Publications by authors named "Rami Aqeilan"

100Publications

Programmed DNA Damage and Physiological DSBs: Mapping, Biological Significance and Perturbations in Disease States.

Cells 2020 Aug 10;9(8). Epub 2020 Aug 10.

The Concern Foundation Laboratories, The Lautenberg Center for Immunology and Cancer Research, Department of Immunology and Cancer Research-IMRIC, Hebrew University-Hadassah Medical School, Jerusalem 9112001, Israel.

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http://dx.doi.org/10.3390/cells9081870DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7463922PMC
August 2020

Twist1-induced miR-199a-3p promotes liver fibrosis by suppressing caveolin-2 and activating TGF-β pathway.

Signal Transduct Target Ther 2020 Jun 5;5(1):75. Epub 2020 Jun 5.

Department of Gastroenterology & Hepatology, West China Hospital, Sichuan University, Chengdu, 610041, China.

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http://dx.doi.org/10.1038/s41392-020-0169-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7272438PMC
June 2020

Mapping the breakome reveals tight regulation on oncogenic super-enhancers.

Mol Cell Oncol 2020 11;7(3):1698933. Epub 2020 Feb 11.

The Lautenberg Center for General and Tumor Immunology; Department of Immunology and Cancer Research-IMRIC, Hebrew University-Hadassah Medical School, Jerusalem, Israel.

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http://dx.doi.org/10.1080/23723556.2019.1698933DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7199745PMC
February 2020

Pleiotropic tumor suppressor functions of WWOX antagonize metastasis.

Signal Transduct Target Ther 2020 Apr 17;5(1):43. Epub 2020 Apr 17.

Lautenberg Center for Immunology and Cancer Research, Hebrew University-Hadassah Medical School, IMRIC, Jerusalem, Israel.

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http://dx.doi.org/10.1038/s41392-020-0136-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7162874PMC
April 2020

Activation of Oncogenic Super-Enhancers Is Coupled with DNA Repair by RAD51.

Cell Rep 2019 10;29(3):560-572.e4

Lautenberg Center for Immunology and Cancer Research, Institute for Medical Research Israel-Canada, Hebrew University-Hadassah Medical School, Jerusalem, Israel; Department of Cancer Biology and Genetics, Wexner Medical Center, Ohio State University, Columbus, Ohio, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2019.09.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6899447PMC
October 2019

AntimiR-155 Cyclic Peptide-PNA Conjugate: Synthesis, Cellular Uptake, and Biological Activity.

ACS Omega 2019 Aug 12;4(9):13954-13961. Epub 2019 Aug 12.

The Institute for Drug Research, The School of Pharmacy, and Lautenberg Center for Immunology and Cancer Research, Institute for Medical Research Israel-Canada, The Hebrew University of Jerusalem, Hadassah Ein-Kerem, Jerusalem 9112102, Israel.

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http://dx.doi.org/10.1021/acsomega.9b01697DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6714607PMC
August 2019

Editorial: WW Domain Proteins in Signaling, Cancer Growth, Neural Diseases, and Metabolic Disorders.

Front Oncol 2019 2;9:719. Epub 2019 Aug 2.

Faculty of Medicine, The Lautenberg Center for Immunology and Cancer Research, Institute for Medical Research, Israel-Canada (IMRIC), Hebrew University of Jerusalem, Jerusalem, Israel.

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http://dx.doi.org/10.3389/fonc.2019.00719DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6688159PMC
August 2019

Decoding the link between WWOX and p53 in aggressive breast cancer.

Cell Cycle 2019 06 16;18(11):1177-1186. Epub 2019 May 16.

a Lautenberg Center for Immunology and Cancer Research, IMRIC , Hebrew University-Hadassah Medical School, IMRIC , Jerusalem , Israel.

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http://dx.doi.org/10.1080/15384101.2019.1616998DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6592247PMC
June 2019

MiR-16-1-3p and miR-16-2-3p possess strong tumor suppressive and antimetastatic properties in osteosarcoma.

Int J Cancer 2019 12 9;145(11):3052-3063. Epub 2019 May 9.

The Lautenberg Center for General and Tumor Immunology, Department of Immunology and Cancer Research-IMRIC, The Hebrew University-Hadassah Medical School at Ein-Kerem, Jerusalem, Israel.

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http://dx.doi.org/10.1002/ijc.32368DOI Listing
December 2019

WWOX somatic ablation in skeletal muscles alters glucose metabolism.

Mol Metab 2019 04 31;22:132-140. Epub 2019 Jan 31.

The Lautenberg Center for General and Tumor Immunology, Department of Immunology and Cancer Research-IMRIC, Hebrew University-Hadassah Medical School, Jerusalem, Israel; Department of Cancer Biology and Genetics, Wexner Medical Center, The Ohio State University, Columbus, OH, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molmet.2019.01.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437662PMC
April 2019

WWOX Inhibits Metastasis of Triple-Negative Breast Cancer Cells via Modulation of miRNAs.

Cancer Res 2019 Apr 8;79(8):1784-1798. Epub 2019 Jan 8.

Lautenberg Center for Immunology and Cancer Research, Hebrew University-Hadassah Medical School, IMRIC, Jerusalem, Israel.

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http://dx.doi.org/10.1158/0008-5472.CAN-18-0614DOI Listing
April 2019

Author Correction: WWOX controls hepatic HIF1α to suppress hepatocyte proliferation and neoplasia.

Cell Death Dis 2018 Nov 23;9(12):1159. Epub 2018 Nov 23.

The Lautenberg Center for General and Tumor Immunology, Department of Immunology and Cancer Research-IMRIC, Hebrew University-Hadassah Medical School, Jerusalem, Israel.

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http://www.nature.com/articles/s41419-018-1158-9
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http://dx.doi.org/10.1038/s41419-018-1158-9DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6251905PMC
November 2018

Modeling WWOX Loss of Function : What Have We Learned?

Front Oncol 2018 10;8:420. Epub 2018 Oct 10.

Faculty of Medicine, The Lautenberg Center for Immunology and Cancer Research, Institute for Medical Research, Israel-Canada (IMRIC), Hebrew University of Jerusalem, Jerusalem, Israel.

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https://www.frontiersin.org/article/10.3389/fonc.2018.00420/
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http://dx.doi.org/10.3389/fonc.2018.00420DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6194312PMC
October 2018

Somatic loss of WWOX is associated with TP53 perturbation in basal-like breast cancer.

Cell Death Dis 2018 08 6;9(8):832. Epub 2018 Aug 6.

Lautenberg Center for Immunology and Cancer Research, IMRIC, Hebrew University-Hadassah Medical School, IMRIC, Jerusalem, Israel.

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http://dx.doi.org/10.1038/s41419-018-0896-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6079009PMC
August 2018

Microenvironmental Cues Determine Tumor Cell Susceptibility to Neutrophil Cytotoxicity.

Cancer Res 2018 09 2;78(17):5050-5059. Epub 2018 Jul 2.

Department of Developmental Biology and Cancer Research, Institute for Medical Research Israel-Canada, Hebrew University Medical School, Jerusalem, Israel.

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http://dx.doi.org/10.1158/0008-5472.CAN-18-0540DOI Listing
September 2018

MicroRNA-214 promotes hepatic stellate cell activation and liver fibrosis by suppressing Sufu expression.

Cell Death Dis 2018 06 18;9(7):718. Epub 2018 Jun 18.

Department of Thoracic Surgery, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, and Collaborative Innovation Center for Biotherapy, 610041, Chengdu, China.

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http://dx.doi.org/10.1038/s41419-018-0752-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6006298PMC
June 2018

WWOX controls hepatic HIF1α to suppress hepatocyte proliferation and neoplasia.

Cell Death Dis 2018 05 1;9(5):511. Epub 2018 May 1.

The Lautenberg Center for General and Tumor Immunology, Department of Immunology and Cancer Research-IMRIC, Hebrew University-Hadassah Medical School, Jerusalem, Israel.

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http://dx.doi.org/10.1038/s41419-018-0510-4DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5938702PMC
May 2018

TRPM2 Mediates Neutrophil Killing of Disseminated Tumor Cells.

Cancer Res 2018 05 28;78(10):2680-2690. Epub 2018 Feb 28.

Department of Developmental Biology and Cancer Research, Institute for Medical Research Israel-Canada, Hebrew University Medical School, Jerusalem, Israel.

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http://cancerres.aacrjournals.org/lookup/doi/10.1158/0008-54
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http://dx.doi.org/10.1158/0008-5472.CAN-17-3614DOI Listing
May 2018

Combined shRNA over CRISPR/cas9 as a methodology to detect off-target effects and a potential compensatory mechanism.

Sci Rep 2018 01 8;8(1):93. Epub 2018 Jan 8.

Department of Developmental Biology and Cancer Research, The Institute for Medical Research, Faculty of Medicine, The Hebrew University, Ein Kerem, P.O. Box 12271, Jerusalem, 91120, Israel.

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http://dx.doi.org/10.1038/s41598-017-18551-zDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5758708PMC
January 2018

TCL1A interacts with TP63 and enhances the survival of Raji Burkitt lymphoma cell line.

Br J Haematol 2018 11 19;183(3):509-512. Epub 2017 Oct 19.

Department of Experimental and Clinical Medicine, University 'Magna Graecia' of Catanzaro, Catanzaro, Italy.

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http://dx.doi.org/10.1111/bjh.14989DOI Listing
November 2018

RUNX1, a new regulator of EMT in breast cancer.

Oncotarget 2017 03;8(11):17407-17408

Lautenberg Center for Immunology and Cancer Research, IMRIC, Hebrew University-Hadassah Medical School, Jerusalem.

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http://dx.doi.org/10.18632/oncotarget.15623DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5392256PMC
March 2017

Tumor Suppressor Genes within Common Fragile Sites Are Active Players in the DNA Damage Response.

PLoS Genet 2016 Dec 15;12(12):e1006436. Epub 2016 Dec 15.

Lautenberg Center for Immunology and Cancer Research, IMRIC, Hebrew University-Hadassah Medical School, Jerusalem, Israel.

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http://dx.doi.org/10.1371/journal.pgen.1006436DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5157955PMC
December 2016

WWOX and p53 Dysregulation Synergize to Drive the Development of Osteosarcoma.

Cancer Res 2016 10 22;76(20):6107-6117. Epub 2016 Aug 22.

The Lautenberg Center for Immunology and Cancer Research, IMRIC, Faculty of Medicine, Hebrew University of Jerusalem, Israel. Department of Cancer Biology and Genetics (CBG), The Ohio State University Wexner Medical Center, Columbus, Ohio. Department of Biochemistry, University of Vermont College of Medicine, Burlington, Vermont.

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http://dx.doi.org/10.1158/0008-5472.CAN-16-0621DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5146760PMC
October 2016

WWOX guards genome stability by activating ATM.

Mol Cell Oncol 2015 Oct-Dec;2(4):e1008288. Epub 2015 Feb 23.

The Lautenberg Center for General and Tumor Immunology; Department of Immunology and Cancer Research-IMRIC; Hebrew University-Hadassah Medical School ; Jerusalem, Israel.

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http://dx.doi.org/10.1080/23723556.2015.1008288DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4905350PMC
June 2016

Genetic factors conferring metastasis in osteosarcoma.

Future Oncol 2016 Jul 13;12(13):1623-44. Epub 2016 Apr 13.

Lautenberg Center for Immunology & Cancer Research, IMRIC, Hebrew University-Hadassah Medical School, Jerusalem 91120, Israel.

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http://dx.doi.org/10.2217/fon-2016-0014DOI Listing
July 2016

WWOX modulates the ATR-mediated DNA damage checkpoint response.

Oncotarget 2016 Jan;7(4):4344-55

Lautenberg Center for Immunology and Cancer Research, IMRIC, Hebrew University-Hadassah Medical School, Jerusalem 91120, Israel.

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http://dx.doi.org/10.18632/oncotarget.6571DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4826209PMC
January 2016

Pleiotropic Functions of Tumor Suppressor WWOX in Normal and Cancer Cells.

J Biol Chem 2015 Dec 23;290(52):30728-35. Epub 2015 Oct 23.

From the Departments of Immunology & Cancer Research and

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http://dx.doi.org/10.1074/jbc.R115.676346DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4692203PMC
December 2015

Tumor Suppressor WWOX inhibits osteosarcoma metastasis by modulating RUNX2 function.

Sci Rep 2015 Aug 10;5:12959. Epub 2015 Aug 10.

The Lautenberg Center for Immunology and Cancer Research, IMRIC, Faculty of Medicine, Hebrew University of Jerusalem, Israel 91220.

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http://dx.doi.org/10.1038/srep12959DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4542681PMC
August 2015

WWOX loss activates aerobic glycolysis.

Mol Cell Oncol 2015 Apr-Jun;2(2):e965640. Epub 2014 Oct 30.

The Lautenberg Center for General and Tumor Immunology; Department of Immunology and Cancer Research-IMRIC; Hebrew University-Hadassah Medical School; Jerusalem, Israel; Human Cancer Genetics Program; Ohio State University Comprehensive Cancer Center; Columbus, OH USA.

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http://dx.doi.org/10.4161/23723548.2014.965640DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4904998PMC
June 2016

miR-27a and miR-27a* contribute to metastatic properties of osteosarcoma cells.

Oncotarget 2015 Mar;6(7):4920-35

The Lautenberg Center for Immunology and Cancer Research, IMRIC, Hebrew University-Hadassah Medical School, Jerusalem, Israel.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4467124PMC
http://dx.doi.org/10.18632/oncotarget.3025DOI Listing
March 2015

T538 phosphorylation, Pin-ing p63-Itch stability.

Cell Cycle 2015 ;14(4):469-70

a Faculty of Biology ; Technion - Israel Institute of Technology ; Haifa , Israel.

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http://dx.doi.org/10.1080/15384101.2015.1006553DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4615061PMC
September 2015

The tumor suppressor WW domain-containing oxidoreductase modulates cell metabolism.

Exp Biol Med (Maywood) 2015 Mar 8;240(3):345-50. Epub 2014 Dec 8.

The Lautenberg Center for General and Tumor Immunology, Department of Immunology and Cancer Research-IMRIC, Hebrew University-Hadassah Medical School, Jerusalem 91220, Israel Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA

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http://dx.doi.org/10.1177/1535370214561956DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4935230PMC
March 2015

The ubiquitin E3 ligase ITCH enhances breast tumor progression by inhibiting the Hippo tumor suppressor pathway.

Oncotarget 2014 Nov;5(21):10886-900

The Lautenberg Center for Immunology and Cancer Research, IMRIC, Hebrew University-Hadassah Medical School, Jerusalem, Israel. Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4279417PMC
http://dx.doi.org/10.18632/oncotarget.2540DOI Listing
November 2014

FHIT suppresses epithelial-mesenchymal transition (EMT) and metastasis in lung cancer through modulation of microRNAs.

PLoS Genet 2014 Oct 23;10(10):e1004652. Epub 2014 Oct 23.

Department of Molecular Virology, Immunology and Medical Genetics, and Comprehensive Cancer Center, Ohio State University, Columbus, Ohio, United States of America.

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http://dx.doi.org/10.1371/journal.pgen.1004652DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4207614PMC
October 2014

WWOX, the common fragile site FRA16D gene product, regulates ATM activation and the DNA damage response.

Proc Natl Acad Sci U S A 2014 Nov 20;111(44):E4716-25. Epub 2014 Oct 20.

The Lautenberg Center for General and Tumor Immunology, Department of Immunology and Cancer Research-Institute for Medical Research Israel-Canada, Hebrew University-Hadassah Medical School, Jerusalem 91120, Israel;

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http://dx.doi.org/10.1073/pnas.1409252111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4226089PMC
November 2014

Epigenetic pathways regulating bone homeostasis: potential targeting for intervention of skeletal disorders.

Curr Osteoporos Rep 2014 Dec;12(4):496-506

Department of Biochemistry and Vermont Cancer Center, University of Vermont College of Medicine, 89 Beaumont Avenue, Burlington, VT, USA.

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http://link.springer.com/10.1007/s11914-014-0240-1
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http://dx.doi.org/10.1007/s11914-014-0240-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4216616PMC
December 2014

The common fragile site FRA16D gene product WWOX: roles in tumor suppression and genomic stability.

Cell Mol Life Sci 2014 Dec 23;71(23):4589-99. Epub 2014 Sep 23.

The Lautenberg Center for Immunology and Cancer Research, IMRIC, Faculty of Medicine, Hebrew University of Jerusalem, 91220, Jerusalem, Israel,

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http://dx.doi.org/10.1007/s00018-014-1724-yDOI Listing
December 2014

Role of common fragile sites and corresponding genes in cancer development.

Authors:
Rami I Aqeilan

Cell Mol Life Sci 2014 Dec 20;71(23):4487-8. Epub 2014 Sep 20.

The Lautenberg Center for Immunology and Cancer Research, IMRIC, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem, Israel, 91220,

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http://dx.doi.org/10.1007/s00018-014-1716-yDOI Listing
December 2014

The WWOX gene modulates high-density lipoprotein and lipid metabolism.

Circ Cardiovasc Genet 2014 Aug 28;7(4):491-504. Epub 2014 May 28.

From the Cardiovascular Research Laboratories, Department of Biochemistry, Faculty of Medicine, Division of Cardiology, McGill University, Royal Victoria Hospital, Montreal, Quebec, Canada (I.I., H.Y.C., I.R., Z.A., J.G.); Department of Human Genetics (M.V.P.L.R., D.W.-V., E.N., P.P.) and Department of Medicine (M.V.P.L.R., D.W.-V., E.N., P.P.), David Geffen School of Medicine at University of California at Los Angeles; Department of Molecular Carcinogenesis, University of Texas MD Anderson Cancer Center, Smithville (H.K., J.L., C.M.A.); The Lautenberg Cancer Research Center, Department of Immunology and Cancer Research, IMRIC, Hebrew University-Hadassah Medical School, Jerusalem, Israel (M.A.O., M.A.-R., R.I.A.); The Lautenberg Center for Immunology and Cancer Research, Department of Immunology and Cancer Research-IMRIC, Hebrew University-Hadassah Medical School, Jerusalem, Israel and Al-Quds-Bard College for Arts and Sciences, Al-Quds University, East Jerusalem-Abu Dis, Palestine (Z.S.); and Department of Molecular Virology, Immunology and Medical Genetics, Ohio State University, Columbus (M.C., C.M.C., R.I.A.).

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http://dx.doi.org/10.1161/CIRCGENETICS.113.000248DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4315188PMC
August 2014

Characterizing WW domain interactions of tumor suppressor WWOX reveals its association with multiprotein networks.

J Biol Chem 2014 Mar 18;289(13):8865-80. Epub 2014 Feb 18.

From the Lautenberg Center for Immunology and Cancer Research, IMRIC, Hebrew University-Hadassah Medical School, Jerusalem, Israel 91120.

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http://dx.doi.org/10.1074/jbc.M113.506790DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3979411PMC
March 2014

WW domain-containing oxidoreductase's role in myriad cancers: clinical significance and future implications.

Exp Biol Med (Maywood) 2014 Mar 7;239(3):253-63. Epub 2014 Feb 7.

Albert Einstein College of Medicine, Bronx, NY 10461, USA.

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http://dx.doi.org/10.1177/1535370213519213DOI Listing
March 2014

Fhit delocalizes annexin a4 from plasma membrane to cytosol and sensitizes lung cancer cells to paclitaxel.

PLoS One 2013 6;8(11):e78610. Epub 2013 Nov 6.

Department of Molecular Immunology, Virology and Medical Genetics, The Ohio State University, Columbus, Ohio, United States of America ; Lymphoma and Genomics Research Program, IOR Institute of Oncology Research, Bellinzona, Switzerland ; Dipartimento di Medicina Sperimentale e Clinica, University Magna Græcia, Campus "S. Venuta", Catanzaro, Italy.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0078610PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3819369PMC
August 2014

NEDD4 E3 ligase inhibits the activity of the Hippo pathway by targeting LATS1 for degradation.

Cell Cycle 2013 Dec 7;12(24):3817-23. Epub 2013 Oct 7.

The Lautenberg Center for Immunology and Cancer Research; IMRIC; Hebrew University-Hadassah Medical School; Jerusalem, Israel.

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http://www.tandfonline.com/doi/abs/10.4161/cc.26672
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http://dx.doi.org/10.4161/cc.26672DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3905073PMC
December 2013

Characterization of WWOX inactivation in murine mammary gland development.

J Cell Physiol 2013 Jul;228(7):1391-6

Lautenberg Center for Immunology and Cancer Research, IMRIC, Hebrew University-Hadassah Medical School, Jerusalem, Israel.

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http://dx.doi.org/10.1002/jcp.24310DOI Listing
July 2013

Biophysical basis of the binding of WWOX tumor suppressor to WBP1 and WBP2 adaptors.

J Mol Biol 2012 Sep 23;422(1):58-74. Epub 2012 May 23.

Department of Biochemistry and Molecular Biology, Leonard Miller School of Medicine, University of Miami, Miami, FL 33136, USA.

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http://dx.doi.org/10.1016/j.jmb.2012.05.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3412936PMC
September 2012

MicroRNAs/TP53 feedback circuitry in glioblastoma multiforme.

Proc Natl Acad Sci U S A 2012 Apr 19;109(14):5316-21. Epub 2012 Mar 19.

Department of Molecular Virology, Immunology, and Medical Genetics, Comprehensive Cancer Center, Ohio State University, Columbus, OH 43210, USA.

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http://dx.doi.org/10.1073/pnas.1202465109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3325690PMC
April 2012

miRNA signatures associate with pathogenesis and progression of osteosarcoma.

Cancer Res 2012 Apr 20;72(7):1865-77. Epub 2012 Feb 20.

Department of Orthopaedics and Center for Children's Cancer Research, Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-11-2663DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3328547PMC
April 2012

MicroRNAs: New Players in Multiple Myeloma.

Front Genet 2011 24;2:22. Epub 2011 May 24.

Department of Molecular Virology, Immunology and Medical Genetics, Ohio State University Columbus, OH, USA.

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http://journal.frontiersin.org/article/10.3389/fgene.2011.00
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http://dx.doi.org/10.3389/fgene.2011.00022DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3268577PMC
October 2012

WW domain-containing proteins: retrospectives and the future.

Front Biosci (Landmark Ed) 2012 Jan 1;17:331-48. Epub 2012 Jan 1.

The Lautenberg Center for General and Tumor Immunology, Department of Immunology and Cancer Research-IMRIC, Hebrew University-Hadassah Medical School, Jerusalem 91120, Israel.

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http://dx.doi.org/10.2741/3930DOI Listing
January 2012

Common fragile site tumor suppressor genes and corresponding mouse models of cancer.

J Biomed Biotechnol 2011 29;2011:984505. Epub 2010 Dec 29.

Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University, Columbus, OH 43210, USA.

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http://dx.doi.org/10.1155/2011/984505DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3035048PMC
June 2011

Negative regulation of the Hippo pathway by E3 ubiquitin ligase ITCH is sufficient to promote tumorigenicity.

Cancer Res 2011 Mar 6;71(5):2010-20. Epub 2011 Jan 6.

The Lautenberg Center for Immunology and Cancer Research, IMRIC, Hebrew University-Hadassah Medical School, Jerusalem, Israel.

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http://dx.doi.org/10.1158/0008-5472.CAN-10-3516DOI Listing
March 2011

The tumor suppressor gene WWOX links the canonical and noncanonical NF-κB pathways in HTLV-I Tax-mediated tumorigenesis.

Blood 2011 Feb 29;117(5):1652-61. Epub 2010 Nov 29.

University of Pittsburgh Cancer Institute, Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, PA 15213, USA.

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http://dx.doi.org/10.1182/blood-2010-08-303073DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3318777PMC
February 2011

Cell death or survival promoted by alternative isoforms of ErbB4.

Mol Biol Cell 2010 Dec 13;21(23):4275-86. Epub 2010 Oct 13.

Department of Medical Biochemistry and Genetics, and Medicity Research Laboratory, University of Turku, Turku, Finland; Department of Oncology, Turku University Hospital, FIN-20520 Turku, Finland.

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http://dx.doi.org/10.1091/mbc.E10-04-0332DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2993754PMC
December 2010

WWOX gene and gene product: tumor suppression through specific protein interactions.

Future Oncol 2010 Feb;6(2):249-59

The Lautenberg Center for Immunology, Institute for Medical Research Israel-Canada, The Hebrew University-Hadassah Medical School, Pharmacy Building, Jerusalem 91120, Israel.

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http://dx.doi.org/10.2217/fon.09.152DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2832309PMC
February 2010

WWOX: its genomics, partners, and functions.

J Cell Biochem 2009 Nov;108(4):737-45

The Lautenberg Center for General and Tumor Immunology, Institute for Medical Research Israel-Canada, The Hebrew University-Hadassah Medical School, Jerusalem 91120, Israel.

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http://dx.doi.org/10.1002/jcb.22298DOI Listing
November 2009

Targeted disruption of the murine homeodomain-interacting protein kinase-2 causes growth deficiency in vivo and cell cycle arrest in vitro.

DNA Cell Biol 2009 Apr;28(4):161-7

Department of Molecular Virology, Immunology and Medical Genetics and Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio, USA.

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http://dx.doi.org/10.1089/dna.2008.0778DOI Listing
April 2009

Biological functions of miR-29b contribute to positive regulation of osteoblast differentiation.

J Biol Chem 2009 Jun 2;284(23):15676-84. Epub 2009 Apr 2.

Department of Cell Biology and Cancer Center, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA.

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http://www.jbc.org/lookup/doi/10.1074/jbc.M809787200
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http://dx.doi.org/10.1074/jbc.M809787200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2708864PMC
June 2009

The WWOX tumor suppressor is essential for postnatal survival and normal bone metabolism.

J Biol Chem 2008 Aug 16;283(31):21629-39. Epub 2008 May 16.

Department of Molecular Virology, Immunology, and Medical Genetics, Human Cancer Genetics Program and Comprehensive Cancer Center, Ohio State University, Columbus, OH 43210, USA.

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http://dx.doi.org/10.1074/jbc.M800855200DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2490770PMC
August 2008

Role of the WWOX gene, encompassing fragile region FRA16D, in suppression of pancreatic carcinoma cells.

Cancer Sci 2008 Jul 2;99(7):1370-6. Epub 2008 May 2.

Division of Pathology, Department of Pathology, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan.

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http://dx.doi.org/10.1111/j.1349-7006.2008.00841.xDOI Listing
July 2008

MiR-15a and miR-16-1 cluster functions in human leukemia.

Proc Natl Acad Sci U S A 2008 Apr 24;105(13):5166-71. Epub 2008 Mar 24.

Human Cancer Genetics Program and Department of Molecular Virology, Immunology, and Medical Genetics, Ohio State University, Columbus, OH 43210, USA.

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http://dx.doi.org/10.1073/pnas.0800121105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2278188PMC
April 2008

Isoform-specific monoubiquitination, endocytosis, and degradation of alternatively spliced ErbB4 isoforms.

Proc Natl Acad Sci U S A 2008 Mar 11;105(11):4162-7. Epub 2008 Mar 11.

MediCity Research Laboratory and Department of Medical Biochemistry and Molecular Biology, University of Turku, FIN-20520 Turku, Finland.

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http://dx.doi.org/10.1073/pnas.0708333105DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2393780PMC
March 2008

Association of Wwox with ErbB4 in breast cancer.

Cancer Res 2007 Oct;67(19):9330-6

Department of Molecular Virology, Immunology and Medical Genetics, Human Cancer Genetics Program, Comprehensive Cancer Center, Ohio State University, Columbus, Ohio 43210, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-07-2147DOI Listing
October 2007

The Nedd4-binding partner 1 (N4BP1) protein is an inhibitor of the E3 ligase Itch.

Proc Natl Acad Sci U S A 2007 Jul 25;104(27):11280-5. Epub 2007 Jun 25.

Biochemistry Laboratory, Istituto Dermopatico dell'Immacolata-Istituto di Ricovero e Cura a Carattere Scientifico, University of Rome Tor Vergata, 00133 Rome, Italy.

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http://dx.doi.org/10.1073/pnas.0701773104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2040890PMC
July 2007

Cleavage of the transactivation-inhibitory domain of p63 by caspases enhances apoptosis.

Proc Natl Acad Sci U S A 2007 Jun 20;104(26):10871-6. Epub 2007 Jun 20.

*Medical Research Council, Toxicology Unit, Leicester University, Leicester LE1 9HN, United Kingdom.

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http://dx.doi.org/10.1073/pnas.0700761104DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1904122PMC
June 2007

Inactivation of the Wwox gene accelerates forestomach tumor progression in vivo.

Cancer Res 2007 Jun;67(12):5606-10

Division of Human Cancer Genetics, Department of Molecular Virology, Immunology and Medical Genetics, Ohio State University, Columbus, Ohio 43210, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-07-1081DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2621009PMC
June 2007

WWOX in biological control and tumorigenesis.

J Cell Physiol 2007 Aug;212(2):307-10

Department of Molecular Virology, Immunology and Medical Genetics, Human Cancer Genetics Program, Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio 43210, USA.

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http://dx.doi.org/10.1002/jcp.21099DOI Listing
August 2007

Targeted deletion of Wwox reveals a tumor suppressor function.

Proc Natl Acad Sci U S A 2007 Mar 27;104(10):3949-54. Epub 2007 Feb 27.

Department of Molecular Virology, Immunology, and Medical Genetics, Comprehensive Cancer Center, Ohio State University, 410 West 12th Avenue, Columbus, OH 43210, USA.

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http://www.pnas.org/cgi/doi/10.1073/pnas.0609783104
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1820689PMC
March 2007

WWOX expression in different histologic types and subtypes of non-small cell lung cancer.

Clin Cancer Res 2007 Feb;13(3):884-91

Department of Surgery, Division of Anatomic Pathology and Cardio-Thoracic Surgery, University of Pisa and Scuola Normale Superiore and Istituto Nazionale di Fisica Nucleare, Section of Pisa, Pisa, Italy.

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http://clincancerres.aacrjournals.org/cgi/doi/10.1158/1078-0
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http://dx.doi.org/10.1158/1078-0432.CCR-06-2016DOI Listing
February 2007

Physical association with WWOX suppresses c-Jun transcriptional activity.

Cancer Res 2006 Dec;66(24):11585-9

Department of Molecular Virology, Immunology, and Medical Genetics, Human Cancer Genetics Program, Comprehensive Cancer Center, Ohio State University, Columbus, Ohio 43210, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-06-3376DOI Listing
December 2006

Animal models for chronic lymphocytic leukemia.

J Cell Biochem 2007 Apr;100(5):1109-18

Comprehensive Cancer Center, Human Cancer Genetics Program, Department of Molecular Virology, Immunology and Medical Genetics, OSU School of Medicine, Ohio State University, Columbus, Ohio 43210, USA.

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http://dx.doi.org/10.1002/jcb.21147DOI Listing
April 2007

The E3 ubiquitin ligase Itch controls the protein stability of p63.

Proc Natl Acad Sci U S A 2006 Aug 14;103(34):12753-8. Epub 2006 Aug 14.

Medical Research Council, Toxicology Unit, Leicester University, Leicester LE1 9HN, United Kingdom.

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http://www.pnas.org/cgi/doi/10.1073/pnas.0603449103
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1550770PMC
August 2006

Tal1 transgenic expression reveals absence of B lymphocytes.

Cancer Res 2006 Jun;66(12):6014-7

Comprehensive Cancer Center, Human Cancer Genetics Program, OSU School of Medicine, Ohio State University, Columbus, Ohio 43210, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-06-0937DOI Listing
June 2006

Akt phosphorylates and regulates Pdcd4 tumor suppressor protein.

Cancer Res 2005 Dec;65(24):11282-6

Comprehensive Cancer Center, Human Cancer Genetics Program, and Department of Molecular Virology, Immunology, and Medical Genetics, Ohio State University School of Medicine, Columbus, 43210, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-05-3469DOI Listing
December 2005

WWOX gene restoration prevents lung cancer growth in vitro and in vivo.

Proc Natl Acad Sci U S A 2005 10 13;102(43):15611-6. Epub 2005 Oct 13.

Department of Molecular Virology, Immunology, and Medical Genetics, Comprehensive Cancer Center, Ohio State University, 410 West 12th Avenue, Columbus, OH 43201, USA.

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http://dx.doi.org/10.1073/pnas.0505485102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1266103PMC
October 2005

Effect of IL-2-Bax, a novel interleukin-2-receptor-targeted chimeric protein, on bleomycin lung injury.

Int J Exp Pathol 2005 Oct;86(5):279-88

Lung Cellular and Molecular Biology Laboratory, Institute of Pulmonology, Hadassah University Hospital and Hebrew University, Hadassah Medical School, Jerusalem, Israel.

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http://dx.doi.org/10.1111/j.0959-9673.2005.00436.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2517439PMC
October 2005

miR-15 and miR-16 induce apoptosis by targeting BCL2.

Proc Natl Acad Sci U S A 2005 Sep 15;102(39):13944-9. Epub 2005 Sep 15.

Department of Molecular Virology, Immunology, and Medical Genetics and Comprehensive Cancer Center, Ohio State University, Columbus OH 43210, USA.

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http://dx.doi.org/10.1073/pnas.0506654102DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1236577PMC
September 2005

WW domain-containing proteins, WWOX and YAP, compete for interaction with ErbB-4 and modulate its transcriptional function.

Cancer Res 2005 Aug;65(15):6764-72

Human Cancer Genetics Program, Department of Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, Ohio State University, Columbus, Ohio 43220, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-05-1150DOI Listing
August 2005

Akt phosphorylates Tal1 oncoprotein and inhibits its repressor activity.

Cancer Res 2005 Jun;65(11):4515-9

Human Cancer Genetics Program, Comprehensive Cancer Center, Ohio State University, Columbus, Ohio 43210, USA.

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http://dx.doi.org/10.1158/0008-5472.CAN-05-0751DOI Listing
June 2005