Publications by authors named "Ramesh Shivdasani"

100Publications

Cellular and molecular architecture of the intestinal stem cell niche.

Nat Cell Biol 2020 Sep 3;22(9):1033-1041. Epub 2020 Sep 3.

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.

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http://dx.doi.org/10.1038/s41556-020-0567-zDOI Listing
September 2020

Epigenetic regulation of intestinal stem cell differentiation.

Am J Physiol Gastrointest Liver Physiol 2020 08 6;319(2):G189-G196. Epub 2020 Jul 6.

Department of Medical Oncology and Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, Massachusetts.

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http://dx.doi.org/10.1152/ajpgi.00084.2020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7500269PMC
August 2020

Hedgehog-Activated Fat4 and PCP Pathways Mediate Mesenchymal Cell Clustering and Villus Formation in Gut Development.

Dev Cell 2020 03;52(5):647-658.e6

Program in Developmental & Stem Cell Biology, the Hospital for Sick Children, Toronto, ON M5G 0A4, Canada; Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A8, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.devcel.2020.02.003DOI Listing
March 2020

Ascl2-Dependent Cell Dedifferentiation Drives Regeneration of Ablated Intestinal Stem Cells.

Cell Stem Cell 2020 03 20;26(3):377-390.e6. Epub 2020 Feb 20.

Department of Medical Oncology and Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Departments of Medicine, Brigham & Women's Hospital and Harvard Medical School, Boston, MA 02215, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2019.12.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7147146PMC
March 2020

Distinct Mesenchymal Cell Populations Generate the Essential Intestinal BMP Signaling Gradient.

Cell Stem Cell 2020 03 20;26(3):391-402.e5. Epub 2020 Feb 20.

Department of Medical Oncology and Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA; Harvard Stem Cell Institute, Cambridge, MA 02139, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2020.01.008DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7412576PMC
March 2020

Replicational Dilution of H3K27me3 in Mammalian Cells and the Role of Poised Promoters.

Mol Cell 2020 04 5;78(1):141-151.e5. Epub 2020 Feb 5.

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2020.01.017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7376365PMC
April 2020

Krüppel-like Factor 5 Regulates Stemness, Lineage Specification, and Regeneration of Intestinal Epithelial Stem Cells.

Cell Mol Gastroenterol Hepatol 2020 25;9(4):587-609. Epub 2019 Nov 25.

Department of Medicine, Stony Brook University Renaissance School of Medicine, Stony Brook, New York; Department of Physiology and Biophysics, Stony Brook University Renaissance School of Medicine, Stony Brook, New York. Electronic address:

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http://dx.doi.org/10.1016/j.jcmgh.2019.11.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7078555PMC
November 2019

Extensive Recovery of Embryonic Enhancer and Gene Memory Stored in Hypomethylated Enhancer DNA.

Mol Cell 2019 05 21;74(3):542-554.e5. Epub 2019 Mar 21.

Department of Medical Oncology and Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Medicine, Brigham & Women's Hospital, Boston, MA 02215, USA; Department of Medicine, Harvard Medical School, Boston, MA 02115, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2019.02.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6499659PMC
May 2019

Dissecting Cell Lineages: From Microscope to Kaleidoscope.

Cell 2019 02;176(5):949-951

Department of Medical Oncology and Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Departments of Medicine, Brigham & Women's Hospital and Harvard Medical School, Boston, MA 02215, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2019.01.054DOI Listing
February 2019

Enhancer, transcriptional, and cell fate plasticity precedes intestinal determination during endoderm development.

Genes Dev 2018 11 26;32(21-22):1430-1442. Epub 2018 Oct 26.

Department of Medical Oncology, Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA.

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http://genesdev.cshlp.org/lookup/doi/10.1101/gad.318832.118
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http://dx.doi.org/10.1101/gad.318832.118DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6217732PMC
November 2018

Limited gut cell repertoire for multiple hormones.

Nat Cell Biol 2018 08;20(8):865-867

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.

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http://dx.doi.org/10.1038/s41556-018-0153-9DOI Listing
August 2018

Transcription factor-dependent 'anti-repressive' mammalian enhancers exclude H3K27me3 from extended genomic domains.

Genes Dev 2017 12 10;31(23-24):2391-2404. Epub 2018 Jan 10.

Department of Medical Oncology, Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA.

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http://dx.doi.org/10.1101/gad.308536.117DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5795785PMC
December 2017

Dynamic Reorganization of Chromatin Accessibility Signatures during Dedifferentiation of Secretory Precursors into Lgr5+ Intestinal Stem Cells.

Cell Stem Cell 2017 07 22;21(1):65-77.e5. Epub 2017 Jun 22.

Department of Medical Oncology and Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Medicine, Harvard Medical School, Boston, MA 02215, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA; Department of Medicine, Brigham and Women's Hospital, Boston, MA 02215, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2017.05.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5505276PMC
July 2017

Natural Selection, Crypt Fitness, and Pol III Dependency in the Intestine.

Cell Mol Gastroenterol Hepatol 2016 Nov 26;2(6):714-715. Epub 2016 Sep 26.

Department of Medical Oncology and Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.

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http://dx.doi.org/10.1016/j.jcmgh.2016.09.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5247341PMC
November 2016

ARID1A loss impairs enhancer-mediated gene regulation and drives colon cancer in mice.

Nat Genet 2017 Feb 12;49(2):296-302. Epub 2016 Dec 12.

Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1038/ng.3744DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5285448PMC
February 2017

Transcriptional Regulator CNOT3 Defines an Aggressive Colorectal Cancer Subtype.

Cancer Res 2017 02 29;77(3):766-779. Epub 2016 Nov 29.

Department of Medical Oncology and Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, Massachusetts.

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http://dx.doi.org/10.1158/0008-5472.CAN-16-1346DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5290184PMC
February 2017

Single-Cell Transcript Profiles Reveal Multilineage Priming in Early Progenitors Derived from Lgr5(+) Intestinal Stem Cells.

Cell Rep 2016 08 11;16(8):2053-2060. Epub 2016 Aug 11.

Department of Medical Oncology and Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Medicine, Harvard Medical School, Boston, MA 02215, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.07.056DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5001892PMC
August 2016

Sox2 Suppresses Gastric Tumorigenesis in Mice.

Cell Rep 2016 08 4;16(7):1929-41. Epub 2016 Aug 4.

Cancer Center and Center for Regenerative Medicine, Massachusetts General Hospital, Boston, MA 02114, USA; Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA; Howard Hughes Medical Institute and Department of Stem Cell and Regenerative Biology, 7 Divinity Avenue, Harvard University, Cambridge, MA 02138, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2016.07.034DOI Listing
August 2016

NF-E2, FLI1 and RUNX1 collaborate at areas of dynamic chromatin to activate transcription in mature mouse megakaryocytes.

Sci Rep 2016 07 26;6:30255. Epub 2016 Jul 26.

Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA 02215, USA.

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http://dx.doi.org/10.1038/srep30255DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4960521PMC
July 2016

Co-culture of Gastric Organoids and Immortalized Stomach Mesenchymal Cells.

Methods Mol Biol 2016 ;1422:23-31

Department of Molecular and Cellular Physiology, University of Cincinnati College of Medicine, 231 Albert B. Sabin Way, Room 4255 MSB, Cincinnati, OH, 45267-0576, USA.

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http://dx.doi.org/10.1007/978-1-4939-3603-8_3DOI Listing
December 2017

Acquired Tissue-Specific Promoter Bivalency Is a Basis for PRC2 Necessity in Adult Cells.

Cell 2016 Jun 19;165(6):1389-1400. Epub 2016 May 19.

Department of Medical Oncology and Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Medicine, Brigham and Women's Hospital, Boston, MA 02215, USA; Department of Medicine, Harvard Medical School, Boston, MA 02215, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2016.04.031DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4893000PMC
June 2016

Stomach development, stem cells and disease.

Development 2016 Feb;143(4):554-65

Department of Medical Oncology and Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA 02215, USA Department of Medicine, Brigham & Women's Hospital and Harvard Medical School, Boston, MA 02215, USA

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http://dev.biologists.org/content/develop/143/4/554.full.pdf
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http://dx.doi.org/10.1242/dev.124891DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4760317PMC
February 2016

SOX15 governs transcription in human stratified epithelia and a subset of esophageal adenocarcinomas.

Cell Mol Gastroenterol Hepatol 2015 Nov;1(6):598-609.e6

Department of Medical Oncology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02215, USA ; Department of Medicine, Harvard Medical School, 45 Shattuck Street, Boston, MA 02115, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S2352345X150014
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http://dx.doi.org/10.1016/j.jcmgh.2015.07.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4620585PMC
November 2015

Distinct Processes and Transcriptional Targets Underlie CDX2 Requirements in Intestinal Stem Cells and Differentiated Villus Cells.

Stem Cell Reports 2015 Nov 17;5(5):673-681. Epub 2015 Oct 17.

Department of Medical Oncology and Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02215, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stemcr.2015.09.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4649135PMC
November 2015

Control of stomach smooth muscle development and intestinal rotation by transcription factor BARX1.

Dev Biol 2015 Sep 6;405(1):21-32. Epub 2015 Jun 6.

Department of Medical Oncology, Dana-Farber Cancer Institute, 450 Brookline Avenue, Boston, MA 02215, USA; Departments of Medicine, Brigham & Women's Hospital and Harvard Medical School, 450 Brookline Avenue, Boston, MA 02215, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00121606150032
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http://dx.doi.org/10.1016/j.ydbio.2015.05.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4529797PMC
September 2015

The use of murine-derived fundic organoids in studies of gastric physiology.

J Physiol 2015 Apr 19;593(8):1809-27. Epub 2015 Feb 19.

Department of Molecular and Cellular Physiology, University of Cincinnati College of Medicine, Cincinnati, OH, USA.

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http://dx.doi.org/10.1113/jphysiol.2014.283028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4405744PMC
April 2015

Transcription factors GATA4 and HNF4A control distinct aspects of intestinal homeostasis in conjunction with transcription factor CDX2.

J Biol Chem 2015 Jan 8;290(3):1850-60. Epub 2014 Dec 8.

From the Department of Medical Oncology and Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, the Department of Genetics, Rutgers, The State University of New Jersey, Piscataway, New Jersey 08854

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http://dx.doi.org/10.1074/jbc.M114.620211DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4340426PMC
January 2015

Active enhancers are delineated de novo during hematopoiesis, with limited lineage fidelity among specified primary blood cells.

Genes Dev 2014 Aug;28(16):1827-39

Department of Medical Oncology, Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA; Harvard Stem Cell Institute, Cambridge, Massachusetts 02138, USA

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http://dx.doi.org/10.1101/gad.240101.114DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4197967PMC
August 2014

Dissecting engineered cell types and enhancing cell fate conversion via CellNet.

Cell 2014 Aug;158(4):889-902

Stem Cell Transplantation Program, Division of Pediatric Hematology and Oncology, Manton Center for Orphan Disease Research, Howard Hughes Medical Institute, Boston Children's Hospital and Dana Farber Cancer Institute, Boston, MA 02115, USA; Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2014.07.021DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4291075PMC
August 2014

Indian Hedgehog mediates gastrin-induced proliferation in stomach of adult mice.

Gastroenterology 2014 Sep 20;147(3):655-666.e9. Epub 2014 May 20.

Department of Molecular and Cellular Physiology, University of Cincinnati College of Medicine, Cincinnati, Ohio. Electronic address:

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http://dx.doi.org/10.1053/j.gastro.2014.05.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4211430PMC
September 2014

Wnt secretion from epithelial cells and subepithelial myofibroblasts is not required in the mouse intestinal stem cell niche in vivo.

Stem Cell Reports 2014 Feb 30;2(2):127-34. Epub 2014 Jan 30.

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA ; Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02215, USA.

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http://dx.doi.org/10.1016/j.stemcr.2013.12.012DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3923227PMC
February 2014

Radiation redux: reserve intestinal stem cells miss the call to duty.

Cell Stem Cell 2014 Feb;14(2):135-6

Department of Medical Oncology and Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Medicine, Brigham & Women's Hospital, Boston, MA 02215, USA; Department of Medicine, Harvard Medical School, Boston, MA 02215, USA. Electronic address:

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http://dx.doi.org/10.1016/j.stem.2014.01.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3955177PMC
February 2014

Broadly permissive intestinal chromatin underlies lateral inhibition and cell plasticity.

Nature 2014 Feb 12;506(7489):511-5. Epub 2014 Jan 12.

1] Department of Medical Oncology and Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, Massachusetts 02215, USA [2] Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02215, USA.

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http://dx.doi.org/10.1038/nature12903DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4151315PMC
February 2014

p63-expressing cells are the stem cells of developing prostate, bladder, and colorectal epithelia.

Proc Natl Acad Sci U S A 2013 May 25;110(20):8105-10. Epub 2013 Apr 25.

Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1073/pnas.1221216110DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3657776PMC
May 2013

DOT1L-mediated H3K79 methylation in chromatin is dispensable for Wnt pathway-specific and other intestinal epithelial functions.

Mol Cell Biol 2013 May 19;33(9):1735-45. Epub 2013 Feb 19.

Department of Medical Oncology and Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1128/MCB.01463-12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3624170PMC
May 2013

Genetics and diet regulate vitamin A production via the homeobox transcription factor ISX.

J Biol Chem 2013 Mar 7;288(13):9017-27. Epub 2013 Feb 7.

Department of Pharmacology, Case Western Reserve University, School of Medicine, Cleveland, OH 44106, USA.

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http://dx.doi.org/10.1074/jbc.M112.444240DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3610974PMC
March 2013

Intestinal master transcription factor CDX2 controls chromatin access for partner transcription factor binding.

Mol Cell Biol 2013 Jan 5;33(2):281-92. Epub 2012 Nov 5.

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1128/MCB.01185-12DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3554120PMC
January 2013

Stem cell niches: famished Paneth cells, gluttonous stem cells.

Curr Biol 2012 Jul;22(14):R579-80

Department of Medical Oncology and Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA 02215, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S09609822120066
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http://dx.doi.org/10.1016/j.cub.2012.06.017DOI Listing
July 2012

GEFs on the RhoAd to a colossal nucleus.

Dev Cell 2012 Mar;22(3):471-2

Dana-Farber Cancer Institute, Brigham and Women's Hospital, and Harvard Medical School, Boston, MA 02215, USA.

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https://linkinghub.elsevier.com/retrieve/pii/S15345807120009
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http://dx.doi.org/10.1016/j.devcel.2012.02.010DOI Listing
March 2012

Intact function of Lgr5 receptor-expressing intestinal stem cells in the absence of Paneth cells.

Proc Natl Acad Sci U S A 2012 Mar 21;109(10):3932-7. Epub 2012 Feb 21.

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.

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http://dx.doi.org/10.1073/pnas.1113890109DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3309789PMC
March 2012

Boundaries, junctions and transitions in the gastrointestinal tract.

Exp Cell Res 2011 Nov 23;317(19):2711-8. Epub 2011 Jul 23.

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.

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http://dx.doi.org/10.1016/j.yexcr.2011.07.011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3210370PMC
November 2011

Endodermal Hedgehog signals modulate Notch pathway activity in the developing digestive tract mesenchyme.

Development 2011 Aug;138(15):3225-33

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.

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http://dx.doi.org/10.1242/dev.066233DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3133914PMC
August 2011

Targeting PI3K signaling as a therapeutic approach for colorectal cancer.

Gastroenterology 2011 Jul;141(1):50-61

Department of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, and Department of Medicine, Brigham & Women's Hospital, Boston, MA 02215, USA.

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http://dx.doi.org/10.1053/j.gastro.2011.05.010DOI Listing
July 2011

Essential and redundant functions of caudal family proteins in activating adult intestinal genes.

Mol Cell Biol 2011 May 14;31(10):2026-39. Epub 2011 Mar 14.

Department of Medical Oncology, Dana-Farber Cancer Institute, 44 Binney Street, Boston, MA 02115, USA.

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http://mcb.asm.org/cgi/doi/10.1128/MCB.01250-10
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http://dx.doi.org/10.1128/MCB.01250-10DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3133364PMC
May 2011

Notch signaling in stomach epithelial stem cell homeostasis.

J Exp Med 2011 Apr 14;208(4):677-88. Epub 2011 Mar 14.

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.

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http://dx.doi.org/10.1084/jem.20101737DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3137787PMC
April 2011

Regulation of mouse stomach development and Barx1 expression by specific microRNAs.

Development 2011 Mar 9;138(6):1081-6. Epub 2011 Feb 9.

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215, USA.

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http://dev.biologists.org/cgi/doi/10.1242/dev.056317
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http://dx.doi.org/10.1242/dev.056317DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3042866PMC
March 2011

Genetic evidence that intestinal Notch functions vary regionally and operate through a common mechanism of Math1 repression.

J Biol Chem 2011 Apr 31;286(13):11427-33. Epub 2011 Jan 31.

Department of Medical Oncology, Dana-Farber Cancer Institute, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1074/jbc.M110.188797DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3064198PMC
April 2011

Gastric epithelial stem cells.

Gastroenterology 2011 Feb 7;140(2):412-24. Epub 2010 Dec 7.

Division of Gastroenterology, Department of Medicine, Pathology & Immunology, and Developmental Biology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.

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http://dx.doi.org/10.1053/j.gastro.2010.12.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3708552PMC
February 2011

Stem cells: The intestinal-crypt casino.

Nature 2010 Oct;467(7319):1055-6

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http://dx.doi.org/10.1038/4671055aDOI Listing
October 2010

Requirement of the epithelium-specific Ets transcription factor Spdef for mucous gland cell function in the gastric antrum.

J Biol Chem 2010 Nov 26;285(45):35047-55. Epub 2010 Aug 26.

Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1074/jbc.M110.164541DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2966119PMC
November 2010

Hedgehog signaling controls mesenchymal growth in the developing mammalian digestive tract.

Development 2010 May;137(10):1721-9

Department of Cancer Biology, University of Massachusetts Medical School, LRB 405, Worcester, MA 01605, USA.

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http://dx.doi.org/10.1242/dev.044586DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2860252PMC
May 2010

The microtubule modulator RanBP10 plays a critical role in regulation of platelet discoid shape and degranulation.

Blood 2009 Dec 2;114(27):5532-40. Epub 2009 Oct 2.

Labor für Pädiatrische Molekularbiologie der Klinik für Allgemeine Pädiatrie, Charité-Universitätsmedizin, Berlin, Germany.

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http://dx.doi.org/10.1182/blood-2009-04-216804DOI Listing
December 2009

Relationship of CDX2 loss with molecular features and prognosis in colorectal cancer.

Clin Cancer Res 2009 Jul 7;15(14):4665-73. Epub 2009 Jul 7.

Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1158/1078-0432.CCR-09-0401DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2777758PMC
July 2009

Trps1, a regulator of chondrocyte proliferation and differentiation, interacts with the activator form of Gli3.

Dev Biol 2009 Apr 14;328(1):40-53. Epub 2009 Jan 14.

Center for Medical Biotechnology, Department of Developmental Biology, University Duisburg-Essen, 45117 Essen, Germany.

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http://dx.doi.org/10.1016/j.ydbio.2009.01.012DOI Listing
April 2009

Wnt signaling in gut organogenesis.

Organogenesis 2008 Apr;4(2):87-91

Department of Medical Oncology; Dana-Farber Cancer Institute; and Department of Medicine; Harvard Medical School; Boston, Massachusetts, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2634253PMC
http://dx.doi.org/10.4161/org.4.2.5854DOI Listing
April 2008

Role of the homeodomain transcription factor Bapx1 in mouse distal stomach development.

Gastroenterology 2009 May 14;136(5):1701-10. Epub 2009 Jan 14.

Department of Medical Oncology, Dana-Farber Cancer Institute and Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1053/j.gastro.2009.01.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2955323PMC
May 2009

Cell-type selective chromatin remodeling defines the active subset of FOXA1-bound enhancers.

Genome Res 2009 Mar 7;19(3):372-80. Epub 2009 Jan 7.

Université de Rennes I, CNRS, UMR 6026, Equipe SPARTE, Campus de Beaulieu, 35042 Rennes cedex, France.

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http://dx.doi.org/10.1101/gr.084582.108DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2661808PMC
March 2009

Expression and function of Nkx6.3 in vertebrate hindbrain.

Brain Res 2008 Jul 6;1222:42-50. Epub 2008 May 6.

Department of Pediatric Oncology, Dana-Farber Cancer Institute, USA.

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http://dx.doi.org/10.1016/j.brainres.2008.04.072DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2555971PMC
July 2008

Transcription factor foxq1 controls mucin gene expression and granule content in mouse stomach surface mucous cells.

Gastroenterology 2008 Aug 22;135(2):591-600. Epub 2008 Apr 22.

Dana-Farber Cancer Institute and Department of Medicine, Boston, Massachusetts, USA.

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http://linkinghub.elsevier.com/retrieve/pii/S001650850800671
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http://dx.doi.org/10.1053/j.gastro.2008.04.019DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2955860PMC
August 2008

Culture, expansion, and differentiation of murine megakaryocytes.

Curr Protoc Immunol 2005 Jul;Chapter 22:Unit 22F.6

Dana-Farber Cancer Institute, Brigham and Women's Hospital, and Harvard Medical School, Boston, Massachusetts, USA.

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http://dx.doi.org/10.1002/0471142735.im22f06s67DOI Listing
July 2005

High-resolution analysis of genetic alterations in small bowel carcinoid tumors reveals areas of recurrent amplification and loss.

Genes Chromosomes Cancer 2008 Jul;47(7):591-603

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.

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http://dx.doi.org/10.1002/gcc.20561DOI Listing
July 2008

PU.1 is a major downstream target of AML1 (RUNX1) in adult mouse hematopoiesis.

Nat Genet 2008 Jan 11;40(1):51-60. Epub 2007 Nov 11.

Hematology/Oncology Division, Harvard Institutes of Medicine, 77 Avenue Louis Pasteur, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1038/ng.2007.7DOI Listing
January 2008

Dynamic visualization of thrombopoiesis within bone marrow.

Science 2007 Sep;317(5845):1767-70

Immune Disease Institute and Department of Pathology, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1126/science.1146304DOI Listing
September 2007

Independent functions and mechanisms for homeobox gene Barx1 in patterning mouse stomach and spleen.

Development 2007 Oct 12;134(20):3603-13. Epub 2007 Sep 12.

Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA.

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http://dx.doi.org/10.1242/dev.009308DOI Listing
October 2007

Phases of canonical Wnt signaling during the development of mouse intestinal epithelium.

Gastroenterology 2007 Aug 3;133(2):529-38. Epub 2007 May 3.

Dana-Farber Cancer Institute and Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA.

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http://dx.doi.org/10.1053/j.gastro.2007.04.072DOI Listing
August 2007

Expression analysis of primary mouse megakaryocyte differentiation and its application in identifying stage-specific molecular markers and a novel transcriptional target of NF-E2.

Blood 2007 Feb 17;109(4):1451-9. Epub 2006 Oct 17.

Dana-Farber Cancer Institute, Department of Medicine, Harvard Medical School, Brigham & Women's Hospital, Boston, MA 02115, USA.

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http://dx.doi.org/10.1182/blood-2006-08-038901DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1794061PMC
February 2007