Ramanujan S Hegde

Ramanujan S Hegde

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Ramanujan S Hegde

Ramanujan S Hegde

Publications by authors named "Ramanujan S Hegde"

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83Publications

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Quality Control of Orphaned Proteins.

Mol Cell 2018 Aug;71(3):443-457

MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, UK. Electronic address:

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August 2018

Transmembrane Domain Recognition during Membrane Protein Biogenesis and Quality Control.

Curr Biol 2018 Apr;28(8):R498-R511

MRC Laboratory of Molecular Biology, Cambridge, CB2 0QH, UK. Electronic address:

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April 2018

The ER membrane protein complex is a transmembrane domain insertase.

Science 2018 01 14;359(6374):470-473. Epub 2017 Dec 14.

Medical Research Council (MRC) Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge CB2 0QH, UK.

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January 2018

Identification of Oxa1 Homologs Operating in the Eukaryotic Endoplasmic Reticulum.

Cell Rep 2017 Dec;21(13):3708-3716

Department of Biochemistry and Molecular Biology , The University of Chicago, 929 East 57th Street, Chicago, IL 60637, USA. Electronic address:

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December 2017

UBE2O is a quality control factor for orphans of multiprotein complexes.

Science 2017 08;357(6350):472-475

Medical Research Council (MRC) Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge, CB2 0QH, UK.

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August 2017

Initiation of Quality Control during Poly(A) Translation Requires Site-Specific Ribosome Ubiquitination.

Mol Cell 2017 Feb 5;65(4):743-750.e4. Epub 2017 Jan 5.

MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, UK. Electronic address:

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February 2017

IL-17 is a neuromodulator of Caenorhabditis elegans sensory responses.

Nature 2017 02 18;542(7639):43-48. Epub 2017 Jan 18.

MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK.

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February 2017

Mechanistic basis for a molecular triage reaction.

Science 2017 01;355(6322):298-302

Medical Research Council Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge CB2 0QH, UK.

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January 2017

Decoding Mammalian Ribosome-mRNA States by Translational GTPase Complexes.

Cell 2016 11;167(5):1229-1240.e15

MRC-LMB, Francis Crick Avenue, Cambridge CB2 0QH, UK. Electronic address:

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November 2016

Toward a structural understanding of co-translational protein translocation.

Curr Opin Cell Biol 2016 08 6;41:91-9. Epub 2016 May 6.

MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, United Kingdom. Electronic address:

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August 2016

Ubiquilins Chaperone and Triage Mitochondrial Membrane Proteins for Degradation.

Mol Cell 2016 07 23;63(1):21-33. Epub 2016 Jun 23.

MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK. Electronic address:

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July 2016

Target Selection during Protein Quality Control.

Trends Biochem Sci 2016 Feb 25;41(2):124-137. Epub 2015 Nov 25.

Medical Research Council Laboratory of Molecular Biology, Cambridge CB2 0QH, UK. Electronic address:

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February 2016

Structure of the Sec61 channel opened by a signal sequence.

Science 2016 Jan;351(6268):88-91

MRC Laboratory of Molecular Biology, Medical Research Council, Francis Crick Avenue, Cambridge CB2 0QH, UK.

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January 2016

Ribosome-associated protein quality control.

Nat Struct Mol Biol 2016 Jan;23(1):7-15

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January 2016

An allosteric Sec61 inhibitor traps nascent transmembrane helices at the lateral gate.

Elife 2014 4;3:e01483. Epub 2014 Feb 4.

Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, United States.

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November 2015

Structural basis for stop codon recognition in eukaryotes.

Nature 2015 Aug 5;524(7566):493-496. Epub 2015 Aug 5.

MRC-LMB, Francis Crick Avenue, Cambridge, CB2 0QH, UK.

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August 2015

Structures of the scanning and engaged states of the mammalian SRP-ribosome complex.

Elife 2015 Jul 9;4. Epub 2015 Jul 9.

MRC Laboratory of Molecular Biology, Cambridge, United Kingdom.

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July 2015

The ribosome quality control pathway can access nascent polypeptides stalled at the Sec61 translocon.

Mol Biol Cell 2015 Jun 15;26(12):2168-80. Epub 2015 Apr 15.

MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, United Kingdom

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June 2015

Protein targeting. Structure of the Get3 targeting factor in complex with its membrane protein cargo.

Science 2015 Mar;347(6226):1152-5

Department of Biochemistry and Molecular Biology, The University of Chicago, 929 East 57th Street, Chicago, IL 60637, USA.

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March 2015

Structure and assembly pathway of the ribosome quality control complex.

Mol Cell 2015 Feb 8;57(3):433-44. Epub 2015 Jan 8.

MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge, CB2 0QH, UK. Electronic address:

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February 2015

Cell Biology. Local synthesis and disposal.

Science 2014 Nov;346(6210):701-2

MRC Laboratory of Molecular Biology, Cambridge, CB2 0QH, UK.

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November 2014

Reconstitution of a minimal ribosome-associated ubiquitination pathway with purified factors.

Mol Cell 2014 Sep 14;55(6):880-890. Epub 2014 Aug 14.

MRC Laboratory of Molecular Biology, Cambridge, CB2 0QH, UK. Electronic address:

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September 2014

Msp1: patrolling mitochondria for lost proteins.

EMBO J 2014 Jul 10;33(14):1509-10. Epub 2014 Jun 10.

MRC Laboratory of Molecular Biology, Cambridge, UK.

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July 2014

Cytosolic quality control of mislocalized proteins requires RNF126 recruitment to Bag6.

Mol Cell 2014 Jul 26;55(2):227-37. Epub 2014 Jun 26.

MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK. Electronic address:

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July 2014

ER stress-induced clearance of misfolded GPI-anchored proteins via the secretory pathway.

Cell 2014 Jul;158(3):522-33

Cell Biology and Metabolism Program, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD 20892, USA. Electronic address:

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July 2014

Structure of the mammalian ribosome-Sec61 complex to 3.4 Å resolution.

Cell 2014 Jun 12;157(7):1632-43. Epub 2014 Jun 12.

MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge, CB2 0QH, UK. Electronic address:

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June 2014

An ER complex of ODR-4 and ODR-8/Ufm1 specific protease 2 promotes GPCR maturation by a Ufm1-independent mechanism.

PLoS Genet 2014 Mar 6;10(3):e1004082. Epub 2014 Mar 6.

MRC Laboratory of Molecular Biology, Cambridge, United Kingdom.

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March 2014

Deubiquitinases sharpen substrate discrimination during membrane protein degradation from the ER.

Cell 2013 Aug 25;154(3):609-22. Epub 2013 Jul 25.

Cell Biology and Metabolism Program, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, 18 Library Drive, Bethesda, MD 20892, USA.

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August 2013

Listerin-dependent nascent protein ubiquitination relies on ribosome subunit dissociation.

Mol Cell 2013 Jun 16;50(5):637-48. Epub 2013 May 16.

MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK.

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June 2013

Design principles of protein biosynthesis-coupled quality control.

Dev Cell 2012 Nov;23(5):896-907

MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK.

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November 2012

Membrane protein insertion at the endoplasmic reticulum.

Annu Rev Cell Dev Biol 2011 21;27:25-56. Epub 2011 Jul 21.

Cell Biology and Metabolism Program, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA.

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February 2012

A calmodulin-dependent translocation pathway for small secretory proteins.

Cell 2011 Dec;147(7):1576-88

Cell Biology and Metabolism Program, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.

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December 2011

Tail-anchored membrane protein insertion into the endoplasmic reticulum.

Nat Rev Mol Cell Biol 2011 Nov 16;12(12):787-98. Epub 2011 Nov 16.

Medical Research Council Laboratory of Molecular Biology, Cambridge, CB2 0QH, UK.

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November 2011

A conserved archaeal pathway for tail-anchored membrane protein insertion.

Traffic 2011 Sep 3;12(9):1119-23. Epub 2011 Jul 3.

Department of Biochemistry & Molecular Biology, University of Chicago, Gordon Center for Integrative Science, Room W238, Chicago, IL 60637, USA.

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September 2011

Secretory protein profiling reveals TNF-α inactivation by selective and promiscuous Sec61 modulators.

Chem Biol 2011 Sep;18(9):1082-8

Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA.

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September 2011

The mechanism of membrane-associated steps in tail-anchored protein insertion.

Nature 2011 Aug 24;477(7362):61-6. Epub 2011 Aug 24.

Cell Biology and Metabolism Program, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA.

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August 2011

A flip turn for membrane protein insertion.

Cell 2011 Jul;146(1):13-5

Cell Biology and Metabolism Program, National Institutes of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.

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July 2011

Protein targeting and degradation are coupled for elimination of mislocalized proteins.

Nature 2011 Jul 10;475(7356):394-7. Epub 2011 Jul 10.

Cell Biology and Metabolism Program, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA.

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July 2011

Cytosolic aggregates perturb the degradation of nontranslocated secretory and membrane proteins.

Mol Biol Cell 2011 May 16;22(10):1625-37. Epub 2011 Mar 16.

Cell Biology and Metabolism Program, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.

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May 2011

The life of proteins: the good, the mostly good and the ugly.

Nat Struct Mol Biol 2011 Jan;18(1):1-4

Department of Molecular Biosciences, Northwestern University, Evanston, Illinois, USA.

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January 2011

Compartment-restricted biotinylation reveals novel features of prion protein metabolism in vivo.

Mol Biol Cell 2010 Dec 27;21(24):4325-37. Epub 2010 Oct 27.

Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.

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December 2010

Quality and quantity control at the endoplasmic reticulum.

Curr Opin Cell Biol 2010 Aug 1;22(4):437-46. Epub 2010 Jun 1.

Cell Biology and Metabolism Program, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.

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August 2010

A ribosome-associating factor chaperones tail-anchored membrane proteins.

Nature 2010 Aug 1;466(7310):1120-4. Epub 2010 Aug 1.

Cell Biology and Metabolism Program, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA.

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August 2010

In vitro dissection of protein translocation into the mammalian endoplasmic reticulum.

Methods Mol Biol 2010 ;619:339-63

Cell Biology and Metabolism Program, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.

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July 2010

Regulation of basal cellular physiology by the homeostatic unfolded protein response.

J Cell Biol 2010 May;189(5):783-94

Department of Anatomy and Cell Biology, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA.

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May 2010

Signal sequence insufficiency contributes to neurodegeneration caused by transmembrane prion protein.

J Cell Biol 2010 Feb 15;188(4):515-26. Epub 2010 Feb 15.

Cell Biology and Metabolism Program, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.

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February 2010

The structural basis of tail-anchored membrane protein recognition by Get3.

Nature 2009 Sep 12;461(7262):361-6. Epub 2009 Aug 12.

Department of Biochemistry & Molecular Biology, The University of Chicago, Gordon Center for Integrative Science, Room W238, 929 East 57th Street, Chicago, Illinois 60637, USA.

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September 2009

Arginine 383 is a crucial residue in ABCG2 biogenesis.

Biochim Biophys Acta 2009 Jul 3;1788(7):1434-43. Epub 2009 May 3.

Medical Oncology Branch, National Cancer Institute, NIH, 9000 Rockville Pike, Bethesda, MD 20892, USA.

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July 2009

Prion protein biosynthesis and its emerging role in neurodegeneration.

Trends Biochem Sci 2009 Jun 15;34(6):287-95. Epub 2009 May 15.

Cell Biology and Metabolism Program, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.

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June 2009

Functional depletion of mahogunin by cytosolically exposed prion protein contributes to neurodegeneration.

Cell 2009 Jun;137(6):1136-47

Cell Biology and Metabolism Program, National Institute of Child Health and Human Development, NIH, Bethesda, MD 20892, USA.

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June 2009

Selective processing and metabolism of disease-causing mutant prion proteins.

PLoS Pathog 2009 Jun 19;5(6):e1000479. Epub 2009 Jun 19.

Cell Biology and Metabolism Program, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, United States of America.

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June 2009

Lighting up the stressed ER.

Cell 2008 Nov;135(5):787-9

National Institutes of Health, Bethesda, MD 20892, USA.

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November 2008

Reduced translocation of nascent prion protein during ER stress contributes to neurodegeneration.

Dev Cell 2008 Sep;15(3):359-70

Cell Biology and Metabolism Program, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.

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September 2008

Retrotranslocation of prion proteins from the endoplasmic reticulum by preventing GPI signal transamidation.

Mol Biol Cell 2008 Aug 28;19(8):3463-76. Epub 2008 May 28.

Cell Biology and Metabolism Program, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.

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August 2008

Single copies of Sec61 and TRAP associate with a nontranslating mammalian ribosome.

Structure 2008 Jul;16(7):1126-37

Department of Physiology and Biophysics, Boston University School of Medicine, 700 Albany Street, Boston, MA 02118-2526, USA.

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July 2008

The concept of translocational regulation.

J Cell Biol 2008 Jul 21;182(2):225-32. Epub 2008 Jul 21.

Cell Biology and Metabolism Program, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.

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July 2008

Photo-leucine incorporation reveals the target of a cyclodepsipeptide inhibitor of cotranslational translocation.

J Am Chem Soc 2007 Nov 6;129(47):14560-1. Epub 2007 Nov 6.

Department of Cellular and Molecular Pharmacology, University of California, San Francisco, California 94158, USA.

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November 2007

The role of p58IPK in protecting the stressed endoplasmic reticulum.

Mol Biol Cell 2007 Sep 13;18(9):3681-91. Epub 2007 Jun 13.

Howard Hughes Medical Institute and Departments of Biological Chemistry and Internal Medicine, University of Michigan Medical Center, Ann Arbor, MI 48109-0650, USA.

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September 2007

Relocalization of STIM1 for activation of store-operated Ca(2+) entry is determined by the depletion of subplasma membrane endoplasmic reticulum Ca(2+) store.

J Biol Chem 2007 Apr 12;282(16):12176-85. Epub 2007 Feb 12.

Secretory Physiology Section, Gene Therapy and Therapeutics Branch, NIDCR, National Institutes of Health, Bethesda, Maryland 20892, USA.

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April 2007

Intracellular Ca(2+) release via the ER translocon activates store-operated calcium entry.

Pflugers Arch 2007 Mar 14;453(6):797-808. Epub 2006 Dec 14.

Secretory Physiology Section, Gene Therapy and Therapeutics Branch, National Institute of Dental and Craniofacial Research, Bethesda, MD 20892, USA.

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March 2007

Identification of a targeting factor for posttranslational membrane protein insertion into the ER.

Cell 2007 Mar;128(6):1147-59

Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.

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March 2007

Substrate-specific translocational attenuation during ER stress defines a pre-emptive quality control pathway.

Cell 2006 Dec;127(5):999-1013

Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, National Institutes of Health, 18 Library Drive, Building 18T, Room 101, Bethesda, MD 20892, USA.

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December 2006

The surprising complexity of signal sequences.

Trends Biochem Sci 2006 Oct 21;31(10):563-71. Epub 2006 Aug 21.

Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.

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October 2006

Rational design and evaluation of FRET experiments to measure protein proximities in cells.

Curr Protoc Cell Biol 2006 Oct;Chapter 17:Unit 17.9

Albert Einstein College of Medicine, Bronx, New York, USA.

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October 2006

Prions and retroviruses: an endosomal rendezvous?

EMBO Rep 2006 Jul;7(7):685-7

Cell Biology and Metabolism Branch of the National Institute of Child Health and Human Development, National Institutes of Health, 18 Library Drive, Building 18, Room 101, Bethesda, MD 20892, USA.

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July 2006

Monitoring chaperone engagement of substrates in the endoplasmic reticulum of live cells.

Proc Natl Acad Sci U S A 2006 Apr 14;103(17):6536-41. Epub 2006 Apr 14.

Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, National Institutes of Health, 18 Library Drive, Building 18, Room 101, Bethesda, MD 20892, USA.

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April 2006

Regulation of protein compartmentalization expands the diversity of protein function.

Dev Cell 2005 Oct;9(4):545-54

Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.

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October 2005

Transmembrane topogenesis of a tail-anchored protein is modulated by membrane lipid composition.

EMBO J 2005 Jul 23;24(14):2533-42. Epub 2005 Jun 23.

CNR Institute of Neuroscience - Cell Mol Pharmacology - and Department of Medical Pharmacology, University of Milan, Milan, Italy.

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July 2005

A substrate-specific inhibitor of protein translocation into the endoplasmic reticulum.

Nature 2005 Jul;436(7048):285-9

Department of Cellular and Molecular Pharmacology, University of California, San Francisco, California 94107, USA.

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July 2005

Architecture of the ribosome-channel complex derived from native membranes.

J Mol Biol 2005 Apr;348(2):445-57

Department of Physiology and Biophysics, Boston University School of Medicine, 700 Albany St., Boston, MA 02118-2526, USA.

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April 2005

The efficiency of protein compartmentalization into the secretory pathway.

Mol Biol Cell 2005 Jan 20;16(1):279-91. Epub 2004 Oct 20.

Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.

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January 2005

Protection from cytosolic prion protein toxicity by modulation of protein translocation.

EMBO J 2004 Nov 4;23(23):4550-9. Epub 2004 Nov 4.

Cell Biology and Metabolism Branch, NICHD, National Institutes of Health, Bethesda, MD 20892-5430, USA.

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November 2004

Transmembrane domain modulates sorting of membrane proteins in Toxoplasma gondii.

J Biol Chem 2004 Jun 31;279(25):26052-7. Epub 2004 Mar 31.

Section of Infectious Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520, USA.

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June 2004

The organization of engaged and quiescent translocons in the endoplasmic reticulum of mammalian cells.

J Cell Biol 2004 Mar;164(7):997-1007

Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, National Institutes of Health, 18 Library Dr., Bldg. 18, Rm. 101, Bethesda, MD 20892, USA.

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March 2004

Mutant PrPSc conformers induced by a synthetic peptide and several prion strains.

J Virol 2004 Feb;78(4):2088-99

Institute for Neurodegenerative Diseases and Department of Neurology, University of California, San Francisco, California 94143, USA.

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February 2004

Formation of stacked ER cisternae by low affinity protein interactions.

J Cell Biol 2003 Oct;163(2):257-69

Cell Biology and Metabolism Branch, National Institutes of Child Health and Human Development, National Institutes of Health, 18 Library Dr., Bldg. 18T, Rm. 101, Bethesda, MD 20892, USA.

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October 2003

Prion protein trafficking and the development of neurodegeneration.

Trends Neurosci 2003 Jul;26(7):337-9

Cell Biology and Metabolism Branch, NICHD/National Institutes of Health, Bethesda, MD 20892, USA.

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July 2003

Substrate-specific function of the translocon-associated protein complex during translocation across the ER membrane.

J Cell Biol 2003 Feb 10;160(4):529-39. Epub 2003 Feb 10.

Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.

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February 2003

Cotranslational partitioning of nascent prion protein into multiple populations at the translocation channel.

Mol Biol Cell 2002 Nov;13(11):3775-86

Laboratory of Cellular Oncology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.

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November 2002

Targeting and beyond: new roles for old signal sequences.

Mol Cell 2002 Oct;10(4):697-8

Cell Biology and Metabolism Branch, NICHD, National Institutes of Health, Bethesda, MD 20892, USA.

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October 2002

Conformational control through translocational regulation: a new view of secretory and membrane protein folding.

Bioessays 2002 Aug;24(8):741-8

Department of Physiology, University of California, San Francisco, CA 94143-0444, USA.

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August 2002

Signal sequences control gating of the protein translocation channel in a substrate-specific manner.

Dev Cell 2002 Feb;2(2):207-17

Laboratory of Cellular Oncology, National Cancer Institute, Bethesda, MD 20892, USA.

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February 2002