Randal R Ketchem

Randal R Ketchem

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Randal R Ketchem

Randal R Ketchem

Publications by authors named "Randal R Ketchem"

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Anti-PCSK9 antibody pharmacokinetics and low-density lipoprotein-cholesterol pharmacodynamics in nonhuman primates are antigen affinity-dependent and exhibit limited sensitivity to neonatal Fc receptor-binding enhancement.

J Pharmacol Exp Ther 2015 Apr 4;353(1):119-31. Epub 2015 Feb 4.

Departments of Pharmacokinetics and Drug Metabolism (K.R.H., K.C.M., M.W.R.), Metabolic Disorders (B.A., J.C.Y.C., S.M.J.), Therapeutic Discovery (M.H., W.W., J.S., J.H., J.T., C.K., D.E.P., R.R.K., M.L.M.), Molecular Sciences (R.X.), and Biostatistics (L.Z.), Amgen, South San Francisco, California.

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http://jpet.aspetjournals.org/cgi/doi/10.1124/jpet.114.22124
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http://dx.doi.org/10.1124/jpet.114.221242DOI Listing
April 2015

ADAM8 as a drug target in pancreatic cancer.

Nat Commun 2015 Jan 28;6:6175. Epub 2015 Jan 28.

1] King's College London, Institute for Pharmaceutical Science and KCLDI, London SE1 9RT, UK [2] Department of Neurosurgery, Marburg University, , Baldingerstrasse, 35033 Marburg, Germany.

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http://dx.doi.org/10.1038/ncomms7175DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5014123PMC
January 2015

Entanglement model of antibody viscosity.

J Phys Chem B 2014 May 2;118(19):5044-9. Epub 2014 May 2.

Department of Physics, Kansas State University , Manhattan, Kansas 66506, United States.

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http://dx.doi.org/10.1021/jp500434bDOI Listing
May 2014

Small-angle neutron scattering study of a monoclonal antibody using free-energy constraints.

J Phys Chem B 2013 Nov 31;117(45):14029-38. Epub 2013 Oct 31.

NIST Center for Neutron Research, National Institute of Standards and Technology , 100 Bureau Drive, Mail Stop 6102, Gaithersburg, Maryland 20899, United States.

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http://dx.doi.org/10.1021/jp408710rDOI Listing
November 2013

Native-state solubility and transfer free energy as predictive tools for selecting excipients to include in protein formulation development studies.

J Pharm Sci 2012 Aug 30;101(8):2720-32. Epub 2012 May 30.

Department of Drug Product Development, Amgen Inc., Seattle, Washington 98119-3105, USA.

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http://dx.doi.org/10.1002/jps.23219DOI Listing
August 2012

Chemical modifications in therapeutic protein aggregates generated under different stress conditions.

J Biol Chem 2011 Jul 25;286(28):25134-44. Epub 2011 Apr 25.

Department of Analytical and Formulation Sciences, Amgen Inc., Thousand Oaks, California 91320, USA.

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http://dx.doi.org/10.1074/jbc.M110.160440DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3137086PMC
July 2011

Diverse functions of reactive cysteines facilitate unique biosynthetic processes of aggregate-prone interleukin-31.

Exp Cell Res 2011 Apr 21;317(7):976-93. Epub 2010 Dec 21.

Department of Protein Science, Amgen Inc, Seattle, WA 98119, USA.

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http://dx.doi.org/10.1016/j.yexcr.2010.12.012DOI Listing
April 2011

Histidine residue mediates radical-induced hinge cleavage of human IgG1.

J Biol Chem 2010 Jun 19;285(24):18662-71. Epub 2010 Mar 19.

Department of Analytical and Formulation Science, Amgen Inc., Seattle, Washington 98119, USA.

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http://dx.doi.org/10.1074/jbc.M110.108597DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2881791PMC
June 2010

A diversity of antibody epitopes can induce signaling through the erythropoietin receptor.

Biochemistry 2010 May;49(18):3797-804

Amgen, Inc., 1201 Amgen Court West AW2/3152, Seattle, Washington 98119-3105, USA.

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http://dx.doi.org/10.1021/bi1001147DOI Listing
May 2010

A role for the MHC class I-like Mill molecules in nutrient metabolism and wound healing.

Immunol Cell Biol 2008 Aug-Sep;86(6):489-96. Epub 2008 Jun 17.

The Department of Oncology, Amgen Washington, Seattle, WA, USA.

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http://doi.wiley.com/10.1038/icb.2008.41
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http://dx.doi.org/10.1038/icb.2008.41DOI Listing
October 2008

Disulfide connectivity of human immunoglobulin G2 structural isoforms.

Biochemistry 2008 Jul 13;47(28):7496-508. Epub 2008 Jun 13.

Department of Analytical and Formulation Sciences, Process and Product Development, Amgen, Inc., Seattle, Washington 98119, USA.

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http://dx.doi.org/10.1021/bi800576cDOI Listing
July 2008

Electrophoretic evidence for the presence of structural isoforms specific for the IgG2 isotype.

Electrophoresis 2008 Jun;29(12):2550-6

Department of Analytical and Formulation Sciences, Amgen Inc., Seattle, WA, USA.

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http://dx.doi.org/10.1002/elps.200800083DOI Listing
June 2008