Publications by authors named "Ralph S Dacosta"

37Publications

Engineering functional microvessels in synthetic polyurethane random-pore scaffolds by harnessing perfusion flow.

Biomaterials 2020 Oct 23;256:120183. Epub 2020 Jun 23.

Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, Canada; Faculty of Dentistry, University of Toronto, Toronto, Canada. Electronic address:

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http://dx.doi.org/10.1016/j.biomaterials.2020.120183DOI Listing
October 2020

detection of porphyrin-producing wound bacteria with real-time fluorescence imaging.

Future Microbiol 2020 Mar 26;15:319-332. Epub 2020 Feb 26.

Department of Honors Studies, Texas Tech University, Lubbock, TX 79409, USA.

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http://dx.doi.org/10.2217/fmb-2019-0279DOI Listing
March 2020

Intravital Imaging for Tracking of Angiogenesis and Cellular Events Around Surgical Bone Implants.

Tissue Eng Part C Methods 2018 11 2;24(11):617-627. Epub 2018 Nov 2.

1 Faculty of Dentistry, University of Toronto , Toronto, Ontario, Canada .

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http://dx.doi.org/10.1089/ten.TEC.2018.0252DOI Listing
November 2018

Nanosurfaces modulate the mechanism of peri-implant endosseous healing by regulating neovascular morphogenesis.

Commun Biol 2018 18;1:72. Epub 2018 Jun 18.

Institute for Biomaterials and Biomedical Engineering, University of Toronto, Toronto, ON, M5G 1G6, Canada.

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http://dx.doi.org/10.1038/s42003-018-0074-yDOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6123776PMC
June 2018

The Necrosis-Avid Small Molecule HQ4-DTPA as a Multimodal Imaging Agent for Monitoring Radiation Therapy-Induced Tumor Cell Death.

Front Oncol 2016 21;6:221. Epub 2016 Oct 21.

Princess Margaret Cancer Center, University Health Network, Toronto, ON, Canada; Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada; Techna Institute, University Health Network, Toronto, ON, Canada.

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http://dx.doi.org/10.3389/fonc.2016.00221DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5073092PMC
October 2016

In Vivo Imaging Reveals Significant Tumor Vascular Dysfunction and Increased Tumor Hypoxia-Inducible Factor-1α Expression Induced by High Single-Dose Irradiation in a Pancreatic Tumor Model.

Int J Radiat Oncol Biol Phys 2017 01 14;97(1):184-194. Epub 2016 Sep 14.

Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada; Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada; Techna Institute, University Health Network, Toronto, Ontario, Canada. Electronic address:

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https://linkinghub.elsevier.com/retrieve/pii/S03603016163317
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http://dx.doi.org/10.1016/j.ijrobp.2016.09.005DOI Listing
January 2017

Hybrid Manganese Dioxide Nanoparticles Potentiate Radiation Therapy by Modulating Tumor Hypoxia.

Cancer Res 2016 11 6;76(22):6643-6656. Epub 2016 Oct 6.

Advanced Pharmaceutics and Drug Delivery Laboratory, Leslie Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1158/0008-5472.CAN-15-3475DOI Listing
November 2016

Can Imaging Put the "" Back in Advanced Wound Care?

Adv Wound Care (New Rochelle) 2016 Aug;5(8):329-331

U.S. Army Institute of Surgical Research , Fort Sam Houston, Texas.

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http://dx.doi.org/10.1089/wound.2016.0702DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4991594PMC
August 2016

Optically-tracked handheld fluorescence imaging platform for monitoring skin response in the management of soft tissue sarcoma.

J Biomed Opt 2015 Jul;20(7):076011

University Health Network, Princess Margaret Cancer Centre, Toronto Medical Discovery Tower, MaRS Centre, 101 College Street, Toronto, Ontario M5G 1L7, CanadacUniversity Health Network, Techna Institute, 124-100 College Street, Toronto, Ontario M5G 1P5, C.

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http://dx.doi.org/10.1117/1.JBO.20.7.076011DOI Listing
July 2015

Handheld fluorescence imaging device detects subclinical wound infection in an asymptomatic patient with chronic diabetic foot ulcer: a case report.

Int Wound J 2016 Aug 22;13(4):449-53. Epub 2015 Apr 22.

Princess Margaret Cancer Centre and Techna Institute, University Health Network, Toronto, Canada.

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http://dx.doi.org/10.1111/iwj.12451DOI Listing
August 2016

Autofluorescence imaging device for real-time detection and tracking of pathogenic bacteria in a mouse skin wound model: preclinical feasibility studies.

J Biomed Opt 2014 Aug;19(8):085002

University Health Network, Princess Margaret Cancer Centre, 610 University Avenue, Toronto, Ontario M5G 2M9, CanadabUniversity of Toronto, Department of Medical Biophysics, Faculty of Medicine, 1 King's College Circle, Toronto, Ontario M5S 1A8, CanadaeUni.

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http://dx.doi.org/10.1117/1.JBO.19.8.085002DOI Listing
August 2014

Multifunctional albumin-MnO₂ nanoparticles modulate solid tumor microenvironment by attenuating hypoxia, acidosis, vascular endothelial growth factor and enhance radiation response.

ACS Nano 2014 Apr 4;8(4):3202-12. Epub 2014 Apr 4.

Department of Pharmaceutical Sciences, Leslie L. Dan Faculty of Pharmacy, University of Toronto , Toronto, Ontario M5S 3M2, Canada.

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http://dx.doi.org/10.1021/nn405773rDOI Listing
April 2014

Optimization of the dorsal skinfold window chamber model and multi-parametric characterization of tumor-associated vasculature.

Intravital 2014 4;3(1):e27935. Epub 2014 Feb 4.

Ontario Cancer Institute; University Health Network; Toronto, ON Canada; Department of Medical Biophysics; University of Toronto; Toronto, ON Canada.

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http://dx.doi.org/10.4161/intv.27935DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5312716PMC
February 2014

Tumor vascularization is critical for oncolytic vaccinia virus treatment of peritoneal carcinomatosis.

Int J Cancer 2014 Feb 29;134(3):717-30. Epub 2013 Aug 29.

Division of Experimental Therapeutics, Toronto General Research Institute, University Health Network, Toronto, Ontario, Canada; Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1002/ijc.28395DOI Listing
February 2014

Texture analysis of optical coherence tomography speckle for characterizing biological tissues in vivo.

Opt Lett 2013 Apr;38(8):1280-2

Department of Medical Biophysics, University of Toronto, 610 University Ave., Toronto, Ontario M5G 2M9, Canada.

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http://dx.doi.org/10.1364/OL.38.001280DOI Listing
April 2013

A novel solid lipid nanoparticle formulation for active targeting to tumor α(v) β(3) integrin receptors reveals cyclic RGD as a double-edged sword.

Adv Healthc Mater 2012 Sep 25;1(5):600-8. Epub 2012 Jul 25.

Department of Pharmaceutical Sciences, Leslie L. Dan Faculty of Pharmacy, University of Toronto, Toronto, Ontario, Canada, M5S 3M2.

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http://dx.doi.org/10.1002/adhm.201200006DOI Listing
September 2012

Displaying 3D radiation dose on endoscopic video for therapeutic assessment and surgical guidance.

Phys Med Biol 2012 Oct 25;57(20):6601-14. Epub 2012 Sep 25.

Radiation Medicine Program, Princess Margaret Hospital, 610 University Ave, Toronto, ON M5G 2M9, Canada.

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http://dx.doi.org/10.1088/0031-9155/57/20/6601DOI Listing
October 2012

Quantifying tissue microvasculature with speckle variance optical coherence tomography.

Opt Lett 2012 Aug;37(15):3180-2

Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada.

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http://dx.doi.org/10.1364/OL.37.003180DOI Listing
August 2012

Estimation of minimum doses for optimized quantum dot contrast-enhanced vascular imaging in vivo.

Small 2012 Jun 19;8(11):1780-92. Epub 2012 Mar 19.

Department of Medical Biophysics, University of Toronto, 610 University Ave., Toronto, Ontario, Canada.

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http://dx.doi.org/10.1002/smll.201102105DOI Listing
June 2012

Aberrant axial mineralization precedes spinal ankylosis: a molecular imaging study in ank/ank mice.

Arthritis Res Ther 2011 12;13(5):R163. Epub 2011 Oct 12.

Institute of Medical Science, University of Toronto, 1 King’s College Circle, Toronto, Ontario, M5S 1A8, Canada.

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http://dx.doi.org/10.1186/ar3482DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3308096PMC
December 2012

Porphyrin-cross-linked hydrogel for fluorescence-guided monitoring and surgical resection.

Biomacromolecules 2011 Sep 26;12(9):3115-8. Epub 2011 Jul 26.

Institute of Biomaterials and Biomedical Engineering, University of Toronto, ON, M5G 1L7, Canada.

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http://pubs.acs.org/doi/abs/10.1021/bm200784s
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http://dx.doi.org/10.1021/bm200784sDOI Listing
September 2011

Fluorescence and spectral imaging.

ScientificWorldJournal 2007 Dec 21;7:2046-71. Epub 2007 Dec 21.

Department of Medical Biophysics, University of Toronto, Ontario Cancer Institute, 610 University Avenue, Toronto, Ontario, M5G 2M9, Canada.

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http://www.hindawi.com/journals/tswj/2007/730592/abs/
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http://dx.doi.org/10.1100/tsw.2007.308DOI Listing
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5901286PMC
December 2007

High throughput quantification of protein expression of cancer antigens in tissue microarray using quantum dot nanocrystals.

Nano Lett 2006 Dec;6(12):2881-6

Division of Applied Molecular Oncology, Ontario Cancer Institute, Toronto, Ontario M5G 2M9, Canada.

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http://pubs.acs.org/doi/abs/10.1021/nl062111n
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http://dx.doi.org/10.1021/nl062111nDOI Listing
December 2006

Spectroscopy and fluorescence in esophageal diseases.

Best Pract Res Clin Gastroenterol 2006 Feb;20(1):41-57

Department of Medical Biophysics, University of Toronto, Ontario Cancer Institute/University Health Network, Toronto, Ont., Canada.

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http://dx.doi.org/10.1016/j.bpg.2005.08.003DOI Listing
February 2006

Optical techniques for the endoscopic detection of dysplastic colonic lesions.

Curr Opin Gastroenterol 2005 Jan;21(1):70-9

Department of Medical Biophysics, University of Toronto, Ontario Cancer Institute/University Health Network, Toronto, Ontario, Canada.

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January 2005

The potential of autofluorescence for the detection of single living cells for label-free cell sorting in microfluidic systems.

Electrophoresis 2004 Nov;25(21-22):3740-5

Mesa+ Institute, Lab-on-a-Chip group, University of Twente, Enschede, The Netherlands.

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http://dx.doi.org/10.1002/elps.200406070DOI Listing
November 2004

Autofluorescence-based detection of early neoplasia in patients with Barrett's esophagus.

Dig Dis 2004 ;22(2):134-41

Department of Gastroenterology and Hepatology, Academic Medical Center, Amsterdam, The Netherlands.

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http://dx.doi.org/10.1159/000080312DOI Listing
December 2004

Molecular fluorescence excitation-emission matrices relevant to tissue spectroscopy.

Photochem Photobiol 2003 Oct;78(4):384-92

Department of Medical Biophysics, University of Toronto, Toronto, Canada.

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http://dx.doi.org/10.1562/0031-8655(2003)078<0384:mfemrt>2.0.co;2DOI Listing
October 2003

New optical technologies for earlier endoscopic diagnosis of premalignant gastrointestinal lesions.

J Gastroenterol Hepatol 2002 Feb;17 Suppl:S85-104

Department of Medical Biophysics, University of Toronto, Ontario Cancer Institute/University Health Network, Canada.

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http://dx.doi.org/10.1046/j.1440-1746.17.s1.8.xDOI Listing
February 2002