Ramaswamy Govindan

Ramaswamy Govindan

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Ramaswamy Govindan

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Untangling the evolutionary roots of lung cancer.

Nat Commun 2019 Jul 5;10(1):2979. Epub 2019 Jul 5.

Division of Oncology, Washington University School of Medicine in St. Louis, St. Louis, MO, 63110, United States.

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http://dx.doi.org/10.1038/s41467-019-10879-6DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6611778PMC
July 2019

Targeting Resistance to Targeted Therapies: Combating a Resilient Foe.

Clin Cancer Res 2018 12 23;24(24):6112-6114. Epub 2018 Oct 23.

Division of Oncology, Washington University School of Medicine, St. Louis, Missouri.

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http://dx.doi.org/10.1158/1078-0432.CCR-18-3178DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6295273PMC
December 2018

Tumor Mutation Burden as a Biomarker in Resected Non-Small-Cell Lung Cancer.

J Clin Oncol 2018 10 14;36(30):2995-3006. Epub 2018 Aug 14.

Siddhartha Devarakonda, Irena Lanc, and Ramaswamy Govindan, Washington University School of Medicine; Siddhartha Devarakonda and Ramaswamy Govindan, Siteman Cancer Center; Robert Fulton, Washington University School of Medicine, St. Louis; Ashiq Masood, University of Missouri Kansas City, Kansas City, MO; Federico Rotolo, Ken A. Olaussen, Gwénaël Le Teuff, Jean-Pierre Pignon, and Stefan Michiels, Université Paris-Saclay; Federico Rotolo, Ken A. Olaussen, Gwénaël Le Teuff, Jean-Pierre Pignon, Jean-Charles Soria, and Stefan Michiels, Gustave Roussy Cancer Campus, Villejuif; Elisabeth Brambilla and Anne McLeer-Florin, Centre Hospitalier Universitaire de Grenoble, La Tronche, France; Ming-Sound Tsao, Shingo Sakashita, and Frances A. Shepherd, Princess Margaret Cancer Centre and University of Toronto, Toronto; Keyue Ding and Lesley Seymour, Queen's University Kingston, Ontario, Canada; Stephen L. Graziano, State University of New York Upstate Medical University, Syracuse, NY; Robert Kratzke, University of Minnesota Medical School, Minneapolis, MN.

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http://dx.doi.org/10.1200/JCO.2018.78.1963DOI Listing
October 2018

Phase Ib/II study of the pan-cyclin-dependent kinase inhibitor roniciclib in combination with chemotherapy in patients with extensive-disease small-cell lung cancer.

Lung Cancer 2018 09 27;123:14-21. Epub 2018 Apr 27.

Aix Marseille University, Jardin du Pharo, 58, bd Charles Livon, 13284 Marseille, France; Assistance Publique Hôpitaux de Marseille, 80, rue Brochier, 13005 Marseille, France; Centre d'Essais Précoces en Cancérologie de Marseille (CLIP(2)), Hôpital La Timone - Basement F, 1st Floor, 264, rue St Pierre, 13885 Marseille, France. Electronic address:

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http://dx.doi.org/10.1016/j.lungcan.2018.04.022DOI Listing
September 2018

The Impact of Staging by Positron-Emission Tomography on Overall Survival and Progression-Free Survival in Patients With Locally Advanced NSCLC.

J Thorac Oncol 2018 08 5;13(8):1183-1188. Epub 2018 May 5.

Department of Radiation Oncology, VU University Medical Center, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1016/j.jtho.2018.04.028DOI Listing
August 2018

Non-small-cell Lung Cancer With Brain Metastasis at Presentation.

Clin Lung Cancer 2018 07 9;19(4):e373-e379. Epub 2018 Mar 9.

Division of Medical Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO. Electronic address:

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http://dx.doi.org/10.1016/j.cllc.2018.01.007DOI Listing
July 2018

Early Mortality in Patients Undergoing Adjuvant Chemotherapy for Non-Small Cell Lung Cancer.

J Thorac Oncol 2018 04 2;13(4):543-549. Epub 2018 Feb 2.

Division of Cardiothoracic Surgery, Department of Surgery, Washington University in St. Louis, St. Louis, Missouri.

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https://linkinghub.elsevier.com/retrieve/pii/S15560864183003
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http://dx.doi.org/10.1016/j.jtho.2018.01.010DOI Listing
April 2018

Phase III Trial of Ipilimumab Combined With Paclitaxel and Carboplatin in Advanced Squamous Non-Small-Cell Lung Cancer.

J Clin Oncol 2017 Oct 30;35(30):3449-3457. Epub 2017 Aug 30.

Ramaswamy Govindan, Washington University School of Medicine, St Louis, MO; Aleksandra Szczesna, Mazowieckie Centrum Leczenia Chorób Płuc i Gruźlicy, Otwock; Jacek Jassem, Medical University of Gdansk, Gdansk, Poland; Myung-Ju Ahn, Samsung Medical Center, Sungkyunkwan University, Seoul; Ki Hyeong Lee, Chungbuk National University Hospital, Cheongju-si, Republic of Korea; Claus-Peter Schneider, Zentralklinik Bad Berka, Bad Berka; Joachim Von Pawel, Asklepius Fachkliniken, Gauting; Martin Reck, LungenClinic Grosshansdorf, Airway Research Center North, German Center for Lung Research, Grosshansdorf, Germany; Pablo Fernando Gonzalez Mella, Centro de Investigaciones Clinicas, Universidad de Valparaíso and Fundación Arturo López Pérez, Santiago, Chile; Fabrice Barlesi, Aix Marseille University, Assistance Publique-Hôpitaux de Marseille, Marseille, France; Baohui Han, Shanghai Chest Hospital Affiliated to Shanghai JiaoTong University, Shanghai; Li Zhang, Sun Yat-Sen University Cancer Center, Guangzhou, People's Republic of China; Doina Elena Ganea, Spitalul Judetean De Urgenta Suceava, Sfântul loan cel Nou, Suceava, Romania; Vladimir Vladimirov, State Healthcare Institute, Pyatigorsk Oncology Dispensary, Pyatigorsk; Natalia Fadeeva, Chelyabinsk Regional Oncology Dispensary, Chelyabinsk, Russian Federation; Takayasu Kurata, Kansai Medical University Hirakata Hospital, Osaka; Tomohide Tamura, St Luke's International Hospital, Tokyo, Japan; Pieter E. Postmus, University of Liverpool, Liverpool, United Kingdom; Kenneth O'Byrne, Princess Alexandra Hospital and Queensland University of Technology, Brisbane, Queensland, Australia; and Justin Kopit, Mingshun Li, and Marina Tschaika, Bristol-Myers Squibb, Princeton, NJ.

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http://ascopubs.org/doi/10.1200/JCO.2016.71.7629
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http://dx.doi.org/10.1200/JCO.2016.71.7629DOI Listing
October 2017

Pooled Analysis of Individual Patient Data on Concurrent Chemoradiotherapy for Stage III Non-Small-Cell Lung Cancer in Elderly Patients Compared With Younger Patients Who Participated in US National Cancer Institute Cooperative Group Studies.

J Clin Oncol 2017 Sep 11;35(25):2885-2892. Epub 2017 May 11.

Thomas E. Stinchcombe, Neal E. Ready, and Harvey J. Cohen, Duke University Medical Center; Xiaofei Wang, Alliance Statistics and Data Center, Durham, NC; Ying Zhang, Pennsylvania State University College of Medicine, Hershey, PA; Everett E. Vokes, University of Chicago Medical Center, Chicago, IL; Joan H. Schiller, Inova Dwight and Martha Schar Cancer Institute, Falls Church, VA; Jeffrey D. Bradley and Ramaswamy Govindan, Washington University School of Medicine, St Louis, MO; Karen Kelly, University of California Davis, Sacramento, CA; Walter J. Curran Jr, Winship Cancer Institute of Emory University, Atlanta, GA; Steven E. Schild, Mayo Clinic Arizona, Scottsdale, AZ; Benjamin Movsas, Henry Ford Health System, Detroit, MI; Gerald Clamon, University of Iowa Hospital and Clinics, Iowa City, IA; George R. Blumenschein, University of Texas MD Anderson Cancer Center, Houston, TX; Mark A. Socinski, Florida Hospital Cancer Institute, Orlando, FL; Wallace L. Akerley, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT; and Herbert H. Pang, University of Hong Kong, Hong Kong Special Administrative Region, People's Republic of China.

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http://dx.doi.org/10.1200/JCO.2016.71.4758DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5578390PMC
September 2017

Next-Generation Sequencing of Lung Cancers: Lessons Learned and Future Directions.

Hematol Oncol Clin North Am 2017 02;31(1):1-12

Section of Medical Oncology, Division of Oncology, Alvin J Siteman Cancer Center, Washington University School of Medicine, 660 South Euclid Avenue, Box 8056, St. Louis, MO 63110, USA. Electronic address:

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http://dx.doi.org/10.1016/j.hoc.2016.08.008DOI Listing
February 2017

Systemic Treatment of Brain Metastases.

Hematol Oncol Clin North Am 2017 02;31(1):157-176

Section of Medical Oncology, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8056, St Louis, MO 63110, USA.

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http://dx.doi.org/10.1016/j.hoc.2016.08.007DOI Listing
February 2017

Phase I Results from a Study of Crizotinib in Combination with Erlotinib in Patients with Advanced Nonsquamous Non-Small Cell Lung Cancer.

J Thorac Oncol 2017 01 30;12(1):145-151. Epub 2016 Sep 30.

Birmingham Veterans Administration Hospital, Birmingham, Alabama; University of Alabama-Birmingham Comprehensive Cancer Center, Birmingham, Alabama.

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http://dx.doi.org/10.1016/j.jtho.2016.09.131DOI Listing
January 2017

Pooled Analysis of CNS Response to Alectinib in Two Studies of Pretreated Patients With ALK-Positive Non-Small-Cell Lung Cancer.

J Clin Oncol 2016 12 31;34(34):4079-4085. Epub 2016 Oct 31.

Shirish M. Gadgeel, Karmanos Cancer Institute, Wayne State University, Detroit, MI; Alice T. Shaw, Massachusetts General Hospital; Leena Gandhi, Dana-Farber Cancer Institute, Boston, MA; Ramaswamy Govindan, Washington University School of Medicine, St Louis, MO; Mark A. Socinski, University of Pittsburgh, Pittsburgh, PA; D. Ross Camidge, University of Colorado Cancer Center, Denver, CO; Alberto Chiappori, Thoracic Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL; Sai-Hong Ignatius Ou, University of California at Irvine, Orange, CA; Luigi De Petris, Karolinska Institutet, Stockholm, Sweden; Dong-Wan Kim, Seoul National University Hospital, Seoul; Ji-Youn Han, Lung Cancer Centre, National Cancer Centre, Goyang, South Korea; Denis L. Moro-Sibilot, Service de Pneumologie; Michael Duruisseaux, Centre Hospitalier Universitaire de Grenoble, Grenoble; Eric Dansin, Centre Oscar Lambret, Lille, France; Lucio Crino, Santa Maria della Misericordia Hospital, Perugia; Tommaso De Pas, European Institute of Oncology, Milan, Italy; Antje Tessmer, Evangelische Lungenklinik Berlin, Berlin, Germany; James Chih-Hsin Yang, Graduate Institute of Oncology and Cancer Research Centre, National Taiwan University, Taipei, Taiwan; and Walter Bordogna, Sophie Golding, and Ali Zeaiter, F. Hoffmann-La Roche, Basel, Switzerland.

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http://dx.doi.org/10.1200/JCO.2016.68.4639DOI Listing
December 2016

NCCN Guidelines Insights: Malignant Pleural Mesothelioma, Version 3.2016.

J Natl Compr Canc Netw 2016 07;14(7):825-36

From The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; Fred Hutchinson Cancer Research Center/Seattle Cancer Care Alliance; Huntsman Cancer Institute at the University of Utah; UC San Diego Moores Cancer Center; Fox Chase Cancer Center; University of Colorado Cancer Center; Roswell Park Cancer Institute; Dana-Farber/Brigham and Women's Cancer Center; Duke Cancer Institute; Moffitt Cancer Center; University of Alabama at Birmingham Comprehensive Cancer Center; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; Vanderbilt-Ingram Cancer Center; UCSF Helen Diller Family Comprehensive Cancer Center; The University of Texas MD Anderson Cancer Center; Fred & Pamela Buffett Cancer Center; Massachusetts General Hospital Cancer Center; Yale Cancer Center/Smilow Cancer Hospital; University of Michigan Comprehensive Cancer Center; Stanford Cancer Institute; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; City of Hope Comprehensive Cancer Center; Memorial Sloan Kettering Cancer Center; Mayo Clinic Cancer Center; Case Comprehensive Cancer Center/University Hospitals Seidman Cancer Center and Cleveland Clinic Taussig Cancer Institute; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; and National Comprehensive Cancer Network.

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July 2016

Delayed nausea and vomiting from carboplatin doublet chemotherapy.

Acta Oncol 2016 Jun 4;55(6):700-4. Epub 2016 May 4.

a Division of Oncology, Department of Internal Medicine , Washington University School of Medicine , St. Louis , Missouri , USA ;

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http://dx.doi.org/10.3109/0284186X.2016.1154603DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4985438PMC
June 2016

Clinical Implications of Genomic Discoveries in Lung Cancer.

N Engl J Med 2016 May;374(19):1864-73

From the Translational Cancer Therapeutics Laboratory, Francis Crick Institute, and the Cancer Research UK (CRUK) Lung Cancer Centre of Excellence, University College London Hospitals and Cancer Institute, London (C.S.); and the Division of Oncology, Department of Medicine, and the Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis (R.G.).

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http://dx.doi.org/10.1056/NEJMra1504688DOI Listing
May 2016

Genomic landscape of squamous cell carcinoma of the lung.

Am Soc Clin Oncol Educ Book 2013 :348-53

From the Division of Oncology, Department of Medicine, Yale University, New Haven, CT; Department of Internal Medicine, St. Luke's Hospital, Chesterfield, MO; Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, MO; Alvin J Siteman Cancer Center at Washington University School of Medicine, St. Louis, MO.

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http://dx.doi.org/10.1200/EdBook_AM.2013.33.348DOI Listing
April 2016

Alectinib in Crizotinib-Refractory ALK-Rearranged Non-Small-Cell Lung Cancer: A Phase II Global Study.

J Clin Oncol 2016 Mar 23;34(7):661-8. Epub 2015 Nov 23.

Sai-Hong Ignatius Ou, University of California Irvine School of Medicine, Orange, CA; Jin Seok Ahn, Sungkyunkwan University School of Medicine; Luigi De Petris, Karolinska Institute and Karolinska University Hospital, Stockholm, Sweden; Ramaswamy Govindan, Washington University School of Medicine, St Louis, MO; James Chih-Hsin Yang, National Taiwan University, Taipei, Taiwan; Brett Hughes, The Prince Charles Hospital, Chermside, and University of Queensland, Queensland, Australia; Hervé Lena, Centre Hospitalier Universitaire de Rennes, Rennes; Denis Moro-Sibilot, Centre Hospitalier Universitaire de Grenoble, Institut National de la Santé et de la Recherche Médicale U823, Grenoble, France; Alessandra Bearz, National Cancer Institute, Aviano, Italy; Santiago Viteri Ramirez, Quiron-Dexeus University Hospital, Barcelona, Spain; Tarek Mekhail, Florida Hospital Cancer Institute, Orlando, FL; Alexander Spira, Virginia Cancer Specialists, Fairfax, VA; and Walter Bordogna, Bogdana Balas, Peter N. Morcos, Annabelle Monnet, and Ali Zeaiter, F. Hoffmann-La Roche, Basel, Switzerland; Dong-Wan Kim, Seoul National University Hospital, Seoul, South Korea.

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http://dx.doi.org/10.1200/jco.2016.34.4_suppl.661DOI Listing
March 2016

PROCLAIM: Randomized Phase III Trial of Pemetrexed-Cisplatin or Etoposide-Cisplatin Plus Thoracic Radiation Therapy Followed by Consolidation Chemotherapy in Locally Advanced Nonsquamous Non-Small-Cell Lung Cancer.

J Clin Oncol 2016 Mar 25;34(9):953-62. Epub 2016 Jan 25.

Suresh Senan, VU Medical Center, Amsterdam; Bonne Biesma, Jeroen Bosch Hospital, 's-Hertogenbosch; and Joachim Aerts, Erasmus MC Rotterdam/Amphia Hospital Breda, Breda, the Netherlands; Anthony Brade, Princess Margaret Hospital, University of Toronto; Neill Iscoe, Eli Lilly Canada, Toronto, Ontario, Canada; Lu-hua Wang, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing; Tony Mok, The Chinese University of Hong Kong, Shatin, Hong Kong Special Administrative Region, People's Republic of China; Johan Vansteenkiste, University Hospital KU Leuven, Leuven, Belgium; Shaker Dakhil, Cancer Center of Kansas, Wichita, KS; Ramaswamy Govindan, Washington University School of Medicine, Saint Louis, MO; David Gandara, University of California, Davis Health System, Sacramento, CA; Hak Choy, UT Southwestern Medical Center, Dallas, TX; Anwar Hossain, Joseph Treat, and Andrew Koustenis, Eli Lilly and Company, Indianapolis, IN; Everett Vokes, University of Chicago, Chicago, IL; Maite Martinez Aguillo, Hospital of Navarre, Irunlarrea, Pamplona; Belén Rubio-Viqueira, Hospital Universitario Quirón Madrid; and Bélen San Antonio, Eli Lilly and Company, Madrid, Spain; Conrad Lewanski, Charing Cross Hospital, London, United Kingdom; and Nadia Chouaki, Eli Lilly and Company, Neuilly-sur-Seine, France.

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http://dx.doi.org/10.1200/JCO.2015.64.8824DOI Listing
March 2016

Bone metastases in lung cancer. Potential novel approaches to therapy.

Am J Respir Crit Care Med 2015 Oct;192(7):799-809

1 Division of Oncology, Center for Applied Medical Research, and.

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http://www.atsjournals.org/doi/10.1164/rccm.201503-0440SO
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http://dx.doi.org/10.1164/rccm.201503-0440SODOI Listing
October 2015

Clonal evolution: multiregion sequencing of esophageal adenocarcinoma before and after chemotherapy.

Cancer Discov 2015 Aug;5(8):796-8

Division of Medical Oncology, Washington University School of Medicine, St. Louis, Missouri. Alvin J. Siteman Cancer Center, St. Louis, Missouri.

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http://dx.doi.org/10.1158/2159-8290.CD-15-0739DOI Listing
August 2015

Genomic alterations in lung adenocarcinoma.

Lancet Oncol 2015 Jul;16(7):e342-51

Division of Medical Oncology, Washington University School of Medicine, St Louis, MO, USA; Alvin J Siteman Cancer Center, St Louis, MO, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S14702045150007
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http://dx.doi.org/10.1016/S1470-2045(15)00077-7DOI Listing
July 2015

Definitive and Adjuvant Radiotherapy in Locally Advanced Non-Small-Cell Lung Cancer: American Society of Clinical Oncology Clinical Practice Guideline Endorsement of the American Society for Radiation Oncology Evidence-Based Clinical Practice Guideline.

J Clin Oncol 2015 Jun 5;33(18):2100-5. Epub 2015 May 5.

Andrea Bezjak, Princess Margaret Cancer Center, Toronto, Ontario, Canada; Sarah Temin, American Society of Clinical Oncology, Alexandria, VA; Gregg Franklin, New Mexico Cancer Center, Albuquerque, NM; Giuseppe Giaccone, Lombardi Cancer Center, Washington, DC; Ramaswamy Govindan, Washington University, St Louis, MO; Melissa L. Johnson, Lurie Comprehensive Cancer Center, Northwestern University, Chicago, IL; Andreas Rimner, Memorial Sloan Kettering Cancer Center; Bryan J. Schneider, Weill Cornell Medical College, New York, NY; John Strawn, Patient Representative, Houston, TX; and Christopher G. Azzoli, Massachusetts General, Boston, MA.

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http://ascopubs.org/doi/10.1200/JCO.2014.59.2360
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http://dx.doi.org/10.1200/JCO.2014.59.2360DOI Listing
June 2015

Non-Small Cell Lung Cancer, Version 6.2015.

J Natl Compr Canc Netw 2015 May;13(5):515-24

The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; University of Washington/Seattle Cancer Care Alliance; Huntsman Cancer Institute at the University of Utah; UC San Diego Moores Cancer Center; Fox Chase Cancer Center; University of Colorado Cancer Center; Roswell Park Cancer Institute; Dana-Farber/Brigham and Women's Cancer Center; Duke Cancer Institute; Moffitt Cancer Center; University of Alabama at Birmingham Comprehensive Cancer Center; Siteman Cancer Center at Barnes-Jewish Hospital and Washington University School of Medicine; City of Hope Comprehensive Cancer Center; Vanderbilt-Ingram Cancer Center; UCSF Helen Diller Family Comprehensive Cancer Center; The University of Texas MD Anderson Cancer Center; Memorial Sloan Kettering Cancer Center; Fred & Pamela Buffett Cancer Center; Massachusetts General Hospital Cancer Center; Yale Cancer Center/Smilow Cancer Hospital; University of Michigan Comprehensive Cancer Center; Stanford Cancer Institute; Fred Hutchinson Cancer Research Center/Seattle Cancer Care Alliance; The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute; Robert H. Lurie Comprehensive Cancer Center of Northwestern University; Mayo Clinic Cancer Center; St. Jude Children's Research Hospital/The University of Tennessee Health Science Center; and National Comprehensive Cancer Network.

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May 2015

New insights into the molecular profile of lung adenocarcinoma and implications for therapy.

Expert Rev Anticancer Ther 2015 Apr 8;15(4):361-4. Epub 2015 Mar 8.

1 Division of Medical Oncology, Washington University School of Medicine in St. Louis, 660 S. Euclid, Box 8056, St. Louis, MO 63021, USA.

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http://www.tandfonline.com/doi/full/10.1586/14737140.2015.10
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http://dx.doi.org/10.1586/14737140.2015.1017472DOI Listing
April 2015

Overcoming resistance to targeted therapy for lung cancer.

N Engl J Med 2015 Apr;372(18):1760-1

From the Department of Medicine and the Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis.

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http://dx.doi.org/10.1056/NEJMe1500181DOI Listing
April 2015

Epidermal growth factor receptor tyrosine kinase inhibitors in non-small cell lung cancer: a decade of progress and hopeful future.

J Thorac Dis 2015 Mar;7(3):217-9

1 Department of Medicine, Cooper Medical School of Rowan University, Camden, NJ 08103, USA ; 2 Division of Oncology, Washington University School of Medicine, St. Louis, MO 63021, USA ; 3 Alvin J. Siteman Cancer Center, St. Louis, MO, USA.

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http://dx.doi.org/10.3978/j.issn.2072-1439.2015.01.53DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4387445PMC
March 2015

Quality of life analyses from the randomized, open-label, phase III PointBreak study of pemetrexed-carboplatin-bevacizumab followed by maintenance pemetrexed-bevacizumab versus paclitaxel-carboplatin-bevacizumab followed by maintenance bevacizumab in patients with stage IIIB or IV nonsquamous non-small-cell lung cancer.

J Thorac Oncol 2015 Feb;10(2):353-9

*Sarah Cannon Research Institute/Tennessee Oncology, PLLC, Nashville, TN; †Feinberg School of Medicine, Northwestern University, Chicago, IL; ‡Ocala Oncology, Ocala, FL and US Oncology Research, Inc., Houston, TX; §David Geffen School of Medicine at UCLA/Translational Research in Oncology-US, Los Angeles, CA; ║Northwest Georgia Oncology Centers, Marietta, GA; ¶Washington University School of Medicine, St. Louis, MO; #Tulsa Cancer Institute, Tulsa, OK; **Eli Lilly and Company, Indianapolis, IN; ††University of Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, PA; and ‡‡Rush University Medical Center, Chicago, IL.

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http://dx.doi.org/10.1097/JTO.0000000000000277DOI Listing
February 2015

PRONOUNCE: randomized, open-label, phase III study of first-line pemetrexed + carboplatin followed by maintenance pemetrexed versus paclitaxel + carboplatin + bevacizumab followed by maintenance bevacizumab in patients ith advanced nonsquamous non-small-cell lung cancer.

J Thorac Oncol 2015 Jan;10(1):134-42

*Department of Investigational Cancer therapeutics, University of Texas M. D. Anderson Cancer Center, Houston, Texas; †Global Diversity/Med Affairs, Eli Lilly and Company, Indianapolis, Indiana; ‡Medical Oncology, Tennessee Oncology, Nashville, Tennessee; §Hematology/Oncology, Florida Cancer Specialists, Fort Myers, Florida; •Medical Oncology, Highlands Oncology Group, Fayetteville, Arkansas; ¶Hematology-Medical Oncology, Oncology Heamatology Care Inc., Blue Ash, Ohio; #Hematology & Oncology, Internal Medicine, ACRC/Arizona Clinical Research Center, Arizona Oncology, Tucson, Arizona; **Hematology and Oncology, Michigan State University, East Lansing, Michigan; ††Northeast Georgia Cancer Care, University of Georgia Health Sciences University, Athens, Georgia; ‡‡Statistics Oncology, §§CDK4/6 Product Team, GPORWE-Oncology, ¶¶Oncology-Global Strategic Plan, ##Oncology-Early Phase, ***US Med Affairs and Late Phase Prod Dev, †††Global Medical Communications-Oncology, and ‡‡‡Global Med Affairs & Late Phase Prod Dev, Eli Lilly and Company, Indianapolis, Indiana; §§§Department of Medicine, Oncology Division, Washington University Medical School, St. Louis, Missouri; and ••Hematology/Oncology, Mayo Clinic Arizona, Scottsdale, Arizona.

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http://dx.doi.org/10.1097/JTO.0000000000000366DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4276572PMC
January 2015

Molecularly targeted therapies in non-small-cell lung cancer annual update 2014.

J Thorac Oncol 2015 Jan;10(1 Suppl 1):S1-63

*Department of Medical Oncology, Washington University School of Medicine, Saint Louis, Missouri; Departments of †Medical Oncology and ‡Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, Massachusetts; §Department of Medical Oncology, University of Colorado School of Medicine and University of Colorado Cancer Center, Aurora, Colorado; ‖UCLA Santa Monica Hematology Oncology, Santa Monica, California; ¶Division of Hematology-Oncology, Harold C. Simmons Cancer Center, University of Texas Southwestern Medical Center, Dallas, Texas; #Department of Medical Oncology, Yale School of Medicine and Cancer Center, New Haven, Connecticut; **Massachusetts General Hospital Cancer Center, Boston, Massachusetts; ††Department of Oncology, The University of Chicago Medicine, Chicago, Illinois; ‡‡Division of Hematology-Oncology, Vanderbilt University Medical Center, Nashville, Tennessee; §§Department of Hematology and Medical Oncology, Emory University School of Medicine, Winship Cancer Institute, Atlanta, Georgia; ‖‖Memorial Sloan-Kettering Cancer Center, New York, New York; ¶¶Division of Hematology-Oncology, Medical University of South Carolina, Charleston, South Carolina; ##Sarah Cannon Research Institute, Nashville, Tennessee; ***The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, Maryland; †††Department of Internal Medicine, UT Southwestern Medical Center, Dallas, Texas; and ‡‡‡Division of Medical Oncology, University of Colorado Denver School of Medicine, Denver, Colorado.

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http://dx.doi.org/10.1097/JTO.0000000000000405DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346098PMC
January 2015

CHESS improves cancer caregivers' burden and mood: results of an eHealth RCT.

Health Psychol 2014 Oct 18;33(10):1261-72. Epub 2013 Nov 18.

Hematology-Oncology Unit of the Department of Medicine, School of Medicine and Public Health, University of Wisconsin.

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http://dx.doi.org/10.1037/a0034216DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4121384PMC
October 2014

Cancer. Attack of the clones.

Science 2014 Oct;346(6206):169-70

Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA. Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1126/science.1259926DOI Listing
October 2014

TP53 mutations and lung cancer: not all mutations are created equal.

Clin Cancer Res 2014 Sep 10;20(17):4419-21. Epub 2014 Jun 10.

Department of Medicine and Alvin J Siteman Cancer Center, Washington University School of Medicine, St. Louis, Missouri.

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http://dx.doi.org/10.1158/1078-0432.CCR-14-0899DOI Listing
September 2014

The oligometastatic state - separating truth from wishful thinking.

Nat Rev Clin Oncol 2014 09 24;11(9):549-57. Epub 2014 Jun 24.

University of Chicago Medical Center, 5841 South Maryland Avenue, Chicago, IL 60637, USA.

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http://dx.doi.org/10.1038/nrclinonc.2014.96DOI Listing
September 2014

cDNA hybrid capture improves transcriptome analysis on low-input and archived samples.

J Mol Diagn 2014 Jul 9;16(4):440-51. Epub 2014 May 9.

The Genome Institute, Washington University School of Medicine, St. Louis, Missouri; Division of Oncology, Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri; Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, Missouri; Department of Biomedical Engineering, Washington University School of Medicine, St. Louis, Missouri. Electronic address:

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http://dx.doi.org/10.1016/j.jmoldx.2014.03.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4078367PMC
July 2014

A phase I study of temsirolimus and thoracic radiation in non--small-cell lung cancer.

Clin Lung Cancer 2014 Mar 15;15(2):119-23. Epub 2013 Nov 15.

Division of Medical Oncology, Department of Internal Medicine, Washington University School of Medicine, St Louis, MO. Electronic address:

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http://dx.doi.org/10.1016/j.cllc.2013.11.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4002355PMC
March 2014

A phase I trial of sunitinib and rapamycin in patients with advanced non-small cell lung cancer.

Chemotherapy 2013 26;59(1):8-13. Epub 2013 Apr 26.

Division of Medical Oncology, Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.

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http://dx.doi.org/10.1159/000348584DOI Listing
February 2014

Stabilization of disease after targeted therapy in a thymic carcinoma with KIT mutation detected by clinical next-generation sequencing.

J Thorac Oncol 2014 Feb;9(2):e12-6

*Genomics and Pathology Services, Department of Pathology and Immunology, †Section of Medical Oncology, Department of Medicine, and ‡Mallinckrodt Institute of Radiology, Washington University, St. Louis, Missouri.

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http://dx.doi.org/10.1097/JTO.0b013e3182a7d22eDOI Listing
February 2014

Summary report from the 13(th) Annual Targeted Therapies of the Treatment of Lung Cancer Meeting.

Clin Lung Cancer 2014 Jan 20;15(1):16-20. Epub 2013 Nov 20.

Division of Medical Oncology, Washington University School of Medicine, St. Louis, MO; Alvin J. Siteman Cancer Center, St. Louis, MO.

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https://linkinghub.elsevier.com/retrieve/pii/S15257304130023
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http://dx.doi.org/10.1016/j.cllc.2013.11.010DOI Listing
January 2014

DGIdb: mining the druggable genome.

Nat Methods 2013 Dec 13;10(12):1209-10. Epub 2013 Oct 13.

1] The Genome Institute, Washington University School of Medicine, St. Louis, Missouri, USA. [2] Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, USA. [3].

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http://dx.doi.org/10.1038/nmeth.2689DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3851581PMC
December 2013

PointBreak: a randomized phase III study of pemetrexed plus carboplatin and bevacizumab followed by maintenance pemetrexed and bevacizumab versus paclitaxel plus carboplatin and bevacizumab followed by maintenance bevacizumab in patients with stage IIIB or IV nonsquamous non-small-cell lung cancer.

J Clin Oncol 2013 Dec 21;31(34):4349-57. Epub 2013 Oct 21.

Jyoti D. Patel, Northwestern University; Philip Bonomi, Rush University Medical Center, Chicago, IL; Mark A. Socinski, University of Pittsburgh, Pittsburgh, PA; Edward B. Garon, University of California at Los Angeles, Los Angeles, CA; Craig H. Reynolds, US Oncology Research, Ocala, FL; David R. Spigel, Sarah Cannon Research Institute-Tennessee Oncology, Nashville, TN; Mark R. Olsen, Tulsa Cancer Institute, Tulsa, OK; Robert C. Hermann, Northwest Georgia Oncology Centers, Marietta, GA; Robert M. Jotte, Rocky Mountain Cancer Centers, Denver, CO; Thaddeus Beck, Highlands Oncology Group, Fayetteville, AR; Donald A. Richards, US Oncology Research, Tyler, TX; Susan C. Guba, Jingyi Liu, Bente Frimodt-Moller, and William J. John, Eli Lilly, Indianapolis, IN; Coleman K. Obasaju and Eduardo J. Pennella, Lilly USA, Indianapolis, IN; and Ramaswamy Govindan, Washington University School of Medicine, St. Louis, MO.

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http://dx.doi.org/10.1200/JCO.2012.47.9626DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4881367PMC
December 2013

In response.

J Thorac Oncol 2013 Dec;8(12):e116-7

Department of Medicine, Division of Oncology, Washington University School of Medicine, St Louis, MO.

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http://dx.doi.org/10.1097/JTO.0000000000000010DOI Listing
December 2013

Randomized phase II trial of Onartuzumab in combination with erlotinib in patients with advanced non-small-cell lung cancer.

J Clin Oncol 2013 Nov 7;31(32):4105-14. Epub 2013 Oct 7.

David R. Spigel, Thomas J. Ervin, and Davey B. Daniel, Sarah Cannon Research Institute; David R. Spigel, Tennessee Oncology, Nashville; Davey B. Daniel, Chattanooga Oncology Hematology Associates, Chattanooga, TN; Thomas J. Ervin, Florida Cancer Specialists, Fort Myers; Michael S. Wertheim, Hematology/Oncology Associates, Port St Lucie, FL; Rodryg A. Ramlau, Poznan University of Medical Sciences, Poznan; Maciej J. Krzakowski, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland; Jerome H. Goldschmidt Jr, Blue Ridge Cancer Care, Christianburg, VA; George R. Blumenschein Jr, The University of Texas MD Anderson Cancer Center, Houston, TX; Gilles Robinet, University Hospital Morvan, Brest; Benoit Godbert, Centre Hospitalier Universitaire Nancy, Vandoeuvre-lès-Nancy; Fabrice Barlesi, Assistance Publique-Hôpitaux de Marseille, Aix Marseille University, Marseille, France; Ramaswamy Govindan, Washington University School of Medicine, St Louis, MO; Taral Patel, Mid Ohio Oncology/Hematology, Columbus, OH; Sergey V. Orlov, St Petersburg Pavlov State Medical University, St Petersburg, Russia; Wei Yu, Robert L. Yauch, Premal H. Patel, and See-Chun Phan, Genentech; Amy C. Peterson, Medivation, San Francisco, CA; and Jiping Zha, Crown Bioscience, Taicang City, China.

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http://jco.ascopubs.org/cgi/doi/10.1200/JCO.2012.47.4189
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http://dx.doi.org/10.1200/JCO.2012.47.4189DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4878106PMC
November 2013

Phase 2 study of pemetrexed plus carboplatin, or pemetrexed plus cisplatin with concurrent radiation therapy followed by pemetrexed consolidation in patients with favorable-prognosis inoperable stage IIIA/B non-small-cell lung cancer.

J Thorac Oncol 2013 Oct;8(10):1308-16

*University of Texas Southwestern, Dallas, Texas; †ACORN and West Clinic, Memphis, Tennessee; ‡Cancer Center of Kansas, Wichita, Kansas; §UCLA/Translational Oncology Research International Network, Los Angeles, Los Angeles; ‖Alamance Regional Medical Center, Burlington, North Carolina; ¶Washington University, St. Louis, Missouri; and #Lilly USA, LLC, Indianapolis, Indiana.

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http://dx.doi.org/10.1097/JTO.0b013e3182a02546DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4715866PMC
October 2013

An emerging place for lung cancer genomics in 2013.

J Thorac Dis 2013 Oct;5 Suppl 5:S491-7

The University of Queensland and the Prince Charles Hospital Thoracic Research Centre, the Prince Charles Hospital, Chermside 4032, Australia;

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http://dx.doi.org/10.3978/j.issn.2072-1439.2013.10.06DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3804884PMC
October 2013

Molecularly targeted therapies in locally advanced non-small-cell lung cancer.

Clin Lung Cancer 2013 Sep 14;14(5):467-72. Epub 2013 May 14.

Department of Internal Medicine, St. Luke's Hospital, Chesterfield, MO, USA.

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http://dx.doi.org/10.1016/j.cllc.2013.03.005DOI Listing
September 2013

Rapid induction of lung adenocarcinoma by fibroblast growth factor 9 signaling through FGF receptor 3.

Cancer Res 2013 Sep 18;73(18):5730-41. Epub 2013 Jul 18.

Authors' Affiliations: Departments of Developmental Biology, Radiology, and Medicine, Washington University School of Medicine, Saint Louis, Missouri; Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, Tokyo, Japan; and Department of Thoracic Surgery, Beijing Chaoyang Hospital, China Capital Medical University, Beijing, China.

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http://dx.doi.org/10.1158/0008-5472.CAN-13-0495DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3778117PMC
September 2013

Molecular profile of lung cancer in never smokers.

EJC Suppl 2013 Sep;11(2):248-53

Washington University School of Medicine, Department of Medicine, St. Louis, USA ; Alvin J. Siteman Cancer Center at Washington University School of Medicine, St. Louis, USA.

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http://dx.doi.org/10.1016/j.ejcsup.2013.07.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4041029PMC
September 2013

Clinical applications of The Cancer Genome Atlas project (TCGA) for squamous cell lung carcinoma.

Oncology (Williston Park) 2013 Sep;27(9):899-906

Department of Internal Medicine, St. Luke's Hospital, Chesterfield, Missouri, USA.

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September 2013

Biostatistics primer: what a clinician ought to know--prognostic and predictive factors.

J Thorac Oncol 2013 Jun;8(6):808-13

Statistics and Information Sciences, Eli Lilly and Company, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1097/JTO.0b013e318292bdcdDOI Listing
June 2013

Genomics of squamous cell lung cancer.

Oncologist 2013 Jun 31;18(6):707-16. Epub 2013 May 31.

Division of Oncology, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri 63021, USA.

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http://dx.doi.org/10.1634/theoncologist.2013-0063DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4063398PMC
June 2013

Cancer gene sequencing: ethical challenges and promises.

Virtual Mentor 2012 Nov 1;14(11):868-72. Epub 2012 Nov 1.

Saint Luke's Hospital, Chesterfield, Missouri, USA.

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http://dx.doi.org/10.1001/virtualmentor.2012.14.11.stas1-1211DOI Listing
November 2012

Clinical roundtable monograph: Recent advances in taxanes for the first-line treatment of advanced non-small cell lung cancer.

Clin Adv Hematol Oncol 2012 Oct;10(10 Suppl 18):1-16

University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

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October 2012