Publications by authors named "Ran Bi"

61 Publications

Case report of the treatment and experience of mental disorders due to chronic viral encephalitis.

Gen Psychiatr 2021 13;34(1):e100340. Epub 2021 Jan 13.

Department of Sleep Disorders, Affiliated Psychological Hospital of Anhui Medical University, Hefei, Anhui, China.

Viral encephalitis is a common clinical condition. Its clinical manifestations are variable and include neurological symptoms and psychiatric abnormalities, which makes clinical diagnosis and treatment difficult. To date, there are only a few reported cases on mental symptoms of chronic viral encephalitis. We present a case of a 16-year-old male patient who was previously hospitalised and diagnosed with schizophrenia and treated with aripiprazole 15 mg/day but failed to respond. The patient was then given antiviral therapy and recovered after 2 weeks. Clinicians should be aware of the possbility that chronic mental disorders could be caused by viral encephalitis. In the future, diagnosis of chronic functional mental disorders should include viral encephalitis in the differential diagnosis.
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http://dx.doi.org/10.1136/gpsych-2020-100340DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7812080PMC
January 2021

Quercetin alleviates acute kidney injury by inhibiting ferroptosis.

J Adv Res 2021 Feb 22;28:231-243. Epub 2020 Jul 22.

Center for New Drug Safety Evaluation and Research, State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, Jiangsu 211198, PR China.

Introduction: Ferroptosis is an iron-dependent regulated necrosis and has been proven to contribute to the progress of acute kidney injury (AKI). Quercetin (QCT), a natural flavonoid which is commonly found in numerous fruits and vegetables, has extensive pharmacological effects, such as anti-oxidant, anti-inflammatory and anti-senescence effects.

Objectives: This study aims to explain whether ferroptosis is a therapeutic strategy to AKI, and to explore the effect of QCT on AKI ferroptosis.

Methods: NRK-52E cells and HK-2 cells were used for in vitro ferroptosis studies. Morphology of cells was detected by transmission electron microscopy. Lipid ROS was assayed using flow cytometry. In vivo, AKI was induced by ischemia-reperfusion (I/R) or folic acid (FA). To explore the molecular mechanisms, RNA-sequence analysis was performed. Transwell was used to detect macrophage migration.

Results: We discovered that quercetin (QCT), a natural flavonoid, inhibited ferroptosis in renal proximal tubular epithelial cells. QCT blocked the typical morphologic changes of ferroptotic cells by reducing the levels of malondialdehyde (MDA) and lipid ROS and increasing the levels of glutathione (GSH). Moreover, QCT ameliorated AKI induced by I/R or FA. RNA-sequence analysis highlighted activation transcription factor 3 (ATF3), as it was the dominant one among all the 299 down-regulated genes by QCT. Knockdown of ATF3 could significantly increase the levels of SLC7A11, GPX4 and increased the cell viability. In addition, ferroptotic cells were found to be extremely pro-inflammatory by recruiting macrophages through CCL2, while QCT inhibited the chemotaxis of macrophages induced by ferroptosis in AKI.

Conclusions: Collectively, these results identify QCT as a ferroptosis inhibitor and provide new therapeutic strategies for diseases related to ferroptosis.
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http://dx.doi.org/10.1016/j.jare.2020.07.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7753233PMC
February 2021

Light depolarization based on dispersion degree of polarization.

Appl Opt 2020 Dec;59(36):11301-11309

The dispersion degree of polarization, a new definition of the depolarization degree of partially polarized beams, is first proposed, to the best of our knowledge, to measure the performance of fiber depolarizers. First, the description of the polarization based on the Poincaré sphere is introduced. Then, the modified Delaunay triangulation algorithm is introduced, and the calculation formula of the dispersion degree of polarization is given based on this algorithm. The experimental device was set up, and the dispersion degree of polarization of the depolarized light after the fiber depolarizer was measured to be 47.3%. The components and proportions of polarization in the depolarized light were also obtained. Compared with the degree of polarization, the dispersion degree of polarization can quantitatively analyze the light polarization evaluation in the time dimension and provide a numerical reference for improving the depolarizer, thus increasing the fiber sensor's accuracy.
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http://dx.doi.org/10.1364/AO.410293DOI Listing
December 2020

Contamination, source and potential risks of pharmaceuticals and personal products (PPCPs) in Baiyangdian Basin, an intensive human intervention area, China.

Sci Total Environ 2021 Mar 14;760:144080. Epub 2020 Dec 14.

State Key Laboratory of Urban and Regional Ecology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China.

The presence of pharmaceuticals and personal care products (PPCPs) has become a global concern, as it poses a threat to the environment, especially to the aquatic ecosystem. This study focused on 30 PPCPs found in the Baiyangdian basin of the Xiong'an New Area, in the core of Beijing-Tianjin-Hebei region, with intensive human interventions during two seasons. In general, 30 PPCPs were all frequently detected, ranging from 42.3 to 7710 ng/L in May and 48.9 to 1300 ng/L in November. Sulfamethoxazole, ofloxacin, anhydro-erythromycin, carbamazepine, caffeine, and were screened as the predominant PPCPs. The rivers input was an essential source of PPCPs. The source apportionment with a series of analytical methods revealed that domestic sewage was the primary source, and untreated water also crucial for PPCPs contamination. The risk assessment suggested carbamazepine, caffeine, ofloxacin, and anhydro-erythromycin exhibited relatively high ecological risks for protecting most species such as algae, fish, and flowers in the aquatic ecosystem, especially near the outlet of WWTPs. Thus, management strategies for such PPCPs will be needed. Intensive human interventions, including a prohibition of fish breeding, water diversion project, and wastewater treatment in villages, were having an effective role in alleviating PPCPs contamination.
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http://dx.doi.org/10.1016/j.scitotenv.2020.144080DOI Listing
March 2021

Perfluoroalkyl acids in rapidly developing coastal areas of China and South Korea: Spatiotemporal variation and source apportionment.

Sci Total Environ 2021 Mar 4;761:143297. Epub 2020 Nov 4.

School of Earth and Environmental Sciences & Research Institute of Oceanography, Seoul National University, Seoul 08826, Republic of Korea.

Polyfluoroalkyl substances (PFASs) are recognized as emerging contaminants that have captured worldwide attention. They are primarily transported in environments and spread around the globe due to their persistent and bioaccumulative characteristics. In this study, 15 PFASs were detected in major rivers of the rapidly developing coastal areas of China and South Korea. The concentrations and compositions of these PFASs varied greatly between different regions along the coastline. The total concentrations ranged from 14.9 to 16,500 ng L, and the mean concentrations of ΣPFASs in Liaodong Bay, Bohai Bay, Laizhou Bay, and the west coast of South Korea were 124 ng L, 81.4 ng L, 1550 ng L, and 36.2 ng L, respectively. In Laizhou Bay, the relatively high perfluorooctanoic acid (PFOA) was due to the high usage and manufacturing of PFOA-containing products and contributed 59% of the total compounds. In Liaodong Bay and Bohai Bay, PFBA and PFOA were the most abundant compounds, accounting for >55% of the total compounds. Along the west coast of South Korea, PFBA and PFPeA were the most prevalent compounds, contributing 28% and 24% of the total compounds, respectively. The data collected in the last decade were analyzed to investigate the temporal trends of selected PFASs. The total concentration of Σ PFASs decreased in both China and South Korea, while the proportion of short-chain PFASs increased. The proportion of C-C PFCAs in South Korea rapidly increased from 46% to 79% but decreased from 49% to 43% in China. The positive matrix factorization (PMF) model successfully addressed the site-specific source apportionment, which showed that 53% of the PFASs in Laizhou Bay were due to fluorine manufacturing. The results of this study provide novel insights into elucidating the spatiotemporal distribution and complicated sources of PFASs over a large area and provide a clear message for all stakeholders, water and coastal managers, and scientists.
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http://dx.doi.org/10.1016/j.scitotenv.2020.143297DOI Listing
March 2021

Risk assessment of potentially toxic elements accumulated in fish to Indo-Pacific humpback dolphins in the South China Sea.

Sci Total Environ 2021 Mar 3;761:143256. Epub 2020 Nov 3.

Provincial Key Laboratory of Marine Biotechnology, Institute of Marine Science, Shantou University, Shantou, Guangdong 515063, China; Southern Marine Science and Engineering Guangdong Laboratory, Guangzhou 511458, China. Electronic address:

Indo-Pacific humpback dolphins (Sousa chinensis) reside in shallow coastal waters where they are exposed to potentially toxic elements (PTEs) through dietary intake. We quantitatively assessed the risk posed by eight PTEs to the health of S. chinensis by determining their concentration in 13 fish species. The fish species represented the primary prey of S. chinensis in the South China Sea. Zn and Mn were the most dominant elements in fish at all sampling locations with concentrations ranges of 19.93-67.63 mg kg dry weight (dw) and 1.52-68.2 mg kg dw, respectively. The highest Zn concentration in fish was found in Coilia mystus (72.65 mg kg dw) followed by Liza carinatus (62.57 mg kg dw). At Jiangmen, Zn concentration was significantly lower in benthopelagic fish than in pelagic fish (p < 0.05, one-way ANOVA), while no significant difference was observed in other metals. The health risk posed by dietary intake assessed using the toxicity reference value showed that PTEs did not significant health risk to S. chinensis. In contrast, the risk quotient (RQ) based on reference doses ranged from 2.17 to 54.63 in prey fish that were contaminated with Zn and Cr indicating a potential health risk to S. chinensis in the South China Sea. The number of PTEs that posed a health risk varied between sites with seven out of eight PTEs above threshold at Jiangmen and six out of eight at Zhanjiang and Qinzhou. This study showed fish niche and location may influence the health risk posed by consumption of PTE-contaminated fish.
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http://dx.doi.org/10.1016/j.scitotenv.2020.143256DOI Listing
March 2021

Facile synthesis and antibacterial activity of geraniol conjugated chitosan oligosaccharide derivatives.

Carbohydr Polym 2021 Jan 16;251:117099. Epub 2020 Sep 16.

State Key Laboratory of Food Science and Technology, Jiangnan University, Lihu Road 1800, Wuxi 214122, PR China; School of Food Science and Technology, Jiangnan University, Lihu Road 1800, Wuxi 214122, PR China; International Joint Laboratory on Food Safety, Jiangnan University, Lihu Road 1800, Wuxi 214122, PR China; Collaborative Innovation Center of Food Safety and Quality Control, Jiangnan University, Lihu Road 1800, Wuxi 214122, PR China.

A new chitosan oligosaccharide derivative (COS-N-Ger), based on geraniol (Ger) modificated onto the NH position of chitosan oligosaccharide (COS) via a facile method, was prepared and employed to evaluate in vitro antibacterial activity. The structures of COS-N-Ger derivatives were confirmed by FT-IR, H, C NMR, and elemental analysis. The characterization results showed successful synthesis of derivatives and the degrees of substitution (DS) of COS-N-Ger1-3 were from 0.260 to 0.283 with the yields up to 78 %. The in vitro antibacterial activity evaluation results presented a significant inhibition effect of COS-N-Ger1-3 derivatives on Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) as compared to COS. Moreover, their antibacterial activities were dose-dependent and more sensitive to S. aureus than E. coli. The results provide reliable theoretical supports for exploring the application of COS derivatives in the food industry as new potential antibacterial agents.
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http://dx.doi.org/10.1016/j.carbpol.2020.117099DOI Listing
January 2021

Andrographolide sensitizes human renal carcinoma cells to TRAIL‑induced apoptosis through upregulation of death receptor 4.

Oncol Rep 2020 Nov 18;44(5):1939-1948. Epub 2020 Aug 18.

Key Laboratory of Organ Regeneration and Transplantation of The Ministry of Education, Institute of Translational Medicine, Institute of Virology and AIDS Research, The First Hospital of Jilin University, Changchun, Jilin 130061, P.R. China.

Tumor necrosis factor‑related apoptosis‑inducing ligand (TRAIL) selectively induces apoptosis in cancer cells, with minimal toxicity to normal tissues. However, accumulating evidence suggests that certain cancer types are insensitive to TRAIL signaling. The aim of this study was to identify an effective combination regimen, which can overcome TRAIL resistance in renal cancer cell. Herein, we found that human renal carcinoma cells (RCCs) are widely resistant to TRAIL‑mediated growth inhibition and subsequently identified that andrographolide (Andro), a major constituent of Andrographis paniculate, an annual herbaceous plant in the family Acanthaceae, counteracts TRAIL resistance in RCCs. Combined treatment with TRAIL and Andro suppressed cell viability as determined by MTS and proliferation as determined by EdU in a dose‑dependent manner and inactivated the clonogenic and migration ability of RCCs. Andro significantly enhances TRAIL‑mediated cell cycle arrest at the G2/M phase as determined by flow cytometry and senescence. Moreover, Andro restored TRAIL signaling, which in turns activated pro‑apoptosis caspases as determined by immunoblot assay. The TRAIL receptor, death receptor (DR)4, but not DR5, was found to be significantly upregulated in Andro‑treated RCC cells, which contributed to the role of Andro as a TRAIL sensitizer. The present study demonstrated that the combined treatment of Andro and TRAIL has potential therapeutic value against renal cancer.
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http://dx.doi.org/10.3892/or.2020.7737DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7551412PMC
November 2020

Ferroptosis involves in renal tubular cell death in diabetic nephropathy.

Eur J Pharmacol 2020 Dec 22;888:173574. Epub 2020 Sep 22.

School of Sciences, China Pharmaceutical University, Nanjing, 211198, China. Electronic address:

Ferroptosis is a novel type of programmed cell death characterized by iron-dependent accumulation of lipid hydroperoxides to lethal levels. Accumulative studies have indicated diabetic nephropathy (DN) as an inflammatory disorder, which involved immune modulation both in the occurrence and progression of the disease. In addition, DN is also considered as the major threatening complication of Diabetes mellitus (DM). However, other forms of programmed cell death, such as autophagy, apoptosis and necrosis, have been reported to be associated with DN, while there are no effective drugs to alleviate the damage of DN. In this study, we explored whether ferroptosis was involved in the progression of DN both in vivo and in vitro. We first established DN models using streptozotocin (STZ) and db/db mice. Results showed significant changes of ferroptosis associated markers, like increased expression levels of acyl-CoA synthetase long-chain family member 4 (ACSL4) and decreased expression levels of glutathione peroxidase 4 (GPX4) in DN mice. Also lipid peroxidation products and iron content were increased in DN mice. Next, in vitro, ferroptosis inducer erastin or RSL3 could induce renal tubular cell death, while iron and high ACSL4 levels sensitised ferroptosis. Finally, ACSL4 inhibitor rosiglitazone (Rosi) was used in the development of DN, which improved survival rate and kidney function, reduced lipid peroxidation product MDA and iron content. In summary, we first found ferroptosis was involved in DN and ferroptosis might be as a future direction in the treatment of DN.
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http://dx.doi.org/10.1016/j.ejphar.2020.173574DOI Listing
December 2020

Consistent apparent Young's modulus of human embryonic stem cells and derived cell types stabilized by substrate stiffness regulation promotes lineage specificity maintenance.

Cell Regen 2020 Sep 3;9(1):15. Epub 2020 Sep 3.

Department of Biomedical Engineering, Tsinghua-Peking Center for Life Sciences, MOE Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology, School of Medicine, Tsinghua University, Beijing, 100084, China.

Background: Apparent Young's modulus (AYM), which reflects the fundamental mechanical property of live cells measured by atomic force microscopy and is determined by substrate stiffness regulated cytoskeletal organization, has been investigated as potential indicators of cell fate in specific cell types. However, applying biophysical cues, such as modulating the substrate stiffness, to regulate AYM and thereby reflect and/or control stem cell lineage specificity for downstream applications, remains a primary challenge during in vitro stem cell expansion. Moreover, substrate stiffness could modulate cell heterogeneity in the single-cell stage and contribute to cell fate regulation, yet the indicative link between AYM and cell fate determination during in vitro dynamic cell expansion (from single-cell stage to multi-cell stage) has not been established.

Results: Here, we show that the AYM of cells changed dynamically during passaging and proliferation on substrates with different stiffness. Moreover, the same change in substrate stiffness caused different patterns of AYM change in epithelial and mesenchymal cell types. Embryonic stem cells and their derived progenitor cells exhibited distinguishing AYM changes in response to different substrate stiffness that had significant effects on their maintenance of pluripotency and/or lineage-specific characteristics. On substrates that were too rigid or too soft, fluctuations in AYM occurred during cell passaging and proliferation that led to a loss in lineage specificity. On a substrate with 'optimal' stiffness (i.e., 3.5 kPa), the AYM was maintained at a constant level that was consistent with the parental cells during passaging and proliferation and led to preservation of lineage specificity. The effects of substrate stiffness on AYM and downstream cell fate were correlated with intracellular cytoskeletal organization and nuclear/cytoplasmic localization of YAP.

Conclusions: In summary, this study suggests that optimal substrate stiffness regulated consistent AYM during passaging and proliferation reflects and contributes to hESCs and their derived progenitor cells lineage specificity maintenance, through the underlying mechanistic pathways of stiffness-induced cytoskeletal organization and the downstream YAP signaling. These findings highlighted the potential of AYM as an indicator to select suitable substrate stiffness for stem cell specificity maintenance during in vitro expansion for regenerative applications.
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http://dx.doi.org/10.1186/s13619-020-00054-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7467757PMC
September 2020

Acidic deep eutectic solvent assisted isolation of lignin containing nanocellulose from thermomechanical pulp.

Carbohydr Polym 2020 Nov 6;247:116727. Epub 2020 Jul 6.

Sustainable Functional Biomaterials Laboratory, Department of Wood Science, The University of British Columbia, Vancouver, BC, V6T 1Z4, Canada. Electronic address:

Nanocellulose is a promising material but its isolation generally requires unrecyclable hazardous chemicals and high energy consumption and its overall yield is low due to the use of high purity cellulose as precursor. In order to overcome these shortcomings, in this study, thermomechanical pulp (TMP) was investigated as a precursor for isolating lignin containing nanocellulose (LNC) using an environmentally friendly acidic deep eutectic solvent (DES) pre-treatment. Flat "ribbon" like LNCs (around 7.1 nm wide, 3.7 nm thick) with uniformly distributed lignin nanoparticles of 20-50 nm in diameter were successfully obtained at 57 % yield under optimum pre-treatment conditions (90 °C, 6 h, 1:1 oxalic acid dihydrate to choline chloride ratio). The LNCs exhibit cellulose Iβ structure, high lignin content (32.6 %), and high thermal stability (T of 358 °C). In general, green acidic DES pre-treatment has shown high efficiency in converting high lignin content biomass into value-added LNC, which benefits both lignocellulose utilization and environmental protection.
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http://dx.doi.org/10.1016/j.carbpol.2020.116727DOI Listing
November 2020

Control of translation during the unfolded protein response in maize seedlings: Life without PERKs.

Plant Direct 2020 Jul 30;4(7):e00241. Epub 2020 Jul 30.

Interdepartmental Genetics and Genomics Major Iowa State University Ames IA USA.

The accumulation of misfolded proteins in the endoplasmic reticulum (ER) defines a condition called ER stress that induces the unfolded protein response (UPR). The UPR in mammalian cells attenuates protein synthesis initiation, which prevents the piling up of misfolded proteins in the ER. Mammalian cells rely on Protein Kinase RNA-Like Endoplasmic Reticulum Kinase (PERK) phosphorylation of eIF2α to arrest protein synthesis, however, plants do not have a PERK homolog, so the question is whether plants control translation in response to ER stress. We compared changes in RNA levels in the transcriptome to the RNA levels protected by ribosomes and found a decline in translation efficiency, including many UPR genes, in response to ER stress. The decline in translation efficiency is due to the fact that many mRNAs are not loaded onto polyribosomes (polysomes) in proportion to their increase in total RNA, instead some of the transcripts accumulate in stress granules (SGs). The RNAs that populate SGs are not derived from the disassembly of polysomes because protein synthesis remains steady during stress. Thus, the surge in transcription of UPR genes in response to ER stress is accompanied by the formation of SGs, and the sequestration of mRNAs in SGs may serve to temporarily relieve the translation load during ER stress.
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http://dx.doi.org/10.1002/pld3.241DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7390965PMC
July 2020

Digestive solubilization of Cd in highly-contaminated sediment by marine deposit feeders: The roles of intestinal surfactants in Cd mobilization and Re-Adsorption processes.

Environ Pollut 2020 Nov 2;266(Pt 3):115149. Epub 2020 Jul 2.

Key Laboratory of Pollution Ecology and Environmental Engineering, Institute of Applied Ecology, Chinese Academy of Sciences, Shenyang, 110016, China.

Marine deposit feeders are of ecological significance in transferring sedimentary Cd along aquatic food chains. A key process for this transfer is these organisms' dietary uptake of Cd via solubilization of Cd present in ingested contaminated sediment. To better understand the bioavailability of sedimentary Cd to deposit feeders, the present study used in vitro extraction experiments to explore the contribution of different digestive agents (proteins, amino acids and surfactants) to the solubilization of Cd from sediment collected in a highly-contaminated Chinese bay. This was done for various commercially-available mimetic digestive agents (the protein BSA, a mixture of amino acids, and the surfactants rhamnolipid and SDS), and for proteins and surfactants collected from the gut juice of a sipunculan worm. The Cd mobilization capacity of BSA was significantly higher than that of the amino acids and the commercial surfactants. In the presence of BSA, > 70% of the released Cd became associated with this protein. In contrast, the digestive proteins from the sipunculan had a lower Cd mobilization capacity than was the case for the other digestive agents and the majority of the released Cd (∼80%) was associated with small molecular weight fractions. The differences in Cd mobilization between the BSA and the digestive proteins were attributed to differences in their sediment-adsorption tendencies and their Cd-complexing capacities. While the digestive surfactants had minor effects on the release of sedimentary Cd, they significantly enhanced Cd mobilization by the digestive proteins when both were present simultaneously. Our results suggest that the characteristics of proteins should be considered when using commercially-available mimetic digestive agents to explore Cd bioavailability in sediments. Furthermore, digestive surfactants seem to have important effects on the solubilization of Cd during gut passage by reducing the adsorption of the digestive proteins to the sediments.
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http://dx.doi.org/10.1016/j.envpol.2020.115149DOI Listing
November 2020

Experimental investigation of far-field human cough airflows from healthy and influenza-infected subjects.

Indoor Air 2020 Sep 4;30(5):966-977. Epub 2020 May 4.

Department of Mechanical and Materials Engineering, University of Western Ontario, London, ON, Canada.

Seasonal influenza epidemics have been responsible for causing increased economic expenditures and many deaths worldwide. Evidence exists to support the claim that the virus can be spread through the air, but the relative significance of airborne transmission has not been well defined. Particle image velocimetry (PIV) and hot-wire anemometry (HWA) measurements were conducted at 1 m away from the mouth of human subjects to develop a model for cough flow behavior at greater distances from the mouth than were studied previously. Biological aerosol sampling was conducted to assess the risk of exposure to airborne viruses. Throughout the investigation, 77 experiments were conducted from 58 different subjects. From these subjects, 21 presented with influenza-like illness. Of these, 12 subjects had laboratory-confirmed respiratory infections. A model was developed for the cough centerline velocity magnitude time history. The experimental results were also used to validate computational fluid dynamics (CFD) models. The peak velocity observed at the cough jet center, averaged across all trials, was 1.2 m/s, and an average jet spread angle of θ = 24° was measured, similar to that of a steady free jet. No differences were observed in the velocity or turbulence characteristics between coughs from sick, convalescent, or healthy participants.
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http://dx.doi.org/10.1111/ina.12680DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7264733PMC
September 2020

Restless legs syndrome following the use of ziprasidone: a case report.

Gen Psychiatr 2020 11;33(2):e100112. Epub 2020 Mar 11.

Department of Psychiatry, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Restless legs syndrome (RLS) is a common sleep-related movement disorder characterised by an uncomfortable urge to move the legs that occurs during periods of inactivity. Although there have been many case reports on antipsychotic-induced RLS, ziprasidone has never been reported as a cause of RLS. We present a case of a female patient with schizophrenia who presented with symptoms of RLS following the administration of high doses of ziprasidone added to quetiapine and valproate. The patient's symptoms of RLS occurred following the administration and titration of ziprasidone to 160 mg, and were relieved upon reducing the dose to 120 mg/day. Other potential causative medications and differential diagnoses that could have caused similar symptoms were excluded. Clinicians should be aware of the potential for ziprasidone-induced RLS. Dopamine and serotonin interaction could be the mechanism underlying ziprasidone-induced RLS.
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http://dx.doi.org/10.1136/gpsych-2019-100112DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7066599PMC
March 2020

Detoxification and reclamation of hydrometallurgical arsenic- and trace metals-bearing gypsum via hydrothermal recrystallization in acid solution.

Chemosphere 2020 Jul 24;250:126290. Epub 2020 Feb 24.

Key Laboratory of Pollution Ecology and Environmental Engineering, Institute of Applied Ecology, Chinese Academy of Sciences, Shenyang 110016, China. Electronic address:

Arsenic- and trace metals-bearing gypsum (As-gypsum) is one of the major hazardous solid wastes produced from metallurgical industry that poses a serious threat to the environment. However, the method for effective extraction of As and trace metals from As-gypsum is still lacking. In this study, simultaneous extraction of As and trace metals from a hydrometallurgical As-gypsum via hydrothermal recrystallization in acid solution was investigated. The effects of the type (HSO vs HCl) and concentration of acid, and temperature on extraction efficiency were assessed. The results showed that 99% As, >92% Cu and >96% Zn could be extracted from the As-gypsum during hydrothermal treatment in 6 mol L HSO at 90 and 120 °C, but Pb and Cd could not be extracted efficiently. The results of hydrothermal treatment in HCl solutions demonstrated that higher HCl concentration and temperature significantly enhanced the extraction efficiency and 100% As, Cu, Zn, Pb and >90% Cd were removed from the As-gypsum after treatment in 6 mol L HCl, at 120 °C, for 12 h. X-ray diffraction (XRD), scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), and Raman spectroscopy results revealed that dissolution-recrystallization of gypsum is the key process for the removal of the incorporated As and trace metals. Thermodynamic modelling indicated that the released HAsO/Me transformed into HAsO/MeCl (1 ≤ n ≤ 4) species in HCl solution, hence inhibiting their reincorporation into the recrystallization products via isomorphic substitution for SO/Ca. This work provides a simple and effective method for detoxification and reclamation of As-gypsum.
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http://dx.doi.org/10.1016/j.chemosphere.2020.126290DOI Listing
July 2020

Observation of a thermoelectric Hall plateau in the extreme quantum limit.

Nat Commun 2020 Feb 25;11(1):1046. Epub 2020 Feb 25.

Department of Physics, Southern University of Science and Technology, 518055, Shenzhen, China.

The thermoelectric Hall effect is the generation of a transverse heat current upon applying an electric field in the presence of a magnetic field. Here, we demonstrate that the thermoelectric Hall conductivity α in the three-dimensional Dirac semimetal ZrTe acquires a robust plateau in the extreme quantum limit of magnetic field. The plateau value is independent of the field strength, disorder strength, carrier concentration, or carrier sign. We explain this plateau theoretically and show that it is a unique signature of three-dimensional Dirac or Weyl electrons in the extreme quantum limit. We further find that other thermoelectric coefficients, such as the thermopower and Nernst coefficient, are greatly enhanced over their zero-field values even at relatively low fields.
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http://dx.doi.org/10.1038/s41467-020-14819-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7042294PMC
February 2020

Influence Mechanism of Cu Layer Thickness on Photoelectric Properties of IWO/Cu/IWO Films.

Materials (Basel) 2019 Dec 25;13(1). Epub 2019 Dec 25.

State Key Laboratory of Integrated Optoelectronics, College of Electronic Science and Engineering, Jilin University, 2699 Qianjin Street, Changchun 130012, China.

Transparent conductive IWO/Cu/IWO (W-doped InO) films were deposited on quartz substrates by magnetron sputtering of IWO and Cu in the Ar atmosphere. The X-ray diffraction (XRD) patterns identified the cubic iron-manganese ore crystal structure of the IWO layers. The influence of the thickness of the intermediate ultra-thin Cu layers on the optical and electrical properties of the multilayer films was analyzed. As the Cu layer thickness increases from 4 to 10 nm, the multilayer resistivity gradually decreases to 4.5 × 10 Ω·cm, and the optical transmittance in the mid-infrared range increases first and then decreases with a maximum of 72%, which serves as an excellent candidate for the mid-infrared transparent electrode.
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http://dx.doi.org/10.3390/ma13010113DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6982096PMC
December 2019

Adjustable flexure mount to compensate for deformation of an optic surface.

Appl Opt 2019 Dec;58(34):9370-9375

An adjustable mounting structure is proposed to compensate for surface deformation of a mirror caused by the assembly process. The mount adopts a six-point support based on the kinematic mount principle. Three of the support points are adjustable, and they are moved along the axial direction by actuators. Surface deformation is expressed by Zernike coefficients in this paper, and a sensitivity matrix of the surface deformation is established by varying the unit displacement of each adjustment support point and getting the corresponding Zernike coefficient changes. The surface deformation is measured, and the compensation adjustment of each adjustable support point is then obtained by anti-sensitivity calculation. Finally, the feasibility of present support structure design and surface figure compensating method are verified by experiments. The experimental results show that the present structure and method could significantly reduce the surface deformation caused by the assembly process. The surface deformation is 4.6 nm RMS after assembly and it is decreased to 1.3 nm RMS after four iterations of compensation, which is close to the 1.1 nm RMS after optical polishing.
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http://dx.doi.org/10.1364/AO.58.009370DOI Listing
December 2019

Effects of pre-ozonation on the cell characteristics and N-nitrosodimethylamine formation at three growth phases of Microcystis aeruginosa.

Environ Sci Pollut Res Int 2020 Jan 9;27(1):873-881. Epub 2019 Dec 9.

Xiamen Engineering & Technology Research Center for Urban Water Environment Planning and Remediation, College of Civil Engineering, Huaqiao University, Xiamen, 361021, Fujian, People's Republic of China.

Pre-oxidation in water treatment is considered an effective method to enhance the removal of algal cells and their exuded organic matters. However, pre-oxidation also alters the characteristics of algae and consequently influences disinfection processes. The existing studies mainly focused on the stationary growth phase, but little is known for the exponential and declined phases. The objectives of this study were to examine the effects of pre-ozonation on the integrity of algal cells, the release of algal organic matters, and the formation of disinfection by-products like N-nitrosodimethylamine (NDMA) from Microcystis aeruginosa (M. aeruginosa) at three growth phases. The results demonstrated that pre-ozonation was efficient to inactivate M. aeruginosa cells. The severity of M. aeruginosa cell damage increased as the ozone dosage increased from 0.5 to 2.0 mg/L. The damage of cell membranes resulted in the release of intracellular organic matters. Excitation-emission matrix spectra (EEMS) analysis indicated that ozone mainly reacted with soluble microbial products (SMP). With the increase of ozone concentration, although the trend of NDMA formation was similar for all three growth phases, more production of NDMA by algal cells was observed at the declined phase. In the post-disinfection process, chloramine showed the potential as a more suitable disinfectant than chlorination after pre-ozonation to minimize the NDMA formation. Therefore, appropriate pre-ozonation is beneficial to reduce the NDMA formation from exponential algae, while has no significant change during both stationary and declined phases.
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http://dx.doi.org/10.1007/s11356-019-06677-8DOI Listing
January 2020

Quantitative Proteome Landscape of the NCI-60 Cancer Cell Lines.

iScience 2019 Nov 31;21:664-680. Epub 2019 Oct 31.

Department of Biology, Institute of Molecular Systems Biology, ETH Zurich, Zurich, Switzerland; Faculty of Science, University of Zurich, Zurich, Switzerland. Electronic address:

Here we describe a proteomic data resource for the NCI-60 cell lines generated by pressure cycling technology and SWATH mass spectrometry. We developed the DIA-expert software to curate and visualize the SWATH data, leading to reproducible detection of over 3,100 SwissProt proteotypic proteins and systematic quantification of pathway activities. Stoichiometric relationships of interacting proteins for DNA replication, repair, the chromatin remodeling NuRD complex, β-catenin, RNA metabolism, and prefoldins are more evident than that at the mRNA level. The data are available in CellMiner (discover.nci.nih.gov/cellminercdb and discover.nci.nih.gov/cellminer), allowing casual users to test hypotheses and perform integrative, cross-database analyses of multi-omic drug response correlations for over 20,000 drugs. We demonstrate the value of proteome data in predicting drug response for over 240 clinically relevant chemotherapeutic and targeted therapies. In summary, we present a novel proteome resource for the NCI-60, together with relevant software tools, and demonstrate the benefit of proteome analyses.
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http://dx.doi.org/10.1016/j.isci.2019.10.059DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6889472PMC
November 2019

Molecular signatures of retinal ganglion cells revealed through single cell profiling.

Sci Rep 2019 10 31;9(1):15778. Epub 2019 Oct 31.

Emmune, Inc, 14155 U.S Highway 1, Juno Beach, FL, 33408, USA.

Retinal ganglion cells can be classified into more than 40 distinct subtypes, whether by functional classification or transcriptomics. The examination of these subtypes in relation to their physiology, projection patterns, and circuitry would be greatly facilitated through the identification of specific molecular identifiers for the generation of transgenic mice. Advances in single cell transcriptomic profiling have enabled the identification of molecular signatures for cellular subtypes that are only rarely found. Therefore, we used single cell profiling combined with hierarchical clustering and correlate analyses to identify genes expressed in distinct populations of Parvalbumin-expressing cells and functionally classified RGCs. RGCs were manually isolated based either upon fluorescence or physiological distinction through cell-attached recordings. Microarray hybridization and RNA-Sequencing were employed for the characterization of transcriptomes and in situ hybridization was utilized to further characterize gene candidate expression. Gene candidates were identified based upon cluster correlation, as well as expression specificity within physiologically distinct classes of RGCs. Further, we identified Prph, Ctxn3, and Prkcq as potential candidates for ipRGC classification in the murine retina. The use of these genes, or one of the other newly identified subset markers, for the generation of a transgenic mouse would enable future studies of RGC-subtype specific function, wiring, and projection.
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http://dx.doi.org/10.1038/s41598-019-52215-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6823391PMC
October 2019

A second open reading frame in human enterovirus determines viral replication in intestinal epithelial cells.

Nat Commun 2019 09 6;10(1):4066. Epub 2019 Sep 6.

Key Laboratory of Organ Regeneration and Transplantation of Ministry of Education, Institute of Translational Medicine, First Hospital, Jilin University, Changchun, Jilin, 130021, China.

Human enteroviruses (HEVs) of the family Picornaviridae, which comprises non-enveloped RNA viruses, are ubiquitous worldwide. The majority of EV proteins are derived from viral polyproteins encoded by a single open reading frame (ORF). Here, we characterize a second ORF in HEVs that is crucial for viral intestinal infection. Disruption of ORF2p expression decreases the replication capacity of EV-A71 in human intestinal epithelial cells (IECs). Ectopic expression of ORF2p proteins derived from diverse enteric enteroviruses sensitizes intestinal cells to the replication of ORF2p-defective EV-A71 and respiratory enterovirus EV-D68. We show that the highly conserved WIGHPV domain of ORF2p is important for ORF2p-dependent viral intestinal infection. ORF2p expression is required for EV-A71 particle release from IECs and can support productive EV-D68 infection in IECs by facilitating virus release. Our results indicate that ORF2p is a determining factor for enteric enterovirus replication in IECs.
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http://dx.doi.org/10.1038/s41467-019-12040-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6731315PMC
September 2019

A Surveillance, Epidemiology and End Results database analysis of the prognostic value of organ-specific metastases in patients with advanced prostatic adenocarcinoma.

Oncol Lett 2019 Aug 7;18(2):1057-1070. Epub 2019 Jun 7.

Department of Urology, The First Hospital of Jilin University, Changchun, Jilin 130012, P.R. China.

Prostate cancer (PCa) survival markedly decreases with the occurrence of distant metastasis, and treatment decisions can be influenced by metastasis site, and affect patient survival outcomes. The aim of the present study was to evaluate the potential prognostic value of metastasis to specific sites and the prognostic value of prostatectomy in patients with only bone metastasis, and to determine potential risk factors for bone metastasis in prostatic adenocarcinoma using large scale clinical data. The Surveillance, Epidemiology and End Results (SEER) database (2010-2013) was queried via the SEER*Stat (version 8.3.4) program. A total of 210,730 prostatic adenocarcinoma patients were identified from the SEER database between January 2010 and December 2013. Univariate and multivariate Cox regression analysis and Kaplan-Meier curves were used for survival comparisons with corresponding 95% confidence intervals. Patients with PCa with only liver metastatic lesions had worse overall and cancer-specific survival rates compared with those patients with only bone or lung metastasis. Multivariate Cox regression analysis revealed that age <50 years, married status, T1 and T3 tumor stage according to Tumor-Node-Metastasis (TNM) staging system from the 7th AJCC cancer staging manual, and prostatectomy were associated with better overall survival and cancer-specific survival in patients with only bone metastasis. Binary logistic regression analysis revealed that unmarried status, African descent and undifferentiated histological grade were risk factors for PCa bone metastasis. Prostatic adenocarcinoma patients with only liver metastasis had worse prognostic outcomes compared with patients with other distant organ metastases. Prostatectomy improved the 3-year survival rate in stage IV PCa patients and stage IV PCa patients with only bone metastasis. These findings were based on large-scale clinical data and can provide novel perspectives for the treatment of patients with advanced prostate adenocarcinoma.
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http://dx.doi.org/10.3892/ol.2019.10461DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6607368PMC
August 2019

Catalpol alleviates adriamycin-induced nephropathy by activating the SIRT1 signalling pathway in vivo and in vitro.

Br J Pharmacol 2019 12 11;176(23):4558-4573. Epub 2019 Dec 11.

Department of Clinical Pharmacology, College of Pharmacy, Dalian Medical University, Dalian, Liaoning, China.

Background And Purpose: Catalpol, a water-soluble active ingredient isolated from Rehmannia glutinosa, exhibits multiple pharmacological activities. However, the mechanism(s) underlying protection against renal injury by catalpol remains unknown.

Experimental Approach: Adriamycin-induced kidney injury models associated with podocyte damage were employed to investigate the nephroprotective effects of catalpol. In vivo, TUNEL and haematoxylin-eosin staining was used to evaluate the effect of catalpol on kidney injury in mice. In vitro, effects of catalpol on podocyte damage induced by adriamycin was determined by elisa kit, flow cytometry, Hoechst 33342, and TUNEL staining. The mechanism was investigated by siRNA, EX527, and docking simulations.

Key Results: In vivo, catalpol treatment significantly improved adriamycin-induced kidney pathological changes and decreased the number of apoptotic cells. In vitro, catalpol markedly decreased the intracellular accumulation of adriamycin and reduced the calcium ion level in podocytes and then attenuated apoptosis. Importantly, the regulatory effects of catalpol on sirtuin 1 (SIRT1), multidrug resistance-associated protein 2 (MRP2), and the TRPC6 channel were mostly abolished after incubation with SIRT1 siRNA or the SIRT1-specific inhibitor EX527. Furthermore, docking simulations showed that catalpol efficiently oriented itself in the active site of SIRT1, indicating a higher total binding affinity score than that of other SIRT1 activators, such as resveratrol, SRT2104, and quercetin.

Conclusion And Implications: Taken together, our results suggest that catalpol exhibits strong protective effects against adriamycin-induced nephropathy by inducing SIRT1-mediated inhibition of TRPC6 expression and enhancing MRP2 expression.
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http://dx.doi.org/10.1111/bph.14822DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6932948PMC
December 2019

Adenovirus oncoprotein E4orf6 triggers Cullin5 neddylation to activate the CLR5 E3 ligase for p53 degradation.

Biochem Biophys Res Commun 2019 09 10;516(4):1242-1247. Epub 2019 Jul 10.

Key Laboratory of Organ Regeneration and Transplantation of Ministry of Education, Institute of Translational Medicine, Institute of Virology and AIDS Research, The First Hospital of Jilin University, Changchun, Jilin Province, 130021, China. Electronic address:

The human adenovirus oncoprotein E4orf6 hijacks intracellular Cullin 5-based E3 ubiquitin ligases (CRL5s) to induce the degradation of host proteins, including p53, that impede efficient viral replication. The complex also relies on another viral protein, E1B55K, to recruit substrates for ubiquitination. However, the determinants of adenoviral E4orf6-CRL5 E3 ligase-mediated p53 degradation in the scaffolding protein Cullin5 remain rarely investigated. Here, we demonstrated that the viral protein E4orf6 triggered relocalization of the Cullin5 protein from the cytoplasm to the nucleus and induced activation of the CRL5 E3 ligase via facilitating neddylation. The expression of the deneddylase SENP8/Den1 was significantly downregulated by E4orf6. We then identified SENP8 as a natural restriction factor for E4orf6-induced p53 degradation. Furthermore, our results indicated that the NEDD8-conjugating E2 enzyme UBE2M was essential for E4orf6-mediated p53 degradation and that its dominant negative mutant UBE2M C111S dramatically blocked E4orf6 functions. The Nedd8-activating enzyme inhibitor MLN4924 decreased E4orf6-induced neddylation of the cullin5 protein and subsequently suppressed p53 degradation. Collectively, our findings illuminate the strategy by which this viral oncoprotein specifically utilizes the neddylation pathway to activate host CRL E3 ligases to degrade host restriction factors. Disrupting this post-translational modification is an attractive pharmacological intervention against human adenoviruses.
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http://dx.doi.org/10.1016/j.bbrc.2019.07.028DOI Listing
September 2019

Research on the Frequency-Dependent Halfwave Voltage of a Multifunction Integrated Optical Chip in an Interferometric Fiber Optic Gyroscope.

Sensors (Basel) 2019 Jun 27;19(13). Epub 2019 Jun 27.

State Key Laboratory of Modern Optical Instrumentation, Zhejiang University, No. 38 Zheda Road, Hangzhou 310027, China.

The multifunction integrated optical chip (MIOC) is one of the most critical parts of the interferometric fiber optic gyroscope (IFOG), and research on the halfwave voltage of the MIOC is meaningful for a high-precision IFOG. In this paper, the correlation between the frequency and halfwave voltage, which affects the interference light intensity of IFOG, is presented theoretically. A widespread measurement method for frequency dependence of the halfwave voltage, based on lock-in amplification and sinusoidal modulation, is proposed. Further, the measurement result and the oscillation of interference light intensity in the Sagnac interferometer are presented, which are in great agreement with the theory. This paper proposes the frequency dependence of the halfwave voltage and provides a new error research direction for the improvement of the MIOC in a high-precision IFOG.
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http://dx.doi.org/10.3390/s19132851DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6651879PMC
June 2019

Transcriptomic Analysis of Leaf Sheath Maturation in Maize.

Int J Mol Sci 2019 May 19;20(10). Epub 2019 May 19.

State Key Laboratory of Crop Biology, College of Agronomic Sciences, Shandong Agricultural University, Tai'an 271018, China.

The morphological development of the leaf greatly influences plant architecture and crop yields. The maize leaf is composed of a leaf blade, ligule and sheath. Although extensive transcriptional profiling of the tissues along the longitudinal axis of the developing maize leaf blade has been conducted, little is known about the transcriptional dynamics in sheath tissues, which play important roles in supporting the leaf blade. Using a comprehensive transcriptome dataset, we demonstrated that the leaf sheath transcriptome dynamically changes during maturation, with the construction of basic cellular structures at the earliest stages of sheath maturation with a transition to cell wall biosynthesis and modifications. The transcriptome again changes with photosynthesis and lignin biosynthesis at the last stage of sheath tissue maturation. The different tissues of the maize leaf are highly specialized in their biological functions and we identified 15 genes expressed at significantly higher levels in the leaf sheath compared with their expression in the leaf blade, including the homologs and , () and transcription factors from the B3 domain, C2H2 zinc finger and homeobox gene families, implicating these genes in sheath maturation and organ specialization.
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http://dx.doi.org/10.3390/ijms20102472DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6566692PMC
May 2019

Sirt2 epigenetically down-regulates PDGFRα expression and promotes CG4 cell differentiation.

Cell Cycle 2019 05 10;18(10):1095-1109. Epub 2019 May 10.

a Department of Biochemistry and Molecular Biology , Basic Medical School, Henan University , Kaifeng , China.

We have previously found that Sirt2 enhanced the outgrowth of cellular processes and MBP expression in CG4 cells, where Sirt2 expression is suppressed by transcription factor Nkx2.2. However, the detailed mechanism of Sirt2 facilitating oligodendroglial cell differentiation remained unclear. In the present study, we observed that Sirt2 partially translocated into the nuclei when CG4 cells were induced to differentiate. Sirt2 was detected at the CpG island of PDGFRα promoter via ChIP assay during the cells differentiation process rather than during the state of growth. Sirt2 deacetylated protein(s) bound to the promoter of PDGFRα and simultaneously appeared to facilitate histone3 K27 tri-methylation, both of which are suppressive signatures on gene transcription activation. In bisulfate assay, we identified that Sirt2 significantly induced DNA methylation of PDGFRα promoter compared with the control. Consistently, Sirt2 overexpression down-regulated PDGFRα expression in CG4 cells. The knock-down of PDGFRα or Sirt2 over-expression repressed cell proliferation, but knock-down of Sirt2 promoted cell proliferation. Taken together, Sirt2 translocated into the nuclei while the cells initiated a differentiation process, facilitating CG4 cell differentiation partially through epigenetic modification and suppression of PDGFRα expression. The repression of PDGFRα expression mediated by Sirt2 appeared to facilitate a transition of cellular processes, i.e. from a proliferating progenitor state to a post-mitotic state in CG4 cells.
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http://dx.doi.org/10.1080/15384101.2019.1609818DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6592232PMC
May 2019

Giving waterbodies the treatment they need: A critical review of the application of constructed floating wetlands.

J Environ Manage 2019 May 13;238:484-498. Epub 2019 Mar 13.

Marine Biology Institute, Shantou University, Daxue Road 243, Shantou City, 515063, PR China. Electronic address:

Water quality is declining worldwide and an increasing number of waterbodies lose their ecological function due to human population growth and climate change. Constructed floating wetlands (CFWs) are a promising ecological engineering tool for restoring waterbodies. The functionality of CFWs has been studied in-situ, in mesocosms and in the laboratory, but a systematic review of the success of in situ applications to improve ecosystem health is missing to date. This review summarises the pollutant dynamics in the presence of CFWs and quantifies removal efficiencies for major pollutants with a focus on in situ applications, including studies that have only been published in the Chinese scientific literature. We find that well designed CFWs successfully decrease pollutant concentrations and improve the health of the ecosystem, shown by lower algae biomass and more diverse fish, algae and invertebrate communities. However, simply extrapolating pollutant removal efficiencies from small-scale experiments will lead to overestimating the removal capacity of nitrogen, phosphorus and organic matter of in situ applications. We show that predicted climate change and eutrophication scenarios will likely increase the efficiency rate of CFWs, mainly due to increased growth and pollutant uptake rates at higher temperatures. However, an increase in rainfall intensity could lead to a lower efficiency of CFWs due to shorter hydraulic retention times and more pollutants being present in the particulate, not the dissolved form. Finally, we develop a framework that will assist water resource managers to design CFWs for specific management purposes. Our review clearly highlights the need of more detailed in situ studies, particularly in terms of understanding the short- and long-term ecosystem response to CFWs under different climate change scenarios.
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http://dx.doi.org/10.1016/j.jenvman.2019.02.064DOI Listing
May 2019