Ralph V Shohet

Ralph V Shohet

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Ralph V Shohet

Ralph V Shohet

Publications by authors named "Ralph V Shohet"

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Protein kinase C binding protein 1 inhibits hypoxia-inducible factor-1 in the heart.

Cardiovasc Res 2019 Jul;115(8):1332-1342

Department of Medicine, Center for Cardiovascular Research, John A. Burns School of Medicine, University of Hawaii, BSB311H, 651 Ilalo St., Honolulu, USA.

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https://academic.oup.com/cardiovascres/advance-article/doi/1
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http://dx.doi.org/10.1093/cvr/cvy278DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6587917PMC
July 2019

Gender Differences in the Rate of 30-Day Readmissions after Percutaneous Coronary Intervention for Acute Coronary Syndrome.

Womens Health Issues 2019 Jan - Feb;29(1):17-22. Epub 2018 Oct 25.

Department of Medicine, John A. Burns School of Medicine, University of Hawaii, Honolulu, Hawaii; The Queen's Medical Center, Honolulu, Hawaii.

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http://dx.doi.org/10.1016/j.whi.2018.09.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6296765PMC
April 2019

HIF-1 regulation of miR-29c impairs SERCA2 expression and cardiac contractility.

Am J Physiol Heart Circ Physiol 2019 Mar 21;316(3):H554-H565. Epub 2018 Dec 21.

Center for Cardiovascular Research, John A. Burns School of Medicine, University of Hawaii , Honolulu, Hawaii.

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http://dx.doi.org/10.1152/ajpheart.00617.2018DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6459310PMC
March 2019

Sex influences susceptibility to methamphetamine cardiomyopathy in mice.

Physiol Rep 2019 Mar;7(6):e14036

Department of Medicine, University of Hawaii John A. Burns School of Medicine, Honolulu, Hawaii.

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http://dx.doi.org/10.14814/phy2.14036DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6424857PMC
March 2019

HIF1 mediates a switch in pyruvate kinase isoforms after myocardial infarction.

Physiol Genomics 2018 07 13;50(7):479-494. Epub 2018 Apr 13.

Center for Cardiovascular Research, John A. Burns School of Medicine, University of Hawaii , Honolulu, Hawaii.

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http://dx.doi.org/10.1152/physiolgenomics.00130.2017DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6087881PMC
July 2018

Study design and rationale to assess Doxycycline Efficacy in preventing coronary Artery Lesions in children with Kawasaki disease (DEAL trial) - A phase II clinical trial.

Contemp Clin Trials 2018 02 5;65:33-38. Epub 2017 Dec 5.

Kapi'olani Medical Specialists, Hawai'i Pacific Health, Honolulu, HI, United States; Department of Pediatrics, John A. Burns School of Medicine, University of Hawai'i, Honolulu, HI, United States.

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http://dx.doi.org/10.1016/j.cct.2017.11.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5803379PMC
February 2018

Associations of Age and Sex With Marfan Phenotype: The National Heart, Lung, and Blood Institute GenTAC (Genetically Triggered Thoracic Aortic Aneurysms and Cardiovascular Conditions) Registry.

Circ Cardiovasc Genet 2017 Jun;10(3)

From the Division of Cardiology, Weill Cornell Medicine, New York, NY (M.J.R., R.B.D., J.W.W.); Biostatistics and Epidemiology Division, RTI International, Rockville, MD (L.R.P.); MedStar Cardiovascular Research Network, Washington, DC (F.M.A.); Division of Cardiology, University of Michigan Health System, Ann Arbor (K.A.E.); Department of Pediatrics (K.W.H.), Division of Cardiothoracic Surgery (H.K.S.), and Knight Cardiovascular Institute (C.L.M.), Oregon Health & Science University, Portland; Division of Cardiothoracic Surgery (S.A.L.) and Division of Pediatric Cardiology, Department of Pediatrics (S.A.M.), Baylor College of Medicine, Houston, TX; Department of Cardiovascular Surgery, Texas Heart Institute, Houston (S.A.L.); Department of Internal Medicine, McGovern Medical School, University of Texas Health Science Center, San Antonio (D.M.M., S.K.P.); Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia (R.E.P.); Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD (W.J.R.); and Department of Medicine, John A. Burns School of Medicine, Honolulu, HI (R.V.S.).

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http://dx.doi.org/10.1161/CIRCGENETICS.116.001647DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5500868PMC
June 2017

The Cost-Benefit Balance of Statins in Hawai'i: A Moving Target.

Hawaii J Med Public Health 2017 04;76(4):99-102

Division of Cardiology, Department of Medicine, University of Hawai'i John A. Burns School of Medicine, Honolulu, HI (CJL, RVS, TBS).

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5395704PMC
April 2017

The TGF-β pathway mediates doxorubicin effects on cardiac endothelial cells.

J Mol Cell Cardiol 2016 Jan 11;90:129-38. Epub 2015 Dec 11.

Division of Basic Sciences, Kansas City University, USA. Electronic address:

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http://dx.doi.org/10.1016/j.yjmcc.2015.12.010DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4718883PMC
January 2016

Galectin-3 deficiency exacerbates hyperglycemia and the endothelial response to diabetes.

Cardiovasc Diabetol 2015 Jun 6;14:73. Epub 2015 Jun 6.

Center for Cardiovascular Research and Department of Medicine, University of Hawaii John A. Burns School of Medicine, Honolulu, HI, USA.

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http://dx.doi.org/10.1186/s12933-015-0230-3DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4499178PMC
June 2015

HIF-1α in the heart: remodeling nucleotide metabolism.

J Mol Cell Cardiol 2015 May 11;82:194-200. Epub 2015 Feb 11.

Department of Biomedical Sciences, Quillen College of Medicine, East Tennessee State University, Johnson City, TN, USA. Electronic address:

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http://dx.doi.org/10.1016/j.yjmcc.2015.01.014DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4405794PMC
May 2015

Up-regulation of glycolytic metabolism is required for HIF1α-driven bone formation.

Proc Natl Acad Sci U S A 2014 Jun 27;111(23):8673-8. Epub 2014 May 27.

Departments of Orthopaedic Surgery,Medicine,Developmental Biology, Washington University School of Medicine, St. Louis, MO 63110; and

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http://dx.doi.org/10.1073/pnas.1324290111DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4060724PMC
June 2014

Ultrasound directs a transposase system for durable hepatic gene delivery in mice.

Ultrasound Med Biol 2013 Dec 11;39(12):2351-61. Epub 2013 Sep 11.

Department of Medicine, John A. Burns School of Medicine, Honolulu, HI 96813.

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http://dx.doi.org/10.1016/j.ultrasmedbio.2013.07.002DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3838570PMC
December 2013

Methamphetamine-associated cardiomyopathy.

Clin Cardiol 2013 Dec 27;36(12):737-42. Epub 2013 Aug 27.

John A. Burns School of Medicine University of Hawaii at Manoa Honolulu, Hawaii.

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http://dx.doi.org/10.1002/clc.22195DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4319790PMC
December 2013

Cardiac angiogenesis directed by stable Hypoxia Inducible Factor-1.

Vasc Cell 2013 Aug 29;5(1):15. Epub 2013 Aug 29.

Department of Medicine, University of Hawaii, Honolulu, HI 96813, USA.

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http://dx.doi.org/10.1186/2045-824X-5-15DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3766207PMC
August 2013

Mouse models and techniques for the isolation of the diabetic endothelium.

ISRN Endocrinol 2013 11;2013:165397. Epub 2013 Jun 11.

Center for Cardiovascular Research, University of Hawaii John A. Burns School of Medicine, Honolulu, HI 96813, USA ; Department of Cell and Molecular Biology, University of Hawaii John A. Burns School of Medicine, Honolulu, HI 96813, USA ; Department of Medicine, University of Hawaii John A. Burns School of Medicine, 651 Ilalo Street, Honolulu, HI 96813, USA.

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http://dx.doi.org/10.1155/2013/165397DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3693106PMC
July 2013

Cubozoan venom-induced cardiovascular collapse is caused by hyperkalemia and prevented by zinc gluconate in mice.

PLoS One 2012 12;7(12):e51368. Epub 2012 Dec 12.

Department of Tropical Medicine, Medical Microbiology and Pharmacology, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, HI, USA.

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http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0051368PLOS
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3520902PMC
June 2013

Transcriptional analysis of the endothelial response to diabetes reveals a role for galectin-3.

Physiol Genomics 2011 Oct 26;43(20):1144-52. Epub 2011 Jul 26.

Center for Cardiovascular Research, University of Hawaii John A. Burns School of Medicine, Honolulu, Hawaii 96813, USA.

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http://dx.doi.org/10.1152/physiolgenomics.00035.2011DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3217326PMC
October 2011

Specific antioxidant selenoproteins are induced in the heart during hypertrophy.

Arch Biochem Biophys 2011 Aug 20;512(1):38-44. Epub 2011 May 20.

Department of Cell and Molecular Biology, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI 96813, USA.

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http://dx.doi.org/10.1016/j.abb.2011.05.007DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3129375PMC
August 2011

Introduction to the ultrasound targeted microbubble destruction technique.

J Vis Exp 2011 Jun 12(52). Epub 2011 Jun 12.

Department of Medicine, JABSOM, University of Hawaii, USA.

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http://dx.doi.org/10.3791/2963DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3197066PMC
June 2011

Hypercholesterolemia potentiates aortic endothelial response to inhaled diesel exhaust.

Inhal Toxicol 2011 Jan;23(1):1-10

Department of Medicine, University of Hawaii John A. Burns School of Medicine, Honolulu, HI 96813, USA.

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http://dx.doi.org/10.3109/08958378.2010.535572DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3606052PMC
January 2011

Tiny bubbles and endocytosis?

Circ Res 2009 Mar;104(5):563-5

Department of Medicine, University of Hawaii, Honolulu, HI 96813, USA.

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http://dx.doi.org/10.1161/CIRCRESAHA.109.195651DOI Listing
March 2009

Cardioprotective signaling by endothelin.

Trends Cardiovasc Med 2008 Oct;18(7):233-9

Department of Medicine, Center of Cardiovascular Research, John A Burns School of Medicine, University of Hawaii, Honolulu, HI 96813, USA.

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http://dx.doi.org/10.1016/j.tcm.2008.11.005DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4048746PMC
October 2008

In vivo endothelial gene regulation in diabetes.

Cardiovasc Diabetol 2008 Apr 19;7. Epub 2008 Apr 19.

Department of Medicine, University of Hawaii John A, Burns School of Medicine, Honolulu, USA.

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http://dx.doi.org/10.1186/1475-2840-7-8DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2365940PMC
April 2008

Down-regulation of caveolin-1, an inhibitor of transforming growth factor-beta signaling, in acute allergen-induced airway remodeling.

J Biol Chem 2008 Feb 3;283(9):5760-8. Epub 2007 Dec 3.

Department of Cell and Molecular Biology, John A. Burns School of Medicine, University of Hawaii, Honolulu, Hawaii 96813, USA.

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http://dx.doi.org/10.1074/jbc.M701572200DOI Listing
February 2008

Keeping the engine primed: HIF factors as key regulators of cardiac metabolism and angiogenesis during ischemia.

J Mol Med (Berl) 2007 Dec 20;85(12):1309-15. Epub 2007 Nov 20.

John A. Burns School of Medicine, Center for Cardiovascular Research, University of Hawaii, 651 Ilalo St., Honolulu, HI 96813, USA,

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http://dx.doi.org/10.1007/s00109-007-0279-xDOI Listing
December 2007

Broken heart syndrome--a critical review of transient left ventricular apical ballooning.

Hawaii Med J 2007 Oct;66(10):265-7

University of Hawai'i, John A. Burns School of Medicine, Honolulu, HI, USA.

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October 2007

Melatonin administration does not affect isoproterenol-induced LVH.

IEEE Eng Med Biol Mag 2006 May-Jun;25(3):84-7

University of Texas Southwestern Medical Center, Dallas 75390-8591, USA.

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November 2006

Endogenous endothelin-1 is required for cardiomyocyte survival in vivo.

Circulation 2006 Aug 14;114(8):830-7. Epub 2006 Aug 14.

Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA.

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http://dx.doi.org/10.1161/CIRCULATIONAHA.105.577288DOI Listing
August 2006

Efficient gene delivery to pancreatic islets with ultrasonic microbubble destruction technology.

Proc Natl Acad Sci U S A 2006 May 18;103(22):8469-74. Epub 2006 May 18.

Department of Internal Medicine, Cardiology Section, Baylor University Medical Center, Baylor Heart and Vascular Institute, 621 North Hall Street, Suite H030, Dallas, TX 75226, USA.

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http://dx.doi.org/10.1073/pnas.0602921103DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1482516PMC
May 2006

Potential bioeffects of ultrasonic destruction of microbubble contrast agents.

J Am Coll Cardiol 2006 Apr 15;47(7):1469-70. Epub 2006 Mar 15.

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http://dx.doi.org/10.1016/j.jacc.2006.01.033DOI Listing
April 2006

Transcriptional analysis of doxorubicin-induced cardiotoxicity.

Am J Physiol Heart Circ Physiol 2006 Mar 21;290(3):H1098-102. Epub 2005 Oct 21.

Department of Internal Medicine, Division of Cardiology, University of Texas Southwestern Medical Center at Dallas, USA.

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http://dx.doi.org/10.1152/ajpheart.00832.2005DOI Listing
March 2006

FcgammaRIIB mediates C-reactive protein inhibition of endothelial NO synthase.

Circ Res 2005 Nov 3;97(11):1124-31. Epub 2005 Nov 3.

Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX, USA.

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http://dx.doi.org/10.1161/01.RES.0000194323.77203.feDOI Listing
November 2005

Targeting vascular endothelium with avidin microbubbles.

Ultrasound Med Biol 2005 Sep;31(9):1279-83

Hamon Center for Therapeutic Oncology Research, Department of Surgery, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

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http://dx.doi.org/10.1016/j.ultrasmedbio.2005.06.001DOI Listing
September 2005

Tobacco smoke dysregulates endothelial vasoregulatory transcripts in vivo.

Physiol Genomics 2005 May 22;21(3):308-13. Epub 2005 Feb 22.

Department of Internal Medicine-Cardiology, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA

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http://dx.doi.org/10.1152/physiolgenomics.00310.2004DOI Listing
May 2005

Augmentation of cardiac protein delivery using ultrasound targeted microbubble destruction.

Ultrasound Med Biol 2005 May;31(5):687-91

Department of Internal Medicine, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, NB 11.200, Dallas, TX 75390-8573, USA.

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http://dx.doi.org/10.1016/j.ultrasmedbio.2004.08.002DOI Listing
May 2005

Use of ultrasound contrast agents for gene or drug delivery in cardiovascular medicine.

J Am Coll Cardiol 2005 Feb;45(3):329-35

Department of Internal Medicine, Division of Cardiology, University of Texas Southwestern Medical Center, Dallas, TX, USA.

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http://dx.doi.org/10.1016/j.jacc.2004.08.067DOI Listing
February 2005

Transcriptional analysis of mouse skeletal myofiber diversity and adaptation to endurance exercise.

J Muscle Res Cell Motil 2003 ;24(8):587-92

Department of Molecular Biology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390, USA.

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November 2004

In vivo transcriptional response of cardiac endothelium to lipopolysaccharide.

Arterioscler Thromb Vasc Biol 2004 Oct 19;24(10):1836-41. Epub 2004 Aug 19.

Internal Medicine-Cardiology, University of Texas Southwestern Medical Center, Dallas, Tex 75390-8573, USA.

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http://dx.doi.org/10.1161/01.ATV.0000143097.90868.c8DOI Listing
October 2004

Effects of ultrasound-targeted microbubble destruction on cardiac gene expression.

Ultrasound Med Biol 2004 Apr;30(4):539-43

Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.

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http://dx.doi.org/10.1016/j.ultrasmedbio.2003.12.006DOI Listing
April 2004

Cardiovascular gene therapy: angiogenesis and beyond.

Am J Med Sci 2004 Mar;327(3):139-48

Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA.

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http://dx.doi.org/10.1097/00000441-200403000-00005DOI Listing
March 2004

Mice with cardiomyocyte-specific disruption of the endothelin-1 gene are resistant to hyperthyroid cardiac hypertrophy.

Proc Natl Acad Sci U S A 2004 Feb 5;101(7):2088-93. Epub 2004 Feb 5.

Department of Internal Medicine, Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

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http://www.pnas.org/content/101/7/2088.full.pdf
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http://www.pnas.org/lookup/doi/10.1073/pnas.0307159101
Publisher Site
http://dx.doi.org/10.1073/pnas.0307159101DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC357056PMC
February 2004

Knowledge discovery by automated identification and ranking of implicit relationships.

Bioinformatics 2004 Feb 22;20(3):389-98. Epub 2004 Jan 22.

Advanced Center for Genome Technology, Department of Botany and Microbiology, The University of Oklahoma, 620 Parrington Oval Rm. 106, Norman, OK 73019, USA.

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http://dx.doi.org/10.1093/bioinformatics/btg421DOI Listing
February 2004

Ultrasound-targeted microbubble destruction can repeatedly direct highly specific plasmid expression to the heart.

Circulation 2003 Aug 11;108(8):1022-6. Epub 2003 Aug 11.

Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas 75390-8573, USA.

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http://dx.doi.org/10.1161/01.CIR.0000084535.35435.AEDOI Listing
August 2003

Optimization of ultrasound parameters for cardiac gene delivery of adenoviral or plasmid deoxyribonucleic acid by ultrasound-targeted microbubble destruction.

J Am Coll Cardiol 2003 Jul;42(2):301-8

Division of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical School, Dallas, Texas, USA.

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http://dx.doi.org/10.1016/s0735-1097(03)00627-2DOI Listing
July 2003

Transcriptional mapping and genomic analysis of the cardiac atria and ventricles.

Physiol Genomics 2002 Dec 26;12(1):53-60. Epub 2002 Dec 26.

Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390-8573, USA.

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http://dx.doi.org/10.1152/physiolgenomics.00086.2002DOI Listing
December 2002

Bioeffects of myocardial contrast microbubble destruction by echocardiography.

Echocardiography 2002 Aug;19(6):495-500

Departments of Internal Medicine (Cardiology Division) and Pathology, Dallas VA Medical Center, Dallas, Texas 75216, USA.

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August 2002

Analysis of the myoglobin gene in Tibetans living at high altitude.

High Alt Med Biol 2002 ;3(1):39-47

Women's Health Research Center, University of Colorado Health Sciences Center, Denver, CO 80262, USA.

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http://dx.doi.org/10.1089/152702902753639531DOI Listing
July 2002

DNA-loaded albumin microbubbles enhance ultrasound-mediated transfection in vitro.

Ultrasound Med Biol 2002 Jun;28(6):817-22

Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX, USA.

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http://dx.doi.org/10.1016/s0301-5629(02)00518-5DOI Listing
June 2002

Sources of variability in genetic association studies: insights from the analysis of hepatic lipase (LIPC).

Hum Mutat 2002 May;19(5):536-42

Internal Medicine, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas, USA.

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http://dx.doi.org/10.1002/humu.10079DOI Listing
May 2002