Publications by authors named "Raphael Nemenoff"

100Publications

Eicosanoids in Cancer: New Roles in Immunoregulation.

Front Pharmacol 2020 18;11:595498. Epub 2020 Nov 18.

Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, United States.

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November 2020

Complement and Cancer-A Dysfunctional Relationship?

Antibodies (Basel) 2020 Nov 5;9(4). Epub 2020 Nov 5.

Division of Nephrology and Hypertension, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.

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November 2020

Complement factor H-deficient mice develop spontaneous hepatic tumors.

J Clin Invest 2020 Aug;130(8):4039-4054

Department of Medicine, Nephrology and Hypertension, University of Colorado School of Medicine, Aurora, Colorado, USA.

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August 2020

Renal double negative T cells: unconventional cells in search of a function.

Ann Transl Med 2019 Dec;7(Suppl 8):S342

Department of Medicine, Division of Renal Diseases and Hypertension, University of Colorado, Denver, Anschutz Medical Campus, Aurora, CO, USA.

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December 2019

PTEN (Phosphatase and Tensin Homolog) Protects Against Ang II (Angiotensin II)-Induced Pathological Vascular Fibrosis and Remodeling-Brief Report.

Arterioscler Thromb Vasc Biol 2020 02 19;40(2):394-403. Epub 2019 Dec 19.

From the Division of Renal Diseases and Hypertension, Department of Medicine (S.L., K.A.S., M.F.M., R.M.T., A.J.J., S.B.F., R.A.N., M.C.M.W.-E.), University of Colorado, Anschutz Medical Campus, Aurora.

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February 2020

Targeting the Complement Pathway as a Therapeutic Strategy in Lung Cancer.

Front Immunol 2019 10;10:954. Epub 2019 May 10.

Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, United States.

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June 2020

Inhibition of 5-lipoxygenase decreases renal fibrosis and progression of chronic kidney disease.

Am J Physiol Renal Physiol 2019 04 16;316(4):F732-F742. Epub 2019 Jan 16.

Division of Renal Diseases and Hypertension, University of Colorado-Anschutz Medical Campus , Denver, Colorado.

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April 2019

Subcellular Localization and Activity of the Mitogen-Activated Protein Kinase Kinase 7 (MKK7) Isoform are Regulated through Binding to the Phosphatase Calcineurin.

Mol Pharmacol 2019 01 7;95(1):20-32. Epub 2018 Nov 7.

Department of Pharmacology (E.S.G., K.M.W., M.L.D.) and Department of Medicine, Division of Renal Diseases and Hypertension (R.A.N.), University of Colorado School of Medicine, Aurora, Colorado; Department of Craniofacial Biology, University of Colorado School of Dental Medicine, Aurora, Colorado (L.E.H.); Immune Disease Institute, Harvard Medical School, Boston, Massachusetts (H.L.); and La Jolla Institute for Allergy and Immunology, La Jolla, California (P.G.H.)

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January 2019

CD8 T cells modulate autosomal dominant polycystic kidney disease progression.

Kidney Int 2018 12 21;94(6):1127-1140. Epub 2018 Sep 21.

Department of Medicine, Division of Renal Diseases and Hypertension, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA; Consortium for Fibrosis Research and Translation, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA. Electronic address:

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December 2018

Adenoviral vectors transduce alveolar macrophages in lung cancer models.

Oncoimmunology 2018;7(6):e1438105. Epub 2018 Mar 6.

Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Denver Anschutz Medical Campus, Aurora, CO.

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March 2018

A Beginner's Guide to Analyzing and Visualizing Mass Cytometry Data.

J Immunol 2018 01;200(1):3-22

Department of Anesthesiology, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO 80045;

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January 2018

Bone marrow-derived cPLA2α contributes to renal fibrosis progression.

J Lipid Res 2018 02 11;59(2):380-390. Epub 2017 Dec 11.

Department of Medicine, Renal Division, University of Colorado Anschutz Medical Campus, Aurora, CO.

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February 2018

Differentiated Smooth Muscle Cells Generate a Subpopulation of Resident Vascular Progenitor Cells in the Adventitia Regulated by Klf4.

Circ Res 2017 Jan 9;120(2):296-311. Epub 2016 Nov 9.

From the Division of Renal Diseases and Hypertension (H.H., A.O., S.L., A.B., J.P., R.A.N., M.C.M.W.-E.) and Cardiovascular Pulmonary Research Program, Division of Cardiology (R.A.N., M.C.M.W.-E.), School of Medicine, Consortium for Fibrosis Research and Translation, University of Colorado, Aurora (M.C.M.W.-E.); Division of Endocrinology, Department of Medicine, Indiana University, Indianapolis (J.N.R.); Center for Developmental Biology and Regenerative Medicine, Seattle Children's Research Institute, WA (M.W.M., X.R.D.); and Department of Pediatrics and Department of Pathology, University of Washington, Seattle (M.W.M.).

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January 2017

Cytosolic phospholipase Aα increases proliferation and de-differentiation of human renal tubular epithelial cells.

Prostaglandins Other Lipid Mediat 2016 11 21;126:1-8. Epub 2016 Aug 21.

Division of Renal Diseases and Hypertension, Department of Medicine, University of Colorado-Anschutz Medical Campus, Aurora, CO, United States; Denver Health and Hospitals, Denver, CO, United States.

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November 2016

Never make assumptions: the complicated role of complement in urinary tract infections.

Kidney Int 2016 09;90(3):469-71

Department of Medicine, University of Colorado School of Medicine, Anschutz Medical Campus, Aurora, Colorado, USA.

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September 2016

Nuclear PTEN functions as an essential regulator of SRF-dependent transcription to control smooth muscle differentiation.

Nat Commun 2016 Mar 4;7:10830. Epub 2016 Mar 4.

Department of Medicine, Division of Renal Diseases and Hypertension, University of Colorado, Anschutz Medical Campus, 12700 East 19th Avenue, C281, Research Complex 2, Room 7101, Aurora, Colorado 80045, USA.

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March 2016

Expression Profiling of Macrophages Reveals Multiple Populations with Distinct Biological Roles in an Immunocompetent Orthotopic Model of Lung Cancer.

J Immunol 2016 Mar 12;196(6):2847-59. Epub 2016 Feb 12.

Department of Medicine, University of Colorado Denver, Aurora, CO 80045; Department of Pharmacology, University of Colorado Denver, Aurora, CO 80045

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March 2016

Deletion of 5-Lipoxygenase in the Tumor Microenvironment Promotes Lung Cancer Progression and Metastasis through Regulating T Cell Recruitment.

J Immunol 2016 Jan 11;196(2):891-901. Epub 2015 Dec 11.

Department of Medicine, University of Colorado Denver, Aurora, CO 80045; Department of Pharmacology, University of Colorado Denver, Aurora, CO 80045

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January 2016

CD4 T cell knockout does not protect against kidney injury and worsens cancer.

J Mol Med (Berl) 2016 Apr 1;94(4):443-55. Epub 2015 Dec 1.

Division of Renal Diseases and Hypertension, Univ. of Colorado at Denver, Box C281, 12700 East, 19 th Ave, Aurora, CO, 80045, USA.

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April 2016

Homeoprotein Six2 promotes breast cancer metastasis via transcriptional and epigenetic control of E-cadherin expression.

Cancer Res 2014 Dec 27;74(24):7357-70. Epub 2014 Oct 27.

Department of Pharmacology, University of Colorado School of Medicine, Aurora, Colorado. Program in Molecular Biology, University of Colorado School of Medicine, Aurora, Colorado. Program in Cancer Biology, University of Colorado School of Medicine, Aurora, Colorado. Department of Biochemistry and Molecular Genetics, University of Colorado School of Medicine, Aurora, Colorado.

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December 2014

Activation of the retinoid X receptor modulates angiotensin II-induced smooth muscle gene expression and inflammation in vascular smooth muscle cells.

Mol Pharmacol 2014 Nov 28;86(5):570-9. Epub 2014 Aug 28.

Division of Renal Diseases and Hypertension (A.L., J.R.M., H.H., A.C.O., M.W.E., R.A.N., S.B.F.), Cardiovascular Pulmonary Research Laboratory, Department of Medicine (M.W.E., R.A.N.), University of Colorado Anschutz Medical Campus, Aurora, Colorado; and Department of Medicine, Denver Health Hospital, Denver, Colorado (S.B.F)

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November 2014

Vascular smooth muscle cell-derived transforming growth factor-β promotes maturation of activated, neointima lesion-like macrophages.

Arterioscler Thromb Vasc Biol 2014 Apr 13;34(4):877-86. Epub 2014 Feb 13.

From the Department of Medicine, Division of Renal Diseases and Hypertension (H.N.H., J.P., M.C.M.W.-E., R.A.N.), Department of Pharmacology (A.O., M.C.M.W.-E., R.A.N.), and Cardiovascular and Pulmonary Research Laboratory (M.C.M.W.-E., R.A.N.), University of Colorado Denver, Aurora.

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April 2014

Selective inactivation of PTEN in smooth muscle cells synergizes with hypoxia to induce severe pulmonary hypertension.

J Am Heart Assoc 2013 May 31;2(3):e000188. Epub 2013 May 31.

Division of Renal Diseases and Hypertension, Department of Medicine, University of Colorado, Anschutz Medical Campus, Aurora, CO 80045, USA.

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May 2013

Adipose lineage specification of bone marrow-derived myeloid cells.

Adipocyte 2012 Oct;1(4):215-229

Gates Center for Stem Cell Biology and Regenerative Medicine; University of Colorado Anschutz Medical Campus; Aurora, CO USA ; Department of Medicine; University of Colorado Anschutz Medical Campus; Aurora, CO USA.

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October 2012

Knockdown of secretory phospholipase A2 IIa reduces lung cancer growth in vitro and in vivo.

J Thorac Cardiovasc Surg 2012 Nov;144(5):1185-91

Section of General Thoracic Surgery, Division of Cardiothoracic Surgery, Department of Surgery, University of Colorado School of Medicine, Aurora, CO, USA.

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November 2012

Group IIa secretory phospholipase expression correlates with group IIa secretory phospholipase inhibition-mediated cell death in K-ras mutant lung cancer cells.

J Thorac Cardiovasc Surg 2012 Dec 29;144(6):1479-85. Epub 2012 Sep 29.

Division of Cardiothoracic Surgery, Department of Surgery, University of Colorado School of Medicine, Aurora, Colo 80045, USA.

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December 2012

Anti- and Protumorigenic Effects of PPARγ in Lung Cancer Progression: A Double-Edged Sword.

PPAR Res 2012 12;2012:362085. Epub 2012 Aug 12.

Division of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, University of Colorado Denver, Aurora, CO 80045, USA.

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August 2012

Activation of PPARγ in myeloid cells promotes lung cancer progression and metastasis.

Authors:
Raphael Nemenoff

Oncoimmunology 2012 May;1(3):403-404

Department of Medicine; University of Colorado Denver; Aurora, CO USA.

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May 2012

Activation of PPARγ in myeloid cells promotes lung cancer progression and metastasis.

PLoS One 2011 1;6(12):e28133. Epub 2011 Dec 1.

Division of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, United States of America.

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May 2012

Serum response factor regulates expression of phosphatase and tensin homolog through a microRNA network in vascular smooth muscle cells.

Arterioscler Thromb Vasc Biol 2011 Dec 22;31(12):2909-19. Epub 2011 Sep 22.

Department of Medicine, Division of Renal Diseases and Hypertension, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.

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December 2011

Splenectomy exacerbates lung injury after ischemic acute kidney injury in mice.

Am J Physiol Renal Physiol 2011 Oct 15;301(4):F907-16. Epub 2011 Jun 15.

Department of Medicine, Division of Renal Diseases and Hypertension, University of Colorado Denver, Aurora, Colorado, USA.

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October 2011

SDF-1α induction in mature smooth muscle cells by inactivation of PTEN is a critical mediator of exacerbated injury-induced neointima formation.

Arterioscler Thromb Vasc Biol 2011 Jun 17;31(6):1300-8. Epub 2011 Mar 17.

Division of Renal Diseases and Hypertension, Department of Medicine, University of Colorado Denver, Aurora, CO 80045, USA.

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June 2011

Sprouty-4 inhibits transformed cell growth, migration and invasion, and epithelial-mesenchymal transition, and is regulated by Wnt7A through PPARgamma in non-small cell lung cancer.

Mol Cancer Res 2010 Jun 25;8(6):833-43. Epub 2010 May 25.

University of Colorado at Denver and Health Sciences Center, 12700 East 19th Avenue, Box C272, RC2 9th Floor, Aurora, CO 80045, USA.

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June 2010

Peroxisome proliferator-activated receptor-gamma inhibits transformed growth of non-small cell lung cancer cells through selective suppression of Snail.

Neoplasia 2010 Mar;12(3):224-34

Division of Renal Diseases and Hypertension, Department of Medicine, University of Colorado-Denver, 12700 E 19th Ave., Aurora, CO 80045, USA.

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March 2010

Altered expression of genes profiles modulated by a combination of Astragali Radix and Angelicae Sinensis Radix in obstructed rat kidney.

Planta Med 2010 Sep 1;76(13):1431-8. Epub 2010 Mar 1.

Renal Division, Department of Medicine, Peking University First Hospital, Beijing, China.

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September 2010

Inactivation of the tumour suppressor, PTEN, in smooth muscle promotes a pro-inflammatory phenotype and enhances neointima formation.

Cardiovasc Res 2010 May 5;86(2):274-82. Epub 2010 Jan 5.

Division of Renal Diseases and Hypertension, Department of Medicine, University of Colorado Denver, Aurora, CO 80045, USA.

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May 2010

Participation of ATP7A in macrophage mediated oxidation of LDL.

J Lipid Res 2010 Jun 23;51(6):1471-7. Epub 2009 Nov 23.

Division of Cardiovascular Diseases, Genome Research Institute, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA.

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June 2010

Depletion of cytosolic phospholipase A2 in bone marrow-derived macrophages protects against lung cancer progression and metastasis.

Cancer Res 2009 Mar 10;69(5):1733-8. Epub 2009 Feb 10.

Division of Renal Diseases and Hypertension and Pulmonary Sciences, University of Colorado Denver, Denver, Colorado 80262, USA.

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March 2009

Cox-2 inactivates Smad signaling and enhances EMT stimulated by TGF-beta through a PGE2-dependent mechanisms.

Carcinogenesis 2008 Nov 25;29(11):2227-35. Epub 2008 Aug 25.

Department of Pharmacology, University of Colorado Health Sciences Center, Aurora, CO 80045, USA.

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November 2008

Activation and Molecular Targets of Peroxisome Proliferator-Activated Receptor-gamma Ligands in Lung Cancer.

PPAR Res 2008 ;2008:156875

Division of Renal Diseases, Department of Medicine, School of Medicine, University of Colorado Denver, Denver, CO 80262, USA.

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July 2011

Antitumorigenic effects of peroxisome proliferator-activated receptor-gamma in non-small-cell lung cancer cells are mediated by suppression of cyclooxygenase-2 via inhibition of nuclear factor-kappaB.

Mol Pharmacol 2008 Mar 30;73(3):709-17. Epub 2007 Nov 30.

Division of Renal Diseases and Hypertension, Department of Medicine, University of Colorado Health Sciences Center, Box C-281, 4200 East 9th Avenue, Denver, CO 80262, USA.

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March 2008

Peroxisome proliferator-activated receptor-gamma in lung cancer: defining specific versus "off-target" effectors.

J Thorac Oncol 2007 Nov;2(11):989-92

Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA.

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November 2007

Antitumorigenic effect of Wnt 7a and Fzd 9 in non-small cell lung cancer cells is mediated through ERK-5-dependent activation of peroxisome proliferator-activated receptor gamma.

J Biol Chem 2006 Sep 11;281(37):26943-50. Epub 2006 Jul 11.

Veterans Administration Medical Center, Denver, and Department of Medicine, University of Colorado Health Sciences Center, 80220, USA.

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September 2006

Attenuation of the pulmonary inflammatory response following butylated hydroxytoluene treatment of cytosolic phospholipase A2 null mice.

Am J Physiol Lung Cell Mol Physiol 2006 Jun 27;290(6):L1260-6. Epub 2006 Jan 27.

University of Colorado Health Sciences Center, School of Pharmacy, Box C238, 4200 E. 9th Avenue, Denver, CO 80262, USA.

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June 2006

Prostacyclin synthase promoter regulation and familial pulmonary arterial hypertension.

Chest 2005 Dec;128(6 Suppl):612S

Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA.

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December 2005

Role of nuclear receptors in lung tumourigenesis.

Eur J Cancer 2005 Nov 30;41(16):2561-8. Epub 2005 Sep 30.

Division of Renal Diseases and Hypertension, Department of Medicine, University of Colorado Health Sciences Center, Campus Box C-281, 4200 East 9th Avenue, Denver, CO 80262, USA.

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November 2005

Lung Krüppel-like factor (LKLF) is a transcriptional activator of the cytosolic phospholipase A2 alpha promoter.

Biochem J 2005 Apr;387(Pt 1):239-46

Department of Medicine, University of Colorado Health Sciences Center, 4200 E. 9th Ave., Denver, CO 80262, USA.

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April 2005

Multiple signaling conduits regulate global differentiation-specific gene expression in PC12 cells.

J Cell Physiol 2004 Dec;201(3):459-69

Department of Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA.

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December 2004

Pulmonary prostacyclin synthase overexpression chemoprevents tobacco smoke lung carcinogenesis in mice.

Cancer Res 2004 Aug;64(16):5897-904

Division of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, Denver VA Medical Center, Denver, Colorado, USA.

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August 2004

Prostacyclin in human non-small cell lung cancers.

Chest 2004 May;125(5 Suppl):141S

Division of Pulmonary Sciences and Critical Care Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA.

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May 2004

Paired-related homeobox gene Prx1 is required for pulmonary vascular development.

Circ Res 2004 Jun 29;94(11):1507-14. Epub 2004 Apr 29.

Department of Pediatrics, University of Colorado Health Sciences Center, Denver, CO 80262, USA.

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June 2004

Decreased lung tumorigenesis in mice genetically deficient in cytosolic phospholipase A2.

Carcinogenesis 2004 Aug 19;25(8):1517-24. Epub 2004 Mar 19.

Department of Pharmacology, University of Colorado Health Sciences Center, 4200 E. 9th Avenue, Denver, CO 80262, USA.

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August 2004

Regulation of SM22 alpha expression by arginine vasopressin and PDGF-BB in vascular smooth muscle cells.

Am J Physiol Heart Circ Physiol 2003 Oct 26;285(4):H1444-52. Epub 2003 Jun 26.

Department of Medicine, University of Colorado Health Sciences Center, 4200 E. Ninth Ave., Denver, CO 80262, USA.

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October 2003

Increased epoxyeicosatrienoic acid formation in the rat kidney during liver cirrhosis.

J Am Soc Nephrol 2003 Jul;14(7):1766-75

Cardiovascular-Pulmonary Research Laboratory, Department of Medicine, University of Colorado Health Sciences Center, 4200 East 9th Avenue, Denver, CO 80262, USA.

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July 2003

Perlecan up-regulation of FRNK suppresses smooth muscle cell proliferation via inhibition of FAK signaling.

Mol Biol Cell 2003 May 26;14(5):1941-52. Epub 2003 Jan 26.

Department of Pediatrics, Renal Division, University of Colorado Health Sciences Center, Denver 80262, USA.

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May 2003

Induction of SM-alpha-actin expression by mechanical strain in adult vascular smooth muscle cells is mediated through activation of JNK and p38 MAP kinase.

Biochem Biophys Res Commun 2003 Feb;301(4):1116-21

Department of Pediatrics, Division of Renal Diseases and Hypertension, University of Colorado Health Sciences Center, Box C-281, 4200 E. Ninth Ave., Denver, CO 80262, USA.

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February 2003

Hypoxic activation of adventitial fibroblasts: role in vascular remodeling.

Chest 2002 Dec;122(6 Suppl):326S-334S

Developmental Lung Biology Research Laboratory, University of Colorado Health Sciences Center, Denver, CO 80262, USA.

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December 2002

Effects of angiotensin receptor blockade on haemodynamics and gene expression after myocardial infarction.

Drugs R D 2002 ;3(4):239-49

Department of Medicine, Division of Renal Diseases and Hypertension, University of Colorado Health Sciences Center, Denver, Colorado, USA.

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May 2003

Manipulation of pulmonary prostacyclin synthase expression prevents murine lung cancer.

Cancer Res 2002 Feb;62(3):734-40

Division of Pulmonary Sciences and Critical Care Medicine, Department of Medicine, Denver VA Medical Center, Denver, CO 80220, USA.

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February 2002