Publications by authors named "Ranjeet A Bapat"

9 Publications

  • Page 1 of 1

Recent advances and prospects in gemcitabine drug delivery systems.

Int J Pharm 2021 Jan 3;592:120043. Epub 2020 Nov 3.

Department of Pharmaceutics, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi 110062, India. Electronic address:

Cancer is a community health hazard which progress at a fatal rate in various countries across the globe. An agent used for chemotherapy should exhibit ideal properties to be an effective anticancer medicine. The chemotherapeutic medicines used for treatment of various cancers are, gemcitabine, paclitaxel, etoposide, methotrexate, cisplatin, doxorubicin and 5-fluorouracil. However, many of these agents present nonspecific systemic toxicity that prevents their treatment efficiency. Of all, gemcitabine has shown to be an active agent against colon, pancreatic, colon, ovarian, breast, head and neck and lung cancers in amalgamation with various anticancer agents. Gemcitabine is considered a gold-standard and the first FDA approved agent used as a monotherapy in management of advanced pancreatic cancers. However due to its poor pharmacokinetics, there is need of newer drug delivery system for efficient action. Nanotechnology has shown to be an emerging trend in field of medicine in providing novel modalities for cancer treatment. Various nanocarriers have the potential to deliver the drug at the desired site to obtain information about diagnosis and treatment of cancer. This review highlights on various nanocarriers like polymeric nanoparticles, solid lipid nanoparticles, mesoporous silica nanoparticles, magnetic nanoparticles, micelles, liposomes, dendrimers, gold nanoparticles and combination approaches for delivery of gemcitabine for cancer therapy. The co-encapsulation and concurrent delivery of Gem with other anticancer agents can enhance drug action at the cancer site with reduced side effects.
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http://dx.doi.org/10.1016/j.ijpharm.2020.120043DOI Listing
January 2021

Recent advances of gold nanoparticles as biomaterial in dentistry.

Int J Pharm 2020 Aug 2;586:119596. Epub 2020 Jul 2.

Department of Pharmaceutics, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi 110062, India. Electronic address:

Major goal of dental treatment is to eradicate the existing diseases of the oral cavity and implement preventive measures to control the spread of the diseases. Various interventions are being used to cure the dental diseases. Due to the nanostructures, high surface volume and biocompatibility, Gold nanoparticles (GNPs) have been experimented in the treatment of gum diseases, dental caries, tissue engineering, dental implantology and diagnosis of cancers. GNPs possess antifungal and antibacterial activity, hence are incorporated in various biomaterials to potentiate the effect. They also enhance the mechanical properties of materials leading to improved outcomes. They are available in different sizes and concentrations to exhibits its beneficial outcomes. These properties of GNPs make these materials as choice of fillers in biomaterials. This review aims to discuss the effect of incorporation of GNPs in several biomaterials used for dental and medical applications.
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http://dx.doi.org/10.1016/j.ijpharm.2020.119596DOI Listing
August 2020

The potential of dendrimer in delivery of therapeutics for dentistry.

Heliyon 2019 Oct 23;5(10):e02544. Epub 2019 Oct 23.

Department of Pharmaceutics, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi, 110062, India.

Dendrimers are hyperbranched nanoparticle structures along with its surface modifications can to be used in dental biomaterials for biomimetic remineralisation of enamel and dentin. The review highlights the therapeutic applications of dendrimers in the field of dentistry. It addresses the possible mechanisms of enhancement of mechanical properties of adhesives and resins structure. Dendrimers due to its unique construction of possessing inner hydrophobic and outer hydrophilic structure can act as drug carrier for delivery of antimicrobial drugs for treatment of periodontal diseases and at peripheral dental implant areas. Dendrimers due to its hyperbranched structures can provides a unique drug delivery vehicle for delivery of a drug at specific site for sustained release for therapeutic effects. Thus, dendrimers can be one of the most important constituents which can be incorporated in dental biomaterials for better outcomes in dentistry.
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http://dx.doi.org/10.1016/j.heliyon.2019.e02544DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6820096PMC
October 2019

The use of nanoparticles as biomaterials in dentistry.

Drug Discov Today 2019 01 31;24(1):85-98. Epub 2018 Aug 31.

Department of Pharmaceutical Technology, The International Medical University, Jalan Jalil Perkasa 19, Kuala Lumpur 57000, Malaysia. Electronic address:

Maintenance of oral health is a major challenge in dentistry. Different materials have been used to treat various dental diseases, although treatment success is limited by features of the biomaterials used. To overcome these limitations, materials incorporated with nanoparticles (NPs) can be used in dental applications including endodontics, periodontics, tissue engineering, oral surgery, and imaging. The unique properties of NPs, including their surface:volume ratio, antibacterial action, physical, mechanical, and biological characteristics, and unique particle size have rendered them effective vehicles for dental applications. In this review, we provide insights into the various applications of NPs in dentistry, including their benefits, limitations, properties, actions and future potential.
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http://dx.doi.org/10.1016/j.drudis.2018.08.012DOI Listing
January 2019

An overview of application of silver nanoparticles for biomaterials in dentistry.

Mater Sci Eng C Mater Biol Appl 2018 Oct 25;91:881-898. Epub 2018 May 25.

International Medical University, School of Pharmacy, Department of Pharmaceutical Technology, 57000 Kuala Lumpur, Malaysia. Electronic address:

Oral cavity is a gateway to the entire body and protection of this gateway is a major goal in dentistry. Plaque biofilm is a major cause of majority of dental diseases and although various biomaterials have been applied for their cure, limitations pertaining to the material properties prevent achievement of desired outcomes. Nanoparticle applications have become useful tools for various dental applications in endodontics, periodontics, restorative dentistry, orthodontics and oral cancers. Off these, silver nanoparticles (AgNPs) have been used in medicine and dentistry due to its antimicrobial properties. AgNPs have been incorporated into biomaterials in order to prevent or reduce biofilm formation. Due to greater surface to volume ratio and small particle size, they possess excellent antimicrobial action without affecting the mechanical properties of the material. This unique property of AgNPs makes these materials as fillers of choice in different biomaterials whereby they play a vital role in improving the properties. This review aims to discuss the influence of addition of AgNPs to various biomaterials used in different dental applications.
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http://dx.doi.org/10.1016/j.msec.2018.05.069DOI Listing
October 2018

Allergic contact dermatitis caused by polymethylmethacrylate following intradermal filler injection.

Contact Dermatitis 2017 Dec;77(6):407-408

Department of Periodontology and Oral Implantology, D. Y. Patil School of Dentistry, 400706, Navi Mumbai, Maharashtra, India.

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http://dx.doi.org/10.1111/cod.12779DOI Listing
December 2017

Allergic contact stomatitis caused Salvadora persica in toothpaste.

Contact Dermatitis 2017 Nov;77(5):325-326

Cosmetic Dentist, Mumbai 400091, India.

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http://dx.doi.org/10.1111/cod.12819DOI Listing
November 2017

Allergic contact stomatitis caused by camphorquinone in a light cure periodontal dressing.

Contact Dermatitis 2017 Oct;77(4):251-252

Department of Periodontics, D. Y. Patil School of Dentistry, Nerul, Navi Mumbai, 400706, India.

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http://dx.doi.org/10.1111/cod.12794DOI Listing
October 2017

Allergic contact dermatitis caused by latex gloves in a dental undergraduate student.

Contact Dermatitis 2016 Oct;75(4):256-7

Department of Periodontology and Oral Implantology, DY Patil University School of Dentistry, 400706, Navi Mumbai, India.

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http://dx.doi.org/10.1111/cod.12625DOI Listing
October 2016
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