Ram A Vishwakarma

Ram A Vishwakarma

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Ram A Vishwakarma

Ram A Vishwakarma

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Chemical analysis of saffron by HPLC based crocetin estimation.

J Pharm Biomed Anal 2020 Mar 3;181:113094. Epub 2020 Jan 3.

Preformulation Laboratory, PK-PD Toxicology and Formulation Division, CSIR- Indian Institute of Integrative Medicine, Canal Road, Jammu, 180001, India. Electronic address:

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http://dx.doi.org/10.1016/j.jpba.2020.113094DOI Listing
March 2020

Evaluation of rohitukine-enriched fraction of Dysoxylum binectariferum Hook.f. (leaves) as anti-arthritic phytopharmaceutical candidate: Chemical standardization, in-vivo validation, formulation development and oral pharmacokinetics.

J Ethnopharmacol 2020 Mar 9;254:112758. Epub 2020 Mar 9.

Academy of Scientific & Innovative Research (AcSIR), CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu, 180001, India; Medicinal Chemistry Division, Indian Institute of Integrative Medicine (CSIR), Canal Road, Jammu, 180001, India. Electronic address:

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http://dx.doi.org/10.1016/j.jep.2020.112758DOI Listing
March 2020

Differentiation of human neuroblastoma cell line IMR-32 by sildenafil and its newly discovered analogue IS00384.

Cell Signal 2020 Jan 2;65:109425. Epub 2019 Nov 2.

CSIR- Indian Institute of Integrative Medicine, Sanatnagar, Srinagar, Kashmir, India; Academy of Scientific and Innovative Research, India. Electronic address:

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http://dx.doi.org/10.1016/j.cellsig.2019.109425DOI Listing
January 2020

A Comprehensive Transcriptome-Wide Identification and Screening of WRKY Gene Family Engaged in Abiotic Stress in Glycyrrhiza glabra.

Sci Rep 2020 Jan 15;10(1):373. Epub 2020 Jan 15.

Plant Biotechnology Department, Council for Scientific Research-Indian Institute of Integrative Medicine, Canal Road, Jammu, India.

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http://dx.doi.org/10.1038/s41598-019-57232-xDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6962277PMC
January 2020

Corrigendum to "Design, synthesis and biological evaluation of pyrazolopyrimidinone based potent and selective PDE5 inhibitors for treatment of erectile dysfunction" [Bioorg. Chem. 89 (2019) 103022].

Bioorg Chem 2019 Nov 13;92:103257. Epub 2019 Sep 13.

Medicinal Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu 180 001, India; Academy of Scientific and Innovative Research, Anusandhan Bhawan, 2 Rafi Marg, New Delhi 110 001, India. Electronic address:

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http://dx.doi.org/10.1016/j.bioorg.2019.103257DOI Listing
November 2019

Binary and ternary solid dispersions of an anticancer preclinical lead, IIIM-290: In vitro and in vivo studies.

Int J Pharm 2019 Oct 9;570:118683. Epub 2019 Sep 9.

Preformulation Laboratory, PK-PD Toxicology and Formulation Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu 180001, India. Electronic address:

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http://dx.doi.org/10.1016/j.ijpharm.2019.118683DOI Listing
October 2019

Isolation of depsipeptides and optimization for enhanced production of valinomycin from the North-Western Himalayan cold desert strain Streptomyces lavendulae.

J Antibiot (Tokyo) 2019 08 9;72(8):617-624. Epub 2019 May 9.

Medicinal Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu, 180001, India.

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http://dx.doi.org/10.1038/s41429-019-0183-yDOI Listing
August 2019

Design, synthesis and biological evaluation of pyrazolopyrimidinone based potent and selective PDE5 inhibitors for treatment of erectile dysfunction.

Bioorg Chem 2019 Aug 31;89:103022. Epub 2019 May 31.

Medicinal Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu 180 001, India; Academy of Scientific and Innovative Research, Anusandhan Bhawan, 2 Rafi Marg, New Delhi 110 001, India. Electronic address:

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http://dx.doi.org/10.1016/j.bioorg.2019.103022DOI Listing
August 2019

Glycyrrhizic Acid Prevents Oxidative Stress Mediated DNA Damage Response through Modulation of Autophagy in Ultraviolet-B-Irradiated Human Primary Dermal Fibroblasts.

Cell Physiol Biochem 2019 ;53(1):242-257

Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, Uttar Pradesh, Jammu Campus, CSIR-Indian Institute of Integrative Medicine, Jammu Tawi, Jammu and Kashmir, India.

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http://dx.doi.org/10.33594/000000133DOI Listing
July 2019

Transformation of Santonin to a Naproxen Analogue with Anti-Inflammatory Activity.

J Nat Prod 2019 06 24;82(6):1710-1713. Epub 2019 May 24.

Medicinal Chemistry Division and Natural Product Chemistry Division , Indian Institute of Integrative Medicine (CSIR) , Canal Road , Jammu - 180001 , India.

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http://pubs.acs.org/doi/10.1021/acs.jnatprod.8b00318
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http://dx.doi.org/10.1021/acs.jnatprod.8b00318DOI Listing
June 2019

Analyzing the role of cannabinoids as modulators of Wnt/β-catenin signaling pathway for their use in the management of neuropathic pain.

Bioorg Med Chem Lett 2019 05 11;29(9):1043-1046. Epub 2019 Mar 11.

Natural Product Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu 180001, India; Academy of Scientific and Innovative Research, New Delhi, India. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2019.03.013DOI Listing
May 2019

Discovery and preclinical development of IIIM-160, a Bergenia ciliata-based anti-inflammatory and anti-arthritic botanical drug candidate.

J Integr Med 2019 May 6;17(3):192-204. Epub 2019 Mar 6.

Medicinal Chemistry Division, Indian Institute of Integrative Medicine (Council of Scientific and Industrial Research), Jammu 180001, India.

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https://linkinghub.elsevier.com/retrieve/pii/S20954964193002
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http://dx.doi.org/10.1016/j.joim.2019.03.001DOI Listing
May 2019

Introducing Oxo-Phenylacetyl (OPAc) as a Protecting Group for Carbohydrates.

J Org Chem 2019 04 28;84(7):4131-4148. Epub 2019 Mar 28.

Medicinal Chemistry Division , Indian Institute of Integrative Medicine (IIIM) , Jammu 180001 , India.

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http://dx.doi.org/10.1021/acs.joc.9b00126DOI Listing
April 2019

Impurity profiling of anticancer preclinical candidate, IIIM-290.

J Pharm Biomed Anal 2019 Mar 18;166:1-5. Epub 2018 Dec 18.

Preformulation Laboratory, PK-PD Toxicology and Formulation Division, CSIR- Indian Institute of Integrative Medicine, Canal Road, Jammu, 180001, India. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S07317085183219
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http://dx.doi.org/10.1016/j.jpba.2018.12.027DOI Listing
March 2019

Why Are the Majority of Active Compounds in the CNS Domain Natural Products? A Critical Analysis.

J Med Chem 2018 12 20;61(23):10345-10374. Epub 2018 Jul 20.

Medicinal Chemistry Division , CSIR-Indian Institute of Integrative Medicine , Canal Road , Jammu 180001 , India.

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http://dx.doi.org/10.1021/acs.jmedchem.7b01922DOI Listing
December 2018

Orally Effective Aminoalkyl 10H-Indolo[3,2-b]quinoline-11-carboxamide Kills the Malaria Parasite by Inhibiting Host Hemoglobin Uptake.

ChemMedChem 2018 12 13;13(23):2581-2598. Epub 2018 Nov 13.

CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu, 180001, India.

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http://doi.wiley.com/10.1002/cmdc.201800579
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http://dx.doi.org/10.1002/cmdc.201800579DOI Listing
December 2018

Soluble Aβ suppresses TNF-α and activates NLRP3 inflammasome in THP-1 macrophages.

Cytokine 2018 11 17;111:84-87. Epub 2018 Aug 17.

Division of PK-PD-Toxicology and Formulation Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu 180001, India; Academy of Scientific and Innovative Research (AcSIR), New Delhi, India. Electronic address:

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http://dx.doi.org/10.1016/j.cyto.2018.07.026DOI Listing
November 2018

Room Temperature Metal-Catalyzed Oxidative Acylation of Electron-Deficient Heteroarenes with Alkynes, Its Mechanism, and Application Studies.

J Org Chem 2018 Oct 9;83(20):12420-12431. Epub 2018 Oct 9.

Medicinal Chemistry Division , Academy of Scientific and Innovative Research, CSIR-Indian Institute of Integrative Medicine , Canal Road , Jammu 180001 , India.

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http://pubs.acs.org/doi/10.1021/acs.joc.8b01475
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http://dx.doi.org/10.1021/acs.joc.8b01475DOI Listing
October 2018

Preclinical Development of -Based Botanical Lead IIIM-141 for Alzheimer's Disease: Chemical Standardization, Efficacy, Formulation Development, Pharmacokinetics, and Safety Pharmacology.

ACS Omega 2018 Aug 20;3(8):9572-9585. Epub 2018 Aug 20.

Preformulaion Laboratory, PK-PD Toxicology and Formulation Division, Academy of Scientific & Innovative Research, PK-PD Toxicology and Formulation Division, QC-QA Division, and Medicinal Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu 180001, India.

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http://dx.doi.org/10.1021/acsomega.8b00841DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6644748PMC
August 2018

Porostereum sp., Associated with Saffron (Crocus sativus L.), is a Latent Pathogen Capable of Producing Phytotoxic Chlorinated Aromatic Compounds.

Curr Microbiol 2018 Jul 28;75(7):880-887. Epub 2018 Feb 28.

Microbial Biotechnology Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu Tawi, 180001, India.

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http://dx.doi.org/10.1007/s00284-018-1461-9DOI Listing
July 2018

Selection of a Water-Soluble Salt Form of a Preclinical Candidate, IIIM-290: Multiwell-Plate Salt Screening and Characterization.

ACS Omega 2018 Jul 27;3(7):8365-8377. Epub 2018 Jul 27.

Preformulation Laboratory, PK-PD Toxicology and Formulation Division, Medicinal Chemistry Division, and Academy of Scientific & Innovative Research, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu 180001, India.

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http://pubs.acs.org/doi/10.1021/acsomega.8b00801
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http://dx.doi.org/10.1021/acsomega.8b00801DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6072253PMC
July 2018

Design and synthesis of 1,4-substituted 1H-1,2,3-triazolo-quinazolin-4(3H)-ones by Huisgen 1,3-dipolar cycloaddition with PI3Kγ isoform selective activity.

Bioorg Med Chem Lett 2018 04 16;28(6):1005-1010. Epub 2018 Feb 16.

Medicinal Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu 180 001, India; Academy of Scientific and Innovative Research, Anusandhan Bhawan, 2 Rafi Marg, New Delhi 110 001, India. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2018.02.032DOI Listing
April 2018

Establishment of LCMS Based Platform for Discovery of Quorum Sensing Inhibitors: Signal Detection in Pseudomonas aeruginosa PAO1.

ACS Chem Biol 2018 03 18;13(3):657-665. Epub 2018 Jan 18.

Medicinal Chemistry Division , Indian Institute of Integrative Medicine (CSIR) , Canal Road , Jammu - 180001 , India.

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http://dx.doi.org/10.1021/acschembio.7b00875DOI Listing
March 2018

Present drug-likeness filters in medicinal chemistry during the hit and lead optimization process: how far can they be simplified?

Drug Discov Today 2018 03 9;23(3):605-615. Epub 2018 Jan 9.

Medicinal Chemistry Division, Indian Institute of Integrative Medicine (Council of Scientific and Industrial Research), Canal Road, Jammu 180001, India. Electronic address:

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http://dx.doi.org/10.1016/j.drudis.2018.01.010DOI Listing
March 2018

Discovery and Preclinical Development of IIIM-290, an Orally Active Potent Cyclin-Dependent Kinase Inhibitor.

J Med Chem 2018 02 6;61(4):1664-1687. Epub 2018 Feb 6.

Medicinal Chemistry Division, CSIR-Indian Institute of Integrative Medicine , Canal Road, Jammu-180001, India.

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http://dx.doi.org/10.1021/acs.jmedchem.7b01765DOI Listing
February 2018

Lipovelutibols A-D: Cytotoxic Lipopeptaibols from the Himalayan Cold Habitat Fungus Trichoderma velutinum.

J Nat Prod 2018 02 26;81(2):219-226. Epub 2018 Jan 26.

Medicinal Chemistry Division, CSIR-Indian Institute of Integrative Medicine , Canal Road, Jammu 180 001, India.

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http://dx.doi.org/10.1021/acs.jnatprod.6b00873DOI Listing
February 2018

Corrigendum: Mannitol Stress Directs Flavonoid Metabolism toward Synthesis of Flavones via Differential Regulation of Two Cytochrome P450 Monooxygenases in .

Front Plant Sci 2017;8:2222. Epub 2018 Jan 8.

Indian Institute of Integrative Medicine (CSIR-IIIM), Council of Scientific and Industrial Research, Jammu, India.

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http://dx.doi.org/10.3389/fpls.2017.02222DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5767082PMC
January 2018

Glycyrrhiza glabra extract and quercetin reverses cisplatin resistance in triple-negative MDA-MB-468 breast cancer cells via inhibition of cytochrome P450 1B1 enzyme.

Bioorg Med Chem Lett 2017 12 7;27(24):5400-5403. Epub 2017 Nov 7.

Academy of Scientific & Innovative Research (AcSIR), CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu 180001, India; Medicinal Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu 180001, India. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2017.11.013DOI Listing
December 2017

Synthesis, pH dependent, plasma and enzymatic stability of bergenin prodrugs for potential use against rheumatoid arthritis.

Bioorg Med Chem 2017 10 10;25(20):5513-5521. Epub 2017 Aug 10.

Academy of Scientific and Innovative Research (AcSIR), CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu 180001, India; Medicinal Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu 180001, India. Electronic address:

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http://dx.doi.org/10.1016/j.bmc.2017.08.011DOI Listing
October 2017

Chemical chaperone 4-phenyl butyric acid (4-PBA) reduces hepatocellular lipid accumulation and lipotoxicity through induction of autophagy.

J Lipid Res 2017 09 27;58(9):1855-1868. Epub 2017 Jun 27.

Academy of Scientific and Innovative Research, Jammu Campus, Council of Scientific and Industrial Research (CSIR)-Indian Institute of Integrative Medicine, Jammu Tawi, Jammu and Kashmir, India

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http://dx.doi.org/10.1194/jlr.M077537DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5580899PMC
September 2017

Natural alkaloids as P-gp inhibitors for multidrug resistance reversal in cancer.

Eur J Med Chem 2017 Sep 27;138:273-292. Epub 2017 Jun 27.

Medicinal Chemistry Division, CSIR - Indian Institute of Integrative Medicine, Canal Road, Jammu 180001, India; Academy and Scientific & Innovative Research (AcSIR), CSIR - Indian Institute of Integrative Medicine, Canal Road, Jammu 180001, India. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2017.06.047DOI Listing
September 2017

Determining Partition Coefficient (Log P), Distribution Coefficient (Log D) and Ionization Constant (pKa) in Early Drug Discovery.

Comb Chem High Throughput Screen 2016 ;19(6):461-9

Medicinal Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu-180001, India.

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http://dx.doi.org/10.2174/1386207319666160502123917DOI Listing
August 2017

Crocus sativus Extract Tightens the Blood-Brain Barrier, Reduces Amyloid β Load and Related Toxicity in 5XFAD Mice.

ACS Chem Neurosci 2017 08 15;8(8):1756-1766. Epub 2017 May 15.

Department of Basic Pharmaceutical Sciences, School of Pharmacy, University of Louisiana at Monroe , Monroe, Louisiana 71201, United States.

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http://pubs.acs.org/doi/10.1021/acschemneuro.7b00101
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http://dx.doi.org/10.1021/acschemneuro.7b00101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5559303PMC
August 2017

Development and validation of a highly sensitive LC-ESI-MS/MS method for estimation of IIIM-MCD-211, a novel nitrofuranyl methyl piperazine derivative with potential activity against tuberculosis: Application to drug development.

J Chromatogr B Analyt Technol Biomed Life Sci 2017 Aug 8;1060:200-206. Epub 2017 Jun 8.

PK-PD, Toxicology and Formulation division, CSIR- Indian Institute of Integrative Medicine, Jammu 180 001, India. Electronic address:

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http://dx.doi.org/10.1016/j.jchromb.2017.06.015DOI Listing
August 2017

Synthesis and biological evaluation of pyrrole-based chalcones as CYP1 enzyme inhibitors, for possible prevention of cancer and overcoming cisplatin resistance.

Bioorg Med Chem Lett 2017 08 4;27(16):3683-3687. Epub 2017 Jul 4.

Medicinal Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu 180001, India; Academy of Scientific & Innovative Research (AcSIR), CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu 180001, India. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2017.07.010DOI Listing
August 2017

Revelation and cloning of valinomycin synthetase genes in Streptomyces lavendulae ACR-DA1 and their expression analysis under different fermentation and elicitation conditions.

J Biotechnol 2017 Jul 18;253:40-47. Epub 2017 May 18.

CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu,180001, India; Academy of Scientific & Innovative Research, New Delhi, 110001, India. Electronic address:

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http://dx.doi.org/10.1016/j.jbiotec.2017.05.008DOI Listing
July 2017

(Z)-2-(3-Chlorobenzylidene)-3,4-dihydro-N-(2-methoxyethyl)-3-oxo-2H-benzo[b][1,4]oxazine-6-carboxamide as GSK-3β inhibitor: Identification by virtual screening and its validation in enzyme- and cell-based assay.

Chem Biol Drug Des 2017 06 16;89(6):964-971. Epub 2017 Feb 16.

Medicinal Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Jammu, India.

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http://dx.doi.org/10.1111/cbdd.12913DOI Listing
June 2017

Identification of Potent and Selective CYP1A1 Inhibitors via Combined Ligand and Structure-Based Virtual Screening and Their in Vitro Validation in Sacchrosomes and Live Human Cells.

J Chem Inf Model 2017 06 22;57(6):1309-1320. Epub 2017 May 22.

Medicinal Chemistry Division, Indian Institute of Integrative Medicine (CSIR) , Canal Road, Jammu-180001, India.

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http://dx.doi.org/10.1021/acs.jcim.7b00095DOI Listing
June 2017

Functional Characterization of BGlu12, a β-Glucosidase from , Provides Insights into Its Role in Abiotic Stress through Accumulation of Antioxidant Flavonols.

J Biol Chem 2017 03 31;292(11):4700-4713. Epub 2017 Jan 31.

From the Plant Biotechnology Division, Council of Scientific and Industrial Research-Indian Institute of Integrative Medicine, Sanat Nagar, Srinagar, Jammu and Kashmir 190005 and

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http://www.jbc.org/lookup/doi/10.1074/jbc.M116.762161
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http://dx.doi.org/10.1074/jbc.M116.762161DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5377784PMC
March 2017

Antidiabetic potential of polyherbal formulation DB14201: Preclinical development, safety and efficacy studies.

J Ethnopharmacol 2017 Feb 22;197:218-230. Epub 2016 Jul 22.

CSIR - Indian Institute of Integrative Medicine, Canal Road, Jammu 180001, India.

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http://dx.doi.org/10.1016/j.jep.2016.07.062DOI Listing
February 2017

Diapolic acid A-B from an endophytic fungus, Diaporthe terebinthifolii depicting antimicrobial and cytotoxic activity.

J Antibiot (Tokyo) 2017 02 7;70(2):212-215. Epub 2016 Sep 7.

Natural Products Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Jammu, India.

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http://dx.doi.org/10.1038/ja.2016.109DOI Listing
February 2017

Development and mechanistic insight into enhanced cytotoxic potential of hyaluronic acid conjugated nanoparticles in CD44 overexpressing cancer cells.

Eur J Pharm Sci 2017 Jan 29;97:79-91. Epub 2016 Oct 29.

Academy of Scientific and Innovative Research (AcSIR), Anusandhan Bhawan, 2 Rafi Marg, New Delhi 110001, India; Formulation & Drug Delivery Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu 180001, India. Electronic address:

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http://dx.doi.org/10.1016/j.ejps.2016.10.028DOI Listing
January 2017

Metal-free Cross-Dehydrogenative Coupling of HN-azoles with α-C(sp)-H Amides via C-H Activation and Its Mechanistic and Application Studies.

J Org Chem 2017 01 9;82(2):1000-1012. Epub 2017 Jan 9.

Medicinal Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Academy of Scientific and Innovative Research , Canal Road, Jammu 180001, India.

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http://pubs.acs.org/doi/10.1021/acs.joc.6b02448
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http://dx.doi.org/10.1021/acs.joc.6b02448DOI Listing
January 2017

Optimization of nonribosomal peptides production by a psychrotrophic fungus: Trichoderma velutinum ACR-P1.

Appl Microbiol Biotechnol 2016 Nov 10;100(21):9091-9102. Epub 2016 Jun 10.

Fermentation Technology Division, CSIR-Indian Institute of Integrative Medicine, Jammu, 180001, India.

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http://dx.doi.org/10.1007/s00253-016-7622-5DOI Listing
November 2016

Production of Gentisyl Alcohol from Phoma herbarum Endophytic in Curcuma longa L. and Its Antagonistic Activity Towards Leaf Spot Pathogen Colletotrichum gloeosporioides.

Appl Biochem Biotechnol 2016 Nov 11;180(6):1093-1109. Epub 2016 Jun 11.

Fungal Biotechnology Laboratory, School of Biotechnology, University of Jammu, Jammu, Jammu and Kashmir, 180006, India.

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http://dx.doi.org/10.1007/s12010-016-2154-0DOI Listing
November 2016

Preclinical comprehensive physicochemical and pharmacokinetic profiling of novel nitroimidazole derivative IIIM-019 - A potential oral treatment for tuberculosis.

Pulm Pharmacol Ther 2016 10 25;40:44-51. Epub 2016 Jul 25.

Inflammation Pharmacology Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu, 180001, J&K, India. Electronic address:

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http://dx.doi.org/10.1016/j.pupt.2016.06.009DOI Listing
October 2016

6-Aryl substituted 4-(4-cyanomethyl) phenylamino quinazolines as a new class of isoform-selective PI3K-alpha inhibitors.

Eur J Med Chem 2016 Oct 12;122:731-743. Epub 2016 Jul 12.

Medicinal Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu, 180001, India; Academy of Scientific & Innovative Research (AcSIR), CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu, 180001, India. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2016.07.006DOI Listing
October 2016

Functional induction of P-glycoprotein efflux pump by phenyl benzenesulfonamides: Synthesis and biological evaluation of T0901317 analogs.

Eur J Med Chem 2016 Oct 6;122:744-755. Epub 2016 Jul 6.

Medicinal Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu 180001, India; Academy of Scientific & Innovative Research (AcSIR), CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu 180001, India. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S02235234163055
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http://dx.doi.org/10.1016/j.ejmech.2016.07.005DOI Listing
October 2016

Modulating lipophilicity of rohitukine via prodrug approach: Preparation, characterization, and in vitro enzymatic hydrolysis in biorelevant media.

Eur J Pharm Sci 2016 Sep 12;92:203-11. Epub 2016 Jul 12.

Academy of Scientific and Innovative Research (AcSIR), CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu 180001, India; Medicinal Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu 180001, India. Electronic address:

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http://dx.doi.org/10.1016/j.ejps.2016.07.010DOI Listing
September 2016

A Novel Quinoline Based Second-generation mTOR Inhibitor that Induces Apoptosis and Disrupts PI3K-Akt-mTOR Signaling in Human Leukemia HL-60 Cells.

Anticancer Agents Med Chem 2015 ;15(10):1297-304

Senior Scientist, Division of Cancer Pharmacology, Indian Institute of Integrative Medicine, CSIR, Canal Road, Jammu, 180001 India.

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http://dx.doi.org/10.2174/1871520615666150402093558DOI Listing
August 2016

A chromatography-free isolation of rohitukine from leaves of Dysoxylum binectariferum: Evaluation for in vitro cytotoxicity, Cdk inhibition and physicochemical properties.

Bioorg Med Chem Lett 2016 08 16;26(15):3457-63. Epub 2016 Jun 16.

Academy of Scientific & Innovative Research (AcSIR), CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu 180001, India; Medicinal Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu 180001, India. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2016.06.046DOI Listing
August 2016

I2/Aqueous TBHP-Catalyzed Coupling of Amides with Methylarenes/Aldehydes/Alcohols: Metal-Free Synthesis of Imides.

Org Lett 2016 08 19;18(15):3638-41. Epub 2016 Jul 19.

Academy of Scientific and Innovative Research , Canal Road, Jammu 180001, India.

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http://pubs.acs.org/doi/10.1021/acs.orglett.6b01684
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http://dx.doi.org/10.1021/acs.orglett.6b01684DOI Listing
August 2016

Metal-Free, Phosphonium Salt-Mediated Sulfoximination of Azine N-Oxides: Approach for the Synthesis of N-Azine Sulfoximines.

J Org Chem 2016 07 6;81(14):5886-94. Epub 2016 Jul 6.

Medicinal Chemistry Division, Academy of Scientific and Innovative Research, CSIR-Indian Institute of Integrative Medicine , Canal Road, Jammu-180001, India.

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http://dx.doi.org/10.1021/acs.joc.6b00593DOI Listing
July 2016

Mannitol Stress Directs Flavonoid Metabolism toward Synthesis of Flavones via Differential Regulation of Two Cytochrome P450 Monooxygenases in Coleus forskohlii.

Front Plant Sci 2016 6;7:985. Epub 2016 Jul 6.

Indian Institute of Integrative Medicine (CSIR-IIIM), Council of Scientific and Industrial ResearchJammu, India; Division of Biological Science, Faculty of Science, Academy of Scientific and Innovative ResearchKolkata, India.

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http://dx.doi.org/10.3389/fpls.2016.00985DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4933719PMC
July 2016

Development and validation of a highly sensitive LC-MS/MS-ESI method for quantification of IIIM-019-A novel nitroimidazole derivative with promising action against Tuberculosis: Application to drug development.

J Pharm Biomed Anal 2016 May 22;124:26-33. Epub 2016 Feb 22.

Inflammation Pharmacology Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu 180001, J&K, India. Electronic address:

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http://dx.doi.org/10.1016/j.jpba.2016.02.027DOI Listing
May 2016

Metal free C-H functionalization of diazines and related heteroarenes with organoboron species and its application in the synthesis of a CDK inhibitor, meriolin 1.

Org Biomol Chem 2016 May 18;14(18):4312-20. Epub 2016 Apr 18.

Medicinal Chemistry Division, CSIR-Indian Institute of Integrative Medicine and Academy of Scientific and Innovative Research, Canal Road, Jammu 180001, India.

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http://dx.doi.org/10.1039/c6ob00526hDOI Listing
May 2016

Discovery of a marine-derived bis-indole alkaloid fascaplysin, as a new class of potent P-glycoprotein inducer and establishment of its structure-activity relationship.

Eur J Med Chem 2016 Jan 31;107:1-11. Epub 2015 Oct 31.

Medicinal Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu 180001, India; Academy of Scientific & Innovative Research (AcSIR), CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu 180001, India. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2015.10.049DOI Listing
January 2016

Metal-free oxidative cyclization of acetophenones with diamines: a facile access to phenylpyridines.

Chem Commun (Camb) 2016 Jan;52(5):1009-12

Medicinal Chemistry Division, CSIR - Indian Institute of Integrative Medicine, Canal Road, Jammu-180001, India. and Academy of Scientific & Innovative Research (AcSIR), CSIR - Indian Institute of Integrative Medicine, Canal Road, Jammu-180001, India.

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http://dx.doi.org/10.1039/c5cc08498aDOI Listing
January 2016

Cross-dehydrogenative coupling of α-C(sp(3))-H of ethers/alkanes with C(sp(2))-H of heteroarenes under metal-free conditions.

Org Biomol Chem 2015 Dec 30;13(46):11341-50. Epub 2015 Sep 30.

Medicinal Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu-180001, India.

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http://dx.doi.org/10.1039/c5ob01268fDOI Listing
December 2015

Dimethyltin Dichloride Catalyzed Regioselective Alkylation of cis-1,2-Diols at Room Temperature.

J Org Chem 2015 Dec 25;80(24):11916-25. Epub 2015 Nov 25.

Medicinal Chemistry Division, CSIR-Indian Institute of Integrative Medicine , Canal Road, Jammu 180 001, India.

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http://dx.doi.org/10.1021/acs.joc.5b01898DOI Listing
December 2015

Plant Omics: Isolation, Identification, and Expression Analysis of Cytochrome P450 Gene Sequences from Coleus forskohlii.

OMICS 2015 Dec;19(12):782-92

1 Indian Institute of Integrative Medicine (CSIR-IIIM) , Council of Scientific and Industrial Research, Jammu, India .

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http://www.liebertpub.com/doi/10.1089/omi.2015.0148
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December 2015

An efficient transformation of furano-hydroxychalcones to furanoflavones via base mediated intramolecular tandem O-arylation and C-O bond cleavage: a new approach for the synthesis of furanoflavones.

Org Biomol Chem 2015 Nov 1;13(42):10461-5. Epub 2015 Oct 1.

Natural Products Chemistry Division, CSIR-Indian Institute of Integrative Medicine (CSIR), Canal Road, Jammu 180001, India.

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http://dx.doi.org/10.1039/c5ob01802aDOI Listing
November 2015

Metal-Free Approach for the Synthesis of N-Aryl Sulfoximines via Aryne Intermediate.

Org Lett 2015 Nov 12;17(22):5547-9. Epub 2015 Nov 12.

Medicinal Chemistry Division, CSIR-Indian Institute of Integrative Medicine , Canal Road, Jammu-180001, India.

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http://pubs.acs.org/doi/10.1021/acs.orglett.5b02804
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http://dx.doi.org/10.1021/acs.orglett.5b02804DOI Listing
November 2015

An endophyte of Picrorhiza kurroa Royle ex. Benth, producing menthol, phenylethyl alcohol and 3-hydroxypropionic acid, and other volatile organic compounds.

World J Microbiol Biotechnol 2015 Oct 29;31(10):1647-54. Epub 2015 Jul 29.

Microbial Biotechnology Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu Tawi, Jammu, 180 001, India.

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http://dx.doi.org/10.1007/s11274-015-1910-6DOI Listing
October 2015

Nitrofuranyl Methyl Piperazines as New Anti-TB Agents: Identification, Validation, Medicinal Chemistry, and PK Studies.

ACS Med Chem Lett 2015 Oct 31;6(10):1041-6. Epub 2015 Aug 31.

Medicinal Chemistry Division, Clinical Microbiology Division, PK-PD and Toxicology Division, Pre-formulation Laboratory, Academy of Scientific and Innovative Research, CSIR-Indian Institute of Integrative Medicine , Canal Road, Jammu 180 001, India.

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http://dx.doi.org/10.1021/acsmedchemlett.5b00141DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4601053PMC
October 2015

Synthesis and Biological Evaluation of Polar Functionalities Containing Nitrodihydroimidazooxazoles as Anti-TB Agents.

ACS Med Chem Lett 2015 Oct 11;6(10):1059-64. Epub 2015 Sep 11.

Medicinal Chemistry Division, Academy of Scientific and Innovative Research, Clinical Microbiology, PK-PD and Toxicology Division, and Preformulation Laboratory, CSIR-Indian Institute of Integrative Medicine , Canal Road, Jammu 180 001, India.

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http://dx.doi.org/10.1021/acsmedchemlett.5b00202DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4601052PMC
October 2015

Simultaneous Quantification of Five Bioactive Flavonoids in High Altitude Plant Actinocarya tibetica by LC-ESI-MS/MS.

J AOAC Int 2015 Jul-Aug;98(4):907-12

Indian Institute of Integrative Medicine (CSIR), Natural Products Chemistry Division, Jammu-180001, India.

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http://dx.doi.org/10.5740/jaoacint.14-270DOI Listing
September 2015

Meridianin derivatives as potent Dyrk1A inhibitors and neuroprotective agents.

Bioorg Med Chem Lett 2015 Aug 21;25(15):2948-52. Epub 2015 May 21.

Medicinal Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu 180001, India; Academy of Scientific & Innovative Research (AcSIR), CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu 180001, India. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2015.05.034DOI Listing
August 2015

DMSO/I2 mediated C-C bond cleavage of α-ketoaldehydes followed by C-O bond formation: a metal-free approach for one-pot esterification.

Org Biomol Chem 2015 Aug 25;13(29):7973-8. Epub 2015 Jun 25.

Medicinal Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu-180 001, India.

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http://dx.doi.org/10.1039/c5ob01015bDOI Listing
August 2015

4-(N-Phenyl-N'-substituted benzenesulfonyl)-6-(4-hydroxyphenyl)quinolines as inhibitors of mammalian target of rapamycin.

Bioorg Med Chem 2015 Aug 26;23(15):4237-47. Epub 2015 Jun 26.

Medicinal Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu 180 001, India; Academy of Scientific and Innovative Research, Anusandhan Bhawan, 2 Rafi Marg, New Delhi 110 001, India. Electronic address:

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http://dx.doi.org/10.1016/j.bmc.2015.06.046DOI Listing
August 2015

Design, synthesis and anticancer activity of Michael-type thiol adducts of α-santonin analogue with exocyclic methylene.

Eur J Med Chem 2015 Aug 17;101:769-79. Epub 2015 Jul 17.

Department of Chemistry, University of Pretoria, Pretoria 0028, South Africa. Electronic address:

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http://dx.doi.org/10.1016/j.ejmech.2015.07.022DOI Listing
August 2015

CuBr catalyzed aerobic oxidative coupling of 2-aminopyridines with cinnamaldehydes: direct access to 3-formyl-2-phenyl-imidazo[1,2-a]pyridines.

Org Biomol Chem 2015 Jul 23;13(28):7790-4. Epub 2015 Jun 23.

Medicinal Chemistry Division, CSIR - Indian Institute of Integrative Medicine, Canal Road, Jammu 180001, India.

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http://dx.doi.org/10.1039/c5ob00776cDOI Listing
July 2015

Fascaplysin induces caspase mediated crosstalk between apoptosis and autophagy through the inhibition of PI3K/AKT/mTOR signaling cascade in human leukemia HL-60 cells.

J Cell Biochem 2015 Jun;116(6):985-97

Academy of Scientific and Innovative Research (AcSIR), New Delhi, 110001, India; Cancer Pharmacology Division, Indian Institute of Integrative Medicine, CSIR, Jammu, 180001, India.

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http://dx.doi.org/10.1002/jcb.25053DOI Listing
June 2015

Synthesis, antimalarial and antitubercular activities of meridianin derivatives.

Eur J Med Chem 2015 Jun 15;98:160-9. Epub 2015 May 15.

Medicinal Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu 180001, India; Academy of Scientific & Innovative Research (AcSIR), CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu 180001, India. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S02235234153004
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http://dx.doi.org/10.1016/j.ejmech.2015.05.020DOI Listing
June 2015

Discovery of novel pyrazolopyrimidinone analogs as potent inhibitors of phosphodiesterase type-5.

Bioorg Med Chem 2015 May 9;23(9):2121-8. Epub 2015 Mar 9.

Pharmacology Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu 180 001, India. Electronic address:

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http://dx.doi.org/10.1016/j.bmc.2015.03.005DOI Listing
May 2015

Cobalt(II) catalyzed C(sp)-H bond functionalization of alkynes with phenyl hydrazines: facile access to diaryl 1,2-diketones.

Org Biomol Chem 2015 May;13(18):5235-42

Medicinal Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu-180001, India.

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http://dx.doi.org/10.1039/c5ob00419eDOI Listing
May 2015

Discovery of 4-acetyl-3-(4-fluorophenyl)-1-(p-tolyl)-5-methylpyrrole as a dual inhibitor of human P-glycoprotein and Staphylococcus aureus Nor A efflux pump.

Org Biomol Chem 2015 May;13(19):5424-31

Medicinal Chemistry Division, CSIR - Indian Institute of Integrative Medicine, Canal Road, Jammu-180001, India.

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http://dx.doi.org/10.1039/c5ob00246jDOI Listing
May 2015

Synthesis and P-glycoprotein induction activity of colupulone analogs.

Org Biomol Chem 2015 May;13(19):5488-96

Medicinal Chemistry Division, CSIR-Indian Institute of Integrative Medicine (CSIR), Canal Road, Jammu-180001, India.

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http://dx.doi.org/10.1039/c5ob00554jDOI Listing
May 2015

Thermodynamic equilibrium solubility measurements in simulated fluids by 96-well plate method in early drug discovery.

Bioorg Med Chem Lett 2015 Apr 16;25(7):1561-7. Epub 2015 Feb 16.

Medicinal Chemistry Division, CSIR-Indian Institute of Integrative Medicine, Canal Road, Jammu 180001, India. Electronic address:

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http://dx.doi.org/10.1016/j.bmcl.2015.02.013DOI Listing
April 2015

3-(Benzo[d][1,3]dioxol-5-ylamino)-N-(4-fluorophenyl)thiophene-2-carboxamide overcomes cancer chemoresistance via inhibition of angiogenesis and P-glycoprotein efflux pump activity.

Org Biomol Chem 2015 Apr 11;13(14):4296-309. Epub 2015 Mar 11.

Medicinal Chemistry Division, CSIR-Indian Institute of Integrative Medicine (CSIR), Canal Road, Jammu-180001, India.

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http://dx.doi.org/10.1039/c5ob00233hDOI Listing
April 2015

Transbilayer lipid interactions mediate nanoclustering of lipid-anchored proteins.

Cell 2015 Apr;161(3):581-594

National Centre for Biological Sciences (TIFR), Bellary Road, Bangalore 560 065, India; Institute for Stem Cell Biology and Regenerative Medicine, Bellary Road, Bangalore 560 065, India. Electronic address:

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http://dx.doi.org/10.1016/j.cell.2015.03.048DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4651428PMC
April 2015

Molecular cloning and functional characterization of an antifungal PR-5 protein from Ocimum basilicum.

Gene 2015 Mar 27;558(1):143-51. Epub 2014 Dec 27.

CSIR-Indian Institute of Integrative Medicine (CSIR-IIIM), Canal Road, Jammu 180001, India; Academy of Scientific and Innovative Research, Council of Scientific & Industrial Research, Canal Road, Jammu 180001, India. Electronic address:

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http://dx.doi.org/10.1016/j.gene.2014.12.055DOI Listing
March 2015

Aminocatalytic cross-coupling approach via iminium ions to different C - C Bonds.

Chemistry 2015 Feb 18;21(7):2954-60. Epub 2014 Dec 18.

Medicinal Chemistry Division, Indian Institute of Integrative Medicine (IIIM), Jammu (India); Academey of Scientific and Innovative Research, 2-Rafi Marg, New Delhi (India).

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http://dx.doi.org/10.1002/chem.201405477DOI Listing
February 2015

Cross-dehydrogenative coupling of azoles with α-C(sp3)-H of ethers and thioethers under metal-free conditions: functionalization of H-N azoles via C-H activation.

J Org Chem 2015 Feb 28;80(3):1929-36. Epub 2015 Jan 28.

Medicinal Chemistry Division, CSIR-Indian Institute of Integrative Medicine , Canal Road, Jammu-18001, India.

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http://dx.doi.org/10.1021/jo502477rDOI Listing
February 2015

Identification, cloning and characterization of an ultrapetala transcription factor CsULT1 from Crocus: a novel regulator of apocarotenoid biosynthesis.

BMC Plant Biol 2015 Feb 1;15:25. Epub 2015 Feb 1.

Medicinal Chemisrty Division, CSIR- Indian Institute of Integrative Medicine, Canal Road, Jammu, J&K 180001, India.

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http://dx.doi.org/10.1186/s12870-015-0423-7DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4349709PMC
February 2015