 Jan 11.

Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.

Current in vitro models have played important roles in improving knowledge and understanding of cellular and molecular biology, but cannot exactly recapitulate the physiology of human tissues such as thyroid. In this article, we conducted a systematic review to present scientific and methodological time-trends of the reconstruction and generation of 3 D functional thyroid follicles and organoids for thyroid research in health and disease. "Web of Science (ISI)", "Scopus", "Embase", "Cochrane Library", and "PubMed" were systematically searched for papers published since 1950 to May 2020 in English language, using the predefined keywords. 212 articles were reviewed and finally 28 papers that met the inclusion and exclusion criteria were selected. Among the evidence for the examination of 3 D cell culture methods in thyroid research, there were only a few studies related to the organoid technology and its potential applications in understanding morphological, histological, and physiological characteristics of the thyroid gland and reconstructing this tissue. Besides, there was no study using organoids to investigate the tumorigenesis process of thyroid. Based on the results of this study, despite all the limitations and controversies, the exciting and promising organoid technology offers researchers a wide range of potential applications for more accurate modeling of thyroid in health and diseases and provides an excellent preclinical in vitro platform. In future, organoid technology can provide a better understanding of the molecular mechanisms of pathogenesis and tumorigenesis of thyroid tissue and more effective treatment for related disorders due to more accurate simulation of the thyroid physiology.
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http://dx.doi.org/10.1152/ajpendo.00479.2020DOI Listing
March 2021

Association of Social Determinants of Health and Road Traffic Deaths: A Systematic Review.

Bull Emerg Trauma 2020 Oct;8(4):211-217

Sina Trauma and Surgery Research Center, Tehran University of Medical Sciences, Tehran, Iran.

Objective: This study aims to review systematically the association of social determinants of health (SDH) and road traffic deaths (RTD) within scientific literature.

Methods: A search strategy was designed and run in EMBASE, PubMed via MEDLINE, Scopus, Web of Science, and Cochrane library. Through title, abstract, and full-text screening, all English original papers (except ecological studies) which studied social determinants of health and fatal injuries were included. Papers which studied association between RTD and the education, income, rural settlement, and marital status were evaluated and the related data was extracted from the full-texts.

Results: Eleven articles out of 7,897 primary results were selected to be included in the study. Among eight papers studied education, seven confirmed a negative association between years of schooling and RTD. Two out of three articles reported no association between income leveland RTD. Among three papers studied rural settlement, two approved a positive relationship between this determinant and RTD. Both articles studied marital status, confirmed an association between this determinant and RTD.

Conclusion: A few papers studied association of social determinants of health (SDH) and RTD. There was an inverse relationship between education and RTD. The evidence for such an association between income, rural settlement, and marital state was scarce. Further investigations are recommended through original research.
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http://dx.doi.org/10.30476/beat.2020.86574DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7783304PMC
October 2020

The functional capacity and morphological characteristics of the intrinsic foot muscles in subjects with Hallux Valgus deformity: A systematic review.

Foot (Edinb) 2020 Dec 15;45:101706. Epub 2020 Jun 15.

Department of Rehabilitation Management, School of Rehabilitation Sciences, Iran University of Medical Sciences, Tehran, Iran. Electronic address:

Background: The intrinsic foot muscles are vital for maintaining normal foot function. This study was conducted to systematically review the literature on the functional capacity and morphological characteristics of the intrinsic foot muscles in subjects with Hallux Valgus (HV) deformity.

Methods: A search was carried out in all available electronic databases, including Pub Med, Scopus, Embase and Web of Science, for identifying any relevant studies published from 1990 to October 2018.

Results: Three studies had investigated intrinsic foot muscle size using ultrasound imaging; two had reported electromyography parameters and four had measured the muscle force capacity. The results of the present review suggested that the functional capacity and morphological characteristics of intrinsic foot muscles are different in subjects with HV compared to those without this deformity.

Conclusion: This review found scientific evidence on muscle performance impairment in the abductor hallucis and flexor hallucis brevis in subjects with HV deformity.
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http://dx.doi.org/10.1016/j.foot.2020.101706DOI Listing
December 2020

Molecular mechanisms of long non-coding RNAs in anaplastic thyroid cancer: a systematic review.

Cancer Cell Int 2020 29;20:352. Epub 2020 Jul 29.

Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.

Background: anaplastic thyroid cancer (ATC) is one of the most lethal and aggressive cancers. Evidence has shown that the tumorigenesis of ATC is a multistep process involving the accumulation of genetic and epigenetic changes. Several studies have suggested that long non-coding RNAs (lncRNAs) may play an important role in the development and progression of ATC. In this article, we have collected the published reports about the role of lncRNAs in ATC.

Methods: "Scopus", "Web of Science", "PubMed", "Embase", etc. were systematically searched for articles published since 1990 to 2020 in English language, using the predefined keywords.

Results: 961 papers were reviewed and finally 33 papers which fulfilled the inclusion and exclusion criteria were selected. Based on this systematic review, among a lot of evidences on examining the function of lncRNAs in thyroid cancer, there are only a small number of studies about the role of lncRNAs and their molecular mechanisms in the pathogenesis of ATC.

Conclusions: lncRNAs play a crucial role in regulation of different processes involved in the development and progression of ATC. Currently, just a few lncRNAs have been identified in ATC that may serve as prognosis markers such as GAS5, MIR22HG, and CASC2. Also, because of the dysregulation of Klhl14-AS, HOTAIRM1, and PCA3 during ATC development and progression, they may act as therapeutic targets. However, for most lncRNAs, only a single experiment has evaluated the expression profile in ATC tissues/cells. Therefore, further functional studies and expression profiling is needed to resolve this limitation and identify novel and valid biomarkers.
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http://dx.doi.org/10.1186/s12935-020-01439-wDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7392660PMC
July 2020

The effectiveness of negative pressure wound therapy as a novel management of diabetic foot ulcers: an overview of systematic reviews.

J Diabetes Metab Disord 2019 Dec 25;18(2):625-641. Epub 2019 Nov 25.

3Diabetes Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.

Background: Diabetic foot ulcer (DFU) is one the serious disabling conditions in patients with diabetes. Several approaches are available to manage DFU including Negative Pressure Wound Therapy (NPWT). The objective of this overview is systematically reviewing the related reviews about the effectiveness, safety, and cost benefits of NPWT interventions.

Methods: In October 2018, electronic databases including Medline, Embase, Scopous, Web of Science, the Cochrane Library and Google scholar were searched for systematic reviews about the NPWT's effectiveness and safety in DFUs. The Assessment of Multiple Systematic Reviews 2 (AMSTAR2) checklist was used for the appraisal of the systematic reviews. According to this checklist the studies were categorized as high, moderate, low and critically low quality.

Results: The electronic searches yielded 6889 studies. After excluding duplicates and those not fellfield the inclusion criteria, 23 systematic reviews were considered. The sample size of the reviews ranged between 20 and 2800 patients published since 2004 to 2018. Twenty systematic reviews (86.95%) included only randomized clinical trials (RCT). Regarding the AMSTAR-2 checklist, 7 studies were assigned to high quality, 8 were categorized as low quality and 8 studies belonged to the critically low quality groups. Accordingly, three, two and one out of seven high quality studies approved the effectiveness, safety and cost benefit of the NPWT therapy, respectively. However, some of them declared that there is some flaws in RCTs designing.

Conclusion: This overview illustrated that either systematic reviews or the included RCTs had wide variety of quality and heterogeneity in order to provide high level of evidence. Hence, well-designed RCTs as well as meta-analysis are required to shade the light on different aspects of NPWT.
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http://dx.doi.org/10.1007/s40200-019-00447-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6915190PMC
December 2019

MicroRNA-binding site polymorphisms and risk of colorectal cancer: A systematic review and meta-analysis.

Cancer Med 2019 12 21;8(17):7477-7499. Epub 2019 Oct 21.

Metabolic Disorders Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.

Genetic variations in miRNAs binding site might participate in cancer risk. This study aimed to systematically review the association between miRNA-binding site polymorphisms and colorectal cancer (CRC). Electronic literature search was carried out on PubMed, Web of Science (WOS), Scopus, and Embase. All types of observational studies till 30 November 2018 were included. Overall 85 studies (21 SNPs) from two systematic searches were included analysis. The results showed that in the Middle East population, the minor allele of rs731236 was associated with decreased risk of CRC (heterozygote model: 0.76 [0.61-0.95]). The minor allele of rs3025039 was related to increased risk of CRC in East Asian population (allelic model: 1.25 [1.01-1.54]). Results for rs3212986 were significant in overall and subgroup analysis (P < .05). For rs1801157 in subgroup analysis the association was significant in Asian populations (including allelic model: 2.28 [1.11-4.69]). For rs712, subgroup analysis revealed a significant (allelic model: 1.41 [1.23-1.61]) and borderline (allelic model: 0.92 [0.84-1.00]) association in Chinese and Czech populations, respectively. The minor allele of rs17281995 increased risk of CRC in different genetic models (P < .05). Finally, rs5275, rs4648298, and rs61764370 did not show significant associations. In conclusion, minor allele of rs3025039, rs3212986, and rs712 polymorphisms increases the risk of CRC in the East Asian population, and heterozygote model of rs731236 polymorphism shows protective effect in the Middle East population. In Europeans, the minor allele of rs17281995 may increase the risk of CRC, while rs712 may have a protective effect. Further analysis based on population stratifications should be considered in future studies.
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http://dx.doi.org/10.1002/cam4.2600DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6885874PMC
December 2019

Quality of reporting of randomized controlled trials of herbal medicines conducted in metabolic disorders in Middle East countries: A systematic review.

Complement Ther Med 2018 Jun 11;38:61-66. Epub 2018 Apr 11.

Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran. Electronic address:

Introduction: Based on WHO recommendation for considering herbal medicine as an inexpensive appropriate method to treat metabolic disorders, conducting randomized controlled trials (RCTs) is increasing worldwide. Since poor quality RCTs can lead to wrong conclusion, we assessed the quality of reporting of herbal medicines' RCTs conducted in Middle East in a systematic review study.

Materials & Methods: All herbal medicines' RCTs in metabolic disorders (diabetes mellitus, metabolic syndrome, hyperlipidemia, obesity and osteoporosis) conducted in Middle East countries and published before January 2017 were included. To obtain all related studies PubMed, Scopus, Web of Science, Cochran library, and Embase web databases were searched. Exclusion criteria were animal studies, non-herbal medicines' RCTs, RCTs conducted in Type 1 diabetes, in children or pregnant women. We used Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) checklist for reporting study selection processes as well as Consolidated Standards of Reporting Trials (CONSORT) statement for assessment of quality of reporting.

Results: Out of 5319 identified studies, 215 RCTs were included. The proportion of published RCTs in the topic increased significantly over the time (P < 0.001). The total mean ± SD score for 37 items of CONSORT checklist was 21.15 ± 4.27. Most of RCTs (60%) were not reported randomization in the title. Some important items were incompletely reported including trial registration (42.3%), sample size estimation (38.1%), randomization method (35.3%), generation of allocation (27.9%), and concealment of allocation (13.5%).

Conclusions: Our findings indicate that the quality of reporting of herbal medicines' RCTs in metabolic disorders has improved over time in Middle East, but remains suboptimal.
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http://dx.doi.org/10.1016/j.ctim.2018.04.004DOI Listing
June 2018

Efficacy, safety, and mechanisms of herbal medicines used in the treatment of obesity: A protocol for systematic review.

Medicine (Baltimore) 2018 Jan;97(1):e8825

Obesity and Eating Habits Research Center, Endocrinology and Metabolism Molecular -Cellular Sciences Institute Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran Department of Community Medicine, Alborz University of Medical Sciences, Karaj, Iran Chronic Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute Evidence Based Practice Research Center, Endocrinology and Metabolism Clinical Sciences Institute Department of Toxicology and Pharmacology, Faculty of Pharmacy, and Pharmaceutical Sciences Research Center, Tehran University of Medical Sciences, Tehran, Iran.

Introduction: This systematic review protocol aims to perform a protocol for assessing the effectiveness, safety, and mechanism of herbal medicines for the treatment of obesity and metabolic syndrome. Some systematic reviews conducted earlier have evaluated the efficacy of herbal medicine to treat obesity and metabolic syndrome. Owing to the huge burden imposed by obesity in the recent years, a need is felt for conducting new systematic reviews on the topic of obesity with a focus on randomized clinical trials, we felt the need.

Methods And Analysis: All relevant clinical trials that examine the effectiveness of herbal medicines for the treatment of obesity and metabolic syndrome without restrictions on publication status will be applied.Four electronic databases will be searched: PubMed, Scopus, Web of Science, and the Cochrane Central Register of Controlled Trials. The main outcome is expected to be an improvement in the body weight, body mass index, waist circumference, waist-to-hip ratio, body fat (weight or mass of visceral adipose tissue, fat mass or percent), and appetite.Selection studies, data extraction, and risk of bias will be assessed independently by 2 authors.

Ethics And Dissemination: In this study, ethical approval is not required because the data that will be used are not subjects and the results will be discussed through peer-reviewed publications.

Trial Registration Number: PROSPEROCRD42016049753.
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http://dx.doi.org/10.1097/MD.0000000000008825DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5943094PMC
January 2018

The Role of Mitochondrial DNA (mtDNA) in the Development of Diabetic Retinopathy (DR): A Systematic Review.

Med Hypothesis Discov Innov Ophthalmol 2017 ;6(2):30-38

Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.

Diabetic Retinopathy (DR) is the most prevalent health problem, which is influenced by environmental and genetic factors with an increasing prevalence. The current systematic review is focused on mtDNA modification, including polymorphism and mutation/deletion, with a direct effect on DR.This systematic search was initially done through PubMed, Cochrane, EMBASE, SCOPUS, and Web of Science without a restriction on the years of publication. The terms searched included ''mtDNA'', ''mitochondrial DNA'', ''diabetes'', ''diabetic'', ''retina'', and ''diabetic retinopathy''. Animal, cohort, cross-sectional, and in vitro studies, as well as case series, case reports, review articles, and Letters to Editor were excluded from this research.From 1528 resulting searched articles, only 12papers were finally chosen as the case-control studies considering mtDNA gene and DR. Actually, of these 12 articles, 8 studies were concerned with mtDNA polymorphisms (UCP1, UCP2, ROMO-1, and Mn-SOD) and 4 articles were related to mtDNA mutation (A3243G mutation in tRNA gene and mtDNA deletion (ΔmtDNA 4977)).Some conflicting results were found between the selected genetic modifications of mtDNA, such as Mn-SOD, UCP1, ΔmtDNA 4977, tRNALeu (UUR), and ROMO-1.Finally, A3243G mutation in the tRNA gene and rs660339 and V16A polymorphisms of UCP2 and Mn-SOD genes were respectively considered as the most important factors in the pathogenesis of DR.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5776499PMC
January 2017

A systematic review of preclinical studies on therapeutic potential of stem cells or stem cells products in peritoneal fibrosis.

Minerva Urol Nefrol 2018 Apr 31;70(2):162-178. Epub 2017 Mar 31.

Liver and Pancreatobiliary Diseases Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran.

Introduction: Peritoneal fibrosis remains a serious complication of long-term peritoneal dialysis. Stem cell therapy is an innovative field of scientific investigation with potential for clinical application. Here, we systematically reviewed the studies to determine whether stem cell based therapy could improve the peritoneal fibrosis in experimental models of peritoneal fibrosis.

Evidence Acquisition: Our systematic search of PubMed, Scopus, Web of Science, and Cochrane Library yield 5219 article. After screening for eligibility, in vivo, experimental, interventional studies using stem cells in animal models of peritoneal fibrosis; 11 articles were included. The studies underwent comprehensive review, quality assessment, and data extraction.

Evidence Synthesis: Mesenchymal stem cells were the most used type (90.9%) originated either from bone marrow (70%), adipose tissue (20%), or umbilical cord (10%). In 90.9% of studies, stem cells were injected after peritoneal insult and 63.6% of studies used the intraperitoneal injection route. Eight studies met the ≥50% of criteria indicated by ARRIVE recommendation. Information regarding the nature of ethical review permissions, species, strain and gender, dose, route and duration of treatment, was stated by all studies; 81.8% of the studies reported the number of animals in each group. Adverse events were reported in one study. Improvement in histological parameters including attenuation of submesothelial thickness (100%), inflammation (62.5%), angiogenesis (60%), and fibrosis (85.7%) was reported after stem cell therapy. Peritoneal permeability function by assessing the ultrafiltration, glucose transport and solute permeability was improved in all studies. Stem cell treatment resulted in mesothelial recovery in 100% of studies.

Conclusions: In preclinical studies, the use of stem cells is associated with improved peritoneal fibrosis. This may provide an important foundation to support future translational clinical research using stem cell therapy to repair the injured peritoneum and modulate immune responses in PD patients.
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http://dx.doi.org/10.23736/S0393-2249.17.02882-XDOI Listing
April 2018

Evaluating the effectiveness of peer-based intervention in managing type I diabetes mellitus among children and adolescents: A systematic review.

Med J Islam Repub Iran 2016;30:442. Epub 2016 Nov 19.

PhD, Professor of Clinical Epidemiology, Endocrine Research Center, Institute of Endocrinology & Metabolism, Iran University of Medical Sciences, Tehran, Iran.

Type 1 diabetes is one of the chronic metabolic disorders among children and adolescents. Peers are also important units in diabetes management through adolescence. This study aimed to evaluate the effectiveness of peer-based intervention in managing type 1 diabetes mellitus among children and adolescents. Searching articles published prior to December 2013 in PubMed, Web of Science, Cochrane library, Science Direct, Google scholar, CINAHL and Scopus, we found 8,548 publications. The first reviewer critically appraised the retrieved articles, using the CONSORT and the TREND checklists and then the second-assessor checked them. All abstracts were screened, and only eight full text articles remained for evaluation based on inclusion criteria Eight studies, including five randomized controlled trials, one controlled trial, and two pre-post trials were critically appraised based on CONSORT and the TREND checklists. The outcomes of these studies were as follows: knowledge (three studies), attitude (two studies), performance (one study), clinical parameters- exclusively HbA1c-(four studies), and psychosocial parameters-such as quality of life, coping, self-care, selfconfidence, satisfaction with the perceived social support, social skills, and diabetes-related conflicts The findings of this systematic review revealed that peer-based interventions could help to manage diabetes. While there is a lack of professional or family-based interventions and education, peers can be involved in the process of patient education. As there are few studies in the area of peer-based diabetes management, conducting further interventional studies with robust methodology is highly recommended.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5307630PMC
November 2016

Scientometric study of academic publications on antioxidative herbal medicines in type 2 diabetes mellitus.

J Diabetes Metab Disord 2016 21;15:48. Epub 2016 Oct 21.

Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.

Background: Scientometric analysis is increasingly used for research assessment. We aimed to perform a scientometric analysis of research productivity in field of antioxidative hypoglycemic herbal medicine and diabetes.

Methods: Some of search terms were "type 2 diabetes", "antioxidant", "herb", "phytotherapy", "ethnopharmacology", "Chinese medicine", "traditional medicine", in Scopus web databases until January 2015, and limited to human. The collected data were used to generate the specific features such as publication year, main journal in the field, citation, subject area, and co-authorship network of authors and institutes. Data was analyzed using analysis tools provided by Scopus database, SPSS version 11 and VOSviewer software.

Results: Overall, 468 studies were related to this topic in human. The number of publications in the field showed an increasing trend. Majority of the published papers were original articles (71 %) and the most productive year was 2013. Top subject areas were medicine followed by drug. The first productive country was the US. The documents were cited totally 10724 times with average citation/article 22.91, and h-index 55. The highest cited article was a systematic review study, and top source was "Journal of Ethnopharmacology". The highest international collaboration was with the US. Top authors and institutes in the co-authorship network assessment were from Iran.

Conclusions: A promising scientific productivity is shown in the studied field world wide. This study provided practical information to researchers who look for studies with potentially highly citation, and also would be helpful for researchers to conduct better researches that eventually could lead to more publications in this field.
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http://dx.doi.org/10.1186/s40200-016-0273-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5073927PMC
October 2016

Trends in publication on evidence-based antioxidative herbal medicines in management of diabetic nephropathy.

J Diabetes Metab Disord 2015 13;15. Epub 2016 Feb 13.

Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.

Background: Recently, popularity and use of herbal medicine in treatment of diabetes have been increased. Since, oxidative stress is known as the main underlying pathophysiology of diabetes and its complications, the purpose of this bibliometric study is to assess the global scientific production analysis and developing its trend in field of antioxidative hypoglycemic herbal medicines and diabetic nephropathy focusing on the scientific publication numbers, citations, geographical distribution in the world and determining the main journal (source) in the field.

Methods: Our search terms were "diabetes", "renal", "nephropathy", "herb", "Chinese medicine", "traditional medicine", and "antioxidant" from Scopus database until January 2015 and analysis of the distribution of words in the publication year, main journal (source) in the field, geographical distribution, documents' type and language, subject area, and h-index of citations were crried out. The Scopus analysis tools and VOSviewer software version 1.6.3 have been used for analysis.

Results: Within 1166 papers were published until year 2015, 78 studies were related to this topic in human. Increasing trend in number of related researches was shown. Fifty eight percent of the published papers were original articles, and the highest number was produced in 2013 with 21 documents. Top subject areas were medicine with global publication share of 71.8 %, and pharmacology was ranked the second (39.7 %). Iran was the first country with global publication. The total citation of the documents were 2518 times and h-index was 24. The highest cited paper was a review article with 336 citation number, and top source was "Journal of Medicinal Plants". Both of top authors and affiliation were from Iran; "Tehran University of Medical Sciences". Also, top author in the co-authorship mapping and clustering assessment was from Iran.

Conclusions: Although, we found an ascending trend of scientific publications in field of antioxidative herbal medicine and diabetic nephropathy with a good position for Iran, the number of publications is insufficient and more researches in this topic is necessary.
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http://dx.doi.org/10.1186/s40200-016-0221-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4752788PMC
February 2016

Vitamin B12 supplementation in end stage renal diseases: a systematic review.

Med J Islam Repub Iran 2015 27;29:167. Epub 2015 Jan 27.

MSc. in Medical Library & Information Science, Endocrinology and Metabolism Research Institute, Iran University of Medical Sciences, Tehran, Iran.

Background: Hyperhomocysteinemia is a risk factor for cardiovascular disease particularly in patients with end stage renal disease (ESRD). Vitamin B12 supplementation on its own still remains as a controversial issue for clinicians in decreasing the level of homcysteine in this group of patients.

Methods: Using all randomized controlled trials (RCTs), clinical trials and pre-post-trial studies found during January 1999 to March 2014, we conducted a systematic review which assessed the effects of vitamin B12 in decreasing homocysteine levels in patients with ESRD.

Results: The findings of this study revealed that, overall, the greatest effect of B12 supplementation on decreasing homocysteine levels in patients with ESRDs occurred when it was combined with folate supplementation. It was also demonstrated that injection treatments might be more beneficial than oral intake treatments.

Conclusion: More rigorous studies are needed to draw a firm conclusion about B12 therapy and the level of homocyteine in patients with ESRD.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4431359PMC
May 2015

Quality of reporting randomized controlled trials (RCTs) in diabetes in Iran; a systematic review.

J Diabetes Metab Disord 2015 7;15(1):36. Epub 2016 Sep 7.

Iran University of Medical Sciences, Tehran, Iran.

Objective: To determine the quality of randomized controlled clinical trial (RCT) reports in diabetes research in Iran.

Design: Systematized review.

Methods: We included RCTs conducted on diabetes mellitus in Iran. Animal studies, educational interventions, and non-randomized trials were excluded. We excluded duplicated publications reporting the same groups of participants and intervention. Two independent reviewers identify all eligible articles specifically designed data extraction form. We searched through international databases; Scopus, ProQuest, EBSCO, Science Direct, Web of Science, Cochrane Library, PubMed; and national databases (In Persian language) such as Magiran, Scientific Information Database (SID) and IranMedex from January 1995 to January of 2013 Two investigators assessed the quality of reporting by CONSORT 2010 (Consolidated Standards of Reporting Trials) checklist statemen.t,. Discrepancies were resolved by third reviewer consulting.

Results: One hundred and eight five (185) studies were included and appraised. Half of them (55.7 %) were published in Iranian journals. Most (89.7 %) were parallel RCTs, and being performed on type2 diabetic patients (77.8 %). Less than half of the CONSORT items (43.2 %) were reported in studies, totally. The reporting of randomization and blinding were poor. A few studies 15.1 % mentioned the method of random sequence generation and strategy of allocation concealment. And only 34.8 % of trials report how blinding was applied.

Conclusions: The findings of this study show that the quality of RCTs conducted in Iran in diabetes research seems suboptimal and the reporting is also incomplete however an increasing trend of improvement can be seen over time. Therefore, it is suggested Iranian researchers pay much more attention to design and methodological quality in conducting and reporting of diabetes RCTs.
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http://dx.doi.org/10.1186/s40200-016-0258-2DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5015251PMC
September 2016
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