Publications by authors named "Ramakrishna Edupuganti"

17Publications

Computational and Experimental Studies of Inhibitor Design for Aldolase A.

J Phys Chem B 2019 07 3;123(28):6034-6041. Epub 2019 Jul 3.

Department of Biochemistry and Mathematics , University of Michigan , Ann Arbor , Michigan 48109 , United States.

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http://dx.doi.org/10.1021/acs.jpcb.9b04551DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6935369PMC
July 2019

Computational insights into the binding of IN17 inhibitors to MELK.

J Mol Model 2019 May 8;25(6):151. Epub 2019 May 8.

Department of Biomedical Engineering, The University of Texas at Austin, Austin, TX, 78712, USA.

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http://dx.doi.org/10.1007/s00894-019-4036-1DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7105934PMC
May 2019

A c-Jun N-terminal kinase inhibitor, JNK-IN-8, sensitizes triple negative breast cancer cells to lapatinib.

Oncotarget 2017 Dec 24;8(62):104894-104912. Epub 2017 Aug 24.

Institute of Cellular & Molecular Biology, University of Texas at Austin, Dell Pediatric Research Institute, Austin, TX 78723, USA.

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http://dx.doi.org/10.18632/oncotarget.20581DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5739608PMC
December 2017

Serotonin Analogues as Inhibitors of Breast Cancer Cell Growth.

ACS Med Chem Lett 2017 Oct 14;8(10):1072-1076. Epub 2017 Sep 14.

Division of Chemical Biology and Medicinal Chemistry, College of Pharmacy, University of Texas at Austin, Austin, Texas 78712, United States.

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http://dx.doi.org/10.1021/acsmedchemlett.7b00282DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5641961PMC
October 2017

Discovery of a potent inhibitor of MELK that inhibits expression of the anti-apoptotic protein Mcl-1 and TNBC cell growth.

Bioorg Med Chem 2017 05 10;25(9):2609-2616. Epub 2017 Mar 10.

Division of Chemical Biology & Medicinal Chemistry, The University of Texas at Austin, TX 78712, USA; The Targeted Drug Discovery and Development Program, College of Pharmacy, The University of Texas at Austin, TX 78712, USA. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S09680896173019
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http://dx.doi.org/10.1016/j.bmc.2017.03.018DOI Listing
May 2017

Synthesis and structural analyses of phenylethynyl-substituted tris(2-pyridylmethyl)amines and their copper(ii) complexes.

Dalton Trans 2016 Jun;45(26):10585-98

Department of Chemistry, The University of Texas at Austin, Austin, Texas 78752, USA.

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http://dx.doi.org/10.1039/c6dt00473cDOI Listing
June 2016

Using docking and alchemical free energy approach to determine the binding mechanism of eEF2K inhibitors and prioritizing the compound synthesis.

Front Mol Biosci 2015 19;2. Epub 2015 Mar 19.

Department of Biomedical Engineering, Cockrell School of Engineering, The University of Texas at Austin Austin, TX, USA.

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http://dx.doi.org/10.3389/fmolb.2015.00009DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4429643PMC
May 2015

Quantification of a Pharmacodynamic ERK End Point in Melanoma Cell Lysates: Toward Personalized Precision Medicine.

ACS Med Chem Lett 2015 Jan 17;6(1):47-52. Epub 2014 Oct 17.

Division of Medicinal Chemistry, College of Pharmacy, Department of Biomedical Engineering, and Department of Chemistry, The University of Texas , Austin, Texas 78712, United States.

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http://pubs.acs.org/doi/10.1021/ml500198b
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http://dx.doi.org/10.1021/ml500198bDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4291693PMC
January 2015

Mechanistic Studies on Covalent Assemblies of Metal-Mediated Hemi-Aminal Ethers.

Chem Sci 2015 Jan;6(1):158-164

Department of Chemistry, The University of Texas at Austin, Austin, Texas, 78712, USA.

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http://xlink.rsc.org/?DOI=C4SC02495H
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http://dx.doi.org/10.1039/C4SC02495HDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4267293PMC
January 2015

Reversible covalent inhibition of eEF-2K by carbonitriles.

Chembiochem 2014 Nov 15;15(16):2435-42. Epub 2014 Sep 15.

Texas Screening Alliance for Cancer Therapeutics, The University of Texas at Austin, 105 E. 24th Street, Stop A5300, Austin, TX 78712 (USA).

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http://dx.doi.org/10.1002/cbic.201402321DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6482285PMC
November 2014

Synthesis and biological evaluation of pyrido[2,3-d]pyrimidine-2,4-dione derivatives as eEF-2K inhibitors.

Bioorg Med Chem 2014 Sep 30;22(17):4910-6. Epub 2014 Jun 30.

Division of Medicinal Chemistry, College of Pharmacy, The University of Texas at Austin, TX 78712, USA; Graduate Program in Cell and Molecular Biology, The University of Texas at Austin, TX 78712, USA. Electronic address:

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http://dx.doi.org/10.1016/j.bmc.2014.06.050DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6473179PMC
September 2014

Exploring naphthyl-carbohydrazides as inhibitors of influenza A viruses.

Eur J Med Chem 2014 Jan 7;71:81-90. Epub 2013 Nov 7.

Department of Chemistry, University of Texas at Austin, Austin, TX 78712, USA. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2013.10.063DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4545637PMC
January 2014

High-throughput screens for eEF-2 kinase.

J Biomol Screen 2014 Mar 27;19(3):445-52. Epub 2013 Sep 27.

1Texas Screening Alliance for Cancer Therapeutics, The University of Texas at Austin, TX, USA.

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http://dx.doi.org/10.1177/1087057113505204DOI Listing
March 2014

Synthesis and applications of masked oxo-sulfinamides in asymmetric synthesis.

Org Biomol Chem 2012 Jul 11;10(26):5021-31. Epub 2012 May 11.

Department of Chemistry, Temple University, Philadelphia, PA 19122, USA.

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http://dx.doi.org/10.1039/c2ob25345cDOI Listing
July 2012