Publications by authors named "Randie Kim"

52 Publications

White Piedra.

JAMA Dermatol 2021 Jan 20. Epub 2021 Jan 20.

The Ronald O. Perelman Department of Dermatology, New York University School of Medicine, New York.

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http://dx.doi.org/10.1001/jamadermatol.2020.4266DOI Listing
January 2021

Dabrafenib-induced neutrophilic panniculitis in a child undergoing dual BRAF-MEK inhibitor therapy for glioblastoma multiforme.

Pediatr Dermatol 2020 Nov 1;37(6):1185-1186. Epub 2020 Sep 1.

The Ronald O. Perelman Department of Dermatology, New York University Grossman School of Medicine, New York, New York, USA.

BRAF inhibitor-induced neutrophilic panniculitis is a rare event that is well-characterized in adults undergoing therapy for metastatic melanoma. To date, there are very few reports of this event in children undergoing BRAF inhibitor therapy for low-grade gliomas, all of which were seen with vemurafenib. We report a case of dabrafenib-induced neutrophilic panniculitis in a 9-year-old girl that manifested within several weeks of initiating dual BRAF-MEK inhibitor therapy for glioblastoma multiforme. This case highlights neutrophilic panniculitis as a side effect of dabrafenib in children and serves as a reminder to consider cutaneous side effects of BRAF inhibitors as they are increasingly used to treat children with primary brain tumors.
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http://dx.doi.org/10.1111/pde.14306DOI Listing
November 2020

Dermatopathology education during the COVID-19 pandemic: Virtual simulation of the multiheaded microscope.

J Am Acad Dermatol 2020 09 1;83(3):e243-e244. Epub 2020 Jun 1.

The Ronald O. Perelman Department of Dermatology, New York University Grossman School of Medicine, New York, New York.

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http://dx.doi.org/10.1016/j.jaad.2020.05.127DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7262529PMC
September 2020

Characterizing index keratinocytic carcinomas in commercially insured adults younger than age 50 years in the United States.

J Am Acad Dermatol 2020 Nov 8;83(5):1458-1460. Epub 2020 Mar 8.

The Ronald O. Perelman Department of Dermatology, New York University Grossman School of Medicine, New York. Electronic address:

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http://dx.doi.org/10.1016/j.jaad.2020.02.074DOI Listing
November 2020

Nevus psiloliparus: Newly described histopathological features from transverse sections.

J Cutan Pathol 2020 Jul 16;47(7):633-637. Epub 2020 Feb 16.

The Ronald O. Perelman Department of Dermatology, New York University Grossman School of Medicine, New York, New York.

Nevus psiloliparus is a rare fatty tissue nevus that is a marker for encephalocraniocutaneous lipomatosis, a neurocutaneous syndrome with ocular and central nervous system anomalies. Clinically, nevus psiloliparus is often described as a congenital alopecia and appears as an irregularly shaped, circumscribed area of alopecia on the scalp. Histopathology demonstrates a near-complete absence of mature hair follicles with preservation of arrector pili muscles and mature adipocytes within the dermis. The pathogenesis of nevus psiloliparus may be related to mosaic mutations in fibroblast growth factor receptor 1. Herein we report the histopathological features of a nevus psiloliparus in an 11-year-old girl diagnosed from transverse sections, which show "shadow" follicular units characterized by columns of loosely arranged collagen and a relative paucity of elastic fibers.
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http://dx.doi.org/10.1111/cup.13663DOI Listing
July 2020

A persistent dermal hypersensitivity reaction associated with infection.

JAAD Case Rep 2020 Feb 30;6(2):156-158. Epub 2020 Jan 30.

Department of Dermatology, State University of New York Downstate Medical Center, Brooklyn, New York.

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http://dx.doi.org/10.1016/j.jdcr.2019.11.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6997649PMC
February 2020

Practical Direct Immunofluorescence.

Am J Dermatopathol 2020 Feb;42(2):75-85

Associate Professor, The Ronald O. Perelman Department of Dermatology, New York University School of Medicine, New York, NY.

Direct immunofluorescence (DIF) remains a valuable tool that may be underused because of perceived challenges in the interpretation, limitations, and processing of DIF specimens. The aim of this review is to provide a practical guide for appropriately incorporating DIF in a variety of clinical diseases, such as autoimmune blistering disorders. In vasculitis, the role of DIF continues to evolve, particularly in the setting of IgA vasculitis. Although typically not indicated for the workup of connective tissue disease, DIF may be helpful in cases with negative serologies, nondiagnostic histologic findings, or scarring alopecia. Practical pearls for biopsy technique, specimen handling, and storage are also discussed.
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http://dx.doi.org/10.1097/DAD.0000000000001516DOI Listing
February 2020

Psoriasis prevalence in the United States in a commercial insurance claims database: 2011-2017.

J Am Acad Dermatol 2020 01 6;82(1):229-230. Epub 2019 Jun 6.

Ronald O. Perelman Department of Dermatology, New York University School of Medicine, New York, New York. Electronic address:

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http://dx.doi.org/10.1016/j.jaad.2019.05.092DOI Listing
January 2020

Eosinophilic Fasciitis With Concomitant Morphea Profunda Treated With Intravenous Immunoglobulin.

J Clin Rheumatol 2019 Oct 29. Epub 2019 Oct 29.

The Ronald O. Perelman Department of Dermatology New York University School of Medicine New York, NY

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http://dx.doi.org/10.1097/RHU.0000000000001158DOI Listing
October 2019

The diminishing presence of dermatologists in the care of hospitalized patients receiving Medicare benefits.

J Am Acad Dermatol 2020 Aug 2;83(2):640-643. Epub 2019 Nov 2.

The Ronald O. Perelman Department of Dermatology, New York University, New York. Electronic address:

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http://dx.doi.org/10.1016/j.jaad.2019.10.061DOI Listing
August 2020

Atypical Findings in Adult-Onset Still Disease.

J Clin Rheumatol 2020 Dec;26(8):e281-e283

From The Ronald O. Perelman Department of Dermatology, New York University School of Medicine, New York, NY.

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http://dx.doi.org/10.1097/RHU.0000000000001129DOI Listing
December 2020

Lichen Planus Follicularis Tumidus Associated With PD-1 Blockade.

JAMA Dermatol 2019 Jul 31. Epub 2019 Jul 31.

The Ronald O. Perelman Department of Dermatology, New York University School of Medicine, New York.

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http://dx.doi.org/10.1001/jamadermatol.2019.1676DOI Listing
July 2019

In response to, “How I learned to stop worrying and love machine learning”.

Authors:
Randie H Kim

Clin Dermatol 2019 May - Jun;37(3):291-292. Epub 2019 Feb 14.

The Ronald O. Perelman Department of Dermatology, New York University School of Medicine, New York, New York, USA. Electronic address:

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http://dx.doi.org/10.1016/j.clindermatol.2019.02.001DOI Listing
October 2019

Necrobiosis lipoidica.

Dermatol Online J 2018 Dec 15;24(12). Epub 2018 Dec 15.

The Ronald O. Perelman Department of Dermatology, New York University School of Medicine, New York, New York.

We present a case of necrobiosis lipoidica (NL) of the right abdomen in a 75-year-old man. A skin biopsy performed showed a layered infiltrate of mono and multinucleated histiocytes palisaded around degenerated collagen bundles. Laboratory workup was unremarkable. The patient was treated with topical corticosteroids with cessation of progression of his disease, although the eruption did not resolve. There are a number of treatments for NL reported in the literature, all with varying efficacy. Although NL lesions are usually asymptomatic, patients with NL must be monitored closely for signs of ulceration or malignant transformation, in which case more aggressive treatment options may be warranted.
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December 2018

Mirtazapine-induced hyperpigmentation with type II histopathologic findings.

JAAD Case Rep 2018 Nov 14;4(10):1077-1079. Epub 2018 Nov 14.

Ronald O. Perelman Department of Dermatology, NYU Langone Health, New York, New York.

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http://dx.doi.org/10.1016/j.jdcr.2018.09.022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6250903PMC
November 2018

Primary Melanoma Histologic Subtype: Impact on Survival and Response to Therapy.

J Natl Cancer Inst 2019 02;111(2):180-188

Department of Medicine.

Background: Two primary histologic subtypes, superficial spreading melanoma (SSM) and nodular melanoma (NM), comprise the majority of all cutaneous melanomas. NM is associated with worse outcomes, which have been attributed to increased thickness at presentation, and it is widely expected that NM and SSM would exhibit similar behavior once metastasized. Herein, we tested the hypothesis that primary histologic subtype is an independent predictor of survival and may impact response to treatment in the metastatic setting.

Methods: We examined the most recent Surveillance, Epidemiology, and End Results (SEER) cohort (n = 118 508) and the New York University (NYU) cohort (n = 1621) with available protocol-driven follow-up. Outcomes specified by primary histology were studied in both the primary and metastatic settings with respect to BRAF-targeted therapy and immunotherapy. We characterized known driver mutations and examined a 140-gene panel in a subset of NM and SSM cases using next-generation sequencing. All statistical tests were two-sided.

Results: NM was an independent risk factor for death in both the SEER (hazard ratio [HR] = 1.55, 95% confidence interval [CI] = 1.41 to 1.70, P < .001) and NYU (HR = 1.47, 95% CI = 1.05, 2.07, P = .03) cohorts, controlling for thickness, ulceration, stage, and other variables. In the metastatic setting, NM remained an independent risk factor for death upon treatment with BRAF-targeted therapy (HR = 3.33, 95% CI = 1.06 to 10.47, P = .04) but showed no statistically significant difference with immune checkpoint inhibition. NM was associated with a higher rate of NRAS mutation (P < .001), and high-throughput sequencing revealed NM-specific genomic alterations in NOTCH4, ANK3, and ZNF560, which were independently validated.

Conclusions: Our data reveal distinct clinical and biological differences between NM and SSM that support revisiting the prognostic and predictive impact of primary histology subtype in the management of cutaneous melanoma.
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http://dx.doi.org/10.1093/jnci/djy086DOI Listing
February 2019

Concentric targetoid scaly plaques in a patient with severe rheumatoid arthritis.

Int J Dermatol 2018 Aug 11;57(8):913-914. Epub 2018 Apr 11.

The Ronald O. Perelman Department of Dermatology, New York University School of Medicine, New York, NY, USA.

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http://dx.doi.org/10.1111/ijd.13991DOI Listing
August 2018

Primary anetoderma with undifferentiated connective tissue disease.

Dermatol Online J 2017 Dec 15;23(12). Epub 2017 Dec 15.

New York University Health, New York.

Anetoderma is a rare benign elastolytic disorder that is characterized by focal loss of elastin fibers on histopathology and is often recalcitrant to treatment. We present a case of a patient with a 20-year history of pruritic and painful hyperpigmented atrophic papules clustered on the neck, axillae, inframammary folds, and right medial thigh. Although the histopathologyof her axillary lesions was consistent with anetoderma, her clinical presentation is unusual given the extent of involvement, reported pain and pruritus, and sharp demarcation of the distribution. The diagnosticuncertainty of this case led to added difficulty in management of a disease that is already notoriously difficult to treat and may significantly impact patient's quality of life.
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December 2017

Generalized hyperhidrosis secondary to presumed eccrine gland dysfunction with possible apocrine metaplasia.

Dermatol Online J 2017 Dec 15;23(12). Epub 2017 Dec 15.

New York University Health, New York.

We present a 57 year-old man presented with generalized hyperhidrosis and widespread, smooth, flesh colored papules on the torso and extremities.Histological examination from multiple biopsies demonstrated morphologic alteration of the eccrine glands with an apocrine phenotype, suggesting eitherapocrine metaplasia or the presence of "apoeccrine glands." The morphologic similarities between eccrine, apocrine, and apoeccrine as they relate to ourpatient's histologic findings are discussed. We consider secondary causes of generalized hyperhidrosis, which may also play a role in this patient's presentation. Treatment and further workup are discussed, whilemanagement of this patient remains in progress.
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December 2017

Papular mucinosis, or localized lichen myxedematosis (LM) (discrete papular type).

Dermatol Online J 2017 Dec 15;23(12). Epub 2017 Dec 15.

New York University Langone Health, New York.

Lichen myxedematosus is condition characterized by localized areas of dermal deposition of mucin, presenting with firm papules localized to few areas of the body. The condition needs to be excluded from scleromyxedema, which, in addition to the firm papular eruption, has areas of induration and is usually associated with a monoclonal gammopathyand systemic symptoms. We present a 62-year-old woman with a several-year history of asymptomatic, firm papules over the face and arms with no evidence of thyroid disease or a monoclonal gammopathy,which is consistent with a diagnosis of localized lichen myxedematosus, the discrete papular variant. The patient is being treated with a topical calcineurininhibitor.
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December 2017

An immunosuppressed man with an isolated necrotic plaque on the chest.

JAAD Case Rep 2018 Mar 12;4(2):114-116. Epub 2018 Jan 12.

The Ronald O. Perelman Department of Dermatology, New York University School of Medicine, New York, New York.

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http://dx.doi.org/10.1016/j.jdcr.2017.02.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5767909PMC
March 2018

The Legacy of the Radium Girls.

JAMA Dermatol 2017 08;153(8):801

The Ronald O. Perelman Department of Dermatology, New York University School of Medicine, New York, New York.

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http://dx.doi.org/10.1001/jamadermatol.2017.2576DOI Listing
August 2017

Novel use of apremilast for adjunctive treatment of recalcitrant pyoderma gangrenosum.

JAAD Case Rep 2017 May 14;3(3):228-229. Epub 2017 Apr 14.

Ronald O. Perelman Department of Dermatology, New York University School of Medicine, New York, New York.

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http://dx.doi.org/10.1016/j.jdcr.2017.02.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5394202PMC
May 2017

Immunostain use in the diagnosis of melanomas referred to a tertiary medical center: a 15-year retrospective review (2001-2015).

J Cutan Pathol 2017 Mar 23;44(3):221-227. Epub 2016 Dec 23.

Dermatopathology Section, The Ronald O. Perelman Department of Dermatology, New York University School of Medicine, New York, NY, USA.

Background: Little is known regarding the clinical practice of immunohistochemistry in the diagnosis of melanoma. We aimed to assess the incidence of immunostain usage by referring pathologists and dermatopathologists in melanoma cases sent for consultative review. As a secondary objective, associations between immunostain use and specific melanoma characteristics were also evaluated.

Methods: This is a retrospective review of consultation reports of referred melanomas at a tertiary academic center in New York, NY from 2001 to 2015. Univariate regression analysis was performed on melanomas with accompanying immunostains and on characteristics such as Breslow's depth, location, prognostic factors and morphologic subtypes. Associations between immunostain usage and these characteristics were analyzed using Fisher's exact test.

Results: Immunostain use significantly increased over the study period (p < 0.001) and was more likely to be associated with melanomas that were thicker [odds ratio (OR) = 2.5; 1.7-3.6]; located on the head and neck (OR = 1.6; 1.4-1.9) or acral sites (OR = 1.5; 1.1-2.0); had ulceration (OR = 2.1; 1.6-2.8), dermal mitoses (OR = 1.3; 1.1-1.5), or perineural invasion (OR = 3.6; 2.0-6.5); or were of desmoplastic (OR = 7.4; 4.5-12), amelanotic (OR = 7.1; 3.6-14), or nevoid subtypes (OR = 4.0; 1.7-8.9).

Conclusions: Immunostain use in the diagnosis of melanoma has increased significantly in the past 15 years for reasons that remain unclear.
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http://dx.doi.org/10.1111/cup.12867DOI Listing
March 2017

Universal immunohistochemical screening of sebaceous neoplasms for Muir-Torre syndrome: Putting the cart before the horse?

J Am Acad Dermatol 2016 Nov;75(5):1078-1079

Ronald O. Perelman Department of Dermatology, New York University School of Medicine, New York, New York. Electronic address:

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http://dx.doi.org/10.1016/j.jaad.2016.07.053DOI Listing
November 2016

Metastatic Cutaneous Squamous Cell Carcinoma: The Importance of T2 Stratification and Hematologic Malignancy in Prognostication.

Dermatol Surg 2016 Aug;42(8):932-5

*The Ronald O. Perelman Department of Dermatology, New York University Langone Medical Center, New York, New York; †Laura and Isaac Perlmutter Cancer Center, New York University Langone Medical Center, New York, New York.

Background: While infrequent, nodal metastases in cutaneous squamous cell carcinoma (cSCC) can result in death from disease. Identification of those at risk for metastases is key to improved prognostication and treatment.

Objective: To review metastatic cSCC at the study institution.

Methods And Materials: Sixteen patients with metastatic cSCC were identified at the New York University Dermatologic Associates and Cancer Associates from 1998 to 2013. Patients were staged with American Joint Committee on Cancer (AJCC) and modified Brigham and Women's Hospital (BWH) criteria and compared to 32 control subjects.

Results: Seven of 16 patients were identified as Stage T2 by AJCC criteria and Stage T2b by BWH criteria; two patients were on Stage T1, three patients were on more advanced T stages, and four patients lacked primary tumor data. Five patients had hematologic malignancy, and one patient had a solid-organ transplant.

Conclusion: The modified BWH criteria aims to better prognosticate the large group of T2 AJCC tumors, resulting in the majority of mortality. In the experience of the authors, the majority of patients with metastatic disease were on T2, stratifying to stage T2b by BWH criteria, or more advanced T stages. The findings of this study support BWH stratification of T2 tumors and also indicate that hematologic malignancy is a significant comorbidity associated with a poor outcome.
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http://dx.doi.org/10.1097/DSS.0000000000000798DOI Listing
August 2016

Giant acquired reactive perforating collagenosis in a patient with diabetes mellitus and metastatic breast carcinoma.

JAAD Case Rep 2016 Jan 14;2(1):22-4. Epub 2016 Jan 14.

The Ronald O. Perelman Department of Dermatology, New York University School of Medicine, New York, New York.

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http://dx.doi.org/10.1016/j.jdcr.2015.11.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4809472PMC
January 2016

Frontal fibrosing alopecia in a 46-year-old man.

Dermatol Online J 2016 Dec 15;22(12). Epub 2016 Dec 15.

Ronald O. Perelman Department of Dermatology, NYU School of Medicine, NYU Langone Medical Center.

Frontal fibrosing alopecia is a scarring alopecia thatis characterized by recession of the frontotemporalhairline with the frequent loss of eyebrows. Itpredominantly affects postmenopausal womenand only rarely affects men. We report the caseof a 46-year-old man with a ten-year history of anerythematous patch with perifollicular erythemaat the superior aspect of the forehead andfrontotemporal hairline. A skin biopsy specimenshowed a perivascular, lymphocytic infiltrate withperiinfundibular fibrosis. These findings establisheda diagnosis of frontal fibrosing alopecia. Thepathogenesis of this condition is poorly understoodbut may be hormonally-mediated.
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December 2016

Sarcoidosis with prominent necrosis on histopathology.

Dermatol Online J 2016 Dec 15;22(12). Epub 2016 Dec 15.

Ronald O. Perelman Department of Dermatology, NYU School of Medicine, NYU Langone Medical Center.

Sarcoidosis is a multiorgan inflammatory diseasewith variable clinical presentations and the commonhistopathologic finding of noncaseating granulomas.The etiology of the disease is not known, butevidence suggests both environmental and geneticcontributions to the pathogenesis. Depending onthe severity of cutaneous disease and extent ofextracutaneous involvement, therapies range fromtopical and intralesional glucocorticoids to systemicimmunomodulatory and immunosuppressiveagents. We present the case of a patient withcutaneous sarcoidosis with prominent necrosis onhistopathologic examination in the setting of severepulmonary sarcoidosis.
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December 2016

Lichen planus pigmentosus and lichen planopilaris.

Dermatol Online J 2016 Dec 15;22(12). Epub 2016 Dec 15.

Ronald O. Perelman Department of Dermatology, NYU School of Medicine, NYU Langone Medical Center.

Lichen planus is an inflammatory skin conditionwith characteristic histopathological findings thathas many clinical variants. Recently, there have been25 cases reported in the literature of lichen planuspigmentosus (LPPi) that preceded the developmentof frontal fibrosing alopecia (FFA), which is a variantof lichen planopilaris (LPP). We review the literatureregarding LPPi, LPP, and FFA and present a case of a40-year-old African American woman with LPPi andLPP.
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December 2016