Publications by authors named "Rani E George"

43Publications

Formation of Human Neuroblastoma in Mouse-Human Neural Crest Chimeras.

Cell Stem Cell 2020 04 5;26(4):579-592.e6. Epub 2020 Mar 5.

Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA; Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02142, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2020.02.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7663823PMC
April 2020

Ex vivo screen identifies CDK12 as a metastatic vulnerability in osteosarcoma.

J Clin Invest 2019 10;129(10):4377-4392

Department of Genetics and Genome Sciences, Case Western Reserve University School of Medicine, Case Comprehensive Cancer Center, Cleveland, Ohio, USA.

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https://www.jci.org/articles/view/127718
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http://dx.doi.org/10.1172/JCI127718DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6763270PMC
October 2019

Chemically Induced Degradation of Anaplastic Lymphoma Kinase (ALK).

J Med Chem 2018 05 24;61(9):4249-4255. Epub 2018 Apr 24.

Department of Biological Chemistry & Molecular Pharmacology , Harvard Medical School , Boston , Massachusetts 02115 , United States.

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http://pubs.acs.org/doi/10.1021/acs.jmedchem.7b01655
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http://dx.doi.org/10.1021/acs.jmedchem.7b01655DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6294449PMC
May 2018

Overcoming Resistance to the THZ Series of Covalent Transcriptional CDK Inhibitors.

Cell Chem Biol 2018 02 21;25(2):135-142.e5. Epub 2017 Dec 21.

Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA; Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.chembiol.2017.11.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6389506PMC
February 2018

Super-Enhancer-Driven Transcriptional Dependencies in Cancer.

Trends Cancer 2017 04 12;3(4):269-281. Epub 2017 Apr 12.

Department of Pediatric Hematology and Oncology, Dana-Farber Cancer Institute and Boston Children's Hospital, Boston, MA 02215, USA; Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S24058033173006
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http://dx.doi.org/10.1016/j.trecan.2017.03.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5546010PMC
April 2017

Cbx3/HP1γ deficiency confers enhanced tumor-killing capacity on CD8 T cells.

Sci Rep 2017 02 21;7:42888. Epub 2017 Feb 21.

Beth Israel Deaconess Medical Center, Harvard Medical School, Department of Pathology, Boston, MA 02215, USA.

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http://www.nature.com/articles/srep42888
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http://dx.doi.org/10.1038/srep42888DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5318867PMC
February 2017

Glutathione biosynthesis is upregulated at the initiation of MYCN-driven neuroblastoma tumorigenesis.

Mol Oncol 2016 06 2;10(6):866-78. Epub 2016 Mar 2.

Children's Cancer Institute, Lowy Cancer Research Centre, University of New South Wales, Randwick 2031, Australia; Kids Cancer Centre, Sydney Children's Hospital, Randwick 2031, Australia. Electronic address:

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http://dx.doi.org/10.1016/j.molonc.2016.02.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5423163PMC
June 2016

Targeting ALK: The Ten Lives of a Tumor.

Cancer Discov 2016 Jan;6(1):20-1

Department of Pediatric Hematology and Oncology, Dana-Farber Cancer Institute and Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1158/2159-8290.CD-15-1411DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4709027PMC
January 2016

TERT rearrangements are frequent in neuroblastoma and identify aggressive tumors.

Nat Genet 2015 Dec 2;47(12):1411-4. Epub 2015 Nov 2.

Department of Oncogenomics, Academic Medical Center, Amsterdam, the Netherlands.

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http://dx.doi.org/10.1038/ng.3438DOI Listing
December 2015

Seek and Ye Shall Find: Subclonal Anaplastic Lymphoma Kinase Mutations.

Authors:
Rani E George

Clin Cancer Res 2015 Nov 11;21(21):4747-9. Epub 2015 Sep 11.

Department of Pediatric Hematology and Oncology, Dana-Farber Cancer Institute and Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1158/1078-0432.CCR-15-1397DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4631645PMC
November 2015

A phase I trial combining decitabine/dendritic cell vaccine targeting MAGE-A1, MAGE-A3 and NY-ESO-1 for children with relapsed or therapy-refractory neuroblastoma and sarcoma.

Cancer Immunol Immunother 2015 Oct 24;64(10):1251-60. Epub 2015 Jun 24.

Department of Pediatrics, Hematology/Oncology, University of Louisville, 571 South Floyd Street, Suite 445, Louisville, KY, 40202, USA.

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http://dx.doi.org/10.1007/s00262-015-1731-3DOI Listing
October 2015

CDK7 inhibition suppresses super-enhancer-linked oncogenic transcription in MYCN-driven cancer.

Cell 2014 Nov 6;159(5):1126-1139. Epub 2014 Nov 6.

Department of Pediatric Hematology/Oncology, Dana-Farber Cancer Institute and Boston Children's Hospital, Boston, MA 02215, USA; Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2014.10.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4243043PMC
November 2014

Distinct neuroblastoma-associated alterations of PHOX2B impair sympathetic neuronal differentiation in zebrafish models.

PLoS Genet 2013 Jun 6;9(6):e1003533. Epub 2013 Jun 6.

Department of Pediatric Oncology, Dana-Farber Cancer Institute, Division of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1371/journal.pgen.1003533DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3675015PMC
June 2013

Promising therapeutic targets in neuroblastoma.

Clin Cancer Res 2012 May;18(10):2740-53

Department of Pediatrics, UCSF Helen Diller Family Comprehensive Cancer Center, and UCSF Benioff Children's Hospital, UCSF Medical Center, University of California, San Francisco, CA 94143-0106, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-11-1939DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3382042PMC
May 2012

Tumor histology during induction therapy in patients with high-risk neuroblastoma.

Pediatr Blood Cancer 2012 Sep 11;59(3):506-10. Epub 2011 Dec 11.

Department of Pediatric Hematology and Oncology, Dana-Farber Cancer Institute and Children's Hospital, Boston, MA 02115, USA.

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http://dx.doi.org/10.1002/pbc.24013DOI Listing
September 2012

Emerging importance of ALK in neuroblastoma.

Semin Cancer Biol 2011 Oct 16;21(4):267-75. Epub 2011 Sep 16.

Department of Pediatric Hematology and Oncology, Dana Farber Cancer Institute and Children's Hospital Boston, Harvard Medical School, 450 Brookline Ave, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.semcancer.2011.09.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3242371PMC
October 2011

Pharmacotherapy of neuroblastoma.

Expert Opin Pharmacother 2010 Jun;11(9):1467-78

Dana-Faber Cancer Institute, Department of Pediatric Oncology, Boston, MA, USA.

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http://www.tandfonline.com/doi/full/10.1517/14656566.2010.48
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http://dx.doi.org/10.1517/14656566.2010.482100DOI Listing
June 2010

Anaplastic lymphoma kinase: role in cancer pathogenesis and small-molecule inhibitor development for therapy.

Expert Rev Anticancer Ther 2009 Mar;9(3):331-56

Department of Chemical Biology and Therapeutics, St Jude Children's Research Hospital, 332 North Lauderdale Street, Mail Stop 1000, Memphis, TN 38105, USA.

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http://www.tandfonline.com/doi/full/10.1586/14737140.9.3.331
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http://dx.doi.org/10.1586/14737140.9.3.331DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2780428PMC
March 2009

Does MYCN amplification manifested as homogeneously staining regions at diagnosis predict a worse outcome in children with neuroblastoma? A Children's Oncology Group study.

Clin Cancer Res 2006 Oct;12(19):5693-7

The National Center for Pediatric Cancer Genetics, Children's Oncology Group, University of Florida, Gainesville, FL, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-06-1500DOI Listing
October 2006

Zebrafish foxd3 is selectively required for neural crest specification, migration and survival.

Dev Biol 2006 Apr 23;292(1):174-88. Epub 2006 Feb 23.

Department of Pediatric Oncology, Dana-Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA.

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http://dx.doi.org/10.1016/j.ydbio.2005.12.035DOI Listing
April 2006

Hyperdiploidy plus nonamplified MYCN confers a favorable prognosis in children 12 to 18 months old with disseminated neuroblastoma: a Pediatric Oncology Group study.

J Clin Oncol 2005 Sep 22;23(27):6466-73. Epub 2005 Aug 22.

Department of Pediatric Hematology and Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1200/JCO.2005.05.582DOI Listing
September 2005

Association between congenital cardiovascular malformations and neuroblastoma.

J Pediatr 2004 Apr;144(4):444-8

Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1016/j.jpeds.2003.12.032DOI Listing
April 2004