Ramzi Mohammad

Ramzi Mohammad

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Ramzi Mohammad

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DNA-Methylation-Caused Downregulation of Contributes to the High Expression of XPO1 and the Aggressive Growth of Tumors in Pancreatic Ductal Adenocarcinoma.

Cancers (Basel) 2019 Aug 2;11(8). Epub 2019 Aug 2.

Department of Oncology, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA.

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http://dx.doi.org/10.3390/cancers11081101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6721494PMC
August 2019

Pharmacotherapeutic strategies for treating pancreatic cancer: advances and challenges.

Expert Opin Pharmacother 2019 04 28;20(5):535-546. Epub 2018 Dec 28.

a Department of Oncology, Karmanos Cancer institute , Wayne State University , Detroit , MI , USA.

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https://www.tandfonline.com/doi/full/10.1080/14656566.2018.1
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http://dx.doi.org/10.1080/14656566.2018.1561869DOI Listing
April 2019

Obesity-induced MBD2_v2 expression promotes tumor-initiating triple-negative breast cancer stem cells.

Mol Oncol 2019 04 1;13(4):894-908. Epub 2019 Mar 1.

Department of Oncology, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI, USA.

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http://dx.doi.org/10.1002/1878-0261.12444DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6441886PMC
April 2019

Anticancer Activity of Camel Milk via Induction of Autophagic Death in Human Colorectal and Breast Cancer Cells

Asian Pac J Cancer Prev 2018 Dec 25;19(12):3501-3509. Epub 2018 Dec 25.

Translational Research Institute, Academic Health System, Hamad Medical Corporation, Doha, State of Qatar. Email:

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http://dx.doi.org/10.31557/APJCP.2018.19.12.3501DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6428541PMC
December 2018

Dysregulated expression of SKP2 and its role in hematological malignancies.

Leuk Lymphoma 2018 05 10;59(5):1051-1063. Epub 2017 Aug 10.

a Translational Research Institute, Academic Health System , Hamad Medical Corporation , Doha , Qatar.

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http://dx.doi.org/10.1080/10428194.2017.1359740DOI Listing
May 2018

Nuclear Export Inhibition for Pancreatic Cancer Therapy.

Cancers (Basel) 2018 May 7;10(5). Epub 2018 May 7.

Department of Oncology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA.

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http://dx.doi.org/10.3390/cancers10050138DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5977111PMC
May 2018

Vascular Endothelial Growth Factor (VEGF) Signaling in Tumour Vascularization: Potential and Challenges.

Curr Vasc Pharmacol 2017 ;15(4):339-351

Translational Research Institute, Academic Health System, Hamad Medical Corporation, PO Box 3050, Doha. Qatar.

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http://dx.doi.org/10.2174/1570161115666170105124038DOI Listing
April 2018

The Replacement of five Consecutive Amino Acids in the Cyt1A Protein of Bacillus thuringiensis Enhances its Cytotoxic Activity against Lung Epithelial Cancer Cells.

Toxins (Basel) 2018 03 16;10(3). Epub 2018 Mar 16.

Biological & Environmental Sciences Department, College of Arts and Sciences, Qatar University, P.O. Box 2713 Doha, Qatar.

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http://dx.doi.org/10.3390/toxins10030125DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5869413PMC
March 2018

Cholesterol Depletion Alters Cardiomyocyte Subcellular Signaling and Increases Contractility.

PLoS One 2016 21;11(7):e0154151. Epub 2016 Jul 21.

Department of Physiology, Wayne State University School of Medicine, 1104 Elliman Bldg., 421 East Canfield, Detroit, MI 48201, United States of America.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0154151PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4956108PMC
July 2017

Anticancer potential of sanguinarine for various human malignancies.

Future Med Chem 2017 06 21;9(9):933-950. Epub 2017 Jun 21.

Translational Research Institute, Hamad Medical Corporation, Doha, Qatar.

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http://dx.doi.org/10.4155/fmc-2017-0041DOI Listing
June 2017

Potential therapeutic targets of Guggulsterone in cancer.

Nutr Metab (Lond) 2017 28;14:23. Epub 2017 Feb 28.

Translational Research Institute, Hamad Medical Corporation, PO Box 3050, Doha, Qatar.

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http://dx.doi.org/10.1186/s12986-017-0180-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5331628PMC
February 2017

Therapeutic Potential of Resveratrol in Lymphoid Malignancies.

Nutr Cancer 2016 30;68(3):365-73. Epub 2016 Mar 30.

b Translational Research Institute, Academic Health System, Hamad Medical Corporation , Doha , Qatar.

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http://dx.doi.org/10.1080/01635581.2016.1152386DOI Listing
January 2017

Targeting acute myeloid leukemia stem cell signaling by natural products.

Mol Cancer 2017 01 30;16(1):13. Epub 2017 Jan 30.

Translational Research Institute, Academic Health System, Hamad Medical Corporation, PO Box 3050, Doha, Qatar.

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http://molecular-cancer.biomedcentral.com/articles/10.1186/s
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http://dx.doi.org/10.1186/s12943-016-0571-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5282735PMC
January 2017

Targeting Cancer at the Nuclear Pore.

J Clin Oncol 2016 12 23;34(34):4180-4182. Epub 2016 Oct 23.

Asfar S. Azmi and Ramzi M. Mohammad, Wayne State University School of Medicine, Detroit, MI.

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http://dx.doi.org/10.1200/JCO.2016.67.5637DOI Listing
December 2016

The Molecular Genetics of Autosomal Recessive Nonsyndromic Intellectual Disability: a Mutational Continuum and Future Recommendations.

Ann Hum Genet 2016 Nov;80(6):342-368

Genomic Core Facility, Translational Research Institute, Academic Health System, Hamad Medical Corporation, Doha, 3050, Qatar.

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http://dx.doi.org/10.1111/ahg.12176DOI Listing
November 2016

Role of leptin and leptin receptors in hematological malignancies.

Leuk Lymphoma 2016 7;57(1):10-6. Epub 2015 Jul 7.

a Translational Research Institute, Academic Health System, Hamad Medical Corporation , Doha , Qatar.

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http://dx.doi.org/10.3109/10428194.2015.1063145DOI Listing
October 2016

The Role of microRNAs in the Diagnosis and Treatment of Pancreatic Adenocarcinoma.

J Clin Med 2016 Jun 16;5(6). Epub 2016 Jun 16.

Department of Oncology, Karmanos Cancer institute, Wayne State University, Detroit, MI 48201, USA.

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http://dx.doi.org/10.3390/jcm5060059DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4929414PMC
June 2016

Measurement of 1,5-anhydroglucitol in blood and saliva: from non-targeted metabolomics to biochemical assay.

J Transl Med 2016 05 18;14(1):140. Epub 2016 May 18.

Translational Research Institute, Academic Health System, Hamad Medical Corporation, PO Box 3050, Doha, Qatar.

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http://dx.doi.org/10.1186/s12967-016-0897-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4870767PMC
May 2016

Involvement of F-BOX proteins in progression and development of human malignancies.

Semin Cancer Biol 2016 Feb 26;36:18-32. Epub 2015 Sep 26.

Academic Health System, Translational Research Institute, Hamad Medical Corporation, Doha, Qatar. Electronic address:

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http://dx.doi.org/10.1016/j.semcancer.2015.09.008DOI Listing
February 2016

F-BOX proteins in cancer cachexia and muscle wasting: Emerging regulators and therapeutic opportunities.

Semin Cancer Biol 2016 Feb 21;36:95-104. Epub 2016 Jan 21.

Department of Oncology, Wayne State University School of Medicine, Karmanos Cancer Institute, Detroit, MI 48201, USA. Electronic address:

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http://dx.doi.org/10.1016/j.semcancer.2016.01.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4761518PMC
February 2016

Designing a broad-spectrum integrative approach for cancer prevention and treatment.

Authors:
Keith I Block Charlotte Gyllenhaal Leroy Lowe Amedeo Amedei A R M Ruhul Amin Amr Amin Katia Aquilano Jack Arbiser Alexandra Arreola Alla Arzumanyan S Salman Ashraf Asfar S Azmi Fabian Benencia Dipita Bhakta Alan Bilsland Anupam Bishayee Stacy W Blain Penny B Block Chandra S Boosani Thomas E Carey Amancio Carnero Marianeve Carotenuto Stephanie C Casey Mrinmay Chakrabarti Rupesh Chaturvedi Georgia Zhuo Chen Helen Chen Sophie Chen Yi Charlie Chen Beom K Choi Maria Rosa Ciriolo Helen M Coley Andrew R Collins Marisa Connell Sarah Crawford Colleen S Curran Charlotta Dabrosin Giovanna Damia Santanu Dasgupta Ralph J DeBerardinis William K Decker Punita Dhawan Anna Mae E Diehl Jin-Tang Dong Q Ping Dou Janice E Drew Eyad Elkord Bassel El-Rayes Mark A Feitelson Dean W Felsher Lynnette R Ferguson Carmela Fimognari Gary L Firestone Christian Frezza Hiromasa Fujii Mark M Fuster Daniele Generali Alexandros G Georgakilas Frank Gieseler Michael Gilbertson Michelle F Green Brendan Grue Gunjan Guha Dorota Halicka William G Helferich Petr Heneberg Patricia Hentosh Matthew D Hirschey Lorne J Hofseth Randall F Holcombe Kanya Honoki Hsue-Yin Hsu Gloria S Huang Lasse D Jensen Wen G Jiang Lee W Jones Phillip A Karpowicz W Nicol Keith Sid P Kerkar Gazala N Khan Mahin Khatami Young H Ko Omer Kucuk Rob J Kulathinal Nagi B Kumar Byoung S Kwon Anne Le Michael A Lea Ho-Young Lee Terry Lichtor Liang-Tzung Lin Jason W Locasale Bal L Lokeshwar Valter D Longo Costas A Lyssiotis Karen L MacKenzie Meenakshi Malhotra Maria Marino Maria L Martinez-Chantar Ander Matheu Christopher Maxwell Eoin McDonnell Alan K Meeker Mahya Mehrmohamadi Kapil Mehta Gregory A Michelotti Ramzi M Mohammad Sulma I Mohammed D James Morre Vinayak Muralidhar Irfana Muqbil Michael P Murphy Ganji Purnachandra Nagaraju Rita Nahta Elena Niccolai Somaira Nowsheen Carolina Panis Francesco Pantano Virginia R Parslow Graham Pawelec Peter L Pedersen Brad Poore Deepak Poudyal Satya Prakash Mark Prince Lizzia Raffaghello Jeffrey C Rathmell W Kimryn Rathmell Swapan K Ray Jörg Reichrath Sarallah Rezazadeh Domenico Ribatti Luigi Ricciardiello R Brooks Robey Francis Rodier H P Vasantha Rupasinghe Gian Luigi Russo Elizabeth P Ryan Abbas K Samadi Isidro Sanchez-Garcia Andrew J Sanders Daniele Santini Malancha Sarkar Tetsuro Sasada Neeraj K Saxena Rodney E Shackelford H M C Shantha Kumara Dipali Sharma Dong M Shin David Sidransky Markus David Siegelin Emanuela Signori Neetu Singh Sharanya Sivanand Daniel Sliva Carl Smythe Carmela Spagnuolo Diana M Stafforini John Stagg Pochi R Subbarayan Tabetha Sundin Wamidh H Talib Sarah K Thompson Phuoc T Tran Hendrik Ungefroren Matthew G Vander Heiden Vasundara Venkateswaran Dass S Vinay Panagiotis J Vlachostergios Zongwei Wang Kathryn E Wellen Richard L Whelan Eddy S Yang Huanjie Yang Xujuan Yang Paul Yaswen Clement Yedjou Xin Yin Jiyue Zhu Massimo Zollo

Semin Cancer Biol 2015 Dec;35 Suppl:S276-S304

Centro di Ingegneria Genetica e Biotecnologia Avanzate, Naples, Italy; Department of Molecular Medicine and Medical Biotechnology, Federico II, Via Pansini 5, 80131 Naples, Italy.

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http://dx.doi.org/10.1016/j.semcancer.2015.09.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4819002PMC
December 2015

Selecting efficacious Bcl-2 family inhibitors for optimal clinical outcome.

Ann Transl Med 2015 Nov;3(20):312

1 Department of Oncology, Karmanos Cancer Institute, Wayne State University, Detroit, MI, USA ; 2 Interim translational Research Institute, Hamad Medical Corporation, Doha, Qatar.

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http://dx.doi.org/10.3978/j.issn.2305-5839.2015.09.15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4669332PMC
November 2015

p21-activated kinase 4: a druggable target in the elusive oncogenic KRAS pathway?

Future Med Chem 2015 ;7(1):5-7

Department of Oncology, Wayne State University School of Medicine, 4100 John R, HWCRC 732, Detroit, MI 48201, USA.

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http://dx.doi.org/10.4155/fmc.14.144DOI Listing
September 2015

Regulation of KRAS-PAK4 axis by microRNAs in cancer.

Curr Pharm Des 2014 ;20(33):5275-8

Department of Pathology, Wayne State University School of Medicine, 4100 John R, HWCRC 732, Detroit MI USA.

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http://dx.doi.org/10.2174/1381612820666140128203452DOI Listing
May 2015

Erratum to: Comparative in vivo evaluations of curcumin and its analog difluorinated curcumin against cisplatin-induced nephrotoxicity.

Biol Trace Elem Res 2015 Mar;164(1):162-3

Department of Animal Nutrition, Faculty of Veterinary Science, Firat University, Elazig, 23100, Turkey,

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http://dx.doi.org/10.1007/s12011-014-0198-yDOI Listing
March 2015

Understanding XPO1 target networks using systems biology and mathematical modeling.

Curr Pharm Des 2014 ;20(1):56-65

Department of Biochemistry, Aligarh Muslim University, Aligarh, 202002, UP India.

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http://dx.doi.org/10.2174/13816128113199990611DOI Listing
September 2014

Differentially expressed miRNAs in cancer-stem-like cells: markers for tumor cell aggressiveness of pancreatic cancer.

Stem Cells Dev 2014 Aug 6;23(16):1947-58. Epub 2014 Jun 6.

1 Department of Pathology, Karmanos Cancer Institute, Wayne State University , Detroit, Michigan.

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http://dx.doi.org/10.1089/scd.2013.0551DOI Listing
August 2014

Snail nuclear transport: the gateways regulating epithelial-to-mesenchymal transition?

Semin Cancer Biol 2014 Aug 17;27:39-45. Epub 2014 Jun 17.

Department of Pathology, Wayne State University, School of Medicine, Detroit, MI, USA. Electronic address:

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http://dx.doi.org/10.1016/j.semcancer.2014.06.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4165636PMC
August 2014

Rectifying cancer drug discovery through network pharmacology.

Future Med Chem 2014 Apr;6(5):529-39

Department of Pathology, Wayne State University, 4100 John R, HWCRC 732, Detroit MI 48201, USA.

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http://dx.doi.org/10.4155/fmc.14.6DOI Listing
April 2014

Comparative in vivo evaluations of curcumin and its analog difluorinated curcumin against cisplatin-induced nephrotoxicity.

Biol Trace Elem Res 2014 Feb 12;157(2):156-63. Epub 2014 Jan 12.

Department of Animal Nutrition, Faculty of Veterinary Science, Firat University, Elazig, 23100, Turkey,

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http://dx.doi.org/10.1007/s12011-014-9886-xDOI Listing
February 2014

Association of PPARγ2 gene variant Pro12Ala polymorphism with hypertension and obesity in the aboriginal Qatari population known for being consanguineous.

Appl Clin Genet 2013 24;6:103-11. Epub 2013 Oct 24.

Department of Medical Statistics and Epidemiology, Hamad Medical Corporation, Department of Public Health, Weill Cornell Medical College, Doha, Qatar ; Department of Evidence for Population Health Unit, School of Epidemiology and Health Sciences, University of Manchester, Manchester, UK.

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http://dx.doi.org/10.2147/TACG.S49875DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3811883PMC
November 2013

Nuclear export mediated regulation of microRNAs: potential target for drug intervention.

Curr Drug Targets 2013 Sep;14(10):1094-100

Department of Biochemistry Faculty of Life Sciences, AMU Aligarh, 202002 UP, India.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4167361PMC
http://dx.doi.org/10.2174/1389450111314100002DOI Listing
September 2013

Systems analysis reveals a transcriptional reversal of the mesenchymal phenotype induced by SNAIL-inhibitor GN-25.

BMC Syst Biol 2013 Sep 3;7:85. Epub 2013 Sep 3.

Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, John R, HWCRC 732, Detroit, MI, 4100, USA.

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http://dx.doi.org/10.1186/1752-0509-7-85DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3848843PMC
September 2013

Selective inhibitors of nuclear export for the treatment of non-Hodgkin's lymphomas.

Haematologica 2013 Jul 12;98(7):1098-106. Epub 2013 Feb 12.

Department of Pathology, Wayne State University, Detroit MI, USA.

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http://dx.doi.org/10.3324/haematol.2012.074781DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3696614PMC
July 2013

Network insights into the genes regulated by hepatocyte nuclear factor 4 in response to drug induced perturbations: a review.

Curr Drug Discov Technol 2013 Jun;10(2):147-54

Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3820112PMC
http://dx.doi.org/10.2174/1570163811310020007DOI Listing
June 2013

Network pharmacology: reigning in drug attrition?

Curr Drug Discov Technol 2013 Jun;10(2):155-9

Department of Oncology, Karmanos Cancer Institute, Wayne State University, 4100 John R, HWCRC, Room 732, MI 48201, USA.

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http://dx.doi.org/10.2174/1570163811310020008DOI Listing
June 2013

Systems and Network Pharmacology Approaches to Cancer Stem Cells Research and Therapy.

J Stem Cell Res Ther 2012 Dec;Suppl 7(5)

Department of Biochemistry, Aligarh Muslim University, Aligarh, Uttar Pradesh, India.

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http://dx.doi.org/10.4172/2157-7633.S7-005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3852409PMC
December 2012

Old wine in a new bottle: the Warburg effect and anticancer mechanisms of resveratrol.

Curr Pharm Des 2012 ;18(12):1645-54

Department of Biochemistry, Aligarh Muslim University, India.

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http://dx.doi.org/10.2174/138161212799958567DOI Listing
October 2012

The complexities of epidemiology and prevention of gastrointestinal cancers.

Int J Mol Sci 2012 Oct 1;13(10):12556-72. Epub 2012 Oct 1.

Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA.

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http://dx.doi.org/10.3390/ijms131012556DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3497287PMC
October 2012

Network insights on oxaliplatin anti-cancer mechanisms.

Clin Transl Med 2012 Oct 29;1(1):26. Epub 2012 Oct 29.

Department of Oncology, Karmanos Cancer Institute, Wayne State University, 4100 John R, HWCRC, Room 732, Detroit, MI, 48201, USA.

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http://dx.doi.org/10.1186/2001-1326-1-26DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3560997PMC
October 2012

Can network pharmacology rescue neutraceutical cancer research?

Drug Discov Today 2012 Aug 16;17(15-16):807-9. Epub 2012 Jun 16.

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http://dx.doi.org/10.1016/j.drudis.2012.06.008DOI Listing
August 2012

Regulation of renal organic anion and cation transporters by thymoquinone in cisplatin induced kidney injury.

Food Chem Toxicol 2012 May 3;50(5):1675-9. Epub 2012 Mar 3.

Department of Nephrology, Faculty of Medicine, Firat University, Elazig, Turkey.

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http://dx.doi.org/10.1016/j.fct.2012.02.082DOI Listing
May 2012

Aberrant epigenetic grooming of miRNAs in pancreatic cancer: a systems biology perspective.

Epigenomics 2011 Dec;3(6):747-59

Department of Pathology & Oncology, Karmanos Cancer Institute, Wayne State University, Detroit, MI 48201, USA.

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http://dx.doi.org/10.2217/epi.11.97DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3243906PMC
December 2011

Network perspectives on HDM2 inhibitor chemotherapy combinations.

Curr Pharm Des 2011 ;17(6):640-52

Department of Pathology, Karmanos Cancer Institute HWCRC Building 732, 4100 John R, Detroit, MI 48201, USA.

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http://dx.doi.org/10.2174/138161211795222612DOI Listing
November 2011

Cell cycle and apoptosis regulatory protein (CARP)-1 is a novel, adriamycin-inducible, diffuse large B-cell lymphoma (DLBL) growth suppressor.

Cancer Chemother Pharmacol 2011 Jun 31;67(6):1401-13. Epub 2010 Aug 31.

Room B4334, Veterans Affairs Medical Center, Wayne State University, 4646 John R, Detroit, MI 48201, USA.

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http://dx.doi.org/10.1007/s00280-010-1442-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3809905PMC
June 2011

Small molecule inhibitors of bcl-2 family proteins for pancreatic cancer therapy.

Cancers (Basel) 2011 Jun;3(2):1527-49

Department of Internal Medicine/Pathology, Karmanos Cancer Institute, Wayne State University, 4100 John R, HWCRC 732, Detroit, MI 48201, USA.

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http://dx.doi.org/10.3390/cancers3021527DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3134295PMC
June 2011

Emerging Bcl-2 inhibitors for the treatment of cancer.

Expert Opin Emerg Drugs 2011 Mar 3;16(1):59-70. Epub 2010 Sep 3.

Wayne State University School of Medicine, 740 Hudson Webber Cancer Research Center, Barbara Ann Karmanos Cancer Institute, Department of Pathology, 4100 John R, Detroit, MI 48201, USA.

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http://dx.doi.org/10.1517/14728214.2010.515210DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3084453PMC
March 2011

Review on molecular and therapeutic potential of thymoquinone in cancer.

Nutr Cancer 2010 ;62(7):938-46

Department of Pathology and Internal Medicine, School of Medicine, Barbara Ann Karmanos Cancer Institute, Wayne State University, Detroit, Michigan 48201, USA.

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http://dx.doi.org/10.1080/01635581.2010.509832DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4167365PMC
January 2011

Progress in nanotechnology based approaches to enhance the potential of chemopreventive agents.

Cancers (Basel) 2011 Jan 21;3(1):428-45. Epub 2011 Jan 21.

Department of Biochemistry, Faculty of Life Sciences, Aligarh Muslim University, Aligarh 202002, UP, India.

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http://dx.doi.org/10.3390/cancers3010428DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3756370PMC
January 2011

Proof of concept: network and systems biology approaches aid in the discovery of potent anticancer drug combinations.

Mol Cancer Ther 2010 Dec 1;9(12):3137-44. Epub 2010 Nov 1.

Department of Pathology, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, 740 Hudson Webber Cancer Research Center, 4100 John R St, Detroit, Michigan 48201, USA.

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http://mct.aacrjournals.org/cgi/doi/10.1158/1535-7163.MCT-10
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http://dx.doi.org/10.1158/1535-7163.MCT-10-0642DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3058926PMC
December 2010

Adamantyl-substituted retinoid-related molecules induce apoptosis in human acute myelogenous leukemia cells.

Mol Cancer Ther 2010 Nov 9;9(11):2903-13. Epub 2010 Nov 9.

John D. Dingell VA Medical Center, Wayne State University, Karmanos Cancer Institute, Oncology 11M-HO, Room C3540, 4646 John R. Street, Detroit, MI 48201, USA.

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http://dx.doi.org/10.1158/1535-7163.MCT-10-0546DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3058343PMC
November 2010

I-kappa-kinase-2 (IKK-2) inhibition potentiates vincristine cytotoxicity in non-Hodgkin's lymphoma.

Mol Cancer 2010 Sep 1;9:228. Epub 2010 Sep 1.

Lymphoma Research Laboratory, Wayne State University-School of Medicine, 540 E, Canfield, 8229 Scott Hall, Detroit, MI 48201, USA.

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http://dx.doi.org/10.1186/1476-4598-9-228DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2940845PMC
September 2010

MDM2 inhibitors for pancreatic cancer therapy.

Mini Rev Med Chem 2010 Jun;10(6):518-26

Hematology and Oncology, Internal Medicine, Wayne State University School of Medicine, Karmanos Cancer Institute, 732 HWCRC, 4100 John R Street, Detroit, MI 48201, USA.

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http://dx.doi.org/10.2174/138955710791384054DOI Listing
June 2010

Structure-activity studies on therapeutic potential of Thymoquinone analogs in pancreatic cancer.

Pharm Res 2010 Jun 27;27(6):1146-58. Epub 2010 Apr 27.

Department of Pathology, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan 48201, USA.

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http://dx.doi.org/10.1007/s11095-010-0145-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3093961PMC
June 2010

PAR-4 as a possible new target for pancreatic cancer therapy.

Expert Opin Ther Targets 2010 Jun;14(6):611-20

Department of Pathology, Wayne State University School of Medicine, Detroit, MI 48201, USA.

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http://dx.doi.org/10.1517/14728222.2010.487066DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2883466PMC
June 2010

Reactivation of p53 by novel MDM2 inhibitors: implications for pancreatic cancer therapy.

Curr Cancer Drug Targets 2010 May;10(3):319-31

Department of Pathology, Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, MI 48201, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3809102PMC
http://dx.doi.org/10.2174/156800910791190229DOI Listing
May 2010

MDM2 inhibitor MI-319 in combination with cisplatin is an effective treatment for pancreatic cancer independent of p53 function.

Eur J Cancer 2010 Apr 13;46(6):1122-31. Epub 2010 Feb 13.

Department of Pathology, Karmanos Cancer Institute, Wayne State University, School of Medicine, Detroit, MI, United States.

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http://dx.doi.org/10.1016/j.ejca.2010.01.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4106027PMC
April 2010

An MDM2 antagonist (MI-319) restores p53 functions and increases the life span of orally treated follicular lymphoma bearing animals.

Mol Cancer 2009 Dec 3;8:115. Epub 2009 Dec 3.

Division of Hematology and Oncology, Department of Internal Medicine, Karmanos Cancer Institute, Wayne State University School of Medicine, 732 HWCRC, 4100 John R Street, Detroit, Michigan 48201, USA.

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http://dx.doi.org/10.1186/1476-4598-8-115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2794250PMC
December 2009

New targets for the treatment of follicular lymphoma.

J Hematol Oncol 2009 Dec 23;2:50. Epub 2009 Dec 23.

Department of Internal Medicine, Division of Hematology/Oncology, Wayne State University School of Medicine, Detroit, Michigan, USA.

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http://dx.doi.org/10.1186/1756-8722-2-50DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2805680PMC
December 2009

Plumbagin induces cell death through a copper-redox cycle mechanism in human cancer cells.

Mutagenesis 2009 Sep 7;24(5):413-8. Epub 2009 Jun 7.

Department of Biochemistry, Faculty of Life Sciences, Aligarh Muslim University, Aligarh 202002, Uttar Pradesh, India.

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http://dx.doi.org/10.1093/mutage/gep023DOI Listing
September 2009

Antitumor activity of gemcitabine and oxaliplatin is augmented by thymoquinone in pancreatic cancer.

Cancer Res 2009 Jul 23;69(13):5575-83. Epub 2009 Jun 23.

Department of Pathology, Barbara Ann Karmanos Cancer Institute, Wayne State University School of Medicine, Detroit, Michigan, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-08-4235DOI Listing
July 2009

Superior antitumor activity of SAR3419 to rituximab in xenograft models for non-Hodgkin's lymphoma.

Clin Cancer Res 2009 Jun 9;15(12):4038-45. Epub 2009 Jun 9.

Lymphoma Research Laboratory, Wayne State University School of Medicine, Detroit, Michigan 48202, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-08-2808DOI Listing
June 2009

SMI of Bcl-2 TW-37 is active across a spectrum of B-cell tumors irrespective of their proliferative and differentiation status.

J Hematol Oncol 2009 Feb 16;2. Epub 2009 Feb 16.

Department of Internal Medicine, Division of Hematology/Oncology, Wayne State University School of Medicine, Detroit, Michigan, USA.

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http://jhoonline.biomedcentral.com/articles/10.1186/1756-872
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http://dx.doi.org/10.1186/1756-8722-2-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2651908PMC
February 2009

From here to eternity - the secret of Pharaohs: Therapeutic potential of black cumin seeds and beyond.

Cancer Ther 2008 ;6(b):495-510

Department of Pathology and Division of Internal Medicine, Barbara Ann Karmanos Cancer Institute, Wayne State University, School of Medicine, Detroit, MI- 48201, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2583426PMC
January 2008