Ralph Tiedt

Clinical Cooperation Unit Neurooncology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), and Neurology Clinic and National Center for Tumor Diseases, University Hospital Heidelberg, Heidelberg, Germany.

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January 2020

A conditional inducible JAK2V617F transgenic mouse model reveals myeloproliferative disease that is reversible upon switching off transgene expression.

PLoS One 2019 10;14(10):e0221635. Epub 2019 Oct 10.

Disease Area Oncology, Novartis Institutes for BioMedical Research, Basel, Switzerland.

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March 2020

Capmatinib (INC280) Is Active Against Models of Non-Small Cell Lung Cancer and Other Cancer Types with Defined Mechanisms of MET Activation.

Authors:

Sabrina Baltschukat Barbara Schacher Engstler Alan Huang Huai-Xiang Hao Angela Tam Hui Qin Wang Jinsheng Liang Matthew T DiMare Hyo-Eun Carrie Bhang Youzhen Wang Pascal Furet William R Sellers Francesco Hofmann Joseph Schoepfer Ralph Tiedt

Clin Cancer Res 2019 05 23;25(10):3164-3175. Epub 2019 Jan 23.

Novartis Institutes for BioMedical Research, Oncology Disease Area, Basel, Switzerland.

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May 2019

The potent and selective cyclin-dependent kinases 4 and 6 inhibitor ribociclib (LEE011) is a versatile combination partner in preclinical cancer models.

Authors:

Sunkyu Kim Ralph Tiedt Alice Loo Thomas Horn Scott Delach Steven Kovats Kristy Haas Barbara Schacher Engstler Alexander Cao Maria Pinzon-Ortiz Iain Mulford Michael G Acker Rajiv Chopra Christopher Brain Emmanuelle di Tomaso William R Sellers Giordano Caponigro

Oncotarget 2018 Oct 16;9(81):35226-35240. Epub 2018 Oct 16.

Novartis Institutes for BioMedical Research, Oncology Disease Area, Cambridge, MA, USA.

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October 2018

Targeting multiple nodes of MLL complexes to improve leukemia therapy.

Authors:

Caroline Dafflon Ralph Tiedt Jürg Schwaller

Oncotarget 2017 Oct 7;8(53):90614-90615. Epub 2017 Oct 7.

Ralph Tiedt: Novartis Institutes for BioMedical Research, Disease Area Oncology, Basel, Switzerland.

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October 2017

Project DRIVE: A Compendium of Cancer Dependencies and Synthetic Lethal Relationships Uncovered by Large-Scale, Deep RNAi Screening.

Authors:

E Robert McDonald Antoine de Weck Michael R Schlabach Eric Billy Konstantinos J Mavrakis Gregory R Hoffman Dhiren Belur Deborah Castelletti Elizabeth Frias Kalyani Gampa Javad Golji Iris Kao Li Li Philippe Megel Thomas A Perkins Nadire Ramadan David A Ruddy Serena J Silver Sosathya Sovath Mark Stump Odile Weber Roland Widmer Jianjun Yu Kristine Yu Yingzi Yue Dorothee Abramowski Elizabeth Ackley Rosemary Barrett Joel Berger Julie L Bernard Rebecca Billig Saskia M Brachmann Frank Buxton Roger Caothien Justina X Caushi Franklin S Chung Marta Cortés-Cros Rosalie S deBeaumont Clara Delaunay Aurore Desplat William Duong Donald A Dwoske Richard S Eldridge Ali Farsidjani Fei Feng JiaJia Feng Daisy Flemming William Forrester Giorgio G Galli Zhenhai Gao François Gauter Veronica Gibaja Kristy Haas Marc Hattenberger Tami Hood Kristen E Hurov Zainab Jagani Mathias Jenal Jennifer A Johnson Michael D Jones Avnish Kapoor Joshua Korn Jilin Liu Qiumei Liu Shumei Liu Yue Liu Alice T Loo Kaitlin J Macchi Typhaine Martin Gregory McAllister Amandine Meyer Sandra Mollé Raymond A Pagliarini Tanushree Phadke Brian Repko Tanja Schouwey Frances Shanahan Qiong Shen Christelle Stamm Christine Stephan Volker M Stucke Ralph Tiedt Malini Varadarajan Kavitha Venkatesan Alberto C Vitari Marco Wallroth Jan Weiler Jing Zhang Craig Mickanin Vic E Myer Jeffery A Porter Albert Lai Hans Bitter Emma Lees Nicholas Keen Audrey Kauffmann Frank Stegmeier Francesco Hofmann Tobias Schmelzle William R Sellers

Cell 2017 Jul;170(3):577-592.e10

Novartis Institutes for Biomedical Research, Oncology Disease Area, Basel 4002, Switzerland; Cambridge, MA 02139, USA; and Emeryville, CA 94608, USA.

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July 2017

Discovery of Potent, Selective, and Structurally Novel Dot1L Inhibitors by a Fragment Linking Approach.

Authors:

Henrik Möbitz Rainer Machauer Philipp Holzer Andrea Vaupel Frédéric Stauffer Christian Ragot Giorgio Caravatti Clemens Scheufler Cesar Fernandez Ulrich Hommel Ralph Tiedt Kim S Beyer Chao Chen Hugh Zhu Christoph Gaul

ACS Med Chem Lett 2017 Mar 14;8(3):338-343. Epub 2017 Feb 14.

Novartis Institutes for Biomedical Research , 4002 Basel, Switzerland.

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March 2017

Resistance mechanisms to TP53-MDM2 inhibition identified by in vivo piggyBac transposon mutagenesis screen in an Arf mouse model.

Proc Natl Acad Sci U S A 2017 03 6;114(12):3151-3156. Epub 2017 Mar 6.

Oncology Disease Area, Novartis Institutes for BioMedical Research, 4056 Basel, Switzerland.

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March 2017

Polyclonal Secondary Mutations Drive Acquired Resistance to FGFR Inhibition in Patients with FGFR2 Fusion-Positive Cholangiocarcinoma.

Cancer Discov 2017 03 29;7(3):252-263. Epub 2016 Dec 29.

Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts.

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March 2017

Discovery of Novel Dot1L Inhibitors through a Structure-Based Fragmentation Approach.

Authors:

Chao Chen Hugh Zhu Frédéric Stauffer Giorgio Caravatti Susanne Vollmer Rainer Machauer Philipp Holzer Henrik Möbitz Clemens Scheufler Martin Klumpp Ralph Tiedt Kim S Beyer Keith Calkins Daniel Guthy Michael Kiffe Jeff Zhang Christoph Gaul

ACS Med Chem Lett 2016 Aug 1;7(8):735-40. Epub 2016 Jun 1.

Novartis Institutes for Biomedical Research , 4002 Basel, Switzerland.

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August 2016

Optimization of a Fragment-Based Screening Hit toward Potent DOT1L Inhibitors Interacting in an Induced Binding Pocket.

Authors:

Clemens Scheufler Henrik Möbitz Christoph Gaul Christian Ragot Céline Be César Fernández Kim S Beyer Ralph Tiedt Frédéric Stauffer

ACS Med Chem Lett 2016 Aug 6;7(8):730-4. Epub 2016 Jun 6.

Novartis Institutes for Biomedical Research , 4002 Basel, Switzerland.

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August 2016

Rescue screens with secreted proteins reveal compensatory potential of receptor tyrosine kinases in driving cancer growth.

Cancer Discov 2012 Oct 8;2(10):948-59. Epub 2012 Aug 8.

Developmental and Molecular Pathways, Novartis Institutes for BioMedical Research, Cambridge, Massachusetts, USA.

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October 2012

Genetic resistance to JAK2 enzymatic inhibitors is overcome by HSP90 inhibition.

J Exp Med 2012 Feb 23;209(2):259-73. Epub 2012 Jan 23.

Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02115, USA.

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February 2012

A drug resistance screen using a selective MET inhibitor reveals a spectrum of mutations that partially overlap with activating mutations found in cancer patients.

Authors:

Ralph Tiedt Elisa Degenkolbe Pascal Furet Brent A Appleton Sabrina Wagner Joseph Schoepfer Emily Buck David A Ruddy John E Monahan Michael D Jones Jutta Blank Dorothea Haasen Peter Drueckes Markus Wartmann Clive McCarthy William R Sellers Francesco Hofmann

Cancer Res 2011 Aug 22;71(15):5255-64. Epub 2011 Jun 22.

Novartis Institutes for BioMedical Research, Basel, Switzerland.

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August 2011

Pronounced thrombocytosis in transgenic mice expressing reduced levels of Mpl in platelets and terminally differentiated megakaryocytes.

Authors:

Ralph Tiedt Jörn Coers Sandra Ziegler Adrian Wiestner Hui Hao-Shen Caroline Bornmann Johannes Schenkel Svetlana Karakhanova Frederic J de Sauvage Carl W Jackson Radek C Skoda

Blood 2009 Feb 9;113(8):1768-77. Epub 2008 Oct 9.

Department of Biomedicine, Experimental Hematology, University Hospital Basel, Basel, Switzerland.

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February 2009

A de novo splice donor mutation in the thrombopoietin gene causes hereditary thrombocythemia in a Polish family.

Authors:

Kun Liu Robert Kralovics Zbigniew Rudzki Barbara Grabowska Andreas S Buser Damla Olcaydu Heinz Gisslinger Ralph Tiedt Patricia Frank Krzysztof Okoñ Anthonie P C van der Maas Radek C Skoda

Haematologica 2008 May 26;93(5):706-14. Epub 2008 Mar 26.

Department of Biomedicine, Experimental Hematology, University Hospital Basel, Hebelstrasse 20, 4031 Basel, Switzerland.

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May 2008

Ratio of mutant JAK2-V617F to wild-type Jak2 determines the MPD phenotypes in transgenic mice.

Authors:

Ralph Tiedt Hui Hao-Shen Marta A Sobas Renate Looser Stephan Dirnhofer Jürg Schwaller Radek C Skoda

Blood 2008 Apr 26;111(8):3931-40. Epub 2007 Dec 26.

Department of Research, Experimental Hematology, University Hospital Basel, Hebelstrasse 20, 4031 Basel, Switzerland.

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April 2008

Talin is required for integrin-mediated platelet function in hemostasis and thrombosis.

Authors:

Brian G Petrich Patrizia Marchese Zaverio M Ruggeri Saskia Spiess Rachel A M Weichert Feng Ye Ralph Tiedt Radek C Skoda Susan J Monkley David R Critchley Mark H Ginsberg

J Exp Med 2007 Dec 17;204(13):3103-11. Epub 2007 Dec 17.

Department of Medicine, University of California, San Diego, La Jolla, CA 92093, USA.

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December 2007

Megakaryocyte-restricted MYH9 inactivation dramatically affects hemostasis while preserving platelet aggregation and secretion.

Authors:

Catherine Léon Anita Eckly Béatrice Hechler Boris Aleil Monique Freund Catherine Ravanat Marie Jourdain Christelle Nonne Josiane Weber Ralph Tiedt Marie-Pierre Gratacap Sonia Severin Jean-Pierre Cazenave François Lanza Radek Skoda Christian Gachet

Blood 2007 Nov 30;110(9):3183-91. Epub 2007 Jul 30.

INSERM U311, Etablissement Français du Sang-Alsace, 10 rue Spielmann, 67065 Strasbourg Cedex, France.

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November 2007

Pf4-Cre transgenic mice allow the generation of lineage-restricted gene knockouts for studying megakaryocyte and platelet function in vivo.

Authors:

Ralph Tiedt Tibor Schomber Hui Hao-Shen Radek C Skoda

Blood 2007 Feb 10;109(4):1503-6. Epub 2006 Oct 10.

Department of Research and Experimental Hematology, University Hospital Basel, Switzerland.

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February 2007

Altered gene expression in myeloproliferative disorders correlates with activation of signaling by the V617F mutation of Jak2.

Authors:

Robert Kralovics Soon-Siong Teo Andreas S Buser Martin Brutsche Ralph Tiedt Andre Tichelli Francesco Passamonti Daniela Pietra Mario Cazzola Radek C Skoda

Blood 2005 Nov 4;106(10):3374-6. Epub 2005 Aug 4.

Experimental Hematology, Department of Research, Division of Clinical Hematology, Division of Pneumology, Basel University Hospital, Switzerland.

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November 2005

A gain-of-function mutation of JAK2 in myeloproliferative disorders.

Authors:

Robert Kralovics Francesco Passamonti Andreas S Buser Soon-Siong Teo Ralph Tiedt Jakob R Passweg Andre Tichelli Mario Cazzola Radek C Skoda

N Engl J Med 2005 Apr;352(17):1779-90

Department of Research, Experimental Hematology, University Hospital Basel, Basel, Switzerland.

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April 2005

Zim17, a novel zinc finger protein essential for protein import into mitochondria.

Authors:

Lena Burri Katherine Vascotto Steffen Fredersdorf Ralph Tiedt Michael N Hall Trevor Lithgow

J Biol Chem 2004 Nov 21;279(48):50243-9. Epub 2004 Sep 21.

Russell Grimwade School of Biochemistry and Molecular Biology, University of Melbourne, Parkville 3010, Australia.

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November 2004

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