Publications by authors named "Ralph W Yarnell"

2 Publications

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Physician Wellness and Practice Sustainability.

Int Anesthesiol Clin 2019 ;57(1):95-113

Department of Anesthesiology, The Larner College of Medicine at the University of Vermont, Burlington, Vermont.

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http://dx.doi.org/10.1097/AIA.0000000000000212DOI Listing
January 2020

Cell-free fetal DNA in the cerebrospinal fluid of women during the peripartum period.

Am J Obstet Gynecol 2004 Apr;190(4):1087-90

Division of Genetics Medicine, Department of Pediatrics, Tufts-New England Medical Center, Boston, MA 02111, USA.

Objective: The purpose of this study was to determine whether cell-free fetal DNA is detectable in the cerebrospinal fluid of women during pregnancy and after delivery.

Study Design: Cerebrospinal fluid was collected from 39 women who underwent an indicated spinal anesthesia procedure. Twenty-six samples were from women who carried at least 1 male fetus, and 13 samples were from women with only a female fetus. DNA was analyzed with the use of real-time polymerase chain reaction for DYS-1 (which represented male fetal DNA) and beta-globin (which represented maternal and fetal DNA).

Results: beta-Globin DNA was detected in all cerebrospinal samples. DYS-1 gene sequences were detected in 4 cerebrospinal fluid samples from women who had male fetuses (2 samples were from women who underwent cesarean delivery of singleton pregnancies, 1 sample was from a triplet pregnancy, and 1 sample was from a woman after delivery). No male DNA was detected in the cerebrospinal fluid of women who carried female fetuses.

Conclusion: Male fetal cells and/or cell-free fetal DNA is detectable in the cerebrospinal fluid of some pregnant women or some women after delivery.
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http://dx.doi.org/10.1016/j.ajog.2003.10.562DOI Listing
April 2004