Publications by authors named "Ramon Diaz-Arrastia"

99Publications

Imaging biomarkers of vascular and axonal injury are spatially distinct in chronic traumatic brain injury.

J Cereb Blood Flow Metab 2021 Jan 14:271678X20985156. Epub 2021 Jan 14.

Department of Neurology, University of Pennsylvania, Perelman School of Medicine, Philadelphia, PA, USA.

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January 2021

Assessing the Severity of Traumatic Brain Injury-Time for a Change?

J Clin Med 2021 Jan 4;10(1). Epub 2021 Jan 4.

Concussion Care Centre of Virginia and Tree of Life, Richmond, VA 23233, USA.

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January 2021

Smaller Regional Brain Volumes Predict Posttraumatic Stress Disorder at 3 Months After Mild Traumatic Brain Injury.

Biol Psychiatry Cogn Neurosci Neuroimaging 2020 Oct 27. Epub 2020 Oct 27.

Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California; Department of Bioengineering and Therapeutic Sciences, University of California San Francisco, San Francisco, California.

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October 2020

Advances in traumatic brain injury research in 2020.

Lancet Neurol 2021 Jan;20(1):5-7

Department of Neurology, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address:

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January 2021

Recent Advances in Blood-Based Biomarkers of Remote Combat-Related Traumatic Brain Injury.

Curr Neurol Neurosci Rep 2020 Sep 28;20(12):54. Epub 2020 Sep 28.

National Intrepid Center of Excellence, Walter Reed National Military Medical Center, Bethesda, MD, USA.

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September 2020

Neurofilament light as a biomarker in traumatic brain injury.

Neurology 2020 08 8;95(6):e610-e622. Epub 2020 Jul 8.

From the NIH (P.S., A.P., Y.-Y.C., D.L.P., J.A.B., J.M.G., D.L.B., L.C.); Center for Neuroscience and Regenerative Medicine (P.S., A.v.d.M., B.M., Y.-Y.C., D.L.P., J.A.B., J.M.G., D.L.B., L.C.); The Henry M. Jackson Foundation for the Advancement of Military Medicine (P.S., A.v.d.M., B.M., J.M.G., D.L.B.), Bethesda, MD; Department of Psychiatry and Neurochemistry (P.S., H.Z., K.B.), Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg; Clinical Neurochemistry Laboratory (P.S., H.Z., K.B.), Sahlgrenska University Hospital, Mölndal, Sweden; Uniformed Services University of the Health Sciences (D.L.B.), Bethesda, MD; Department of Neurology (R.D.-A.), University of Pennsylvania, Philadelphia; UK Dementia Research Institute at UCL (H.Z.); and Department of Neurodegenerative Disease (H.Z.), UCL Institute of Neurology, London, UK.

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August 2020

Time course and diagnostic utility of NfL, tau, GFAP, and UCH-L1 in subacute and chronic TBI.

Neurology 2020 08 8;95(6):e623-e636. Epub 2020 Jul 8.

From the NIH (P.S., A.P., S.M.L., Y.-Y.C., D.L.P., J.A.B., J.M.G., D.L.B., L.C.); Center for Neuroscience and Regenerative Medicine (P.S., A.v.d.M., B.M., V.E., Y.-Y.C., D.L.P., J.A.B., J.M.G., D.L.B., L.C.); The Henry M. Jackson Foundation for the Advancement of Military Medicine (P.S., A.v.d.M., B.M., V.E., D.L.B.), Bethesda, MD; Department of Psychiatry and Neurochemistry (P.S., H.Z., K.B.), Institute of Neuroscience and Physiology, Sahlgrenska Academy at University of Gothenburg; Clinical Neurochemistry Laboratory (P.S., H.Z., K.B.), Sahlgrenska University Hospital, Mölndal, Sweden; National Intrepid Center of Excellence (S.M.L.) and Defense and Veterans Brain Injury Center (S.M.L.), Walter Reed National Military Medical Center, Bethesda, MD; Department of Neurology (R.D.-A.), University of Pennsylvania, Philadelphia; UK Dementia Research Institute at UCL (H.Z.); Department of Neurodegenerative Disease (H.Z.), UCL Institute of Neurology, London, UK; and Uniformed Services University of the Health Sciences (D.L.B.), Bethesda, MD.

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August 2020

Is Salivary S100B a Biomarker of Traumatic Brain Injury? A Pilot Study.

Front Neurol 2020 12;11:528. Epub 2020 Jun 12.

Department of Neurology, University of Pennsylvania, Philadelphia, PA, United States.

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June 2020

Blood biomarkers of traumatic brain injury and cognitive impairment in older veterans.

Neurology 2020 09 22;95(9):e1126-e1133. Epub 2020 Jun 22.

From San Francisco Veterans Affairs Health Care System (C.B.P., R.C.G., K.Y.), CA; Northern California Institute for Research and Education (C.B.P.), San Francisco; Uniformed Services University of the Health Sciences (K.K.), Rockville; NIH (J.G.), Bethesda, MD; Department of Neurology (R.D.-A.), University of Pennsylvania, Philadelphia; and Departments of Neurology (R.C.G., K.Y.), Psychiatry (K.Y.), and Epidemiology and Biostatistics (K.Y.), University of California, San Francisco.

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September 2020

Unravelling the mechanisms of blood-brain barrier dysfunction in repetitive mild head injury.

Brain 2020 06;143(6):1625-1628

University of Pennsylvania Perelman School of Medicine, Philadelphia, USA.

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June 2020

Impaired cerebral blood flow regulation in chronic traumatic brain injury.

Brain Res 2020 Sep 4;1743:146924. Epub 2020 Jun 4.

Department of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, TX 75390, USA; Institute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital Dallas, 8200 Walnut Hill Ln, Dallas, TX 75231, USA.

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September 2020

Exosomal neurofilament light: A prognostic biomarker for remote symptoms after mild traumatic brain injury?

Neurology 2020 06 27;94(23):e2412-e2423. Epub 2020 May 27.

From the National Institute of Nursing Research (V.A.G., C.L., C.D., J.M.G.), National Institute of Neurological Disorders and Stroke (P.S.), and Center for Neuroscience and Regenerative Medicine (P.S., J.M.G.) and Department of Neurology (K.K., B.-X.Q.), Uniformed Services University of the Health Sciences, NIH; Walter Reed National Military Medical Center (K.K.), National Intrepid Center of Excellence, Bethesda, MD; Department of Physical Medicine & Rehabilitation (W.C.W.), Virginia Commonwealth University, Richmond; RTI International (T.N.), Research Triangle Park, NC; and Department of Neurology (R.D.-A.), University of Pennsylvania, Philadelphia.

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June 2020

Relationship of Cerebral Blood Flow to Cognitive Function and Recovery in Early Chronic Traumatic Brain Injury.

J Neurotrauma 2020 Oct 11;37(20):2180-2187. Epub 2020 Jun 11.

Department of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania, USA.

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October 2020

Circulating Neurofilament Light Chain Is Associated With Survival After Pediatric Cardiac Arrest.

Pediatr Crit Care Med 2020 07;21(7):656-661

Department of Neurology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.

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July 2020

Unsupervised Machine Learning Reveals Novel Traumatic Brain Injury Patient Phenotypes with Distinct Acute Injury Profiles and Long-Term Outcomes.

J Neurotrauma 2020 06 11;37(12):1431-1444. Epub 2020 Mar 11.

Department of Anesthesiology and Critical Care Medicine, and Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.

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June 2020

Molecular biomarkers in the neurological ICU: is there a role?

Curr Opin Crit Care 2020 04;26(2):103-108

Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.

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April 2020

Assessment of cerebrovascular dysfunction after traumatic brain injury with fMRI and fNIRS.

Neuroimage Clin 2020 11;25:102086. Epub 2019 Nov 11.

Center for Neuroscience and Regenerative Medicine, Department of Neurology, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814, USA; Department of Neurology, University of Pennsylvania Perelman School of Medicine, Philadelphia.

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January 2021

Increased severity of the CHIMERA model induces acute vascular injury, sub-acute deficits in memory recall, and chronic white matter gliosis.

Exp Neurol 2020 02 15;324:113116. Epub 2019 Nov 15.

Djavad Mowafaghian Centre for Brain Health, Department of Pathology and Laboratory Medicine, University of British Columbia, 2215 Wesbrook Mall, Vancouver V6T 1Z3, BC, Canada. Electronic address:

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February 2020

Surgical Outcomes in Post-Traumatic Epilepsy: A Single Institutional Experience.

Oper Neurosurg (Hagerstown) 2020 01;18(1):12-18

Department of Neurosurgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.

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January 2020

Risk of Posttraumatic Stress Disorder and Major Depression in Civilian Patients After Mild Traumatic Brain Injury: A TRACK-TBI Study.

JAMA Psychiatry 2019 03;76(3):249-258

Department of Physical Medicine and Rehabilitation, Harvard Medical School, Boston, Massachusetts.

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March 2019

Biomarkers in traumatic brain injury (TBI): a review.

Neuropsychiatr Dis Treat 2018 8;14:2989-3000. Epub 2018 Nov 8.

FloTBI Inc., Cleveland, OH, USA,

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November 2018

Discordance between Documented Criteria and Documented Diagnosis of Traumatic Brain Injury in the Emergency Department.

J Neurotrauma 2019 04 4;36(8):1335-1342. Epub 2018 Dec 4.

1 Stroke Diagnostics and Therapeutics Section, National Institutes of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland.

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April 2019

Glial fibrillary acidic protein elevations relate to neuroimaging abnormalities after mild TBI.

Neurology 2018 10 12;91(15):e1385-e1389. Epub 2018 Sep 12.

From the National Institutes of Health (J.G., V.M., C.D.), National Institute of Nursing Research, the Center for Neuroscience and Regenerative Medicine (J.G., P.S.), Uniformed Services University of the Health Sciences, Biomarker Core, and the National Institutes of Health (L.L., C.T.), National Institute of Neurological Disorders and Stroke, Bethesda, MD; the Department of Neurology (R.D.-A.), University of Pennsylvania, Philadelphia, PA; the Department of Biomedical and Dental Sciences and Morphofunctional Imaging (S.M.), University of Messina, Italy; and the Quanterix Corporation (E.V., D.H., L.S., A.J.), Lexington, MA.

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October 2018

Glial fibrillary acidic protein elevations relate to neuroimaging abnormalities after mild TBI.

Neurology 2018 10 12;91(15):e1385-e1389. Epub 2018 Sep 12.

From the National Institutes of Health (J.G., V.M., C.D.), National Institute of Nursing Research, the Center for Neuroscience and Regenerative Medicine (J.G., P.S.), Uniformed Services University of the Health Sciences, Biomarker Core, and the National Institutes of Health (L.L., C.T.), National Institute of Neurological Disorders and Stroke, Bethesda, MD; the Department of Neurology (R.D.-A.), University of Pennsylvania, Philadelphia, PA; the Department of Biomedical and Dental Sciences and Morphofunctional Imaging (S.M.), University of Messina, Italy; and the Quanterix Corporation (E.V., D.H., L.S., A.J.), Lexington, MA.

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October 2018

Testing a Multivariate Proteomic Panel for Traumatic Brain Injury Biomarker Discovery: A TRACK-TBI Pilot Study.

J Neurotrauma 2019 01 27;36(1):100-110. Epub 2018 Sep 27.

1 Department of Neurological Surgery, University of California San Francisco, Zuckerberg San Francisco General Hospital and Trauma Center, and the Brain and Spinal Injury Center, University of California San Francisco, San Francisco, California.

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January 2019

Evolution of Traumatic Parenchymal Intracranial Hematomas (ICHs): Comparison of Hematoma and Edema Components.

Front Neurol 2018 4;9:527. Epub 2018 Jul 4.

Department of Neurology, Penn Presbyterian Medical Center, University of Pennsylvania, Philadelphia, PA, United States.

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July 2018

Risk of Dementia Outcomes Associated With Traumatic Brain Injury During Military Service.

JAMA Neurol 2018 09;75(9):1043-1044

Department of Neurology, University of Pennsylvania Perelman School of Medicine, Philadelphia.

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September 2018

Exosomes in Acquired Neurological Disorders: New Insights into Pathophysiology and Treatment.

Mol Neurobiol 2018 Dec 16;55(12):9280-9293. Epub 2018 Apr 16.

National Institutes of Health, National Institute of Nursing Research, 1 Cloister Ct, Bethesda, MD, 20814, USA.

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December 2018

Vascular Abnormalities within Normal Appearing Tissue in Chronic Traumatic Brain Injury.

J Neurotrauma 2018 10 7;35(19):2250-2258. Epub 2018 Jun 7.

1 Department of Neurology, University of Pennsylvania Perelman School of Medicine , Philadelphia, Pennsylvania.

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October 2018

Genomic links between blast exposure, brain injury, and Alzheimer disease.

Neurol Genet 2017 Oct 13;3(5):e196. Epub 2017 Oct 13.

University of Pittsburgh (Y.P.C.), PA; and University of Pennsylvania (R.D.-A.), Penn Presbyterian Medical Center, Philadelphia.

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October 2017

Dementia After Moderate-Severe Traumatic Brain Injury: Coexistence of Multiple Proteinopathies.

J Neuropathol Exp Neurol 2018 Jan;77(1):50-63

Department of Neurology; Department of Pathology, F. Edward Hébert School of Medicine; Center for Neuroscience and Regenerative Medicine (CNRM), Uniformed Services University of the Health Sciences (USUHS), Bethesda, Maryland; The Henry M. Jackson Foundation for the Advancement of Military Research (HJF); Center for Neurotechnology and Neurorecovery, Department of Neurology, Massachusetts General Hospital, Boston Massachusetts; Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, Charlestown, Massachusetts; Department of Neurology; Alzheimer's Disease Center and CTE Program, Boston University School of Medicine, Boston, Massachusetts; Department of Neurology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania;Department of Rehabilitation Medicine; Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, New York; Radiological Sciences Laboratory, Department of Radiology, Stanford University, Stanford, California; Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Boston, Massachusetts; VA Boston Healthcare System, Boston, Massachusetts; and Department of Pathology, Boston University School of Medicine, Boston, Massachusetts.

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January 2018

Imaging of Cerebrovascular Function in Chronic Traumatic Brain Injury.

J Neurotrauma 2018 05 20;35(10):1116-1123. Epub 2018 Mar 20.

2 Department of Neurology, University of Pennsylvania Perelman School of Medicine , Philadelphia, Pennsylvania.

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May 2018

Sildenafil Improves Vascular and Metabolic Function in Patients with Alzheimer's Disease.

J Alzheimers Dis 2017 ;60(4):1351-1364

Department of Neurology and Neurotherapeutics, The University of Texas Southwestern Medical Center, Dallas, TX, USA.

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July 2018

Brain Oxygen Optimization in Severe Traumatic Brain Injury Phase-II: A Phase II Randomized Trial.

Crit Care Med 2017 Nov;45(11):1907-1914

1University of Pittsburgh School of Medicine, Pittsburgh, PA. 2Uniformed Services University of the Health Sciences, Bethesda, MD. 3University of Washington, Seattle, WA. 4UT Southwestern Medical Center, Dallas, TX. 5University of Cincinnati College of Medicine, Cincinnati, OH. 6University of Miami, Miller School of Medicine, Miami, FL. 7Stanford University, Stanford, CA. 8Ohio State University College of Medicine, Columbus, OH. 9Temple University, Philadelphia, PA. 10Thomas Jefferson University, Philadelphia, PA. 11Lankenau Medical Center, Wynnewood, PA. 12Moberg Research, Ambler, PA. 13Baylor St. Luke's Medical Center, Houston, TX. 14Department of Neurology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA.

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November 2017

The chronic and evolving neurological consequences of traumatic brain injury.

Lancet Neurol 2017 10 12;16(10):813-825. Epub 2017 Sep 12.

Department of Public Health, Erasmus Medical Center Rotterdam, Rotterdam, Netherlands.

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October 2017

Plasma creatine kinase B correlates with injury severity and symptoms in professional boxers.

J Clin Neurosci 2017 Nov 7;45:100-104. Epub 2017 Aug 7.

Department of Surgery, University of Texas Southwestern Medical Center, Dallas, TX 75390, United States; Department of Neurological Surgery, University of Texas Southwestern Medical Center, Dallas, TX 75390, United States. Electronic address:

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November 2017

Heterozygous knockout of cytosolic phospholipase A attenuates Alzheimer's disease pathology in APP/PS1 transgenic mice.

Brain Res 2017 Sep 23;1670:248-252. Epub 2017 Jun 23.

Center for Neuroscience and Regenerative Medicine, Department of Neurology, Uniformed Services University of the Health Sciences, Bethesda, MD, United States.

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September 2017

Remote Traumatic Brain Injury Is Associated with Motor Dysfunction in Older Military Veterans.

J Gerontol A Biol Sci Med Sci 2017 Sep;72(9):1233-1238

Memory and Aging Center, Department of Neurology, University of California San Francisco.

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September 2017

Reliability of the NINDS common data elements cranial tomography (CT) rating variables for traumatic brain injury (TBI).

Brain Inj 2017 12;31(2):174-184. Epub 2016 Dec 12.

a Center for Neuroscience & Regenerative Medicine , Uniformed Services University of Health Sciences, Rockville , MD , USA.

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January 2018

Natural History of Headache Five Years after Traumatic Brain Injury.

J Neurotrauma 2017 04 18;34(8):1558-1564. Epub 2017 Jan 18.

1 Department of Rehabilitation Medicine, University of Washington Medical Center , Seattle, Washington.

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April 2017

Localized cortical chronic traumatic encephalopathy pathology after single, severe axonal injury in human brain.

Acta Neuropathol 2017 03 24;133(3):353-366. Epub 2016 Nov 24.

Department of Pathology, F. Edward Hébert School of Medicine, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD, 20814, USA.

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March 2017

Duration of Posttraumatic Amnesia Predicts Neuropsychological and Global Outcome in Complicated Mild Traumatic Brain Injury.

J Head Trauma Rehabil 2016 Nov/Dec;31(6):E1-E9

Moss Rehabilitation Research Institute, Elkins Park, Pennsylvania (Dr Hart); Department of Physical Medicine and Rehabilitation, University of Alabama at Birmingham (Dr Novack); Neurological Surgery and Biostatistics (Dr Temkin), Neurological Surgery (Mr Barber), Department of Rehabilitation Medicine, (Dr Dikmen), University of Washington, Seattle; Department of Neurology, Uniformed Services University of the Health Sciences, Bethesda, Maryland (Dr Diaz-Arrastia); Department of Rehabilitation Medicine, NYU School of Medicine, New York (Dr Ricker); GH Sergievsky Center and Department of Epidemiology, Columbia University, New York (Dr Hesdorffer); Department of Neurosurgery, Thomas Jefferson University, Philadelphia, Pennsylvania (Dr Jallo); Department of Physical Medicine & Rehabilitation, Virginia Commonwealth University, Richmond, Virginia (Dr Hsu); and Spaulding Rehabilitation Hospital, Massachusetts General Hospital, Brigham and Women's Hospital, and Harvard Medical School, Boston (Dr Zafonte).

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March 2018

Emergency Department Evaluation of Traumatic Brain Injury in the United States, 2009-2010.

J Head Trauma Rehabil 2016 Nov/Dec;31(6):379-387

Department of Emergency Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland (Drs Korley and Kelen); The School of Medicine and Dentistry, University of Rochester, Rochester, New York (Dr Jones); and Center for Neuroscience and Regenerative Medicine, Uniformed Services University of the Health Sciences, Bethesda, Maryland (Dr Diaz-Arrastia).

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March 2018

Fluid Biomarkers of Traumatic Brain Injury and Intended Context of Use.

Diagnostics (Basel) 2016 Oct 18;6(4). Epub 2016 Oct 18.

Director, Traumatic Brain Injury Clinical Research Center, Department of Neurology, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA 19104, USA.

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October 2016

Neuropsychological Profile of Lifetime Traumatic Brain Injury in Older Veterans.

J Int Neuropsychol Soc 2017 01 4;23(1):56-64. Epub 2016 Oct 4.

5Departments of Psychiatry,Neurology,and Epidemiology and Biostatistics,University of California San Francisco and San Francisco VA Healthcare System,San Francisco,California.

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January 2017

Seizures and the Role of Anticonvulsants After Traumatic Brain Injury.

Neurosurg Clin N Am 2016 Oct;27(4):499-508

Department of Neurosurgery, Ronald Reagan UCLA Medical Center, 757 Westwood Plaza, Suite 6236, Los Angeles, CA 90095, USA.

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October 2016

Neurobehavioral Characteristics of Older Veterans With Remote Traumatic Brain Injury.

J Head Trauma Rehabil 2017 Jan/Feb;32(1):E8-E15

San Francisco VA Medical Center, San Francisco, California (Drs Peltz, Gardner, and Yaffe); NCIRE-The Veterans Health Research Institute, San Francisco, California (Drs Peltz and Yaffe); University of California, San Francisco (Drs Gardner, Kramer, and Yaffe); and Uniformed Services University of the Health Sciences, Rockville, Maryland (Drs Kenney and Diaz-Arrastia).

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February 2018

Increases of Plasma Levels of Glial Fibrillary Acidic Protein, Tau, and Amyloid β up to 90 Days after Traumatic Brain Injury.

J Neurotrauma 2017 01 8;34(1):66-73. Epub 2016 Jul 8.

1 Center for Neuroscience and Regenerative Medicine, Uniformed Services University of the Health Sciences , Rockville, Maryland.

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January 2017

Candidate PET Radioligand Development for Neurofibrillary Tangles: Two Distinct Radioligand Binding Sites Identified in Postmortem Alzheimer's Disease Brain.

ACS Chem Neurosci 2016 07 19;7(7):897-911. Epub 2016 May 19.

Molecular Imaging Branch, National Institute of Mental Health, National Institutes of Health , Bethesda, Maryland 20892, United States.

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July 2016