Publications by authors named "Ralph Tiedt"

32Publications

A Phase Ib/II, open-label, multicenter study of INC280 (capmatinib) alone and in combination with buparlisib (BKM120) in adult patients with recurrent glioblastoma.

J Neurooncol 2020 Jan 27;146(1):79-89. Epub 2019 Nov 27.

Clinical Cooperation Unit Neurooncology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), and Neurology Clinic and National Center for Tumor Diseases, University Hospital Heidelberg, Heidelberg, Germany.

View Article and Find Full Text PDF
January 2020

Targeting multiple nodes of MLL complexes to improve leukemia therapy.

Oncotarget 2017 Oct 7;8(53):90614-90615. Epub 2017 Oct 7.

Ralph Tiedt: Novartis Institutes for BioMedical Research, Disease Area Oncology, Basel, Switzerland.

View Article and Find Full Text PDF
October 2017

Project DRIVE: A Compendium of Cancer Dependencies and Synthetic Lethal Relationships Uncovered by Large-Scale, Deep RNAi Screening.

Cell 2017 Jul;170(3):577-592.e10

Novartis Institutes for Biomedical Research, Oncology Disease Area, Basel 4002, Switzerland; Cambridge, MA 02139, USA; and Emeryville, CA 94608, USA.

View Article and Find Full Text PDF
July 2017

Ratio of mutant JAK2-V617F to wild-type Jak2 determines the MPD phenotypes in transgenic mice.

Blood 2008 Apr 26;111(8):3931-40. Epub 2007 Dec 26.

Department of Research, Experimental Hematology, University Hospital Basel, Hebelstrasse 20, 4031 Basel, Switzerland.

View Article and Find Full Text PDF
April 2008

Pf4-Cre transgenic mice allow the generation of lineage-restricted gene knockouts for studying megakaryocyte and platelet function in vivo.

Blood 2007 Feb 10;109(4):1503-6. Epub 2006 Oct 10.

Department of Research and Experimental Hematology, University Hospital Basel, Switzerland.

View Article and Find Full Text PDF
February 2007

Altered gene expression in myeloproliferative disorders correlates with activation of signaling by the V617F mutation of Jak2.

Blood 2005 Nov 4;106(10):3374-6. Epub 2005 Aug 4.

Experimental Hematology, Department of Research, Division of Clinical Hematology, Division of Pneumology, Basel University Hospital, Switzerland.

View Article and Find Full Text PDF
November 2005

A gain-of-function mutation of JAK2 in myeloproliferative disorders.

N Engl J Med 2005 Apr;352(17):1779-90

Department of Research, Experimental Hematology, University Hospital Basel, Basel, Switzerland.

View Article and Find Full Text PDF
April 2005

Zim17, a novel zinc finger protein essential for protein import into mitochondria.

J Biol Chem 2004 Nov 21;279(48):50243-9. Epub 2004 Sep 21.

Russell Grimwade School of Biochemistry and Molecular Biology, University of Melbourne, Parkville 3010, Australia.

View Article and Find Full Text PDF
November 2004