Randal N Johnston

Randal N Johnston

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Randal N Johnston

Randal N Johnston

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Distinct evolutionary origins of common multi-drug resistance phenotypes in Salmonella typhimurium DT104: a convergent process for adaptation under stress.

Mol Genet Genomics 2019 Jun 1;294(3):597-605. Epub 2019 Feb 1.

Systemomics Center, College of Pharmacy, and Genomics Research Center, Harbin Medical University, 157 Baojian Road, Harbin, 150081, China.

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http://dx.doi.org/10.1007/s00438-019-01531-5DOI Listing
June 2019

Going (Reo)Viral: Factors Promoting Successful Reoviral Oncolytic Infection.

Viruses 2018 08 11;10(8). Epub 2018 Aug 11.

Department of Biochemistry and Molecular Biology, Cumming School of Medicine, University of Calgary, Calgary, AB T2N 4N1, Canada.

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http://dx.doi.org/10.3390/v10080421DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6116061PMC
August 2018

Increased EGFR expression induced by a novel oncogene, CUG2, confers resistance to doxorubicin through Stat1-HDAC4 signaling.

Cell Oncol (Dordr) 2017 Dec 3;40(6):549-561. Epub 2017 Aug 3.

BK21+, Department of Cogno-Mechatronics Engineering, Pusan National University, Busan, 46241, Republic of Korea.

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http://dx.doi.org/10.1007/s13402-017-0343-7DOI Listing
December 2017

Main components of pomegranate, ellagic acid and luteolin, inhibit metastasis of ovarian cancer by down-regulating MMP2 and MMP9.

Cancer Biol Ther 2017 Dec 27;18(12):990-999. Epub 2017 Nov 27.

a Systemomics Center, College of Pharmacy, and Genomics Research Center (State-Province Key Laboratories of Biomedicine-Pharmaceutics of China) , Harbin Medical University , Harbin , Heilongjiang Province , China.

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https://www.tandfonline.com/doi/full/10.1080/15384047.2017.1
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http://dx.doi.org/10.1080/15384047.2017.1394542DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5718784PMC
December 2017

Anti-tumor efficacy of oncolytic reovirus against gastrointestinal stromal tumor cells.

Oncotarget 2017 Dec 18;8(70):115632-115646. Epub 2017 Dec 18.

Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Mizuho-Ku, Nagoya, Japan.

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http://dx.doi.org/10.18632/oncotarget.23361DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5777799PMC
December 2017

Differential degeneration of the ACTAGT sequence among Salmonella: a reflection of distinct nucleotide amelioration patterns during bacterial divergence.

Sci Rep 2017 09 8;7(1):10985. Epub 2017 Sep 8.

Systemomics Center, College of Pharmacy, and Genomics Research Center (State-Province Key Laboratories of Biomedicine-Pharmaceutics of China), Harbin Medical University, Harbin, China.

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http://dx.doi.org/10.1038/s41598-017-11226-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5591236PMC
September 2017

Enterolactone has stronger effects than enterodiol on ovarian cancer.

J Ovarian Res 2017 Jul 24;10(1):49. Epub 2017 Jul 24.

Systemomics Center, College of Pharmacy, and Genomics Research Center (State-Province Key Laboratories of Biomedicine-Pharmaceutics of China), Harbin Medical University, Harbin, 150081, China.

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http://dx.doi.org/10.1186/s13048-017-0346-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5525236PMC
July 2017

Conserved intergenic sequences revealed by CTAG-profiling in Salmonella: thermodynamic modeling for function prediction.

Sci Rep 2017 03 6;7:43565. Epub 2017 Mar 6.

Systemomics Center, College of Pharmacy, and Genomics Research Center (State-Province Key Laboratories of Biomedicine-Pharmaceutics of China), Harbin Medical University, Harbin, China.

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http://dx.doi.org/10.1038/srep43565DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5337935PMC
March 2017

Biobanking in the Twenty-First Century: Driving Population Metrics into Biobanking Quality.

Adv Exp Med Biol 2015 ;864:95-114

Department of Cancer Epidemiology and Prevention Research, CancerControl Alberta, Alberta Health Services, Calgary, Canada.

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http://dx.doi.org/10.1007/978-3-319-20579-3_8DOI Listing
March 2016

Potential for Improving Potency and Specificity of Reovirus Oncolysis with Next-Generation Reovirus Variants.

Viruses 2015 Dec 1;7(12):6251-78. Epub 2015 Dec 1.

Department of Medical Microbiology and Immunology, University of Alberta, Edmonton, AB T6G 2E1, Canada.

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http://www.mdpi.com/1999-4915/7/12/2936
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http://dx.doi.org/10.3390/v7122936DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4690860PMC
December 2015

CTAG-containing cleavage site profiling to delineate Salmonella into natural clusters.

PLoS One 2014 19;9(8):e103388. Epub 2014 Aug 19.

Genomics Research Center (one of The State-Province Key Laboratories of Biomedicine-Pharmaceutics of China), Harbin Medical University, Harbin, China; Department of Biopharmaceutical Sciences, Harbin Medical University, Harbin, China; HMU-UCFM Centre for Infection and Genomics, Harbin Medical University, Harbin, China; Department of Microbiology and Infectious Diseases, University of Calgary, Calgary, Canada; Department of Infectious Diseases of First Affiliated Hospital, Harbin Medical University, Harbin, China.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0103388PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4138082PMC
October 2015

Complete genome sequence of Salmonella enterica subspecies arizonae str. RKS2983.

Stand Genomic Sci 2015 3;10:30. Epub 2015 Jun 3.

Genomics Research Center, Harbin Medical University, Harbin, China ; Department of Infectious Diseases, The First Affiliated Hospital, Harbin Medical University, Harbin, China ; Department of Microbiology, Immunology and Infectious Diseases, University of Calgary, Calgary, Canada.

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http://dx.doi.org/10.1186/s40793-015-0015-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4511000PMC
July 2015

Upregulation of Stat1-HDAC4 confers resistance to etoposide through enhanced multidrug resistance 1 expression in human A549 lung cancer cells.

Mol Med Rep 2015 Mar 14;11(3):2315-21. Epub 2014 Nov 14.

BK21+, Department of Cogno‑Mechatronics Engineering, Pusan National University, Busan 609‑735, Republic of Korea.

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http://dx.doi.org/10.3892/mmr.2014.2949DOI Listing
March 2015

Oncolytic reovirus combined with trastuzumab enhances antitumor efficacy through TRAIL signaling in human HER2-positive gastric cancer cells.

Cancer Lett 2015 Jan 17;356(2 Pt B):846-54. Epub 2014 Nov 17.

Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Mizuho-ku, Nagoya 467-8601, Japan.

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http://dx.doi.org/10.1016/j.canlet.2014.10.046DOI Listing
January 2015

Biobank bootstrapping: is biobank sustainability possible through cost recovery?

Biopreserv Biobank 2014 Dec;12(6):374-80

1 Ontario Tumour Bank, Ontario Institute for Cancer Research , Toronto, Ontario, Canada .

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http://dx.doi.org/10.1089/bio.2014.0051DOI Listing
December 2014

Differential efficiency in exogenous DNA acquisition among closely related Salmonella strains: implications in bacterial speciation.

BMC Microbiol 2014 Jun 14;14:157. Epub 2014 Jun 14.

Genomics Research Center (one of The State-Province Key Laboratories of Biomedicine-Pharmaceutics of China), Harbin Medical University, 157 Baojian Road, Harbin 150081, China.

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http://dx.doi.org/10.1186/1471-2180-14-157DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4094785PMC
June 2014

Suppression of autophagic genes sensitizes CUG2-overexpressing A549 human lung cancer cells to oncolytic vesicular stomatitis virus-induced apoptosis.

Int J Oncol 2014 Apr 21;44(4):1177-84. Epub 2014 Jan 21.

BK21+, Department of Cogno-Mechatronics Engineering, Pusan National University, Busan 609-735, Republic of Korea.

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http://dx.doi.org/10.3892/ijo.2014.2264DOI Listing
April 2014

Feroniellin A-induced autophagy causes apoptosis in multidrug-resistant human A549 lung cancer cells.

Int J Oncol 2014 Apr 11;44(4):1233-42. Epub 2014 Feb 11.

BK21+, Department of Cogno-Mechatronics Engineering, Pusan National University, Busan 609-735, Republic of Korea.

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http://dx.doi.org/10.3892/ijo.2014.2297DOI Listing
April 2014

Genomic comparison of Salmonella typhimurium DT104 with non-DT104 strains.

Mol Genet Genomics 2013 Nov 11;288(11):549-57. Epub 2013 Aug 11.

Genomics Research Center (one of The State-Province Key Laboratories of Biomedicine-Pharmaceutics of China), Harbin Medical University, 157 Baojian Road, 150081, Harbin, China.

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http://dx.doi.org/10.1007/s00438-013-0762-8DOI Listing
November 2013

Double-deleted vaccinia virus in virotherapy for refractory and metastatic pediatric solid tumors.

Mol Oncol 2013 Oct 14;7(5):944-54. Epub 2013 Jun 14.

Pediatric Oncology Experimental Therapeutics Investigators Consortium (POETIC) Laboratory for Pre-Clinical and Drug Discovery Studies, University of Calgary, Canada and Division of Pediatric Oncology, Alberta Children's Hospital, Calgary, Alberta, Canada.

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http://dx.doi.org/10.1016/j.molonc.2013.05.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5528451PMC
October 2013

Characterization of the defects in the ATP lid of E. coli MutL that cause transient hypermutability.

DNA Repair (Amst) 2013 Oct 2;12(10):864-9. Epub 2013 Aug 2.

Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON, Canada.

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http://dx.doi.org/10.1016/j.dnarep.2013.07.003DOI Listing
October 2013

Cancer upregulated gene 2, a novel oncogene, enhances migration and drug resistance of colon cancer cells via STAT1 activation.

Int J Oncol 2013 Oct 5;43(4):1111-6. Epub 2013 Aug 5.

WCU, Department of Cogno-Mechatronics Engineering, Pusan National University, Busan 609-735, Republic of Korea.

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http://dx.doi.org/10.3892/ijo.2013.2049DOI Listing
October 2013

Genetic boundaries to delineate the typhoid agent and other Salmonella serotypes into distinct natural lineages.

Genomics 2013 Oct 6;102(4):331-7. Epub 2013 Aug 6.

Genomics Research Center (one of The State-Province Key Laboratories of Biomedicine-Pharmaceutics of China), Harbin Medical University, Harbin, China.

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http://dx.doi.org/10.1016/j.ygeno.2013.07.014DOI Listing
October 2013

Genomic comparison between Salmonella Gallinarum and Pullorum: differential pseudogene formation under common host restriction.

PLoS One 2013 15;8(3):e59427. Epub 2013 Mar 15.

Genomics Research Center (one of The State-Province Key Laboratories of Biomedicine-Pharmaceutics of China), Harbin Medical University, Harbin, China.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0059427PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3598799PMC
September 2013

The type VI secretion system gene cluster of Salmonella typhimurium: required for full virulence in mice.

J Basic Microbiol 2013 Jul 7;53(7):600-7. Epub 2012 Sep 7.

Genomics Research Center, Harbin, China.

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http://dx.doi.org/10.1002/jobm.201200047DOI Listing
July 2013

Defining natural species of bacteria: clear-cut genomic boundaries revealed by a turning point in nucleotide sequence divergence.

BMC Genomics 2013 Jul 18;14:489. Epub 2013 Jul 18.

Genomics Research Center, The State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Harbin, China.

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http://dx.doi.org/10.1186/1471-2164-14-489DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3751360PMC
July 2013

Genomic compartmentalization of gene families encoding core components of metazoan signaling systems.

Genome 2013 Apr 1;56(4):215-25. Epub 2013 Apr 1.

Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Calgary, Calgary AB T2N 4N1, Canada.

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http://dx.doi.org/10.1139/gen-2013-0021DOI Listing
April 2013

Inheritance of the Salmonella virulence plasmids: mostly vertical and rarely horizontal.

Infect Genet Evol 2012 Jul 23;12(5):1058-63. Epub 2012 Mar 23.

Genomics Research Center, The State-Province Key Laboratories of Biomedicine-Pharmaceutics, Harbin Medical University, Harbin, China.

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http://dx.doi.org/10.1016/j.meegid.2012.03.004DOI Listing
July 2012

Up-regulation of Foxo4 mediated by hepatitis B virus X protein confers resistance to oxidative stress-induced cell death.

Int J Mol Med 2011 Aug 11;28(2):255-60. Epub 2011 May 11.

WCU Department of Cogno-Mechatronics Engineering, BK21 Nanofusion Technology Team, Pusan National University, Busan, Republic of Korea.

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http://dx.doi.org/10.3892/ijmm.2011.699DOI Listing
August 2011

Z-FA-FMK as a novel potent inhibitor of reovirus pathogenesis and oncolysis in vivo.

Antivir Ther 2010 ;15(6):897-905

Department of Biochemistry and Molecular Biology, University of Calgary, AB, Canada.

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http://dx.doi.org/10.3851/IMP1646DOI Listing
December 2010

SPC-P1: a pathogenicity-associated prophage of Salmonella paratyphi C.

BMC Genomics 2010 Dec 30;11:729. Epub 2010 Dec 30.

Department of Microbiology, Peking University Health Science Center, Beijing, PR China.

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http://dx.doi.org/10.1186/1471-2164-11-729DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3022927PMC
December 2010

Multiple genetic switches spontaneously modulating bacterial mutability.

BMC Evol Biol 2010 Sep 13;10:277. Epub 2010 Sep 13.

Genomics Research Center (one of The State-Province Key Laboratories of Biomedicine-Pharmaceutics of China), Harbin Medical University, Harbin, China.

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http://dx.doi.org/10.1186/1471-2148-10-277DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2955026PMC
September 2010

Reovirus infection induces apoptosis of TRAIL-resistant gastric cancer cells by down-regulation of Akt activation.

Int J Oncol 2010 Apr;36(4):1023-30

Department of Cogno-Mechatronics Engineering, BK21 Nanofusion Technology Team, Pusan National University, Busan 609-735, Korea.

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April 2010

Inhibition of GSK-3beta enhances reovirus-induced apoptosis in colon cancer cells.

Int J Oncol 2009 Sep;35(3):617-24

Department of Nanomedical Engineering, BK21 Nanofusion Technology Team, Pusan National University, Miryang, Gyeongnam, Korea.

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September 2009

Hexachlorophene suppresses beta-catenin expression by up-regulation of Siah-1 in EBV-infected B lymphoma cells.

Cancer Lett 2009 Apr 16;276(2):136-42. Epub 2008 Dec 16.

Department of Nanomedical Engineering, BK21 Nanofusion Technology Team, Pusan National University, Miryang, Gyeongnam, Republic of Korea.

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https://linkinghub.elsevier.com/retrieve/pii/S03043835080087
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http://dx.doi.org/10.1016/j.canlet.2008.10.041DOI Listing
April 2009

Diverse genome structures of Salmonella paratyphi C.

BMC Genomics 2007 Aug 27;8:290. Epub 2007 Aug 27.

Microbiology, Peking University Health Science Center, Beijing, China.

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http://dx.doi.org/10.1186/1471-2164-8-290DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2000905PMC
August 2007

Reovirus and tumor oncolysis.

J Microbiol 2007 Jun;45(3):187-92

Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada.

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June 2007

Genome plasticity and ori-ter rebalancing in Salmonella typhi.

Mol Biol Evol 2006 Feb 19;23(2):365-71. Epub 2005 Oct 19.

Department of Microbiology, Peking University Health Science Center, Beijing, China.

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http://dx.doi.org/10.1093/molbev/msj042DOI Listing
February 2006

Altered subcellular localization and low frequency of mutations of ING1 in human brain tumors.

Clin Cancer Res 2003 Dec;9(16 Pt 1):5952-61

Department of Medical Biochemistry and Southern Alberta Cancer Research Center, The University of Calgary, Calgary, Alberta, Canada.

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December 2003

Genomic diversification among archival strains of Salmonella enterica serovar typhimurium LT7.

J Bacteriol 2003 Apr;185(7):2131-42

Department of Microbiology and Infectious Diseases, University of Calgary, Calgary, T2N 4N1 Alberta, Canada.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC151480PMC
http://dx.doi.org/10.1128/jb.185.7.2131-2142.2003DOI Listing
April 2003

Human ING1 proteins differentially regulate histone acetylation.

J Biol Chem 2002 Aug 15;277(33):29832-9. Epub 2002 May 15.

Department of Biochemistry, University of Calgary, Calgary, Alberta T2N 4N1, Canada.

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http://dx.doi.org/10.1074/jbc.M200197200DOI Listing
August 2002

The evolving genome of Salmonella enterica serovar Pullorum.

J Bacteriol 2002 May;184(10):2626-33

Department of Microbiology and Infectious Diseases, University of Calgary, 3330 Hospital Drive NW, Calgary, Alberta T2N 4N1, Canada.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC135040PMC
http://dx.doi.org/10.1128/jb.184.10.2626-2633.2002DOI Listing
May 2002