Randy L Johnson

Randy L Johnson

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Randy L Johnson

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Activation of the intrinsic fibroinflammatory program in adult pancreatic acinar cells triggered by Hippo signaling disruption.

PLoS Biol 2019 Sep 12;17(9):e3000418. Epub 2019 Sep 12.

Department of Cell Systems & Anatomy, UT Health San Antonio, San Antonio, Texas, United States of America.

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http://dx.doi.org/10.1371/journal.pbio.3000418DOI Listing
September 2019

Hippo signaling and epithelial cell plasticity in mammalian liver development, homeostasis, injury and disease.

Authors:
Randy L Johnson

Sci China Life Sci 2019 Aug 26. Epub 2019 Aug 26.

Department of Cancer Biology, University of Texas, MD Anderson Cancer Center, 6767 Bertner Ave, Houston, TX, 77030, USA.

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http://dx.doi.org/10.1007/s11427-018-9510-3DOI Listing
August 2019

and are required for ovarian granulosa cell fate maintenance.

FASEB J 2019 Jul 3:fj201900609R. Epub 2019 Jul 3.

Département de Biomédecine Vétérinaire, Centre de Recherche en Reproduction et Fertilité, Faculté de Médecine Vétérinaire, Université de Montréal, Saint-Hyacinthe, Québec, Canada.

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http://dx.doi.org/10.1096/fj.201900609RDOI Listing
July 2019

Homeostatic and tumourigenic activity of SOX2+ pituitary stem cells is controlled by the LATS/YAP/TAZ cascade.

Elife 2019 Mar 26;8. Epub 2019 Mar 26.

Centre for Craniofacial and Regenerative Biology, Faculty of Dentistry, Oral & Craniofacial Sciences, King's College London, London, United Kingdom.

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http://dx.doi.org/10.7554/eLife.43996DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6461440PMC
March 2019

FGF15 Activates Hippo Signaling to Suppress Bile Acid Metabolism and Liver Tumorigenesis.

Dev Cell 2019 02 7;48(4):460-474.e9. Epub 2019 Feb 7.

State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Xiamen, Fujian 361102, China; Cancer Research Center of Xiamen University, Xiamen, Fujian 361102, China. Electronic address:

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http://dx.doi.org/10.1016/j.devcel.2018.12.021DOI Listing
February 2019

Macrophage achieves self-protection against oxidative stress-induced ageing through the Mst-Nrf2 axis.

Nat Commun 2019 02 14;10(1):755. Epub 2019 Feb 14.

State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Xiamen, Fujian, 361102, China.

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http://dx.doi.org/10.1038/s41467-019-08680-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6376064PMC
February 2019

The signaling protein Wnt5a promotes TGFβ1-mediated macrophage polarization and kidney fibrosis by inducing the transcriptional regulators Yap/Taz.

J Biol Chem 2018 12 17;293(50):19290-19302. Epub 2018 Oct 17.

From the Center for Kidney Disease, 2nd Affiliated Hospital, Nanjing Medical University, 262 North Zhongshan Road, Nanjing, 210003 Jiangsu, China and

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http://dx.doi.org/10.1074/jbc.RA118.005457DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6302175PMC
December 2018

The Hippo Pathway Prevents YAP/TAZ-Driven Hypertranscription and Controls Neural Progenitor Number.

Dev Cell 2018 12 25;47(5):576-591.e8. Epub 2018 Oct 25.

Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA. Electronic address:

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http://dx.doi.org/10.1016/j.devcel.2018.09.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6296252PMC
December 2018

inactivation reveals Hippo function in alveolar type I cell differentiation during lung transition to air breathing.

Development 2018 11 9;145(21). Epub 2018 Nov 9.

Laboratory of Genetics, Department of Medical Genetics, University of Wisconsin-Madison, Madison, WI 53706, USA

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http://dev.biologists.org/lookup/doi/10.1242/dev.163105
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http://dx.doi.org/10.1242/dev.163105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6240317PMC
November 2018

Publisher Correction: The transcriptional coactivator TAZ regulates reciprocal differentiation of T17 cells and T cells.

Nat Immunol 2018 Sep;19(9):1036

State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Xiamen, Fujian, China.

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http://dx.doi.org/10.1038/s41590-018-0055-9DOI Listing
September 2018

Galectin-3 Mediates Tumor Cell-Stroma Interactions by Activating Pancreatic Stellate Cells to Produce Cytokines via Integrin Signaling.

Gastroenterology 2018 04 21;154(5):1524-1537.e6. Epub 2017 Dec 21.

Department of Gastrointestinal Medical Oncology, University of Texas M.D. Anderson Cancer Center, Houston, Texas. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2017.12.014DOI Listing
April 2018

A Novel YAP1 Inhibitor Targets CSC-Enriched Radiation-Resistant Cells and Exerts Strong Antitumor Activity in Esophageal Adenocarcinoma.

Mol Cancer Ther 2018 02 22;17(2):443-454. Epub 2017 Nov 22.

Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.

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http://dx.doi.org/10.1158/1535-7163.MCT-17-0560DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5805581PMC
February 2018

Programming of Schwann Cells by Lats1/2-TAZ/YAP Signaling Drives Malignant Peripheral Nerve Sheath Tumorigenesis.

Cancer Cell 2018 02;33(2):292-308.e7

Division of Experimental Hematology and Cancer Biology, Brain Tumor Center, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA; Key Laboratory of Birth Defects, Children's Hospital of Fudan University, Shanghai, China. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2018.01.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5813693PMC
February 2018

Tumor-associated macrophage infiltration is highly associated with PD-L1 expression in gastric adenocarcinoma.

Gastric Cancer 2018 Jan 11;21(1):31-40. Epub 2017 Aug 11.

Department of Gastrointestinal Medical Oncology, Unit 0426, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX, 77030, USA.

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http://dx.doi.org/10.1007/s10120-017-0760-3DOI Listing
January 2018

Hippo pathway coactivators Yap and Taz are required to coordinate mammalian liver regeneration.

Exp Mol Med 2018 01 5;50(1):e423. Epub 2018 Jan 5.

Department of Cancer Biology, University of Texas, MD Anderson Cancer Center, Houston, TX, USA.

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http://dx.doi.org/10.1038/emm.2017.205DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5992983PMC
January 2018

YAP/TAZ and Hedgehog Coordinate Growth and Patterning in Gastrointestinal Mesenchyme.

Dev Cell 2017 10 21;43(1):35-47.e4. Epub 2017 Sep 21.

Department of Molecular, Cell and Cancer Biology, University of Massachusetts Medical School, Worcester, MA 01605, USA. Electronic address:

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http://dx.doi.org/10.1016/j.devcel.2017.08.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5823011PMC
October 2017

The transcriptional coactivator TAZ regulates reciprocal differentiation of T17 cells and T cells.

Nat Immunol 2017 Jul 15;18(7):800-812. Epub 2017 May 15.

State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Xiamen, Fujian, China.

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http://dx.doi.org/10.1038/ni.3748DOI Listing
July 2017

Hippo Signaling Suppresses Cell Ploidy and Tumorigenesis through Skp2.

Cancer Cell 2017 05;31(5):669-684.e7

State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Xiamen, Fujian 361102, China. Electronic address:

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http://dx.doi.org/10.1016/j.ccell.2017.04.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5863541PMC
May 2017

A critical role for NF2 and the Hippo pathway in branching morphogenesis.

Nat Commun 2016 08 2;7:12309. Epub 2016 Aug 2.

Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada M5G 1X5.

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http://dx.doi.org/10.1038/ncomms12309DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4974664PMC
August 2016

An evolutionarily conserved negative feedback mechanism in the Hippo pathway reflects functional difference between LATS1 and LATS2.

Oncotarget 2016 Apr;7(17):24063-75

National Creative Research Center for Cell Division and Differentiation, Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon, South Korea.

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http://dx.doi.org/10.18632/oncotarget.8211DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5029684PMC
April 2016

Inactivation of Hippo Pathway Is Significantly Associated with Poor Prognosis in Hepatocellular Carcinoma.

Clin Cancer Res 2016 Mar 12;22(5):1256-64. Epub 2015 Oct 12.

Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas. Kleberg Center for Molecular Markers, The University of Texas MD Anderson Cancer Center, Houston, Texas. Department of Biochemistry and Molecular Biology, Medical Research Center and Biomedical Science Institute, School of Medicine, Kyung Hee University, Seoul, Korea.

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http://clincancerres.aacrjournals.org/content/early/2015/10/
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http://clincancerres.aacrjournals.org/cgi/doi/10.1158/1078-0
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http://dx.doi.org/10.1158/1078-0432.CCR-15-1447DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5536176PMC
March 2016

Yap is required for ependymal integrity and is suppressed in LPA-induced hydrocephalus.

Nat Commun 2016 Jan 12;7:10329. Epub 2016 Jan 12.

Shriners Hospitals Pediatrics Research Center, Temple University Lewis Katz School of Medicine, Philadelphia, Pennsylvania 19140, USA.

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http://dx.doi.org/10.1038/ncomms10329DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4729961PMC
January 2016

ABT-263 induces apoptosis and synergizes with chemotherapy by targeting stemness pathways in esophageal cancer.

Oncotarget 2015 Sep;6(28):25883-96

Departments of Gastrointestinal Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.

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http://dx.doi.org/10.18632/oncotarget.4540DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4694873PMC
September 2015

AMPK modulates Hippo pathway activity to regulate energy homeostasis.

Nat Cell Biol 2015 Apr 9;17(4):490-9. Epub 2015 Mar 9.

1] Department of Experimental Radiation Oncology, 1515 Holcombe Boulevard Houston, Texas 77030, USA [2] Cancer Biology Program, The University of Texas Graduate School of Biomedical Science, 1515 Holcombe Boulevard Houston, Texas 77030, USA.

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http://dx.doi.org/10.1038/ncb3113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4380807PMC
April 2015

Transcriptional co-repressor function of the hippo pathway transducers YAP and TAZ.

Cell Rep 2015 Apr 2;11(2):270-82. Epub 2015 Apr 2.

National Creative Research Center for Cell Division and Differentiation, Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 305-701, Korea. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2015.03.015DOI Listing
April 2015

Organogenesis special issue - preface.

Dev Dyn 2015 Mar;244(3):225-6

Stowers Institute for Medical Research, Kansas City, Missouri; Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City, Kansas.

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http://dx.doi.org/10.1002/dvdy.24257DOI Listing
March 2015

Integration of Hippo signalling and the unfolded protein response to restrain liver overgrowth and tumorigenesis.

Nat Commun 2015 Feb 19;6:6239. Epub 2015 Feb 19.

State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Xiang'An district, Xiamen, Fujian 361102, China.

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http://dx.doi.org/10.1038/ncomms7239DOI Listing
February 2015

Regulation of YAP by mTOR and autophagy reveals a therapeutic target of tuberous sclerosis complex.

J Exp Med 2014 Oct 6;211(11):2249-63. Epub 2014 Oct 6.

Institut Necker-Enfants Malades, CS 61431, Paris, France Institut National de la Santé et de la Recherche Médicale, U1151, F-75014 Paris, France Université Paris Descartes, Sorbonne Paris Cité, 75006 Paris, France

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http://dx.doi.org/10.1084/jem.20140341DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4203941PMC
October 2014

Metformin sensitizes chemotherapy by targeting cancer stem cells and the mTOR pathway in esophageal cancer.

Int J Oncol 2014 Aug 21;45(2):567-74. Epub 2014 May 21.

Department of Gastrointestinal Medical Oncology, University of Texas M.D. Anderson Cancer Center, Houston, TX, USA.

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http://dx.doi.org/10.3892/ijo.2014.2450DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4091970PMC
August 2014

Downregulation of STRA6 in adipocytes and adipose stromovascular fraction in obesity and effects of adipocyte-specific STRA6 knockdown in vivo.

Mol Cell Biol 2014 Mar 13;34(6):1170-86. Epub 2014 Jan 13.

Division of Endocrinology, Diabetes, and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1128/MCB.01106-13DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3958040PMC
March 2014

Dual function of Yap in the regulation of lens progenitor cells and cellular polarity.

Dev Biol 2014 Feb 31;386(2):281-90. Epub 2013 Dec 31.

Shriners Hospitals Pediatric Research Center and Department of Anatomy and Cell Biology, Temple University School of Medicine, Philadelphia, PA 19140, United States. Electronic address:

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http://dx.doi.org/10.1016/j.ydbio.2013.12.037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3985746PMC
February 2014

Hippo signaling impedes adult heart regeneration.

Development 2013 Dec;140(23):4683-90

Department of Molecular Physiology and Biophysics, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.

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http://dx.doi.org/10.1242/dev.102798DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3833428PMC
December 2013

Bile acids activate YAP to promote liver carcinogenesis.

Cell Rep 2013 Nov 21;5(4):1060-9. Epub 2013 Nov 21.

Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S22111247130061
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http://dx.doi.org/10.1016/j.celrep.2013.10.030DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3961013PMC
November 2013

Metameric pattern of intervertebral disc/vertebral body is generated independently of Mesp2/Ripply-mediated rostro-caudal patterning of somites in the mouse embryo.

Dev Biol 2013 Aug 28;380(2):172-84. Epub 2013 May 28.

Cellular & Molecular Toxicology Division, National Institute of Health Sciences, 1-18-1 Kamiyoga, Setagayaku, Tokyo 158-8501, Japan.

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http://dx.doi.org/10.1016/j.ydbio.2013.05.020DOI Listing
August 2013

Activation of Liver FGF21 in hepatocarcinogenesis and during hepatic stress.

BMC Gastroenterol 2013 Apr 17;13:67. Epub 2013 Apr 17.

Center for Cancer and Stem Cell Biology, Institute of Biosciences and Technology, Texas A&M Health Science Center, 2121 W, Holcombe Blvd,, Houston, TX 77030-3303, USA.

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http://dx.doi.org/10.1186/1471-230X-13-67DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3637159PMC
April 2013

PTHrP regulates the modeling of cortical bone surfaces at fibrous insertion sites during growth.

J Bone Miner Res 2013 Mar;28(3):598-607

Department of Internal Medicine, Yale University, New Haven, CT 06520-2080, USA.

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http://doi.wiley.com/10.1002/jbmr.1801
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http://dx.doi.org/10.1002/jbmr.1801DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3574208PMC
March 2013

Mosaic analysis with double markers reveals cell-type-specific paternal growth dominance.

Cell Rep 2013 Mar 28;3(3):960-7. Epub 2013 Feb 28.

Howard Hughes Medical Institute and Department of Biology, Stanford University, Stanford, CA 94305, USA.

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http://dx.doi.org/10.1016/j.celrep.2013.02.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3668097PMC
March 2013

Hippo signaling regulates pancreas development through inactivation of Yap.

Mol Cell Biol 2012 Dec 15;32(24):5116-28. Epub 2012 Oct 15.

Department of Surgery, University of Nebraska Medical Center, Omaha, Nebraska, USA.

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http://dx.doi.org/10.1128/MCB.01034-12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3510525PMC
December 2012

The transcription factor, Lmx1b, promotes a neuronal glutamate phenotype and suppresses a GABA one in the embryonic trigeminal brainstem complex.

Somatosens Mot Res 2012 7;29(1):1-12. Epub 2012 Mar 7.

Department of Anesthesiology, Center for the Study of Itch, Washington University School of Medicine Pain Center, St Louis, MO 63110, USA.

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http://www.tandfonline.com/doi/full/10.3109/08990220.2011.65
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http://dx.doi.org/10.3109/08990220.2011.650869DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3756596PMC
August 2012

Lmx1a and lmx1b function cooperatively to regulate proliferation, specification, and differentiation of midbrain dopaminergic progenitors.

J Neurosci 2011 Aug;31(35):12413-25

Department of Developmental Neurobiology, National Institute for Medical Research, The Ridgeway, London NW7 1AA, United Kingdom.

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http://dx.doi.org/10.1523/JNEUROSCI.1077-11.2011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6703256PMC
August 2011

Hippo pathway inhibits Wnt signaling to restrain cardiomyocyte proliferation and heart size.

Science 2011 Apr;332(6028):458-61

Institute of Biosciences and Technology, Texas A&M System Health Science Center, 2121 West Holcombe Boulevard, Houston, TX 77030, USA.

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http://dx.doi.org/10.1126/science.1199010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3133743PMC
April 2011

Efficient in vivo doxycycline and cre recombinase-mediated inducible transgene activation in the murine trabecular meshwork.

Invest Ophthalmol Vis Sci 2011 Feb 23;52(2):969-74. Epub 2011 Feb 23.

Department of Biochemistry and Molecular Biology, University of Texas, MD Anderson Cancer Center, Houston, Texas 77030, USA.

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http://iovs.arvojournals.org/article.aspx?doi=10.1167/iovs.0
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http://dx.doi.org/10.1167/iovs.09-5052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3053115PMC
February 2011

Hippo signaling: growth control and beyond.

Development 2011 Jan;138(1):9-22

Department of Biochemistry and Molecular Biology, MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA.

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http://dx.doi.org/10.1242/dev.045500DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2998162PMC
January 2011

Lmx1b is required for murine trabecular meshwork formation and for maintenance of corneal transparency.

Dev Dyn 2010 Aug;239(8):2161-71

Department of Biochemistry and Molecular Biology, University of Texas, MD Anderson Cancer Center, Houston, Texas 77030, USA.

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http://doi.wiley.com/10.1002/dvdy.22347
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http://dx.doi.org/10.1002/dvdy.22347DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5863528PMC
August 2010

Pitx2 prevents susceptibility to atrial arrhythmias by inhibiting left-sided pacemaker specification.

Proc Natl Acad Sci U S A 2010 May 10;107(21):9753-8. Epub 2010 May 10.

Institute of Biosciences and Technology, Texas A&M System Health Science Center, Houston, TX 77030, USA.

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http://dx.doi.org/10.1073/pnas.0912585107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2906838PMC
May 2010

Uncoupling skeletal and connective tissue patterning: conditional deletion in cartilage progenitors reveals cell-autonomous requirements for Lmx1b in dorsal-ventral limb patterning.

Development 2010 Apr;137(7):1181-8

Program in Genes and Development, University of Texas Health Sciences Center, Houston Graduate School of Biomedical Sciences, Houston, TX 77030, USA.

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http://dev.biologists.org/cgi/doi/10.1242/dev.045237
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http://dx.doi.org/10.1242/dev.045237DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2835331PMC
April 2010

Hippo signaling is a potent in vivo growth and tumor suppressor pathway in the mammalian liver.

Proc Natl Acad Sci U S A 2010 Jan 4;107(4):1437-42. Epub 2010 Jan 4.

Department of Biochemistry and Molecular Biology, University of Texas, M. D. Anderson Cancer Center, Houston, TX 77030, USA.

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http://dx.doi.org/10.1073/pnas.0911427107DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2824398PMC
January 2010

Overlapping function of Lmx1a and Lmx1b in anterior hindbrain roof plate formation and cerebellar growth.

J Neurosci 2009 Sep;29(36):11377-84

Committee on Neurobiology and Department of Human Genetics, The University of Chicago, Chicago, Illinois 60637, USA.

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http://dx.doi.org/10.1523/JNEUROSCI.0969-09.2009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2765661PMC
September 2009

Trim24 targets endogenous p53 for degradation.

Proc Natl Acad Sci U S A 2009 Jul 25;106(28):11612-6. Epub 2009 Jun 25.

Department of Biochemistry and Molecular Biology, Program in Genes and Development, Graduate School of Biomedical Sciences and Center for Stem Cell and Developmental Biology, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

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http://dx.doi.org/10.1073/pnas.0813177106DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2710642PMC
July 2009

Manifold functions of the Nail-Patella Syndrome gene Lmx1b in vertebrate development.

Dev Growth Differ 2009 Apr 16;51(3):241-50. Epub 2009 Feb 16.

Institute of Neuroscience, State Key Laboratory of Neuroscience, Chinese Academy of Sciences, Shanghai 200031, China.

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http://dx.doi.org/10.1111/j.1440-169X.2008.01083.xDOI Listing
April 2009

Lmx1b-controlled isthmic organizer is essential for development of midbrain dopaminergic neurons.

J Neurosci 2008 Dec;28(52):14097-106

Institute of Neuroscience, Key Laboratory of Neurobiology, Chinese Academy of Sciences, Shanghai 200031, China.

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http://dx.doi.org/10.1523/JNEUROSCI.3267-08.2008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6671480PMC
December 2008

Renal phenotype in heterozygous Lmx1b knockout mice (Lmx1b+/-) after unilateral nephrectomy.

Transgenic Res 2007 Dec 27;16(6):723-9. Epub 2007 Jul 27.

Institute of Human Genetics, Friedrich-Alexander University Erlangen-Nuremberg, University Hospital Erlangen, Schwabachanlage 10, 91054 Erlangen, Germany.

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http://dx.doi.org/10.1007/s11248-007-9118-7DOI Listing
December 2007

Lmx1b is essential for Fgf8 and Wnt1 expression in the isthmic organizer during tectum and cerebellum development in mice.

Development 2007 Jan 13;134(2):317-25. Epub 2006 Dec 13.

Institute of Neuroscience and Key Laboratory of Neurobiology, Shanghai Institute for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China.

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http://dev.biologists.org/content/develop/134/2/317.full.pdf
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http://dev.biologists.org/cgi/doi/10.1242/dev.02745
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http://dx.doi.org/10.1242/dev.02745DOI Listing
January 2007

Mutant myocilin nonsecretion in vivo is not sufficient to cause glaucoma.

Mol Cell Biol 2006 Nov 5;26(22):8427-36. Epub 2006 Sep 5.

The Jackson Laboratory, Bar Harbor, ME 04609, USA.

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http://dx.doi.org/10.1128/MCB.01127-06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1636791PMC
November 2006

HESR1/CHF2 suppresses VEGFR2 transcription independent of binding to E-boxes.

Biochem Biophys Res Commun 2006 Aug 8;346(3):637-48. Epub 2006 Jun 8.

Department of Molecular Biology and Biochemistry, University of California Irvine, Irvine, CA 92697, USA.

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http://dx.doi.org/10.1016/j.bbrc.2006.05.177DOI Listing
August 2006

Targeted disruption of the DM domain containing transcription factor Dmrt2 reveals an essential role in somite patterning.

Dev Biol 2006 Feb 4;290(1):200-10. Epub 2006 Jan 4.

Department of Biochemistry and Molecular Biology, University of Texas, MD Anderson Cancer Center, Houston, 77030, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S001216060500817
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http://dx.doi.org/10.1016/j.ydbio.2005.11.027DOI Listing
February 2006

Gene expression profiles in developing nephrons using Lim1 metanephric mesenchyme-specific conditional mutant mice.

BMC Nephrol 2006 Feb 7;7. Epub 2006 Feb 7.

Department of Molecular Genetics, University of Texas M. D. Anderson Cancer Center, Houston, Texas 77030, USA.

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http://bmcnephrol.biomedcentral.com/articles/10.1186/1471-23
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http://dx.doi.org/10.1186/1471-2369-7-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1413522PMC
February 2006

Hesr, a mediator of the Notch signaling, functions in heart and vessel development.

Trends Cardiovasc Med 2005 Jul;15(5):190-4

Division of Mammalian Development, National Institute of Genetics, Yata 1111, Mishima 411-8540, Japan.

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http://dx.doi.org/10.1016/j.tcm.2005.05.005DOI Listing
July 2005

A neurological phenotype in nail patella syndrome (NPS) patients illuminated by studies of murine Lmx1b expression.

Eur J Hum Genet 2005 Mar;13(3):330-5

McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University, Baltimore MD 21205, USA.

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http://dx.doi.org/10.1038/sj.ejhg.5201332DOI Listing
March 2005

Lmx1b controls the differentiation and migration of the superficial dorsal horn neurons of the spinal cord.

Development 2004 Aug 30;131(15):3693-703. Epub 2004 Jun 30.

Departments of Anesthesiology, Psychiatry, Molecular Biology and Pharmacology, Washington University School of Medicine Pain Center, St. Louis, MO 63110, USA.

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http://dev.biologists.org/cgi/doi/10.1242/dev.01250
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August 2004

Lmx1b expression during joint and tendon formation: localization and evaluation of potential downstream targets.

Gene Expr Patterns 2004 Jul;4(4):397-405

Department of Pathology and Human Anatomy, Loma Linda University, 24785 Stewart St., Loma Linda, CA 92350, USA.

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http://dx.doi.org/10.1016/j.modgep.2004.01.006DOI Listing
July 2004

Lmx1b is essential for the development of serotonergic neurons.

Nat Neurosci 2003 Sep;6(9):933-8

Department of Anesthesiology, School of Medicine Pain Center, Washington University, St. Louis, Missouri 63110, USA.

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http://dx.doi.org/10.1038/nn1104DOI Listing
September 2003

Functional genetic analysis of mouse chromosome 11.

Nature 2003 Sep;425(6953):81-6

Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA.

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http://dx.doi.org/10.1038/nature01865DOI Listing
September 2003

Interactions between dorsal-ventral patterning genes lmx1b, engrailed-1 and wnt-7a in the vertebrate limb.

Int J Dev Biol 2002 ;46(7):937-41

Program in Genes and Development, Department of Biochemistry and Molecular Biology, University of Texas, MD Anderson Cancer Center, Houston 77030, USA.

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June 2003

The expression patterns of c-kit and Sl in chicken embryos suggest unexpected roles for these genes in somite and limb development.

Gene Expr Patterns 2003 Mar;3(1):53-8

Section of Molecular and Cellular Biology, University of California at Davis, Davis, CA 95616, USA.

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March 2003

The LIM-homeodomain transcription factor Lmx1b plays a crucial role in podocytes.

J Clin Invest 2002 Apr;109(8):1073-82

Institute for Anatomy and Cell Biology I, University of Heidelberg, Im Neuenheimer Feld 307, 69120 Heidelberg, Germany.

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http://dx.doi.org/10.1172/JCI13961DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC150943PMC
April 2002