Ramanujan S Hegde

Ramanujan S Hegde

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Ramanujan S Hegde

Publications by authors named "Ramanujan S Hegde"

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ZNF598 Is a Quality Control Sensor of Collided Ribosomes.

Mol Cell 2018 Nov 4;72(3):469-481.e7. Epub 2018 Oct 4.

MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, UK. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2018.08.037DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6224477PMC
November 2018

EMC Is Required to Initiate Accurate Membrane Protein Topogenesis.

Cell 2018 Nov 8;175(6):1507-1519.e16. Epub 2018 Nov 8.

MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S00928674183131
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http://dx.doi.org/10.1016/j.cell.2018.10.009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6269167PMC
November 2018

Quality Control of Orphaned Proteins.

Mol Cell 2018 Aug;71(3):443-457

MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, UK. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2018.07.001DOI Listing
August 2018

Transmembrane Domain Recognition during Membrane Protein Biogenesis and Quality Control.

Curr Biol 2018 Apr;28(8):R498-R511

MRC Laboratory of Molecular Biology, Cambridge, CB2 0QH, UK. Electronic address:

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http://dx.doi.org/10.1016/j.cub.2018.02.004DOI Listing
April 2018

The ER membrane protein complex is a transmembrane domain insertase.

Science 2018 01 14;359(6374):470-473. Epub 2017 Dec 14.

Medical Research Council (MRC) Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge CB2 0QH, UK.

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http://dx.doi.org/10.1126/science.aao3099DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5788257PMC
January 2018

Identification of Oxa1 Homologs Operating in the Eukaryotic Endoplasmic Reticulum.

Cell Rep 2017 12;21(13):3708-3716

Department of Biochemistry and Molecular Biology , The University of Chicago, 929 East 57th Street, Chicago, IL 60637, USA. Electronic address:

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http://dx.doi.org/10.1016/j.celrep.2017.12.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5868721PMC
December 2017

UBE2O is a quality control factor for orphans of multiprotein complexes.

Science 2017 08;357(6350):472-475

Medical Research Council (MRC) Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge, CB2 0QH, UK.

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http://dx.doi.org/10.1126/science.aan0178DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5549844PMC
August 2017

Initiation of Quality Control during Poly(A) Translation Requires Site-Specific Ribosome Ubiquitination.

Mol Cell 2017 Feb 5;65(4):743-750.e4. Epub 2017 Jan 5.

MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, UK. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2016.11.039DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5316413PMC
February 2017

IL-17 is a neuromodulator of Caenorhabditis elegans sensory responses.

Nature 2017 02 18;542(7639):43-48. Epub 2017 Jan 18.

MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK.

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http://dx.doi.org/10.1038/nature20818DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5503128PMC
February 2017

Mechanistic basis for a molecular triage reaction.

Science 2017 01;355(6322):298-302

Medical Research Council Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge Biomedical Campus, Cambridge CB2 0QH, UK.

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http://www.sciencemag.org/lookup/doi/10.1126/science.aah6130
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http://dx.doi.org/10.1126/science.aah6130DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5380214PMC
January 2017

Decoding Mammalian Ribosome-mRNA States by Translational GTPase Complexes.

Cell 2016 11;167(5):1229-1240.e15

MRC-LMB, Francis Crick Avenue, Cambridge CB2 0QH, UK. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2016.10.046DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5119991PMC
November 2016

Toward a structural understanding of co-translational protein translocation.

Curr Opin Cell Biol 2016 08 6;41:91-9. Epub 2016 May 6.

MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, United Kingdom. Electronic address:

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http://dx.doi.org/10.1016/j.ceb.2016.04.009DOI Listing
August 2016

Ubiquilins Chaperone and Triage Mitochondrial Membrane Proteins for Degradation.

Mol Cell 2016 07 23;63(1):21-33. Epub 2016 Jun 23.

MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2016.05.020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4942676PMC
July 2016

Target Selection during Protein Quality Control.

Trends Biochem Sci 2016 Feb 25;41(2):124-137. Epub 2015 Nov 25.

Medical Research Council Laboratory of Molecular Biology, Cambridge CB2 0QH, UK. Electronic address:

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http://dx.doi.org/10.1016/j.tibs.2015.10.007DOI Listing
February 2016

Structure of the Sec61 channel opened by a signal sequence.

Science 2016 Jan;351(6268):88-91

MRC Laboratory of Molecular Biology, Medical Research Council, Francis Crick Avenue, Cambridge CB2 0QH, UK.

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http://dx.doi.org/10.1126/science.aad4992DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4700591PMC
January 2016

An allosteric Sec61 inhibitor traps nascent transmembrane helices at the lateral gate.

Elife 2014 4;3:e01483. Epub 2014 Feb 4.

Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, United States.

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https://elifesciences.org/articles/01483
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http://dx.doi.org/10.7554/eLife.01483DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3913039PMC
November 2015

Structural basis for stop codon recognition in eukaryotes.

Nature 2015 Aug 5;524(7566):493-496. Epub 2015 Aug 5.

MRC-LMB, Francis Crick Avenue, Cambridge, CB2 0QH, UK.

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http://dx.doi.org/10.1038/nature14896DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4591471PMC
August 2015

Structures of the scanning and engaged states of the mammalian SRP-ribosome complex.

Elife 2015 Jul 9;4. Epub 2015 Jul 9.

MRC Laboratory of Molecular Biology, Cambridge, United Kingdom.

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http://dx.doi.org/10.7554/eLife.07975DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4497383PMC
July 2015

The ribosome quality control pathway can access nascent polypeptides stalled at the Sec61 translocon.

Mol Biol Cell 2015 Jun 15;26(12):2168-80. Epub 2015 Apr 15.

MRC Laboratory of Molecular Biology, Cambridge CB2 0QH, United Kingdom

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http://dx.doi.org/10.1091/mbc.E15-01-0040DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4462936PMC
June 2015

Protein targeting. Structure of the Get3 targeting factor in complex with its membrane protein cargo.

Science 2015 Mar;347(6226):1152-5

Department of Biochemistry and Molecular Biology, The University of Chicago, 929 East 57th Street, Chicago, IL 60637, USA.

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http://dx.doi.org/10.1126/science.1261671DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4413028PMC
March 2015

Structure and assembly pathway of the ribosome quality control complex.

Mol Cell 2015 Feb 8;57(3):433-44. Epub 2015 Jan 8.

MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge, CB2 0QH, UK. Electronic address:

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http://dx.doi.org/10.1016/j.molcel.2014.12.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4321881PMC
February 2015

Cell Biology. Local synthesis and disposal.

Science 2014 Nov;346(6210):701-2

MRC Laboratory of Molecular Biology, Cambridge, CB2 0QH, UK.

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http://www.sciencemag.org/cgi/doi/10.1126/science.1261602
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http://dx.doi.org/10.1126/science.1261602DOI Listing
November 2014

Reconstitution of a minimal ribosome-associated ubiquitination pathway with purified factors.

Mol Cell 2014 Sep 14;55(6):880-890. Epub 2014 Aug 14.

MRC Laboratory of Molecular Biology, Cambridge, CB2 0QH, UK. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10972765140059
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http://dx.doi.org/10.1016/j.molcel.2014.07.006DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4175178PMC
September 2014

Msp1: patrolling mitochondria for lost proteins.

EMBO J 2014 Jul 10;33(14):1509-10. Epub 2014 Jun 10.

MRC Laboratory of Molecular Biology, Cambridge, UK.

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http://dx.doi.org/10.15252/embj.201488930DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4198047PMC
July 2014

Cytosolic quality control of mislocalized proteins requires RNF126 recruitment to Bag6.

Mol Cell 2014 Jul 26;55(2):227-37. Epub 2014 Jun 26.

MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S10972765140044
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http://dx.doi.org/10.1016/j.molcel.2014.05.025DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4104027PMC
July 2014

ER stress-induced clearance of misfolded GPI-anchored proteins via the secretory pathway.

Cell 2014 Jul;158(3):522-33

Cell Biology and Metabolism Program, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD 20892, USA. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2014.06.026DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4121523PMC
July 2014

Structure of the mammalian ribosome-Sec61 complex to 3.4 Å resolution.

Cell 2014 Jun 12;157(7):1632-43. Epub 2014 Jun 12.

MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge, CB2 0QH, UK. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2014.05.024DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4081569PMC
June 2014

Deubiquitinases sharpen substrate discrimination during membrane protein degradation from the ER.

Cell 2013 Aug 25;154(3):609-22. Epub 2013 Jul 25.

Cell Biology and Metabolism Program, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, 18 Library Drive, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1016/j.cell.2013.06.038DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3732389PMC
August 2013

Listerin-dependent nascent protein ubiquitination relies on ribosome subunit dissociation.

Mol Cell 2013 Jun 16;50(5):637-48. Epub 2013 May 16.

MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK.

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http://dx.doi.org/10.1016/j.molcel.2013.04.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3719020PMC
June 2013

Design principles of protein biosynthesis-coupled quality control.

Dev Cell 2012 Nov;23(5):896-907

MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 0QH, UK.

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http://dx.doi.org/10.1016/j.devcel.2012.10.012DOI Listing
November 2012

Membrane protein insertion at the endoplasmic reticulum.

Annu Rev Cell Dev Biol 2011 21;27:25-56. Epub 2011 Jul 21.

Cell Biology and Metabolism Program, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA.

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http://www.annualreviews.org/doi/10.1146/annurev-cellbio-092
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http://dx.doi.org/10.1146/annurev-cellbio-092910-154125DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4163802PMC
February 2012

A calmodulin-dependent translocation pathway for small secretory proteins.

Cell 2011 Dec;147(7):1576-88

Cell Biology and Metabolism Program, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1016/j.cell.2011.11.048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3277827PMC
December 2011

Tail-anchored membrane protein insertion into the endoplasmic reticulum.

Nat Rev Mol Cell Biol 2011 Nov 16;12(12):787-98. Epub 2011 Nov 16.

Medical Research Council Laboratory of Molecular Biology, Cambridge, CB2 0QH, UK.

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http://dx.doi.org/10.1038/nrm3226DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3760496PMC
November 2011

A conserved archaeal pathway for tail-anchored membrane protein insertion.

Traffic 2011 Sep 3;12(9):1119-23. Epub 2011 Jul 3.

Department of Biochemistry & Molecular Biology, University of Chicago, Gordon Center for Integrative Science, Room W238, Chicago, IL 60637, USA.

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http://dx.doi.org/10.1111/j.1600-0854.2011.01229.xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3155638PMC
September 2011

The mechanism of membrane-associated steps in tail-anchored protein insertion.

Nature 2011 Aug 24;477(7362):61-6. Epub 2011 Aug 24.

Cell Biology and Metabolism Program, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1038/nature10362DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3760497PMC
August 2011

A flip turn for membrane protein insertion.

Cell 2011 Jul;146(1):13-5

Cell Biology and Metabolism Program, National Institutes of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1016/j.cell.2011.06.028DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4162087PMC
July 2011

Protein targeting and degradation are coupled for elimination of mislocalized proteins.

Nature 2011 Jul 10;475(7356):394-7. Epub 2011 Jul 10.

Cell Biology and Metabolism Program, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1038/nature10181DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3150218PMC
July 2011

Cytosolic aggregates perturb the degradation of nontranslocated secretory and membrane proteins.

Mol Biol Cell 2011 May 16;22(10):1625-37. Epub 2011 Mar 16.

Cell Biology and Metabolism Program, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1091/mbc.E10-07-0638DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3093316PMC
May 2011

The life of proteins: the good, the mostly good and the ugly.

Nat Struct Mol Biol 2011 Jan;18(1):1-4

Department of Molecular Biosciences, Northwestern University, Evanston, Illinois, USA.

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http://dx.doi.org/10.1038/nsmb0111-1DOI Listing
January 2011

Compartment-restricted biotinylation reveals novel features of prion protein metabolism in vivo.

Mol Biol Cell 2010 Dec 27;21(24):4325-37. Epub 2010 Oct 27.

Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1091/mbc.E10-09-0742DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3002386PMC
December 2010

Quality and quantity control at the endoplasmic reticulum.

Curr Opin Cell Biol 2010 Aug 1;22(4):437-46. Epub 2010 Jun 1.

Cell Biology and Metabolism Program, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1016/j.ceb.2010.05.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2929805PMC
August 2010

A ribosome-associating factor chaperones tail-anchored membrane proteins.

Nature 2010 Aug 1;466(7310):1120-4. Epub 2010 Aug 1.

Cell Biology and Metabolism Program, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1038/nature09296DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2928861PMC
August 2010

In vitro dissection of protein translocation into the mammalian endoplasmic reticulum.

Methods Mol Biol 2010 ;619:339-63

Cell Biology and Metabolism Program, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.

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http://dx.doi.org/10.1007/978-1-60327-412-8_20DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3122127PMC
July 2010

Regulation of basal cellular physiology by the homeostatic unfolded protein response.

J Cell Biol 2010 May;189(5):783-94

Department of Anatomy and Cell Biology, Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA.

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http://dx.doi.org/10.1083/jcb.201003138DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2878945PMC
May 2010

Signal sequence insufficiency contributes to neurodegeneration caused by transmembrane prion protein.

J Cell Biol 2010 Feb 15;188(4):515-26. Epub 2010 Feb 15.

Cell Biology and Metabolism Program, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1083/jcb.200911115DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2828915PMC
February 2010

The structural basis of tail-anchored membrane protein recognition by Get3.

Nature 2009 Sep 12;461(7262):361-6. Epub 2009 Aug 12.

Department of Biochemistry & Molecular Biology, The University of Chicago, Gordon Center for Integrative Science, Room W238, 929 East 57th Street, Chicago, Illinois 60637, USA.

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http://dx.doi.org/10.1038/nature08319DOI Listing
September 2009

Arginine 383 is a crucial residue in ABCG2 biogenesis.

Biochim Biophys Acta 2009 Jul 3;1788(7):1434-43. Epub 2009 May 3.

Medical Oncology Branch, National Cancer Institute, NIH, 9000 Rockville Pike, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1016/j.bbamem.2009.04.016DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4163909PMC
July 2009

Prion protein biosynthesis and its emerging role in neurodegeneration.

Trends Biochem Sci 2009 Jun 15;34(6):287-95. Epub 2009 May 15.

Cell Biology and Metabolism Program, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1016/j.tibs.2009.03.001DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3132587PMC
June 2009

Functional depletion of mahogunin by cytosolically exposed prion protein contributes to neurodegeneration.

Cell 2009 Jun;137(6):1136-47

Cell Biology and Metabolism Program, National Institute of Child Health and Human Development, NIH, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1016/j.cell.2009.03.042DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2709807PMC
June 2009

Selective processing and metabolism of disease-causing mutant prion proteins.

PLoS Pathog 2009 Jun 19;5(6):e1000479. Epub 2009 Jun 19.

Cell Biology and Metabolism Program, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, United States of America.

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http://dx.doi.org/10.1371/journal.ppat.1000479DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2691595PMC
June 2009

Lighting up the stressed ER.

Cell 2008 Nov;135(5):787-9

National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1016/j.cell.2008.11.004DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3117787PMC
November 2008

Reduced translocation of nascent prion protein during ER stress contributes to neurodegeneration.

Dev Cell 2008 Sep;15(3):359-70

Cell Biology and Metabolism Program, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1016/j.devcel.2008.06.015DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2563805PMC
September 2008

Retrotranslocation of prion proteins from the endoplasmic reticulum by preventing GPI signal transamidation.

Mol Biol Cell 2008 Aug 28;19(8):3463-76. Epub 2008 May 28.

Cell Biology and Metabolism Program, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1091/mbc.e08-01-0087DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2488287PMC
August 2008

Single copies of Sec61 and TRAP associate with a nontranslating mammalian ribosome.

Structure 2008 Jul;16(7):1126-37

Department of Physiology and Biophysics, Boston University School of Medicine, 700 Albany Street, Boston, MA 02118-2526, USA.

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http://dx.doi.org/10.1016/j.str.2008.05.003DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2527209PMC
July 2008

The concept of translocational regulation.

J Cell Biol 2008 Jul 21;182(2):225-32. Epub 2008 Jul 21.

Cell Biology and Metabolism Program, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1083/jcb.200804157DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2483521PMC
July 2008

Photo-leucine incorporation reveals the target of a cyclodepsipeptide inhibitor of cotranslational translocation.

J Am Chem Soc 2007 Nov 6;129(47):14560-1. Epub 2007 Nov 6.

Department of Cellular and Molecular Pharmacology, University of California, San Francisco, California 94158, USA.

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http://dx.doi.org/10.1021/ja076250yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2574519PMC
November 2007

The role of p58IPK in protecting the stressed endoplasmic reticulum.

Mol Biol Cell 2007 Sep 13;18(9):3681-91. Epub 2007 Jun 13.

Howard Hughes Medical Institute and Departments of Biological Chemistry and Internal Medicine, University of Michigan Medical Center, Ann Arbor, MI 48109-0650, USA.

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http://dx.doi.org/10.1091/mbc.e07-03-0272DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1951758PMC
September 2007

Intracellular Ca(2+) release via the ER translocon activates store-operated calcium entry.

Pflugers Arch 2007 Mar 14;453(6):797-808. Epub 2006 Dec 14.

Secretory Physiology Section, Gene Therapy and Therapeutics Branch, National Institute of Dental and Craniofacial Research, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1007/s00424-006-0163-5DOI Listing
March 2007

Identification of a targeting factor for posttranslational membrane protein insertion into the ER.

Cell 2007 Mar;128(6):1147-59

Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1016/j.cell.2007.01.036DOI Listing
March 2007

Substrate-specific translocational attenuation during ER stress defines a pre-emptive quality control pathway.

Cell 2006 Dec;127(5):999-1013

Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, National Institutes of Health, 18 Library Drive, Building 18T, Room 101, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1016/j.cell.2006.10.032DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3656606PMC
December 2006

The surprising complexity of signal sequences.

Trends Biochem Sci 2006 Oct 21;31(10):563-71. Epub 2006 Aug 21.

Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1016/j.tibs.2006.08.004DOI Listing
October 2006

Rational design and evaluation of FRET experiments to measure protein proximities in cells.

Curr Protoc Cell Biol 2006 Oct;Chapter 17:Unit 17.9

Albert Einstein College of Medicine, Bronx, New York, USA.

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http://dx.doi.org/10.1002/0471143030.cb1709s32DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2875078PMC
October 2006

Prions and retroviruses: an endosomal rendezvous?

EMBO Rep 2006 Jul;7(7):685-7

Cell Biology and Metabolism Branch of the National Institute of Child Health and Human Development, National Institutes of Health, 18 Library Drive, Building 18, Room 101, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1038/sj.embor.7400749DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1500823PMC
July 2006

Monitoring chaperone engagement of substrates in the endoplasmic reticulum of live cells.

Proc Natl Acad Sci U S A 2006 Apr 14;103(17):6536-41. Epub 2006 Apr 14.

Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, National Institutes of Health, 18 Library Drive, Building 18, Room 101, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1073/pnas.0510657103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1458919PMC
April 2006

Regulation of protein compartmentalization expands the diversity of protein function.

Dev Cell 2005 Oct;9(4):545-54

Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1016/j.devcel.2005.09.001DOI Listing
October 2005

Transmembrane topogenesis of a tail-anchored protein is modulated by membrane lipid composition.

EMBO J 2005 Jul 23;24(14):2533-42. Epub 2005 Jun 23.

CNR Institute of Neuroscience - Cell Mol Pharmacology - and Department of Medical Pharmacology, University of Milan, Milan, Italy.

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http://dx.doi.org/10.1038/sj.emboj.7600730DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1176458PMC
July 2005

A substrate-specific inhibitor of protein translocation into the endoplasmic reticulum.

Nature 2005 Jul;436(7048):285-9

Department of Cellular and Molecular Pharmacology, University of California, San Francisco, California 94107, USA.

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http://www.nature.com/articles/nature03821
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July 2005

Architecture of the ribosome-channel complex derived from native membranes.

J Mol Biol 2005 Apr;348(2):445-57

Department of Physiology and Biophysics, Boston University School of Medicine, 700 Albany St., Boston, MA 02118-2526, USA.

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http://dx.doi.org/10.1016/j.jmb.2005.02.053DOI Listing
April 2005

The efficiency of protein compartmentalization into the secretory pathway.

Mol Biol Cell 2005 Jan 20;16(1):279-91. Epub 2004 Oct 20.

Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.

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http://www.molbiolcell.org/doi/10.1091/mbc.e04-06-0508
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC539172PMC
January 2005

Protection from cytosolic prion protein toxicity by modulation of protein translocation.

EMBO J 2004 Nov 4;23(23):4550-9. Epub 2004 Nov 4.

Cell Biology and Metabolism Branch, NICHD, National Institutes of Health, Bethesda, MD 20892-5430, USA.

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http://emboj.embopress.org/cgi/doi/10.1038/sj.emboj.7600462
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC533048PMC
November 2004

Transmembrane domain modulates sorting of membrane proteins in Toxoplasma gondii.

J Biol Chem 2004 Jun 31;279(25):26052-7. Epub 2004 Mar 31.

Section of Infectious Diseases, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520, USA.

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http://dx.doi.org/10.1074/jbc.M400480200DOI Listing
June 2004

The organization of engaged and quiescent translocons in the endoplasmic reticulum of mammalian cells.

J Cell Biol 2004 Mar;164(7):997-1007

Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, National Institutes of Health, 18 Library Dr., Bldg. 18, Rm. 101, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1083/jcb.200312079DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2172055PMC
March 2004

Mutant PrPSc conformers induced by a synthetic peptide and several prion strains.

J Virol 2004 Feb;78(4):2088-99

Institute for Neurodegenerative Diseases and Department of Neurology, University of California, San Francisco, California 94143, USA.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC369494PMC
February 2004

Formation of stacked ER cisternae by low affinity protein interactions.

J Cell Biol 2003 Oct;163(2):257-69

Cell Biology and Metabolism Branch, National Institutes of Child Health and Human Development, National Institutes of Health, 18 Library Dr., Bldg. 18T, Rm. 101, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1083/jcb.200306020DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2173526PMC
October 2003

Prion protein trafficking and the development of neurodegeneration.

Trends Neurosci 2003 Jul;26(7):337-9

Cell Biology and Metabolism Branch, NICHD/National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1016/S0166-2236(03)00143-7DOI Listing
July 2003

Substrate-specific function of the translocon-associated protein complex during translocation across the ER membrane.

J Cell Biol 2003 Feb 10;160(4):529-39. Epub 2003 Feb 10.

Cell Biology and Metabolism Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.

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http://dx.doi.org/10.1083/jcb.200210095DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2173754PMC
February 2003

Cotranslational partitioning of nascent prion protein into multiple populations at the translocation channel.

Mol Biol Cell 2002 Nov;13(11):3775-86

Laboratory of Cellular Oncology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.

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http://dx.doi.org/10.1091/mbc.e02-05-0293DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC133591PMC
November 2002

Targeting and beyond: new roles for old signal sequences.

Mol Cell 2002 Oct;10(4):697-8

Cell Biology and Metabolism Branch, NICHD, National Institutes of Health, Bethesda, MD 20892, USA.

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October 2002

Conformational control through translocational regulation: a new view of secretory and membrane protein folding.

Bioessays 2002 Aug;24(8):741-8

Department of Physiology, University of California, San Francisco, CA 94143-0444, USA.

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http://doi.wiley.com/10.1002/bies.10130
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August 2002

Signal sequences control gating of the protein translocation channel in a substrate-specific manner.

Dev Cell 2002 Feb;2(2):207-17

Laboratory of Cellular Oncology, National Cancer Institute, Bethesda, MD 20892, USA.

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February 2002