Randall T Peterson

Randall T Peterson

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Randall T Peterson

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The zebrafish subcortical social brain as a model for studying social behavior disorders.

Dis Model Mech 2019 Aug 6;12(8). Epub 2019 Aug 6.

Department of Pharmacology and Toxicology, College of Pharmacy, University of Utah, 30 S. 2000 East, Salt Lake City, UT 84112, USA

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http://dx.doi.org/10.1242/dmm.039446DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6737945PMC
August 2019

Stable, Reactive, and Orthogonal Tetrazines: Dispersion Forces Promote the Cycloaddition with Isonitriles.

Angew Chem Int Ed Engl 2019 Jul 6;58(27):9043-9048. Epub 2019 Jun 6.

Department of Medicinal Chemistry, University of Utah, 30 S 2000 E, Salt Lake City, UT, 84112, USA.

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http://dx.doi.org/10.1002/anie.201903877DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6615965PMC
July 2019

Developing zebrafish disease models for in vivo small molecule screens.

Curr Opin Chem Biol 2019 Jun 28;50:37-44. Epub 2019 Mar 28.

College of Pharmacy, University of Utah, Salt Lake City, UT 84112, United States. Electronic address:

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http://dx.doi.org/10.1016/j.cbpa.2019.02.005DOI Listing
June 2019

5-Nitrofurans and Cancer: Teaching an Old Drug New Tricks.

Cell Chem Biol 2018 12;25(12):1439-1440

Department of Pharmacology and Toxicology, College of Pharmacy, University of Utah, Salt Lake City, UT 84112, USA. Electronic address:

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http://dx.doi.org/10.1016/j.chembiol.2018.12.005DOI Listing
December 2018

Small Molecule Inhibitors of NFkB Reverse Iron Overload and Hepcidin Deregulation in a Zebrafish Model for Hereditary Hemochromatosis Type 3.

ACS Chem Biol 2018 08 28;13(8):2143-2152. Epub 2018 Jun 28.

CSIR-Institute of Genomics and Integrative Biology , New Delhi , 110025 , India.

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http://dx.doi.org/10.1021/acschembio.8b00317DOI Listing
August 2018

Bioorthogonal Removal of 3-Isocyanopropyl Groups Enables the Controlled Release of Fluorophores and Drugs in Vivo.

J Am Chem Soc 2018 07 27;140(27):8410-8414. Epub 2018 Jun 27.

Department of Medicinal Chemistry, College of Pharmacy , University of Utah , 30 S 2000 E , Salt Lake City , Utah 84112 , United States.

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http://dx.doi.org/10.1021/jacs.8b05093DOI Listing
July 2018

Chemical Screening in Zebrafish.

Methods Mol Biol 2016 ;1451:3-16

Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, 149 13th Street, Charlestown, MA, 02129, USA.

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http://dx.doi.org/10.1007/978-1-4939-3771-4_1DOI Listing
January 2018

Development of an opioid self-administration assay to study drug seeking in zebrafish.

Behav Brain Res 2017 09 12;335:158-166. Epub 2017 Aug 12.

Department of Pharmacology and Toxicology,University of Utah, Salt Lake City, UT 84112, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bbr.2017.08.001DOI Listing
September 2017

A high-conductance chemo-optogenetic system based on the vertebrate channel Trpa1b.

Sci Rep 2017 09 19;7(1):11839. Epub 2017 Sep 19.

Cardiovascular Research Center, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, 02129, USA.

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http://dx.doi.org/10.1038/s41598-017-11791-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5605526PMC
September 2017

Bonnevillamides, Linear Heptapeptides Isolated from a Great Salt Lake-Derived Streptomyces sp.

Mar Drugs 2017 Jun 24;15(7). Epub 2017 Jun 24.

Department of Medicinal Chemistry, University of Utah, Salt Lake City, UT 84112, USA.

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http://dx.doi.org/10.3390/md15070195DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5532637PMC
June 2017

Cisplatin Analogs Confer Protection against Cyanide Poisoning.

Cell Chem Biol 2017 May 13;24(5):565-575.e4. Epub 2017 Apr 13.

Division of Cardiology, Department of Medicine, Cardiovascular Research Center, Massachusetts General Hospital, Charlestown, MA 02129, USA; Department of Systems Biology, Harvard Medical School, Boston, MA 02215, USA; Broad Institute, Cambridge, MA 02142, USA. Electronic address:

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http://dx.doi.org/10.1016/j.chembiol.2017.03.013DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5472353PMC
May 2017

Loss of vhl in the zebrafish pronephros recapitulates early stages of human clear cell renal cell carcinoma.

Dis Model Mech 2016 08;9(8):873-84

Center for Cancer Research, Massachusetts General Hospital, Boston, MA 02114, USA Department of Medicine, Harvard Medical School, Boston, MA 02115, USA Division of Hematology-Oncology, Department of Medicine, Massachusetts General Hospital, Boston, MA 02142, USA

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http://dx.doi.org/10.1242/dmm.024380DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5007981PMC
August 2016

A countermeasure development pipeline.

Ann N Y Acad Sci 2016 08;1378(1):58-67

Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1111/nyas.13224DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6420827PMC
August 2016

A Small Molecule that Induces Intrinsic Pathway Apoptosis with Unparalleled Speed.

Cell Rep 2015 Dec 19;13(9):2027-36. Epub 2015 Nov 19.

Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2015.10.042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4683402PMC
December 2015

Zebrafish as tools for drug discovery.

Nat Rev Drug Discov 2015 Oct 11;14(10):721-31. Epub 2015 Sep 11.

Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1038/nrd4627DOI Listing
October 2015

Engineered CRISPR-Cas9 nucleases with altered PAM specificities.

Nature 2015 Jul 22;523(7561):481-5. Epub 2015 Jun 22.

1] Molecular Pathology Unit &Center for Cancer Research, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA [2] Center for Computational and Integrative Biology, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA [3] Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1038/nature14592DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4540238PMC
July 2015

15 years of zebrafish chemical screening.

Curr Opin Chem Biol 2015 Feb 15;24:58-70. Epub 2014 Nov 15.

Cardiovascular Research Center and Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, 149 13th Street, Charlestown, MA 02129, USA; Department of Systems Biology, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA; Broad Institute, 7 Cambridge Center, Cambridge, MA 02142, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cbpa.2014.10.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4339096PMC
February 2015

PTPMT1 Inhibition Lowers Glucose through Succinate Dehydrogenase Phosphorylation.

Cell Rep 2015 Feb 5;10(5):694-701. Epub 2015 Feb 5.

Cardiovascular Research Center and Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA; Broad Institute, Cambridge, MA 02142, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2015.01.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4524786PMC
February 2015

Methods for targeted mutagenesis in zebrafish using TALENs.

Methods 2014 Aug 18;69(1):76-84. Epub 2014 Apr 18.

Cardiovascular Research Center, Massachusetts General Hospital, 149 13th street, Room 4201, Charlestown, MA 02129, USA; Department of Medicine, Harvard Medical School, 25 Shattuck St, Boston, MA 02115, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ymeth.2014.04.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4157959PMC
August 2014

A zebrafish model of chordoma initiated by notochord-driven expression of HRASV12.

Dis Model Mech 2014 Jul 5;7(7):907-13. Epub 2013 Dec 5.

Cancer Center, Massachusetts General Hospital, Charlestown, MA 02129, USA. Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA.

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http://dx.doi.org/10.1242/dmm.013128DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4073279PMC
July 2014

The zebrafish as a tool to identify novel therapies for human cardiovascular disease.

Dis Model Mech 2014 Jul;7(7):763-7

Massachusetts General Hospital Cardiovascular Research Center, Harvard Medical School, Charlestown, MA 02129, USA.

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http://dmm.biologists.org/content/dmm/7/7/763.full.pdf
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http://dmm.biologists.org/cgi/doi/10.1242/dmm.016170
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http://dx.doi.org/10.1242/dmm.016170DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4073266PMC
July 2014

Zebrafish models of cerebrovascular disease.

J Cereb Blood Flow Metab 2014 Apr 12;34(4):571-7. Epub 2014 Feb 12.

1] Cardiovascular Research Center, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts, USA [2] Broad Institute, Cambridge, Massachusetts, USA.

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http://dx.doi.org/10.1038/jcbfm.2014.27DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3982096PMC
April 2014

Heritable and precise zebrafish genome editing using a CRISPR-Cas system.

PLoS One 2013 9;8(7):e68708. Epub 2013 Jul 9.

Cardiovascular Research Center, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0068708PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3706373PMC
February 2014

Induced and sustained hypernatremia for the prevention and treatment of cerebral edema following brain injury.

Neurocrit Care 2013 Oct;19(2):222-31

Department of Neurosurgery, Massachusetts General Hospital and Harvard Medical School, 55 Fruit Street, White Building Room 502, Boston, MA, 02114, USA.

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http://link.springer.com/10.1007/s12028-013-9824-3
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http://dx.doi.org/10.1007/s12028-013-9824-3DOI Listing
October 2013

Photochemical activation of TRPA1 channels in neurons and animals.

Nat Chem Biol 2013 Apr 10;9(4):257-63. Epub 2013 Feb 10.

Department of Medicine, Cardiovascular Research Center and Division of Cardiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA.

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http://dx.doi.org/10.1038/nchembio.1183DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3604056PMC
April 2013

Efficient genome editing in zebrafish using a CRISPR-Cas system.

Nat Biotechnol 2013 Mar 29;31(3):227-9. Epub 2013 Jan 29.

Cardiovascular Research Center, Massachusetts General Hospital, Charlestown, Massachusetts, USA.

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http://dx.doi.org/10.1038/nbt.2501DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3686313PMC
March 2013

An in vivo zebrafish screen identifies organophosphate antidotes with diverse mechanisms of action.

J Biomol Screen 2013 Jan 6;18(1):108-15. Epub 2012 Sep 6.

Massachusetts General Hospital, Harvard Medical School, Department of Medicine, Charlestown, MA, USA.

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http://dx.doi.org/10.1177/1087057112458153DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4053346PMC
January 2013

From phenotype to mechanism after zebrafish small molecule screens.

Drug Discov Today Dis Models 2013 ;10(1):e51-e55

Cardiovascular Research Center and Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, 149 13 Street, Charlestown, Massachusetts 02129, USA. Broad Institute, 7 Cambridge Center, Cambridge Massachusetts 02124, USA.

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http://dx.doi.org/10.1016/j.ddmod.2012.02.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4489146PMC
January 2013

Changing the Scale and Efficiency of Chemical Warfare Countermeasure Discovery Using the Zebrafish.

Drug Discov Today Dis Models 2013 ;10(1)

Harvard Medical School, Massachusetts General Hospital, Brigham and Women's Hospital.

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http://dx.doi.org/10.1016/j.ddmod.2013.05.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3834265PMC
January 2013

AUTOMATED QUANTIFICATION OF ZEBRAFISH TAIL DEFORMATION FOR HIGH-THROUGHPUT DRUG SCREENING.

Proc IEEE Int Symp Biomed Imaging 2013 :902-905

Centre for Image Analysis/SciLifeLab, Uppsala University, Sweden ; Broad Institute of Harvard and MIT, Cambridge, MA.

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http://dx.doi.org/10.1109/ISBI.2013.6556621DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3909804PMC
January 2013

Highly efficient generation of heritable zebrafish gene mutations using homo- and heterodimeric TALENs.

Nucleic Acids Res 2012 Sep 7;40(16):8001-10. Epub 2012 Jun 7.

Cardiovascular Research Center, Massachusetts General Hospital, Department of Medicine, Harvard Medical School, Charlestown, MA 02129, USA.

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http://dx.doi.org/10.1093/nar/gks518DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3439908PMC
September 2012

Behavioral barcoding in the cloud: embracing data-intensive digital phenotyping in neuropharmacology.

Trends Biotechnol 2012 Aug 29;30(8):421-5. Epub 2012 May 29.

Cardiovascular Research Center and Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, 149 13th Street, Charlestown, MA 02129, USA.

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http://dx.doi.org/10.1016/j.tibtech.2012.05.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3401323PMC
August 2012

New mechanisms of 5-nitrofuran toxicity.

Chem Biol 2012 Jul;19(7):789-90

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http://dx.doi.org/10.1016/j.chembiol.2012.07.001DOI Listing
July 2012

Systematic approaches to toxicology in the zebrafish.

Annu Rev Pharmacol Toxicol 2012 19;52:433-53. Epub 2011 Oct 19.

Harvard Medical School, Massachusetts General Hospital, and Brigham and Women's Hospital, Boston, Massachusetts 02115, USA.

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http://www.annualreviews.org/doi/10.1146/annurev-pharmtox-01
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http://dx.doi.org/10.1146/annurev-pharmtox-010611-134751DOI Listing
May 2012

Apoptotic cells are cleared by directional migration and elmo1- dependent macrophage engulfment.

Curr Biol 2012 May 12;22(9):830-6. Epub 2012 Apr 12.

Cardiovascular Research Center and Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA.

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http://dx.doi.org/10.1016/j.cub.2012.03.027DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3597770PMC
May 2012

Engineering zinc finger nucleases for targeted mutagenesis of zebrafish.

Methods Cell Biol 2011 ;104:51-8

Molecular Pathology Unit, Center for Computational and Integrative Biology, and Center for Cancer Research, Massachusetts General Hospital, Charlestown, Massachusetts, USA.

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http://dx.doi.org/10.1016/B978-0-12-374814-0.00003-3DOI Listing
January 2012

Using the zebrafish photomotor response for psychotropic drug screening.

Methods Cell Biol 2011 ;105:517-24

Cardiovascular Research Center and Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA.

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https://linkinghub.elsevier.com/retrieve/pii/B97801238132060
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http://dx.doi.org/10.1016/B978-0-12-381320-6.00022-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3635141PMC
January 2012

Designing zebrafish chemical screens.

Methods Cell Biol 2011 ;105:525-41

Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA.

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http://dx.doi.org/10.1016/B978-0-12-381320-6.00023-0DOI Listing
January 2012

Perturbation of hepcidin expression by BMP type I receptor deletion induces iron overload in mice.

Blood 2011 Oct 12;118(15):4224-30. Epub 2011 Aug 12.

Anesthesia Center for Critical Care Research of the Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1182/blood-2011-03-339952DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3204739PMC
October 2011

Dehydro-alpha-lapachone, a plant product with antivascular activity.

Proc Natl Acad Sci U S A 2011 Jul 27;108(28):11596-601. Epub 2011 Jun 27.

Edwin L. Steele Laboratory, Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.

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http://dx.doi.org/10.1073/pnas.1104225108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3136298PMC
July 2011

Novel chemical suppressors of long QT syndrome identified by an in vivo functional screen.

Circulation 2011 Jan 15;123(1):23-30. Epub 2010 Nov 15.

Cardiovascular Research Center and Cardiac Arrhythmia Service, Massachusetts General Hospital, 149 13th St, Charlestown, MA 02129, USA.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.110.003731DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3015011PMC
January 2011

cables1 is required for embryonic neural development: molecular, cellular, and behavioral evidence from the zebrafish.

Mol Reprod Dev 2011 Jan 23;78(1):22-32. Epub 2010 Dec 23.

Vincent Center for Reproductive Biology, MGH Vincent Department of Obstetrics and Gynecology, Massachusetts General Hospital, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1002/mrd.21263DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4016823PMC
January 2011

Live imaging of apoptotic cells in zebrafish.

FASEB J 2010 Nov 2;24(11):4336-42. Epub 2010 Jul 2.

Cardiovascular Research Center, Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA.

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http://dx.doi.org/10.1096/fj.10-161018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2974414PMC
November 2010

Small molecule screening in zebrafish.

J Cardiovasc Transl Res 2010 Oct 3;3(5):454-60. Epub 2010 Aug 3.

Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, 149 13th Street, Charlestown, MA 02129, USA.

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http://dx.doi.org/10.1007/s12265-010-9212-8DOI Listing
October 2010

Assessing prostate cancer growth with mRNA of spermine metabolic enzymes.

Cancer Biol Ther 2010 May 18;9(9):736-42. Epub 2010 May 18.

Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.4161/cbt.9.9.11549DOI Listing
May 2010

A forward chemical screen in zebrafish identifies a retinoic acid derivative with receptor specificity.

PLoS One 2010 Apr 2;5(4):e10004. Epub 2010 Apr 2.

Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, New York, New York, USA.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0010004PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2848850PMC
April 2010

Targeted mutagenesis in zebrafish using customized zinc-finger nucleases.

Nat Protoc 2009 ;4(12):1855-67

Molecular Pathology Unit and Center for Cancer Research, Massachusetts General Hospital, Charlestown, Massachusetts, USA.

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http://dx.doi.org/10.1038/nprot.2009.209DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2814337PMC
March 2010

Rapid behavior-based identification of neuroactive small molecules in the zebrafish.

Nat Chem Biol 2010 Mar 17;6(3):231-237. Epub 2010 Jan 17.

[1] Cardiovascular Research Center and Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA. [2] Broad Institute, Cambridge, Massachusetts, USA.

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http://dx.doi.org/10.1038/nchembio.307DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2834185PMC
March 2010

Drug discovery: Propping up a destructive regime.

Nature 2009 Oct;461(7264):599-600

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http://dx.doi.org/10.1038/461599aDOI Listing
October 2009

Systematizing serendipity for cardiovascular drug discovery.

Circulation 2009 Jul;120(3):255-63

Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA 02129, USA.

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https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.108.8
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http://dx.doi.org/10.1161/CIRCULATIONAHA.108.824177DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2756982PMC
July 2009

Discovering chemical modifiers of oncogene-regulated hematopoietic differentiation.

Nat Chem Biol 2009 Apr 26;5(4):236-43. Epub 2009 Jan 26.

Developmental Biology Laboratory, Cardiovascular Research Center, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA.

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http://dx.doi.org/10.1038/nchembio.147DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2658727PMC
April 2009

Rapid mutation of endogenous zebrafish genes using zinc finger nucleases made by Oligomerized Pool ENgineering (OPEN).

PLoS One 2009 9;4(2):e4348. Epub 2009 Feb 9.

Molecular Pathology Unit, Center for Cancer Research, and Center for Computational and Integrative Biology, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0004348PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2634973PMC
April 2009

Novel Wnt antagonists target porcupine and Axin.

Nat Chem Biol 2009 Feb;5(2):74-5

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http://dx.doi.org/10.1038/nchembio0209-74DOI Listing
February 2009

Chemobehavioural phenomics and behaviour-based psychiatric drug discovery in the zebrafish.

Brief Funct Genomic Proteomic 2008 Nov 10;7(6):483-90. Epub 2008 Sep 10.

Cardiovascular Research Center and Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, 149 13th Street, Charlestown, MA 02129, USA.

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http://dx.doi.org/10.1093/bfgp/eln040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2722257PMC
November 2008

Chemical biology and the limits of reductionism.

Nat Chem Biol 2008 Nov;4(11):635-8

Massachusetts General Hospital, Harvard Medical School, 149 13th Street, Charlestown, Massachusetts 02129, USA.

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http://dx.doi.org/10.1038/nchembio1108-635DOI Listing
November 2008

Role of crosstalk between phosphatidylinositol 3-kinase and extracellular signal-regulated kinase/mitogen-activated protein kinase pathways in artery-vein specification.

Circ Res 2008 Sep;103(6):573-9

Division of Cardiovascular Medicine, Vanderbilt University Medical Center, 383 PRB, 2220 Pierce Ave, Nashville, TN 37232, USA.

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http://dx.doi.org/10.1161/CIRCRESAHA.108.180745DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2768581PMC
September 2008

Structure-activity relationship study of bone morphogenetic protein (BMP) signaling inhibitors.

Bioorg Med Chem Lett 2008 Aug 27;18(15):4388-92. Epub 2008 Jun 27.

Laboratory for Drug Discovery in Neurodegeneration, Harvard NeuroDiscovery Center, Brigham & Women's Hospital and Harvard Medical School, 65 Landsdowne Street, Cambridge, MA 02139, USA.

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http://dx.doi.org/10.1016/j.bmcl.2008.06.052DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2570262PMC
August 2008

Dorsomorphin, a selective small molecule inhibitor of BMP signaling, promotes cardiomyogenesis in embryonic stem cells.

PLoS One 2008 Aug 6;3(8):e2904. Epub 2008 Aug 6.

Department of Medicine, Division of Cardiovascular Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0002904PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2483414PMC
August 2008

Deciphering arterial identity through gene expression, genetics, and chemical biology.

Curr Opin Hematol 2008 May;15(3):221-7

Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA.

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http://dx.doi.org/10.1097/MOH.0b013e3282f97daaDOI Listing
May 2008

Use of non-mammalian alternative models for neurotoxicological study.

Neurotoxicology 2008 May 25;29(3):546-55. Epub 2008 Apr 25.

Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.

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http://dx.doi.org/10.1016/j.neuro.2008.04.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2702842PMC
May 2008

Loss of TLE1 and TLE4 from the del(9q) commonly deleted region in AML cooperates with AML1-ETO to affect myeloid cell proliferation and survival.

Blood 2008 Apr 7;111(8):4338-47. Epub 2008 Feb 7.

Department of Pediatrics, Division of Pediatric Hematology/Oncology, Massachusetts General Hospital, and Harvard Medical School, Boston, MA 02114, USA.

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http://dx.doi.org/10.1182/blood-2007-07-103291DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2288729PMC
April 2008

Identification of a novel retinoid by small molecule screening with zebrafish embryos.

PLoS One 2008 Apr 9;3(4):e1947. Epub 2008 Apr 9.

Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0001947PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2275795PMC
April 2008

Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolism.

Nat Chem Biol 2008 Jan 18;4(1):33-41. Epub 2007 Nov 18.

Cardiovascular Research Center and Division of Cardiology, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, 149 13th Street, Charlestown, Massachusetts 02129, USA.

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http://www.nature.com/articles/nchembio.2007.54
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http://dx.doi.org/10.1038/nchembio.2007.54DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2727650PMC
January 2008

AML1-ETO reprograms hematopoietic cell fate by downregulating scl expression.

Development 2008 Jan;135(2):401-10

Developmental Biology Laboratory, Cardiovascular Research Center, Massachusetts General Hospital, Charlestown, MA 02129, USA.

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http://dx.doi.org/10.1242/dev.008904DOI Listing
January 2008

Unraveling tissue regeneration pathways using chemical genetics.

J Biol Chem 2007 Nov 11;282(48):35202-10. Epub 2007 Sep 11.

Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, Oregon 97331, USA.

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http://dx.doi.org/10.1074/jbc.M706640200DOI Listing
November 2007

A Rap GTPase interactor, RADIL, mediates migration of neural crest precursors.

Genes Dev 2007 Sep 17;21(17):2131-6. Epub 2007 Aug 17.

Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, Massachusetts 02129, USA.

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http://dx.doi.org/10.1101/gad.1561507DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1950852PMC
September 2007

A noncanonical path to mechanism of action.

Chem Biol 2006 Sep;13(9):924-6

Cardiovascular Research Center, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, USA.

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http://dx.doi.org/10.1016/j.chembiol.2006.09.002DOI Listing
September 2006

Artery/vein specification is governed by opposing phosphatidylinositol-3 kinase and MAP kinase/ERK signaling.

Curr Biol 2006 Jul;16(13):1366-72

Developmental Biology Laboratory, Cardiovascular Research Center, Massachusetts General Hospital, Charlestown, Massachusetts 02129, and Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S096098220601629
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http://dx.doi.org/10.1016/j.cub.2006.05.046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1930149PMC
July 2006